Therapeutic Material To Facilitate Ocular Treatment Patents (Class 604/521)
  • Patent number: 9439908
    Abstract: An improved formulation of an ophthalmic composition contains riboflavin, as cross-linking agent of corneal collagen, administered by corneal iontophoresis, able to guarantee an increased capacity of permeation of riboflavin of the corneal stroma and therefore greater therapeutic efficacy in the treatment of keratoconus.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: September 13, 2016
    Assignee: SOOFT ITALIA SPA
    Inventors: Fulvio Foschini, Marcello Stagni, Giulio Luciani, Pierre Roy
  • Patent number: 9433629
    Abstract: The present invention provides a formulation comprising a corticosteroid and an insulin analog or pharmaceutical compositions thereof. Also provided is a formulation comprising a corticosteroid, insulin lispro and at least one organic acid or pharmaceutical compositions thereof. The present invention provides methods for stimulating bone and/or cartilage growth, for treating tendon and/or ligament damage, for stimulating hair growth and/or reducing hair loss, for stimulating growth of a tooth and/or periodontium and for treating tumors and cysts of the jaw by administering the formulations described herein.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: September 6, 2016
    Inventors: Juan Paz Garcia, Brenda Astrid Paz Michel
  • Patent number: 9339514
    Abstract: A method of treating glaucoma or other eye disease in a patient is provided. The method includes injecting an eye of the patient with a cohesive monophasic gel containing cross-linked hyaluronic acid or its salt. The injection can be under the scleral flap and/or conjunctiva of the eye, thereby creating and maintaining a conjunctival bleb, and/or the injection can be in the supra-scleral and/or supra-choroidal (sub-scleral) space of the eye thereby reducing the intraocular pressure.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: May 17, 2016
    Assignee: APTISSEN SA
    Inventors: Gilles Bos, Philippe Sourdille
  • Patent number: 9289584
    Abstract: Drug delivery devices responsive to at least one external stimulus are described, along with methods for their preparation and use. The devices can be configured to respond to the stimulus, providing “on demand” release of one or more deliverables such as pharmaceutical drugs.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: March 22, 2016
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Mu Chiao, John K. Jackson, Fatemeh N. Pirmoradi, Kevin Ou
  • Patent number: 9173770
    Abstract: A method is disclosed for making a porous punctal plug by providing a multi-filament fibrous strand and extrusion coating the fibrous strand with a polymeric material coating and cutting the coated fibrous strand to adequate length for insertion into a mammal's punctal opening.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: November 3, 2015
    Inventor: Amad Tayebi
  • Patent number: 9084662
    Abstract: Disclosed are devices and methods for treatment of eye disease. The suprachoroidal space is used as a conduit within which to place a drug delivery device. One such drug delivery device may be a tube, wicking element, bioabsorbable polymer structure, or other configuration of drug delivery substrate. The delivery device may include a port on the proximal end to assist in repeat injection, and may include a reservoir to either collect flow from the aqueous to concentrate it along the length of the device, or act as a repository for injected agent.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: July 21, 2015
    Assignee: Transcend Medical, Inc.
    Inventors: Hanson S. Gifford, III, Angela MacFarlane, Cary Reich
  • Publication number: 20150133895
    Abstract: The invention relates to a device (1) for use in eye surgery, comprising a container (9) with fluid (5) which is connected via an irrigation line (12) to a surgical handpiece for delivering the fluid (5) for rinsing an eye (3) on which surgery has been performed, wherein a pillar (8), which in particular is electrically adjustable in its height, is provided for supporting the container (9) and for adjusting the height (H) between the container (9) and the surgical handpiece, and wherein a control for adjusting the height of the pillar (8) is provided in order to deliver the fluid (5) from the surgical handpiece into the eye (3) at an irrigation pressure predetermined by the surgeon, wherein pressurizing means (10) are provided which are designed for charging the fluid (5) to be delivered from the container (9) to the irrigation line (12) with an atmospheric overpressure (PATÜ) and wherein the control for adjusting the desired irrigation pressure is designed both for adjusting the height (H) of the pillar (8)
    Type: Application
    Filed: May 8, 2013
    Publication date: May 14, 2015
    Applicant: EOS GMBH
    Inventor: Manfred Klomp
  • Publication number: 20150132358
    Abstract: A method and apparatus for administering an active agent such as a medicine to a subject, uses an ocular implant such as a punctal plug, to which the active agent has been applied. The implant is installed at the eye of the subject for administering the active agent via tissues of the eye.
