Abstract: A reduced-pressure, wound closure system is presented that generates a closing force on a surface wound and optionally provides reduced pressure to a body cavity or tissue site. The sealed contracting member, when placed under reduced pressure, generates the closing force. One illustrative system includes a first attachment member and a second attachment member, a sealed contracting member coupled to the first attachment member and the second attachment member, and wherein the closing force is generated between the first attachment member and the second attachment member when reduced pressure is supplied to the sealed contracting member. Other systems and methods are presented.

Abstract: A flexible protective cover for preventing fluid from entering an open epidermal site on a user, comprising: a central portion having at least one rib, an edge connected to the central portion at an angle, a lip disposed around the edge, a sealing member disposed over the lip for providing a sealing engagement between the lip and the open epidermal site, and at least one adjustable strap removably connected to the central portion. Also disclosed is a flexible protective cover having a central portion, an edge connected to the central portion at an angle, an inflatable sealing member integral with the edge for providing the sealing engagement, and at least one adjustable strap removably connected to the central portion.

Abstract: A wound dressing includes an absorbent core defining opposed proximal and distal surfaces including a central portion and a border portion, and a liquid impervious, vapor permeable backing layer connected to the distal surface of the absorbent core. The backing layer defines a border portion extending beyond the periphery of the absorbent core. A skin adherent, perforated facing layer is secured to the proximal surface of the absorbent core. An adhesive layer is applied to at least a proximal segment of the border portion of the backing layer and has greater skin adherence properties than the facing layer.

Abstract: A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient or with infusion media are supported by the disposable housing portion for disposal after the prescribed use, while the durable housing portion supports other components such as electronics for controlling delivery of infusion media from the reservoir and a drive device and drive linkage.

Abstract: A transdermal drug delivery device is shown and described. The device includes an occlusive or non-occlusive backing, an adhesive, at least one drug delivery region, an adhesive, and a release liner. The device has an open configuration and a closed configuration. When the device is in the closed configuration, the adhesive, the at least one drug delivery region, and the release liner are disposed between first and second portions of the backing.

Abstract: An adhesive patch containing an adhesive patch main part containing a support and an adhesive layer laminated on the support, wherein the adhesive patch main part comprises a peripheral part, a central part, and an intermediate part between the peripheral part and the central part, the intermediate part of the adhesive patch main part has a thickness greater than that of the central part of the adhesive patch main part, and the central part of the adhesive patch main part has a thickness greater than that of the peripheral part of the adhesive patch main part, and a production method thereof.

Abstract: A reduced pressure treatment apparatus includes a drape for positioning over the wound site to create and maintain a substantially air-tight cavity between the wound site and the drape. A multi-lumen suction tube is provided to be attached to a reduced pressure source. The multi-lumen suction tube includes a center lumen and at least one outer lumen and is configured to deliver reduced pressure beneath the drape to the substantially air-tight cavity. The multi-lumen suction tube is adapted to allow fluid to be drawn from the wound site through the center lumen and pressure to be monitored at the wound site through the at least one outer lumen.

Abstract: A dermal, transdermal, mucosal or transmucosal delivery device includes a backing layer overlying an ingredient containing reservoir, and having a microprotrusion array attached thereto, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the skin or mucosa.

Abstract: An integrated wound dressing system and method including a bandage and a self-contained receptacle that stores treatment material for the care and treatment of wounds. The treatment material is easily accessible and can be removed from the receptacle through an exit. The treatment material can then be used to control bleeding and/or clean the wound before dressing. The bandage may include a layer of plastic that acts as an occlusion barrier to reduce heat loss and maintain moisture levels at the wound site. The occlusion barrier also acts to prevent the passage of air into or out of the wound site. The bandage also includes fasteners that act to prevent unintentional unraveling and to secure the bandage during final packaging. These fasteners help facilitate the wrapping of amputations, stumps, and extremities. The integrated wound dressing system provides an all-in-one system for treating and dressing wounds and reduces the time required to do so.

