Filter Means Patents (Class 604/6.09)
  • Patent number: 10342912
    Abstract: Dialysis is enhanced by using nanoclay sorbents to better absorb body wastes in a flow-through system. The nanoclay sorbents, using montmorillonite, bentonite, and other clays, absorb significantly more ammonium, phosphate, and creatinine, and the like, than conventional sorbents. The montmorillonite, the bentonite, and the other clays may be used in wearable systems, in which a dialysis fluid is circulated through a filter with the nanoclay sorbents. Waste products are absorbed by the montmorillonite, the bentonite, and the other clays and the dialysis fluid is recycled to a patient's peritoneum. Using an ion-exchange capability of the montmorillonite, the bentonite, and the other clays, waste ions in the dialysis fluid are replaced with desirable ions, such as calcium, magnesium, and bicarbonate. The nanoclay sorbents are also useful for refreshing a dialysis fluid used in hemodialysis and thus reducing a quantity of the dialysis fluid needed for the hemodialysis.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: July 9, 2019
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA
    Inventors: Rosa H. Yeh, Wei Xie, Hsinjin E. Yang, Michael T. K. Ling, Ying-Cheng Lo
  • Patent number: 10335534
    Abstract: Systems and methods are provided for determining an estimated risk of arrhythmia during or after dialysis based on changes in serum potassium concentration of a patient and an amount of fluid removed from the patient during dialysis. The systems and methods allow for a determination of a risk that arrhythmia will occur due to the changes in potassium and fluid volume of a patient during dialysis, and for optimizing a dialysis prescription in order to minimize the risk of arrhythmia.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: July 2, 2019
    Assignee: Medtronic, Inc.
    Inventors: Amy Roettger, VenKatesh R. Manda, John Burnes, Rebecca Poindexter, Martin T. Gerber
  • Patent number: 10258729
    Abstract: A method for pumping and oxygenating blood includes receiving a flow of gas including oxygen into a gas inlet manifold via a gas inlet. The flow of gas is passed through the hollow fibers from the gas inlet manifold to a gas outlet manifold. The flow of gas is output from the gas outlet manifold via a gas outlet. An impeller is rotated to generate a flow of blood that flows over the hollow fibers. Oxygen from the flow of gas is transferred to the flow of blood through the hollow fibers. Carbon dioxide is transferred from the flow of blood to the flow of gas through the hollow fibers.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: April 16, 2019
    Assignees: Thoratec LLC, University of Maryland, Baltimore
    Inventors: Barry N. Gellman, Andrew Koert, Zhongjun Wu, Juntao Zhang, Bartley P. Griffith
  • Patent number: 10195336
    Abstract: There are provided a blood purification apparatus and a priming method thereof which can reliably perform air bubble purging of a blood purification device while workability is maintained during priming. During the priming, an air purging step is performed by causing a blood pump to perform reverse rotation, and electromagnetic valves and are brought into an opened state so as to open the overflow line (L) and a priming solution supply line and so as to discharge a priming solution from an overflow line while supplying a dialysate functioning as the priming solution from the priming solution supply line.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: February 5, 2019
    Assignee: NIKKISO COMPANY LIMITED
    Inventors: Kentaro Kogoshi, Satoshi Takeuchi
  • Patent number: 10130744
    Abstract: An apparatus for extracorporeal blood treatment comprises a sensor (10) for emitting a signal indicating a variation in blood volume (?Bv?) of an individual (7) subjected to extracorporeal blood treatment and a sensor (14) for emitting a signal indicating a weight loss of the individual. A control unit (20) receives the signals, compares the ratio between the relative variation of blood volume (?Bv/BV) and the relative variation of weight loss (AWL/TW) of the individual with a desired value, and controls the weight loss of the individual on the basis of the comparison. The apparatus enables automatically controlling a dialysis, preventing some complications due to hypotension.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: November 20, 2018
    Assignee: Gambro Lundia AB
    Inventors: Francesco Fontanazzi, Francesco Paolini, Fabio Grandi
  • Patent number: 10111999