    Type: Application
    Filed: August 29, 2014
    Publication date: May 14, 2015
    Inventors: Steven A. Odrich, Liane C. Glazer
  • Publication number: 20150133896
    Abstract: A bioresorbable drug eluting intravitreal implant system includes a syringe with a chamber containing a medicinal drug. A balloon is releasably secured to a needle where the needle has a central section chamber in fluid communication with a chamber in the syringe. The needle central section has an opening formed through a wall for transporting the medicinal drug to the interior of the balloon subsequent to insertion of the needle through the sclera of a patient's eye.
    Type: Application
    Filed: October 10, 2014
    Publication date: May 14, 2015
    Inventors: JEFFREY D. BENNER, STEVEN M. COHEN
  • Publication number: 20150126970
    Abstract: A conjunctival cover including an annular generally curved shell having a conjunctival portion structured to conform to and overly at least part of the conjunctiva of an eye. The annular generally partially spherical shell defines a generally central opening. The central opening is sized to leave a cornea of the eye substantially or partially uncovered when the conjunctival cover is applied to the eye.
    Type: Application
    Filed: November 4, 2013
    Publication date: May 7, 2015
    Inventor: Vance M. Thompson
  • Patent number: 9011361
    Abstract: This document discusses, among other things, an apparatus comprising a lacrimal implant insertable at least partially into a lacrimal punctum. The lacrimal implant comprises an implant core, and an implant body. The implant body includes a cavity sized and shaped to receive the implant core. At least one of the implant core and the implant cavity includes a detection device configured to allow automatic detection of the lacrimal implant with a separate detector device.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: April 21, 2015
    Assignee: Mati Therapeutics Inc.
    Inventors: Eugene de Juan, Jr., Stephen Boyd, Cary J. Reich, Christopher V. Cardenas, Tommy Jewell, Lorrie Ma, Ngoc-Tuan Nguyen
  • Patent number: 9005099
    Abstract: Delivery systems and methods for delivering riboflavin (R/F) and UVA irradiation to the sclera are disclosed. The R/F is delivered and then activated with UVA irradiation through the use of LEDs or optical fibers, thereby causing cross-linking of the collagen tissue. Delivery systems include implantable structures which provide surfaces that conform to the sclera. The delivery systems include various types of structures for delivery of R/F onto the sclera surface. Additionally, the delivery systems include UVA sources which provide irradiation of R/F in sclera collagen tissue.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: April 14, 2015
    Assignee: Seros Medical, LLC
    Inventors: Mark S. Blumenkranz, Edward E. Manche, Satish V. Herekar, Donald J. Eaton
  • Patent number: 8998881
    Abstract: A method for delivering a drug into tissue includes the steps of: providing a drug delivery device having at least one nozzle and a drug contained in a portion of the device; identifying a site for delivery of the drug in or on tissue; placing a portion of the device on or near the site; and delivering the drug into the tissue at the site through at least one nozzle of the device under microjet propulsion.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: April 7, 2015
    Assignee: Alza Corporation
    Inventor: Scott J. Gilbert
  • Publication number: 20150088099
    Abstract: An eye drop assist apparatus and method for sequentially administering an ocular medication into a patient's eyes. A bottle or vial containing liquid eye drops is supported in a holder. First and second nasal locators extend in opposite directions from the holder. The nasal locators are separated by the pupillary distance (typically 60 mm), with the dispensing tip of the bottle located mid-way between. A person administering eye drops abuts the first nasal locator against the top of the patient's nasal bridge while aligning the tip of the bottle directly over a first eye before squeezing the bottle to forcibly expel one or more drops into the first eye. The person then linearly translates the bottle so that the second nasal locator abuts against the top of the patient's nasal bridge while aligning the tip of the bottle directly over a second eye. The bottle is then squeezed again to forcibly expel drops into the second eye.