Abstract: Maggot debridement therapy dressing embodiments and methods are discussed for the treatment of a variety of indications including wound care, including septic wound care and the like.

Abstract: A dressing having a flexible sleeve shaped to accommodate a substantially cylindrical body or plant portion, the sleeve having a lining which is substantially non-adherent to the body or plant part being bandaged and having a peripheral securement means which attaches two peripheral portions to each other without those portions being circumferentially adhered to the sleeve portion.

Abstract: A packaging bag 1 according to the present invention comprises a pair of packaging films 7x, 7y that are disposed facing one another, and are sealed together around a perimeter thereof so as to form a housing portion 9 housing a plaster. On one of the packaging films 7x is provided a protrusion 10 that protrudes toward the other packaging film 7y. When the plaster 2 is packaged, only the protrusion 10 of the packaging film 7x contacts a plaster body 5. The portion contacted by the protrusion 10 is a portion, on the inside of the plaster body 5, that excludes an outer periphery of the plaster body 5. Therefore, even if adhesive sticks out of the outer periphery of the plaster body 5, this adhesive does not contact the packaging film 7x. As a result, the plaster 2 can be easily removed from the packaging bag 1.

Abstract: A method for preventing infection and maintaining aseptic epidermal areas by preventing contaminated fluid from entering an open epidermal site on a user, comprising the steps of: removably attaching at least one adjustable strap to a reusable non-deforming flexible protective cover comprising a sealing member, covering the open epidermal site with the reusable non-deforming flexible protective cover while maintaining a space between the reusable non-deforming flexible protective cover and the open epidermal site, and tightening the at least one adjustable strap to secure the reusable non-deforming flexible protective cove over the open epidermal site to create a fluid-tight seal between the sealing member and the open epidermal site, thereby preventing contaminated fluid from entering the open epidermal site.

Abstract: A solid dispersion transdermal drug delivery system comprising a therapeutic agent in a stable amorphous form and a combination polymeric stabilizing and dispersing agent having a hydrogen bond-forming functional group, and a method of manufacturing these systems is provided. The weight ratio of the combination polymeric stabilizing and dispersing agent to the therapeutic agent is also disclosed.

Abstract: A hospital type of bandage integrates an absorbent pad and non-stick layer with a fluid-impermeable outer layer and an adhesive in a single composite structure. In a preferred embodiment the invention further includes means which may be used to turn the bandage inside out upon removal, so that surfaces once contacting a patient are no longer externally exposed. A bandage according to the invertible embodiment preferably includes a pocket formed on the side of the bandage facing away from the patient after application, this pocket being large enough to accommodate at least a portion of a human hand, and inside this pocket and located opposite the entrance is a means for grasping which may be pulled outwardly through pocket opening, thereby inverting the entire structure. Various forms of devices for grasping are possible as alternatives, including a string, a tab and a tab with one or more finger-receiving holes.

Abstract: A wound therapy device is disclosed. The wound therapy device may include a housing for covering at least a portion of a wound and for sealing to a body surface of a patient. The housing may also include a liquid-retention chamber for retaining liquid therein and a vacuum connection for coupling to a vacuum source. The vacuum connection may be in gaseous communication with the liquid-retention chamber. The vacuum connection may be separated from the liquid-retention chamber by a liquid barrier.

Abstract: A wound closure apparatus is disclosed which includes a housing that contains a vacuum pump and a chamber for holding a disposable wound fluid collection canister. The canister resides within the chamber and connects at an outlet with the vacuum pump and at an inlet with a pad. The pad is placed over a wound and adhesively secured thereto. When the vacuum pump activates, it evacuates air from the canister resulting in wound fluids flowing from the wound into the canister. After the canister is filled, it is removed from the chamber and replaced with another canister to continue the removal of wound fluids.

