Abstract: Provided are methods for preparing pathogen-inactivated platelet compositions, as well as processing sets and compositions related thereto.

Abstract: A cap assembly for a refill capsule and associated refill system is disclosed. The cap assembly (200) comprises an inner wall (202) defining a conduit (203) through the cap assembly (200) and an outer wall (204) surrounding the inner wall to form a circumferential void between the inner and outer walls (202, 204). A connecting wall joins the inner and outer walls (202, 204). The cap assembly (200) further comprises a closure member (208) which is sealed to the inner wall (202) with a peripheral frangible connection (210). The frangible connection (210) is disposed between radially offset portions of the inner wall (202).

Abstract: A tray for positioning, in a fixed positional relationship, a medical vial 7 together with a vial adapter 4 is disclosed. A tray member 10 includes a vial accommodation cavity 11 and a vial adapter accommodation cavity 12, each comprises retaining members 19, 37a, 37b, 35a, 35b, 36a, 36b configured to position the vial adapter 4 and the vial 7 spaced apart from each other and in axial alignment in an intermediate position. The retaining members 19, 37a, 37b, 35a, 35b, 36a, 36b are further configured to guide a relative axial movement of the vial 7 and vial adapter 4 from the intermediate position to a transfer position while maintaining the axial alignment of the vial 7 with the vial adapter 4. In the transfer position the vial adapter 4 is locked to the vial 7 and a piercing mandrel 57 pierces a vial stopper 76 for liquid transfer.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to dispensers. In some embodiments, a dispenser comprises a main body including an outer wall and an inner wall, the inner wall defining an aperture through the main body; a first seal, wherein the first seal is affixed to the main body and encloses a lower portion of the aperture; a button seated within the aperture and configured to be manipulable between a first position and a second position; a container housed within the button and configured to store a material, wherein when the button is in the second position the container contacts the first seal to allow the material to exit the dispenser; and a second seal, wherein the second seal is affixed to an upper surface of the main body and encloses an upper portion of the aperture.

Abstract: A method of anesthetizing a tympanic membrane of an ear of a patient using iontophoresis is disclosed. The method involves delivering an anesthetizing drug solution to an ear canal of the patient's ear, wherein the drug solution includes an anesthetic and a buffer, and wherein the drug solution has a pH in a range of about 6.5 to about 7.5; and applying an amount of current to the drug solution, wherein the applied amount of current is increased at a rate of less than about 0.5 milliamp per second until a maximum current is achieved.

Abstract: The present disclosure relates to a connector for connecting a medical injection device to a container closed by a septum. The connector has a distal tip and a sleeve extending around the tip. The sleeve has an inner threaded portion. The connector includes a proximal part configured to engage the tip of the injection device. The proximal part includes an outer threaded portion configured to be removably screwed to the inner threaded portion of the sleeve, distal part configured to be connected to the container, and a hollow spike extending from the proximal part. The hollow spike has an internal volume in fluidic connection with the injection device and perforates the septum of the container when the distal part is connected to the container. The spike includes an opening in a distal end being configured to create a connection between the medical injection device and the container.

Abstract: A plug for use in a cap assembly of a refill capsule is disclosed. The plug (300) generally comprises a hollow tubular body (302) with an open proximal end that is surrounded by a first rim (304) that provides a proximal abutment surface for bearing against a frangible sealing component of a cap assembly. A tubular skirt wall (306) is arranged coaxially with respect to the tubular body, and extends around the skirt wall (306) to form a plug recess (308) between the skirt wall (306) and the tubular body (302). The skirt wall (306) extends from a skirt distal end at which the skirt wall (306) is connected to the tubular body (302), to a free proximal end. The free proximal end of the skirt comprises an outwardly extending flange (310) comprising a distal facing abutment surface (312) for abutting a rim (406) of a refillable vessel (400).

Abstract: The present disclosure relates to an aqueous composition stored in a single unit dosage container, where the aqueous composition consists of glucose, sodium bicarbonate, water, and a pH adjusting agent if needed to adjust the pH, wherein the pH of the composition is from 6.7 to 8.1. Such composition is stable for at least 3 months at room temperature conditions.