    Type: Application
    Filed: September 15, 2014
    Publication date: March 26, 2015
    Inventors: David Lorch, Marius Tijunelis
  • Patent number: 8979821
    Abstract: A biomaterial mass is inserted through a punctum into a canaliculus in the lacrimal outflow system with a syringe. The mass has an outer cross section that is less than the inner cross section of the canaliculus. The mass absorbs liquid to swell to form a lacrimal filler or sealing mechanism. The lacrimal filler has an external cross section that conforms to the internal cross section of the canaliculus and a soft outer surface relative to the surrounding tissues to prevent erosion of the canaliculus lining. The lacrimal filler forms an occlusion that prevents the outflow of liquid through the lacrimal outflow system to retain tears within the eye to maintain eye lubrication and wetness. The mass and syringe are provided in kit with a rubber stopper and, optionally, a punctal dilator, an injecting catheter, and an enzyme for dissolving or degrading the lacrimal filler at a later time.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: March 17, 2015
    Assignee: Fezza Family Properties, LLC
    Inventor: John Fezza
  • Publication number: 20150025506
    Abstract: The present invention relates to an apparatus and method for delivering a fluid, and particularly, but not exclusively, to an apparatus and method for delivering a fluid to an eye. The apparatus provides a useful device that assists users to accurately deliver fluid to the eye and includes features that make using the apparatus more comfortable.
    Type: Application
    Filed: September 21, 2011
    Publication date: January 22, 2015
    Applicant: FormationD Pty Ltd
    Inventor: Eric Chau
  • Publication number: 20140358125
    Abstract: A therapeutic device that can release a therapeutic agent comprising a porous structure coupled to a container comprising a reservoir. The reservoir can comprise a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in a patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
    Type: Application
    Filed: August 3, 2012
    Publication date: December 4, 2014
    Applicant: ForSight Vision4, Inc.
    Inventors: Eugene de Juan, JR., Yair Alster, Kathleen Cogan Farinas, K. Angela MacFarlane, Cary J. Reich, Randolph E. Campbell, Signe Erickson
  • Publication number: 20140358124
    Abstract: The invention is a device and a method for delivering a dose of a pharmaceutical agent to the eye. The device and method provide a safe and effective way to instill a specified dose of the agent to the eye virtually independent of gravity and posture. The device includes a filter matrix in which the fluid capture and release properties can be modified. The filter matrix is attached to a flexible handle with an impermeable or semipermeable membrane there between.
    Type: Application
    Filed: May 29, 2013
    Publication date: December 4, 2014
    Inventors: Terry Glasser, Spencer Obie
  • Publication number: 20140336618
    Abstract: The present disclosure relates to ejector mechanisms and devices for generating a directed stream of droplets, as well as improved methods for delivering an ejected stream of droplets to a target. The device and methods may be useful for the delivery of fluid for ophthalmic, topical, oral, nasal, or pulmonary use, more particularly, for use in the delivery of ophthalmic fluid to the eye. Certain aspects of the disclosure relate to devices and methods for the delivery of a therapeutically effective low dosage volume medicament composition to a target, e.g., by controlling charge, droplet size and/or droplet deposit parameters of the medicament composition.
    Type: Application
    Filed: April 10, 2013
    Publication date: November 13, 2014
    Applicant: CORINTHIAN OPHTHALMIC, INC.
    Inventors: Jonathan Ryan Wilkerson, Iyam Lynch, Charles Eric Hunter, Joshua Richard Brown, Lucien S. Wilkins, Peter Lam, Hamilton Coleman, J. Sid Clements, Bernard L. Ballou, JR.
  • Publication number: 20140336619
    Abstract: An ophthalmic shunt includes a seal or septum through which multiple injections of the therapeutic agent can be made as needed, thereby avoiding repeated injury to the sclera. The therapeutic agent is temporarily carried in a tube connected to the septum. The therapeutic agent release may be rapid or sustained over a period of time.
    Type: Application
    Filed: May 13, 2013
    Publication date: November 13, 2014
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventor: Abbott Cardiovascular Systems Inc.
  • Patent number: 8852139
    Abstract: Devices, systems, and methods for treatment of an eye alter aspiration flow from the eye in response to an occlusion of the aspiration conduit pathway. Where aspiration is drawn from the eye using a volumetric pump, the pump can be reversed so as to induce fluid reflux from the aspiration conduit pathway into the eye to help clear the occlusion. The pump may vary the reverse flow in response to sensed aspiration pressure or the like, and the reverse flow may be halted before the pressure within the aspiration conduit pathway adjacent the eye significantly exceeds the irrigation fluid pressure and/or the pressure within the eye. Reflux may alternatively be generated by modulating a vent valve disposed between an irrigation conduit pathway and the aspiration conduit pathway.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: October 7, 2014
    Assignee: Abbott Medical Optics Inc.
