Heating Or Cooling Means Patents (Class 604/6.13)
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Patent number: 8142718Abstract: A disposable that is suitable for application in a device for heating a physiological fluid, in particular blood, comprising a conduit for conducting fluid, which conduit comprises conduit sections that are arranged next to each other and bends that connect the conduit section, wherein at least one of the bends comprises a first turbulence-inducing obstruction.Type: GrantFiled: April 30, 2004Date of Patent: March 27, 2012Assignee: The Surgical Company International B.V.Inventors: Maurice Petrus Wilhelmus Tak, Jeroen Gerbert Hasperhoven
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Patent number: 8133195Abstract: In a device for handling blood in extracorporeal blood circulation that has at least one oxygenator, one heat exchanger, and one blood filter, the inlets and outlets in the oxygenator/heat exchanger unit are embodied such that a blood flow cross section of A?80 mm2, preferably A?120 mm2, is assured. The device can also be operated in an isolated form as a single structural part, which takes on the functions of an oxygenator and a heat exchanger with a blood filter. If a pump is provided in the device, then the pump drive can be removed as needed.Type: GrantFiled: July 3, 2006Date of Patent: March 13, 2012Assignee: Maquet Cardiopulmonary AGInventors: Rainer Blicke, Ulrich Haag, Enno-Utz Kueper
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Publication number: 20120046594Abstract: A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.Type: ApplicationFiled: August 20, 2010Publication date: February 23, 2012Inventors: Stefano Reggiani, Gianfranco Beniamino Fiore, Alberto Redaelli, Christian Baiotto
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Patent number: 8109894Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.Type: GrantFiled: February 4, 2011Date of Patent: February 7, 2012Assignees: Zoll Circulation, Inc., The Regents of the University of CaliforniaInventors: Wayne A. Noda, Mike L. Jones, Scott M. Evans, Blair D. Walker, William J. Worthen, Yves Pierre Gobin
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Patent number: 8109897Abstract: Methods for selective cooling or heating of a target site in the human body include a catheter having a supply elongated element and a delivery elongated element, with inlet and exit ports. Blood is withdrawn from the supply elongated element and cooled or heated in a control unit. The treated blood is sent to the targeted area via delivery elongated element. The supply elongated element can act as an insulator for the treated blood in the delivery elongated element.Type: GrantFiled: March 25, 2010Date of Patent: February 7, 2012Assignee: ThermopeutiX, Inc.Inventors: Ronald J. Solar, Glen Lieber
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Patent number: 8105262Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.Type: GrantFiled: February 3, 2011Date of Patent: January 31, 2012Assignees: Zoll Circulation, Inc., The Regents of the University of CaliforniaInventors: Wayne A. Noda, Mike L. Jones, Scott M. Evans, Blair D. Walker, William J. Worthen, Yves Pierre Gobin
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Patent number: 8105264Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.Type: GrantFiled: February 4, 2011Date of Patent: January 31, 2012Assignees: Zoll Circulation, Inc., The Regents of the University of CalifoniaInventors: Wayne A. Noda, Mike L. Jones, Scott M. Evans, Blair D. Walker, William J. Worchen, Yves Pierre Gobin
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Patent number: 8105263Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.Type: GrantFiled: February 3, 2011Date of Patent: January 31, 2012Assignees: Zoll Circulation, Inc., The Regents of the University of CaliforniaInventors: Wayne A. Noda, Mike L. Jones, Scott M. Evans, Blair D. Walker, William J. Worthen, Yves Pierre Gobin
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Patent number: 8066942Abstract: An integrated device for heating and oxygenating blood in an extracorporeal blood circuit, comprising a shell-and-tube heat exchanger module provided with a coupling to a blood supply line and with two couplings respectively for the intake and discharge of the water designed to exchange heat with the blood; ports are also provided for the passage of the blood toward an oxygenator module of the hollow-fiber type which is located at the peripheral region of the heat exchanger and is provided with a coupling to a blood discharge line; the device further comprises means adapted to direct the flow of blood along a turbulence-free path and with optimum distribution within the two modules.Type: GrantFiled: February 26, 2007Date of Patent: November 29, 2011Assignee: Eurosets S.r.l.Inventors: Nicola Ghelli, Edgardo Costa Maianti, Roberto Balanzoni
