Abstract: A medical treatment system, such as peritoneal dialysis system, may include control and other features to enhance patient comfort and ease of use. For example, a peritoneal dialysis system may include patient line state detector for detecting whether a patient line is primed before it is to be connected to the patient. The patient line state detector can also the ability to detect whether a patient line has been properly mounted for priming. Both patient line presence/absence and fill state can be determined using an optical system, e.g., one that employs a single optical sensor.

Abstract: A method for delivery of a pharmaceutical to a subject includes applying a dermal patch to a subject's skin, wherein the dermal patch comprises a reservoir that stores a pharmaceutical and further comprises at least one hollow needle configured for puncturing the skin, actuating the at least one needle to puncture the subject's skin, and causing at least a portion of the stored pharmaceutical to be released from the reservoir for delivery via a lumen of the hollow needle to the subject.

Abstract: Various techniques for facilitating communication with and across a clinical environment and a cloud environment are described. For example, a method for converting infusion pump messages having one format into standardized dataset messages having another format is described. When a connectivity adapter in the clinical environment detects a new pump protocol, the connectivity adapter may generate a message converter that can convert pump messages into standardized dataset messages. The message converter can be used to convert pump messages into standardized dataset messages. The standardized dataset messages may include information additional data or metadata not included in the pump messages.

Abstract: As an IV infiltration occurs and fluid leaks into surrounding tissues, several physiological changes are expected locally. The systems and methods described herein provide a scalable automated IV infiltration detection device to provide medical staff an early warning of a possible infiltration such that they can respond accordingly. The systems and methods capture the physiological state of the user at or around a peripheral catheter insertion site by incorporating one or more modalities of wearable sensing, processing the data collected from these wearable sensors, detecting the presence of extravascular fluid, and providing an indication to a medical professional.

Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide techniques to implement functionality to receive blood glucose measurements over a period of time. An average of missing blood glucose measurement values may be maintained over a predetermined time period. A count of a number of missing blood glucose measurement values over a period of time may be established. A controller may calculate a divergence of the number of missing blood glucose measurement values over the period of time from the average of missing blood glucose measurements over the predetermined time period. Based on a value of the divergence, a determination that a safety constraint for delivery of insulin is to be reduced. The safety constraint may be reduced by a predetermined percentage. An instruction to deliver an insulin dosage may be generated according to the reduced safety constraint may be forwarded to a wearable drug delivery device.

Abstract: An auto injector is disclosed comprising: a housing, a cartridge receiver, and an ejector member. The cartridge receiver is configured to receive a cartridge containing the medicament. The auto injector further comprises a blocking member coupled to an ejector member. The blocking member is configured to move between a blocking position wherein a connector opening is blocked and a non-blocking position wherein the connector opening is not blocked.

Abstract: Disclosed are techniques and devices that are operable to receive one or a number of generalized parameters of an automated insulin delivery algorithm. An input of at least one generalized parameter corresponding to a user may be used to set one or more of the number of specific parameters of the automated insulin delivery algorithm based on the inputted at least one generalized parameter. Physiological condition data related to the user may be collected. The automated insulin delivery algorithm may determine a dosage of insulin to be delivered based on the collected physiological condition. Signals may be output to cause a liquid drug to be delivered to the user based on an output of the automated insulin delivery algorithm related to the determined dosage of insulin.

Abstract: A data collection device comprises: a first portion having one or more features configured for attaching of the first portion to a dosage knob of an injection device; a second portion rotatably coupled with the first portion, wherein at least part of the second portion is movable axially relative to the first portion; a sensor arrangement configured to detect rotation of the first portion relative to the second portion; and a processor arrangement configured to, based on said detected movement, determine a medicament amount expelled by the injection device, wherein the coupling arrangement is configured to provide a non-permanent coupling between the first portion and the dosage knob of the injection device.

Abstract: Methods, computer-readable media, and systems for providing disease management. In one implementation, a system develops a treatment recommendation for a patient based on patient data. The system may receive patient data, execute a basic model of the physiological system of the patient to generate a modified model for the patient based on the patient data, perform a statistical analysis of the patient data to detect data excursions of the parameter values; use the modified model to determine factors causing the data excursions; and use the model to develop a treatment recommendation to ameliorate negative effects of the disease.