Abstract: A transdermal patch system configured as a patch or pump assembly may be placed into contact upon a skin surface to transport drugs or agents transdermally via any number of different mechanisms such as microporous membranes, microneedles, in-dwelling catheters, etc. The assembly may enclose or accommodate a reservoir configured as an elongate microchannel to contain the drug or agent suspended in a fluid vehicle. The reservoir may also be fluidly coupled via microchannels to transport the drugs into or against an underlying skin surface as driven or urged via a pump and controlled by an electronic control circuitry which may be programmed to affect any number of treatment regimens.

Abstract: Transdermal delivery systems are disclosed including a backing layer, a polymer membrane within the backing layer, an adhesive layer for attaching the delivery system to the patient's skin or mucosa, and a releasable layer covering the adhesive layer prior to use, the polymer membrane impregnated with sufficient fluid medium to alter the rate of transmission of an active agent through the polymer membrane, with the amount of fluid medium being greater than the amount retained by the fluid membrane upon drying.

Abstract: A film comprising as a film-forming agent an alginate salt of monovalent cation or a mixture of alginate salts containing at least one alginate salt of monovalent cation, the film-forming agent being such that a 10% aqueous solution thereof at a temperature of 20° C. has a viscosity of 100-1000 mPas, as measured at a shear rate of 20 rpm by use of a Brookfield viscometer with a spindle No. 2. A method of preparing the film. The film is useful for delivery of active ingredients to a mammal.

Abstract: A preparation of statins for prolonged release. The preparation is a transdermal therapeutic system or hypodermic implantation system. And they overcome the problem of low bioavailability and increase patient compliance. The statins in the invention contain all of statins and responding salts, hydroxyl ester derivatives at 4-position. The invention has many advantages: for example, reduce dosage frequency, remain stable and lasting blood concentration of medicine, further improve the curative effect, provide patients with a convenient and safety means of administration, and obtain an effective period of up to seven days to months by taking medicine once.

Abstract: A release agent applicator applies release agent to an imaging drum and absorbs release agent metered from the drum to extend the operational life of a image drum maintenance unit. The applicator includes a reservoir for storing release agent, the reservoir having a plurality of perforations for enabling release agent to seep from the reservoir, a containment membrane mounted to the reservoir for wicking release agent from the perforations of the reservoir, and a delivery layer mounted to the containment membrane for delivering release agent from the containment membrane to an imaging drum that is in contact with the delivery layer. The delivery layer is matched to the containment membrane to maintain a saturation rate for the delivery layer in a predetermined range and the delivery layer has an uptake rate for release agent contacting an external boundary of the delivery layer that is greater than a release agent supply rate from the containment membrane to the delivery layer.

Abstract: The invention provides a dressing, method and kit components useful for effectively and conveniently treating skin cracks or other skin conditions requiring a moist healing environment.

Abstract: The present invention refers to a transdermal delivery device comprising a backing layer, at least one adhesive layer, and a release liner coated with a UV-cured highly crosslinked silicone. The present invention also refers to a method of preparing a transdermal delivery device comprising a backing layer, at least one adhesive layer, and a release liner coated with a UV-cured silicone.

Abstract: A muco-adhesive patch for delivery of drugs into mucous membranes. On the muco-contact side, a water impermeable layer covers the center of the patch and less than half of the muco-contact side of the patch. Drugs may be added by mixing the drug with an adhesive material and placing a spot of the drug plus adhesive onto the exposed side of the water impermeable layer. A lenticular medical patch with a thin, tapered edge can be made with multiple layers by passing a single sheet such as a sheet of plastic through a production line in which each layer is applied in turn maintaining registration by reference to edges of the sheet or to marks on the sheet.

