Therapeutic Material Introduced By Subcutaneous Implant (e.g., Peritoneal Injectors) Patents (Class 604/502)
  • Patent number: 10123969
    Abstract: A method of enhancing therapeutic/drug transport to the perivascular space of the brain of a patient is disclosed. In one embodiment, the method comprises the step of introducing a therapeutic/drug and an osmolyte of the present invention into a patient's cerebrospinal fluid (CSF), wherein the osmolyte is introduced to the CSF at a concentration of between 0.5 and 12.9 M (dependent on the solubility upper limit of the osmolyte), and wherein the therapeutic/drug delivery to the perivascular spaces of cerebral blood vessels and parenchyma of the central nervous system is facilitated by the presence of the osmolyte.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: November 13, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert G. Thorne, Michelle E. Pizzo, Daniel J. Wolak
  • Patent number: 10010667
    Abstract: Techniques are disclosed for reducing the accumulation of gases in an implantable infusion device. In one example, an implantable infusion device (IID) includes a housing, an expandable and contractible reservoir, and a standoff member. The expandable and contractible reservoir is configured to store a therapeutic agent and is arranged within the housing. A first end of the reservoir is configured to collapse toward a second end of the reservoir as the reservoir contracts. The standoff member is interposed between the first end and the second end of the reservoir and is configured to hold at least a portion of the first end offset from the second end when the reservoir is in a contracted state.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: July 3, 2018
    Assignee: Medtronic, Inc.
    Inventors: James M. Haase, Ronald L. Mezera, John M. Gray, Nicholas R. Whitehead
  • Patent number: 10006841
    Abstract: Trapping devices and methods are provided for capturing a medical analyte, in blood or another biological fluid. The device may include a structural substrate and a binding agent, such as an antibody, affixed to the structural substrate, wherein the binding agent is capable of binding or attaching with a medical analyte, such as a viral particle, and the device is configured for placement in a biological cavity or vessel (containing a biological fluid) in a patient. The trapping device, which may be in a twisted coil shape, is configured to trap at least some of the medical analyte, such a viral particle, present in the biological fluid. The method may include deploying a trapping device into the patient's blood vessel; after a period following the deployment, removing the trapping device from the biological cavity or blood vessel; and then analyzing the trapping device for the presence of the medical analyte.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: June 26, 2018
    Assignees: Massachusetts Institute of Technology, Lahey Clinic Foundation, Inc.
    Inventors: Michael J. Cima, Gregory J. Ekchian, Christophoros C. Vassiliou, Vincent H. Liu, Christoph Wald, Sebastian Flacke, Fredric D. Gordon
  • Patent number: 9987195
    Abstract: In certain embodiments, a vial adaptor comprises a housing member, a connector configured to couple the adaptor with a vial, a regulator channel, and an extractor channel formed in the housing member. The extractor channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate flow of a regulating fluid to compensate for changes in volume of a medical fluid in the vial. In some embodiments, an expansion member is disposed on the housing member and is configured to expand and contract in accordance with changes in the volume of a medical fluid in the vial.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: June 5, 2018
    Assignee: ICU Medical, Inc.
    Inventor: Thomas F. Fangrow
  • Patent number: 9724214
    Abstract: Devices, systems, and methods for providing retroperfusion to at least one ischemic tissue in a minimally invasive manner are disclosed. At least some of the embodiments disclosed herein enable an anastomosis to be formed between a vein and an artery without the use of sutures and through a non-invasive procedure. In addition, various disclosed embodiments provide a cannula device comprising a Y-configuration for bifurcating arterial flow between an anastomosis and the underlying artery. The devices, systems and methods herein can further provide simultaneous autoretroperfusion therapy to more than one area of an ischemic tissue.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: August 8, 2017
    Assignee: CVDevices, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 9572976
    Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The electrode array is maintained on the spinal cord by way of a spring or support structure that is anchored to an anatomical structure outside the spinal cord but near the site of implantation. Suitable anchoring structures include the vertebrae and the dura. Secured in this fashion, the support structure maintains a gentle pressure of the electrode array against the spinal cord so as to stay in electrical contact but minimize injury or inflammation. The device may accommodate and buffer movement of the spinal cord both laterally and in a caudal-rostral fashion so that the electrode array remains in place.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: February 21, 2017
    Assignee: University of Iowa Research Foundation
    Inventors: Matthew A. Howard, Hiroyuki Oya, Steve Viljoen, Chandan G. Reddy
  • Patent number: 9491966
    Abstract: The present invention is directed to polyphenolic polymers formed from dihydroxybenzoic acid (DHB) derivatives or from resorcinol derivatives, monomers which form such polymers, blends of the polymers with drugs and/or additional polymers, as well as medical devices formed from, coated with, impregnated by or coverings made with any of the foregoing polymers (with or without drugs) or blends (with or without drugs).