Abstract: The invention relates to a multiple-chamber container (1, 1*) for storing and mixing a multi-component liquid coating or adhesive system (M), comprising a first chamber (10) for a first mixing component (B) and at least one other chamber (20) for another mixing component (H), the first chamber (10) and the at least one other chamber (20) being separated by at least one separating wall (30) in liquid-tight fashion and the separating wall (30) comprising a pierceable separating layer (40). The multiple-chamber container further comprises at least one piercing element (50) for piercing the pierceable separating layer (40) in such a way that the first and the one other mixing component (B, H) mix in the first or the at least one other chamber (10, 20). The multiple-chamber container (1, 1*) is characterized in that the at least one other chamber (20) is coaxial to the first chamber (10), the separating layer (40) being partially formed in the separating wall (30).

Abstract: A method and system for buoyant separation of a target constituent of a sample, the method comprising: at a process chamber, combining a volume of substrates having a first density with the sample, thereby producing a population of target-bound complexes comprising the target constituent bound to at least a portion of the volume of substrates; within the process chamber, physically separating the population of target-bound complexes from the sample based upon interaction between the volume of substrates and an applied force; aggregating the population of target-bound complexes at a collection region of the process chamber; extracting the population of target-bound complexes from the process chamber; and processing the target constituent from the population of target-bound complexes for further analysis.

Abstract: A concentrate container that is coupled to a drinking container having an output for discharging a drink is proposed. The concentrate container has a chamber in which a concentrate is kept, an outlet through which a concentrate is put into the drinking container, and a container mouth for discharging a liquid mixture of the concentrate and a drink to the outside when the drinking container and the concentrate container are combined. The inner diameter of the concentrate container outlet is determined to be fitted on the drinking container outlet, a thread is formed inside the concentrate container outlet, and the thread is engaged with a thread of the drinking container outlet.

Abstract: A syringe-based device includes a housing and an actuator mechanism including a first member and a second member. The first member includes a syringe body and a plunger, the plunger being movably disposed within the syringe body. The second member includes a second member plunger seal and a valve operably and selectively coupled to the second member plunger seal such that the valve is positioned proximal of the second member plunger seal. The device also includes a first fluid reservoir and a second fluid reservoir. The device transitions from a first configuration to a second configuration in which the first type of fluid is expelled from the first fluid reservoir, to a third configuration in which the second type of fluid is expelled from the second fluid reservoir through the valve.

Abstract: In some embodiments, a reconstitution or medicinal fluid delivery device includes a transfer engine including two fluidly connected spikes, each configured to pierce a container. A check valve may be disposed between the two spikes to allow unidirectional flow from one container to the other. Physical access to a fluid outlet may be obstructed by a housing until the reconstitution or medicinal fluid delivery device is actuated, whereupon physical access to the fluid outlet is permitted. The reconstitution or medicinal fluid delivery device may be placed on a flat surface and actuated with force applied in a single direction toward the flat surface.

Abstract: A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

Abstract: The present disclosure provides systems and methods for refilling fluid containers. A fluid container may include a bottle and a valve assembly. The valve assembly may include two valves and be configured to engage with the bottle and a filling head or dispensing head. A system is configured to provide pressurized fluid to the refillable container, monitor filling, determine when to stop filling, and determine how much fluid was provided. The valve assembly may include a float mechanism coupled to one of the valves of the valve assembly to ensure fluid flow is stopped when the fluid container is full. The fluid, which can include carbon dioxide, is stored in a storage tank. A flow system provides the fluid to a filling head, which engages with the fluid container. The flow system includes a transfer pump, valves, and sensors configured to provide the fluid to the filling head.