Abstract: The present invention aims at provision of a patch with suppressed occurrence of adhesive residue on the skin after peeling in the presence of water due to perspiration and the like. The patch has an adhesive layer provided on at least one surface of a support, and the adhesive layer is formed by blending the following component (A)-component (C): (A) a copolymer obtained by copolymerization of a monomer containing a carboxyl group, (meth)acrylic acid ester and vinylpyrrolidone as essential components; (B) a copolymer obtained by copolymerization of a monomer having a basic group and (meth)acrylic acid ester as essential components; and (C) a liquid component, and crosslinking the blend.

Abstract: A skin-contacting adhesive composition is described which has improved initial tack, long-term adhesion, water uptake and translucency characteristics and may be prepared by melt extrusion. Uses of these compositions are also described, for example, their use in wound dressings, adhesive cushions, and transdermal drug delivery devices.

Abstract: The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.

Abstract: A method and related compositions, including the use of N-acyl derivatives of sarcosine, provide for the delivery of bioactive agents through tissue surfaces such as the skin. The method and composition are particularly well suited for hydrophobic active agents such as serotonin (5HT3) receptor antagonists (e.g., ondansetron), antipsychotic agents (e.g., risperidone), benzodiazepines (e.g., flumazenil), and progestins (e.g., levonorgestrel).

Abstract: A blood leakage detection device for attachment to the skin of a patient at a wound such as one caused by insertion a cannula into a vein or artery comprises a support of a flexible material having a top side and an opposite bottom side, a zone of adhesive for attachment to the skin on the bottom side of the support extending along its periphery except for a sector of from about 5° to about 150°, a blood absorbent patch disposed on the support and extending inwardly of the adhesive zone and, optionally, in the sector, and a blood detection probe comprising a probe head disposed at or near the centre of the support in the absorbent patch or abutting the bottom side thereof. A blood transport element can be disposed between the support and the absorbent patch.

Abstract: A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.

Abstract: The present invention provides a patch package structure, which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, the first and second sheet materials being sealed together in peripheral parts thereof, and a patch disposed in the package, in which the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer; the second sheet material has been molded so as to have a protrudent part in at least a substantially central area thereof, the protrudent part having a planar outer shape larger than a planar outer shape of the release liner and having at least one recessed part; d is not smaller than T, in which d is the minimum gap distance between the inner surface of the first sheet material and the inner surface of the second sheet material at the recessed part and T is a thickness of

Abstract: The invention consists in a medication made up of an adhesive strip on one side on which a pad is applied and to which a container is integral with it (5) where a disinfectant substance or any other type is inserted in its internal part, in such a way that by opening the container in a certain point, the substance goes to be applied onto the pad itself, soaking it in case that we are dealing with a liquid substance. The part of the container (5) destined to be opened is directly in contact with the above-mentioned pad. The inferior part of the invention, containing the pad and the adhesive part, is covered by one or more strips of the plastic film or membrane, which can incorporate the above-mentioned container or tank which is removed before applying the medication to the body.

Abstract: One aspect of the invention is a method of treating a wound to clot blood. A sponge material is applied to the wound. The sponge comprises a starch having hemostatic properties and at least one binding agent. The sponge may further comprise a porous, flexible material.

Abstract: A protector effectively suppresses infections. The protector protects a tube entry part, where a tube passes through the skin of a living body, from infections, and includes a sticking part that is stuck onto the skin of the living body in a periphery of the tube entry part, and a covering that covers the tube entry part, forms an internal space that surrounds the tube entry part, and has a passage through which the tube passes. The covering is provided with an opening that can be freely opened and closed with a cap or the like.

Abstract: A wound dressing that includes two layers for a two part solution to the needs of a healing skin wound. The first step involves a relatively closed system wherein moisture is kept near the skin to promote healing. The second step allows for removal of a top layer of the dressing to reveal a layer with a series of apertures that allows for 100% moisture vapor and oxygen transmission rates to avoid irritation and itching of the skin. At the same time, the bottom layer of the wound dressing maintains a significant outer perimeter that prevents the perimeter migration of microorganisms into the healing wound. The wound dressing can also be used as a means for securing medical instruments, such as intravenous catheters, to the skin of a patient while avoiding the itching and irritation associated with traditional methods.

