Leukocyte Patents (Class 604/6.03)
  • Patent number: 11071618
    Abstract: An implantable lymph node replacement construct (10) comprising a body (12) having a plurality of inlets (24,26) and a lesser number of outlets (30). The body (12) further having an internal structure defining a fluid communication path through the body (12) from the inlets (24,26) to the outlet or outlets (30). The internal structure of the body (12) comprises an inlet portion (38), a convergent portion (40) and an outlet portion (42) such that lymph received by the construct (10) at the inlets (24,26) is conveyed through the inlet portion (38) of the internal structure to the convergent portion (40) whereupon the lymph is combined before passing to the outlet or outlets (30).
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: July 27, 2021
    Inventor: James E. Moore, Jr.
  • Patent number: 10894065
    Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: January 19, 2021
    Assignee: Astellas Institute for Regenerative Medicine
    Inventors: Qiang Feng, Shi-Jiang Lu, Robert P. Lanza
  • Patent number: 10842927
    Abstract: A blood treatment filter comprising a filter element, an inlet-side flexible container and an outlet-side flexible container, an inlet port, and a tubular outlet port, further comprises: an outlet-side frame sheet disposed between the filter element and the outlet-side flexible container; a first seal portion provided by sealing at least the filter element and the outlet-side frame sheet in a belt-shaped manner; and an annular second seal portion provided to surround the first seal portion, wherein on an outlet side of the filter element, a valley portion is formed at the first seal portion, the outlet port includes a protruding portion that protrudes to an inside of the container, and the protruding portion is provided with an opening at least a part of which overlaps with the first seal portion and which can communicate with a gap region formed by the valley portion.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: November 24, 2020
    Assignee: ASAHI KASEI MEDICAL CO., LTD.
    Inventors: Tomohisa Yokomizo, Tomoko Uchiyama
  • Patent number: 10646515
    Abstract: The present invention relates to composition comprising an isolated CD8+ Treg cell population, wherein the Treg cells have signatures for i) identifying that the T-cells are CD8+ regulatory Tcells, ii) identifying that the Treg cells are tissue type tropic, i.e they can migrate to the diseased tissue, iii) optionally identifying that the Treg cells are tropic with respect to the diseased tissue, i.e. they are homing cells, iv) identifying that the Treg cells are emigrant cells, i.e. they originate from the target tissue, and v) optionally identifying that the Treg cells are capable of being retained in the target tissue and optionally one or more X-signatures and/or one or more Y-signatures.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: May 12, 2020
    Assignee: GENOVIE AB
    Inventors: Reagan Micheal Jarvis, Magnus Thörn
  • Patent number: 10598662
    Abstract: An in vitro method for diagnosing and treating sepsis in a patient is provided, the method including: contacting at least a portion of a biological sample from the patient consisting essentially of microparticles isolated via differential centrifugation with reagents for detection and/or quantification of neutrophil-derived microparticles; determining a level of neutrophil-derived microparticles based on the contacting step; diagnosing sepsis in the patient when the determined level of neutrophil-derived microparticles is elevated relative to a cutoff value of the neutrophil-derived microparticles; and treating the diagnosed patient for sepsis.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: March 24, 2020
    Assignee: University of Cincinnati
    Inventors: Charles C. Caldwell, Kevin R. Kasten, Priya S. Prakash, Bobby L. Johnson, III
  • Patent number: 10478537
    Abstract: An object of the present invention is to provide a novel filter material and a filter including the same. Specifically, the present invention aims to provide a filter material capable of filtering in a short period of time, without clogging of the filter, while maintaining high cell separation properties, and a filter including the same. More specifically, the present invention aims to provide a filter material in which fiber masses (flocs) are uniformly distributed, and a filter including the same. The present invention provides a novel filter material showing excellent cell separation properties and excellent flow-through properties regardless of design choices for filters known prior to the filing of the present application, and an efficient cell separation method using a novel filter on which the filter material is stacked.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: November 19, 2019
    Assignee: KANEKA CORPORATION
    Inventors: Ikuhiro Suzuki, Takayuki Miyamoto, Takao Shibata