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: November 15, 2016
    Assignee: TYRX, Inc.
    Inventors: Arikha Moses, Satish Pulapura, Qing Ge, Sarita Nethula, Archana Rajaram
  • Patent number: 9402997
    Abstract: A peripheral nerve conduction diagnosis system that utilizes an electrostimulation device having dry elastomer electrodes and a distance measuring device that allow a user to move the electrostimulation device along the skin of a patient while in constant contact with the skin and measure the distance moved.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 2, 2016
    Inventor: Tomasz Andrzej Kosierkiewicz
  • Patent number: 9403008
    Abstract: This invention provides a new technology for management of back pain by stimulating the spinal cord in a manner that renders it refractory to transmission of deleterious or undesirable sensory input. The electrical stimulus comprises high frequency pulses in a regular or complex pattern or that are stochastically produced under microprocessor control. The stimulus is applied directly to the surface of the spinal cord from within the spinal canal, which provides important benefits over previous technology. The stimulus alleviates symptoms and signs of back pain, while minimizing the risk of side effects such as paresthesia, and potentially minimizing the effects on motor neuron transmission and proprioception.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: August 2, 2016
    Assignee: University of Iowa Research Foundation
    Inventor: Matthew A. Howard
  • Patent number: 9259530
    Abstract: An implantable infusion device includes a positive pressure reservoir, a pump, a flow restrictor, and an outlet. The device includes a first fluid flow path from the reservoir to the outlet, where the pump is downstream of the reservoir, and the outlet is downstream of the pump. The device further includes a second fluid flow path from the reservoir to the outlet, where the flow restrictor is downstream of the reservoir, and the outlet is downstream of the restrictor. The device may also include one or more controllable, MRI-safe valves to select whether fluid is delivered via the first or second flow path.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: February 16, 2016
    Assignee: Medtronic, Inc.
    Inventor: Steven R. Christenson
  • Patent number: 9254379
    Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The electrode array is maintained on the spinal cord by way of a spring or support structure that is anchored to an anatomical structure outside the spinal cord but near the site of implantation. Suitable anchoring structures include the vertebrae and the dura. Secured in this fashion, the support structure maintains a gentle pressure of the electrode array against the spinal cord so as to stay in electrical contact but minimize injury or inflammation. The device may accommodate and buffer movement of the spinal cord both laterally and in a caudal-rostral fashion so that the electrode array remains in place.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: February 9, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Matthew A. Howard, Hiroyuki Oya, Steve Viljoen, Chandan G. Reddy
  • Patent number: 9205242
    Abstract: A septum for a port is provided, the septum having a top wall and a side wall. The side wall can include a pressure-activated valve element for regulating the flow of fluid across the valve. The curvature of the side wall and the geometry of the sidewall and the housing can be tailored to bias the valve element to open at different pressures during infusion and aspiration. The side wall can also include an extended portion that can function as a suture wing for securing the port within a port pocket.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: December 8, 2015
    Assignee: AngioDynamics, Inc.
    Inventors: Marcia Nardone, Damon Casiello
  • Patent number: 9022973
    Abstract: In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: May 5, 2015
    Assignee: New World Pharmaceuticals, LLC
    Inventors: Frederick A. Sexton, Ian Ivar Suni, Cetin Cetinkaya, Stephanie Schuckers, Eduard Sazonov
  • Publication number: 20150073381
    Abstract: The invention provides multi-chamber encapsulated cell therapy cartridge devices that are capable of delivering biologically active molecules as well as methods of using these devices.
