Component Of Blood Removed (i.e., Pheresis) Patents (Class 604/6.01)
  • Patent number: 10980837
    Abstract: The present disclosure is drawn to compositions and methods of making and using lyophilized platelet lysates. Specifically, a method of preparing a composition suitable for therapeutic use or as a culture medium can comprise steps of concentrating platelets from a platelet source to form a platelet rich portion of the platelet source, and lysing the platelets in the platelet rich portion to form a plurality of lysates. An additional step includes lyophilizing the lysates to form lyophilized platelet lysates in a composition with released concentrations of available growth factors, cytokines, and chemokines. In one example, at 30%, by platelet count, of platelets from a platelet source can be lysed using this process.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: April 20, 2021
    Assignee: Jadi Ceil LLC
    Inventor: Amit Patel
  • Patent number: 10960128
    Abstract: A biological component collection system and a circuit internal pressure acquisition method are provided, which are capable of accurately measuring the circuit internal pressure. A centrifugal separation device of a blood component collection system has a first load detecting unit, an internal pressure calculation unit that calculates an internal pressure using the load detected by the first load detecting unit and internal pressure calculation data. The internal pressure calculation unit performs a calculation reflecting a change in the internal pressure calculation data depending on temperature.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: March 30, 2021
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Masatsugu Igarashi, Davis Benz
  • Patent number: 10953149
    Abstract: Methods (300), devices, and systems of processing blood are described. The method (300) comprises the steps of: obtaining (312) blood from a patient coupled to a single blood processing device to form a closed loop between the patient and the blood processing device; collecting (314) bulk mononuclear blood cells from the blood by leukapheresis implemented using the blood processing device in the closed loop; and enriching (316) concurrently target cells separated from non-target cells in the bulk mononuclear blood cells using the blood processing device in the closed loop.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: March 23, 2021
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: David Peritt, Philip Wong, Janet Lesley Macpherson, Kevin Henrichsen, Geoffrey Phillip Symonds, Susan Pond
  • Patent number: 10940259
    Abstract: Methods (300), devices, and systems of processing blood are described. The method (300) comprises the steps of: obtaining (312) blood from a patient coupled to a single blood processing device to form a closed loop between the patient and the blood processing device; collecting (314) bulk mononuclear blood cells from the blood by leukapheresis implemented using the blood processing device in the closed loop; and enriching (316) concurrently target cells separated from non-target cells in the bulk mononuclear blood cells using the blood processing device in the closed loop.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: March 9, 2021
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: David Peritt, Philip Wong, Janet Lesley Macpherson, Kevin Henrichsen, Geoffrey Phillip Symonds, Susan Pond
  • Patent number: 10926020
    Abstract: Methods (300), devices, and systems of processing blood are described. The method (300) comprises the steps of: obtaining (312) blood from a patient coupled to a single blood processing device to form a closed loop between the patient and the blood processing device; collecting (314) bulk mononuclear blood cells from the blood by leukapheresis implemented using the blood processing device in the closed loop; and enriching (316) concurrently target cells separated from non-target cells in the bulk mononuclear blood cells using the blood processing device in the closed loop.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: February 23, 2021
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: David Peritt, Philip Wong, Janet Lesley Macpherson, Kevin Henrichsen, Geoffrey Phillip Symonds, Susan Pond
  • Patent number: 10919049
    Abstract: Mid-procedure termination of a mononuclear cell collection procedure may prevent collection of an amount of red blood cells that is required to harvest a complete mononuclear cell product. Blood separation systems and methods are provided for minimizing the impact of or recovering from mid-procedure termination of such a mononuclear cell collection procedure. According to one approach, blood or separated red blood cells are conveyed into a red blood cell collection container relatively early in the procedure to minimize the impact of a later termination of the procedure. According to another approach, blood and/or separated red blood cells within a fluid processing assembly are redirected through the fluid processing assembly following mid-procedure termination to allow for at least partial mononuclear cell collection.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: February 16, 2021
    Assignee: Fenwal, Inc.