Abstract: A medication delivery monitoring device is disclosed. The device includes a user interface configured to receive input information, and a sensor configured to measure a plurality of fluid state parameters of a fluid delivery channel through which the medication is delivered by a vascular access device (VAD) to an infusion site region of the patient. The device also includes a processor configured to determine a state of the infusion site region based on the plurality of measured fluid state parameters and the input information, and an output device configured to provide a communication regarding the state of the infusion site region. Methods and computer-readable mediums for monitoring medication delivery are also disclosed.

Abstract: Provided is a system for delivering and recording a dose of a medicament to a patient. Also provided is a method of administering a medicament to a patient. Additionally provided is a method of tracking usage of a medicament by a patient through a pen.

Abstract: Systems, and methods relate to a medical device receiving a treatment parameter operating point within a first operating region defined by a first set of operating points for which automatic incremental adjustment of a parameter in the current operation is permitted. In an illustrative example, incremental adjustment may use artificial intelligence based on patient feedback and sensor measurement of outcomes. Some exemplary devices may receive a request to alter the current treatment parameter operating point to a second treatment parameter operating point outside the first operating region and in a second operating region in a known safe operation zone, bounded by a known unsafe zone unavailable to the user. In the second operating region, some examples may restrict the step size of incremental adjustments requested by the user. Data may be collected for cloud-based analysis, for example, to facilitate discovery of more effective treatment protocols.

Abstract: A wearable infusion pump allows a user to insert a program key into a housing of the pump to select a continuous dosage rate. Program keys are shaped to close contacts on a printed circuit board within the housing to communicate the selected dosage rate to a microprocessor. In this way, a single disposable pump, sold with one Stock keeping unit (SKU), can be used to deliver a plurality of dosage rates. The disposable pump is provided with an on-board display and a one-button on-board user operable control. In preferred embodiments, the infusion pump according to the invention may be used for continuous delivery of insulin in management of Type II diabetes.

Abstract: Methods, systems, and devices are disclosed for administering a medicament to a patient. In one aspect, a system includes an injection pen device in wireless communication with a mobile communication device. The injection pen device includes a housing including a chamber to encase a cartridge containing medicine, a dose setting and dispensing mechanism to set the mechanism to dispense a particular dose of the medicine from the loaded cartridge, a sensor unit to detect a dispensed dose based on positions and/or movements of the dose setting and dispensing mechanism, and an electronics unit in communication with the sensor unit to process the detected dispensed dose and time data associated with a dispensing event and to wirelessly transmit the dose data to a user's device. The mobile communication device provides a software application to provide the user with health information using the processed dose data.

Abstract: The present disclosure relates to a dose detection system and method for a medication delivery device. The dose detection system may include a dosing component attached to an actuator and rotationally and axially moveable relative to a coupling component attached to a dose setting member. The dose detection system may further comprise a module including an electronic sensor operative to detect a relative rotation of the coupling component and the dosing component to detect a dose delivered by the medication delivery device.

Abstract: A system and method for promoting, tracking, and assessing mental wellness. The method includes receiving an entry from a subject user, the entry including an input and a mood indicator, storing the entry in within a set of entries, the set including at least two entries received over a period of time, and determining a presence of at least one marker in the input of each entry within the set. The method further includes analyzing the set of entries for occurrences of markers or sequences of markers and alerting a supervisory user if the occurrences of markers or sequences of markers exceed a predetermined threshold. The method further includes associating contextual content from a supervisory user to an entry, the contextual content including a note, an attachment, a form, and/or a flag. The system includes a platform for accessing, managing, and storing data and analytics for implementing the method.

Abstract: An electronic module for a modular patient care system is disclosed. The electronic module can include a housing having an attachment side configured to releasably attach to an adjacent electronic module. A latch mechanism can be configured to engage a catch member on the adjacent electronic module to secure the attachment side to the adjacent electronic module. An electrical connector positioned on the attachment side can be configured to electrically connect to an adjacent electrical connector on the adjacent electronic module. A sensor coupled to the housing can be configured to detect movement of the latch mechanism indicative of at least one of engagement or disengagement of the latch mechanism from the adjacent electronic module.