    Type: Application
    Filed: September 10, 2014
    Publication date: March 12, 2015
    Inventors: Konrad A. Kauper, John Fraser Mills, Megan Billings, Michael R. Rivera, Alline Monteiro Alcantara Lelis
  • Patent number: 8972003
    Abstract: The perivascular leak repair system, and method of using the same, of the present invention provides a sealant reservoir 102 with a repair catheter 104 operably attached; a flow control device 106 disposed between the sealant reservoir 102 and the repair catheter 104, and the flow control device 106 responsive to a flow control signal 108; a heart phase detector 114 generating a diastole phase signal 112; an injection switch 122 generating a injection signal 120; and a flow controller 110 responsive to the diastole phase signal 112 and the injection signal 120, and generating the flow control signal 108. A method of sealing a perivascular leak comprises identifying the perivascular leak 140; inserting a repair catheter to the perivascular leak 142; injecting sealant at the perivascular leak 144; and removing the repair catheter 146. The sealant can be injected when the heart is in diastole to sweep the sealant into the perivascular leak.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: March 3, 2015
    Assignee: Medtronic Vascular, Inc.
    Inventors: Jeffrey W. Allen, David S. Brin, Chris M. Coppin
  • Patent number: 8954142
    Abstract: A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: February 10, 2015
    Assignee: Nauronano AB
    Inventors: Fredrik Ek, Nils Danielsen, Jenny Eriksson Linsmeier, Per Petersson, Jens Schouenborg
  • Patent number: 8924023
    Abstract: A method for evaluating dosing from an implanted infusion system that includes receiving input regarding the identity of a therapeutic agent into an external device. The method further includes displaying on the external device a predetermined set of symptoms associated with the therapeutic agent; receiving input into the external device regarding with which of the symptoms the patient presents; and determining whether the therapeutic agent is being delivered, or has been delivered, at an appropriate dose based on the input identity of the therapeutic agent and the input symptoms.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: December 30, 2014
    Assignee: Medtronic, Inc.
    Inventor: Emem Akpan
  • Publication number: 20140364463
    Abstract: The present invention relates to methods of treating and/or ameliorating the severity of inflammation and autoimmunity in the central nervous system (CNS). In one embodiment, the present invention provides a method of treating multiple sclerosis by administering a therapeutically effective dosage of nicotine, or a pharmaceutical equivalent, analog, derivative, or salt thereof.
    Type: Application
    Filed: August 4, 2014
    Publication date: December 11, 2014
    Applicant: DIGNITY HEALTH
    Inventors: Fu-Dong Shi, Ronald J. Lukas, Timothy Vollmer
  • Patent number: 8888745
    Abstract: The invention pertains to an applicator (1) for inserting an implant, in particular a rod-like implant (2) containing an active substance, under the skin of a human or animal, comprising a housing (3), a cannula (6) extending from the housing (3), and a handle (15) for grasping and maneuvering the applicator (1) and the cannula (6) during insertion of an implant (2). In accordance with the invention, the handle (15) extends above at least part of the length of the cannula (6). Such a handle facilitates insertion of the cannula and/or accurate positioning of the implant.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: November 18, 2014
    Assignee: Merck Sharp & Dohme B.V.
