Abstract: A bone material dispensing device is provided. The bone material dispensing device comprises a housing having a proximal end, a distal end, and a longitudinal axis. The proximal end has a first opening and the distal end has a second opening. The first opening and the second opening are configured to slidably receive at least a portion of a plunger. A tubular member is provided that is pivotably connected to the housing and is configured for lateral movement relative to the longitudinal axis of the housing. The tubular member comprises a proximal opening, a distal opening and a channel disposed therebetween. The proximal opening, the distal opening and the channel of the tubular member are configured to receive at least the portion of the plunger. The tubular member is movable in a first position to align the proximal opening of the tubular member with the second opening of the housing to allow the tubular member to receive at least the portion of the plunger to dispense the bone material.

Abstract: The present disclosure describes methods of treating a ligament injury with ligament grafting.

Abstract: Methods of colon cleansing and/or inspection are described which safely maintain a colon in an uncollapsed state. Balanced replacement of a volume of fluid, gas and/or solids evacuated during cleansing of the colon is described. Replacement volume comprises, for example, cleansing fluid, jetting gas, and/or inflation gas. In some embodiments, balancing of evacuated and replacement volume is achieved under automatic control, based on monitored volume of material exchange, and/or measurement of resulting pressures.

Abstract: A system for reducing toxicity from intravascular triggered drug delivery includes a chamber comprising an inflow port, an outflow port, and a filter positioned upstream of the outflow port. A trigger module is configured to trigger the release of a drug from an intravascular triggered drug delivery system present in blood in the chamber. A method for reducing toxicity from intravascular triggered drug delivery includes the steps of removing blood comprising an intravascular triggered drug delivery system from a patient's vascular system and delivering the blood to a chamber, applying a trigger to the blood to release a drug from the intravascular triggered drug delivery system, filtering the drug from the blood, and returning the filtered blood to the patient.

Abstract: Medical devices and methods for delivering fluid. The medical devices include one or more needles for delivering fluid. The methods may include expanding an expandable member such as an inflatable member to expand an expandable scaffold outward toward a lumen wall.

Abstract: There is provided a process for treatment of rhinitis by diode laser ablation of the posterior nasal nerves. The laser diode delivery device with elongated optic tip is inserted through a patient's nostril and has the length, flexibility and a curvature to reach both above and under the patient's middle turbinate for treatment to both posterior nasal nerves. Skin and tissue temperature is raised to approximately 60-65° C. with the process. Optimal treatment wavelength was found to be approximately 380-450 nanometers with blue lasers.

Abstract: A peripheral intravenous catheter assembly may include a low-drag septum. The septum may include a body having a distal end and a proximal end, which may be sealed. The septum may include a slot disposed within an outer surface of the body and oriented along a longitudinal axis of the body. The slot may include a distal end spaced apart from the distal end of the body, and a proximal end spaced apart from the proximal end of the body. An introducer needle may extend through the slot.

Abstract: An occlusive implant system may include a catheter having a lumen extending from a proximal opening to a distal opening, a core wire slidably disposed within the lumen, and an occlusive implant having an expandable framework configured to shift between a collapsed configuration and an expanded configuration, and an occlusive element disposed on the expandable framework. The expandable framework may include a plurality of anchor members extending radially outward from the expandable framework, at least some of the plurality of anchor members each have a barb projecting circumferentially therefrom. The occlusive implant may be releasably connected to a distal portion of the core wire.

Abstract: A device for securing a catheter, or similar flexible medical tube or medical device to the skin of a patient. The device comprises a planar body (1) at least a lock retainer (5) and a passive retainer (6), both spaced-apart from each other. Furthermore a method of securing a catheter to a patient using a device as described.

Abstract: In some embodiments, the inventive subject matter is directed to a multimode electrosurgical system having an electrosurgical instrument with a first electrode configuration that operates in a bipolar mode and second electrode configuration that operates in a monopolar mode. In other embodiments, the inventive subject matter is directed to an instrument and system that provide multiple modes of surgical and/or therapeutic treatments, at least one being an electrosurgical mode of treatment, the instrument including at least one active electrode on a working portion, and the working portion including or supporting at least one non-electrosurgical functional element, the instrument including at least one operational return electrode configuration of selectively variable surface area.

