Body Piercing Condit (e.g., Needle, Etc.) Patents (Class 604/272)
  • Patent number: 11896840
    Abstract: Provided are conformable light delivery devices for increasing light penetration depth and related methods. The device comprises a tissue penetrating member having a distal end and a proximal end, the tissue penetrating member configured to penetrate the tissue of the patient to be inserted into the tissue, wherein the tissue penetrating member is at least partially optically transparent along a surface of the tissue penetrating member positioned between the distal end of the tissue penetrating member and the proximal end of the tissue penetrating member to provide optical transmission of at least a portion of the light through the surface of the tissue penetrating member, thereby allowing at least the portion of the light to be delivered into the tissue of the patient when the tissue penetrating member is inserted into the tissue; and a substrate that supports the tissue penetrating member.
    Type: Grant
    Filed: November 30, 2022
    Date of Patent: February 13, 2024
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Shuai Xu, Chenkai Xu, Hao Zhang, Hangbo Zhao, John A. Rogers
  • Patent number: 11819573
    Abstract: In some embodiments provided herein is a method of treating hip pain in a subject, the method comprising administering into the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.
    Type: Grant
    Filed: March 2, 2022
    Date of Patent: November 21, 2023
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Jonathan H. Slonin, Roy Winston, Stan Dysart
  • Patent number: 11813357
    Abstract: In some embodiments provided herein is a method of treating hip pain in a subject, the method comprising administering into the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: November 14, 2023
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Jonathan H. Slonin, Roy Winston, Stan Dysart
  • Patent number: 11793799
    Abstract: Provided is an anesthetic composition for locally administrating an amide-type anesthetic into a subject in need thereof. The anesthetic composition has multilamellar vesicles with entrapped amide-type anesthetic prepared by hydrating a highly entrapped lipid structure comprising an amide-type anesthetic and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more feasible process for large-scale manufacture and for providing a high molar ratio of amide-type anesthetic to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: October 24, 2023
    Assignees: TLC Biopharmaceuticals Inc., Taiwan Liposome Co., Ltd.
    Inventors: Keelung Hong, Hao-Wen Kao, Yi-Yu Lin, Luke S. S. Guo
  • Patent number: 11793934
    Abstract: Disclosed is a medical system having a cartridge and an inserter. The cartridge includes a housing having an interior volume with a first guide within the interior volume. A cradle is disposed within the interior volume and is configured for mounting a medical appliance. The cradle includes a subcutaneous element and an insertion needle. The insertion needle is configured for being actuated to insert the subcutaneous element into a subject. The inserter includes a second guide configured to mate with the housing of the cartridge, and the first guide and second guide are configured to cooperate to guide the inserter into the interior volume along a guiding path defined by the first guide. The inserter is configured to removably attach to the cradle when guided into the interior volume. An insertion assembly is provided for actuating the insertion needle to insert the subcutaneous element into the subject.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: October 24, 2023
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Frank Deck
  • Patent number: 11717618
    Abstract: Medicinal fluid delivery devices and methods for advancing and retracting needles are disclosed. According to an aspect, a medicinal fluid delivery device includes a tube that defines an interior space that extends between a first and second openings. The device includes a needle including a proximal end and a distal end that substantially align in a first direction. A portion of the distal end is biased to extend in a second direction different than the first direction. A mechanism is attached to the proximal end and configured to position the distal end between a first position and a second position. In the first position, the portion of the distal end is constrained by the interior wall such that is does not extend in the second direction. In the second position, the distal end is not constrained by the interior wall such that it extends in the second direction.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: August 8, 2023
    Assignee: Duke University
    Inventors: Kathleen Carroll, Ru-Rong Ji, Linda Gray-Leithe, Timothy Amrhein, Shivanand Lad
  • Patent number: 11701254
    Abstract: Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes an injector cannula having a soft injector tip. A retractable tip protector tube is slidably disposed on the flow cannula between an extended position in which the tip protector tube covers the entire injector tip, and a retracted position in which the tip protector tube is retracted proximally thereby exposing at least part of the injector tip. Accordingly, the tip protector tube protects the injector tip from being damaged while advancing the injector tip to a target injection site.