  • Patent number: 10311970
    Abstract: A renal therapy machine with a blood pressure monitor is disclosed. In an example, a renal therapy machine includes a dialysis fluid pump a control processor for controlling a treatment performed by the dialysis fluid pump, and a user interface in operable communication with the control processor. The renal therapy machine also includes a blood pressure monitor in operable communication with the control processor. The blood pressure monitor includes a blood pressure cuff positioned and arranged to receive air pressurized from within the renal therapy machine for the purpose of taking a patient's blood pressure.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: June 4, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Neil Tiwari, Joshua James Miller, Marc Steven Minkus, Matthew R. Muller, Derek Wiebenson
  • Patent number: 10073097
    Abstract: Methods for assessing pneumonia in a patient, methods for managing treatment of a patient suspected of having pneumonia, and methods of managing treatment in a patient suffering from pneumonia. The method of assessing pneumonia includes contacting a biological sample with reagents for detection and/or quantification of neutrophil-derived microparticles, determining a level of neutrophil-derived microparticles, and assessing pneumonia if the level is elevated. The method of managing treatment of a patient suspected of having pneumonia includes assessing pneumonia by calculating a concentration of neutrophil-derived microparticles, treating the patient where pneumonia is indicated, and determining treatment response by measuring a post treatment concentration of neutrophil-derived microparticles.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: September 11, 2018
    Inventors: Charles C. Caldwell, Kevin R. Kasten, Priya S. Prakash, Bobby L Johnson, III
  • Patent number: 9763984
    Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.
    Type: Grant
    Filed: December 21, 2013
    Date of Patent: September 19, 2017
    Assignee: Astellas Institute for Regenerative Medicine
    Inventors: Qiang Feng, Shi-Jiang Lu, Robert P. Lanza
  • Patent number: 9468605
    Abstract: Pharmaceutical compositions and single unit dosage forms of apremilast, i.e., (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, or a pharmaceutically acceptable stereoisomer, prodrug, salt, solvate, hydrate, or clathrate, are provided herein. Also provided are methods of treating, managing, or preventing various disorders, such as diseases or disorders ameliorated by the inhibition of TNF-? production in mammals.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: October 18, 2016
    Assignee: Celgene Corporation
    Inventors: Darshan K. Parikh, Anil Menon, Anthony Tutino
  • Patent number: 9250242
    Abstract: This invention provides methods and compositions for capturing circulating tumor cells (CTCs) as well as various divergent CTC phenotypes using seprase-specific affinity reagents. Methods of analyzing CTCs and assessing their metastatic potential in vivo and in vitro are also disclosed.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: February 2, 2016
    Assignees: ROCHE MOLECULAR SYSTEMS, INC., THE UNIVERSITY OF NORTH CAROLINA
    Inventors: George Martin, Steven Soper, Makgorzata Witek, Jen Jen Yeh
  • Patent number: 8877177
    Abstract: An apheresis column loaded with a solid support comprises one or more chemokines, in particular biotinylated chemokines, immobilized directly or indirectly on the support, in particular on a support carrying streptavidin. Also disclosed are uses of the column and the support and a method of depleting cells, in particular leukocytes, from the peripheral blood of a person suffering from an inflammatory condition such as Inflammatory Bowel Disease (IBD).
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: November 4, 2014
    Assignee: ITH Immune Therapy Holdings AB
    Inventors: Ola Winqvist, Graham Cotton
  • Patent number: 8708945
    Abstract: An object of the present invention is to provide a method for suppressing surgical site infections (SSI) that have occurred at extremely high incidence rates at the time of surgical operations and particularly surgical operations on digestive system organs, and to provide a column to be used for the method. According to the present invention, a method is provided for suppressing surgical site infections, which comprises the steps of: (a) administering a chemotherapeutic drug for treating and/or preventing a surgical site infection; and (b) collecting blood from a surgical subject and removing leukocytes that comprise neutrophils from the blood during or within 24 hours after surgical operation, and then returning the blood from which the leukocytes have been removed to the surgical subject.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: April 29, 2014
    Assignee: Asahi Kasei Medical Co., Ltd.
