Soluble In Body (e.g., Suppository, Etc.) Patents (Class 604/288)
  • Patent number: 9462452
    Abstract: An exemplary technique is provided for an initial personalization of a smart card coupled with a communication device of a user. The smart card is configured to send a first request to a home location register that authenticates the user by means of a temporary international identity and a temporary authentication key. The smart card is configured to send a second request for smart card personalization to an application server. The smart card is configured to receive a response from the application server that contains a personalization command, an admin code, an initial international identity and an initial authentication key. The smart card is configured to interpret the personalization command to delete the temporary international identity and the temporary authentication key, and to replace them with the initial international identity and the initial authentication key when the admin code is valid.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: October 4, 2016
    Assignee: Alcatel Lucent
    Inventors: Yacine El Mghazli, Alberto Conte
  • Patent number: 9320878
    Abstract: This invention discloses a novel microneedle system, phase-transition microneedles (PTM), of which the microneedles formed of hydrophilic polymers are swelling but insoluble when absorbing water due to their internal cross-linked network through microcrystalline domains functioning as cross-linking junctions. The microneedles are sufficiently hard to penetrate the epidermis of the skin at dry state, but are converted to hydrogel state to release their loaded cargos by absorbing the body fluid in the dermis layer, and able to be withdrawn from the skin completely (without depositing needle tip materials in the skin) because of their insoluble network. Moreover, formation of the insoluble polymeric network through microcrystalline domains of PTM is achieved by a mild freeze-thaw treatment, for which bio-active agents may be loaded safely in the microneedle tips by adding in the polymer solution prior to molding without denaturing.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: April 26, 2016
    Inventor: Tuo Jin
  • Patent number: 8945038
    Abstract: A surgical technique and device wherein an indwelling tube is placed in the eye of a patient having glaucoma. The tube diverts aqueous humor from the anterior chamber to the suprachoroidal space from which it is removed by blood flowing in the choroidal and uveal tissues. This decreases the intraocular pressure.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: February 3, 2015
    Assignee: Transcend Medical, Inc.
    Inventor: Michael Yablonski
  • Publication number: 20140329902
    Abstract: A blood coagulating device can include an absorbent body; and a hemostatic lysine composition associated with the body. The body can have a cylindrical or conical member having a first end having the hemostatic composition, the first end being configured for insertion into a nasal passageway. A method for coagulating blood can include providing a powdered hemostatic lysine composition; and applying the powdered hemostatic lysine composition to blood so as to cause the blood to coagulate and form a clot. The coagulation can occur in a nasal passageway away from a blood vessel. The method can include providing at least one absorbent member having the powdered hemostatic lysine composition; and applying the at least one absorbent member to the blood so that the powdered hemostatic lysine composition causes the blood to coagulate and clot.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: Park City Bio, LLC
    Inventors: Jonathan M. Benns, Matthew C. Lawyer
  • Publication number: 20140296799
    Abstract: A degradable, removable, pharmaceutical implant for the sustained release of one or more drugs in a subject, wherein the pharmaceutical implant is composed of a tube comprising an outer wall made of a degradable polymer completely surrounding a cavity, wherein the outer wall has a plurality of openings and wherein the cavity contains one or more sets of micro-particles, which micro-particles contain an active agent or a combination of two or more active agents, and wherein the size of the microparticles is selected such that the majority of the microparticles cannot pass through the openings.
    Type: Application
    Filed: June 10, 2014
    Publication date: October 2, 2014
    Inventors: Lieven Elvire Colette Baert, Iksoo Chun, Guenter Kraus, Deborah M. Schachter, Qiang Zhang
  • Patent number: 8821456
    Abstract: A medication delivery system for delivering medication to an internal body cavity through a natural body orifice that opens to the cavity has a pad for external placement against the body orifice and an elongated body that extends from the pad through the body orifice when the pad is externally placed against the body orifice. The elongated body carries medication and is long enough to deliver the carried medication to tissue forming the body cavity. The pad has a medication-holding zone surrounding the elongated body on an inner face of the pad and carrying medication that is delivered externally to tissue surrounding the body orifice concurrent with delivery of the medication carried by the elongated body to the tissue forming the body cavity.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: September 2, 2014
    Inventor: Yousef Daneshvar
  • Publication number: 20140171882
    Abstract: An instrument for inserting a suppository which includes a tube, having a first end adapted to receive the suppository and a second end, and a plunger disposed in the tube and moveable therein to eject the suppository from the first end by causing an action of pushing the suppository from behind. Retaining tongues are splayed outwards for ejection of the suppository in response to movement of the plunger in the tube, via contacting cooperation between at least one part of the plunger and at least one part of the tube. Securement mechanism secure the plunger in the tube at first position in which the suppository is retained in the first end of the tube, while allowing a user to move the plunger to actuate the instrument, and to secure the plunger in the tube at a second position which is only achievable after the plunger has been moved to eject the suppository.