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Publication number: 20110270147Abstract: A method of manufacturing a bundled mat construction for an extracorporeal blood circuit heat exchanger includes attaching a leading edge of a first capillary tube mat segment to a first side of a mandrel. A leading edge of a second capillary tube mat segment is attached to a second side of the mandrel. The first side is diametrically opposite the second side. The mandrel is rolled relative to the mat segments to generate a bundled mat construction. Radial layers of the bundled mat construction are symmetrical relative to a central axis of the mandrel.Type: ApplicationFiled: January 27, 2011Publication date: November 3, 2011Applicant: Medtronic, Inc.Inventors: Kevin Lauber, Robert Olsen, Mark Wendler, Al McLevish, Chris Plott
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Patent number: 8034235Abstract: A dialysis system includes: a water purification unit; a dialysate generation unit configured to use water purified by the water purification unit; a dialysate delivery unit configured to deliver dialysate prepared by the dialysate generation unit; a supplemental power source; a first electrical connection configured to electrically connect a branch power source with at least one of the water purification unit, the dialysate generation unit and the dialysate delivery unit; and a second electrical connection configured to electrically connect the supplemental power source with at least one of the water purification unit, the dialysate generation unit and the dialysate delivery unit.Type: GrantFiled: February 14, 2008Date of Patent: October 11, 2011Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Justin Rohde, William W. Han
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Patent number: 8021353Abstract: A connector assembly for a heat exchanger has a fitting and a mount to which the fitting couples. The fitting has an elongate body having a proximal portion and a distal portion. At the proximal portion there is a crossbar, and at the distal portion there are an inlet and an outlet that protrude away from the body. Two wings extend from the body in a direction opposite to that of the inlet and outlet. There is formed on each of the wings a locking protrusion. The mount has a top portion where there is a groove dimensioned to accept the crossbar of the fitting. A longitudinal channel is formed orthogonal to the groove in the mount. Two sidewalls extend from the mount each for accepting a corresponding one of the wings, when the fitting is coupled to the mount. Apertures are provided at the sidewalls at the wings.Type: GrantFiled: March 17, 2009Date of Patent: September 20, 2011Assignee: Smiths Medical ASD, Inc.Inventors: Eric Andersen, David Baker, Gregory Hughes, Liam O'Shea, Gary Searle
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Patent number: 8012116Abstract: We have developed a novel method of brain surface dialysis that reduces intracranial pressure and modifies movement of extracellular fluid in a rat model of brain injury. A chamber with a semipermeable membrane at the site of brain contact is perfused with a hyperosmolar solution (e.g. 15% dextran, inulin, hydroxyethyl starch). It is also capable of providing local brain cooling. In principle, osmotic forces draw water and small molecules from the injured brain into the dialysis chamber thereby reducing brain swelling. The dialysate does not move into the brain.Type: GrantFiled: August 18, 2008Date of Patent: September 6, 2011Inventors: Marc Ronald Del Bigio, Alexander Viktor Shulyakov
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Patent number: 7988665Abstract: An infusion fluid heating apparatus applicable to various types of infusion tube with different length dimensions includes a front-side tube fitting groove or a rear-side tube fitting groove formed on one of surfaces of a heating plate that receives an infusion tube in a first length between an inlet opening and an outlet opening open at the end surfaces of the heating plate. The groove also receives the infusion tube in a second length shorter than the first length. Therefore, the groove uses the second length for a relatively short infusion tube, capable of heating the tube appropriately and achieving high versatility. In addition, the tube fitting groove uses the first length for an infusion bag with a relatively long infusion tube, capable of heating the tube appropriately and increasing the maximum infusion fluid flow.Type: GrantFiled: May 10, 2006Date of Patent: August 2, 2011Inventor: Genshirou Ogawa
