Abstract: A fluid transfer and mixing device for use in the aseptic intermixing of a powder component with a fluid component. The device is of a simple, compact construction that includes a first adapter that can be easily connected to a container containing the powder component and a second adapter that can be removably interconnected with the first adapter and can also be readily connected to a container containing a fluid such as a diluent so as to permit aseptic intermixing of the diluent with the powder. In use a conventional needleless syringe can be easily connected to the first adapter so that the mixture of the powder and diluent can be aseptically aspirated from the first container for subsequent delivery to the patient.

Abstract: The disposable set includes an infusion device having an outflow conduit and a needle. The packager is defined by a single bag made of transparent, flexible, plastic material and having a first compartment enclosing the medicinal fluid, and a second compartment enclosing the infusion device. The two compartments are formed from two sheets of the aforementioned material, heat sealed along the outer edges of the sheets, so as to be sealed with respect to the outside environment, and the compartments are also separated in airtight manner from each other by another seal. The conduit communicates with the first compartment via a chamber formed by a further seal and acting as a drip for visually controlling the infusion treatment.

Abstract: A high-sterility and high-capacity connector for lines for outflow from bottles for containing fluid-liquid substances for medical use, comprising an elongated cylindrical body, in a lower portion of which an anatomically shaped grip portion is provided and at an upper end of which a protruding piercing element which is functionally combined with means for engaging the rim of the neck of the bottle is provided.

Abstract: A fluid transfer and mixing device for use in the aseptic intermixing of a powder component with a fluid component. The device is of a simple, compact construction that includes a first adapter that can be easily connected to a container containing the powder component and a second adapter that can be removably interconnected with the first adapter and can also be readily connected to a container containing a fluid such as a diluent so as to permit aseptic intermixing of the diluent with the powder. In use a conventional needleless syringe can be easily connected to the first adapter so that the mixture of the powder and diluent can be aseptically aspirated from the first container for subsequent delivery to the patient.

Abstract: Devices, systems and methods for treating a biological fluid are provided comprising placing the fluid in contact with a complement filter capable of depleting at least one complement fragment from the fluid while at least one component of the biological fluid is being stored.

Abstract: The invention concerns a collection bag (1) for a fluid, in particular whole blood, comprising an outer envelope (2) formed with two sheets of flexible plastic material (3, 4) assembled on their periphery so as to define an inner volume, said outer envelope (2) being provided with at least an orifice designed to enable the fluid to be supplied and dispensed, wherein at least one insert (15) is fixed in the internal volume of the bag (1) to define at least two sub-volumes (16, 17) in the internal volume, said insert (15) being arranged to form a partial obstruction to the flow of the fluid inside said internal volume leaving at least a passage for the fluid (19, 20, 22, 24) between said two sub-volumes (16, 17).

Abstract: Red blood cell sensing systems and methods rely upon straightforward measurement geometries. the systems and methods comprise an incident light source, an optical sensor, and a blood collection tube. The systems and methods hold the blood collection tube a predetermined radial distance from the incident light source where a linear relationship exists between sensed reflected light measured by the optical sensor and red blood cell hematocrit in a range of at least 10 to 90. The systems and methods make possible accurate red blood sensing without use of special optical cuvettes, mirrors, or focusing lenses. The systems and methods also make possible the use of standard transparent plastic tubing, without reliance upon special optical cuvettes.

Abstract: Methods and devices for the removal of psoralens and psoralen photoproducts from blood products are described. The methods include contacting a psoralen- and irradiation-treated blood product with a resin capable of adsorbing psoralens and psoralen photoproducts. The removal process is particularly suitable for use with platelet concentrates and plasma because the process does not have a significant adverse effect on clotting factor function. The methods and devices can be incorporated with apheresis systems and other devices and procedures currently used to process blood products for transfusion.

Abstract: A vial docking station for simultaneously sliding the spouts of a plurality of liquid medicament vials into an engaged position with matching receptacles of a like plurality of liquid reconstitution diluent bags.