Abstract: A cellular medicine transfer system includes: an adapter for a cellular medicine container including a first flow channel and a second flow channel through each of which a liquid and cells can flow; a cellular medicine container to which the adapter is attached, and in which a cellular medicine to be transferred is stored; an administration medium storage container that communicates with the first flow channel, and in which an administration medium is stored; a collection container for collecting a cellular medicine, that communicates with the second flow channel of the adapter; and a powering device that imparts motive power for transferring the administration medium from the administration medium storage container through the first flow channel to the cellular medicine container, and for transferring the cellular medicine and the administration medium from the cellular medicine container through the second flow channel to the collection container.

Abstract: The present disclosure includes devices, apparatuses, kits, and methods for replacing a nucleus pulposus of an intervertebral disc with an implantable nuclear prosthesis filled with a curable silicone material in situ. Configurations of the present spinal implant devices include a flexible body defining an outer fillable enclosure that defines an outer chamber, an inner fillable enclosure that defines an inner chamber, and a proximal plug configured to be coupled to the inner fillable enclosure.

Abstract: A device is provided for pooling a fluid from a container unit having at least one container, and includes an inlet port having at least one inlet channel configured for receiving the fluid or ambient air, and an outlet port having at least one outlet channel configured for delivering the fluid to an attachment. Both inlet and outlet ports are disposed on the device. A cavity is provided for accommodating insertion of the container unit for pooling the fluid from the at least one container. At least one spike is disposed in the cavity and configured for puncturing a stopper of the at least one container when the container unit transitions from an upper position to a lower position.

Abstract: A device for separating and concentrating target particles or molecules from a fibrinogen containing sample of liquid comprises a container (1) for collecting the sample and a closure (2). The container (1) comprises a first end and a second end and at least one interior wall defining a reservoir portion (5) for receiving the sample. The reservoir portion (5) comprises at least one anchor element (4) to locally catch a polymerized fibrin pellet formed upon the addition of the sample into the container. The separation and concentration process is operated by trapping the target particles or molecules into the so-formed polymerized fibrin pellet that are captured on the anchor element (4).

Abstract: The present disclosure provides a flexible container (10). In an embodiment, the flexible container includes: a front panel (22), a rear panel (24), a first gusseted side panel (18), and a second gusseted side panel (20). The gusseted side panels adjoin the front panel and the rear panel along peripheral seals (41) to form (i) a top portion, (ii) a body portion, and (iii) a bottom portion. The top portion comprises a neck (27) and a fitment (30) in the neck. The top portion comprises a top handle (12) extending above the fitment, the top handle having a reciprocal attachment member (5). The bottom portion comprises a bottom handle (14) and a tether (6) extending from the bottom handle. A distal end of the tether has an attachment member (7), the attachment member adapted to secure to the reciprocal attachment member.

Abstract: The invention relates to a concentrated product storage cartridge for a diluting and dispensing container, comprising an external body, with an open lower end having a closing edge on the lower end thereof; and on the opposite end, there are flaps extending above the cylindrical tube of the external body, comprising a quick-coupling means; an opening for accessing the inner region thereof, where is placed an internal plunger, forming a filling region; and, on the upper end thereof, having quick-coupling means to be attached to the cover of cartridge. Said cover comprises upper ring flaps, arranged in order to interlock with the quick-coupling means of the internal plunger, forming a single assembly with an opening that can engage with the flaps of the external body, which are mounted in a way to provide displacement mobility in both directions downwards and upwards in relation to the internal plunger head.

Abstract: A compounder system having a vial puck configured for attachment to a vial containing a drug is provided. The vial puck includes features for facilitating uniform control of vials of various sizes in an automatic compounder system. The vial puck features may include a vial recess for receiving a vial of a particular size and securing the vial within the vial recess. The features may also include a cylindrical central portion, perpendicular extensions that extend from a top of the cylindrical central portion, a gear extending from the cylindrical central portion, and a sealing member disposed in the cylindrical central portion. The vial puck may include a cylindrical protrusion configured to press against a septum of the vial to form a seal between the vial puck and the vial. The sealing member may be configured to receive a needle of the compounder system therethrough to allow access to the vial.