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Publication number: 20110144557Abstract: A dialysis fluid system includes an instrument including a pump actuator and a fluid heater, and a dialysis fluid cassette. The dialysis fluid cassette includes a rigid portion defining a pumping section for operation with the pump actuator and a heating section for operation with the fluid heater. The heating section includes a dialysis fluid inlet, a dialysis fluid outlet, and a dialysis fluid heating area located between the fluid inlet and the fluid outlet, the heating section further includes an air separation chamber for collecting air separated from the dialysis fluid.Type: ApplicationFiled: February 18, 2011Publication date: June 16, 2011Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.Inventors: Robert W. Childers, Donald D. Busby, Michael E. Hogard, Michael R. Prisco, Atif M. Yardimci, James C. Laird
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Patent number: 7942842Abstract: The invention relates to an apparatus and a method for the treatment of the blood in a Continuous Renal Replacement Therapy, using a machine which comprises: —connecting means from and to respective blood vessels of a patient; —blood processing means comprising a pump; —means for adding drugs or other therapeutic substances to the blood being treated; —means for feeding refill liquid into the blood; —blood filtration means, cascade-connected to one another by relative conduits, said conduits and said connecting means defining a blood path; wherein the blood to be treated passes through an oxygenating device which comprises an oxygenating membrane and is located upstream from said blood filtration means and downstream from said blood processing means, so that the blood is treated by said oxygenating membrane without the intake pressure along the portion upstream from the blood pump; and wherein the blood is pumped downstream from the connecting means to the oxygenating device at a flow rate of about 280-300 mlType: GrantFiled: March 6, 2008Date of Patent: May 17, 2011Assignee: Freeview Ventures LLCInventor: Florenziano Della Torre
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Patent number: 7892423Abstract: A dialysis system includes a first fluid heater, a second fluid heater, and a logic implementer configured to synchronize the duty cycles of the first and second heaters so that (i) power is not supplied to the first heater when power is supplied to the second heater and (ii) power is not supplied to the second heater when power is supplied to the first heater.Type: GrantFiled: February 14, 2008Date of Patent: February 22, 2011Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Justin Rohde, William W. Han
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Publication number: 20110040229Abstract: The subject invention provides an improved bypass circuit for use in adult and especially pediatric cardiac surgery. The auto regulating capability of this circuit design simplifies its operation and combines the benefits of both VAVD and KAVD systems while eliminating the need for multiple blood pumps. Advantageously, this system occupies less space than existing systems, requires the use of less blood, reduces the contact between blood and tubing, reduces damage to blood cells, eliminates the need for multiple blood pumps and also reduces the incidence of gaseous emboli.Type: ApplicationFiled: August 9, 2010Publication date: February 17, 2011Inventors: Robert L. Hannan, Jorge W. Ojito, Redmond Paul Burke
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Publication number: 20110004141Abstract: A method for determining the recirculation in a fistula and/or the cardiopulmonary recirculation part during an extracorporeal blood treatment is disclosed, where the blood to be treated flows in an extracorporeal blood circuit through a blood chamber of a dialyzer split by a semi-permeable membrane into the blood chamber and a liquid chamber, and dialysis liquid flows in a dialysis liquid path through the dialysis liquid chamber of the dialyzer. A device for determining the recirculation in a fistula and/or the cardio-pulmonary recirculation part, and a blood treatment device including such a device are also disclosed. The method and device are based on the fact that the sum of the fistula recirculation and the cardiopulmonary recirculation part, i.e. the total recirculation, is determined for two blood flow rates which differ from each other. The fistula recirculation and/or the cardiopulmonary recirculation part are then determined from the recirculation for the two blood flow rates.Type: ApplicationFiled: November 22, 2007Publication date: January 6, 2011Inventors: Wei Zhang, Elke Schulte, Christoph Bardorz
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Patent number: 7857781Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.Type: GrantFiled: May 16, 2005Date of Patent: December 28, 2010Assignee: Zoll Circulation, Inc.Inventors: Wayne A. Noda, Mike L. Jones, Scott M. Evans, Blair D. Walker, William J. Worthen, Yves Pierre Gobin