Abstract: It is a primary object of the present invention to provide an automated system based on an integral fluid bag for administering a variety of intravenous drug regimens and reducing the vagaries of existing manual systems. The fluid has multiple chambers configured to implement a prescribed intravenous medical therapy. Each chamber's geometry (size, shape), sequence and position, alone and in combination with the other chambers, matches the prescribed intravenous therapy or drug regimen. The bag's configuration assures that the intravenous therapy is administered in accordance with the prescribed drug regimen, thus automating the previous manual method. A choice of fluid bag configurations may be stocked so that a prescription for well known and widely accepted drug regimens may be filled by merely selecting a bag with the appropriate chamber configuration and filling it with the prescribed medications.

Abstract: Containers and methods for storing medical solutions are provided. More specifically, containers and methods for storing components that are to be admixed, together to create a final solution, one of the components comprising a lipid. In an embodiment, a container including an interior defining at least two chambers. The first chamber includes a lipid containing liquid. The second chamber includes a liquid that does not include a lipid. The first and second chambers are separated by an openable seal.

Abstract: The invention is an improved container for collecting, freeze-drying, storing, reconstituting, and administering biological solutions and, in particular, blood products. The container features a pliable bottom wall providing intimate thermal contact with the cooling/heating shelf of the lyophilizer; a top wall incorporating a hydrophobic membrane providing a path for water vapor and a bacterial barrier; and side walls sufficiently stiff to support the ceiling but preferably also sufficiently flexible to collapse and minimize storage space especially once lyophilization is complete. The walls incorporate sealable ports that can be used to load the solution for processing and/or adding reconstituting liquids and/or administering the reconstituted solution to a patient. The top wall may incorporate a removable cover that protects the membrane before freeze-drying takes place.

Abstract: A dual-filled twin bag, a packaging including the twin bag, and a method for forming the packaged twin bags are provided. Each of two bags, a solution bag (10)and a drain bag (12) for a system used for a peritoneal dialysis procedure, are filled, at least partially, with a solution (14). A tubing set (16) connects the two filled bags (10,12) and may also be filled with solution (14) which is added to the bags (10,12) and the tubing set (16) during the manufacturing process. Alternatively, the tubing set (16) may be filled with air. The tubing set (16) is sandwiched between the solution bag (10) and the drain bag (12) and subsequently packaged in an overpouch (24). The method for forming the package including the bags filled with solution is simplified and the overall package size is reduced due to the sandwiched tubing set (16) between the solution bags (10,12) and the provision of solution in both bags (10,12).

Abstract: A containment and intravenous delivery bag device for supplying a patient with mixed chemical component nutrients includes a first pouch and a second pouch that are separated by a tube passageway. Using standard intravenous delivery bag sizes and manufacturing techniques, the tube passageway is blocked by either a clamp or a frangible valve fitted within the tube. The clamp or valve is opened, allowing fluids with the pouches to mix. The mixed liquid may then be delivered to the patient.

Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.

Abstract: The invention relates to a device and a method for separating whole blood into blood components. The device has a collecting container for collecting whole blood, a primary container, and one or a plurality of satellite containers downstream from the primary container. The collecting container is connected to the primary container via a branch line containing a leucocyte filter. In addition, a bypass line is provided between the collecting container and the primary container for creating a fluid connection that circumvents the leucocyte filter. The primary container is also connected, via an additive line, to an additive container containing an additive agent for storing a blood component. The method involves collecting the donor's whole blood in the collecting container and conveying it, via the bypass line, into the primary container. The whole blood located in the primary container is then separated by centrifuigation into an erythrocyte layer and a mixed layer of blood plasma and thrombocytes.

Abstract: One object of the present invention is to provide a medical container with multiple chambers and a production method thereof, where respective medicaments housed in a plurality of chambers can be separated without fail until performing the infusion and when performing the infusion, the respective medicaments can be easily mixed while keeping the sterile state.

Abstract: The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts—an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.