    Type: Grant
    Filed: November 21, 2020
    Date of Patent: July 18, 2023
    Assignee: ALTAVIZ, LLC
    Inventors: Jack R. Auld, Matthew Flowers, Tammo Heeren, Hien Nguyen, John C. Huculak, Eric Anderfaas
  • Patent number: 11690974
    Abstract: A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: July 4, 2023
    Assignee: WARSAW ORTHOPEDIC, INC.
    Inventors: Benjamin T. Reves, Todd M. Boyce, Daniel A. Shimko, Jared T. Wilsey
  • Patent number: 11642241
    Abstract: Embodiments include a cryogenic device for alleviating pain by cryogenically treating a nerve, the cryogenic device including a handpiece; a needle coupled to a distal end of the handpiece, the needle including a needle lumen, the needle being configured for insertion into a skin of a patient along an insertion axis at a site laterally displaced from a treatment zone proximate to the nerve. The needle is configured to resiliently bend after insertion away from the insertion axis, such that at least a portion of the needle is adapted to traverse a skin layer laterally toward the treatment zone. The device includes a cooling fluid supply tube extending distally into the needle lumen; and a cooling fluid source, wherein the cooling fluid source is coupled to the cooling fluid supply tube to direct cooling fluid into the needle lumen.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: May 9, 2023
    Assignee: Pacira CryoTech, Inc.
    Inventors: Jwala Karnik, Jason Reynolds, John Allison, Clint Carnell
  • Patent number: 11617519
    Abstract: A device includes a syringe, which has a tip, plunger, and barrel containing a fluid. The device also includes a needle electrode coupled to the tip of the syringe, a release component, and a control component configured to receive electrical measurements made by the needle electrode, determine impedance values from the electrical measurements, and identify a target tissue based on the impedance values. In response to the identification, the control component generates instructions to reposition a release component. A method includes receiving electrical measurements from a needle electrode, determining impedance values based on the electrical measurements. A target tissue is identified based on the impedance values, and a release component is repositioned in response.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: April 4, 2023
    Assignee: International Business Machines Corporation
    Inventors: Sarah K. Czaplewski-Campbell, Eric J. Campbell, Jennifer I. Bennett, Elin F. LaBreck, Christopher Steffen
  • Patent number: 11590294
    Abstract: A syringe assembly for a drug delivery device. The syringe assembly includes a syringe barrel having a proximal end, a distal end, and a longitudinal axis. A needle assembly is operatively coupled to the syringe barrel and includes a needle hub and a needle attached to the needle hub. A flexible connection is disposed between the syringe barrel and the needle hub and forms a fluid pathway between the syringe barrel and the needle. The flexible connection enables the needle assembly to be moveable from a filling position, in which a longitudinal axis of the needle assembly is parallel to a longitudinal axis of the syringe barrel, to an assembled position, in which the longitudinal axis of the needle assembly is not parallel to the longitudinal axis of the syringe barrel.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: February 28, 2023
    Assignee: AMGEN INC.
    Inventors: Adam B. McCullough, Hans Stenberg Knudsen, Rasmus Øhlenschlæger
  • Patent number: 11534204
    Abstract: A puncture apparatus includes: a needle member having a tubular shape and comprising a flexible portion that is deformable; and a puncture assisting member that is movable or deformable in an axial direction of the needle member between: a restricting position in which the puncture assisting member is located outside the flexible portion of the needle member in a radial direction of the needle member, and thereby restricts deformation of the flexible portion, and a permissive position in which the puncture assisting member is not located outside the flexible portion in the radial direction, and thereby permits deformation of the flexible portion. The puncture assisting member is configured to move or deform from the restricting position to the permissive position in conjunction with an operation of inserting the flexible portion into a living body at a time of puncturing the living body with the needle member.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: December 27, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Shuhei Sasazawa, Takeshi Akiyama
  • Patent number: 11517729
    Abstract: Systems and methods are provided for fabricating microneedle arrays that includes electrospun fibers preferentially disposed within the microneedles of the array. Providing the electrospun fibers preferentially in the microneedles allows for more of a drug or other substance present in the fibers to be deposited into tissue or to provide other benefits. A mold for forming the microneedle arrays includes an insulating surface layer. The insulating surface layer affects the electric field during electrospinning such that electrospun fibers are deposited preferentially within the microneedle cavities of the mold relative to the surface of the mold. A bulk material can then be applied to the mold to form the bulk of the microneedles with electrospun fibers embedded within and a backing layer to which the microneedles are attached.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: December 6, 2022
    Assignee: University of Washington
    Inventors: Rachel Creighton, Kim Woodrow
  • Patent number: 11517239
    Abstract: The present specification describes systems and methods that enable the automatic detection, analysis and calculation of various processes and parameters associated with electromyography. The methods of the present specification include the automated modulation of analytical or recording states based on the nature of the signal, optimal reference fiber selection, modulating a trigger level, and determining firing parameters.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: December 6, 2022
    Assignee: Cadwell Laboratories, Inc.