Abstract: A dispenser actuator assembly (100) has base member (102) and an actuator arm (104) that is configured to crush a glass ampoule assembly (10). The glass ampoule assembly (10) has a rupturable glass ampoule (12) containing a flowable material (M). The glass ampoule (12) is contained within an outer container (14), the outer container (14) having a first open end (22) and a second closed end (24). The glass ampoule assembly (10) has an applicator (16) positioned in the first open end (22). The dispenser actuator assembly (100) has the base member (102) that is configured to mount on the outer container (14). The actuator arm (104) is pivotally connected to the base member (102). The actuator arm (104) is pivotable from a first position to a second position that is configured to engage the outer container (14) to crush the glass ampoule (12) wherein the flowable material (M) is dispensed from the glass ampoule assembly (10).

Abstract: An example occlusive implant is disclosed. The example occlusive implant includes an expandable framework configured to shift between a first configuration and an expanded configuration and a fixation member disposed along the expandable framework. The fixation member includes a first engagement portion and an anchor portion. Further, the first engagement portion is designed to be secured to the expandable framework and the anchor portion extends away from an outer surface of the expandable framework.

Abstract: A medical device configured to restrict medicament dispersion within a cerebrospinal fluid flow of the patient. The medical device including an implantable catheter having a distal end configured to be positioned within a flow of the cerebrospinal fluid, a proximal end, a body defining a lumen extending lengthwise along the implantable catheter configured to enable a flow of medicament from the proximal end to an infusion port located in proximity to the distal end, and a contoured surface defined by an exterior of the body in proximity to the infusion port configured to inhibit dispersion of the medicament within the cerebrospinal fluid.

Abstract: A needleless injector assembly can have a spring injector and an ampule. The spring injector can include a housing having a first housing portion and a second housing portion defining a bore and having a casing located in the bore and fixed relative to the first housing portion but the second housing portion can be rotatable relative to the casing. The casing can have a threaded receiving end at an end to threadedly receive a threaded end of an ampule. A pin having an end can project from the second housing portion and into an opening of the first housing portion and wherein the pin is retractable away from the first portion before the second housing portion is rotatable relative to the casing.

Abstract: A method for managing use of a disposable with an infusion pump is provided. The method can include adding validity information about a particular set of disposables to a list of disposables. Subsequent to adding the validity information, the method can include modifying the validity information about the particular set of disposables on the list of disposables. The method can include an infusion pump reading identifying information from a disposable, and can include determining whether the disposable is valid for use, based at least in part upon comparison of the identifying information read from the disposable by the infusion pump with the validity information about the particular set of disposables on the list of disposables. The method can also include the infusion pump making a determination of whether to deliver or not deliver an infusate based at least in part upon the determining whether the disposable is valid for use.

Abstract: There is provided a process for treatment of rhinitis by diode laser ablation of the posterior nasal nerves. The laser diode delivery device with elongated optic tip is inserted through a patient's nostril and has the length, flexibility and a curvature to reach both above and under the patient's middle turbinate for treatment to both posterior nasal nerves. Skin and tissue temperature is raised to approximately 60-65° C. with the process. Optimal treatment wavelength was found to be approximately 940 nanometers.

Abstract: A rotor for a pump has a housing and a rotor, and has at least one blade. The rotor is able to be actuated to rotate about an axis of rotation in order to convey a fluid in the axial or radial direction, and the rotor is able to be deformed in the radial direction between a first, radially compressed state and a second, radially expanded state. At a maximum speed of rotation of the rotor at which the power of the pump is at a maximum, the blade is essentially radially oriented, and/or the rotor has its maximum diameter.