    Abstract: Devices and methods for enhancing the operations of fluid systems are provided. For example, this document provides variable-elevation drop tubes that are well suited for use with medical fluid reservoirs. While the variable-elevation drop tubes provided herein are described in the context of a medical fluid system, such as an extracorporeal blood flow circuit, it should be understood that the devices and methods provided herein are not limited to such contexts.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: October 30, 2018
    Assignee: Terumo Cardiovascular Systems Corporation
    Inventors: Gregory Peter Muennich, Michael Washko, Timothy John Canatella
  • Patent number: 9931456
    Abstract: An extracorporeal treatment assembly including a pump and a controller wherein an extracorporeal circuit is mounted to the assembly, the controller causes the assembly to: control the pump to pump liquid through the passage and the flow coupling; collect actual fluid pressure data; store circuit type data uniquely corresponding to a certain type of extracorporeal circuit; determine a dimension of the certain type of extracorporeal circuit; determine an expected fluid pressure for the certain type of extracorporeal circuit; based on a comparison of the actual fluid pressure data and the expected fluid pressure, determine whether the certain type of extracorporeal circuit corresponds to the actual extracorporeal circuit.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: April 3, 2018
    Assignee: Gambro Lundia AB
    Inventors: Paolo Rovatti, Fabio Roncadi, Bruno Genovese, Pier Giorgio Verdi
  • Patent number: 9907894
    Abstract: A hemodialysis apparatus 1 is provided with a dialyzer 2 for performing hemodialysis, a blood circuit 3 connected to the dialyzer, a dialysis solution circuit 4 connected to the dialyzer, a replacement fluid port 31 provided in the dialysis solution circuit and capable of being opened and closed by a lid member, and a replacement fluid passage 6 having its one end connected to the blood circuit and the other end connected to the replacement fluid port.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: March 6, 2018
    Assignee: SHIBUYA KOGYO CO., LTD.
    Inventor: Takashi Mishima
  • Patent number: 9874559
    Abstract: Embodiments of the invention relate generally to devices and methods for pumping and controlling the flow of a fluid. More particularly, embodiments of the invention relate to capacitive pumping and flow control devices and methods. In one embodiment, the invention provides a pump system having an inlet valve, an outlet valve, and a chamber between and in communication with each of the inlet valve and the outlet valve, the chamber having at least one elastic surface, wherein the chamber will dilate in response to a fluid exerting a pressure on the elastic surface, contain a quantity of the fluid when so dilated, and discharge the quantity of the fluid through the opened outlet valve.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: January 23, 2018
    Assignee: INANOVATE, INC.
    Inventors: James Curtis Nelson, David Ure
  • Patent number: 9867939
    Abstract: Described are devices, systems, and methods for processing adipose tissue for reintroduction into a body. In some embodiments, adipose tissue is mixed with an additive prior to reintroduction.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: January 16, 2018
    Assignee: Allergan, Inc.
    Inventors: Justin Schwab, Mike Augarten, Darin Messina, Jason Metzner, Ethan Franklin
  • Patent number: 9795730
    Abstract: A blood treatment method is described that is adapted to at least partially eliminate the carbon dioxide content of the type comprising a step of drawing a blood flow. Advantageously according to the invention, the method further comprises the steps of: acidifying the blood flow with transformation of the related blood bicarbonate content into gaseous carbon dioxide; and eliminating the gaseous carbon dioxide content by means of a pressure gradient.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: October 24, 2017
    Assignee: Universitá Degli Studi di Milano-Bicocco
    Inventors: Antonio Maria Pesenti, Nicolo Antonino Patroniti
  • Patent number: 9592332
    Abstract: The present invention relates to a method of removing blood from an extracorporeal blood circuit following termination of a blood treatment session, wherein blood is concurrently removed both from an arterial conduit portion and from a venous conduit portion of the extracorporeal blood circuit. It further relates to a method for recognizing and/or eliminating air inclusions in or from an extracorporeal blood circuit and a treatment apparatus as well as a tube system.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: March 14, 2017
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Goetz Guenther, Joachim Manke
  • Patent number: 9579440
    Abstract: Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: February 28, 2017
    Assignee: OUTSET MEDICAL, INC.