    Inventors: Michal Holub, David Jensen, Craig Cooper
  • Patent number: 11452853
    Abstract: A microneedle chip and manufacturing method. The method comprises injecting, into a female mold, a fluid needle liquid, wherein forming cavities matching the shapes of needles of a microneedle chip are provided at the female mold and form a cavity array, injection inlets are provided at a surface of one side of the female mold, and air ejection openings are provided at a surface of another side of the female mold to form an air ejection surface; covering the air ejection surface of the female mold using a breathable film, and during injection, passing a gas through the breathable film so as to retain the liquid inside the forming cavities; curing the fluid needle liquid to form the microneedle chip, and demolding to obtain the same. By employing the air ejection openings and the breathable film, a liquid is retained while ejecting a gas, providing a favorable micro-injection effect.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: September 27, 2022
    Assignees: GUANGZHOU MICNANO BIOTECH CO., LTD, GUANGZHOU NOVAKEN PHARMACEUTICAL CO., LTD.
    Inventors: Ge Li, Hangping Chen, Minmin Zhang, Qian Zhang, Gangtao Yao
  • Patent number: 11439745
    Abstract: A drug delivery device includes a blunt cannula and a reservoir. The blunt cannula has a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula. The wall has at least a first tapered region at the first end to define an opening in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula. The reservoir is connected to the second end of the blunt cannula.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: September 13, 2022
    Assignee: AMGEN INC.
    Inventors: Lawrence Ring, Dhairya Mehta, Stephanie Toy, Ferry Tamtoro, Alexander Stuart Cairns, Scott R. Gibson
  • Patent number: 11419632
    Abstract: Systems, devices, and methods are provided for transseptal access of septa within a patient. The device can be advanced to a septum, e.g., towards a fossa ovalis. Instead of applying positive pressure to “tent” the septum, a negative pressure is applied to a lumen within a sheath, e.g., within an elongated member slidable within the sheath, via a negative pressure source such as a syringe on the proximal end of the sheath. This results in the septum pulling inward. The sheath employs a stationary needle-like central core component contained within the lumen of the sheath that punctures the septum when the same is pulled passed it by the negative pressure. The stationary needle-like central core component may be hollow and may form a portion of the elongated member or may be coupled to a distal end thereof.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: August 23, 2022
    Assignee: Mark D. Wieczorek, P.C.