    Inventors: Lan T. Nguyen, Zahra R. Ali, Angela N. Carlson, Korri Hershenhouse, Molly Erickson
  • Patent number: 10857269
    Abstract: A fluid processing system for controlling fluid flow comprising a cassette comprising defined passageways within a first portion of the cassette and a filter receptacle within a second portion of the cassette, an inlet port in communication with one or more of the defined passageways and an inlet side of the filter receptacle, an outlet port in communication with an outlet side of the filter receptacle, and a filter medium disposed within the filter receptacle between the inlet port and outlet port.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: December 8, 2020
    Assignee: Fenwal, Inc.
    Inventors: David S. Brown, Carlos Calderon
  • Patent number: 10835755
    Abstract: The present invention is related to novel functional antibody coated nanoparticles, and the preparation method thereof. The functional antibody coated nanoparticles according to the present invention can be used as photothermal agents to effectively inhibit the growth of microbes including drug-resistant strains and biolfilm with laser irradiation.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: November 17, 2020
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: Nancy J. Millenbaugh, Mauris DeSilva, Jonathan Baskin, William R Elliot
  • Patent number: 10773013
    Abstract: A blood component collection system (10) includes a first internal pressure calculation unit (110) adapted to calculate a first internal pressure of a first pressed portion (60) using first calibration curve data (118), a second internal pressure calculation unit (112) adapted to calculate a second internal pressure of a second pressed portion (62) using second calibration curve data (120), and a correction unit (114) adapted to correct the first calibration curve data (118) in a manner so that, during a blood returning operation, the first internal pressure calculated by the first internal pressure calculation unit (110) becomes equal to the second internal pressure calculated by the second internal pressure calculation unit (112).
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: September 15, 2020
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Masatsugu Igarashi
  • Patent number: 10682611
    Abstract: A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: June 16, 2020
    Assignee: Fenwal, Inc.
    Inventors: Richard I. Brown, Benjamin E. Kusters, Kyungyoon Min
  • Patent number: 10426886
    Abstract: The object of the invention is to provide a blood separation device that can reduce the total time for drawing blood to obtain high-concentration platelet liquid, thereby reducing the binding time of the blood donor. The device includes a temporary storage bag (Y2) (also serves as a buffy coat bag) which is a whole blood bag for storing whole blood drawn from a blood donor. The controlling unit of the device controls the device to draw whole blood from the blood donor in parallel with at least either a circulation flow step or an acceleration step, thereby storing the drawn whole blood in the temporary storage bag (Y2).
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: October 1, 2019
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Shigeyuki Kimura, Takemi Kobayashi
  • Patent number: 10329530
    Abstract: A fluid circuit for cell washing is provided that comprises a spinning membrane separator and a fluid management system comprising a cassette that defines the fluid pathways, and including internally mechanical valving, pressure sensing and air sensing for controlling flow through the fluid pathways, thus minimizing the volume of the fluid circuit. Additionally, the fluid circuit comprises syringes that are acted on by syringe pumps associated with the hardware component of the system to provide pressure for moving fluid through the circuit. Preferably, the syringes are connected directly to the cassette, or formed integrally within the cassette housing, thus further minimizing the volume of the fluid circuit.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: June 25, 2019
    Assignee: Fenwal, Inc.
    Inventor: Christopher J. Wegener
  • Patent number: 10220132
    Abstract: Apparatus, system and method are provided for controlling flow through a biological fluid processing device. Pressure of fluid flow through a flow path is monitored and flow rate in the flow path is increased or decreased based on sensed pressure levels for selected periods of time. This has particular application in controlling flow in an infusion or return flow path of an apheresis device that separates whole blood into one or more blood components.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: March 5, 2019
    Assignee: Fenwal, Inc.
    Inventors: Amit J. Patel, Samantha M. Planas, Kathleen M. Higginson, Melissa A. Thill, Courtney Moore
  • Patent number: 10124113
    Abstract: Apparatus are provided for infusion devices and related operating methods. An exemplary device includes a sensing arrangement to provide an output indicative of a characteristic that is influenced by operation of the device, and a control module that is coupled to the sensing arrangement to apply a matched filter corresponding to a condition associated with the operation of the device to the output of the sensing arrangement and detect that condition based on the filtered output. In one example, the device includes a motor coupled to a plunger of a reservoir and operable to displace the plunger, wherein the characteristic is a force opposing displacement of the plunger and the control module detects an occlusion condition in a fluid path from the reservoir based on filtered force measurements.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: November 13, 2018
    Assignee: Medtronic MiniMed, Inc.
