Erythrocyte Patents (Class 604/6.02)
  • Patent number: 10722648
    Abstract: A surgical fluid management system includes a source of surgical media, a surgical instrument, a first pump, one or more filters, a second pump, and a controller. The first pump is operatively coupled between the source of surgical media and the surgical instrument. The one or more filters are configured to filter bodily discharge from a surgical site. The second pump is operatively coupled between the one or more filters and the first pump. The controller is in electrical communication with the first pump and the second pump to control the first and second pumps.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: July 28, 2020
    Assignee: Covidien LP
    Inventors: Kasey A. Grim, Joe D. Sartor, Valery E. Meusburger, Rachel C. Grosskrueger, Li-Mae H. McClellan, Fiona M. Wohlfarth, Ryan M. Wolsky
  • Patent number: 9169464
    Abstract: A method for isolating and processing bone marrow derived stem cells, including the steps of: (a) collecting a biological sample containing adherent bone marrow stem cells in a receptacle with interior walls coated with a cell-adherent substrate; (b) incubating the bone marrow cells on the adherent substrate so that a layer of adherent bone marrow stem cells adheres to the substrate; (c) washing any non-adherent cells from the substrate; and (d) collecting the bone marrow stem cell layer. Isolation kits and use of bone marrow cells harvested for cell therapies are also described.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: October 27, 2015
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Hatem Sabaawy
  • Patent number: 8871434
    Abstract: Synthetic aqueous storage solutions are disclosed for use in the processing and the storing of red blood cells prepared from whole blood including cells derived from whole blood held for an extended period at room temperature.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: October 28, 2014
    Assignee: Fenwal, Inc.
    Inventors: Véronique Mayaudon, Jean-Marc Payrat
  • Publication number: 20140148750
    Abstract: A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.
    Type: Application
    Filed: January 29, 2014
    Publication date: May 29, 2014
    Applicant: Haemonetics Corporation
    Inventors: Etienne Pagès, Michael Ragusa
  • Patent number: 8628489
    Abstract: A blood processing system for collecting and exchanging blood components includes a venous-access device for drawing whole blood from a subject and returning blood components to the subject. The system may also include three lines connecting the venous access device to a blood component separation device and an anticoagulant source. A blood draw line fluidly connects to the venous-access device to the blood component separation device. An anticoagulant line introduces anticoagulant into the drawn whole blood. A return line, fluidly connected to the venous-access device and the blood component separation device, and returns uncollected blood component to the subject. Each line may have a pump that controls flow through the line. The blood component separation device separates the drawn blood into a first blood component and a second blood component, and may be configured to send the first blood component to a first blood component bag.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: January 14, 2014
    Assignee: Haemonetics Corporation
    Inventors: Etienne Pagès, Michael Ragusa
  • Publication number: 20130267884
    Abstract: Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 10, 2013
    Applicant: FENWAL, INC.
    Inventors: Daniel R. Boggs, Kyungyoon Min, Lan T. Nguyen, John T. Foley, Brian Case
  • Patent number: 8470180
    Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: June 25, 2013
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Edward F. Leonard, Alan C. West, Christian Paul Aucoin, Edgar E. Nanne
  • Patent number: 8425448
    Abstract: This invention is directed to a method of collecting and separating whole blood into components. The method includes the steps of adding an anticoagulant having an acidic pH to a bag for collecting and/or separating whole blood, collecting whole blood in the bag, loading the bag containing anticoagulated whole blood on a rotor, spinning the bag on the rotor to separate the whole blood into at least one component; and squeezing the bag on the rotor to push the component from the separation bag into at least one satellite bag.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: April 23, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas Felt, Peter Pihlstedt, Bruce Gibbs
  • Patent number: 8277406
    Abstract: A method for separating a volume of whole blood contained in a separation bag into at least three components comprising centrifuging the separation bag so as to separate therein a first inner layer comprising plasma, a second intermediate layer comprising platelets, a third intermediate layer comprising lymphocytes, monocytes and granulocytes and a fourth outer layer comprising red blood cells, transferring, into a plasma component bag connected to the separation bag, a plasma component and transferring into a mononuclear cell component bag a mononuclear cell components.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: October 2, 2012
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas Felt, Brian M. Holmes, Bruce Gibbs
  • Patent number: 8257593
    Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: September 4, 2012
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Edward F. Leonard, Alan C. West, Christian Paul Aucoin, Edgar E. Nanne
  • Patent number: 8197432
    Abstract: A method for batch implementation of settings in a renal replacement therapy device including: displaying on a user interface control settings which may be manually selected by an operator; selecting an independent control setting of the plurality of control settings; adjusting the independent control setting to an independent control setting level selected by an operator; temporarily storing the adjusted independent control setting level; automatically adjusting a dependent control setting level based upon the independent control level; displaying the adjusted independent control setting level and the adjusted dependent control setting, and implementing both the adjusted independent control setting level and the adjusted dependent control setting to control the device, by actuating a batch setting acceptance operation.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: June 12, 2012
    Assignee: Gambro UF Solutions, Inc.