    Inventors: Michael Edward Hogard, Gopi Lingam, Dean Hu, Balaji M. Maniam, James Ritson, Andy H. Uchida, John David Stienmier, Paul David McGregor
  • Patent number: 9364597
    Abstract: The present invention relates to a method as well as a blood treatment unit for the implementation of this method for the best possible attainment of a predetermined substitution target during the ultrafiltration of blood. According to the invention, a method and a blood treatment unit for the implementation of the method is provided, wherein it is determined by detection of pressure measurement values in the blood treatment unit whether the calculated substitution target is achieved at the end of the dialysis session or not and in case of the result that the calculated substitution target cannot be achieved with the current dialysis parameters, an adjustment of the flow rate of blood, dialysate and/or substituate is performed in order to achieve the substitution target for a given treatment time in an optimal way or modify the treatment time for the given substitution target as little as possible.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: June 14, 2016
    Assignee: B. BRAUN AVITUM AG
    Inventors: Henrik Wolff, Stefan Moll
  • Patent number: 9310232
    Abstract: The invention relates to a method for calibrating sensors, in particular RFID sensors, within an enclosure such as, e.g., a sterilization chamber. It furthermore relates to a sensor calibrated by the method of the invention, a disposable device including such a sensor, as well as a treatment device.
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: April 12, 2016
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Alexander Heide, Klaus Metzner
  • Patent number: 9283311
    Abstract: An oxygenator includes: a housing; a hollow fiber membrane bundle stored in the housing and having multiple integrated hollow fiber membranes with a gas exchange function; a gas inlet portion and a gas outlet portion provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes, respectively; a blood inlet portion and a blood outlet portion provided on the upstream and downstream of blood passages outside the hollow fiber membranes, respectively; a first filter member provided on the hollow fiber membrane bundle in contact with a blood outlet portion side surface so as to cover substantially the entire surface and has a function to catch bubbles in blood; and a second filter member that is separated from the first filter member, positioned between the first filter member and the blood outlet portion, and has a function to catch bubbles in blood.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: March 15, 2016
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Kazuhiko Takeuchi
  • Patent number: 9278168
    Abstract: An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: March 8, 2016
    Assignee: THORATEC LLC
    Inventors: Barry N. Gellman, Andrew Koert, Zhongjun Wu, Juntao Zhang, Bartley P. Griffith
  • Patent number: 9220834
    Abstract: A pressure sensor for a medical injection system includes a cuff, a transducer embedded in the cuff, and a force transmitting member coupled to the transducer and exposed at an inner surface of the cuff, such that an outer surface of a tubing line of a fluid circuit of the system, when fitted within the cuff, contacts the force transmitting member. A limited length of the tubing line may have a greater compliance than a remainder of the line, in which case, the pressure sensor cuff fits around and encloses the limited length to provide support against plastic deformation, when pressures within the line are significantly greater than atmospheric. The pressure sensor may detect whether or not the cuff is properly fitted around the tubing line, and/or determine a characteristic of the tubing line.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: December 29, 2015
    Assignee: ACIST Medical Systems, Inc.
    Inventor: Clinton Scott Vilks
  • Patent number: 9186451
    Abstract: The present invention relates to a method for priming a line for adding a medical solution, the line branching off a return line of an extracorporeal blood circuit, in particular a calcium line, a control device for controlling or regulating the method according to the present invention and a blood or plasma treatment apparatus with at least the control device according to the present invention. It further relates to a digital storage medium, a computer program product as well as a computer program.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: November 17, 2015
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Josef Beden, Olaf Kessel-Deynet, Juergen Klewinghaus, Thomas Pusinelli, Pascal Werner
  • Patent number: 9138527
    Abstract: A retrograde flow system is configured for treating an artery. The system includes an arterial access device adapted to be introduced into an artery and receive blood flow from the artery. A shunt fluidly is connected to the arterial access device, wherein the shunt provides a pathway for blood to flow from the arterial access device to a return site. A flow control assembly is coupled to the shunt and is adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state. A shut-off valve assembly automatically blocks fluid flow through the shunt in response to injection of the fluid into the arterial access device.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: September 22, 2015
    Assignee: Silk Road Medical, Inc.