Abstract: An analyte sensor system may include a first communication circuit configured to transmit a wireless signal in a first communication mode and a second communication mode, and a processor, wherein the processor determines whether a first condition is satisfied, the first condition relating to the sensor signal or to communication by the first communication circuit, and shifts the system to a second communication mode responsive to the first condition being satisfied.

Abstract: A sensor system capable of detecting tissue counter pressure from patients that utilize infusion pumps to administer their medication is provided. Embodiments include a retrofitted piece that is placed between the user's infusion set and pump, as well as a “smart” infusion set configured for measuring characteristics of a fluid traveling therethrough. Hardware is provided that couples with the sensor to store, analyze, and compare data to distinguish between normal and non-normal injection/infusion profiles. An alert system notifies the user of a malfunction within the pump, within the infusion set, or at the injection/infusion site.

Abstract: The device comprises of a housing defining a channel there through, a torsion-spring based clamping mechanism, a drop sensor connected with circuitry, a manual infusion fluid regulation mechanism and a power source. An upper portion of the channel accommodates at least a part of a drip chamber and a lower portion of the channel accommodates at least a part of infusion tubing. The clamping mechanism comprises of one or more torsion springs and is configured for engaging and holding drip chamber and can be adjusted according to the drip chamber diameter. The drop sensor and the circuits coupled with it are configured for detecting real time drop rate of the infusion fluid. The regulation mechanism comprises of a drivable pinching element for sliding into the channel and compressing the infusion tubing thereby regulating the flow of the infusion fluid through the infusion tubing.

Abstract: Provided is an extended use self-contained, wearable medical device. The device is preferably configured with an infusion deployment mechanism for variably inserting and retracting an infusion needle to different depths, or completely retracting the infusion needle from the infusion site and then re-inserting the infusion needle after a predetermined period of time, throughout an infusion cycle for extending the viability of the infusion site. Another embodiment comprises dual needle deployment mechanisms which may also variably insert and retract the infusion needles. A flow sensor is preferably provided for detecting the stoppage of flow through the infusion cannula and signaling the needle deployment mechanism to attempt infusion at a different depth or to deploy a second infusion needle. A re-fillable reservoir assembly is preferably provided for supplying a drug over the extended use of the device.

Abstract: Embodiments of the present disclosure enable a user-wearable infusion pump that may have a limited user interface including no display to be paired with a remote control device that can include a remote consumer electronic device such as a smartphone and/or a dedicated remote controller.

Abstract: Disclosed is a flow detector (1) for releasable coupling with a flow channel (20) in a channel coupling area and detecting a flow of liquid drug in the flow channel (20), the flow detector including: an upstream thermoelectric element (10a) and a downstream thermoelectric element (10b), wherein the upstream thermoelectric element (10a) and the downstream thermoelectric element (10b) are arranged spaced apart from each other and movable independent from each other; an upstream biasing element (15a) and a downstream biasing element (15b), wherein the upstream biasing element (15a) acts on the upstream thermoelectric element (10a), thereby biasing the upstream thermoelectric element (10a) towards the channel coupling area, and the downstream biasing element (15b) acts on the downstream thermoelectric element (10b), thereby biasing the downstream thermoelectric element (10b) towards the channel coupling area independently from the upstream biasing element (15a).

Abstract: A data collection device comprises: a first portion having one or more features configured for attaching of the first portion to a dosage knob of an injection device; a second portion rotatably coupled with the first portion, wherein at least part of the second portion is movable axially relative to the first portion; a sensor arrangement configured to detect rotation of the first portion relative to the second portion; and a processor arrangement configured to, based on said detected movement, determine a medicament amount expelled by the injection device, wherein the coupling arrangement is configured to provide a non-permanent coupling between the first portion and the dosage knob of the injection device.