    Inventors: John J. O'Mahony, Thomas Robert Lendway, Andrew J. Halpert
  • Patent number: 8192386
    Abstract: Systems and methods for controlling hematocrit during a blood processing procedure. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the second and third flow paths to control fluid communication between the second and third flow paths and addition of separated plasma to the separated red blood cells. The resulting red blood cells and plasma has a resulting hematocrit. Hematocrit is calculated or sensed in operative association with the third flow path and communicated to the flow controller for controlling the amount of plasma added to the third flow path and the resulting hematocrit.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: June 5, 2012
    Assignee: Fenwal, Inc.
    Inventor: Kyungyoon Min
  • Patent number: 8163277
    Abstract: Kits are described for the treatment of acute or chronic dysfunction of cardiac muscle. The kit includes a platelet-rich plasma composition with a pH adjusting agent and a catheter or syringe for delivery of the platelet-rich plasma composition to dysfunctional cardiac muscle. The kit may also include a syringe for withdrawing blood from a patient and a centrifuge device to obtain platelet-rich plasma.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: April 24, 2012
    Inventor: Allan Mishra
  • Patent number: 8153083
    Abstract: This invention describes a method for pumping or delivering fluids utilizing a flexible vessel subject to controlled pressures within another pressure vessel. The pressure vessel can be sourced with positive and/or negative (e.g., vacuum) pressure.
    Type: Grant
    Filed: April 21, 2009
    Date of Patent: April 10, 2012
    Assignee: Therakos, Inc.
    Inventor: Dennis Briggs
  • Patent number: 8097162
    Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: January 17, 2012
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Edward F. Leonard, Alan C. West, Christian Paul Aucoin, Edgar E. Nanne
  • Patent number: 8097153
    Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: January 17, 2012
    Assignee: The Trustees of Columbia in the City of New York
    Inventors: Edward F. Leonard, Alan C. West, Christian Paul Aucoin, Edgar E. Nanne
  • Patent number: 8092684
    Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: January 10, 2012
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Edward F. Leonard, Alan C. West, Christian Paul Aucoin, Edgar E. Nanne
  • Patent number: 8083706
    Abstract: The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: December 27, 2011
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Edward F. Leonard, Alan C. West, Nina C. Shapley, Zhongliang Tang
  • Publication number: 20110178453
    Abstract: A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.
    Type: Application
    Filed: March 31, 2011
    Publication date: July 21, 2011
    Applicant: HAEMONETICS CORPORATION
    Inventors: Etienne Pagès, Michael Ragusa
  • Publication number: 20110152740
    Abstract: A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. After red blood cells have been collected, an unwanted blood component, e.g., buffy coat, is diverted into the red blood cell collect line. Operation of a peristaltic pump engaging pump loop allows insertion of a pre-determined quantity of buffy coat into the collect line. The buffy coat can therefore push red blood cells out of the filter and into a collect bag without diluting the collected red blood cells. Alternatively, gravitational force may be used to allow the unwanted blood component to displace red blood cells out of the filter.