Abstract: Systems and methods are provided for removing air from a medical device, such as a stent-graft and/or its delivery device. In an exemplary embodiment, the stent-graft or its delivery system or both are exposed to perfluorocarbon, by immersing the stent-graft or flushing the delivery device to remove air from the stent-graft. Optionally, the stent-graft and/or delivery system may be flushed multiple times, e.g., with perfluorocarbon before or after flushing with carbon dioxide, saline, a bio-inert gas, and the like. Thereafter, the stent-graft may be introduced into a patient's body and deployed at a target location, such as the site of an abdominal aortic aneurysm.

Abstract: Devices for removing clot material from a blood vessel lumen and associated systems and methods are disclosed herein. A clot retrieving device may include, for example, an elongated shaft, a capture structure, a cover, and a connector coupled to the distal zone of elongated shaft. The connector may include an inner band and an outer band. The inner band may at least partially surround the distal zone of the elongated shaft and a portion of the proximal region of the capture structure, and the outer band may at least partially surround the inner band. In some embodiments, the first end portion of the cover may be secured between the inner band and the outer band.

Abstract: Various embodiments of bulking or cushioning agents or material and related medical devices and methods are disclosed. For example, a method of performing a medical procedure in a tract of a body may include injecting a material in a liquid phase proximate a target site between a first tissue layer and a second tissue layer, allowing the material to transition from the liquid phase to the gel phase in response to a raise in temperature of the material to approximately at or above the predetermined temperature, and performing a surgical procedure on the target site. The material may have the liquid phase at temperatures below a predetermined temperature and a gel phase at temperature approximately at or above the predetermined temperature.

Abstract: Embodiments of the present disclosure are directed to conserving energy of an injection device that includes an energy source, an electronic component configured to be electrically decoupled from the energy source, a priming component configured to generate a trigger, and a mechanism attached to the priming component and configured to perform operations comprising in response to receiving the trigger, electrically coupling the energy source to the electronic component.

Abstract: A stent retriever assembly having a proximal end and a distal end and including a mesh tube having a distal and proximal end and being connected to a first wire. Also, a blood-porous fragment guard is at the distal end of the mesh tube and has a central hub and extending radially and proximally from the central hub. Further, a second wire is connected to the central hub, and when this second wire is pulled proximally relative to the first wire, the hub is pulled proximally, which thereby causes the fragment guard to deploy in expanded form.

Abstract: This terminal device is provided with: an acquisition unit which receives, from a server, information displayed on a display device used for medical treatment or care, and stores the received information in a storage unit; and a display control unit which displays the information on the display device. When a display stop condition, which indicates the likelihood that there is a difference between information stored in the server and information stored in the storage unit, is satisfied, the display control unit stops the display of at least information about biological information on a facility user who is a person requiring the medical treatment or care, among the information on the display device.

Abstract: A perfusion container for directly administering to patients a dose of an antineoplastic drug calculated according to a patient's parameter, wherein the first perfusion container comprises a solution of antineoplastic drug at a concentration and volume such that the amount of antineoplastic drug in the container is equal to the calculated dose for one patient but less than the calculated dose for a second patient, the calculated dose is provided to first patient within 5% variance by directly administering the full volume of the solution of antineoplastic drug from the first perfusion container, further the first perfusion container is accompanied by a second top-up perfusion container comprising a solution of antineoplastic drug at a concentration and volume such that the calculated dose is provided within 5% variance by directly administering the full volume of the solution of antineoplastic drug from the first perfusion container and the second top-up container to the second patient.

Abstract: The present disclosure relates to a self-administrative medicament device (1) comprising: processing circuitry (3), a transmitter (9) having a first electrode (7a) configured to be coupled to a user's skin, a power supply system (11) configured to apply a current to the transmitter, and a trigger member (7) configured to trigger the power supply to apply the current to the transmitter (9), wherein the processing circuitry (3) is configured to modulate the current generated by the power supply system (11) to encode medicament administration-related data to be transmitted through a user's skin by the transmitter (9) via the first electrode (9a).