Abstract: An apparatus includes a transfer adapter, a puncture member, a disinfection member, and a fluid reservoir. The transfer adapter has a proximal end portion and a distal end portion, and defines an inner volume configured to receive the puncture member. The transfer adapter is coupled to the disinfection member. The distal end portion of the transfer adapter includes a port fluidically coupled to the puncture member and configured to be placed in fluid communication with a bodily-fluid of a patient. The proximal end portion is configured to receive a portion of the fluid reservoir to allow the fluid reservoir to be moved within the inner volume between a first position, in which a surface of the fluid reservoir is placed in contact with the disinfection member, and a second position, in which the puncture member punctures the surface to place the puncture member in fluid communication with the fluid reservoir.

Abstract: A system for facilitating instrument delivery through a peripheral intravenous catheter may include a catheter adapter having a proximal end, a distal end, and a lumen extending there through. The catheter adapter may include a side port. The system may include an extension tube extending from the side port. The system may include a blood control valve disposed in the lumen of the catheter adapter. The system may include a peripheral intravenous catheter extending distally from the catheter adapter.

Abstract: The Improved Salad Dressing Preparation and Storage Container is a food preparation device that allows for conveniently measuring, mixing, and dispensing of homemade vinaigrette salad dressing. The device uses two adjacent, adjoined compartments that are volumetrically proportioned to allow for the recommended ratio of oil and vinegar (acid) to be consistently achieved by filling them with oil and vinegar to the same apparent level. The Improved Salad Dressing Preparation and Storage Container may also be configured for commercial sale pre-filled with the oil and vinegar contents, those kept separated by sealing the adjoined compartments using an adapted seal. The pre-filled container may be designed and marketed for secondary use by consumers for use in making their own vinaigrette salad dressing recipes.

Abstract: A closure device for use with a container having a container neck comprises a cap member having a first fluid chamber and a housing having a second fluid chamber. The housing is arranged to move relative to the cap member between a first armed position and a second firing position. The housing includes a first plug member adapted to close a bottom aperture in the first fluid chamber in the first armed position. The cap member includes a second plug member adapted to close a bottom aperture in the second fluid chamber in the first armed position. In the second firing position the first plug member is removed from the aperture in the first fluid chamber and the second plug member is removed from the aperture in the second fluid chamber.

Abstract: In combination a spouted pouch to be filled with a flowable product by a filling machine, a plug, and a cap. The interference fit plug is releasably mounted over the top end of the neck of the spout body and hermetically seals the product passage of the spout body. The plug is adapted to be removed by the filling machine and to be replaced by pressing the plug onto the neck after filling of the pouch. The plug removal, filling, and replacing of the plug are preferably performed in an aseptic environment. The cap is after the filling of the pouch and the replacing of the plug onto the neck. The capping is preferably performed by a capping machine in a non-aseptic environment.

Abstract: The present invention relates to a sealing device to seal a container, the sealing device including: a tip that defines an internal passage leading to an opening and is designed to allow connection to a collection member such as an enteral syringe, a non-return valve that is associated with the tip and is designed to open during collection of the contents of the container using the collection member, at least one air-return port, and an antibacterial filter associated with said at least one port.

Abstract: A mixing syringe including a valve mechanism is configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for mixing of the one or more substances, and a resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject.

Abstract: The invention relates to syringes for storing and mixing components.

Abstract: Described is an automated reagent mixing container for separately storing and automatically mixing together at least two stored reagent components.

Abstract: A unit dose container for the containment of an intranasal formulation for use with the POD device.

Abstract: A process for the production of a device for dispensing eye drops. The process includes the steps of providing a first container and a second container configured to be engaged in a fluid-tight manner, providing a spacer, introducing a water-based solution inside the first container, introducing a solution or dispersion comprising a drug inside the second container, arranging the spacer between the first and second containers, engaging in a fluid-tight manner the second container and the first container, and freeze-drying the solution or dispersion comprising the drug.