Abstract: The present invention relates to an impermeable flexible multicompartment bag for medical use for sterile solutions, and to a method for the preparation of such bags. Impermeable flexible multicompartment bags for medical use for sterile solutions for perfusions, consisting of two welded sheets of a composite material wherein the sheets forming the inner wall of the bag consist of a polypropylene and are bonded to an outer layer of a thermoplastic polymer by means of a polyolefin layer, characterized in that the sheets facing the contents of the bags which are made of a homophase copolymer of propylene are immediately welded in the intercompartment region and in the peripheral region such that the weld forming the intercompartment region can be ruptured with a force in the range of from 10 to 30 N while the weld in the peripheral region cannot be ruptured.

Abstract: A single use system and kit for producing blood platelet concentrates is described herein. In a preferred form, the kit includes a bag set in which compartments containing blood components are adjacent to separate compartments which can be inflated to express the blood components after their separation by centrifuging.

Abstract: A container for pathogen inactivating and storing blood or blood components, which includes multiple sub-compartments fluidly interconnected by an openable closure assembly. Each sub-compartment may contain a component necessary for pathogen inactivation or blood storage. Upon opening the openable closure assembly, the sub-compartments become one compartment and the components contained within each sub-compartment may be mixed together to form a combined solution for pathogen inactivation and/or storage of blood or blood components.

Abstract: The invention describes a connection system comprising at least a male connecting element and a female connecting element which can be connected to each other, as well as the male connecting element and the female connecting element. The location of contact of the two connecting elements is preferably provided with a disinfecting adhesive so that an aseptic or sterile connection can be established. Therein both connecting elements have predetermined breaking points which in the connected state are arranged one above the other so that only one breaking point within the tube is obtained via which an aseptic fluid guidance through two tubes from one sterile system to another sterile system can be carried out. Thereby a particularly simple and cost-saving connection is created which fulfills the highest sterility requirements.

Abstract: It is a primary object of the present invention to provide an automated system based on an integral fluid bag for administering a variety of intravenous drug regimens and reducing the vagaries of existing manual systems. The fluid has multiple chambers configured to implement a prescribed intravenous medical therapy. Each chamber's geometry (size, shape), sequence and position, alone and in combination with the other chambers, matches the prescribed intravenous therapy or drug regimen. The bag's configuration assures that the intravenous therapy is administered in accordance with the prescribed drug regimen, thus automating the previous manual method. A choice of fluid bag configurations may be stocked so that a prescription for well known and widely accepted drug regimens may be filled by merely selecting a bag with the appropriate chamber configuration and filling it with the prescribed medications.

Abstract: A flexible transparent container for improved storage of oxygen sensitive parenterally administerable agents comprising an inner, primary container enclosed in a substantially oxygen impermeable outer envelope with an oxygen absorber, capable of consuming essentially all residual oxygen after the outer envelope is sealed, and for sufficient period also the oxygen penetrating said envelope. The inner container is made of a polypropylene containing flexible polymeric material compatible with lipophilic agents capable of forming both permanent and peelable seals, while the envelope is made of a substantially water impermeable flexible multilayered polymeric material comprising a first outer substantially water impermeable polymeric film with oxygen barrier forming capacity, assembled with a second, inner polymeric film with a supplementary oxygen barrier forming capacity. The container essentially maintains its characteristics after being subjected to sterilization by steam or radiation.

Abstract: A neutral glucose-containing preparation with excellent stability and a near physiological pH, as a transfusion preparation with minimal glucose degradation by-products and a greatly reduced formic acid content; specifically, a glucose-containing preparation comprising separately housed first and second solutions, the first and second solutions satisfying the following conditions: (a) the first solution contains 2-50% glucose, and its pH is adjusted to 3-5 with an organic acid buffer solution; (b) the second solution contains an alkalizing agent, and has a pH value of 8-13 as a pH adjustor for the first solution; and (c) the glucose concentration is 1-15% in the preparation solution obtained by mixing the first solution and second solution, and the pH of the solution is in a range of 6-8. It is used particularly as a peritoneal perfusate, such as a perfusate for Continuous Ambulatory Peritoneal Dialysis (CAPD).

Abstract: Containers and methods for making containers are disclosed. The containers include a chamber and a pouch fixed within the chamber. During manufacture, the open edges of the pouch are sealed between the walls of the container by a seal defining, in part, the peripheral edge of the chamber.