    Inventors: Masato Kusunoki, Chikao Miki, Shigeyuki Yoshiyama
  • Publication number: 20130303960
    Abstract: The interface between nanotechnology and biological systems is used to synthetically replicate the body's vital, innate, immune functions with targeted precision. Through the creation and use of complexed nanodiamonds (or other particles) with capture agents in a flow-through return apparatus or in an analytic/diagnostic tool, the invention provides individualized treatment of blood-borne pathogens and disease spectrums and rapid, individualized diagnostics. The invention can be used, for example, to clear blood-borne pathogens during initial infections prior to tissue sequestration in real time, to decrease overwhelming numbers of bacterial/viral/cytokine load during life threatening infectious conditions, to super sensitize the immune system to a variety of conditions-cancer markers, vaccinates, etc.
    Type: Application
    Filed: January 5, 2012
    Publication date: November 14, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Angela Courtney, Abigail Spinner
  • Patent number: 8556844
    Abstract: A blood treatment device provides a photopheresis treatment using a microfluidic separation channel to separate blood components into layers The layering caused by laminar flow in the microfluidic separation channel allows light to be projected through plasma onto leukocytes without hindrance by erythrocytes.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: October 15, 2013
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Edward F. Leonard
  • Publication number: 20130261528
    Abstract: An apheresis tubing set comprises a cryocyte bag for collecting cells separated during apheresis. The cryocyte bag may comprise a mixing compartment in fluid communication with a cell storage compartment, wherein the mixing compartment comprises a cryoprotectant port and a cell sample port and wherein the storage and mixing compartments are in fluid communication via a mix conduit.
    Type: Application
    Filed: November 6, 2012
    Publication date: October 3, 2013
    Inventor: Glen James Wicks Delaronde-Wilton
  • Patent number: 8517967
    Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: August 27, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Keith Rosiello, Henrik Clausen
  • Patent number: 8449489
    Abstract: A method of treating inflammatory bowel disease (IBD) comprises providing an intestinal biopsy sample obtained from inflamed tissue of a patient; mechanically treating the sample to obtain a cell suspension; identifying cell surface markers of activated leukocytes selected from T lymphocytes, neutrophil granulocytes, and eosinophil granulocytes in the suspension; raising antibodies against one of more of the activated cells and immobilizing them on a support; providing a column loaded with the support; diverting a portion of the patient's peripheral blood to make it pass through the column before re-infusing it to the patient to make the activated leukocytes couple with antibodies on the support, thereby eliminating them from the blood stream. Also disclosed are corresponding columns and supports, and their use in the method.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: May 28, 2013
    Assignee: ITH Immune Therapy Holdings AB
    Inventors: Magnus Thorn, Ola Winqvist
  • Patent number: 8430832
    Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: April 30, 2013
    Assignees: The Regents of the University of Michigan, CytoPherx, Inc.
    Inventors: H. David Humes, Deborah Buffington
  • Patent number: 8425447
    Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: April 23, 2013
    Assignees: The Regents of the University of Michigan, CytoPherx, Inc.
    Inventors: H. David Humes, Deborah Buffington
  • Patent number: 8425446
    Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: April 23, 2013
    Assignees: The Regents of the University of Michigan, CytoPherx, Inc.
    Inventors: H. David Humes, Deborah Buffington
  • Patent number: 8426122
    Abstract: A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: April 23, 2013
    Assignee: Cellscape Corporation
    Inventors: Bhairavi Parikh, Michael D. Brody, James Stone, Jonathan D. Halderman
  • Patent number: 8425445
    Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: April 23, 2013
    Assignees: The Regents of the University of Michigan, CytoPherx, Inc.
    Inventors: H. David Humes, Deborah Buffington
  • Patent number: 8425448
    Abstract: This invention is directed to a method of collecting and separating whole blood into components. The method includes the steps of adding an anticoagulant having an acidic pH to a bag for collecting and/or separating whole blood, collecting whole blood in the bag, loading the bag containing anticoagulated whole blood on a rotor, spinning the bag on the rotor to separate the whole blood into at least one component; and squeezing the bag on the rotor to push the component from the separation bag into at least one satellite bag.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: April 23, 2013
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas Felt, Peter Pihlstedt, Bruce Gibbs
  • Patent number: 8409126
    Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: April 2, 2013
    Assignees: The Regents of the University of Michigan, CytoPherx, Inc.
    Inventors: H. David Humes, Deborah Buffington
  • Patent number: 8251941
    Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: August 28, 2012
    Assignees: The Regents of the University of Michigan, CytoPherx, Inc.