    Type: Application
    Filed: August 3, 2012
    Publication date: June 19, 2014
    Inventors: Gonzalo Hernández Herrero, Celestino Ronchi, Mauro Citterio, Lucas Sigman, Brett Mooney
  • Publication number: 20140074066
    Abstract: A rectally insertable device for localized drug delivery to the anal sphincter of a subject, a method of using the device and the use of the device is disclosed. The device comprises a shell for containing an active pharmaceutical ingredient, the shell being substantially impermeable to the active pharmaceutical ingredient wherein a lower portion of the shell is configured to release the active pharmaceutical ingredient from the shell and wherein when the device is inserted into the rectum of the subject, the lower portion of the shell is proximal to the anal sphincter, such that the active pharmaceutical ingredient is released proximal to the anal sphincter.
    Type: Application
    Filed: November 19, 2013
    Publication date: March 13, 2014
    Inventor: Nir Barak
  • Patent number: 8617139
    Abstract: Disclosed are devices, methods and systems for treatment of eye disease such as glaucoma. Implants are described herein that enhance aqueous flow through the normal outflow system of the eye with minimal to no complications. The implant can be reversibly deformed to a first shape, such as a generally linear shape conducive to insertion. Upon insertion, the implant can deform to a second shape, such as a generally non-linear shape conducive to retention within the eye. The shape also improves fluid flow from the anterior chamber and prevents or reduces clogging.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: December 31, 2013
    Assignee: Transcend Medical, Inc.
    Inventors: Thomas A. Silvestrini, Steven John, Jose Garcia, Richard S. Lilly
  • Patent number: 8568374
    Abstract: An intrauterine system is disclosed for use in the treatment of dysfunctional uterine bleeding; menorraghia; dysmenorrhoea; endometriosis; uterine fibroids; climacteric complaints; osteoporosis; and urogenital atrophy. The system is formed by a frame defining an interior space for receipt of a deposit of a therapeutically effective dose of a biologically active compound. The frame has an open structure allowing access to a substantial part of an outer surface of the deposit, and the deposit has a rate controlling structure that controls a rate of release of the compound within the uterus. One or more retention elements are provided on the frame for retaining the frame within the uterus of a female mammal.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: October 29, 2013
    Assignee: Merck Sharp & Dohme B.V.
    Inventors: Wouter De Graaff, Harm Veenstra, Titia Martine Truce Mulders
  • Publication number: 20130158395
    Abstract: A medical instrument for treating and/or diagnosing anorectal disorders which comprises a slender member that is sized and shaped for being placed in the anal canal of a patient, along at least a portion of the anal sphincter, so that an outer surface of the slender member is in contact with inner walls of the anal canal.
    Type: Application
    Filed: August 25, 2011
    Publication date: June 20, 2013
    Applicant: Ocure Ltd. High-Tech Village Givat Ram Campus
    Inventors: David Braver, Iris Shahar
  • Patent number: 8444588
    Abstract: A surgical technique and device wherein an indwelling tube is placed in the eye of a patient having glaucoma. The tube diverts aqueous humor from the anterior chamber to the suprachoroidal space from which it is removed by blood flowing in the choroidal and uveal tissues. This decreases the intraocular pressure.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: May 21, 2013
    Assignee: Transcend Medical, Inc.
    Inventor: Michael Yablonski
  • Patent number: 8217219
    Abstract: A vaginal insert formed from a composition that, prior to introduction to the vagina, has the physical properties of a liquid, semi-soft gel, paste, foam, or viscous material so that it can be effectively delivered to the vaginal canal. After introduction into the vagina, the composition will expand and/or solidify into a semi-solid or solid structure to substantially fill the entire “H” shaped space of the vagina and a portion of the rugal folds along the length of the vaginal canal. Upon solidifying, the composition defines an insert that, in one embodiment, is suitable for use as a tampon and, in another embodiment, is suitable for use as an incontinence device.