Abstract: An introducer sheath system including an outer layer, an inner layer, and a dilator is disclosed. The outer layer is circumferentially extending between a first longitudinal edge and a second longitudinal edge. An expandable gap is defined between the first and second longitudinal edges. The inner layer is disposed within the outer layer. The inner layer is configured to be continuously circumferentially expandable. The inner layer includes a non-extended state having a circumferential portion extending circumferentially inside the outer layer and a fold portion extending into an interior cavity of the inner layer. The inner layer includes an extended state wherein the fold portion extends at least partially circumferentially between the first and second longitudinal edges. The dilator is extendable longitudinally within the inner layer. The dilator includes a recess configured to accommodate the fold portion of the inner layer.

Abstract: Some embodiments of an infusion pump system can employ a number of power management techniques to avoid using substantially excessive power during operation of the pump drive system. Thus, the infusion pump system can draw upon the energy supply in an efficient manner that extends the useful life on the power supply. Furthermore, the infusion pump system can be configured estimate an amount of power remaining to operate the pump system without the requirement of directly detecting the remaining charge on power supply device (e.g., without detecting the remaining charge on a battery). As such, the infusion pump system can readily inform a user of a particular estimated amount of time remaining for medicine dispensing operations.

Abstract: Apparatuses and methods for delivering a fluid, including a viscous fluid. These apparatuses may include a fluid reservoir, two or more piston chambers, a manifold, a delivery port, and a drive assembly and may be configured to inject either a predetermined amount of fluid or a continuous stream of fluid. These apparatuses may also be configured to switch between filling, injection and aspiration modes. These apparatuses may generally be hand-held and lightweight and may provide a significant mechanical advantage to the user.

Abstract: A medical device for infusing medical substances has activation buttons accessible on the exterior of the device housing. Activation buttons and corresponding electrical switches within the housing are configured to prevent inadvertent activation of the buttons and therefore inadvertent operation of the switches to initiate a process such as medical substance delivery to the user. The device employs overlap of respective time traces initiated by activation of the activation buttons to determine whether activation is intended and valid. These time traces do not have to be initiated simultaneously or in any particular sequence. The activation buttons can be elastomeric overmolded buttons set within cutouts in the housing, and, when depressed, make physical contact with respective switches.

Abstract: In one aspect the present disclosure refers to a supplementary device for an injection device, the supplementary device comprising: a body attachable to a housing of the injection device, the body having a first portion facing towards the housing when attached to the housing, at least one light source attached to the body, and at least a first optical coupling located in or at the first portion, connected to the at least one light source in a light transmissive way and optically connectable to a second optical coupling arranged in or on the housing.

Abstract: A guide catheter for use in treating sinuses, the catheter including a catheter shaft configured to provide suction about a balloon catheter and a distal portion shaped for navigating body anatomy. In one embodiment, the guide catheter includes a valve for sealing the balloon catheter and a vent for controlling suction.

Abstract: A drug delivery device comprises a medicament reservoir attached to a housing, a drive mechanism comprising a plunger movable relative to the housing, a dose selecting element releasably coupled to the drive mechanism and rotatable relative to the housing, a trigger axially movable relative to the housing, and a limiter selectively permitting and preventing axial movement of the trigger depending on the amount of a selected dose. The limiter is constrained to the dose selecting element and to the trigger. One of the limiter or a component part is axially coupled to the housing comprises a track which is in engagement with a blocking feature of the other of the limiter or the component part axially coupled to the housing. The track comprises a narrow section limiting relative movement between the track and the blocking feature and a wide section permitting relative movement between the track and the blocking feature.

Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

Abstract: Catheter-based devices and methods for endoluminally accessing and occluding hollow anatomical structures are disclosed. Occlusion clips are contained in one or more needles that pierce opposing walls of the anatomical structure to deploy the clips externally of the structure. The clips then are drawn together to press the opposing anatomical walls together.

Abstract: Systems and methods for treating a subject are provided. A first dataset comprising timestamped autonomous glucose measurements of the subject over a first time course is obtained. A second dataset, associated with a standing insulin regimen for the subject over the first time course and comprising insulin medicament records, is also obtained. Each record comprises a timestamped administration event including an amount and type of insulin medicament administered into the subject by an insulin delivery device. The first and second datasets serve to calculate a glycemic risk measure and an insulin sensitivity factor of the subject during the first time course, which are used to obtain a basal rate titration schedule and a fasting blood glucose profile model over a subsequent second time course for the subject. The model predicts the fasting blood glucose level of the subject based upon amounts of insulin medicament administered into the subject.