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Patent number: 7842001Abstract: An automatic priming method in which an arterial-side chamber is maintained in a normal position during priming, as in a case of dialysis treatment, and in which forward and backward rotations of a blood pump are employed, and a speed of rotation, in particular, backward rotation, is adjusted to be low, so that air or the like is reliably prevented from entering a dialyzer. The priming method for use in a blood purification circuit in which priming is conducted by supplying physiological saline into a circulation circuit formed by connecting an arterial blood circuit with a venous blood circuit includes filling the venous blood circuit with a priming solution (physiological saline), discharging the priming solution for cleaning the arterial blood circuit, conducting a treatment in a direction opposite to the overflow step, which may be followed by a forward direction re-circulation step, and re-circulating in a forward direction.Type: GrantFiled: January 6, 2006Date of Patent: November 30, 2010Assignee: JMS Co.Inventors: Katsunori Masaoka, Takashi Doi, Kaoru Kushiyama
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Publication number: 20100274170Abstract: Disclosed is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit. The apparatus has an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus. The apparatus comprises: a core that is substantially centrally located in the apparatus and to which blood from a patient can be supplied through the inlet; a heat exchanger comprising a plurality of heat transfer elements that are arranged around the core and between which blood from the core can move radially outward; and an oxygenator comprising a plurality of gas exchange elements that are arranged around the heat exchanger and between which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.Type: ApplicationFiled: April 23, 2009Publication date: October 28, 2010Inventors: Walt L. Carpenter, Robert W. Olsen, Michael J. Hobday, Alford L. McLevish, Christopher J. Plott, Roderick E. Briscoe, Patrick J. Cloutier, Anil Thapa, Ming Li, Kevin McIntosh, Ken Merte
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Patent number: 7819835Abstract: An IV pole mountable, therapeutic infusate processing device is incorporated into a hypothermia system to receive therapeutic fluid(s), such as normal saline, peritioneal dialysis solution, or other crystalloid solution, to heat such therapeutic fluid(s) a few degrees centigrade above normal body temperature and to direct the resulting heated infusate to and through a selected anatomical portion of a patients body to raise the temperature of that body portion so as to affect any cancerous or other tumors that may be located therein. The processing device is provided with touch screen controls and visual indicators to facilitate its proper use; while the system further includes temperature and pressure sensors to monitor the hyperthermia processing to insure patient safety.Type: GrantFiled: August 7, 2007Date of Patent: October 26, 2010Assignee: Belmont Instrument CorporationInventors: John Landy, Michael Gildersleeve, Yeu Wen Peter Tseng
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Patent number: 7789846Abstract: Systems and methods for selective cooling of a target site include a catheter having a supply lumen and a delivery lumen, with inlet and exit ports. Blood is withdrawn from the supply lumen and cooled or heated in a control unit. The treated blood is sent to the targeted area via delivery lumen. The supply lumen can act as an insulator for the delivery lumen.Type: GrantFiled: January 25, 2005Date of Patent: September 7, 2010Assignee: Thermopeutix, Inc.Inventors: Ronald J. Solar, Glen Lieber
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Publication number: 20100204634Abstract: Devices, methods, and assemblies for perfusion therapy including cerebral perfusion therapy such as those for use in the treatment of acute ischemic stroke. The treatment includes delivery of blood to or about the vicinity of a thrombus site.Type: ApplicationFiled: February 8, 2010Publication date: August 12, 2010Inventors: Blaise Baxter, Thomas Devlin, Christian Devlin
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Publication number: 20100179466Abstract: Methods for selective cooling or heating of a target site in the human body include a catheter having a supply elongated element and a delivery elongated element, with inlet and exit ports. Blood is withdrawn from the supply elongated element and cooled or heated in a control unit. The treated blood is sent to the targeted area via delivery elongated element. The supply elongated element can act as an insulator for the treated blood in the delivery elongated element.Type: ApplicationFiled: March 25, 2010Publication date: July 15, 2010Inventors: RONALD J. SOLAR, Glen Lieber