Abstract: A dripping detection apparatus includes a cylindrical drip cylinder into which a nozzle is inserted from an upper side and that receives inside a liquid droplet dripping from a lower end of the nozzle, and a photo interrupter that has equal to or more than one light emitting element emitting light and equal to or more than two light receiving elements receiving the light, wherein the equal to or more than one light emitting element and the equal to or more than two light receiving elements are arranged at opposing or substantially opposing positions with the drip cylinder interposed between the elements and equal to or more than two light paths connecting the equal to or more than one light emitting element to the equal to or more than two light receiving elements are located at a lower side relative to the lower end of the nozzle.

Abstract: Systems and methods provide real-time optical monitoring and control of well operations using digital cameras and image analysis. The systems and methods deploy one or more digital cameras in place of or in addition to conventional sensors to capture images of a well pump during well operations. The images may then be analyzed using image analysis algorithms and programs to measure a height, position, shape, and other measurements for certain components of the well pump relative to previous images. These image-based measurements may then be used to determine various operational parameters, such as pump speed, pump load, and other operational parameters. The operational parameters may then be processed by a pump control system to optimize pump operations based on the operational parameters.

Abstract: An auto injector is disclosed comprising: a housing, a cartridge receiver, and an ejector member. The cartridge receiver is configured to receive a cartridge containing the medicament. The auto injector further comprises a blocking member coupled to an ejector member. The blocking member is configured to move between a blocking position wherein a connector opening is blocked and a non-blocking position wherein the connector opening is not blocked.

Abstract: Methods, devices, and systems may use a kinetic model to determine physiological parameters related to the kinetics of red blood cell glycation, elimination, and generation. Such physiological parameters can be used, for example, to determine a more reliable calculated HbA1c. In another example, a method may comprise: receiving a plurality of glucose levels over a time period; receiving a glycated hemoglobin (HbA1c) level corresponding to an end of the time period; determining at least one physiological parameter selected from the group consisting of: a red blood cell glycation rate constant (kgly), a red blood cell generation rate constant (kgen), a red blood cell elimination constant (kage), and an apparent glycation constant (K), based on (1) the plurality of glucose levels and (2) the HbA1c level; and adjusting a glucose level target based on the at least one physiological parameter.

Abstract: An intradermal fluid delivery device that uses a processor controlled electromechanical delivery mechanism is provided. An air pump pushes fluid containing medication or saline from a fluid compartment through a microneedle array into a person's skin. The processor repeatedly turns the air pump on or off, for the fluid to gradually be injected into the person's skin. The processor may be configured to control the total fluid delivery time as well as the granularity of the fluid delivery. The total fluid delivery time may be set to T, and the time period T may be divided into smaller periods t1 to tn, where the fluid may be administered in a period t1, the fluid delivery may then be stopped for a period t2, followed by another fluid delivery period, etc. The periods t1 to tn may be the same or of different lengths.

Abstract: Inductive identification systems and methods are described. The system may include an inductive detector configured to identify objects having inductive identifiers. An inductive detector may include conductive coils and inductance readout circuitry for measuring an inductance of each coil. An inductive identifier may include a conductive pattern configured to induce a desired inductance in the coils of the inductive detector. An inductive identifier may include a film having openings, each opening configured to be disposed over a corresponding coil to induce differing inductance changes in the corresponding coils. A pattern of inductance values may be determined and used to identify the object. The detector may be implemented in a cassette recess of an infusion pump system. The inductive identifier may be disposed on a pump cassette configured to be received in the cassette recess and identified based on an inductive interaction between the inductive detector coils and the inductive identifier.

Abstract: Therapy device systems, modules, and methods, include memory, one or more processors, in communication with the memory, a plurality of medical therapy devices, a plurality of patient monitoring devices, and a protocol execution module, configured to execute on the one or more processors. The protocol execution module displays a plurality of protocols. The protocol execution module receives a selected protocol, associated with an individual medical therapy device being one of a plurality of medical therapy devices and associated with an individual patient monitoring device being one of a plurality of patient monitoring devices. The protocol execution module executes the selected protocol with the individual medical therapy device.

Abstract: Various techniques for facilitating communication with and across a clinical environment and a cloud environment are described. For example, a method for converting infusion pump messages having one format into standardized dataset messages having another format is described. When a connectivity adapter in the clinical environment detects a new pump protocol, the connectivity adapter may generate a message converter that can convert pump messages into standardized dataset messages. The message converter can be used to convert pump messages into standardized dataset messages. The standardized dataset messages may include information additional data or metadata not included in the pump messages.