    Inventors: Iris Epkjen Hobo Van Der Graaf, Maurice Petrus Wilhelmus Tak, Juergen Schmidt, Hendricus Johannes Vertegaal
  • Patent number: 8864711
    Abstract: Methods for administering medication at or near an intervertebral spinal disc are provided. In various embodiments, a microporous uninflated balloon is inserted into a spinal disk and after insertion of the balloon into the disc space, a medication is inserted into the interior of the balloon. Due to both the pressure on the balloon from the spine and drug diffusion, the medication moves through the pores over time.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: October 21, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 8852258
    Abstract: A catheter assembly includes a catheter, including an inner member and a sheath, extending from a handle. The handle includes a housing, a braking assembly, a carriage and a carriage driver. The braking assembly comprises a braking element within the housing interior and a braking element rotator. The carriage comprises at least one carriage braking surface engaging the braking element. The carriage driver, such as a spring, biases the carriage towards the proximal end of the handle. The inner member has a proximal end secured to the housing. The sheath has a proximal end secured to the carriage. Rotating the braking element causes the carriage to move proximally as the carriage braking surface slides along the braking element. This causes the sheath to move proximally relative to the inner member.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: October 7, 2014
    Assignee: NovoStent Corporation
    Inventors: Alexander Arthur Lubinski, Eric W. Leopold, Gerald Ray Martin
  • Patent number: 8821474
    Abstract: A drug delivery device includes a first portion, formed primarily from elastomeric material, and a closure portion, cooperating with an opening of the first portion so as to complete an inflatable drug reservoir. The closure portion extends into the first portion inwards from the opening, defining at least one region of overlap between the first portion and the closure portion. The first portion and the closure portion define an outlet flow path for releasing a drug from the drug reservoir, with at least part of the outlet flow path passing between the first portion and the closure portion in the region of overlap. The region of overlap is disposed so as to be acted upon by a pressure within the drug reservoir thereby changing a flow impedance of the outlet flow path to provide an at least partially pressure compensated flow regulating mechanism.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: September 2, 2014
    Assignee: Microsert Ltd.
    Inventor: Avraham Shekalim
  • Patent number: 8784389
    Abstract: A method for replenishing gas in a subcutaneously implanted medical device containing functional cells comprising: inserting at least one needle, adopted to penetrate the skin and connecting a subcutaneously implanted medical device; connecting the inserted at least one needle to a gas replenishing apparatus; extracting gas from a gas reservoir in the implanted device into the gas replenishing apparatus; sensing oxygen level in the extracted gas; calculating the amount of gas needed for replenishing oxygen in the reservoir based on the sensed oxygen level in the extracted gas; and supplying gas from a gas tank in the gas replenishing apparatus to the gas reservoir in the implanted device.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: July 22, 2014
    Assignee: Beta-O2 Technologies Ltd.
    Inventors: Jacob Stern, Avi Rotem, Yoav Hevron, Yehezkel Bermer
  • Patent number: 8747391
    Abstract: An implantable pump includes a base plate and a can that are parts of the pump housing. The base plate bottom divides the housing into a first electronics chamber and a second chamber. A bellows mechanism is connected to the base plate and is disposed within the second chamber. The bellow mechanism has an expandable sidewall and a bottom plate. The bellow mechanism divides the second chamber into a medicament receiving portion and a non-medicament-receiving portion. The bellow mechanism has an intermediate plate disposed within the medicament-receiving portion. A coil is disposed in a recess on the lower surface of the base plate, and the coil is spaced from an internal wall of the recess. The amount of fluid remaining in the implantable pump can be monitored by energizing the coil. A primary magnetic field is generated by the energized coil.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: June 10, 2014
    Assignee: Codman Neuro Sciences Sarl
    Inventors: Rocco Crivelli, Jean-Sebastien Petithory, Philippe Margairaz, Thierry Utard, Alec Ginggen
  • Patent number: 8740871
    Abstract: A one-time use device to deliver preservative-free follicle stimulating hormone (FSH) solution is disclosed. The device includes a needle covered by a sliding needle shield, which covers the needle in all modes of the device. The device can be placed into a ready-to-use position in four or fewer user steps. The device has a knob for setting a desired dose of FSH. The knob includes longitudinally spaced elements respectively corresponding to the lock position and the seven or fewer discrete dosing positions. The device locks after one use and cannot be reused thereafter.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: June 3, 2014
    Assignees: Carebay Holding Ltd., Itero Biopharmaceuticals, Inc.