    Type: Grant
    Filed: December 29, 2003
    Date of Patent: July 10, 2012
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Kristin M. Shepard, MaryAnn Zunker
  • Patent number: 8206333
    Abstract: The present invention relates to an ocular implant, particularly a glaucoma stent. It is the object of the present invention to devise an ocular implant which allows the ocular eye pressure to be regulated, i.e., to be maintained at a desired level, while preventing the flow resistance from increasing over time, for example due to fibrosis. In order to achieve this object, the ocular implant according to the invention comprises a small tube (5), the wall surface (3) of which encloses a hollow duct that is open on both sides in the longitudinal direction of the hollow duct, wherein a first opening (1) allowing ocular humor to flow in and a second opening (2) allowing the ocular humor to be discharged is provided, and wherein the wall surface (3) is formed by a liquid-tight material, and wherein at least one pressure-controlled valve (4) is disposed in the area of the wall surface (3).
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: June 26, 2012
    Assignee: Universitaet Rostock
    Inventors: Wolfram Schmidt, Katrin Sternberg, Detlef Behrend, Rudolf Guthoff, Klaus-Peter Schmitz
  • Publication number: 20120150105
    Abstract: A uterine fibroid treatment device providing for localized delivery of one or more treatment drugs for treating various uterine conditions including, for example, uterine fibroids, abnormal uterine bleeding, pelvic adhesions and endometriosis. Generally, the uterine treatment device comprises a physical positioning element that can be inserted, positioned and maintained in close proximity to the uterine tissue to be treated. The treatment drugs delivered to the treatment location can include various combinations of anti-proliferative agents and angiogenesis inhibitors to provide different treatments concurrently. In some embodiments, the physical element can also serve the dual purpose of delivering the treatment drugs while simultaneously cutting off blood flow to a mature fibroid to initiate hypoxic/ischemic conditions within the mature fibroid.
    Type: Application
    Filed: August 16, 2010
    Publication date: June 14, 2012
    Inventors: Rosa K. Canifax, Thomas Q. Dihn, Edouard A. Koullick, Mark S. Bouchier
  • Patent number: 8196745
    Abstract: A suppository delivery device that allows for the insertion of a suppository without having contact with the suppository or rectum. The suppository delivery device includes a stabilizing platform, a stabilizer to which the suppository is mounted, and a package, which protects the user's hands and fingers from the suppository and rectum and prevents germs from contacting the suppository before being inserted into the rectum.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: June 12, 2012
    Assignee: Just Like Sisters, LLC
    Inventors: Karen D. Higgins, Kathleen K. Pieper
  • Patent number: 8167852
    Abstract: Microneedle device is provided, which include microneedles that can be easily inserted into skin and dissolve or swell in skin. The microneedle devices comprise a substrate and cone-shaped or pyramid-shaped microneedles for skin insertion set on the substrate. The microneedles for skin insertion contain over 50 weight percent of one or multiple biomaterials chosen from chitosan, collagen, gelatin, hyaluronic acid, and they are fabricated from the materials that can dissolve or swell in the body.
    Type: Grant
    Filed: April 1, 2008
    Date of Patent: May 1, 2012
    Assignee: Cosmed Pharmaceutical Co., Ltd.
    Inventors: Ying-shu Quan, Fumio Kamiyama, Yoshikazu Tobinaga, Tomoya Kitagawa, Kentaro Ohshima, Akira Yamamoto
  • Patent number: 8152793
    Abstract: The membrane shell of an implantable dosage system according to the invention is particularly suitable for subcutaneous applications to release an active agent with steady amounts during a longer period of time. The membrane shell (3) according to the invention comprises a first half (1) and a second half (2), which both halves comprise a continuous closure edge (8, 9), and are adapted to be connected to each other through a closable joint. The closure edges (8, 9) of the halves comprise at least one groove (10) and/or at least one protrusion (11) as continuous or discontinuous, and the membrane shell (3) is adapted to be closed so that at least one protrusion (11) and/or at least one groove (10) of the second half becomes opposed to at least one groove (10) and/or at least one protrusion (11) of the first half through a snap-fit joint.