Abstract: Provided herein are systems for preparing and delivering fibrin sealant to a surface and methods of use thereof. In one embodiment, the system comprises: a. a quantity of a liquid mixture disposed within a container, the mixture comprising: I. fibrin or II. fibrinogen and Factor II; and b. a resin bed disposed within a vessel, the vessel capable of being in fluid communication with the container, wherein when in fluid communication, passage of the mixture through the vessel results in modification of the concentration of small molecules inhibitor(s) and/or inducer(s) within the mixture, favoring fibrin clot formation.

Abstract: A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a valve between a first and second chamber that are slidably movable relative to each other and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

Abstract: Embodiments of the present invention relate to a filtration device and method for filtering liquids. In conventional devices, a liquid is placed in a vial, and a plunger, having a filter membrane located at one end, is depressed into the vial, causing the liquid to pass through the filter membrane into the interior of the plunger, where it is stored until required for further processing. However, such plungers are typically made of a plastics material. It is undesirable to store the filtered liquid in contact with plastics for extended periods of time, as contaminants may leach from the plastics material into the sample. In embodiments of the present invention, a filtrate receptacle made from a different material to the plunger, such as a glass material, is located in the interior of the plunger and the filtered liquid collected in the filtrate receptacle after passing through the filter membrane.

Abstract: Disclosed are a closure system for an applicator attachment on a container for pharmaceutical preparations and to a use of the closure system, a syringe for medical purposes, including a container for pharmaceutical preparations and a closure system, and a method of assembling a syringe. The aforementioned operate such that splash prevention and a venting function are integrated in the closure system.

Abstract: Liquid container with a predetermined break point (4), which is covered by an elastomer septum (3). The container forms a hollow body (10) made of a single material that is compatible with critical liquids such as medicines. The elastomer septum (3) and the predetermined break point (4) can be pierced by a hollow needle (51) in order to withdraw liquid from the container.

Abstract: The invention provides sublingual formulations containing buprenorphine, a pharmaceutically acceptable salt thereof, or a derivative thereof. The invention further provides sublingual formulations containing buprenorphine and naloxone, pharmaceutically acceptable salts thereof or derivatives thereof. The invention further provides a method of treating pain or opioid dependence by administering sublingual formulations containing buprenorphine, a pharmaceutically acceptable salt thereof, or a derivative thereof to a patient in need thereof.

Abstract: A coupling component is disclosed for transmitting medical substances, comprising two channels for conveyance of medical substances in two substantially opposite directions and a means for releasable connection to a second coupling component having a further channel for creating a coupling. The connecting means is a thread. A method for conveying medical substances to and from a container is also disclosed.

Abstract: A withdrawal spike unit (200) comprises a withdrawal spike component (30?) and an integrally formed adapter component (60?) that is adapted to couple with a vial (10) in a safe and secure manner. The integral formation of the component parts (30?, 60?) makes fully automated manufacture and assembly of assemblies comprising such a withdrawal spike unit (200) coupled to a vial (10) possible. As such, human errors associated with the assembly at the point of use are mitigated.

Abstract: An apparatus comprises a plunger able to fit in a cartridge or syringe. The plunger includes an outer portion and a deflection portion. The outer portion is able to engage the body of the cartridge or syringe. The outer portion is operable to apply a first radial force to the cartridge or syringe. The deflection portion is positioned within the outer portion and is movable between a locked position and an unlocked position. The deflection portion in the unlocked position causes the outer portion to apply a second radial force to the cartridge or syringe.

Abstract: The present invention refers to a flexible multiple chamber bag comprising: a) three adjacent chambers, a first chamber partially separating a second upper chamber from a third lower chamber by first and second welded seams, b) said second chamber and said third chamber being partially connected by a third welded seam, c) said first welded seam being non-peelable and said second and third welded seams being peelable said second and third welded seams having the shape of an inverse letter “V” each second and third welded seam starting at the basic point of said “V” and terminating essentially in a right angle at the circumference weld of said bag, said bag comprising a hanger flap extending from the top end of said bag and a medical port welded to the lower end of said circumferential weld.