    Inventors: V. Bryan Lawlis, Kirk J. Hayenga, Darlene P. Horton, Lucio Giambattista, David Desalvo, Antonio Bendek
  • Patent number: 8652089
    Abstract: The present invention provides a system and a method for distending a body tissue cavity of a subject by continuous flow irrigation such that minimal or negligible fluid turbulence is present inside the cavity, such that any desired cavity pressure can be created and maintained for any desired outflow rate. The present invention also provides a method for accurately determining the rate of fluid loss, into the subject's body system, during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation or flow rate sensor. The system and the methods of the present invention described above can be used in any endoscopic procedure requiring continuous flow irrigation few examples of such endoscopic procedures being hysteroscopic surgery, arthroscopic surgery, trans uretheral surgery, endoscopic surgery of the brain and endoscopic surgery of the spine.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: February 18, 2014
    Assignee: Arthrex, Inc.
    Inventors: Atul Kumar, Alka Kumar
  • Patent number: 8588900
    Abstract: The perivascular leak repair system, and method of using the same, of the present invention provides a sealant reservoir with a repair catheter operably attached; a flow control device disposed between the sealant reservoir and the repair catheter, and the flow control device responsive to a flow control signal; a heart phase detector generating a diastole phase signal; an injection switch generating a injection signal; and a flow controller responsive to the diastole phase signal and the injection signal, and generating the flow control signal. A method of sealing a perivascular leak comprises identifying the perivascular leak; inserting a repair catheter to the perivascular leak; injecting sealant at the perivascular leak; and removing the repair catheter. The sealant can be injected when the heart is in diastole to sweep the sealant into the perivascular leak.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: November 19, 2013
    Assignee: Medtronic Vascular, Inc.
    Inventors: Jeffrey Allen, David Brin, Chris Coppin
  • Patent number: 8585662
    Abstract: A method for implanting an injection port within a patient. The method involves providing a port having a housing with a closed distal end, a open proximal end, a fluid reservoir therebetween, a needle penetrable septum attached to the housing about the opening, and at least one attachment mechanism mounted to the housing at a pivot point along an outer periphery of the housing. The attachment mechanism is an arcuate hook pivotable with respect to the housing, the arcuate hook having a length extending substantially at least 180° about the pivot point. The method further involves placing the distal end of the port adjacent tissue, and rotating the arcuate hook at least 180 degrees so that a free end of the hook extends into tissue and back out again.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: November 19, 2013
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Sean P. Conlon, Joshua Uth, How-Lun Chen
  • Patent number: 8562586
    Abstract: Devices and methods are provided for delivery of a positive inotropic agent to the heart of a patient in need thereof. An epicardial patch includes (i) a backing layer which is impermeable to the positive inotropic agent; and (ii) a drug release layer attached to the backing layer and including the positive inotropic agent and a polymeric membrane material. The polymeric membrane material provides controlled release of the positive inotropic agent to the epicardium to a region of the myocardium and in an amount effective to increase contractility. At least one of the backing layer or the drug release layer includes a tissue coupling portion for affixing the epicardial patch to an area of the epicardial surface. The epicardial patch is dimensioned and compliant to substantially avoid impeding myocardial functionality when affixed to the area of the epicardial surface.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: October 22, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Mark Lovich, Elazer Edelman
  • Patent number: 8562983
    Abstract: The invention provides systems for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: October 22, 2013
    Assignee: Proteon Therapeutics, Inc.
    Inventor: F. Nicholas Franano
  • Patent number: 8562591
    Abstract: Drug infusion system capable of delivering a fluid medication to a patient and method for doing same is described. An implantable drug delivery device is capable of delivering the fluid medication at a programmable rate to the patient under control of an original programming cycle having a plurality of steps in a plurality of time slots beginning at a starting time. The programming cycle specifies the programmable rate for each of the plurality of steps. An external controller is capable of storing a program representative of the original programming cycle in the implantable drug delivery device at a programming time. The drug infusion system adjusts the implantable drug delivery device so that the original programming cycle will begin at a time during the original programming cycle adjusted for the programming time.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: October 22, 2013
    Assignee: Medtronic, Inc.