    Inventors: David King, John I. Muri, Thomas B. Sutton
  • Publication number: 20140276638
    Abstract: The present invention relates generally to providing pressurized infusion of liquids and, more particularly, is directed to providing a stable and pressurized flow of irrigation fluid to the eye during surgery.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Inventor: Abbott Medical Optics Inc.
  • Publication number: 20140276639
    Abstract: The present invention relates generally to providing pressurized infusion of liquids and more particularly, is directed to providing a stable and pressurized flow of irrigation fluid to the eye during surgery.
    Type: Application
    Filed: May 13, 2014
    Publication date: September 18, 2014
    Applicant: Abbott Medical Optics Inc.
    Inventors: Branden J. Tarkeshian, Mark E. Steen, James B. Gerg, Fred Lee
  • Publication number: 20140249509
    Abstract: A first sponge device for use to manipulate and prepare the surface of the epithelium of an eye prior to application of an ophthalmic solution has a handle and a sponge head secured to the handle. The head is made of an absorbent, wicking sponge material and has a non-sharp, tissue preparation surface of predetermined shape for rubbing across the surface of the epithelium layer in order to manipulate the tissue. After the surface is prepared, a second, holding sponge is placed over the eye to act as a reservoir and to hold ophthalmic solution against the eye surface.
    Type: Application
    Filed: May 12, 2014
    Publication date: September 4, 2014
    Applicant: CXL Ophthalmics, LLC
    Inventors: Roy S. Rubinfeld, Wayne Korteweg
  • Publication number: 20140243795
    Abstract: A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.
    Type: Application
    Filed: May 2, 2014
    Publication date: August 28, 2014
    Applicant: JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Signe Erickson Varner, Eugene de Juan, JR., Aaron Christopher Barnes, Terry Harrison Shelley, Michael J. Cooney
  • Publication number: 20140206940
    Abstract: The method and system disclosed herein uses a pulsatile, dilatory bubble at the tip of a catheter to facilitate tissue separation and ease catheter insertion for, among other applications, delivery of therapeutics to the posterior of the eye while reducing procedure-related trauma. In some implementations, the method is extended to other dilatory and catheter-insertion applications elsewhere in the body. In brief, the disclosure discusses iteratively injecting liquid through a catheter to form a bubble near the distal tip of the catheter. The liquid is withdrawn to create a void, and the catheter is advanced into the void. The process is repeated until the distal tip of the catheter reaches the target location.
    Type: Application
    Filed: January 24, 2014
    Publication date: July 24, 2014
    Applicant: The Charles Stark Draper Laboratory, Inc.
    Inventor: Kevin A. Hufford
  • Patent number: 8778886
    Abstract: A peptide-POD with ability to penetrate and deliver fluorophores, siRNA, DNA and quantum dots to cells in culture and retinal and ocular tissues in vivo is provided herein. POD couples to adenovirus vectors, enhancing tropism for certain cells, potentially providing a safer and more efficacious method to deliver molecules to ocular and other tissues in vivo. POD constructs are therapeutic delivery vehicles for treating cells and tissues, including ocular cells and tissues suffering from retinal degeneration.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: July 15, 2014
    Assignee: Tufts University
    Inventors: Rajendra Kumar-Singh, Siobhan M. Cashman, Sarah Parker Read
  • Patent number: 8771217
    Abstract: Shunt devices and a method for continuously decompressing elevated intraocular pressure in eyes affected by glaucoma by diverting excess aqueous humor from the anterior chamber of the eye into Schlemm's canal where post-operative patency can be maintained with an indwelling shunt device which surgically connects the canal with the anterior chamber. The shunt devices provide uni- or bi-directional flow of aqueous humor into Schlemm's canal.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: July 8, 2014
    Assignee: Glaukos Corporation
    Inventors: Mary G Lynch, Reay H Brown
  • Patent number: 8771256
    Abstract: The invention concerns a device for ocular application of an active principle (1) comprising a main electrode (2) including an insulating layer, an adhesive layer designed to bind the insulating layer to a conductive layer, characterized in that the main electrode comprises a zone (21, 22) designed to be urged into contact with an eyelid.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: July 8, 2014
    Assignee: Eyegate Pharma S.A.