    Inventors: H. David Humes, Deborah Buffington
  • Patent number: 8231868
    Abstract: Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The maturation of the dendritic cells is truncated at a stage where the dendritic cells can inactivate T cell clones which would otherwise generate an undesired immune system response. The immature dendritic cells can be directly administered to the transplant recipient, or the dendritic cells can be co-incubated with the bone marrow or stem cell preparation, prior to transplantation, in order to suppress or eliminate anti-recipient donor T cells contaminating the bone marrow or stem cell preparation. The methods can be used to suppress graft versus host disease in recipients of transplanted bone marrow or stem cells, or to suppress rejection of transplanted organs or tissue.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: July 31, 2012
    Assignee: Yale University
    Inventors: Richard Leslie Edelson, Carole Berger, Michael Girardi
  • Patent number: 8197432
    Abstract: A method for batch implementation of settings in a renal replacement therapy device including: displaying on a user interface control settings which may be manually selected by an operator; selecting an independent control setting of the plurality of control settings; adjusting the independent control setting to an independent control setting level selected by an operator; temporarily storing the adjusted independent control setting level; automatically adjusting a dependent control setting level based upon the independent control level; displaying the adjusted independent control setting level and the adjusted dependent control setting, and implementing both the adjusted independent control setting level and the adjusted dependent control setting to control the device, by actuating a batch setting acceptance operation.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: June 12, 2012
    Assignee: Gambro UF Solutions, Inc.
    Inventors: John J. O'Mahony, Thomas Robert Lendway, Andrew J. Halpert
  • Patent number: 8092413
    Abstract: An improved tubing device, preferably for use in the medical industry is provided. The tubing device provides a seamless transport path by using the tubing itself as the transport means without any other internally wetted parts, or connections, to provide a substantial reduction in the number of fluid contact components, and eliminate the need for cutting tubes into segments to be later bonded via tubing connectors. This can reduce the risk of contamination of the transported materials and can also reduce the use of chemicals such as adhesives and bonding agents.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: January 10, 2012
    Inventors: Majid Zia, Anthony J. Angelo, Craig M. Wilson
  • Patent number: 8052667
    Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: November 8, 2011
    Assignee: Velico Medical, Inc.
    Inventors: Keith Rosiello, Henrik Clausen
  • Publication number: 20110196280
    Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
    Type: Application
    Filed: April 15, 2011
    Publication date: August 11, 2011
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INNOVATIVE BIOTHERAPIES, INC.
    Inventors: H. David Humes, Deborah Buffington
  • Patent number: 7988951
    Abstract: Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring induced anti-cancer immunity. In one embodiment, skin from the transplant donor is allografted to the transplant recipient to induce an immunological response to the transplanted skin. A quantity of blood is taken from the recipient and treated to render the T cells in the blood apoptotic and to induce differentiation of blood monocytes into dendritic cells. The treated blood is incubated and administered to the recipient to induce formation of suppressor T cell clones which reduce the number of T cells attacking the transplanted tissue or organ. This tolerogenic approach can be complemented by also feeding the immature dendritic cells apoptotic or necrotic cells from the organ donor.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: August 2, 2011
    Assignee: Yale University
    Inventor: Richard Leslie Edelson
  • Patent number: 7850969
    Abstract: The present invention provides a module for reducing the activity of leukocytes which comprises a carrier and a ligand that is linked to the carrier and is suitable for interacting with a leukocyte receptor. Furthermore, the present invention provides a process for reducing the activity of leukocytes using said module. The advantage of the present invention is that after binding the activated leukocytes in the leukocyte inactivation module (LIM), the damaging effect of the cells is inhibited within minutes.
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: December 14, 2010
    Assignee: Leukocare GmbH
    Inventor: Martin Scholz
  • Publication number: 20100266562
    Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
    Type: Application
    Filed: June 30, 2010
    Publication date: October 21, 2010
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INNOVATIVE BIOTHERAPIES, INC.
    Inventors: H. David Humes, Deborah Buffington
  • Publication number: 20100268146
    Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
    Type: Application
    Filed: June 30, 2010
    Publication date: October 21, 2010
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INNOVATIVE BIOTHERAPIES, INC.
    Inventors: H. David Humes, Deborah Buffington
  • Publication number: 20100266563
    Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
    Type: Application
    Filed: June 30, 2010
    Publication date: October 21, 2010
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INNOVATIVE BIOTHERAPIES, INC.
