Abstract: An access port for subcutaneous implantation is disclosed. Such an access port may comprise a body for capturing a septum for repeatedly inserting a needle therethrough into a cavity defined within the body. Further, the access port may include at least one feature structured and configured for identification of the access port subsequent to subcutaneous implantation. Methods of identifying a subcutaneously implanted access port are also disclosed. For example, a subcutaneously implanted access port may be provided and at least one feature of the subcutaneously implanted access port may be perceived. Further, the subcutaneously implanted access port may be identified in response to perceiving the at least one feature.

Abstract: An assembly for identifying a power injectable vascular access port, including a vascular access port and an identification feature. The port is structured for power injection and includes a housing and a septum together defining a reservoir. A radiographic feature incorporated into the port is perceivable via x-ray following subcutaneous implantation, the radiographic feature identifying the port as suitable for flowing fluid at a fluid flow rate of at least 1 mL/sec therethrough. A structural feature of the port is perceivable via palpation following subcutaneous implantation, the structural feature identifying the port as suitable for accommodating a pressure within the reservoir of at least 35 psi. The identification feature is separated from the port and confirms that the port is both suitable for flowing fluid at a rate of at least 1 mL/sec therethrough and suitable for accommodating a pressure within the reservoir of at least 35 psi.

Abstract: A capsule configured for in vivo refilling of a thereapeutic agent. In certain embodiments, the capsule may contain methotrexate.

Abstract: An implantable port includes a body with a reservoir in the body, a tunnel extending from the reservoir to an outer surface of the body, a pivoting coupling connected to the body near the tunnel on the outer surface, and a stem connected to the pivoting coupling.

Abstract: A connector and method of connecting are described for connecting a first and second catheter at an overlap area where the first catheter fits within the second catheter. The connector includes a collar that surrounds a portion of the overlap area and a clamp that applies a radially inward force to the collar and encircles a portion of the overlap area.

Abstract: A connector and method of connecting are described for connecting a first and second catheter at an overlap area where the first catheter fits within the second catheter. The connector includes a collar that surrounds a portion of the overlap area and a clamp that applies a radially inward force to the collar and encircles a portion of the overlap area.

Abstract: The invention relates generally to implantable drug delivery devices. Devices having a single drug chamber configuration, a divided drug chamber configuration and a compact dual-drug configuration are described. The devices have features to prevent clogging of the dispensing catheter and the creation of a local vacuum caused by the dispensing of the drug fluid. Also provided are features of a failsafe refilling process, automatic refill notification, and performance verification process. The divided drug chamber configuration enables frequent or continuous minute doses. A dual-drug chamber configuration uses self-locking refill containers to prevent mismatching between refill containers and drug chambers.

Abstract: Implantable infusion devices and systems with side port access detection capability and methods of detecting side port access. The methods may include the steps of sensing pressure in a fluid passage between an implanted pump mechanism and an implanted outlet port and determining that an implanted side port has been accessed by a hypodermic needle based on a predetermined change in pressure in the fluid passage between the implanted pump mechanism and the implanted outlet port.

Abstract: A multi-port assembly includes a base with a surface, a port receiving area on the surface, and a port coupling connected to the base. The port receiving area is adapted to receive a mating surface of a port, and the port coupling is adapted to mate the port to the port receiving area.

Abstract: A method for implanting an injection port within a patient. The method involves providing a port having a housing with a closed distal end, a open proximal end, a fluid reservoir therebetween, a needle penetrable septum attached to the housing about the opening, and at least one attachment mechanism mounted to the housing at a pivot point along an outer periphery of the housing. The attachment mechanism is an arcuate hook pivotable with respect to the housing, the arcuate hook having a length extending substantially at least 180° about the pivot point. The method further involves placing the distal end of the port adjacent tissue, and rotating the arcuate hook at least 180 degrees so that a free end of the hook extends into tissue and back out again.

Abstract: A medical device comprises a flexible member that can be adhesively attached to a housing of the medical device, allowing implantation of the medical device into a body through an incision of reduced size. The flexible member can be attached to the housing either before or after implantation into the body. The flexible member comprises suture locations, including a permeable membrane or a suture hole, for suturing the medical device to tissue of the body. The suture holes can be filled with a substance penetrable by a suture needle, to minimize tissue ingrowth before or after suturing.