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Patent number: 7753869Abstract: A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50-75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient's cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.Type: GrantFiled: April 24, 2007Date of Patent: July 13, 2010Assignee: Hemavation, LLCInventors: Alan A. Davidner, Kimberly A. Walker, Scott R. Mallett
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Patent number: 7749435Abstract: An oxygenator which helps avoid bubbles in the blood from being discharged through the blood outlet port of the oxygenator includes a housing, a hollow fiber membrane bundle in the housing and formed by a multiplicity of hollow fiber membranes serving for gas exchange, gas-inlet and gas-outlet ports communicating with gas passages of the hollow fiber membranes, and a blood-inlet and blood-outlet ports. A filter member is provided on a side closer to the blood outlet port of the hollow fiber membrane bundle and serves to catch bubbles in blood. The blood outlet port projects from the housing and a passage enlargement is provided in a vicinity of the end of the blood outlet port closer to the housing and having an increased passage cross-sectional area. The blood passed the filter member is allowed to reach the blood outlet port by being decelerated in the passage enlargement.Type: GrantFiled: January 19, 2007Date of Patent: July 6, 2010Assignee: Terumo Kabushiki KaishaInventors: Mitsuaki Ogihara, Hidetaka Nakayama, Kazuhiro Mizoguchi
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Patent number: 7722839Abstract: An apparatus and method are provided to rapidly thaw and heat frozen bags of biological materials, such as plasma. The apparatus has a hollow bladder having a flexible wall that is placed in contact with the bag. A circulation system draws fluid from a reservoir and fills the bladder with the fluid. The circulation system also drains fluid from the bladder. A heater in the reservoir heats the fluid before the fluid enters the bladder. As heated fluid flows through the bladder, heat is transferred through the bladder wall to the plasma bag to thaw the biological material. The bladder wall expands against the plasma bag as the bladder fills with fluid, and contracts from the plasma bag as the bladder is drained. The expansion and contraction of the bladder wall agitates the plasma bag and biological material to accelerate the thawing process.Type: GrantFiled: October 10, 2002Date of Patent: May 25, 2010Assignee: Cytotherm, L.P.Inventor: Roman Kuzyk
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Publication number: 20100114003Abstract: A method and device for reducing blood coagulation in the circuit of a device for substitution of the kidney function wherein, prior to the input in the device for substituting the kidney function, the blood which left the patient's body is cooled down to a temperature in the range 10° C. to 30° C. and, as the blood passes the device for substitution of the kidney function, that blood is warmed up to a temperature at least near to the body temperature and then it is returned in the patient's body.Type: ApplicationFiled: January 22, 2009Publication date: May 6, 2010Applicant: Univerzita Karlova v PrazeInventors: Jirí Ruzicka, Zdena Petránková, Jirí Benes, Lukás Bolek, Ales Krouzecký, Roman Sýkora, Martin Matejovic
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Publication number: 20100114004Abstract: A heat exchanger includes a plurality of tubes 2 through an inner cavity of which a heat-transfer medium liquid flows, a sealing member 6 that seals the plurality of tubes 2 while exposing both ends thereof, with a blood channel passing outside each of the tubes 2 being formed in a central portion in the axial direction of the tubes, and a housing 5 that accommodates the tubes 2 sealed with the sealing member 6. The heat exchanger further includes a hollow fiber membrane 3 that is formed of a plurality of hydrophobic and gas permeable hollow fibers 4 and that is disposed on at least one of an entrance side and an exit side of the blood channel in the housing 5 so that a liquid flowing through the blood channel passes through the hollow fiber membrane 3. The housing 5 includes openings 10 for exposing open ends of each of the hollow fibers 4 forming the hollow fiber membrane 3 to the outside, and gaps between an inner side of the openings and the hollow fibers 4 are sealed.Type: ApplicationFiled: March 28, 2008Publication date: May 6, 2010Applicant: JMS CO., LTD.Inventors: Minoru Tanaka, Tomokazu Niitsuma, Shigeki Kawarabata, Takashi Matsushita
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Patent number: 7708942Abstract: A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation.Type: GrantFiled: February 12, 2008Date of Patent: May 4, 2010Assignee: Rheoxtech, LLCInventor: Neil J. Thomas