Abstract: The invention relates to a dressing or bandage comprising a dispersion of at least one transition metal in an imogolite or allophane matrix. In particular, it is intended for the manufacture of transparent dressings.

Abstract: A multiple-pouch package includes a first pouch wherein is fixed a support impregnated with a substance to be applied on the skin and at least a pouch containing a protection for the skin zone treated with the applied substance. The protection can consist of an adhesive plaster, a bandage, a compress or a dressing. Rupture-proof devices are provided to prevent the two walls of a common pouch to be entirely separated when it is opened. Opening facilitators are provided to facilitate the opening of the different pouches. The multiple-pouch package can be produced by fixing the different single pouches one to the other or by folding on itself one strip to form the various pouches.

Abstract: An adhesive dispensing arrangement (10) comprises an adhesive patch (12), a sachet (14), a sachet sealing strip (16), a pair of parallel gauze flaps (18A and 18B), and a peelable backing strip (20). The sachet houses a medicament such as an antiseptic or anti-microbial ointment (30), and the exposable surface (32) of the sachet is formed with a series of regularly spaced apertures (34) through which the ointment (30) may be dispensed. The peeling backing strip (20) and sachet sealing strip (16) are simultaneously peeled away, thereby exposing the apertures (34), with a central portion of the sealing strip being pulled through the gap between the gauze flaps (18A and 18B). The adhesive patch (12) is then applied around the affected area, with the ointment (30) and the sachet being dispensed via the apertures onto the gauze flaps and into treating contact with the wound.

Abstract: Medical pressure-sensitive adhesive sheets having a pressure-sensitive adhesive layer on at least one side of a support so as to have an appropriate tack strength and acceptable processability. The pressure-sensitive adhesive layer is formed with a pressure-sensitive adhesive composed mainly of an acrylic polymer and a compatible component that is compatible with the acrylic polymer. The support layer contains a compatible component that is compatible with the acrylic polymer. The amount of the compatible component contained in the support layer is 70% or less of the amount of the compatible component contained in the pressure-sensitive adhesive layer and the support layer has an elongation of 200% or more without containing any compatible component.

Abstract: A wound dressing including an absorbent core defining opposed proximal and distal surfaces. A perforated skin adherent facing layer is secured to a proximal surface of the absorbent core and a liquid impervious, vapor permeable backing layer is connected to a distal surface of the absorbent core. The backing layer defines at least one compliant element disassociated from the distal surface of the absorbent core and including at least one ridge extending outwardly relative to the distal surface of the absorbent core.

Abstract: Occlusive dressing system, which comprises an endless, elongated, flexible, adhesive barrier, adapted to be arranged in a closed configuration, whereby to bound and define a surface area, and an impermeable sealing film adapted to overlie said surface area and to isolate it from the environment, when superimposed to said barrier arranged in said configuration, said barrier forming a gas-tight seal with said sealing film when the two are applied to and pressed against one another. A spreading mechanism that alows a single person to spread the sealing film over the occluding barrier and to detach the film from the main roll and ports (inlet and outlet) that can be placed across the barrier or the occluding film.

Abstract: An apparatus for drainage of a wound or surgical site of a human or animal fits anatomically, passes from inside the wound or surgical site percutaneously or covering an open wound surface and extends externally for accumulation of fluids. A plurality of fibers each with an internal end, middle and an external end is elongate with a thickness and a length wherein its thickness is substantially less than its length for flexibility. The fibers form a loose bundle with gathered external ends and with internal ends unrestrained for spreading divergently inside the wound or surgical site. A collector is positioned in fluid communication with the gathered external ends for accumulating bodily fluid guided along and amongst the fibers from the internal ends along the middle and to the external ends during drainage. Vacuum connects to draw fluid from the collector. A method has steps of providing fibers with the internal ends unrestrained, the external ends gathered in a collector to accumulate drained fluid.