    Inventor: Mark D. Wieczorek
  • Patent number: 11413312
    Abstract: The present invention provides a method of treating a subject suffering from dry eye syndrome, comprising: administering to said subject a pharmaceutical composition for treating dry eye syndrome, comprising an effective amount of adipose-derived mesenchymal stem cells and the pharmaceutical composition is administered to the eye topically in the form of eye drops.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: August 16, 2022
    Assignee: National Taiwan University
    Inventors: I-Hsuan Liu, Chung-Tien Lin
  • Patent number: 11351312
    Abstract: Disclosed is a medical system for displaying and recording injection sites of patients. After patient identification based on the patient's vein patterns, the system can retrieve and display previous injection sites (e.g., for blood draw or injection) of the patient as overlaid at actual positions of the injection sites. The system can determine potential new injection sites based on the locations of the previous injection sites. The system can also ensure workflow compliance by displaying and tracking procedures performed by the healthcare professional.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: June 7, 2022
    Assignee: Becton, Dickinson and Company
    Inventors: Yuri Haverman, Oliver Crespo Diaz, Alan Wayne Fiedler
  • Patent number: 11331277
    Abstract: Disclosed herein is a nanoparticle comprising a copolymer comprising a polyethylene glycol polymer, a polyhydroxylated polymer, and a peroxide-sensitive pendant group; a glucose-responsive agent; and a therapeutic agent; wherein the copolymer encapsulates the glucose-responsive agent and the therapeutic agent. Also disclosed herein is a method of delivering a therapeutic agent to a subject comprising administering to the subject a nanoparticle comprising a copolymer comprising a polyethylene glycol polymer, a polyhydroxylated polymer, and a peroxide-sensitive pendant group; a glucose-responsive agent; and a therapeutic agent; wherein the copolymer encapsulates the glucose-responsive agent and the therapeutic agent; and releasing the therapeutic agent from the nanoparticle in the presence of hyperglycemic levels of glucose.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: May 17, 2022
    Assignee: North Carolina State University
    Inventors: Zhen Gu, Xiuli Hu
  • Patent number: 11318292
    Abstract: The disclosure belongs to medical devices and particularly to soluble microneedle patches and small dose medical injection devices for transdermal injections of medical and cosmetic materials to patients. It also belongs to micro-electro-mechanical systems technology (MEMS). The materials can include vitamins, proteins, glycerides, vaccines, mono-, oligo- or polysaccharides, organic acids and its salts, as well as combinations of the said materials and their derivatives. The disclosed micro-needle patch can be used for medical purposes in hospitals, outpatient and home conditions.
    Type: Grant
    Filed: May 27, 2019
    Date of Patent: May 3, 2022
    Assignee: Microneedles Inc.
    Inventors: Vasilii Nikolaevich Zvezdin, Ivan Arkadevich Kasatkin, Tatiana Igorevna Akafeva
  • Patent number: 11304632
    Abstract: A blood glucose detection device includes a carrier body, a flow-guiding actuator, a microneedle patch, a sensor and a controlling chip. The carrier body has a liquid guiding channel, a compressing chamber and a liquid storage chamber. The flow-guiding actuator seals the compressing chamber. The microneedle patch is attached on the carrier body and has plural hollow microneedles. The sensor is disposed within the liquid storage chamber. The controlling chip is disposed on the carrier body. The plural hollow microneedles puncture the skin of a human subject with minimal invasion. The controlling chip controls the flow-guiding actuator to actuate and the tissue fluid is sucked into the liquid storage chamber through the plural hollow microneedles, whereby the sensor detects the blood glucose of the tissue fluid to generate and transmit the measured data to the controlling chip. The controlling chip can generate monitoring information by calculating the measured data.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: April 19, 2022
    Assignee: MICROJET TECHNOLOGY CO., LTD.
    Inventors: Hao-Jan Mou, Li-Pang Mo, Chi-Feng Huang, Yung-Lung Han, Wei-Ming Lee, Hsuan-Kai Chen
  • Patent number: 11291816
    Abstract: Provided herein are microneedle particles, compositions that include microneedle particles, methods of treating skin, and methods of delivering a substance of interest. The microneedle particles may include one or more microneedles, and the microneedle particles may be configured to prevent the entire microneedle particle from penetrating the biological tissue. The microneedle particles may be dispersed in a liquid medium to form a composition. A biological tissue may be contacted with the microneedle particles to pre-treat the biological tissue, and a substance of interest may be applied to the pre-treated biological tissue.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 5, 2022
    Assignee: Georgia Tech Research Corporation
    Inventors: Andrew Tadros, Mark R. Prausnitz
  • Patent number: 11291801
    Abstract: A patient access site securement system includes a housing with an inlet, an outlet and an internal fluid path between the inlet and the outlet. The housing also has a connecting portion that connects to a catheter and/or a fluid line attached to the catheter. A contact surface is located on an underside of the housing and positions the patient access site securement system on the patient. A first reservoir with an interior holds a liquid and transitions from a first state to a second state. The interior is in fluid communication with the inlet when the reservoir is in the second state to allow the liquid to flow from the inlet, through the internal fluid path and exit the outlet. The liquid interacts with the contact surface and/or the patient to alter a level of securement between the catheter and the patient.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: April 5, 2022
    Assignee: NP Medical Inc.