    Type: Application
    Filed: December 8, 2010
    Publication date: June 23, 2011
    Applicant: CARIDIANBCT, INC.
    Inventor: Bruce W. GIBBS
  • Patent number: 7833185
    Abstract: A method and apparatus for separating a volume of whole blood contained in a separation bag into at least three components comprising centrifuging the separation bag so as to separate therein a first inner layer comprising plasma, a second intermediate layer comprising platelets, a third intermediate layer comprising lymphocytes, monocytes and granulocytes and a fourth outer layer comprising red blood cells, transferring, into a plasma component bag connected to the separation bag, a plasma component and transferring into a mononuclear cell component bag a mononuclear cell components.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: November 16, 2010
    Assignee: CaridianBCT, Inc.
    Inventors: Thomas Felt, Brian M. Holmes, Bruce Gibbs
  • Patent number: 7789847
    Abstract: A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures involve filtering the separated red blood cells in a diluted state after and/or prior to flushing the filter with storage solution. Storage solution may thus be passed through the leukoreduction filter before, with and/or after the RBCs have been filtered therethrough. The red blood cell collection, filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: September 7, 2010
    Assignee: CaridianBCT, Inc.
    Inventors: Bruce W. Gibbs, Jon Herskovits
  • Patent number: 7727399
    Abstract: A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.
    Type: Grant
    Filed: May 22, 2007
    Date of Patent: June 1, 2010
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Edward F. Leonard, Alan C. West, Christian P. Aucoin, Edgar E. Nanne
  • Patent number: 7708710
    Abstract: Methods are disclosed for collecting and separating whole blood into one or more components. A disposable blood separation fluid circuit is provided which is adapted to cooperate with a reusable separation controller. The fluid circuit includes a fluid flow path for communication with a blood source and at least one container in fluid communication with the fluid flow path. The fluid flow path is connected to a blood source and quantities of whole blood are collected in the container and one other location within the fluid circuit. The source is then disconnected from the disposable fluid circuit. The quantities of whole blood are centrifugally processed, with processing of at least a portion of one of the quantities beginning after the source is disconnected from the fluid circuit.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: May 4, 2010
    Assignee: Fenwal, Inc.
    Inventors: Kyungyoon Min, Richard I. Brown
  • Patent number: 7686777
    Abstract: An in-vitro blood plasma lipids filtering method includes the following steps: separating out the blood plasma from the blood collection; flushing a filtering device with saline solution; controlling the pressure of the separated blood plasma; passing the blood plasma to the filtering device for filtering out lipids; controlling the temperature of the filtered blood plasma; and feeding the blood plasma back to the blood. The method is clearly effective and accurate, quick response indication, securer and safer, more tolerant, and the treatment time is short.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: March 30, 2010
    Assignee: Shanghai Jiangxia Blood Technology Co., Ltd.
    Inventors: Heping Huang, Siukwan Chang
  • Patent number: 7686779
    Abstract: A preconnected disposable and method for red blood collection is provided wherein the preconnected disposable includes a red blood cell collection assembly comprising a leukoreduction filter and a red blood cell storage bag. Such a red blood cell collection assembly is preferably preconnected to a blood component separation vessel, cassette assembly and a blood removal/return assembly for removing blood from a donor, separating the blood into components for collection and providing for filtration of the separated red blood cell component.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: March 30, 2010
    Assignee: Caridian BCT, Inc
    Inventor: Bruce W. Gibbs
  • Patent number: 7682329
    Abstract: A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures involve filtering the separated red blood cells in a diluted state after and/or prior to flushing the filter with storage solution. Storage solution may thus be passed through the leukoreduction filter before, with and/or after the RBCs have been filtered therethrough. The red blood cell collection, filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component.
    Type: Grant
    Filed: April 6, 2006
    Date of Patent: March 23, 2010
    Assignee: CaridianBCT, Inc.