    Inventors: Irfan Z. Ali, David C. Ullestad
  • Patent number: 8545477
    Abstract: Multiple reservoir implantable valve accumulator pump for the delivery of medication, and method of infusate delivery. The apparatus includes at least first and second infusate reservoirs in a common pressure chamber, each in fluid communication with a metering assembly. The metering assembly includes an accumulator that is preferably a fixed volume accumulator having an inlet and an outlet. A first valve is in fluid communication with the first infusate reservoir and an inlet of the accumulator, and a second valve is in fluid communication with the second infusate reservoir and an inlet of the accumulator. An outlet valve is in fluid communication with the outlet of the accumulator. The accumulator can be filled with infusate from the first and second infusate reservoirs sequentially, can be filled from the first infusate reservoir multiple times consecutively, the second infusate reservoir multiple times consecutively, or any combination or permutation thereof.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: October 1, 2013
    Assignee: Flowonix Medical Incorporated
    Inventors: Paul F. Burke, Joshua L. Buckman, Patrick J. O'Connor
  • Patent number: 8529542
    Abstract: Methods and systems for treating pleural disease comprising a providing a low dosage of a sclerosing agent over a period of time. Certain examples include catheter with a sclerosing agent that is inserted into the pleural space. The sclerosing agent is released in a sustained-release manner over a period of time to achieve diffuse pleurodesis of the pleural layers.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: September 10, 2013
    Assignee: UTI Limited Partnership
    Inventor: Alain Tremblay
  • Patent number: 8480655
    Abstract: A drug infusion system capable of delivering a fluid medication to a patient under direction of a medical professional continually at a basal rate and at an interval rate in each of a plurality of time slots over a specified period of time. The total dose of the fluid medication to be delivered to the patient over the period of time based on the basal rate and the interval rate for each of the plurality of time slots is determined, compared the total dose against a maximum dose. The basal rate is adjusted, if necessary, so that the total dose does not exceed the maximum dose.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: July 9, 2013
    Assignee: Medtronic, Inc.
    Inventors: Keith E. Jasperson, Thomas J. Valine, Frederic J. R. Wahlquist
  • Patent number: 8403907
    Abstract: A method is provided for monitoring the status of a medical device implanted in a patient. The method includes the steps of implanting in a patient a medical device which comprises (i) a substrate in which two or more reservoirs are located, with each covered by a reservoir cap, (ii) a drug or sensor located in the reservoir, (iii) a power source and actuation electronics for disintegrating or permeabilizing the reservoir cap, and (iv) a telemetry system; and then using said telemetry system to wirelessly transmit to a remote controller data about the condition of the power source and/or data about which reservoirs have been or have yet to be activated to release the drug therefrom or to expose the sensor therein.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: March 26, 2013
    Assignee: MicroCHIPS, Inc.
    Inventors: Norman F. Sheppard, Jr., John T. Santini, Jr., Michael J. Cima, Robert S. Langer, Dennis Ausiello
  • Patent number: 8399044
    Abstract: A method for coating medication for a medical product is disclosed. A technique for coating gel in a viscous semisolid state is provided to facilitate coating of medication. Coating of medication on an article can be facilitated using gel, and coating of medication on an article such as an article made of silk and an article made of polypropylene can be further facilitated.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: March 19, 2013
    Assignee: SNU R and DB Foundation
    Inventors: Jong-Sang Park, Dae-Joong Kim, In-Su Baek, Chengzhe Bai
  • Patent number: 8394075
    Abstract: A method is provided for suppressing or preventing pain in a patient. One step of the method includes positioning first and second electrodes, without penetrating the cranium, on or proximate to at least one of the sphenopalatine ganglia, the sphenopalatine nerves, or the vidian nerves on both sides of the patient's face. At least one of a medication solution, an analgesic, or an electrical signal is then applied to at least one of the sphenopalatine ganglia, the sphenopalatine nerves, or the vidian nerves through the first and second electrodes. Pain signal generation in, or transmission through, the at least one of the sphenopalatine ganglia, sphenopalatine nerves, or vidian nerves is disrupted on both sides of the patient's face.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: March 12, 2013
    Inventor: Mehdi M. Ansarinia
  • Patent number: 8361052
    Abstract: Methods and systems for treating pleural disease comprising a providing a low dosage of a sclerosing agent over a period of time. Certain examples include catheter with a sclerosing agent that is inserted into the pleural space. The sclerosing agent is released in a sustained-release manner over a period of time to achieve diffuse pleurodesis of the pleural layers.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: January 29, 2013
    Assignee: UTI Limited Partnership
    Inventor: Alain Tremblay
  • Patent number: 8267915
    Abstract: A port for implantation within a body, comprises a housing having proximal and distal surfaces and a side surface wherein, the proximal surface faces outward toward the skin, the distal surface faces inward away from the skin and the side surface extends between the proximal and distal surfaces. A first well formed within the housing includes a first opening in the proximal surface and a second well formed in the housing adjacent to the first well has a second opening formed in the proximal surface. First and second outlet openings formed on the side surface of the port are in fluid communication with the first and second wells, respectively, and are separated from one another by a distance substantially equal to a distance separating lumens of a dual lumen catheter to which the port is to be connected.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: September 18, 2012
    Assignee: Navilyst Medical, Inc.