Abstract: A method of testing the rotor engagement of a peristaltic pump rotor. The method comprising steps of providing a pump system comprising a peristaltic pump rotor; a tube; a valve; a pressure sensor; a comparator; and a processor. The pressure sensor is configured to monitor the pressure in a fluid in the tube downstream of the peristaltic pump rotor and upstream of the valve. The comparator is configured to continuously monitor the pressure sensor and compare the measured fluid pressure data with a predetermined parameter. The processor is configured to receive a signal from the comparator and generate an alert signal when the measured pressure data falls outside the predetermined parameters.

Abstract: A medicament delivery device for injections or inhalations comprises a supplementary device affixed to it. The supplemental device is provided with an optical system for monitoring a dosage of medicament. The optical system is able to receive reflected and refracted optical images of the dosage value as the optical signals from the medicament delivery device and thus keep a dosage window on the medicament delivery device free for direct monitoring by a user due to changing the transferring of the optical signal direction. The supplemental device is able to analyze, record and display the dosage and the other relevant data on a display and inform the user. The supplemental device is also able to transmit the medicament delivery data to an external device. A method for collecting the medicament delivery data including the medicament dosage information from a dosage setting mechanism and controlling the dosage, recording and displaying the dosage data by the supplemental device on its display is disclosed.

Abstract: The disclosed apparatus, system and method may include at least a surgical fluid container that includes a fluid reservoir capable of containing the surgical fluid and a gas pressure pocket applied to the surgical fluid therewithin; a first external port extending from outside the fluid reservoir into fluid communication with the surgical fluid within the fluid reservoir; and a second external port extending directly from outside the fluid reservoir into the gas pressure pocket.

Abstract: A method of managing insulin includes receiving blood glucose measurements on a computing device from a glucometer. The blood glucose measurements are separated by a time interval. The method includes determining, by the computing device, an insulin dose rate based on the blood glucose measurements and determining a blood glucose drop rate based on the blood glucose measurements and the time interval. The method also includes determining a blood glucose percentage drop based on the blood glucose measurements. The method includes decreasing the time interval between blood glucose measurements by the glucometer when the blood glucose drop rate is greater than a threshold drop rate, and decreasing the time interval between blood glucose measurements by the glucometer when the blood glucose percentage drop is greater than a threshold percentage drop.

Abstract: Embodiments of the present disclosure enable a user-wearable infusion pump that may have a limited user interface including no display to execute and provide feedback on a number of functions. A remote control device having a display can be used to control the infusion pump. The infusion pump can include one or more indicator lights that can be indicate different statuses with different light patterns. The remote control device can include a display screen that provides further information relating to various pump statuses.

Abstract: There is provided a method comprising: computing a target nutritional goal to reach at an end of a time interval based on a real time energy expenditure of a patient, wherein the target nutritional goal comprises a volume to be delivered (VTBD) by the end of the time interval corresponding to a target amount of energy expenditure of the patient over the time interval, computing a target feeding profile defining a target feeding rate for enteral feeding of the patient for reaching the VTBD by the end of the time interval, continuously monitoring the real time energy expenditure, adapting the target nutritional goal and corresponding VTBD to compute a maximum VTBD to reach at the end of the time interval according to the monitoring, and dynamically adapting the target feeding rate and the corresponding target feeding profile for a remaining portion of the time interval for reaching the maximum VTBD.

Abstract: The invention relates to an electronic add-on module which is fitted releasably onto an automatic injection appliance before the start of injection. The add-on module comprises a force sensor for measuring a time-variable axial force component exerted on or transmitted to the attached add-on module by the injection appliance during an injection procedure. The add-on module also comprises a grip or a preferred grip position for gripping and holding the add-on module and the inserted injection appliance. The add-on module can additionally have a microphone for detection of acoustic signals. A state of the injection appliance can be determined by the add-on module solely on the basis of measurements of the axial force sensor, optionally supplemented by microphone measurements. The invention thus affords a straightforward and cost-effective way of monitoring or controlling the correct performance of an injection procedure carried out with an automatic injection appliance.