    Type: Grant
    Filed: April 23, 2008
    Date of Patent: April 10, 2012
    Assignee: Bayer Oy
    Inventors: Antti Keinänen, Jukka Koskinen, Pentti Järvelä
  • Patent number: 8052650
    Abstract: A feeding device configured for insertion into the gastrointestinal tract of a patient, and dynamic movement through the gastrointestinal tract toward the jejunum. The device includes an elongate tubular member having a plurality of distal projections disposed on an exterior surface thereof. The projections extend radially outwardly from the exterior surface of the tubular member a distance sufficient to engage an interior surface of the gastrointestinal tract during peristaltic contractions therein, and are configured to promote ingress of the device in response to the contractions. At least some of the projections are soluble under bodily conditions at the gastrointestinal tract, thereby facilitating removal of the feeding device.
    Type: Grant
    Filed: April 15, 2008
    Date of Patent: November 8, 2011
    Assignee: Cook Medical Technologies LLC
    Inventors: Ronan T. Young, Mark J. Hiatt, Andrew K. Hoffa
  • Patent number: 7892216
    Abstract: An infusion set comprises a base member (60), an introducer cap (64), and an infusion cap (54). The base member (60) preferably comprises a soft cannula (52) extending from a lower side (118) of the base member (60), and a port (62) on an upper side (92) thereof. The port (62) is configured to be in fluid communication with the cannula (52). The port (62) also comprises a septum (130) adapted to seal the port (62) against unwanted fluid flow. The introducer cap (64) is adapted to be mounted to the base member (60) and has a needle (66) adapted to extend through the septum (130) and said soft cannula (52) in an assembled position. The infusion cap (54) comprises a lumen (160) adapted to receive an elongate flexible tube (162). The infusion cap (54) also comprises a hard cannula (170) adapted to be inserted through the septum (130) and to place said soft cannula (52) in fluid communication with said lumen (160).
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: February 22, 2011
    Assignee: ICU Medical, Inc.
    Inventor: Thomas F. Fangrow, Jr.
  • Publication number: 20100316740
    Abstract: Compositions including Serenoa repens, Echinacea and Hypericum perforatum extracts and selenium compounds for the treatment of prostate disorders, in particular for the treatment of prostate cancer, prostatitis, prostatosis and urinary incontinence.
    Type: Application
    Filed: February 17, 2009
    Publication date: December 16, 2010
    Applicant: INDENA S.P.A.
    Inventor: Ezio Bombardelli
  • Publication number: 20100280464
    Abstract: An intrauterine system is disclosed for use in the treatment of dysfunctional uterine bleeding; menorraghia; dysmenorrhoea; endometriosis; uterine fibroids; climacteric complaints; osteoporosis; and urogenital atrophy. The system is formed by a frame defining an interior space for receipt of a deposit of a therapeutically effective dose of a biologically active compound. The frame has an open structure allowing access to a substantial part of an outer surface of the deposit, and the deposit has a rate controlling structure that controls a rate of release of the compound within the uterus. One or more retention elements are provided on the frame for retaining the frame within the uterus of a female mammal.
    Type: Application
    Filed: April 29, 2010
    Publication date: November 4, 2010
    Inventors: Wouter De Graaff, Harm Veenstra, Titia Martine Truce Mulders
  • Patent number: 7824383
    Abstract: A vaginal drug delivery system includes a device formed of porous material that holds a flowable therapeutic formulation. The device, preferably in a soft, prewetted state, is inserted into the vagina to reside typically at or near the cervix where it continuously releases the flowable therapeutic formulation through its outer surface which is in contact with the vaginal surfaces. In operation, the flowable therapeutic formulation migrates via capillary forces from a reservoir that is centrally located in the device and through a covering that envelopes the reservoir.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: November 2, 2010
    Assignee: Family Health International
    Inventors: David C. Sokal, Carol L. Joanis, George A. M. Butterworth, James D. Reed, Robert A. Johnson
  • Publication number: 20100210600
    Abstract: Glycerophosphate salts have been found to drastically improve the treatment of urogenital disorders such as urethral strictures and vaginal atrophy. Methods, devices and kits are described for treating urogenital disorders using a composition comprising an effective amount of a glycerophosphate salt.