    Inventors: R. Marie Tieck, Juan M. Alderete, Jr., Matthew I. Haller
  • Patent number: 10039877
    Abstract: Methods and systems for obtaining platelets are disclosed. Platelets are collected in a pre-determined volume of plasma and a determined amount of a combined storage medium including the pre-determined amount of plasma and a volume of a synthetic additive solution.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: August 7, 2018
    Assignee: FENWAL, INC.
    Inventors: Katherine Radwanski, Kyungyoon Min
  • Patent number: 9987411
    Abstract: Methods and systems for priming biological fluid processing systems are disclosed. In accordance with such methods and systems, the disposable fluid processing circuit is primed by introducing a first priming solution into a portion of the circuit and a second priming solution into a portion of the circuit. The amount of citrate returned to the biological flood source is minimized.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: June 5, 2018
    Assignee: FENWAL, INC.
    Inventors: Samantha M. Planas, Amit J. Patel, Melissa A. Thill, Christopher Wegener, Elizabeth Asma
  • Patent number: 9669152
    Abstract: Provided is a blood component separation device that can shorten the overall time to collect high-concentration platelet liquid for blood component donation, thereby reducing time to keep a donor for blood drawing. The blood component separation device includes a temporary storage bag (also used as a buffy coat bag) which is also used as a whole blood bag for storing whole blood drawn from the donor. A control means performs whole blood drawing from the donor in parallel with performing at least either of a circulation flow step and an acceleration step, thereby storing the collected whole blood in the temporary storage bag.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: June 6, 2017
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Shigeyuki Kimura, Ryoji Kataoka
  • Patent number: 9474679
    Abstract: A system and method for performing tissue therapy may include applying a reduced pressure to a tissue site, sensing a fluid parameter being applied to the tissue site, generating a fluid sensor signal in response to sensing the fluid parameter, and altering the fluid sensor signal in response to sensing that the fluid parameter changes. A fluid leak location mode may be entered. In response to the fluid leak location mode being entered, a graphical user interface that provides for fluid leak location functionality may be displayed. In one embodiment, the fluid leak location mode may be automatically entered in response to the sensor signal crossing a threshold value. Additionally, an alarm signal may be generated in response to determining that the fluid sensor signal crosses the threshold value.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: October 25, 2016
    Assignee: KCI Licensing, Inc.
    Inventors: Christopher Brian Locke, Mark Stephen James Beard, David Robson Blandford, Timothy Mark Robinson
  • Patent number: 9402949
    Abstract: Apparatus are provided for infusion devices and related operating methods. An exemplary device includes a sensing arrangement to provide an output indicative of a characteristic that is influenced by operation of the device, and a control module that is coupled to the sensing arrangement to apply a matched filter corresponding to a condition associated with the operation of the device to the output of the sensing arrangement and detect that condition based on the filtered output. In one example, the device includes a motor coupled to a plunger of a reservoir and operable to displace the plunger, wherein the characteristic is a force opposing displacement of the plunger and the control module detects an occlusion condition in a fluid path from the reservoir based on filtered force measurements.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: August 2, 2016
    Assignee: Medtronic MiniMed, Inc.
    Inventors: R. Marie Tieck, Juan M. Alderete, Jr., Matthew I. Haller
  • Patent number: 9302041
    Abstract: A blood-donation system and methods of usage are disclosed. The system includes a blood-donating chair configured to interoperate with various blood-processing apparatuses. The system further combines into a self-contained system all devices, communications pathways and power supplies for various powered devices employed during a blood-collecting session. The system may further interoperate with other blood-donation systems allowing for continuous monitoring of multiple blood-collecting sessions at a single user interface. According to another embodiment, in addition to interoperability, the system is further configured for upgradability, in which, various donor-station devices may be mounted and remounted.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: April 5, 2016
    Assignee: Haemonetics Corporation
    Inventor: Gary R. Stacey
  • Patent number: 9279104
    Abstract: A blood processing system and method are disclosed that comprise a leukoreduction filter for removing leukocytes from red blood cells as the red blood cells pass through the filter; and a pump for pumping an additive solution through the leukoreduction filter to flush the leukoreduction filter of red blood cells that remain in the leukoreduction filter after filtration of the red blood cells. Additive solution is flowed through the leukoreduction filter at an initial flush rate to flush remaining red blood cells from the leukoreduction filter and the pump increases the flush rate of the additive solution during flushing of the leukoreduction filter.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: March 8, 2016
    Assignee: Fenwal, Inc.