Abstract: A number of parameters related to the operation of a fluid delivery device are determined based on pressures within the device sensed using multiple pressure sensors. In one example, the volume of therapeutic fluid within a reservoir of a fluid delivery device is estimated based on a measured pressure differential. In another example, the rate at which a therapeutic fluid is added to or removed from the reservoir is estimated based on the measured pressure differential.

Abstract: Assemblies for identifying a power injectable vascular access port are described. One assembly includes a vascular access port, a first identifiable feature, a second identifiable feature, and a third identifiable feature. The first identifiable feature is incorporated into the access port and identifies the access port as suitable for flowing fluid at a fluid flow rate of at least 1 milliliter per second through the access port. The second identifiable feature is incorporated into the access port and identifies the access port as suitable for accommodating a pressure within the cavity of at least 35 psi. The third identifiable feature is separated from the access port and confirms that the implanted access port is both suitable for flowing fluid at a rate of at least 1 milliliter per second through the access port and for accommodating a pressure within the cavity of at least 35 psi.

Abstract: A needle and needle system that aids in determining needle position with respect to an implanted device. The system determines needle position by detecting changes in electrical characteristics and the system further may generate a cue to indicate proper needle placement within an implanted device. Methods for detecting needle position with respect to an implanted infusion device are also disclosed.

Abstract: Ports for accessing a vessels within a patient include passageways that can guide needles or other access devices directly into the vessels. The ports can be implanted subcutaneously within a patient. Some ports may be used in the creation and use of vascular access buttonholes.

Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

Abstract: The present invention includes systems and methods for detecting fluid flow into or out of a port chamber or a reservoir of an implantable medical device utilizing a pressure sensor. The system detects characteristic pressure profiles associated with fluid flowing into the medical device, out of the medical device, and also whether one or both of the port chamber or reservoir are substantially empty or substantially full. In addition, the present invention may generate a sensory cue to a clinician to indicate the fluid status.

Abstract: A needle apparatus for aligning a needle with a port of an implantable infusion device includes a needle anchoring portion configured to axially fix the apparatus relative to a needle to be inserted into the port. The needle apparatus further includes a port locating portion fixable relative to the needle anchoring portion. The port locating portion includes a port location signal receiver module for receiving a signal from an implantable infusion device regarding the location of the port of the infusion device.

Abstract: The invention relates to implantable vascular access ports that can release agents such as antibiotics, anti-thrombogenics and anti-proliferatives. The invention also relates to ports having locking mechanisms that prevent accidental disengagement, and structures that facilitate surgical implantation and provide for long-term stability and use of the port.

Abstract: An access port for subcutaneous implantation is disclosed. Such an access port may comprise a body for capturing a septum for repeatedly inserting a needle therethrough into a cavity defined within the body. Further, the access port may include at least one feature structured and configured for identification of the access port subsequent to subcutaneous implantation. Methods of identifying a subcutaneously implanted access port are also disclosed. For example, a subcutaneously implanted access port may be provided and at least one feature of the subcutaneously implanted access port may be perceived. Further, the subcutaneously implanted access port may be identified in response to perceiving the at least one feature.

Abstract: A method may include placing a first device on a first side of a skin portion of a subject and transferring a material through the skin portion of the subject from the first device to a subdermal second device disposed on a second side of the skin portion of the subject.

Abstract: The present invention provides an improved vascular access port comprising a port base with a metallic dish insert molded (or bonded) into the bottom of the reservoir. In one embodiment, a single reservoir is provided. In another embodiment, plural reservoirs are provided. The metallic bottom of the reservoir provides a hard surface that will resist abrasion and puncture by the access needles used to infuse medication or withdraw blood. Additionally, the single and dual ports can include exit ports that are intended to better anatomically fit into the subcutaneous areas around muscle tissue.

Abstract: A surgically implantable medical port has a housing with a fluid reservoir therein, a tubular stem extending away from the housing, a fluid conduit mounted on the stem, and a plurality of cantilevered fingers having free ends that are pressed against the fluid conduit in order to prevent conduit detachment from the port. The cantilevered fingers may be provided in a retention sleeve positioned about the fluid conduit. The retention sleeve may be unitarily formed with the housing of the port. The retention sleeve may be formed by at least two separate pieces, such as sections that pivot open and closed relative to the housing and that snap together in a closed position.