    Inventors: Francine Behar-Cohen, Pierre Roy
  • Patent number: 8771255
    Abstract: A method and apparatus for a suture less injectable retinal detachment sponge and method for placing the sponge in a pocket beneath the surface of the sclera is the subject of the present invention. An exterior accessible pocket can be created in the sclera by making an incision in the outer surface. The incision can be made utilizing a crescent blade. The apparatus used to perform the procedure for insertion of the sponge in the pocket utilizes an injector having a cylinder and plunger combination. The cylinder can have a sponge removably contained therein and a plunger for injecting the sponge out of the cylinder portion of the injector to the desired location within the pocket.
    Type: Grant
    Filed: April 7, 2008
    Date of Patent: July 8, 2014
    Assignee: Saint Louis University
    Inventor: Levent Akduman
  • Publication number: 20140187969
    Abstract: A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.
    Type: Application
    Filed: March 7, 2014
    Publication date: July 3, 2014
    Applicant: Corinthian Ophthalmic, Inc.
    Inventors: Charles Eric HUNTER, Bernard L. BALLOU, JR., Jurgen Klaus VOLLRATH, Arthur H. TEW, Joshua Richard BROWN, James Thornhill LEATH, Nathan R. FAULKS, Bradley G. JOHNSON, J. Sid CLEMENTS, Phillip E. RUSSELL, John H. HEBRANK, Tsontcho INACHULEV, Mark PACKER, Troy ELLIOTT, Walter M. FIERSON, Thomas J. LINDNER
  • Publication number: 20140180253
    Abstract: Lacrimal implants for treating diseases or disorders are disclosed. More particularly, lacrimal implants, methods of making such implants, and methods of treating ocular, respiration, inner ear or other diseases or disorders using such implants are disclosed.
    Type: Application
    Filed: February 28, 2014
    Publication date: June 26, 2014
    Applicant: Mati Therapeutics Inc.
    Inventors: Alan R. Rapacki, Valery Rubinchik, John B. Holds, Sylvie Sim, Danny Shen
  • Patent number: 8755880
    Abstract: The present invention includes methods and devices for delivering an active agent into the eye of a subject. One such device may include an anode assembly having an anode housing and an anode configured to electrically couple to a power source, the anode assembly being configured to contact and remain against a surface of the eye. The device may also include a cathode assembly having a cathode housing and a cathode configured to electrically couple to the power source, the cathode assembly being configured to contact and remain against the surface of the eye. Additionally, the device may include at least one active agent reservoir functionally associated with at least one of the anode assembly and the cathode assembly.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: June 17, 2014
    Assignee: Aciont, Inc.
    Inventors: John W. Higuchi, S. Kevin Li
  • Patent number: 8747856
    Abstract: The present invention relates to the use of a fully human antigen binding fragment of an antibody for the manufacture of a medicament for the treatment or diagnosis of an ocular disease upon topical administration. The invention further relates to a pharmaceutical composition comprising a fully human binding fragment of an antibody for ocular topical administration for treatment or diagnosis of an ocular disease. In particular, the antibody neutralizes HSV1 and HSV2.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: June 10, 2014
    Assignee: Ribovax Biotechnologies S.A.
    Inventors: Claire Abadie, Jean-Marc Combette, Catherine Deloche, Robert Anthony Williamson
  • Publication number: 20140148900
    Abstract: Intraocular devices having a drug delivery construct attached thereto, and methods for using the devices for intraocular drug delivery and the treatment and/or prevention of conditions.
    Type: Application
    Filed: December 20, 2013
    Publication date: May 29, 2014
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Buddy D. Ratner, Tueng T. Shen
  • Publication number: 20140148792
    Abstract: Devices and methods are provided for selectively delivering a drug by laser activation. The device includes structural elements forming a hermetic, enclosed reservoir, and at least one drug unit contained in the enclosed reservoir. The at least one drug unit includes a drug. The device is able to absorb laser irradiation effective to open the enclosed reservoir to permit release of the drug. The method includes implanting a drug delivery device into a tissue site of a patient, and irradiating at least a portion of the drug delivery device to breach the enclosed reservoir to permit the drug to be released in tissues at the tissue site.