    Inventors: Benjamin Kusters, Christopher Wegener, Kyungyoon Min
  • Patent number: 9173990
    Abstract: A method is provided in a centrifugal blood processing system for adding replacement fluid without a dedicated peristaltic pump to blood components being returned to the donor. A disposable blood processing set for use in the method comprises a hermetically sealed set of blood bags, connecting tubes, needles or connectors, and supporting structures with a replacement fluid line coupled directly to a return reservoir without contact with an intervening pump.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: November 3, 2015
    Assignee: Terumo BCT, Inc.
    Inventors: John R. Lindner, William Sweat
  • Patent number: 9171368
    Abstract: A variation of a method for estimating a quantity of a blood component in a fluid canister includes: within an image of a canister, identifying a reference marker on the canister; selecting an area of the image based on the reference marker; correlating a portion of the selected area with a fluid level within the canister; estimating a volume of fluid within the canister based on the fluid level; extracting a feature from the selected area; correlating the extracted featured with a concentration of a blood component within the canister; and estimating a quantity of the blood component within the canister based on the estimated volume and the concentration of the blood component within the canister.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: October 27, 2015
    Assignee: Gauss Surgical
    Inventors: Siddarth Satish, Ali Zandifar, Kevin J Miller
  • Patent number: 9011769
    Abstract: A blood reservoir may be used in combination with other elements such as a heart lung machine (HLM), oxygenator, heat exchanger, arterial filter and the like to form an extracorporeal blood circuit that may be employed in a procedure such as a bypass procedure. The blood reservoir may be configured to receive, filter and store blood from a number of sources including vent blood (from within the heart), venous blood (from a major vein), purge blood (from a sampling line) and cardiotomy or suction blood (from the surgical field).
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: April 21, 2015
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Claudio Silvestri, Gabriele Tommasi
  • Patent number: 9005343
    Abstract: A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: April 14, 2015
    Assignee: New Health Sciences, Inc.
    Inventors: Tatsuro Yoshida, Paul J. Vernucci
  • Patent number: 8986237
    Abstract: A filtering unit for removing a virucidal substance from a biological fluid including an outer casing having at least one input aperture and at least one output aperture. The outer casing including a filter medium, which separates the filtration unit into an input compartment and an output compartment. The filter medium includes at least one hydrophilic material able to absorb or adsorb the virucidal substance. The at least one hydrophilic material includes either porous non-woven material or a porous membrane.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: March 24, 2015
    Assignee: Macopharma
    Inventors: Francis Goudaliez, Thierry Verpoort
  • Patent number: 8979787
    Abstract: This invention uses “targeted apheresis” to treat pregnant women who are at risk of developing eclampsia. “Targeted Apheresis” is a process whereby certain growth factor receptors (sFlt-1) circulating in the blood of a pregnant woman at risk of developing pre-eclampsia are selectively removed by passing the blood through a cartridge containing immobilized anti-sFlt-1 aptamers. The circulating sFlt-1 is bound out by the immobilized anti-sFlt-1 aptamers and the cleaned blood is returned to the patient. Removal of circulating sFlt-1 will diminish the risk of developing eclampsia during pregnancy.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: March 17, 2015
    Inventors: Henry John Smith, James Roger Smith
  • Patent number: 8961445
    Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: February 24, 2015
    Assignee: Biomet Biologics, LLC
    Inventors: Douglas M. Arm, Michael Ponticiello, Surinder Mathur, Andrew G. Hood
  • Patent number: 8959617
    Abstract: Systems, methods, apparatus, and computer readable media are provided for disposable component authentication with respect to a biological fluid processing device instrument. An example instrument authentication system includes a computer facilitating configuration and operation of the biological fluid processing instrument using a disposable component. A first interface is provided by the computer and is used by a service technician to configure the biological fluid processing instrument for a number of disposable components and to provide a service technician with a validation code. A key generator is to accept the validation code from the service technician and generate an authentication key in response to the entered validation code. A second interface is provided by the computer, the second interface prompting the service technician to enter an authentication key, wherein the authentication key authorizes use of a certain number of disposable components for the biological fluid processing instrument.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 17, 2015