Abstract: A system can automatically adjust flow rates/feeding regimen of a feeding pump feeding fluids/enteral nutrition to a patient. The system can, based upon a prescribed volume of nutrition or nutritional targets (such as and not limited to energy (calories), protein etc.) to be delivered and a prescribed delivery duration, adjust the pump flow rate/feeding regimen following unexpected delivery interruptions to achieve at or near to the prescribed total volume/nutritional targets to be delivered, despite the interruptions.

Abstract: A method of controlling a robotic arm in a surgical system comprises manually applying a force to a body of the robotic arm. Force information is received from a gesture force sensor on the robotic arm and a controller determines, using the force information, whether the force is a gesture force input. If the force is determined to be a gesture force input, the controller initiates a predetermined system function. The predetermined system function may be a change in operational state, movement between operational modes, or a movement from a first configuration of the arm's joints to a second, predetermined, configuration of the arms joints.

Abstract: The present disclosure relates to the field of endoscopy. Specifically, the present disclosure relates to systems and methods which allow the distal portion of a catheter to be visualized within the body using a colored marker and one or more secondary markers. In particular, the present disclosure relates to systems and methods which indicate when a medical device is properly positioned for deployment within a body lumen.

Abstract: An infusion set (1) includes: a first flow path (10a) having a first connector (11a) and a downstream connector (19); a first open/close valve (12a), a first liquid surface sensor (13a), a second liquid surface sensor (13b), a drip chamber (14), and a variable valve (17) that are provided in this order on the first flow path from the first connector side toward the downstream connector side; a droplet sensor (15) with which the drip chamber is provided; a second flow path (10b) having a second connector (11b); and a second open/close valve (12b) provided on the second flow path. The second flow path is in communication with a portion of the first flow path between the first liquid surface sensor and the second liquid surface sensor. The controller is configured to control the first and second open/close valves and the variable valves based on signals from the first and second liquid surface sensors and the droplet sensor.

Abstract: A method includes providing microvalve device having inner and outer catheters, and a filter valve attached to the distal end of the inner and outer catheters. Longitudinal displacement of the inner catheter relative to the outer catheter moves the filter valve from a non-deployed configuration to a deployed configuration. With the inner catheter longitudinally advanced a first amount relative to the outer catheter, the filter valve is in a reduced first diameter for advancement of a guidewire to a target location. Once the filter valve reaches the target location, the inner catheter is moved relative to the outer catheter such that the filter valve assumes a larger second diameter. A therapeutic agent is infused through the inner catheter and beyond the filter valve.

Abstract: The invention relates to an immersion matrix (5), designed for adjusting optical properties at interfaces of optical arrangements, having a porosity with pores of at least one pore size selected from a range from >20 nm to 200 ?m and/or nanopores in the material of the immersion matrix (5), wherein the nanopores have at least one average pore size selected from a range of 0.5 nm to 20 nm, and an elasticity modulus E selected from a range of 0.1-100 MPa. The invention furthermore relates to the use of the immersion matrix (5), an arrangement with the immersion matrix and an immersion device.

Abstract: Described are implantable devices having expandable reservoirs for the sustained release of therapeutic agents. The device is configured to be at least partially implanted in an eye and includes a retention structure and a penetrable element coupled to and extending within at least a portion of the retention structure. A porous drug release mechanism is positioned in fluid communication with an outlet of the device; and a reservoir having a volume configured to contain one or more therapeutic agents is in fluid communication with the outlet through the porous drug release mechanism. The device is at least partially inserted along an axis of insertion. The reservoir enlarges from an insertion configuration having a first three-dimensional shape to an expanded configuration having a second three-dimensional shape, the second three-dimensional shape being eccentrically positioned relative to the axis of insertion.