Abstract: The present disclosure provides a liquid constant temperature heating apparatus, an infusion device and a formula milk preparation device. The liquid constant temperature heating apparatus includes: a heating portion, the heating portion having a heating chamber, and the heating chamber having a liquid inlet and a liquid outlet; a liquid inlet pipe, the liquid inlet pipe being connected with the liquid inlet of the heating portion; a liquid outlet pipe, the liquid outlet pipe being connected with the liquid outlet of the heating portion; a temperature sensor, the temperature sensor being arranged on the liquid outlet pipe and in communication with the heating portion; and a controller, which is in signal connection with the temperature sensor by a signal and configured to control heating of the heating portion according to a measurement result of the temperature sensor.

Abstract: A method, computer program product, and computer system for determining that a user wears a wearable device during one or more time periods. A total amount of time that the user is wearing the wearable device during the one or more time periods may be tracked. The total amount of time that the user wears the wearable device during the one or more time periods may be transmitted to a computing device for display on a user interface.

Abstract: A pump with a controller for adjusting head pressure using a pressure boost is provided. The pressure boost may be dynamically adjusted during a surgical procedure based on the device being used and inflow and/or outflow settings.

Abstract: A database of foods can be employed for configuring delivery of a bolus with an insulin pump. A user of the pump selects one or more foods from the database of foods to form a meal from which the user's carbohydrate intake is calculated. The database of foods can include a number of records associated with food entries.

Abstract: A supplementary device is configured to be attached to a drug delivery device. The supplementary device comprises a non-contact sensor configured to output signals indicative of the position of a moveable component within the drug delivery device. The supplementary device further comprises a processor configured to receive the signals output from the non-contact sensor. This processor is additionally configured to determine, based on the signals, whether the drug delivery device is in a pre-activation state or a post-activation state.

Abstract: An apparatus and system diabetes management.

Abstract: An infusion pump system comprises a pump for infusing a drug into a patient, a storing unit for storing therapy data, drug data, protocol data, profile data, care type data, and feedback data received from said pump and/or other sources including information about particularities of therapies already carried out or currently running, an input unit for selecting therapy data, drug data, profile data, and care type data, an associating unit for associating the selected therapy data, drug data, profile data and care type data provided by said input unit and further adapted to determine based on said association specific protocol data and specific feedback data, wherein said storing unit also stores said association with said specific protocol data and said specific feedback data; and an output unit for outputting said specific protocol data with said specific feedback data.

Abstract: A hydronic distribution system includes self-regulating valves networked together and operable to share valve temperature and valve position information with a microprocessor or other type of controller. The microprocessor runs one or more algorithms that process the temperatures and positions of the valves and then computes a desired speed for one or more variable speed pumps within the system. Controlling the pumps to operate at the desired speed and still maintain the correct amount of process fluid flow needed by the system reduces the overall energy use of the hydronic distribution system, saves on the operational lives of the pumps, and increases system efficiency.

Abstract: A method and apparatus are provided for use in locating a target region which is situated in the body of a subject, for example for the delivery of drugs. The system includes an assembly for controlling the flow of fluid from a fluid reservoir to a conduit, such as a needle. A sensor detects a characteristic indicative of the fluid pressure in the conduit. The system processes data from the sensor to detect the presence of a pulsatile waveform. A controller may control further operation of the system based on information regarding the presence of the pulsatile waveform and features of the waveform, such as amplitude.

Abstract: Embodiments are directed to portable infusion devices, systems, and methods of using the same for dispensing materials. In some cases, the devices, systems and methods may be used for infusing a material such as medicament, e.g., insulin, into a body in need thereof.

Abstract: The invention relates to administration of clinical anesthesia. Particular embodiments provide systems and methods for controlled delivery of a combination of an analgesic agent and a hypnotic agent. More specifically, the invention relates to closed-loop control systems/methods for automatically controlling the administration of a combination of a hypnotic agent and an analgesic agent in a clinical anesthesia setting which incorporate feedback based on one or more indirect measures/indicia of analgesia. The invention further relates to such control systems/methods that account for limitations of such indirect measures/indicia of analgesia.