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Patent number: 7704220Abstract: Systems and methods for selective cooling or heating of a target site in the human body include a catheter having a supply elongated element and a delivery elongated element, with inlet and exit ports. Blood is withdrawn from the supply elongated element and cooled or heated in a control unit. The treated blood is sent to the targeted area via delivery elongated element. The supply elongated element can act as an insulator for the treated blood in the delivery elongated element.Type: GrantFiled: January 25, 2006Date of Patent: April 27, 2010Assignee: ThermopeutiX, Inc.Inventors: Ronald J. Solar, Glen Lieber
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Patent number: 7704221Abstract: A rotary valve unit is provided for blending fluid sources to regulate a temperature of fluid flowing to a heat exchange device in an extracorporeal blood perfusion circuit. A valve body includes a valve chamber having a first inlet port, a second inlet port, a first outlet port, and a second outlet port. A wedged-shaped rotary valve is disposed within the valve chamber and is rotatable within the valve chamber for controlling a blending of the cold fluid entering the fluid chamber from the first inlet port and the return fluid entering the fluid chamber from the second inlet port to regulate the desired temperature of fluid provided to the heat exchanger. The wedge-shaped rotary valve is positionable to provide either only cold fluid to the first outlet port, only return fluid to the first outlet port, or blending of the cold fluid and return fluid to the first outlet port.Type: GrantFiled: March 22, 2007Date of Patent: April 27, 2010Assignee: Terumo Cardiovascular Systems, CorporationInventors: Guy C. Mannlein, John M. Adams, David Danielson, Brian M. Boniface
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Publication number: 20100087771Abstract: Provision of a blood purification system comprising a blood purification tubing and a blood purification apparatus particularly suitable for use in continuous hemofiltration in which in the treatment of a patient with renal disease, multiple organ failure, and the like, the amount of water removed from the patient and the amount of supply to the patient can be more accurately controlled, and in which preparation operation is easy. A blood purification system comprising a blood purification tubing and a blood purification apparatus wherein the soft tubes of flow paths connecting a first planar panel and a second planar panel, and the location of the soft tubes are selected to satisfy a formula of a predetermined condition.Type: ApplicationFiled: February 14, 2008Publication date: April 8, 2010Applicant: ASAHI KASEI KURARAY MEDICAL CO., LTD.Inventors: Atsushi Karakama, Soichiro Okazaki
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Patent number: 7686777Abstract: An in-vitro blood plasma lipids filtering method includes the following steps: separating out the blood plasma from the blood collection; flushing a filtering device with saline solution; controlling the pressure of the separated blood plasma; passing the blood plasma to the filtering device for filtering out lipids; controlling the temperature of the filtered blood plasma; and feeding the blood plasma back to the blood. The method is clearly effective and accurate, quick response indication, securer and safer, more tolerant, and the treatment time is short.Type: GrantFiled: February 28, 2005Date of Patent: March 30, 2010Assignee: Shanghai Jiangxia Blood Technology Co., Ltd.Inventors: Heping Huang, Siukwan Chang
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Patent number: 7682327Abstract: The present invention provides a heart-lung machine which can be carried by one person and can be used independently from an external power supply, consisting of at least three modules (1, 2, 3), wherein a first module (1) contains the blood circulating elements which are necessary for the function of a heart-lung machine, a second module (2) contains a pump drive (9) and an electronic measuring equipment and a control logic (11) and a third module (3) contains the programming unit (14), whereas the second unit is separably connected to the first and the third module.Type: GrantFiled: May 6, 2004Date of Patent: March 23, 2010Assignee: Lifebridge Medizintechnik AGInventor: Karsten Kirchhof