    Assignee: Fenwal, Inc
    Inventors: Douglas Newlin, Kevin Krause, Robert Crampton, John T. Foley, Brian Case, William Cork
  • Patent number: 8945037
    Abstract: A blood purification apparatus has a dialyzer (1), an arterial blood circuit (2) with a blood pump 4, a venous blood circuit 3, a dialysate introduction line L1, a dialysate discharge line L2, a substitution line L3, and a substitution pump 9 that supplies the dialysate flowing in the substitution line L3 to the arterial blood circuit 2. A control device (11) estimates or measures the concentration of blood in a dilution channel section A. The control device (11) controls the volume of dialysate supplied by the substitution pump 9 on the basis of the estimated or measured blood concentration.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: February 3, 2015
    Assignee: Nikkiso Company Limited
    Inventors: Shinya Hasegawa, Masahiro Toyoda
  • Patent number: 8932469
    Abstract: A dialysis machine includes a blood circuit, a dialysate circuit, and a dialyzer placed in communication with the blood circuit and the dialysate circuit. The dialysis machine includes a priming sequence in which dialysate is used to prime a first portion of the dialysate circuit and a physiologically compatible solution, other than dialysate, is used to prime a second portion of the dialysate circuit, the dialyzer and the blood circuit.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: January 13, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Robert W. Childers, Thomas D. Kelly, Rodolfo Roger
  • Patent number: 8926543
    Abstract: The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: January 6, 2015
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Kazuhide Ohta, Hiroshi Miyamoto, Junji Takaba, Ako Nosé
  • Patent number: 8911390
    Abstract: The present invention concerns a multipart fluid system for use in CRRT, wherein the multipart fluid system comprises an anticoagulation fluid and at least one fluid from the group consisting of a dialysis fluid and an infusion fluid. According to the invention the anticoagulation fluid comprises at least 8 mM citrate, and the dialysis fluid and/or infusion fluid comprises 2-8 mM citrate and 1-5 mM total calcium. The present invention further concerns a system for regional citrate anticoagulation in an extracorporeal blood circuit.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: December 16, 2014
    Assignee: Gambro Lundia AB
    Inventor: Jan Sternby
  • Patent number: 8905960
    Abstract: A device for the filtration of a complex fluid composition such as blood, includes a base (12) with a bottom (18), a top (14) with a bottom (30), and a membrane (16) that is arranged between the base and the top so as to define a low chamber C1 and a high chamber C2, with an input tap (26) of the complex composition that is to be filtered emptying into the low chamber C1, an output tap (28) of the retentate with elements for adjusting the flow rate emptying into this same low chamber C1, and an output tap (36, 36-1) of the high chamber C2, whereby this output tap (36, 36-1) of the permeate is subjected to negative pressure.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: December 9, 2014
    Assignee: Direction et Priorites
    Inventors: Francis Gadrat, Bertrand Chastenet
  • Publication number: 20140350450
    Abstract: Systems and methods are provided for performing a medical procedure with respect to a subject. A data storage location of the system is pre-programmed with a plurality of subject data entries, each having subject-specific information associated with it. A user interface receives an identity input from a subject, which corresponds to the identity of the subject. A controller is associated with the database and the user interface, and is programmed to compare the identity input to the subject data entries. If the identity input corresponds to the subject-specific information of a subject data entry, the controller commands a treatment device to perform a medical procedure with respect to the subject. Otherwise, if the identity input does not correspond to the subject-specific information of any of the subject data entries, the controller generates an error signal which prevents the performance of the medical procedure with respect to the subject.