Abstract: Delivering a blood processing solution to blood in a blood bag includes coupling a first tube to a vented spike at one end and to a Y-shaped tube connector at a second end. An in-line microbiotic barrier filter is coupled to the first tube between its ends. A second tube is coupled to a transfer bag at one end and to the Y-shaped tube connector at its other end. A third tube is coupled to the output of the Y-shaped tube connector and sealed at its distal end. The blood bag includes a fourth tube that is sealed at a distal end. The third tube is welded to the fourth tube using a sterile tubing welder, wherein a functionally-closed, sterile flow path through which the blood processing solution can flow into the blood bag is maintained.

Abstract: A connector for providing sterile access to a flexible container is provided that comprises a tubular member having a first portion and a second portion, each of the first portion and the second portion having an open end. The first portion and second portion are joined to each other by a frangible segment, with each of the first portion and the second portion having a gripable surface associated therewith that is configured to facilitate the application of torsional force to the tubular member at the frangible segment. Upon the application of a sufficient amount of torsional force, the frangible segment will break, permitting the first and second portions to be separated from each other.

Abstract: The invention relates to a drip chamber for an infusion device and an infusion device having such a drip chamber, by means of which medical solutions can be fed to a patient, such as infusion solutions for chemotherapy. The drip chamber (1) according to the invention is provided for connecting to a fastener (8) of an infusion container (2), comprising a withdrawal part (25) for withdrawing fluid, having an opening (28) closed by a penetrable membrane (27) and an injection part (26) for injecting a fluid, having an opening (30) closed by a penetrable membrane (29). The connecting part (7) and/or piercing spike (11) of the drip chamber (1) according to the invention is designed such that a snap-fit or latching connection to the injection part (13) and/or the withdrawing part (25) of the fastener (8) of the infusion container (2) can be produced when the connecting part (7) of the drip chamber (1) is connected to the fastener (8) of the infusion container (2).

Abstract: Some embodiments disclosed herein related to a device for transferring precise amounts of fluid from at least one source container to a at least one target container. In some embodiments, the fluid is first transferred from the source container (e.g., a vial) through a connector to an intermediate measuring container (e.g., a syringe). In some embodiments air can pass through an air inlet and enter the vial to compensate for the volume of fluid withdrawn from the vial. An air check valve or a bag or a filter can prevent the fluid from escaping through the air inlet. The precisely measured amount of fluid can then be transferred from the intermediate measuring container to the target container (e.g., an IV bag). In some embodiments the connector can include a source check valve and a target check valve to direct fluid first from the source container to the intermediate measuring container and then from the intermediate measuring container to the target container.

Abstract: The present invention proposes a dispensing container (1) A for probiotics (2) in a viscous or liquid carrier (3), the probiotics (2) having a higher specific weight than the viscous or liquid carrier (3), wherein the container (1) comprises a reservoir (4) for holding the carrier (3) and a dispensing head (5) being in fluid connection with the reservoir (4), the dispensing head (5) comprising at least one outlet (6), wherein the concentration of the probiotics (2) decreases from the outlet (6) of the dispensing head (5) towards a bottom portion (1a) of the reservoir (1).

Abstract: The present invention concerns a male connection part for connection with a female piercing member protection device having a longitudinal cylinder-like body having a longitudinal axis C, a first side and a second side, an outer and an inner surface, a barrier member arranged at the center of the first side of the male connection member, intersecting the longitudinal axis C, and a fluid communication channel extending from the barrier member of the male connection part to the second side of the male connection part, wherein the male connection part further comprises at least one turning grip protrusion to provide for an increased turning friction between the female piercing member protection device after assembly.

Abstract: A dispensing assembly includes a syringe body having a barrel and a dispensing tip. The dispensing assembly further includes a mixing and plunging assembly configured for coupling with the syringe body and comprising a mixer and a plunger. The mixer is configured for mixing material in the barrel and has a rod and a mixing element removably connected with the rod. The plunger is configured to dispense material from the barrel through the dispensing tip. Also, the rod is configured to be detached from the mixing element and used to push material out of the dispensing tip.