    Type: Application
    Filed: February 3, 2014
    Publication date: May 29, 2014
    Applicant: On Demand Therapeutics Inc.
    Inventors: Jonathan R. Coppeta, Robert Dyer, Vipul Taneja, John T. Santini, JR.
  • Patent number: 8721622
    Abstract: A viscoelastic medium is useful for the manufacture of a medicament, such as a medical device, for treatment of increased intraocular pressure in the eye of a human or animal. The medicament is administerable into at least one sclerally penetrating fistula of the eye such that the fistula is filled with the medicament. The medium is also useful in a method of treating increased intraocular pressure in the eye of a human or an animal in need thereof, comprising the step of injecting the viscoelastic medium into at least one sclerally penetrating fistula in the eye such that the fistula is filled with the medium.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: May 13, 2014
    Assignee: Q-MED AB
    Inventor: Bengt Ågerup
  • Patent number: 8715220
    Abstract: Systems and methods for fluid control during aspiration. In an embodiment, an aspiration system includes an aspiration line having distal and proximal ends and an aspiration port defined in the distal end; a fluid transport device operatively coupled to the proximal end of the aspiration line; and a flow restrictor operatively coupled to the aspiration line in between the fluid transport device and the aspiration port. To measure occlusion within the line, first and second pressure sensors are utilized, the first sensor being operatively coupled to the aspiration line between the port and the restrictor and the second sensor being operatively coupled to the aspiration line between the restrictor and the fluid transport device. The pressure differential between the two sensors can provide an indication of the onset, presence, and/or elimination of an occlusion.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: May 6, 2014
    Assignee: Abbott Medical Optics Inc.
    Inventors: James Gerg, Carina R Reisin
  • Patent number: 8715266
    Abstract: Eye diseases such as glaucoma can be treated using a composition containing cross-linked hyaluronic acid or a cross-linked salt of hyaluronic acid such as sodium hyalurate. The composition can be a monophasic gel. The composition can include a cross-linking agent such as 1,4-butanediol diglycidylether. The composition can contains about 2.25% (w/w) of the salt of hyaluronic acid. The composition can have a cross-linking rate of about 0.5 to 50%.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: May 6, 2014
    Assignee: Aptissen SA
    Inventor: Gilles Bos
  • Patent number: 8679089
    Abstract: Methods and systems are disclosed for creating an aqueous flow pathway in the trabecular meshwork, juxtacanalicular trabecular meshwork and Schlemm's canal of an eye for reducing elevated intraocular pressure. Some embodiments described apparatus and methods useful in photoablation of tissues. In some embodiments, a photoablation apparatus is used to perforate a tissue, forming an aperture into a space behind the tissue. Gases formed during a photoablation process can be used to pressurize the space behind the tissue to enhance patency of the space. In some embodiments the tissue is the trabecular meshwork of the eye and a wall of Schlemm's canal, and the space behind the tissue is a portion of the lumen of Schlemm's canal. In some embodiments, the method is useful in the treatment of glaucoma by improving outflow from the anterior chamber of the eye into Schlemm's canal, reducing intraocular pressure.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: March 25, 2014
    Inventor: Michael S. Berlin
  • Patent number: 8668665
    Abstract: The invention is generally directed to systems and methods for fluid control, and more particularly to systems and methods for power and flow rate control for aspiration. In accordance with one embodiment, an aspiration system includes an aspiration line having distal and proximal ends and an aspiration port defined in the distal end; a fluid transport device operatively coupled to the proximal end of the aspiration line; and a flow restrictor operatively coupled to the aspiration line in between the fluid transport device and the aspiration port. To measure occlusion within the line, first and second pressure sensors are utilized, the first sensor being operatively coupled to the aspiration line between the port and the restrictor and the second sensor being operatively coupled to the aspiration line between the restrictor and the fluid transport device. The pressure differential between the two sensors can provide an indication of the onset, presence, and/or elimination of an occlusion.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: March 11, 2014
    Assignee: Abbott Medical Optics Inc.