Abstract: A support tool for a supply assembly delivers a functional fluid to an implantable medical device. The supply assembly defines a supply axis. The support tool includes a support member defining an opening. The opening has a support axis, and the opening is configured to receive the supply assembly. The support member includes a three dimensionally contoured nesting surface that conforms to a corresponding three dimensionally contoured surface of the supply assembly. The corresponding surface of the supply assembly nests against the nesting surface to support the supply assembly such that the supply axis remains substantially fixed relative to and aligned with the support axis.

Abstract: Assemblies for identifying a power injectable vascular access port are described. One assembly includes a vascular access port, a first identifiable feature, a second identifiable feature, and a third identifiable feature. The first identifiable feature is incorporated into the access port and identifies the access port as suitable for flowing fluid at a fluid flow rate of at least 1 milliliter per second through the access port. The second identifiable feature is incorporated into the access port and identifies the access port as suitable for accommodating a pressure within the cavity of at least 35 psi. The third identifiable feature is separated from the access port and confirms that the implanted access port is both suitable for flowing fluid at a rate of at least 1 milliliter per second through the access port and for accommodating a pressure within the cavity of at least 35 psi.

Abstract: The present invention relates to an apparatus, system and method for, and for providing, intraocular delivery of an active agent. The apparatus, system and method may include an implantable scaffold and an active agent associated with the implantable scaffold. The implantable scaffold and the active agent may be configured to be completely contained within the eye upon implantation. The implantable scaffold may be a mechanical scaffold, or the implantable scaffold may be a chemical scaffold.

Abstract: The present invention is directed to a subcutaneous controlled delivery device that provides for a refillable reservoir port, a release mechanism and tubing that operably connects the reservoir port to the release mechanism. Such a device is capable of being implanted under the dermis of the skin and allows for the controlled release of drugs, biological agents or therapeutic agents to a target site of interest in the body for treatment.

Abstract: An implantable port with a high-flow stem for fluid access to a site within a human body is disclosed. The port has a reservoir and a needle-penetrable septum for access to the reservoir. The port also has a stem with multiple cylindrical lumens extending through the length of the stem, and each cylindrical lumen is in fluid communication with the reservoir.

Abstract: An implantable medication delivery device that is highly space efficient and can reliably and safely deliver controlled medication doses to a target site. The system includes a variable volume medication reservoir that is exposed to an ambient pressure equal to the ambient pressure at a system outlet port. A pump/valve subassembly is provided to draw medication from the reservoir and force a medication dose along a fluid transfer passageway to the outlet port. The pump/valve subassembly incorporates a safety mechanism, e.g., a balanced valve, which normally blocks medication flow to the outlet port and opens only in response to a pump induced unbalancing force. A protective shell is also disclosed for protecting the ambient reservoir.

Abstract: A vascular access port is described that is elongate in form. A distal end is coupled to a tube which leads into a body lumen. A proximal end has a head thereon with a septum which can be repeatedly penetrated by a needle and reseal, for repeated administration of medications or other compositions through the port and into the body of the patient. A wing is attached to the body that has two positions including a streamlined first position for implantation and a wider second position for stabilization of the port after implantation. A stay is preferably also provided to abut the wing when in the second position to keep the wing in the second position when fully deployed.

Abstract: An access port for the introduction of a needle cannula tip into an IV tube set includes a rigid tubular housing and a resilient member disposed adjacent an inlet of the housing. The resilient member includes an axial perforation extending through the resilient member, and is normally closed by the resilient character of the resilient member. A depression is defined in a proximal face of the resilient member, and includes sidewalls extending between the proximal face and the axial perforation to guide the tip of the cannulated needle toward the perforation as the cannulated needle is introduced into the access port.

Abstract: An insertion device for inserting an infusion device at least partially into skin for subcutaneous infusion can comprise a sleeve having a lower surface that is configured to engage the skin, a shuttle or carriage to carry the infusion device between a retracted position and an advanced position; at least a first biasing member to urge the shuttle or carriage toward the advanced position, and an actuator to cause the first biasing member to urge the carriage from the retracted position to the advanced position. In some embodiments, the insertion device can further comprise a hub and at least a second biasing member to urge the hub away from the shuttle or carriage. In some embodiments, the insertion device can further comprise a needle attached to the hub. Methods for inserting an infusion device and various other features that can be comprised by an insertion device are also disclosed.