Abstract: A blood platelet collection system includes a bucket having wells 24, 26 adapted to receive a bag system therein. The bag system includes a pair of compartmented containers. Each container includes a collection bag 12, 16 and an adjacent inflatable bag 22, 28 and is preferably an integrated structure made of three sheets 52, 54, 56. After centrifugation, the inflatable bags are caused to expand, in turn, to transfer blood components between the collection bags via tube 14.

Abstract: In this invention, injection kit is to provide. The kit is made of multiple layered flexible plastic bag formed cylindrically (soft bag), and is separated into 2˜4 compartments by one or plural welded partition easy-to-peel seal. The first compartment has a welded nozzle-like outlet of the injection solution and contains a solid medicine. The rearmost compartment (the last compartment of this kit) contains a solvent to dissolve the solid medicine. The remaining one or two mid-compartment contains a solid medicine and/or its solvent. The welded nozzle-like outlet of the first compartment is welded with a metallic injection needle, which is covered by a plastic protective cap before it is used.

Abstract: Containers and methods for storing medical solutions are provided. More specifically, containers and methods for storing components that are to be admixed together to create a final solution, one of the components comprising a lipid. In an embodiment, a container including an interior defining at least two chambers. The first chamber includes a lipid containing liquid. The second chamber includes a liquid that does not include a lipid. The first and second chambers are separated by an openable seal.

Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.

Abstract: This invention discloses a donor blood sampling apparatus attached to a tubing branch, a donor needle attached to an upstream tube, the donor needle being adapted for drawing blood from a body and a main collection bag attached to a donor tube, characterized by a flow controller.

Abstract: The invention describes a connection system comprising at least a male connecting element and a female connecting element which can be connected to each other, as well as the male connecting element and the female connecting element. The location of contact of the two connecting elements is preferably provided with a disinfecting adhesive so that an aseptic or sterile connection can be established. Therein both connecting elements have predetermined breaking points which in the connected state are arranged one above the other so that only one breaking point within the tube is obtained via which an aseptic fluid guidance through two tubes from one sterile system to another sterile system can be carried out. Thereby a particularly simple and cost-saving connection is created which fulfills the highest sterility requirements.

Abstract: Use of a solution comprising glucose for peritoneal dialysis, in which the glucose portion is sterilised separately from the remaining components at a high glucose concentration above about 20% and mixed after sterilisation, substantially according to WO 93/09820. The solution has a reduced formation of advanced glycosylation end products and the use is indicated for diabetic uremic patients.

Abstract: A bag, method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall for stress relief and to provide the constant cross-section. A peripheral flashing circumscribes the radiused edge wall and provides a suitable purchase area for sealing so that the thus formed bag is less susceptible to fracture particularly when exposed to cryogenic temperatures. The uniform thickness of the bag promulgates uniform heat transfer to and from the contents of the bag in relation to any surrounding medium at a different temperature. The bag affords more space for efficient storage and reduces heat invasion into the contents of the bag when a plurality of bags are placed, with their larger planar surfaces, in contact with each other.

Abstract: The object of the invention is a flexible plastic container for the spatially separated storage and, optionally, selective sterilization of the ingredients of preparations for parenteral or enteral use. The container comprises three compartments being suited for taking up the ingredients, namely carbohydrates within compartment 3, lipids within compartment 4, and amino acids within compartment 5 as well as connections between the compartments which can be opened sterilely from the outside. The proportions by volume of the compartments are selected such that rapid mixing of all ingredients without time-consuming pressing and kneading operations by the hospital personnel is possible within compartment 5.

Abstract: A white blood cell-removing device has a bag-shaped housing made of soft resin, a white blood cell-removing filter member partitioning the inside of the housing into an inlet side blood chamber and an outlet side blood chamber, a blood inlet port positioned at one side of the housing and communicating with the inlet side blood chamber; and a blood outlet port positioned at the other side of the housing and communicating with the outlet side blood chamber. An inner surface (the outlet side blood chamber) of the bag-shaped housing is a unevenness surface. The white blood cell-removing filter member has a filtering part and a non-filtering part formed on the entire periphery of the filtering part.