    Inventors: H. David Humes, Deborah Buffington
  • Publication number: 20100268147
    Abstract: The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
    Type: Application
    Filed: June 30, 2010
    Publication date: October 21, 2010
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INNOVATIVE BIOTHERAPIES, INC.
    Inventors: H. David Humes, Deborah Buffington
  • Patent number: 7789847
    Abstract: A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures involve filtering the separated red blood cells in a diluted state after and/or prior to flushing the filter with storage solution. Storage solution may thus be passed through the leukoreduction filter before, with and/or after the RBCs have been filtered therethrough. The red blood cell collection, filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: September 7, 2010
    Assignee: CaridianBCT, Inc.
    Inventors: Bruce W. Gibbs, Jon Herskovits
  • Publication number: 20100210989
    Abstract: Methods (300), devices, and systems of processing blood are described. The method (300) comprises the steps of: obtaining (312) blood from a patient coupled to a single blood processing device to form a closed loop between the patient and the blood processing device; collecting (314) bulk mononuclear blood cells from the blood by leukapheresis implemented using the blood processing device in the closed loop; and enriching (316) concurrently target cells separated from non-target cells in the bulk mononuclear blood cells using the blood processing device in the closed loop.
    Type: Application
    Filed: December 1, 2009
    Publication date: August 19, 2010
    Inventors: Janet Lesley Macpherson, David Perritt, Kevin Henrichsen, Geoffrey Phillip Symonds, Susan Pond, Philip Wong
  • Patent number: 7727523
    Abstract: Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The maturation of the dendritic cells is truncated at a stage where the dendritic cells can inactivate T cell clones which would otherwise generate an undesired immune system response. The immature dendritic cells can be directly administered to the transplant recipient, or the dendritic cells can be co-incubated with the bone marrow or stem cell preparation, prior to transplantation, in order to suppress or eliminate anti-recipient donor T cells contaminating the bone marrow or stem cell preparation. The methods can be used to suppress graft versus host disease in recipients of transplanted bone marrow or stem cells, or to suppress rejection of transplanted organs or tissue.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: June 1, 2010
    Assignee: Yale University
    Inventors: Richard Leslie Edelson, Carole Berger, Michael Girardi
  • Patent number: 7708710
    Abstract: Methods are disclosed for collecting and separating whole blood into one or more components. A disposable blood separation fluid circuit is provided which is adapted to cooperate with a reusable separation controller. The fluid circuit includes a fluid flow path for communication with a blood source and at least one container in fluid communication with the fluid flow path. The fluid flow path is connected to a blood source and quantities of whole blood are collected in the container and one other location within the fluid circuit. The source is then disconnected from the disposable fluid circuit. The quantities of whole blood are centrifugally processed, with processing of at least a portion of one of the quantities beginning after the source is disconnected from the fluid circuit.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: May 4, 2010
    Assignee: Fenwal, Inc.
    Inventors: Kyungyoon Min, Richard I. Brown
  • Publication number: 20100081985
    Abstract: This invention relates to a method of reducing residual white blood cells in an apheresed platelet product. The method includes the steps of adding to the platelet product a solution comprising sodium chloride and magnesium and inducing degradation of the residual white blood cells.
    Type: Application
    Filed: October 1, 2009
    Publication date: April 1, 2010
    Applicant: CARIDIANBCT, INC.
    Inventors: John PITTINGER, Anna RAZATOS
  • Patent number: 7686779
    Abstract: A preconnected disposable and method for red blood collection is provided wherein the preconnected disposable includes a red blood cell collection assembly comprising a leukoreduction filter and a red blood cell storage bag. Such a red blood cell collection assembly is preferably preconnected to a blood component separation vessel, cassette assembly and a blood removal/return assembly for removing blood from a donor, separating the blood into components for collection and providing for filtration of the separated red blood cell component.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: March 30, 2010
    Assignee: Caridian BCT, Inc
    Inventor: Bruce W. Gibbs
  • Patent number: 7682329
    Abstract: A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures involve filtering the separated red blood cells in a diluted state after and/or prior to flushing the filter with storage solution. Storage solution may thus be passed through the leukoreduction filter before, with and/or after the RBCs have been filtered therethrough. The red blood cell collection, filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component.