    Inventors: James Gerg, Carina R Reisin
  • Patent number: 8663194
    Abstract: The present invention provides devices, systems, and methods for delivery of an active agent into the eye of a subject. In one aspect, for example, an ocular active agent delivery device (10) can include an active agent reservoir (14) disposed in an annular housing (12), the annular housing (12) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule. The device (10) can further include a semipermeable membrane (16) operatively coupled to the active agent reservoir (14), where the semipermeable membrane (16) is configured to allow diffusion of an active agent from the active agent reservoir (14). Additionally, a valve (18) can be operatively coupled to the active agent reservoir (14), where the valve (18) is configured to allow filling of the active agent reservoir (14) with an active agent.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: March 4, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Balamurali K. Ambati, Bruce K. Gale
  • Patent number: 8657804
    Abstract: The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. In particular, the present disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: February 25, 2014
    Assignee: On Demand Therapeutics, Inc.
    Inventors: Kenneth N. Horne, Gregory J. R. Spooner, John A. Scholl, John T. Santini, Jr.
  • Patent number: 8652086
    Abstract: The invention is generally directed to systems and methods for fluid control, and more particularly to systems and methods for power and flow rate control for aspiration. In accordance with one embodiment, an aspiration system includes an aspiration line having distal and proximal ends and an aspiration port defined in the distal end; a fluid transport device operatively coupled to the proximal end of the aspiration line; and a flow restrictor operatively coupled to the aspiration line in between the fluid transport device and the aspiration port. To measure occlusion within the line, first and second pressure sensors are utilized, the first sensor being operatively coupled to the aspiration line between the port and the restrictor and the second sensor being operatively coupled to the aspiration line between the restrictor and the fluid transport device. The pressure differential between the two sensors can provide an indication of the onset, presence, and/or elimination of an occlusion.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: February 18, 2014
    Assignee: Abbott Medical Optics Inc.
    Inventors: James Gerg, Carina Reisin
  • Patent number: 8652118
    Abstract: An agent delivery apparatus for administering a pharmacological agent formulation to a sub-mucosal compartment of a body organ, comprising injector means having an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein and an elongated agent delivery member having a first end that is in communication with the internal formulation chamber and a second ejection end, the injector means including force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from the injector means and into and through the agent delivery member, and out of the ejection end of the elongated agent delivery member. In one embodiment of the invention, the delivery member comprises a needleless delivery member.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: February 18, 2014
    Assignee: KMG Pharma, LLC
    Inventor: Gholam A. Peyman
  • Patent number: 8636713
    Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: January 28, 2014
    Assignees: Emory University, Georgia Tech Research Corporation
    Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
  • Patent number: 8634907
    Abstract: The present invention includes methods and devices for delivering an active agent into the eye of a subject. One such device may include an anode assembly having an anode housing and an anode configured to electrically couple to a power source, the anode assembly being configured to contact and remain against a surface of the eye. The device may also include a cathode assembly having a cathode housing and a cathode configured to electrically couple to the power source, the cathode assembly being configured to contact and remain against the surface of the eye. Additionally, the device may include at least one active agent reservoir functionally associated with at least one of the anode assembly and the cathode assembly.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: January 21, 2014
    Assignee: Aciont, Inc.
    Inventors: John W. Higuchi, S. Kevin Li
  • Publication number: 20130304031
    Abstract: A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.
    Type: Application
    Filed: July 15, 2013
    Publication date: November 14, 2013
    Inventors: Signe Erickson Varner, Eugene De Juan, Aaron Christopher Barnes, Terry Harrison Shelley, Michael J. Cooney
  • Patent number: 8580565
    Abstract: The present invention relates to a device and methods for culturing stem cells, and in particular, for culturing ocular stem cells and the use of stem cells cultured using the devices and methods of the invention for the treatment of diseases.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: November 12, 2013
    Inventor: Minas Theodore Coroneo
  • Patent number: 8574217
    Abstract: An agent delivery apparatus for administering a pharmacological agent formulation to a sub-mucosal compartment of a body organ, comprising injector means having an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein and an elongated agent delivery member having a first end that is in communication with the internal formulation chamber and a delivery nozzle end, the injector means including force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from the injector means and into and through the agent delivery member, and out of the delivery nozzle end of the elongated agent delivery member with a delivery pressure in the range of approximately 50-1000 psi.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: November 5, 2013
    Assignee: KMG Pharma, LLC
    Inventor: Gholam A. Peyman