    Inventors: Todd M. Chelak, Andrew Galanis, Jonathan Gabel
  • Patent number: 11273291
    Abstract: A catheter assembly includes: a catheter having an inner cavity extending along a center axis of the catheter, the catheter comprising, on a distal side, a tapered portion that is tapered in a distal direction; and an inner needle retractably located in the inner cavity. The inner needle comprises, on a distal side, a blade surface that is inclined with respect to a center axis of the inner needle. The tapered portion covers a proximal end portion of the blade surface in an assembled state in which the inner needle is located in the inner cavity, and an inner shape of a distal-most end of the tapered portion conforms to the blade surface.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: March 15, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Takayuki Yokota
  • Patent number: 11260159
    Abstract: A percutaneous catheter provides an adjustable diameter in order to reduce pressure loss, maintain a required flow, and avoid increasing a load to the patient. A catheter tube is formed of braided wires in an intersecting manner and extends in an axial direction. A distal tip is affixed to a distal side of the catheter tube and is configured to engaged a distal end of a dilator. The catheter tube includes a non-coated portion on a proximal side of the distal tip and a coated portion embedded in a resin material. An inner diameter of the non-coated portion is larger than an outer diameter of the dilator. When the dilator is fully inserted through the percutaneous catheter, the non-coated portion expands in the axial direction, reducing its in inner diameter so that an inner surface of the non-coated portion comes into tight contact with an outer surface of the dilator.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: March 1, 2022
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Kenji Yokoyama
  • Patent number: 11253393
    Abstract: A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: February 22, 2022
    Assignee: Pacira CryoTech, Inc.
    Inventors: Jwala Karnik, John Allison, Clint Carnell
  • Patent number: 11207465
    Abstract: A method and assembly are disclosed for interfacing between a drug cartridge and a drug delivery device. Optionally, the drug delivery device includes a compartment that retains the cartridge during drug delivery and/or a stopper pushing assembly mounted to the device behind (proximal to) the compartment. In some embodiments, the cartridge may be inserted laterally into the compartment in front of the pushing assembly. For example, the delivery device may include a moving cartridge bay. The cartridge is optionally inserted into the bay and/or the bay and cartridge optionally move into the cartridge compartment. Alternatively or additionally, the cartridge compartment may have a proximal opening into which the cartridge is inserted and/or the pushing assembly may be moved into position after insertion of the cartridge. In some embodiments the cartridge may have a distal seal that is broken by a longitudinal movement.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: December 28, 2021
    Assignee: West Pharma. Services IL. Ltd.