Abstract: In some embodiments, an insertion device for a single port robotic surgery apparatus includes a plurality of instrument channels positioned in an interior of a housing and extending along substantially an entire length of the housing, the plurality of instrument channels configured to removably house a plurality of surgical instruments, a plurality of openings in a rear exterior surface of the housing, the plurality of openings providing access to the plurality of instrument channels and configured to facilitate insertion of the plurality of surgical instruments into the plurality of instrument channels, and an illumination device supported at least partially at the rear exterior surface of the housing and positioned proximal to the plurality of openings, the illumination device configured to illuminate the openings to facilitate insertion of the plurality of instruments through the plurality of openings.

Abstract: Applicators for a microprojection array and methods of using the applicators are described.

Abstract: There is disclosed a device and method for delivering constant target current to a muscle for electro-stimulation of that muscle. One device is a completely self-contained device with no external means for the adjustment and control of the electro-stimulation delivered to the muscle during treatment. The microprocessor based device monitors indirectly the actual current delivered to the muscle during electro-stimulation via measurement of the return path voltage through the muscle and optionally in addition monitors and adjusts for the internal battery voltage during use of the device in order to deliver a more consistent an accurate and effective target output current to the muscle being stimulated at each and every pulse delivered from the device. The device is pre-programmed with an electro-stimulation treatment cycle and the whole treatment cycle, including the monitoring and adjustment required to achieve this treatment cycle, is automatic within the device.

Abstract: An assembly for advancing a piston through a rotationally fixed cartridge includes a rotatable, axially fixed first member and an axially movable, rotatable second member connected thereto via a threaded connection and connectable to the piston. A friction pad is rotationally fixedly connected with the second member and includes first and second sets of fingers extending radially outwardly from a central disk. Both the first and second sets of fingers are configured to contact an interior side wall of the cartridge. The first set of fingers are angled toward a first rotational direction and are configured to wedge the friction pad between the side wall and the second member upon rotation of the first member in the first direction, thereby substantially preventing rotation in the first direction. The second set of fingers are angled toward a second rotational direction and are configured to substantially prevent rotation in the second direction.

Abstract: Systems, methods, and devices provide alarms and alerts in an on-body networked diabetes management system. Methods may include receiving glucose sensor data from a continuous glucose monitor and determining a dosage of insulin delivery based at least in part on the glucose sensor data. The method may include detecting an alarm or alert condition, and sending a wireless communication regarding the alarm or alert condition to a remote user-interface device. The method may include triggering an audible, visual, or haptic alarm or alert on the insulin delivery device unless an acknowledgement of the alarm or alert condition is received within a predetermined period of time.

Abstract: A combination hanger arm extension and pump cover device can be used with an instillation unit. The device includes a body portion that has a first end and a second end. A hook extends from the first end, and a tab extends from the body proximate the hook. A panel is disposed proximate the second end. A substantially rectangular sleeve extends at least partially through the body. The sleeve is disposed between the first and second end.

Abstract: A user-wearable patch pump system for delivery of insulin or other medicament can include a pump and an attachment portion that attaches the pump to a user's body. The pump can include a drive unit and a disposable cartridge containing a medicament with the drive unit configured to cause the pump to deliver the medicament in the cartridge to the user. The attachment portion can include a retention frame configured to selectively retain the pump therein and an adhesive patch configured to be attached to the user's body. The pump can be selectively attached to the retention frame and used to deliver medicament either through a cannula to an infusion site directly beneath the retention frame or through tubing to an infusion site displaced from the retention frame.

Abstract: Improved methods and devices for performing an endoscopic surgery are provided. Systems are taught for operatively treating gastrointestinal disorders endoscopically in a stable, yet dynamic operative environment, and in a minimally-invasive manner. Such systems include, for example, an endoscopic surgical suite. The surgical suite can have a reversibly-expandable retractor that expands to provide a stable, operative environment within a subject. The expansion can be asymmetric around a stabilizer subsystem to maximize space for a tool and an endoscope to each be maneuvered independently to visualize a target tissue and treat the target tissue from outside the patient in a minimally invasive manner.