    Inventors: Richard J. Renati, Michi E. Garrison, Alan K. Schaer, Gregory M. Hyde
  • Patent number: 9050421
    Abstract: The invention relates to a calculation and control system for the determination of the state of a vascular access of a patient intended to follow successive sessions of extracorporeal blood treatment by extraction and return of the blood via the vascular access, the system comprising: means for determining the value of at least one hemodynamic extracorporeal parameter of the patient for at least two sessions; means for determining the value of the purification effectiveness of the treatment for at least two sessions; programmed means for determining a risk score relating to the state of the vascular access of the patient as a function of at least two values of the hemodynamic extracorporeal parameter and of at least two determined values of the purification effectiveness.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: June 9, 2015
    Assignee: Gambro Lundia AB
    Inventor: Bernard Bene
  • Patent number: 9039648
    Abstract: A dialysis system includes a dialysis fluid cassette-based membrane blood pump; a dialyzer in fluid communication with the blood pump: first and second dialysis fluid cassette-based balance chambers each having (i) a fresh dialysis fluid compartment in fluid communication with the dialyzer and (ii) a spent dialysis fluid compartment; a dialysis fluid cassette-based fresh dialysis fluid membrane pump in fluid communication with the fresh dialysis fluid compartments of the first and second balance chambers; a dialysis fluid cassette-based spent dialysis fluid membrane pump in fluid communication with the dialyzer and the spent dialysis fluid compartments of the first and second balance chambers; and arterial and venous lines in fluid communication with the dialyzer for patient connection, the arterial and venous lines each including a contact used for electrically detecting a patient access disconnection.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: May 26, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed Mutasem El Sayyid, Shahid Din
  • Patent number: 9039647
    Abstract: A system or method automates and optimizes citrate anticoagulant supplementation in a blood filtration circuit during CRRT. A processor-based control system interfaces with a blood filtration circuit to detect patient blood flow into the circuit, detect fluid loss through a hemofilter, and sense vital electrolyte concentrations in the blood flow, and in response, control the addition of citrate, substitution fluid, and electrolyte supplements to ensure stability of plasma concentrations in post-dilution flow returned to the patient. The controller executes the method embodied as process control algorithms for calculating an optimal citrate flow rate as a function of selected, detected, and calculated system parameters. Citrate may be added to the circuit separately, or as part of a substitution solution or a dialysate.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: May 26, 2015
    Assignee: NIKKISO CO., LTD.
    Inventor: Jean-Michel Lannoy
  • Publication number: 20150141897
    Abstract: Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include seven-stage de-airing of blood to provide automated cardiopulmonary replacement to sustain patient life during a medical procedure comprising repairing or replacing the heart valve in a patient.
    Type: Application
    Filed: September 23, 2014
    Publication date: May 21, 2015
    Inventors: Gerhard Muller-Spanka, Hans-Reinhard Zerkowski
  • Patent number: 9033908
    Abstract: The present invention relates to a device for the removal of toxic substances from dialysate fluid, blood or blood plasma, said device comprising i) a sorption-filter (E) for removing toxins, toxic solutes, toxic small and middle-sized molecules and protein bound toxins from the dialysate fluid, blood or bloodplasma, said sorption filter comprising a nanostructured material, a porous polymer matrix or a combination of the two, ii) an inlet (4) for entry of dialysate fluid, blood or blood plasma into said device, iii) an outlet (5) for the removal of purified dialysate fluid, blood or blood plasma from said device, and iv) a conduit connecting said inlet with said outlet and holding said sorption filter such that said dialysate fluid, blood or blood plasma is forced through said sorption filter.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: May 19, 2015
    Assignee: Nederlandse Organisatie voor toegepast—natuurwetenschappelijk onderzoek TNO
    Inventors: Stephanus Franciscus Schilthuizen, Lawrence Fabian Batenburg, Frank Simonis, Franky Flory Vercauteren
  • Patent number: 9024746
    Abstract: An automatic locking system for a medical treatment device helps to ensure that an assistant is present during treatment of a patient. Among the features disclosed biometric authentication to verify that a trained assistant is present, a presence detector to ensure the assistant is continuously present during treatment, and warning and recovery processes that allow intermittent lapses in the continuous presence of the assistant.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 5, 2015
    Assignee: Nxstage Medical, Inc.
    Inventors: Jeffrey H. Burbank, Dennis M. Treu, James M. Brugger
  • Patent number: 9011769
    Abstract: A blood reservoir may be used in combination with other elements such as a heart lung machine (HLM), oxygenator, heat exchanger, arterial filter and the like to form an extracorporeal blood circuit that may be employed in a procedure such as a bypass procedure. The blood reservoir may be configured to receive, filter and store blood from a number of sources including vent blood (from within the heart), venous blood (from a major vein), purge blood (from a sampling line) and cardiotomy or suction blood (from the surgical field).