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Patent number: 7656393Abstract: An electronic device has a display and has a touch sensitive bezel surrounding the display. Areas on the bezel are designated for controls used to operate the electronic device. Visual guides corresponding to the controls are displayed on the display adjacent the areas of the bezel designated for the controls. Touch data is generated by the bezel when a user touches an area of the bezel. The device determines which of the controls has been selected based on which designated area is associated with the touch data from the bezel. The device then initiates the determined control. The device can have a sensor for determining the orientation of the device. Based on the orientation, the device can alter the areas designated on the bezel for the controls and can alter the location of the visual guides for the display so that they match the altered areas on the bezel.Type: GrantFiled: June 23, 2006Date of Patent: February 2, 2010Assignee: Apple Inc.Inventors: Nick King, Duncan Kerr, Paul Herbst, Steven P Hotelling
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Patent number: 7588549Abstract: A waterless blood heater/cooler device directly controlling temperature of blood flowing through an extracorporeal blood circuit. A thermoelectric module is coupled to a supply voltage to generate a temperature difference. A heat exchanger cassette comprising a core and first and second laminar flow guides is in thermal contact (directly or indirectly) with the thermoelectric module. The cassette has a plurality of tubes for carrying parallel channels of the blood. The first and second laminar flow guides provide an inlet and an outlet for coupling to the extracorporeal blood circuit and respective intermediate chambers for receiving respective ends of the tubes in order to guide the blood to and from respective tubes in a substantially laminar flow.Type: GrantFiled: August 3, 2006Date of Patent: September 15, 2009Assignee: Terumo Cardiovascular Systems CorporationInventor: Rolando A. Eccleston
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Patent number: 7544300Abstract: A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration.Type: GrantFiled: July 7, 2005Date of Patent: June 9, 2009Assignee: NxStage Medical, Inc.Inventors: James M. Brugger, Jeffrey H. Burbank, Brian C. Green
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Patent number: 7534221Abstract: Endovascular intervention methods entail creating a temporary capillary block in the vasculature of at least a portion of a patient's organ, such as a hemisphere of the patient's brain, the capillary block essentially blocking blood flow through capillaries in the portion of the patient's organ, and performing the endovascular intervention. Distal embolism protection devices include a blood pump and at least one of a centrifuge element, a dialysis element, a cooling element, and a filtration element. The blood pump is generally capable of drawing blood from a patient's vein, circulating the blood through each of the elements so that a characteristic of a blood component may be manipulated therewith, and perfusing the modified blood into a patient's artery. A capillary block is thereby created in the vasculature of at least a portion of a patient's organ with manipulated blood components.Type: GrantFiled: May 24, 2004Date of Patent: May 19, 2009Assignee: The Trustees of Columbia University in the City of New YorkInventor: John Pile-Spellman
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Patent number: 7520862Abstract: A method for evaluating cerebrospinal fluid (CSF) flow rate in a CSF shunt applied to a patient for transmitting the CSF between first and second locations of the patient includes applying temperature sensors to the CSF shunt for determining a flow rate of the CSF through the shunt to provide a determined CSF flow rate and applying an error correction sensor to the patient for providing an error correction signal. The determined CSF flow rate is adjusted in accordance with the error correction signal to provide a corrected CSF flow rate. The sensor can be a temperature sensor such as a thermistor. The CSF is cooled and a temperature value of the CSF is measured in accordance with the cooling. A time value is determined in accordance with the temperature value and the CSF flow rate is determined in accordance with the time value.Type: GrantFiled: February 3, 2004Date of Patent: April 21, 2009Assignee: Neuro Diagnostic Devices, Inc.Inventor: Samuel Neff
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Patent number: 7488302Abstract: A device that allows for serial (time) use of clean blood filters during the use of a heart lung machine. The device is comprised of a series of filters and a switching mechanism that allows the new filter to be placed in the blood flow pathway while at the same time removing the old (previous) filter. A clean filter is always available, and filters for specific components of blood or those able to bind and remove specific biochemicals can be used.Type: GrantFiled: March 28, 2005Date of Patent: February 10, 2009Inventors: Robert Helm, Richard Herink