    Inventors: Bruce W. Gibbs, Jon Herskovits
  • Publication number: 20090259163
    Abstract: A blood processing system for collecting and exchanging blood components includes a venous-access device for drawing whole blood from a subject and returning blood components to the subject. The system may also include three lines connecting the venous access device to a blood component separation device and an anticoagulant source. A blood draw line fluidly connects to the venous-access device to the blood component separation device. An anticoagulant line connected to an anticoagulant source, introduces anticoagulant into the drawn whole blood. A return line, fluidly connected to the venous-access device and the blood component separation device, and returns uncollected blood component to the subject. A draw pump, an anticoagulant pump, and a return pump, respectively control the flows through the draw line, anticoagulant line, and the return line. The blood component separation device separates the drawn blood into a first blood component and a second blood component.
    Type: Application
    Filed: April 14, 2008
    Publication date: October 15, 2009
    Inventors: Etienne Pages, Michael Ragusa
  • Publication number: 20090209898
    Abstract: This invention describes a method for pumping or delivering fluids utilizing a flexible vessel subject to controlled pressures within another pressure vessel. The pressure vessel can be sourced with positive and/or negative (e.g., vacuum) pressure.
    Type: Application
    Filed: April 21, 2009
    Publication date: August 20, 2009
    Applicant: THERAKOS, INC.
    Inventor: Dennis A. Briggs
  • Patent number: 7534221
    Abstract: Endovascular intervention methods entail creating a temporary capillary block in the vasculature of at least a portion of a patient's organ, such as a hemisphere of the patient's brain, the capillary block essentially blocking blood flow through capillaries in the portion of the patient's organ, and performing the endovascular intervention. Distal embolism protection devices include a blood pump and at least one of a centrifuge element, a dialysis element, a cooling element, and a filtration element. The blood pump is generally capable of drawing blood from a patient's vein, circulating the blood through each of the elements so that a characteristic of a blood component may be manipulated therewith, and perfusing the modified blood into a patient's artery. A capillary block is thereby created in the vasculature of at least a portion of a patient's organ with manipulated blood components.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: May 19, 2009
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: John Pile-Spellman
  • Patent number: 7534616
    Abstract: This invention describes a method for pumping or delivering fluids utilizing a flexible vessel subject to controlled pressures within another pressure vessel. The pressure vessel can be sourced with positive and/or negative (e.g., vacuum) pressure.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: May 19, 2009
    Assignee: Therakos, Inc.
    Inventor: Dennis A. Briggs
  • Patent number: 7517333
    Abstract: Systems and methods separate pump the blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter has a filtration medium enclosed within a flexile housing. The systems and methods can employ a fixture to restrain expansion of the flexible filter housing during operation of the pump.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: April 14, 2009
    Assignee: Baxter International Inc.
    Inventors: Mark R Vandlik, Michael J Kast, Kelly B Smith, Tom Westberg, Rohit Vishnoi
  • Publication number: 20090043237
    Abstract: Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.
    Type: Application
    Filed: August 7, 2008
    Publication date: February 12, 2009
    Applicant: CaridianBCT, Inc.
    Inventors: Robert W. Langley, Thomas J. Felt, Geert Van Waeg, Marlene Adele Bainbridge
  • Publication number: 20080200859
    Abstract: A system for separating fluid components comprising a sealless rotating drum, a rotatable disposable centrifuge cartridge within the drum, a multi-lumen tube fluidly connectable to the cartridge and to an external fluid source, and a control system capable of independently controlling the flow rate within each lumen of the multi-lumen tube. This system may also be used in apheresis procedures for separating blood components from whole blood. The multi-lumen tube may have a ribbon section that unidirectionally fits within a peristaltic block of rollers, wherein each lumen's flow rate may be individually controlled. The system may further include a camera unit operable to observe a separation boundary within the centrifuge cartridge and accordingly adjust the rotation speed to increase or decrease the amount of separation.