    Type: Application
    Filed: February 18, 2010
    Publication date: August 19, 2010
    Applicant: PRELIEF INC.
    Inventors: Alan E. KLIGERMAN, Joseph V. DITROLIO
  • Publication number: 20100168563
    Abstract: A device for application to a body cavity. The device is insertable into the cavity of a subject in need. The device includes a non-absorbable, flexible tube of an elongated shape, a removable core element situation within the tube, and a retention mechanism for maintaining the device within the cavity.
    Type: Application
    Filed: February 15, 2007
    Publication date: July 1, 2010
    Inventor: David Braver
  • Publication number: 20090227930
    Abstract: A topical product including but not limited to a feminine hygiene product or incontinence shield which contains at least two kinds of particulate metals distributed throughout which, when in contact with moisture, form a galvanic current (virtually if not completely imperceptible to the user) that has antimicrobial effect on all pathogens. Galvanic current virtually or completely imperceptible to the user facilitates antimicrobial effect.
    Type: Application
    Filed: February 23, 2009
    Publication date: September 10, 2009
    Inventor: William E. Crisp
  • Publication number: 20090124955
    Abstract: An ophthalmological device comprises an implant member carrying an antifibrotic agent that is released slowly over a prolonged period when inserted into a wound in an eye produced by surgery. The member is placed in the vicinity of a wound created during the surgery to inhibit inflammatory cell proliferation, thereby preventing the growth of fibrous tissue after the eye surgery.
    Type: Application
    Filed: November 24, 2008
    Publication date: May 14, 2009
    Inventor: Ramesh S. Ayyala
  • Publication number: 20090118702
    Abstract: Featured are devices for delivering a treatment medium to an eye as well as methods related thereto. Such devices and methods allow a desired amount of the treatment medium to be delivered in a controllable manner over a predetermined time period. In particular embodiments, the delivery device is configured and arranged so the treatment medium is eluted from one portion of the delivery device and so that another portion thereof is removably secured within a natural opening or orifice in or proximal to the eye. In specific embodiments the another portion is configured and arranged so as to be removably secured within the natural opening comprising at least one punctum of an eye.
    Type: Application
    Filed: July 1, 2005
    Publication date: May 7, 2009
    Applicant: FORSIGHT LABS, LLC
    Inventor: Eliot Lazar
  • Publication number: 20080262444
    Abstract: Self-dissolving needle-like or filamentous shape percutaneously absorbable preparations, by which inherently poorly absorbable drugs into the body through the skin is efficiently administered. The preparations are made of at least one material selected from the group consisting of proteins, polysaccharides, polyvinyl alcohols, carboxyvinyl polymers and sodium polyacrylic acids. An active substance contained therein is released in a sustained-release fashion (1) by forming a water-insoluble layer on its surface, (2) by holding the active substance in porous materials, or (3) by imparting a long-acting characteristic to the active substance. The present invention also provides a sheet-like carrier for holding the preparations on at least one of the sides thereof, and a piece of equipment for holding the preparations so as to facilitate the administration of them.
    Type: Application
    Filed: January 30, 2006
    Publication date: October 23, 2008
    Applicant: BIOSERENTACH CO., LTD.
    Inventor: Kanji Takada
  • Publication number: 20080132831
    Abstract: A suppository insertion assembly having a first end having a sealable reservoir member and associated plunger and piston, the reservoir member in first conduit communication with a disposable suppository retaining member, the suppository retaining member having a second conduit means snap fit and securable with the first conduit means of the reservoir member, the reservoir member for receipt of a petroleum jelly cartridge, or similar pressurized fluid, the plunger-piston member of the reservoir member compressing the petroleum jelly cartridge so as to cause petroleum jelly to pass through the first and second conduit means and to exert pressure on the suppository, thereby ejecting the suppository from the suppository retention member into the rectum.