Abstract: A flexible container is provided for the storage and mixing together of diluents and medicaments. The container incorporates multiple compartments, separated by peelable seals, in which the diluents and medicaments are stored. The container is constructed of thermoplastic materials having high oxygen and moisture barrier properties which allows the container to be stored for extended periods of time without degrading the contents. The seals are ruptured by manipulation of the container to thereby mix the contents together for delivery through standard IV arrangement to a patient. The seals are constructed to provide a non-linear resistance characteristic to hydraulic pressure, which causes the seal to peel open completely along its length. The container is folded-over along the line of one of the seals and also includes a locking tab and retaining slot to secure the bag in a folded-over condition.

Abstract: A bag for an infusion solution has front and back wall portions each formed of a flexible plastic film and provided with a plurality of chambers which are filled with one infusion solution and another infusion solution or medicament, independently. The chambers are sectioned by a boundary portion having at least one weak seal portion which is closed by separably bonding inside surfaces of the plastic films mutually facing at the boundary portion so that the one infusion solution and the another infusion solution or medicament in the respective chambers are mixed together when the weak seal portion is opened. The weak seal portion is formed by applying a separable coating material, which provides a reduced bonding strength in a heat sealing process, on one or both inside surfaces of the plastic films mutually facing at the boundary portion and then effecting heat sealing process to the boundary portion. The separable coating material is applied in a form of a dot-pattern through a printing process.

Abstract: A bag for an infusion solution has front and back wall portions each formed of a flexible plastic film and provided with a plurality of chambers which are filled with one infusion solution and another infusion solution or medicament, independently. The chambers are sectioned by a boundary portion having at least one weak seal portion which is closed by separably bonding inside surfaces of the plastic films mutually facing at the boundary portion so that the one infusion solution and the another infusion solution or medicament in the respective chambers are mixed together when the weak seal portion is opened. The weak seal portion is formed by applying a separable coating material, which provides a reduced bonding strength in a heat sealing process, on one or both inside surfaces of the plastic films mutually facing at the boundary portion and then effecting heat sealing process to the boundary portion. The separable coating material is applied in a form of a dot-pattern through a printing process.

Abstract: The present invention provides a container for holding medical solutions, wherein the container comprises a fluid-tight chamber, the chamber having opposing first and second edges and opposing first and second surfaces, and a flap extending from an edge of the chamber and being hingedly connected to the chamber.

Abstract: A flexible container is provided for the storage and mixing together of diluents and medicaments. The container incorporates multiple compartments, separated by peelable seals, in which the diluents and medicaments are stored. The container is constructed of thermoplastic materials having high oxygen and moisture barrier properties which allows the container to be stored for extended periods of time without degrading the contents. The seals are ruptured by manipulation of the container to thereby mix the contents together for delivery through standard IV arrangement to a patient. The seals are constructed to provide a non-linear resistance characteristic to hydraulic pressure, which causes the seal to peel open completely along its length. The container is folded-over along the line of one of the seals and also includes a locking tab and retaining slot to secure the bag in a folded-over condition.

Abstract: A container for therapeutic use is formed of a main body, which is made of a flexible resin and provided with a bag portion. The bag portion is formed in a flat shape at at least a part thereof where mutually-opposing walls of the bag portion are peelably welded together at inner surfaces thereof to form a welded region. A hole is formed as an attachment hole through at least one of the mutually-opposing walls in the welded region. A holder with a medicament placed therein, said medicament being prone to a change in property or color upon absorption of moisture, is hermetically attached to the at least one wall over the attachment hole to seal the medicament in the holder. A moisture-barrier member with a desiccant placed therein is arranged on a side opposite to the holder so that the other wall of the bag portion is hermetically covered by the moisture-barrier member at a position at least corresponding to the attachment hole.

Abstract: The present invention relates to a storage device and method for the long-term storage of blood and, more particularly, to a blood storage device and method capable of removing oxygen from the stored blood and thereby prolonging the storage life of the deoxygenated blood.