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Publication number: 20090012655Abstract: A dialysis fluid heating system includes a dialysis fluid heater; a dialysis fluid carrying element in operable communication with the dialysis fluid heater to heat a dialysis fluid; and a logic implementer configured to control the heater using (i) a heater input determined from a dialysis fluid temperature delta and a dialysis fluid flowrate, and (ii) a potential adjustment of the temperature delta using a measured dialysis fluid outlet temperature.Type: ApplicationFiled: July 5, 2007Publication date: January 8, 2009Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.Inventors: Richard Kienman, Jennifer Lindsay, Gideon Hecht, Rodolfo Roger
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Patent number: 7473237Abstract: An apparatus and method for automatically retroperfusing a coronary vein. The apparatus includes an intraluminal graft having a tubular body extending between a proximal end and a distal end. The proximal end is for fluidly connecting to an artery to automatically supply retrograde blood for retroperfusion. The tubular body and the distal end are extendable into a vein that is fluidly connected with the coronary vein to be retroperfused. The distal end includes an expandable stent for securing the distal end in the coronary vein.Type: GrantFiled: January 5, 2006Date of Patent: January 6, 2009Assignee: The Cleveland Clinic FoundationInventors: Jose L. Navia, Jose Antonio Navia, Jorge Luis Jordana, Ji-Feng Chen
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Patent number: 7458952Abstract: A completely integrated cardiopulmonary bypass system includes a common casing provided with a reservoir, a venous air trap, oxygenator, heat-exchanger and a pump. This totally integrated system provides for volume sequestration and for bypassing the reservoir without use of a shunt. The system also provides for open or closed circuit operation, thereby permitting the volume sequestration. The closed circuit operation has a venous air trap for air removal, thus retaining the safety features of both open reservoir and closed-venous air trap systems.Type: GrantFiled: November 14, 2005Date of Patent: December 2, 2008Inventor: Venkataramana Vijay
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Patent number: 7455812Abstract: A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation.Type: GrantFiled: June 16, 2004Date of Patent: November 25, 2008Assignee: Rheoxtech, LLCInventor: Neil J. Thomas
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Publication number: 20080031773Abstract: A waterless blood heater/cooler device directly controlling temperature of blood flowing through an extracorporeal blood circuit. A thermoelectric module is coupled to a supply voltage to generate a temperature difference. A heat exchanger cassette comprising a core and first and second laminar flow guides is in thermal contact (directly or indirectly) with the thermoelectric module. The cassette has a plurality of tubes for carrying parallel channels of the blood. The first and second laminar flow guides provide an inlet and an outlet for coupling to the extracorporeal blood circuit and respective intermediate chambers for receiving respective ends of the tubes in order to guide the blood to and from respective tubes in a substantially laminar flow.Type: ApplicationFiled: August 3, 2006Publication date: February 7, 2008Inventor: Rolando A. Eccleston
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Patent number: 7278981Abstract: A disposable cartridge for use in extracorporeal blood perfusions systems that have a control unit for controlling the flow of fluids. The cartridge has a housing defining a plurality of internal passageways that connect to a cardiopulmonary circuit, a cardioplegia circuit and a suction circuit. The cartridge may be fitted with one or more of a bubble trap, a filter, and a valve.Type: GrantFiled: May 17, 2005Date of Patent: October 9, 2007Assignee: Sorin Group USA, Inc.Inventors: Bruce S. Ellingboe, John J. Kappus, Gary A. Carson, Kevin J. Kollar
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Publication number: 20070217948Abstract: An integrated device for heating and oxygenating blood in an extracorporeal blood circuit, comprising a shell-and-tube heat exchanger module provided with a coupling to a blood supply line and with two couplings respectively for the intake and discharge of the water designed to exchange heat with the blood; ports are also provided for the passage of the blood toward an oxygenator module of the hollow-fiber type which is located at the peripheral region of the heat exchanger and is provided with a coupling to a blood discharge line; the device further comprises means adapted to direct the flow of blood along a turbulence-free path and with optimum distribution within the two modules.Type: ApplicationFiled: February 26, 2007Publication date: September 20, 2007Inventors: Nicola Ghelli, Edgardo Costa Maianti, Roberto Balanzoni