    Inventors: Yossi Bar-El, gil Yigal, Reuven Y. Filman
  • Patent number: 11179553
    Abstract: A device for delivery of material to a biological subject, the device including a base and a number of projections extending from the base, each projection including a tip for penetrating tissue of the biological subject, at least a portion of at least one of the projections being coated with a non-liquid coating including the material. At least the tip of at least one of the coated projections may have a convex effective profile. The device may be for delivery of material to a dermal layer of the biological subject. In another aspect an applicator for applying the device to the biological subject applies a preload force to the tissue such that the force at least partially compresses a subcutaneous tissue layer of the biological subject prior to application of the device, and applies the device with a predetermined velocity, wherein tissue stiffness is maintained and/or the projections penetrate the tissue to a predetermined depth.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: November 23, 2021
    Assignee: VAXXAS PTY LIMITED
    Inventors: Mark Anthony Fernance Kendall, Stefano Meliga, Alexandra Christina Isabelle Depelsenaire, Michael Lawrence Crichton, Christopher Flaim
  • Patent number: 11172912
    Abstract: Disclosed is a biopsy needle, medical device incorporating the biopsy needle, and method of using the biopsy needle and medical device. The biopsy needle and medical device is used to obtain a sample of tissue for further analysis and testing. The biopsy needle includes an inner stylet that is slidably engaged with an outer coaxial sheath and at least part of the distal portion of the stylet is bent or curved relative to the longitudinal axis of the coaxial sheath.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: November 16, 2021
    Assignee: INNOVASCI LLC
    Inventor: Charles Rafic Wehbe
  • Patent number: 11065429
    Abstract: Provided is a method of producing a microneedle array unit which is capable of suppressing damage to a microneedle array.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: July 20, 2021
    Assignee: FUJIFILM Corporation
    Inventors: Yuka Kobayashi, Yasuhiro Sekizawa
  • Patent number: 11059194
    Abstract: A functional polymeric cutting edge structure and methods for manufacturing cutting edge structures using polymeric materials are provided. A razor blade for use in a razor cartridge or a blade box for assembly in a razor cartridge frame may be formed using the present invention.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: July 13, 2021
    Assignee: The Gillette Company LLC
    Inventors: Matthias Gester, Roman Kiyan, Ulf Hinze, Kestutis Kurselis
  • Patent number: 11020107
    Abstract: A suture capturing device configured to attain multiple preset orientations, comprising: a handle; a hollow shaft coupled to said handle; a rigid needle element configured with a hook for catching a suture and where the needle element is operatively coupled to the hollow shaft opposite the handle and configured to be slidable in a first direction to assume an open orientation where the hook is exposed relative to the hollow shaft and in a second direction to assume a closed orientation where the hook is not exposed relative to the hollow shaft.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: June 1, 2021
    Assignee: T.A.G. Medical Devices—Agriculture Cooperative Ltd.
    Inventors: Aryeh Mirochinik, Shai Nachmias, Roy Zilberman
  • Patent number: 10987503
    Abstract: A skin treatment can include applying a microneedle device to a region of the skin so that microneedles of the device penetrate the stratum corneum. The arrangement of microneedles can have first microneedles with a first length and second microneedles with a second length, different from the first length. The first and second microneedles can be formed from a mixture of a polymeric material and an active agent beneficial to skin. After the device is applied to the skin, the first and second microneedles can be released below the skin surface, followed by dissolution of the first and second microneedles.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: April 27, 2021
    Assignee: ALLERGAN, INC.
    Inventors: Justin J. Schwab, Michael Augarten, Zachary Dominguez, Ethan Franklin, Edwin J. Kayda, Jason Metzner
  • Patent number: 10953152
    Abstract: A piercing part for a medical infusion system includes a piercing mandrel through which at least one channel extends and which has a mandrel tip whose first jacket surface part is tapered, relative to a central longitudinal axis, towards a front end. An opposite second jacket surface part has an inclined cutting face interrupted towards the front end. The piercing part can be used for medical transfusion and infusion appliances.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: March 23, 2021
    Assignee: B. BRAUN MELSUNGEN AG
    Inventors: Christof Schlitt, Manfred Lutz
  • Patent number: 10952895
    Abstract: A phacoemulsification needle (100, 100A, 100B, 1000, 100D, 200, 200A) is provided for emulsifying body tissue. The needle (100, 100A, 100B, 1000, 100D, 200, 200A) is adapted to be attached to a phacoemulsification handpiece that imparts a vibration to the needle (100, 100A, 100B, 100C, 100D, 200, 200A). The needle (100, 100A, 100B, 1000, 100D, 200, 200A) has a body (104, 220, 220A) with a distal end (99), a proximal end (106), and an aspiration passage (124) extending between the proximal and distal ends (99, 106). The aspiration passage (124) defines a longitudinally-extending central body axis (110, 110A, 110B, 1100, 110D). The aspiration passage (124) is enlarged at the distal end (99) to define a tip (102, 102A, 102B, 1020, 102D, 210, 210A).