Abstract: The present invention provides an improved vascular access port comprising a port base with a metallic dish insert molded (or bonded) into the bottom of the reservoir. In one embodiment, a single reservoir is provided. In another embodiment, plural reservoirs are provided. The metallic bottom of the reservoir provides a hard surface that will resist abrasion and puncture by the access needles used to infuse medication or withdraw blood. Additionally, the single and dual ports can include exit ports that are intended to better anatomically fit into the subcutaneous areas around muscle tissue.

Abstract: A surgical fastening system for implantable devices such as injection port systems. The implantable device may contain a plurality of fasteners in pre-deployment position, may have a housing fitted over or around it which contains a plurality of fasteners in pre-deployment position, or may be a part of a two-part system into which it fits. Accordingly, the present invention also encompasses a deployment system or tool that optionally positions the implantable device, and which causes the fasteners to move into post-deployment position. The fasteners may be staples, metal loops, coils, springs or hooks formed of biocompatible materials, including shape memory alloys such as NiTi.

Abstract: An implantable infusion port comprising a non planar septum, a fluid reservoir of a substantially spherical shape, inlet means to access the reservoir, and optimized outlet means from the reservoir. The present invention provides for a reservoir that precludes angular junctions between portions of the reservoir which can lead to eddies, countercurrents, and stagnation, thereby creating a more laminar and efficient flow pattern within the reservoir.

Abstract: The invention relates to an implantable medical device for injecting and/or collecting fluid substance into and/or from a human or animal organism, said device comprising a casing (6) whose wall (3) delimits a chamber and is pierced with at least a first access orifice (7) designed to allow a needle to pass through said wall (3), said device being characterized in that the first access orifice has a staged structure comprising: a guide portion designed to limit the angular clearance of the needle when said needle is engaged therein, and a flared intake portion that forms a continuation of the guide portion, so as to be able to cause the trajectory of the incoming needle to converge on the guide portion. Implantable medical devices.

Abstract: An access port, wherein the access port may include a body having an exterior surface and a chamber defined therein, a bore defined in the body providing fluid communication between the chamber and the exterior surface, a needle in fluid communication with the chamber, a passage defined in the body providing communication between the chamber and the exterior surface, a seal secured within the passage, and an actuator in communication with the needle, configured to move the needle relative to the passage or move the passage relative to the needle.

Abstract: A totally implantable venous device includes a port, a catheter and a sleeving member. The port includes an arcuate housing having a recess on an inner surface, an opening communicating with the recess and having a flat mouth, an internal chamber, and a base formed of hard plastic and being capable of preventing a needle from being inserted therethrough. The catheter includes an enlarged fastening member at one end. The sleeve is complementarily mounted on a front portion of the enlarged fastening member. The sleeving member is complementarily mounted on the remaining portion of the enlarged fastening member. The recess and the opening form a through hole having an enlarged intermediate portion. The enlarged fastening member has a truncated trapezoidal shape. The sleeving member, the enlarged fastening member and a connector of a receiving seat in the port form a watertight structure at the through hole.

Abstract: A method may include placing a first device on a first side of a skin portion of a subject and transferring a material through the skin portion of the subject from the first device to a subdermal second device disposed on a second side of the skin portion of the subject.

Abstract: A medical port includes a main channel with a lumen to conduct a first fluid through the port, a secondary channel aperture of a secondary channel to add a second fluid in the main channel, at least one housing element and at least one actuation element arranged to be transferable relative to the housing element from a first position into a second position, a seal section, which is arranged to be rotatable between a first position of the seal section, in which the seal section does not close, seal or cover the secondary channel aperture and a second position of the seal section, in which the seal section closes, seals or covers the secondary channel aperture, when the actuation element is transferred from the first position to the second position. A blood hose including at least one port, and a medical treatment apparatus are also described.

Abstract: An implantable delivery device including a housing, a port assembly, and a plurality of grooves. The housing includes an outer wall defining an exterior face. The port assembly includes a septum and a port opening that is exteriorly open relative to the housing face. The plurality of grooves are formed in the exterior face proximate the port opening, and are sized to receive a needle tip to guide the needle tip toward the port opening. In one embodiment, the port assembly is fluidly connected to a reservoir, such that the port assembly constitutes a reservoir refill port.