    Type: Grant
    Filed: April 6, 2006
    Date of Patent: March 23, 2010
    Assignee: CaridianBCT, Inc.
    Inventors: Bruce W. Gibbs, Jon Herskovits
  • Patent number: 7625351
    Abstract: Provided herein is an innovative hemoperfusion system and method including a thermal-fused broad-spectrum biocidal iodinated interactive polymer for the treatment of biological contaminants in body fluids. In one exemplary embodiment, the system and method utilizes a Triosyn® thermal fused broad-spectrum iodinated interactive polymer, included in a hemoperfusion column, for devitalizing high levels of cell-free microorganisms in whole blood and biological fluids in relation with the characterization of blood cells viability and function post-treatment.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: December 1, 2009
    Assignee: Triosyn Holding, Inc.
    Inventor: Pierre Messier
  • Patent number: 7625557
    Abstract: Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring induced anti-cancer immunity. In one embodiment, skin from the transplant donor is allografted to the transplant recipient to induce an immunological response to the transplanted skin. A quantity of blood is taken from the recipient and treated to render the T cells in the blood apoptotic and to induce differentiation of blood monocytes into dendritic cells. The treated blood is incubated and administered to the recipient to induce formation of suppressor T cell clones which reduce the number of T cells attacking the transplanted tissue or organ. This tolerogenic approach can be complemented by also feeding the immature dendritic cells apoptotic or necrotic cells from the organ donor.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: December 1, 2009
    Assignee: Yale University
    Inventor: Richard Leslie Edelson
  • Publication number: 20090275874
    Abstract: The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of ?20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.
    Type: Application
    Filed: March 31, 2006
    Publication date: November 5, 2009
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Masaaki Shimagaki, Yasufumi Yamamura, Katsuhisa Sato, Kazuo Teramoto, Takeshige Oozeki, Shigehisa Wada
  • Publication number: 20090209898
    Abstract: This invention describes a method for pumping or delivering fluids utilizing a flexible vessel subject to controlled pressures within another pressure vessel. The pressure vessel can be sourced with positive and/or negative (e.g., vacuum) pressure.
    Type: Application
    Filed: April 21, 2009
    Publication date: August 20, 2009
    Applicant: THERAKOS, INC.
    Inventor: Dennis A. Briggs
  • Publication number: 20090204051
    Abstract: The present invention relates to a method of body fluid treatment for relieving the condition of inhibited lymphocyte proliferation which comprises bringing a mammalian body fluid into contact with an adsorbent comprising a high-molecular compound having a water contact angle within the range of 40° to 98° in the presence of a divalent cation chelating agent in the manner of extracorporeal circulation, or comprises bringing a mammalian body fluid into contact with an active carbon-containing adsorbent in the manner of extracorporeal circulation; and relates to a system for extracorporeal circulation which comprises a body fluid transfer pump, an anticoagulant infusion pump, and a device comprising a container wherein an adsorbent comprising a high-molecular compound having a water contact angle within the range of 40° to 98° is contained, or comprises a body fluid transfer pump, and a device comprising a container wherein an active carbon-containing adsorbent is contained.
    Type: Application
    Filed: March 29, 2006
    Publication date: August 13, 2009
    Applicant: Kaneka Corporation
    Inventors: Akira Kobayashi, Shinya Yoshida, Hideo Niwa
  • Publication number: 20090192434
    Abstract: A method of treating inflammatory bowel disease (IBD) comprises providing an intestinal biopsy sample obtained from inflamed tissue of a patient; mechanically treating the sample to obtain a cell suspension; identifying cell surface markers of activated leukocytes selected from T lymphocytes, neutrophil granulocytes, and eosinophil granulocytes in the suspension; raising antibodies against one of more of the activated cells and immobilizing them on a support; providing a column loaded with the support; diverting a portion of the patient's peripheral blood to make it pass through the column before re-infusing it to the patient to make the activated leukocytes couple with antibodies on the support, thereby eliminating them from the blood stream. Also disclosed are corresponding columns and supports, and their use in the method.
    Type: Application
    Filed: May 14, 2007
    Publication date: July 30, 2009
    Applicant: IBD COLUMN THERAPIES INTERNATIONAL AB
    Inventors: Magnus Thorn, Ola Winqvist