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: April 21, 2015
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Claudio Silvestri, Gabriele Tommasi
  • Patent number: 9005440
    Abstract: Systems and methods for hemodialysis or peritoneal dialysis having integrated electrodialysis and electrodeionization capabilities are provided. In an embodiment, the dialysis system includes a carbon source, a urease source, an ED/EDI unit. The carbon source, urease source, and/or the ED/EDI unit can be in the form of removable cartridges.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: April 14, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Rongsheng Lin, Yuanpang Samuel Ding, James M. White, Ye Chen, Ying-Cheng Lo, Joshua Miller, Justin Rohde
  • Patent number: 8998837
    Abstract: An apparatus (1) for extracorporeal blood treatment comprising a blood treatment device (2) having a semipermeable membrane (5) which separates a blood chamber (3) from a fluid chamber (4). A used fluid line (7) connects the fluid chamber to a used fluid discharge. A first pump (8) controls the ultrafiltration through the semipermeable membrane. A second pump (9) arranged in the used fluid line downstream of the first pump keeps pressure between the first and the second pump at a constant predetermined value. The invention provides a protection system against any possible pressure change in the used fluid discharge in a hemodialysis or hemo(dia)filtration apparatus.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: April 7, 2015
    Assignee: Gambro Lundia AB
    Inventors: Massimo Fava, Mauro Suffritti, Anna Puppini
  • Patent number: 8992463
    Abstract: A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: March 31, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Michael E. Hogard, Donald D. Busby, Robert W. Childers, Yuanpang Samuel Ding, Katherine M. Holian, Mark E. Jablonski, Thomas D. Kelly, Ying-Cheng Lo, Shincy J. Maliekkal, Rodolfo G. Roger, Donald A. Smith, Atif M. Yardimci
  • Patent number: 8986238
    Abstract: Systems and methods for salvaging blood cells from an absorbent material are disclosed. In one exemplary aspect, such as system includes a rotatable basin having perforations to allow rinse solution from a stationary basin to reversibly flow therethrough to wash the blood cells from the absorbent material, thereby forming an effluent solution. The system further includes a hemoconcentrator in fluid communication with the stationary basin having first and second fluid outputs for discharging a diluent solution and a blood cell discharge solution from the effluent solution respectively. The blood cells can be salvaged from the blood cell discharge solution. The second fluid output is in fluid communication with the stationary basin for recycling the diluent solution as the rinse solution.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: March 24, 2015
    Assignee: Cyclone Medtech, Inc.
    Inventor: Len Robinson
  • Patent number: 8979788
    Abstract: A cardiopulmonary bypass system utilizing membrane-based reciprocating positive displacement blood pumps (“pod pumps”). In one aspect, the pod pumps are constructed to provide reduced shear forces on the blood being pumped. In another aspect blood flow through the pod pumps can be controlled by a controller using information from pressure sensors in the control chamber of the pod pumps. In another aspect, the pod pumps are included on a disposable unit that can be received and held by a receptacle means on a base unit, the base unit also providing pressurized control fluid to the pod pumps on the disposable unit through the receptacle means.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: March 17, 2015
    Assignee: DEKA Products Limited Partnership
    Inventors: Jason A. Demers, Larry B. Gray, James D. Dale, N. Christopher Perry, David E. Altobelli
  • Patent number: 8974405
    Abstract: A dialysis fluid cassette that includes a rigid body and a flexible backing covering a recessed portion of the rigid body to at least partially form a gas release chamber.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: March 10, 2015
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Thomas Irvin Folden, Martin Joseph Crnkovich, Christian Schlaeper, Lynn Jensen, Mohsen Reihanifam
  • Publication number: 20150056601
    Abstract: Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include multi-stage de-airing of blood to provide automated cardiopulmonary replacement to preserve the viability or one or more organs in a clinically dead organ donor or harvested donor organ for subsequent transplantation to an organ receiver patient.