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: March 23, 2021
    Inventors: Takayuki Akahoshi, Ravi Nallakrishnan
  • Patent number: 10933173
    Abstract: A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include one or more microneedles mounted to a substrate. The silk fibroin can include active agents to be transported into or across biological barriers such as skin, tissue and cell membranes. The silk fibroin microneedles can be fully or partially biodegradable and/or bioerodible. The silk fibroin is highly stable, affords room temperature storage and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: March 2, 2021
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Konstantinos Tsioris, Fiorenzo G. Omenetto, Eleanor M. Pritchard
  • Patent number: 10925618
    Abstract: A rongeur including a base, which includes a handle portion, a body portion and a shaft portion. The shaft portion is made of a metal material and includes a male mold-on interlock portion configured to non-removably interlock with an over-molded plastic material. The body portion is made of plastic material and includes an over-mold interlock portion that is over-molded onto and non-removably fixed onto the mold-on interlock portion of the shaft portion. A slide shaft of the rongeur includes a distal portion and a proximal portion. The distal portion is made of a metal material and includes a male mold-on interlock portion configured to non-removably interlock with an over-molded plastic material. The proximal portion is made of a plastic material and includes an over-mold interlock portion that is over-molded onto and non-removably fixed onto the mold-on interlock portion of the distal portion.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: February 23, 2021
    Assignee: STERIBITE, LLC
    Inventors: John A. Redmond, Mark T. Whiteaker
  • Patent number: 10912542
    Abstract: Disclosed embodiments include catheter assemblies, systems for sampling a targeted region of tissue, and methods of sampling a targeted region of tissue. In an illustrative, non-limiting embodiment, a catheter assembly includes: a catheter defining a lumen therein, a wall of the catheter defining an opening therein at a distal end of the catheter; and a curved flexible needle disposable in the lumen and being extendable from the opening at the distal end of the catheter at an angle that diverges from an axis of the lumen.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: February 9, 2021
    Assignee: Spiration, Inc.
    Inventors: Madeline C. Graham, Matthew E. Nickeson
  • Patent number: 10835285
    Abstract: Devices, systems, and methods for delivering a substance within a mammalian luminal organ or area adjacent thereto. In at least one exemplary embodiment of a system of the present disclosure, the system comprises an inner delivery device, comprising an inner portion configured to receive a substance therein, a pock tip at or near a distal end of the inner delivery device, the pock tip configured to deliver the substance from the inner portion, through a pock tip aperture defined within the pock tip, and into a mammalian tissue and/or luminal organ, and an embolus positioned within the inner portion, the embolus configured so that the substance remains distal to the embolus when the substance is positioned within the inner portion.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: November 17, 2020
    Assignee: CVDevices, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr.
  • Patent number: 10773019
    Abstract: An infusion system comprises an infusion set (30) with one or more advanced features including tube set strain relief (10), infusion pumps having heat exchange abilities and two-direction pumping abilities (100), Piezo pump devices (200), reservoirs (220, 240) made from expanded tubing, and oil impregnated pump plungers (302). An exemplary strain relief (10) includes an adhesive layer (12) such as pressure sensitive adhesive (PSA) secured to a base (14). The base (14) rotatably receives a pin (18) of a tube holder (16). The pin (18) is captured within an opening (22) of the base (14) to allow 360 degree rotation of the tube holder (16).
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: September 15, 2020
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Gary M. Searle, Charles G. Hwang
  • Patent number: 10709846
    Abstract: User-friendly attachment mechanisms for pen needles provide improved handling and ease of use, including locking installation and removal features and sensory feedback when a needle-bearing hub is seated on a pen. Embodiments include a needle-bearing hub includes a circumferentially oriented flexible tab that engages a radially inward rib on an outer cover to assist in attaching a pen device to the pen needle.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: July 14, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: Sudarsan Srinivasan, Michael DiBiasi, Sean Sullivan, Keith Knapp, Joshua Herr, Amit Limaye, David Huang, David Schiff, Todd Sack
  • Patent number: 10709884
    Abstract: Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier. The devices include microneedles for penetrating the stratum corneum and also include structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The pattern of structures on the surface of the microneedles may include nano-sized structures.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: July 14, 2020
    Assignee: SORRENTO THERAPEUTICS, INC.