    Inventors: Katie Daly, Kristian DiMatteo, Eric Houde
  • Patent number: 8241270
    Abstract: Drug infusion system capable of delivering a fluid medication to a patient and method for doing same. An implantable drug delivery device is capable of delivering the fluid medication at a programmable rate to the patient under control of an original programming cycle having a plurality of steps in a plurality of time slots beginning at a starting time. The programming cycle specifies the programmable rate for each of the plurality of steps. An external controller is capable of storing a program representative of the original programming cycle in the implantable drug delivery device at a programming time. The drug infusion system adjusts the implantable drug delivery device so that the original programming cycle will begin at a time during the original programming cycle adjusted for the programming time.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: August 14, 2012
    Assignee: Medtronic, Inc.
    Inventors: Irfan Z. Ali, David C. Ullestad
  • Patent number: 8124075
    Abstract: The invention includes a composition useful for preparing a tissue sealant for use on a patient, comprising: autologous fibrinogen, an activating agent and at least one supplement. The invention includes a method of treating a disc having at least one defect, comprising: introducing a composition into the disc, wherein the composition comprises autologous fibrinogen and an activating agent, and wherein the composition forms fibrin.
    Type: Grant
    Filed: July 14, 2005
    Date of Patent: February 28, 2012
    Assignee: Spinal Restoration, Inc.
    Inventors: Brian D. Burkinshaw, Steven I. Whitlock, James B. Rogan, Gerald L. Devries
  • Patent number: 8114055
    Abstract: A variable hydraulic resistor for use with implantable pumps is disclosed. The variable hydraulic resistor according to the present invention is particularly useful in varying the flow rate of a medication fluid from an otherwise constant flow implantable pump. An implantable pump is also disclosed, which does not require a complicated clinching system or the like, and which may include an undulating membrane and chamber design to reduce the height of the pump.
    Type: Grant
    Filed: May 10, 2005
    Date of Patent: February 14, 2012
    Assignee: Palyon Medical (BVI) Limited
    Inventor: Bernd Steinbach
  • Patent number: 8090445
    Abstract: A system for controlling an implantable medical device (e.g., a drug delivery device) susceptible to malfunctioning during exposure to a magnetic field and/or Radio Frequency field (e.g., during a magnetic resonance imaging procedure) and a method for operating the same. Exposure of the implantable device to the magnetic field and/or the Radio Frequency field is detected using the sensing device. When the detected magnetic field and/or Radio Frequency field exceeds a corresponding predetermined threshold level, an input signal is generated at the microcontroller.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: January 3, 2012
    Assignee: Codman Neuro Sciences Sárl
    Inventor: Alec Ginggen
  • Patent number: 8083730
    Abstract: An implantable medical device for delivering a therapeutic substance including a housing and a volume sensor assembly. The housing includes a stationary wall and maintains a reservoir containing the therapeutic substance and including a base wall movable relative to the stationary wall such that reservoir volume is a function of a spacing between the base wall and the stationary wall. The volume sensor assembly includes a cap, a shaft, a target, and circuitry. The cap defines a passage extending from an open end, and is mounted to the stationary wall such that the open end is open relative to a stationary wall inner face. The shaft has a first end attached to the base wall and a second end maintaining the target otherwise movably arranged within the passage. The circuitry generates information indicative of a longitudinal position of the target relative to the cap, and thus of the reservoir volume.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: December 27, 2011
    Assignee: Medtronic, Inc.