    Type: Application
    Filed: November 30, 2006
    Publication date: June 5, 2008
    Inventor: Charles Temple
  • Patent number: 7267670
    Abstract: A urethral suppository comprising a non-meltable base member sized to prevent insertion of the base member into the urethra, a non-meltable reinforcement projecting from the base member, and a meltable portion formed around a portion of the reinforcement. The meltable portion tapers along the reinforcement and is shaped for cooperating with the action of the periurethral musculature to retain the suppository within the urethra. A method of delivering one or more therapeutic agents to the female urinary tract, the method involving insertion of the urethral suppository into the urethra. A method for manufacturing a reinforced urethral suppository.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: September 11, 2007
    Inventors: S. Grant Mulholland, Paul Zupkas
  • Patent number: 7104968
    Abstract: An applicator for delivering pharmaceutical products or the like to a bodily cavity includes a barrel member having a distal end which is equipped with an opening. The applicator also includes a plurality of petals extending outwardly from the distal end in a generally axial direction. The petals cooperate with the opening so as to form a receptacle for releasably receiving a pharmaceutical product in the distal end of the barrel member. Each of the petals has a truncated flexible tip sized and shaped so as to engage a substantially central portion of the pharmaceutical product such that a large section of the pharmaceutical product extends outwardly beyond the petals so as to facilitate the release of the pharmaceutical product from the receptacle. The device also includes a plunger member for releasing the pharmaceutical product from the receptacle. In accordance with the present invention, the device can be packaged in a package together with the pharmaceutical product received in the receptacle.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: September 12, 2006
    Assignee: McNeil-PPC, Inc.
    Inventor: Paul B. Swick
  • Patent number: 6712784
    Abstract: A drug delivery device includes an insert tube and an elongate plunger. The insert tube has a tubular wall that confines a passage and that has drug entrance and release ends. The drug release end has first and second radial parts, and is provided with a flexible grating that includes sets of first and second flexible strips. The first and second flexible strips extend from the first and second radial parts of the drug release end, respectively. The elongate plunger has a drug pushing end and an operating end, is slidably movable in the passage, and has a length sufficient to enable the drug pushing end to push a drug in the passage to move out of the passage and spread apart the first and second flexible strips for delivering the drug into a body cavity.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: March 30, 2004
    Inventor: Deborah Huang
  • Patent number: 6693135
    Abstract: The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a prostaglandin E1 composition of a semi-solid consistency, as well as suitable applicators. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)-alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C1 to C8 alcohol, aliphatic C2 to C30 ester, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: February 17, 2004
    Assignee: NexMed (Holdings) Incorporated
    Inventors: James L. Yeager, Nadir Buyuktimkin, Servet Buyuktimkin
  • Publication number: 20030191439
    Abstract: A disposable device for transferring an active liquid into a body cavity has sufficient intrinsic consistency for being inserted by being thrust into the cavity. The device includes a central element, that is the source of at least part of the active liquid. The central element is preferably formed from a capsule having a wall that forms a detachable appendage. A peripheral element is arranged around the central element. The peripheral element may be a pad arranged to collect and absorb active liquid delivered into the body cavity by expanding and thereby being urged to press sealingly against mucous membrane of the body cavity.
    Type: Application
    Filed: March 28, 2003
    Publication date: October 9, 2003
    Applicant: Bernard Chaffringeon
    Inventor: Bernard Chaffringeon
  • Patent number: 6558362
    Abstract: The invention concerns a disposable device (1) for transferring an active liquid into a body cavity (2), having sufficient intrinsic consistency for being inserted by being thrust into said cavity, said device comprising: a central element (3), at the source of at least part of the active liquid, a peripheral element (4) arranged around the central element, comprising a pad (5) arranged to collect and absorb the active liquid delivered into the body cavity, by expanding and thereby being urged to press sealingly against the mucous membrane of the body cavity (2). The central element (3) comprises a substrate relatively solid at room temperature outside the body cavity, and turning relatively liquid inside the body cavity, such that therein, said central element is liquefied at least partly to generate at least part of the active liquid.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: May 6, 2003
    Inventor: Bernard Chaffringeon
  • Publication number: 20030040726
    Abstract: A urethral suppository having a shaft shaped for cooperating with the action of the periurethral musculature to retain the suppository within the urethra, and having a knob extending from an end of the shaft sized to prevent over insertion of the suppository. A method of delivering one or more therapeutic agents to the urethra and associated structures, the method involving insertion of the urethral suppository into the urethra.