    Type: Application
    Filed: August 8, 2014
    Publication date: November 27, 2014
    Applicant: Fenwal, Inc.
    Inventors: Brian C. Case, Lan T. Nguyen
  • Patent number: 8881600
    Abstract: In a process for testing filters (4) and (13) of treatment fluid of a hemodiafiltration apparatus (1), each filter has a wet semipermeable membrane (5, 14) which separates a gas-filled first chamber (6 and 15) from a liquid-filled second chamber (7 and 16). The first chambers are pressurised by a pump (19) supplying air, while the second chambers are placed in depression by a drainage pump (17) of used dialysis fluid. A first closed system is formed which includes the first chambers and a second closed system is formed which includes the second chambers. Two pressure gauges (P1 and P2) monitor the pressure in the two closed systems for a predetermined time. The monitoring provides indications relating to the filter integrity.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: November 11, 2014
    Assignee: Gambro Lundia AB
    Inventors: Anna Puppini, Renato Pedrazzi, Mauro Suffritti
  • Patent number: 8877062
    Abstract: The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: November 4, 2014
    Assignee: Interface Biologics, Inc.
    Inventors: Sanjoy Mullick, Weilun Chang, Hanje Chen, Mark Steedman, Roseita Esfand
  • Patent number: 8865172
    Abstract: A method for reducing the number of selected antibodies in a subject's blood, the method comprising removing blood from the subject, passing the blood along an enclosed pathway, wherein the pathway comprises one or more semi-permeable hollow fibers with one or more membranes having surfaces positioned substantially perpendicular to the length of the one or more hollow fiber and antigens specific for the antibodies immobilized on the one or more membranes, returning the treated blood to the internal circulation of the subject, wherein the returned treated blood has a reduced number of selected antibodies compared to before treatment.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: October 21, 2014
    Assignee: Advanced Extravascular Systems, Inc.
    Inventor: Duke K. Bristow
  • Patent number: 8852140
    Abstract: Systems and methods are provided for automatically adjusting the operational parameters of a blood separation procedure. A blood separation device has an inlet for passing fluid thereinto and an outlet for removing fluid therefrom. A pump system is provided for moving fluid into and out of the device. In use, blood is conveyed into the device, where platelets are separated from at least a portion of the blood. A controller determines the amount of platelets in the device. Based at least in part on the amount of platelets in the device, corrective action is taken to avoid platelet aggregation in the device. The corrective action may be conveying an elevated amount of anticoagulant into the blood and/or the device and may be initiated when the determined amount of platelets approaches, meets, or exceeds a threshold predicted likelihood of platelet aggregation.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: October 7, 2014
    Assignee: Fenwal, Inc.
    Inventors: John W. Barry, Jr., Brian C. Case, Lan T. Nguyen
  • Patent number: 8834719
    Abstract: A dialysis machine method includes in an embodiment applying a pneumatic closing pressure to a first valve chamber and arranging a compliance chamber to flex and absorb energy from the pneumatic closing pressure so as to tend to prevent the pneumatic closing pressure from opening an existing closure of a second valve chamber.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: September 16, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Robert W. Childers, Thomas D. Kelly, Rodolfo Roger
  • Patent number: 8834401
    Abstract: A process and apparatus are provided for managing and adjusting glucose levels in the blood of a patient during dialysis. The apparatus is a dialysis apparatus to treat patients with renal disease which includes a glucose scavenger to remove excess glucose from the blood before returning the blood to the patient and/or a device to increase blood glucose levels in the blood when the glucose level is below a threshold level. The glucose scavenger can include a glucose binding protein, boronic acid derivative, boronic ester derivative or mixture thereof bonded to the surface of a support such as a fiber bundle in a cartridge or the inner surface of tubing used in the apparatus.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: September 16, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: James R. Petisce, Andrew Metters
  • Patent number: 8808217
    Abstract: A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: August 19, 2014
    Assignee: Haemonetics Corporation
    Inventors: Toshiyasu Ohashi, Etienne Pagès, Dominique Uhlmann, Pascal Maillard, Michael Ragusa
  • Patent number: 8764695
    Abstract: The invention is directed to the removal of serum gal-3 from circulation by plasmapheresis using gal-3 binding agents in either a fixed bed, or in a form easily removed, such as by being complexed with magnetic particles. This method, on its own, brings a sharp reduction and relief from the inflammation and fibroses that can be induced by circulating gal-3. The process may be combined with the administration of gal-3 binding agents, such as modified citrus pectin, to further lower unbound gal-3 levels, to the point where gal-3 in the tissues may be addressed. This method may also be combined with removal of TNF receptors to provide an effective treatment for cancer.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: July 1, 2014
    Inventor: Isaac Eliaz
  • Publication number: 20140148750
    Abstract: A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.