    Inventor: Keith A. Miesel
  • Patent number: 8048057
    Abstract: A catheter is provided for uniform distribution of fluid medication within an anatomical region. One embodiment of the catheter is comprised of an elongate tubular catheter body defining a lumen. A distal end of the lumen is closed and a portion of the catheter body includes a plurality of openings thereby defining an infusion section of the catheter. A tubular sheath is constructed from a porous material and is positioned over the infusion section. The tubular sheath extends at least a length of the infusion section. The tubular sheath and the catheter body are configured such that fluid within the lumen must pass through the tubular sheath to exit the catheter. In at least one embodiment, a pore size of the porous material is less than about 0.5 microns.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: November 1, 2011
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Jose Castillo Deniega, Roger Massengale, Kenneth W. Rake
  • Patent number: 7976534
    Abstract: Implantable medical devices include a sensor module capable of detecting an indicator of infection in proximity to the device. The sensor module is activated following a detection of an event associated with the device, such as, for example, refill of an implantable infusion device or implantation. The sensor module is deactivated two or more hours following activation. Methods include detecting a first event associated with an implanted medical device; activating a sensor module of the implanted medical device at or after the detection of the first event; deactivating the sensor module two hours or more after the sensor module is activated; and determining whether information regarding the indicator of infection is indicative of an infection.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: July 12, 2011
    Assignee: Medtronic, Inc.
    Inventors: Martin T. Gerber, John C. Rondoni
  • Patent number: 7967806
    Abstract: A method of delivering a fluid medication to a patient under direction of a medical professional continually at a basal rate and at an interval rate in each of a plurality of time slots over a specified period of time. The total dose of the fluid medication to be delivered to the patient over the period of time based on the basal rate and the interval rate for each of the plurality of time slots is determined, compared the total dose against a maximum dose. The basal rate is adjusted, if necessary, so that the total dose does not exceed the maximum dose.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: June 28, 2011
    Assignee: Medtronic, Inc.
    Inventors: Keith E. Jasperson, Thomas J. Valine, Frederic J. R. Wahlquist
  • Publication number: 20110118697
    Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more microjet applicators supported by the one or more substrates and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.
    Type: Application
    Filed: February 19, 2010
    Publication date: May 19, 2011
    Inventors: Philip A. Eckhoff, Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Eric C. Leuthardt, Dennis J. Rivet, Elizabeth A. Sweeney, Lowell L. Wood, JR., Victoria Y.H. Wood
  • Publication number: 20110118696
    Abstract: A device, a system, or a method is described for treating a disease or condition of one or more joints of articulating bone in a mammalian subject. A device is described which includes one or more substrates configured to contact one or more body contours at one or more joints of articulating bone of a mammalian subject; and an applicator supported by the one or more substrates and configured to inject one or more medicaments to one or more joint tissues of the mammalian subject.
    Type: Application
    Filed: February 19, 2010
    Publication date: May 19, 2011
    Inventors: Philip A. Eckhoff, Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Eric C. Leuthardt, Dennis J. Rivet, Elizabeth A. Sweeney, Lowell L. Wood, JR., Victoria Y.H. Wood
  • Patent number: RE43283
    Abstract: A blood collecting apparatus comprises a blood collecting needle 152; the blood collecting bag, a first tube whose one end communicates with the blood collecting bag and other end communicates with the blood collecting needle, the branch portion provided on a portion of the first tube, a second tube connected with the branch portion at one end thereof and having a blood take-out port (sampling port); and a flexible resin bag including a third tube communicating with the second tube. The flexible resin bag is capable of accommodating air inside a part of the first tube between the branch portion and the blood collecting needle and air inside the second tube when the blood collecting apparatus is used.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: March 27, 2012
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Noboru Ishida, Yoshihiro Yokoo, Hitoshi Kuroki