    Type: Application
    Filed: October 11, 2002
    Publication date: February 27, 2003
    Applicant: BioMed Innovations, LLC
    Inventor: S. Grant Mulholland
  • Patent number: 6464670
    Abstract: A urethral suppository having a shaft shaped for cooperating with the action of the periurethral musculature to retain the suppository within the urethra, and having a knob extending from an end of the shaft sized to prevent over insertion of the suppository. A method of delivering one or more therapeutic agents to the urethra and associated structures, the method involving insertion of the urethral suppository into the urethra.
    Type: Grant
    Filed: November 10, 1999
    Date of Patent: October 15, 2002
    Assignee: BioMed Innovations, LLC
    Inventor: S. Grant Mulholland
  • Patent number: 6423038
    Abstract: A topical anesthesia device comprising an injection device having a plunger at one end and an injection opening at the other end. A hollow tube is attached to the injection opening of the injection device. The tube is curved towards the distal tip, having multiple orifices, one orifice being at the distal tip of the tube and remaining orifices being in the sidewalls of the tube. The tube is inserted through the vagina until the resistance of the fundus is perceived and the injection device is operated to permit the anesthetic to exit the orifices on the sidewall of the tube in the region of the tubal ostium and/or the comua of the uterus such that the anesthetic displaces intrauterine debris to reach the mucosal surface of the uterus. The topical anesthesia device provides a significant improvement over the efficiency of the conventional intra-uterine anesthesia devices.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: July 23, 2002
    Inventor: Thierry G. Vancaillie
  • Patent number: 6364854
    Abstract: An applicator for semi-solid medications comprises a tubular body (20) having a rounded dispensing end (21) provided with at least one opening (26) and a grasping end (22), the inner surface of a proximal portion of said tubular body defining a reservoir for the medication, a plunger (30), initially housed inside the tubular body, which plunger is provided with a rod (31) and grasping means (33), a piston (40), positioned in sealing contact with the inner surface of said tubular body providing a closure for the medication reservoir, wherein said piston has a longitudinal hole (45) through which rod (31) of the plunger is disposed, and wherein said piston initially abuts on a stop means (25) when the applicator is received by the user, a coupling means (35, 46) between rod (31) and piston (40), a closure means for sealingly closing off said opening (26) on said dispensing end, wherein the plunger (30) is extractable from the tubular body until the rod (31) becomes engaged with the piston (40) by the coupling m
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: April 2, 2002
    Assignee: J. Uriach & CIA. S. A.
    Inventors: Francisco Ferrer, José Ignacio Izquierdo, Javier Forn, Javier Segado
  • Publication number: 20010016716
    Abstract: A method of delivering one or more therapeutic agents comprising providing a suppository comprising one or more therapeutic agents and a biocompatible carrier medium and shaped to be capable of cooperating with the periurethral musculature to retain the suppository in place in the urethra, inserting the suppository into the urethra, and retaining the suppository within the urethra by the action of the periurethral musculature for a period of time sufficient to permit the therapeutic agent to diffuse substantially into the urethra, the referred suppository comprising a shaft having a first end and a second end and shaped to be capable of cooperating with the action of the periurethral musculature to retain the suppository within the urethra and a substantially ellipsoidal knob extending from the second end of the shaft and sized to prevent insertion into the urethra.
    Type: Application
    Filed: September 9, 1998
    Publication date: August 23, 2001
    Inventor: S. GRANT MULHOLLAND
  • Patent number: 6190348
    Abstract: A disposable applicator for implanting medicaments of various kinds into the human body without exposure of either the user or the recipient to pathogens of the other, and without exposure of either to latex rubber proteins. Differing variants may be sized variously for infants, children and adults, with various stop means for preventing insertion beyond a desired distance. In addition, other variants are particularly suited for use by untrained personnel or by persons with physical conditions which restrict their range of motion. A particularly preferred variant is sufficiently flexible so as to conform to body contours, thereby neither destroying nor irritating possibly sensitive skin tissue.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: February 20, 2001
    Inventors: Harris A. Tiemann, Phillip D. Sharp
  • Patent number: 6168576
    Abstract: A hand-operated disposable device for controllably dispensing medications having a paste-like or cream-like consistency includes a transparent plastic container member having a cylindrical medication-holding bore, and a plunger member which slidably engages the bore. The bore has a series of annular grooves corresponding to incremental volumes of the bore, and the plunger has a lip which interacts with the grooves.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: January 2, 2001
    Inventor: Irene N. Reynolds
  • Patent number: 6093181
    Abstract: Erectile dysfunction, particularly impotence, priapism and Peyronie's disease is treated by the transurethral administration of a therapeutically effective agent. The agents are administered to the urethra by means of a penile insert (1) having a rapidly releasing coating (4) containing the agent on its exterior surface or by means of an inserter (27) carrying an agent containing dose of agent (31) which can be displaced into the urethra.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 25, 2000
    Assignee: Vivus, Inc.