    Type: Application
    Filed: July 30, 2014
    Publication date: February 26, 2015
    Inventors: Gerhard Muller-Spanka, Hans-Reinhard Zerkowski
  • Patent number: 8961445
    Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: February 24, 2015
    Assignee: Biomet Biologics, LLC
    Inventors: Douglas M. Arm, Michael Ponticiello, Surinder Mathur, Andrew G. Hood
  • Patent number: 8956317
    Abstract: In a single needle extracorporeal blood treatment apparatus, an ultrafiltration pump (10) performs a pure ultrafiltration of ultrafiltrate from an hemofilter (4). The blood may be continuously circulated through the hemofilter using a first pump (5), which alternates an higher flow rate during the arterial phase and a lower flow rate during the venous phase, and a second pump (6) which is maintained at a flow rate intermediate between said higher and lower flow rate. The apparatus may be used for treatment of Congestive Heart Failure.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: February 17, 2015
    Assignee: Gambro Lundia AB
    Inventor: Hiram Rada
  • Patent number: 8951220
    Abstract: The present invention relates to an apparatus for making extracorporeal blood circulation available, in particular a heart-lung machine, comprising a venous connection and an arterial connection, between which a blood reservoir, a blood pump and a bubble detector for the detection of air bubbles are provided, with, downstream of the bubble detector, an arterial line leading to the arterial connection via an arterial clamp and a bypass leading via a bypass clamp back into the blood reservoir which is connected to a pump extracting air from the blood reservoir. In addition, the present invention relates to a method of operating such an apparatus.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: February 10, 2015
    Assignee: ZOLL LifeBridge GmbH
    Inventors: Gerhard Brieske, Michael Brieske
  • Patent number: 8951484
    Abstract: Candidate cells, such as circulating tumor cells (CTCs), present with blood are captured using a multiple stage device, having successive stages configured to deviate candidate cells out of the blood while slowing down the flow rates of the deviated resultant for easier capture of CTCs through progressive stages. The devices can include separation channel and deviation channels formed of micro-post patterns dimensioned to deviate different desired candidate cells for analysis.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: February 10, 2015
    Assignee: The Regents of The University of Michigan
    Inventors: Tommaso F. Bersano-Begey, Daniel F. Hayes
  • Patent number: 8951219
    Abstract: A method includes initiating a blood fluid removal session of a patient; monitoring an indicator of tissue fluid volume of the patient, or a portion thereof, during the blood fluid removal session; monitoring an indicator of blood fluid volume of the patient during the blood fluid removal session; determining whether a ratio of the indicator of tissue fluid volume to indicator of blood fluid volume is outside of a predetermined range; and altering the rate of fluid removal during the blood fluid removal session if the ratio is determined to be outside of the predetermined range. A blood fluid removal system may be configured to carry out the method.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: February 10, 2015
    Assignee: Medtronic, Inc.
    Inventors: Martin Gerber, John Burnes, Suping Lyu, Manda R. VenKalesh, Bryant Pudil
  • Patent number: 8945037
    Abstract: A blood purification apparatus has a dialyzer (1), an arterial blood circuit (2) with a blood pump 4, a venous blood circuit 3, a dialysate introduction line L1, a dialysate discharge line L2, a substitution line L3, and a substitution pump 9 that supplies the dialysate flowing in the substitution line L3 to the arterial blood circuit 2. A control device (11) estimates or measures the concentration of blood in a dilution channel section A. The control device (11) controls the volume of dialysate supplied by the substitution pump 9 on the basis of the estimated or measured blood concentration.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: February 3, 2015
    Assignee: Nikkiso Company Limited
    Inventors: Shinya Hasegawa, Masahiro Toyoda
  • Patent number: 8945036
    Abstract: The present invention includes a comprehensive replacement fluid system and method for the delivery of regional citrate anticoagulation (RCA) to extracorporeal blood circuits, wherein the system may include an online clearance monitor (OCM) and a circuit effluent online sensor system (OSS) for the continuous determination of patient plasma content of ultrafilterable solutes.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: February 3, 2015
    Assignee: Henry Ford Health System
    Inventors: Balazs Szamosfalvi, Stanley Frinak, Jerry Yee
  • Patent number: 8939926
    Abstract: A system and method for removing gas bubbles from blood during circulatory assist procedures. An active filter apparatus forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: January 27, 2015
    Assignee: Indian Wells Medical, Inc.