    Type: Application
    Filed: February 15, 2007
    Publication date: August 21, 2008
    Inventors: Mehdi Hatamian, Matthew Douglas McCawley, Toshi Ghalebi, Matin Ebneshahrashoob
  • Patent number: 7303540
    Abstract: A graphical user interface (GUI) for medical instruments for a Renal Replacement Therapy that enables an operator to select and review a series of settings for an extracorporeal pump console and implement the settings in batch manner. The GUI automatically adjusts or recommends dependent settings, e.g. filtration rate, as the user adjusts primary settings, e.g. blood flow rate.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: December 4, 2007
    Assignee: CHF Solutions, Inc.
    Inventors: John J. O'Mahony, Thomas Robert Lendway, Andrew J. Halpert
  • Publication number: 20070179423
    Abstract: This invention is directed to a method of collecting and separating whole blood into components. The method includes the steps of adding an anticoagulant having an acidic pH to a bag for collecting and/or separating whole blood, collecting whole blood in the bag, loading the bag containing anticoagulated whole blood on a rotor, spinning the bag on the rotor to separate the whole blood into at least one component; and squeezing the bag on the rotor to push the component from the separation bag into at least one satellite bag.
    Type: Application
    Filed: January 30, 2007
    Publication date: August 2, 2007
    Applicant: GAMBRO BCT, INC.
    Inventors: Thomas FELT, Bruce GIBBS, Peter PIHLSTEDT
  • Patent number: 7195606
    Abstract: The invention provides a syringe for preventing anemia resulting from withdrawal of blood from a patient for analysis, the syringe including a cylindrical tube having a nozzle at its lower end to which a needle is attachable; a piston disposed within the tube and apiston handle protruding from the upper end of hte tube; the syringe being further adapted to a be placed in a centrifuge for separating blood drawn from the patient into supernatant plasma component and a packed-cells component, and further comprising means for separating or removing at least a portion of teh plasma, thereby facilitating the injection of the packed-cells back into the patient The invention also provides a method for preventing anemia resulting from the withdrawal of blood from a patient for analysis.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: March 27, 2007
    Assignee: ErythroSave Ltd.
    Inventor: Ben-Ami Ballin
  • Patent number: 7182865
    Abstract: Method for separating whole blood into a leukocyte-depleted erythrocyte concentrate and thrombocyte-containing plasma, in which method whole blood is separated in a first step into an erythrocyte concentrate and plasma in a plasma filter and is then separated into a second erythrocyte concentrate and more thrombocyte-containing plasma during the return flow through the same plasma filter, the erythrocyte concentrate obtained being mixed with an additive solution, and the entire separation system being closed on itself and sterile.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: February 27, 2007
    Inventor: Sibylle Latza
  • Patent number: 7169547
    Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: January 30, 2007
    Assignee: New York Blood Center, Inc.
    Inventors: Pablo Rubinstein, Philip Henry Coelho, Cladd E. Stevens
  • Patent number: 7115205
    Abstract: A system for automatically collecting and separating whole blood into its components is described. The system includes a console, which contains all motors, pumps, sensors, valves and control circuitry, and a unique disposable set that includes a cassette supporting a centrifuge with an improved design, pump interfaces with an improved design, component and solution bags, and tubing. Various processes are implemented using a specific disposable set for each process which allows automatic identification of the process to be performed the console.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: October 3, 2006
    Assignee: Mission Medical, Inc.
    Inventors: Thomas C. Robinson, Thomas P. Robinson, Richard D'Elia, Thomas Sahines, Paul Eibe
  • Patent number: 7108672
    Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing channel and the utilization of high packing factors for the procedure.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: September 19, 2006
    Assignee: Gambro Inc
    Inventors: Chad C Steele, Marlene Adele Bainbridge, Denise C Garrison, Terry R Wahl
  • Patent number: 7037428
    Abstract: A system for automatically processing blood components is described. The system includes a console, which contains all motors, pumps, sensors, valves and control circuitry, and a unique disposable set that includes a cassette supporting a centrifuge with an improved design, pump interfaces with an improved design, component and solution bags, and tubing. Various processes are implemented using a specific disposable set for each process which allows automatic identification of the process to be performed the console.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: May 2, 2006
    Assignee: Mission Medical, Inc.