Abstract: A wound therapy and tissue management system utilizes fluid differentiation. Fluid is differentiated by establishing a gradient within the system. A gradient can be established with matter or energy. Patient interfaces for establishing, maintaining and varying one or more gradients include transfer elements with first and second zones having different flow coefficients. The transfer elements exchange fluid with a patient, generally through a wound site, and with external components of the system. Osmotic solution gradients are controlled by a methodology involving the present invention for extracting solutions, which can include toxins, from patients and for introducing fluids and sumping air to wound sites.

Abstract: For application of active substances to a wound surface a porous padding (12) is provided upon the wound (10), which is sealingly covered over with a foil (14). A fluid active substance is introduced into the padding (12) via a supply line (22) and is then suctioned out of the padding (12) via a removal line (26). Closure mechanisms (32, 34) control the introduction of the active substance and the suctioning off of the active substance in the manner, that the active substance after being introduced remains for a predetermined dwell time in the padding (12), before it is suctioned off. After the suctioning off the vacuum in the padding (12) is maintained for a certain time period, before renewed introduction of the active substance. The opening of the closure mechanisms (32, 34) are temporally controlled to occur slowly.

Abstract: A delivery system for the delivery of flowable medicinal, therapeutic or medicine materials has a strip with flowable material contained and restrained therein. A removable seal is provided, so that when the removable seal is removed, the flowable material will flow from a storage area onto a site selected for treatment. The removable seal may be provided with additional features such as absorbent coatings, or additional disinfectants coatings useful in preparing the wound surface to receive the flowable wound treatment material. A preferred composition is a system, article and method for the enhancement of clotting in wounds with extravascular blood flow, especially where the surface of the tissue has been broken.

Abstract: The present invention relates to a composite material including a substrate with a first and a second surface, a boundary layer which is comprised of one or more compositions, and a topical application. The boundary layer is applied on the first surface of the substrate, and the topical application is applied to a surface of the boundary layer opposite of the substrate. Transfer efficiency of the topical application is enhanced as the transfer forces necessary to separate the topical application from the boundary layer are lower than the transfer forces necessary to separate the substrate from the boundary layer.

Abstract: An elongate rectilinear strip of skin barrier material is disclosed, such strip being of generally uniform triangular cross section through its length, such triangle having at least two, and preferably three, unequal sides. The strip may be cut to desired length and formed, stretched and/or molded by a user into a generally circular shape or into some other shape that extends about and follows the outline of a wound or stoma.

Abstract: A multi-layer wound dressing comprising at least two absorbent layers, and materials for forming absorbent layers are provided. The absorbent layers have different absorbencies, with the layer closest to the wound having a lower absorbency than the layer furthest from the wound. The wound dressing typically contains additional non-absorbing layers, such as a backing film and wound-facing film. The dressing provides absorbency of wound exudates while preventing the absorbent material from entering the wound. In specific implementations the dressing is substantially transparent prior to application to a wound, as well as after application to the wound when body fluids have been absorbed.

Abstract: A disposable eye patch includes a first sheet member, a second sheet member smaller than the first sheet member, and an adhesive layer applied to one side of the first sheet member. One portion of the adhesive layer bonds the first and second sheet members together, and another portion of the adhesive layer adheres to the tissue surrounding an eye when the eye patch is applied to a patient. A release layer may be provided to cover the exposed portion of the adhesive layer, and may be peeled off prior to the use of the eye patch. The release layer and a plurality of eye patches may be provided in the form of a dispenser roll assembly. In a method of manufacturing the disposable eye patch, the first and second sheet members may both be formed from a sheet material having an adhesive layer, and then the first and second sheet members may be adhered together with the adhesive layer on one of the sheet members contacting the adhesive layer on the other one of the sheet members.