Abstract: A medical implant includes a flexible container having two layers of flexible surrounding walls, each surrounding wall being provided with a plurality of through holes; a tubular fitting being connected to an open end of the flexible container for inserting or infusing a medical filling material into the flexible container through the tubular fitting; and a thrust part connected to the flexible surrounding walls of the flexible container and at a distal end of the flexible container. The thrust part has a receiving seat and a ring, the receiving seat having a central bore and an annular groove surrounding the central bore and opposite to the central bore, wherein a tubular surrounding wall is inserted into the ring and is folded so that the two layers of flexible surrounding walls are formed with the ring imbedded between the two layers of flexible surrounding walls, and the ring with the two layers of flexible surrounding walls are received in the annular groove and detained therein due to friction.

Abstract: Ports for accessing a vessels within a patient include passageways that can guide needles or other access devices directly into the vessels. The ports can be implanted subcutaneously within a patient. Some ports may be used in the creation and use of vascular access buttonholes.

Abstract: The invention relates to an implantable medical device (1) for injecting and/or collecting fluid substance into and/or from an organism and comprising a chamber (2) delimited by a wall (3) which has at least one pierceable portion (4) in the area of which said wall (3) can be pierced through in the direction of its thickness (e) by a needle (5), said device comprising means (10) for transverse compression of the pierceable portion (4), and also retention means (20) designed to oppose the buckling, towards the outside of the device, experienced by the pierceable portion (4) under the effect of the compression (F1).

Abstract: Antibody complexes including anti-A? antibodies conjugated with a sialic acid-containing molecule show improved bioavailability with no significant adverse effects on binding to amyloid beta.

Abstract: In one aspect, the present invention provides implantable or insertable urological medical devices, which are adapted to deliver one or more urologically beneficial agents in pharmaceutically effective amounts. In one aspect, the invention provides medical devices in which urologically beneficial agents are delivered using a porous membrane.

Abstract: An intravascular port access device includes a first component having a chamber configured to attach reversibly to an intravenous line port. A second component reversibly attaches to the first component and contains a disinfecting agent and an applicator material. The second component is configured to be reversibly received over external surfaces of the intravenous line port. A method of cleansing an intravenous line port includes providing a port cleaning device having a first component with a chamber containing a first cleaning agent. A second component includes a second cleaning agent. A third component has a microbiocidal agent and is reversibly attached to the first component. The second component is removed from the device, the external surfaces of the port are contacted with the second cleaning agent, the first cleaning agent is ejected from the chamber into the port, and the third component is used to cap the port.

Abstract: An access port for providing subcutaneous access to a patient is disclosed. In one embodiment, the port includes an internal body defining a fluid cavity that is accessible via a septum. A compliant outer cover including silicone is disposed about at least a portion of the body. A flange is included with the port body and is covered by the outer cover. The flange radially extends about a perimeter of the port body proximate the septum so as to impede penetration of a needle substantially into the outer cover in instances where the needle misses the septum. The flange can further include both an anchoring feature for securing the outer cover to the port body and an identification feature observable via x-ray imaging technology for conveying information indicative of at least one attribute of the access port. The outer cover provides a suitable surface for application of an antimicrobial/antithrombotic coating.

Abstract: A surgical fastening system for implantable devices is disclosed. The implantable device may contain a plurality of fasteners in pre-deployment position, may have a housing fitted over or around fit which contains a plurality of fasteners in pre-deployment position, or may be a part of a two-part system into which it fits. Accordingly, the present invention also encompasses a deployment system or tool that optionally positions the implantable device, and which causes the fasteners to move into post-deployment position. The fasteners may be staples, metal loops, coils, springs or hooks formed of biocompatible materials, including shape memory alloys such as NiTi.

Abstract: The invention relates an implantable access device for a catheter for supplying an active substance to an active site. The inventive access device comprises a chamber which is arranged in a housing for receiving the active substance and is closed with a piercable membrane. A connecting piece, to which the catheter is connectable, is fluidly connected to the chamber. The catheter is fixed by clamps that are fixable to the housing preferably by means of elastic fixing arms. The chamber receiving the active substance is embodied in an insertion element that is arranged in a recess of the housing by an intermediate clamping of the intermediate layer of the membrane in such a way that the insertion element produces a pressure force to said membrane.