Abstract: It is a primary object of the present invention to provide an automated system based on an integral fluid bag for administering a variety of intravenous drug regimens and reducing the vagaries of existing manual systems. The fluid has multiple chambers configured to implement a prescribed intravenous medical therapy. Each chamber's geometry (size, shape), sequence and position, alone and in combination with the other chambers, matches the prescribed intravenous therapy or drug regimen. The bag's configuration assures that the intravenous therapy is administered in accordance with the prescribed drug regimen, thus automating the previous manual method. A choice of fluid bag configurations may be stocked so that a prescription for well known and widely accepted drug regimens may be filled by merely selecting a bag with the appropriate chamber configuration and filling it with the prescribed medications.

Abstract: A intravenous infusion device which includes a bag of an impervious flexible material which is divided into two compartments by a central partition of an impervious flexible material. A first compartment is filled with an infusion liquid and contains an outlet provided with a connection to a flexible hose and an infusion needle. The second compartment is empty and has an inlet provided with a connector to an inflation device such as a hand-operated balloon. This second compartment can be inflated to exert a pressure on the first compartment in order to cause the infusion liquid to be conveyed into the patient's vein at the required rate of flow. The infusion device can be used in all cases where the bag cannot be suspended above the patient as for instance on the battlefield or after an accident. It is likewise suitable in all cases where an increased rate of infusion is required.

Abstract: A method and apparatus for the sequestration of components of a fluid by forcing heavier fractions of the fluid to pass beyond a yieldable partition integrally formed within a bag. Fluid fractions remain sequestered within bag compartments when forces driving the heavier fraction have been removed.

Abstract: A flexible container is provided for the storage and mixing together of diluents and medicaments. The container incorporates multiple compartments, separated by preferentially peelable seals, in which the diluents and medicaments are stored. The container is constructed of thermoplastic materials having high oxygen and moisture barrier properties which allows the container to be stored for extended periods of time without degrading the contents. The peelable seals are ruptured by manipulation of the container to thereby mix the contents together for delivery through standard IV arrangement to a patient. The seals are constructed such that the seal between the diluent and medicament compartments is preferentially ruptured such that a liquid medicament and a diluent are always mixed before the combined solution is accessible for administration. The container is fillable with a single component liquid medicament which may be susceptible to sloshing or turbulence.

Abstract: An apparatus is provided for autologous sequestration of blood from a patient prior to, during and after surgery. Sequestered blood contained in an assembly of oxygenated blood collection bags is kept in fluid contact with the patient throughout surgery, thereby assuring continuity with the patient's circulatory system. The plurality of blood collection bags is interconnected with a corresponding plurality of valves which is interconnected with a plurality of flexible tubes which is attached to a patient's right atrium or a peripheral artery. Following induction of anesthesia in the operating room, a patient's blood is sequestered into a collection bag assembly which forms a closed circuit blood reservoir system. Collected blood during surgery trickles back into the patient's blood system, thereby emulating venous blood flow. The collection bags are agitated and oxygenated to promote the functionality and longevity of the platelets in the sequestered blood.

Abstract: It is a primary object of the present invention to provide an automated system based on an integral fluid bag for administering a variety of intravenous drug regimens and reducing the vagaries of existing manual systems. The fluid has multiple chambers configured to implement a prescribed intravenous medical therapy. Each chamber's geometry (size, shape), sequence and position, alone and in combination with the other chambers, matches the prescribed intravenous therapy or drug regimen. The bag's configuration assures that the intravenous therapy is administered in accordance with the prescribed drug regimen, thus automating the previous manual method. A choice of fluid bag configurations may be stocked so that a prescription for well known and widely accepted drug regimens may be filled by merely selecting a bag with the appropriate chamber configuration and filling it with the prescribed medications.

Abstract: A containment and intravenous delivery bag device for supplying a patient with mixed chemical component nutrients includes a first pouch and a second pouch that are separated by a tube passageway. A frangible valve is fitted within the tube. When the frangible valve is broken a first liquid within the first pouch enters the second pouch and mixes with a second liquid within the second pouch. The mixed liquid may then be delivered to the patient.