    Inventor: Russell Frederick Ross
  • Patent number: 10702637
    Abstract: The present invention relates to a guiding needle for a suction tube, which is for increasing accuracy and preventing medical accidents by enabling an operator to accurately recognize the bent direction of the needle and to stably hold the needle by means of a handle portion formed inside the rear end of the needle connected to a tube or by means of a separate fixing handle coupled to the inside of the rear end of the needle. In other words, the present invention relates to a needle having the rear end thereof coupled to one end of a tube connected to a drainage container for discharging body blood of a patient, wherein the needle has a coupling part formed inside the rear end thereof and comprises a fixing handle detachably coupled to the coupling part.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: July 7, 2020
    Assignees: INDUSTRIAL COOPERATION FOUNDATION CHONBUK NATIONAL UNIVERSITY, CHONBUK NATIONAL UNIVERSITY HOSPITAL, SUNGWON MEDICAL CO., LTD.
    Inventors: Jong Kwan Park, Jun Sung Park
  • Patent number: 10632290
    Abstract: A catheter assembly comprises a collar assembly comprising a coupling portion proximate the second end and a first compression member configured to removably engage the coupling portion. The catheter assembly further comprises a wing assembly that includes a housing configured to at least partially receive a cannula. The wing assembly also comprises two or more wings extending radially from the housing and a second compression member configured to removably engage a coupling portion. A tube is configured to fluidly couple the collar assembly to the wing assembly, and wherein a portion of the tube is retained by the first and second compression members.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: April 28, 2020
    Assignee: Tessy Plastics Corporation
    Inventors: David R. Young, Francis George Tatu, Willie Werner, Vincent Pilletteri, Stafford Frearson, Mark Lattimore
  • Patent number: 10624843
    Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic agent that is poorly soluble in water or an aqueous solvent.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: April 21, 2020
    Assignee: Corium, Inc.
    Inventors: Zhongli Ding, Guohua Chen, Parminder Singh
  • Patent number: 10603477
    Abstract: A skin treatment device is provided including bioerodible polymeric microneedles which are designed to more effectively deliver beneficial agents to the skin. The device includes a flexible substrate and an arrangement, for example, an array, of microneedles projecting from the substrate.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: March 31, 2020
    Assignee: Allergan, Inc.
    Inventors: Justin J. Schwab, Michael Augarten, Zachary Dominguez, Ethan Franklin, Edwin J. Kayda, Jason Metzner
  • Patent number: 10595833
    Abstract: The present invention relates to a surgical device. The surgical device may include: a needle device; an aspiration device, which is attached to or detached from the needle device, for tissue sampling; an injection device, which is attached to or detached from the needle device, for drug injection; and an electrode device, which is attached to or detached from the needle device, for thermal treatment. Therefore, any one of the aspiration device, the injection device, and the electrode device is attached to or detached from the needle device, thereby being capable of performing tissue sampling, drug injection, and thermal treatment. Thus, the time and costs required for tissue sampling, drug injection, and thermal treatment are reduced and foreign substances can be prevented from flowing into a surgical site in advance.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: March 24, 2020
    Assignee: STARMED CO., LTD.
    Inventors: Kyung Hoon Shin, Dong Un Kim, Hyuk Lim
  • Patent number: 10576257
    Abstract: An article comprising at least one microneedle is provided. The article can comprises a first side and a second side opposite the first side. The first side comprises a central cavity portion and a platform portion, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface; a base segment having a base and a first shape; a tip segment having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane that delineates the base segment and the tip segment; and a central axis. Methods of using the article are also provided.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: March 3, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Dennis G. Berry, Paul A. Martinson, Chin-Yee Ng, Ryan Patrick Simmers
  • Patent number: 10576188
    Abstract: A coating agent that has excellent durability and a medical instrument (for example, a needle) that has been coated with the coating agent, are provided. The coating agent includes a condensate (1) of a compound represented by the following general formula (1-1) with a compound represented by the following general formula (1-2), a polydiorganosiloxane (2), and an amino-group-containing polyorganosiloxane (3). The content ratio of the polydiorganosiloxane (2) is 30 to 75 mass %, based on the total mass of the condensate (1), the polydiorganosiloxane (2), and the amino-group-containing polyorganosiloxane (3).
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: March 3, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Teruyuki Yatabe