    Inventors: Virgil A. Place, Robert M. Gale, Randall G. Berggren
  • Patent number: 6087396
    Abstract: Oxybutynin chloride formulations having increased stability at body temperature, even at high concentrations. These formulations comprise oxybutynin chloride at a pH of between 3.0 and 5.0, and may include a buffer capable of providing adequate buffering capacity in this range. The OC solutions can be placed in an infuser device for treatment of bladder dysfunction.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: July 11, 2000
    Assignee: Situs Corporation
    Inventor: Dennis H. Roberts
  • Patent number: 5860916
    Abstract: A dissolvable tip 20 or 40 for a colon hydrotherapy speculum system 100 that replaces the function of an obturator. The dissolvable tip 20 or 40 is made of a body of dissolvable material wherein a surface of the tip 20 or 40 is inserted and snugly fit into an inserting end 17 of a speculum 10 while another surface of the tip 20 or 40 with the speculum 10 is inserted into the anal, rectal, or colon canal 91 of a patient 90. The dissolvable tip 20 or 40 is held at the inserting end 17 of the speculum 10. One embodiment of the present invention discloses the dissolvable tip 20 as a pill shaped and egg shaped tip. Another embodiment of the present invention discloses the dissolvable tip 40 as similar in shape to dissolvable tip 20, but the dissolvable tip 40 further has a circumferential bulge 44 in its body wherein the circumferential bulge 44 has an edge that contacts the perimeter of the inserting end 17 of speculum 10 to allow a further snug attachment between the dissolvable tip 40 and the speculum 10.
    Type: Grant
    Filed: April 24, 1996
    Date of Patent: January 19, 1999
    Inventor: Gary Lee Pylant
  • Patent number: 5709652
    Abstract: The present invention relates to an insertion device formed of a tubular element capable of substantially containing an insertable element. The tubular element has an insertion end and a gripper end. The gripper end has a plurality of finger-accepting apertures. These apertures are dimensioned to accept a portion of a user's finger. This device is particularly useful in a tampon applicator tube which has a high-gloss outer surface.
    Type: Grant
    Filed: June 28, 1995
    Date of Patent: January 20, 1998
    Assignee: McNeil-PPC, Inc.
    Inventor: Andrew J. Hagerty
  • Patent number: 5676647
    Abstract: A tampon applicator including an insertion tube for accepting a tampon and a discharge tube for discharging the tampon. The discharge tube is displaceable in the insertion tube. Placeable upon the end area of the insertion tube on the insertion side is a container containing a therapeutic or prophylactic medicinal substance. This container is sealed off from the insertion tube by means of a foil. Provided in the insertion tube between an accepted tampon and the foil are pivotable flaps having a sharp-edged projection, and which are pivoted during insertion of the tampon by means of the forward movement of the tampon against the foil and which break through the foil with their sharp-edged projection.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: October 14, 1997
    Inventor: Hugo Cimber
  • Patent number: 5656283
    Abstract: This invention relates to a novel method of manufacturing a lyophilized suppository composition wherein said suppository is made in situ in an applicator cartridge.
    Type: Grant
    Filed: June 8, 1995
    Date of Patent: August 12, 1997
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Barbara Brummer, Paul Swick, Martin Link, William Hart
  • Patent number: 5593422
    Abstract: Occlusion assembly for sealing openings in blood vessels, consisting of an occlusion element and fixing element to be fitted through the openings in the blood vessel. The fixing element is firmly connected to a retaining element. A locking element engages on the retaining element. This locking element is fitted horizontally against the outside of the blood vessel.
    Type: Grant
    Filed: January 6, 1995
    Date of Patent: January 14, 1997
    Inventors: Wouter M. Muijs Van de Moer, Rienk Rienks