    Type: Application
    Filed: January 29, 2014
    Publication date: May 29, 2014
    Applicant: Haemonetics Corporation
    Inventors: Etienne Pagès, Michael Ragusa
  • Patent number: 8708944
    Abstract: A system for harvesting a fibrin clot and depositing that fibrin clot into a wound site during a surgical procedure, the system comprising: (i) blood drawing apparatus for drawing blood; (ii) extraction apparatus for extracting fibrin from blood so as to form a fibrin clot; (iii) configuring apparatus for molding, cutting and shaping the fibrin clot into a desired configuration; and (iv) dispensing apparatus for reliably and controllably dispensing the fibrin clot at a selected location in the body.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: April 29, 2014
    Inventors: Javin C. Pierce, Peter Kurzweil
  • Patent number: 8702637
    Abstract: A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: April 22, 2014
    Assignee: Haemonetics Corporation
    Inventors: Etienne Pagès, Michael Ragusa
  • Patent number: 8684959
    Abstract: An extracorporeal blood treatment apparatus comprises a sensor (10) for emitting a signal indicating a change of hematic volume of an individual (7) subjected to a treatment and a weight loss system for actuating the individual's weight loss. A control unit (20) receives an effective weight value of the individual and a desired weight loss value and from these values determines a desired value of a change in hematic volume at end of treatment. The weight loss system is controlled on a basis of the hematic volume change signal and the desired value of the hematic volume change. The apparatus enables automatic control of a dialysis operation while preventing some complications arising from hypotension.
    Type: Grant
    Filed: July 3, 2009
    Date of Patent: April 1, 2014
    Assignee: Gambro Lundia AB
    Inventors: Francesco Paolini, Francesco Fontanazzi, Fabio Grandi
  • Patent number: 8647289
    Abstract: A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: February 11, 2014
    Assignee: Haemonetics Corporation
    Inventors: Etienne Pagès, Michael Ragusa
  • Patent number: 8632486
    Abstract: An access disconnect system includes a blood processing machine having a blood pump operable with blood tubing, first and second conductive contacts located in the blood tubing on an arterial tubing side of a blood filter. The first conductive contact is located upstream of the blood pump and the second conductive contact is located downstream of the blood pump. The first and second conductive contacts are positioned and arranged to form a conductive circuit including a vascular system of a patient and the blood processing machine. The system further includes a source of electric current connected to at least one of the first and second conductive contacts and a transmitter for sending a signal indicative of an amount of current flowing through the conductive circuit when the source of electric current is applied.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: January 21, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventor: Matthew R. Muller
  • Patent number: RE45315
    Abstract: A whole blood collection system includes an automated pump/control unit and an accompanying disposable blood set. When combined and connected to a source of anticoagulant, these elements allow automatic priming of the blood set with anticoagulant and automatic collection of anticoagulated blood product according to three different collection modes. The unit's pump and the blood set are specially designed to cooperate during the collection process to assure that the collected product has a precise blood to anticoagulant ratio. During the collection procedure, the pump/control unit automatically collects data relating to the procedure. Additional data specifically identifying components of the blood set, such as the blood collection bag, along with identification data on the donor's registration form may be scanned into the pump/controller unit by a scanner associated with the unit; this facilitates positive sample identification and tracking.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: December 30, 2014
    Assignee: Haemonetics Corporation
    Inventors: Ronald O. Gilcher, Jacques Chammas, Joseph M. Medberry, Gary R. Stacey