    Inventors: David W. Wieting, Jay A. Lenker
  • Patent number: 8932469
    Abstract: A dialysis machine includes a blood circuit, a dialysate circuit, and a dialyzer placed in communication with the blood circuit and the dialysate circuit. The dialysis machine includes a priming sequence in which dialysate is used to prime a first portion of the dialysate circuit and a physiologically compatible solution, other than dialysate, is used to prime a second portion of the dialysate circuit, the dialyzer and the blood circuit.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: January 13, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Robert W. Childers, Thomas D. Kelly, Rodolfo Roger
  • Patent number: 8926543
    Abstract: The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: January 6, 2015
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Kazuhide Ohta, Hiroshi Miyamoto, Junji Takaba, Ako Nosé
  • Patent number: 8926551
    Abstract: Patients suffering from acute renal failure must be diagnosed and treated quickly so that a physician can confidently prescribe either peritoneal dialysis or hemodialysis. In one way of quickly treating the patients, software is used to calculate a suitable peritoneal dialysis prescription without regard to how short or how long a dialysis cycle is used, and without regard to a total dialysate fluid volume for a therapy. For patients with suitable peritoneal membrane transport properties, the software program suggests that, at least over a short period of time, unexpectedly high ultrafiltrate volumes and high clearances may be achieved.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: January 6, 2015
    Assignees: Baxter Healthcare Inc., Baxter Healthcare S.A.
    Inventors: Ying-Cheng Lo, Alp Akonur, Yuanpang S. Ding
  • Patent number: 8924458
    Abstract: This patent application relates generally to processing devices in the medical device area.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: December 30, 2014
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Roland Levin, Martin Joseph Crnkovich, Fei Wang, Michael Emmanuel Kotsos, Gregg Eric Fuhriman
  • Patent number: 8920356
    Abstract: A coupler includes a conductive polymer material that is so constructed and arranged to join tubing, wherein the conductive polymer material includes a conductive polymer component selected from the group consisting of polyaniline, polypyrrole, polythiophenes, polyethylenedioxythiophene, poly(p-phenylene vinylene) and mixtures thereof.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: December 30, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Sherwin Shang, Ramesh Wariar, Angel Lasso, George Lamberson, Dan F. Marcquenski, Jr., Jan Jensen, David Kuhn, Raf Castellanos
  • Patent number: 8915876
    Abstract: The present invention relates to a method for removing blood from an extracorporeal blood circuit and/or a functional device, each connectable or connected with a blood treatment apparatus for the purpose of blood treatment of a patient. The blood treatment apparatus of the method comprises or is connected with at least one extracorporeal blood circuit with a line having interior portions, the extracorporeal blood circuit comprising at least one arterial line section and at least one venous line section, wherein a first section of the arterial line section is configured to be connected with a second section of the venous line section, and further comprises at least one blood pump for conveying blood within the line interior portions. The method includes the step of operating the blood pump in a second conveying direction which is opposite to a first customary conveying direction. It further relates to corresponding apparatuses.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: December 23, 2014
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Soeren Gronau, Juergen Haecker, Ralf Mueller, Manfred Weis, Stefan Kreber, Martin Thys
  • Patent number: 8911666
    Abstract: A filter member used in an oxygenator is constructed to provide improved contact with a hollow fiber membrane bundle and to capture bubbles contained in blood. The filter member possesses elasticity at least in the circumferential direction to allow the inner circumference of the filter member to be increased from a natural non-expanded state prior to placement on the hollow fiber membrane bundle to an expanded state in which the inner circumference of the filter member is increased when placed on the hollow fiber membrane bundle. The filter member is constructed to satisfy the condition 0.5?L2/L1<1, wherein L1 represents the outer circumference of the hollow fiber membrane bundle and L2 represents the inner circumference of the filter member in the natural non-expanded state.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: December 16, 2014
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Kazuhiro Mizoguchi, Eiji Kato
  • Patent number: 8905960
    Abstract: A device for the filtration of a complex fluid composition such as blood, includes a base (12) with a bottom (18), a top (14) with a bottom (30), and a membrane (16) that is arranged between the base and the top so as to define a low chamber C1 and a high chamber C2, with an input tap (26) of the complex composition that is to be filtered emptying into the low chamber C1, an output tap (28) of the retentate with elements for adjusting the flow rate emptying into this same low chamber C1, and an output tap (36, 36-1) of the high chamber C2, whereby this output tap (36, 36-1) of the permeate is subjected to negative pressure.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: December 9, 2014
    Assignee: Direction et Priorites
    Inventors: Francis Gadrat, Bertrand Chastenet