    Inventors: Thomas C. Robinson, Thomas P. Robinson, Richard D'Elia, Paul Eibe, Thomas Sahines
  • Patent number: 6902539
    Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: June 7, 2005
    Assignee: GamBro Inc
    Inventors: Marlene Adele Bainbridge, Brian M. Holmes
  • Patent number: 6893412
    Abstract: A platelet collecting apparatus 1 comprises a centrifugal separator 20 possessing a rotatable rotor 142; a first line 21 for allowing the flow of the blood entering the centrifugal separator 20; a second line 22 for allowing the flow of the blood emanating from the centrifugal separator, a plasma collecting bag 25 connected to the first line 21 and the second line 22 so as to collect the plasma emanating from the centrifugal separator 20 and return the collected plasma to the centrifugal separator 20, a platelet collecting bag 26 connected to the second line 22 so as to collect the platelets emanating from the centrifugal separator 20, a blood delivering pump 11 disposed in the first line 21, and a controller 13 for controlling the operation of the rotor of the centrifugal separator 20 and the operation of the blood delivering pump 11.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: May 17, 2005
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Noboru Saito, Takeshi Udagawa, Kunio Horiuchi
  • Patent number: 6855119
    Abstract: A blood separation system is fully mechanized to collect blood from a patient, separate waste portions of the blood, wash the blood, and redirect the usable portions to a device for reinjecting the usable portions into the patient. The system provides screen displays with detailed setup instructions and instructs the operator at the appropriate times to do certain manual steps. Apparatus for sequestration of platelet rich plasma spins at a high speed sufficient to separate solid cells from the blood sample and then spins at a lower speed for a predetermined time to allow platelets to elute from the solid cells.
    Type: Grant
    Filed: July 8, 2002
    Date of Patent: February 15, 2005
    Assignee: Medtronic, Inc.
    Inventors: John Rivera, Son Le, Daniel Cheek, Richard Matt, Roger P. Kaminski
  • Publication number: 20040254515
    Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis sytem in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing channel and the utilization of high packing factors for the procedure.
    Type: Application
    Filed: August 6, 2004
    Publication date: December 16, 2004
    Applicant: GAMBRO, INC.
    Inventors: Chad C. Steele, Marlene Adele Bainbridge, Denise C. Garrison, Terry R. Wahl
  • Patent number: 6790195
    Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis sytem in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing channel and the utilization of high packing factors for the procedure.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: September 14, 2004
    Assignee: Gambro Inc
    Inventors: Chad C. Steele, Marlene Adele Bainbridge, Denise C. Garrison, Terry R. Wahl
  • Publication number: 20040156745
    Abstract: Systems and methods separate pump the blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter has a filtration medium enclosed within a flexile housing. The systems and methods can employ a fixture to restrain expansion of the flexible filter housing during operation of the pump.
    Type: Application
    Filed: January 26, 2004
    Publication date: August 12, 2004
    Applicant: Baxter International Inc.
    Inventors: Mark R. Vandlik, Michael J. Kast, Kelly B. Smith
  • Patent number: 6773413
    Abstract: An extracorporeal blood processing method includes a set-up phase establishing certain conditions in blood being processed prior to separation of the blood into components. Also, a blood processing method contemporaneously extracts selected multiple blood components from a blood processing vessel. Blood is separated into components in the blood processing vessel in a centrifugal field. Further, an extracorporeal blood processing method establishes a packing factor in the blood processing vessel prior to collecting red blood cells.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: August 10, 2004
    Assignee: Gamero Inc
    Inventors: Muriel Keller, Marlene Bainbridge
  • Patent number: 6709412
    Abstract: Systems and methods separate blood cells from whole blood and pump the separated blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter has a filtration medium enclosed within a flexile housing. The systems and methods employ a fixture to restrain expansion of the flexible filter housing during operation of the pump. The fixture has a bracket to enable its releasable attachment to the blood processing device employed to carry out the separation process.
    Type: Grant
    Filed: October 13, 2001
    Date of Patent: March 23, 2004
    Assignee: Baxter International Inc.
    Inventors: Mark Vandlik, Michael J Kast, Kelly B Smith