Sensor Responsive To Body Condition Patents (Class 604/66)
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Patent number: 12042631Abstract: A system and method for monitoring and delivering medication to a patient. The system includes a controller that has a control algorithm and a closed loop control that monitors the control algorithm. A sensor is in communication with the controller and monitors a medical condition. A rule based application in the controller receives data from the sensor and the closed loop control and compares the data to predetermined medical information to determine the risk of automation of therapy to the patient. A system monitor is also in communication with the controller to monitor system, remote system, and network activity and conditions. The controller then provides a predetermined risk threshold where below the predetermined risk threshold automated closed loop medication therapy is provided. If the predetermined risk threshold is met or exceeded, automated therapy adjustments may not occur and user/clinician intervention is requested.Type: GrantFiled: March 16, 2023Date of Patent: July 23, 2024Assignee: ICU Medical, Inc.Inventors: William Kenneth Day, Timothy L Ruchti
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Patent number: 12036011Abstract: A method, an apparatus, and a kit including the apparatus and a fluorescence agent are provided for measuring a time-varying change in an amount of blood in a tissue volume, and include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain a measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent. There is further provided a fluorescence agent for use in the method.Type: GrantFiled: April 27, 2020Date of Patent: July 16, 2024Assignee: Stryker CorporationInventors: Robert W. Flower, Robert Anthony Stead, Arthur E. Bailey
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Patent number: 12023175Abstract: A computer-implemented method improves efficacy of diabetes self-management to obtain a measurement message and/or contextual activity information used to determine a suitable insulin dosage to treat a patient. The method includes simulating a health coach in a natural conversation to obtain a measurement of the patient's blood-glucose level, processing the measured blood-glucose level with a personalized insulin titration algorithm to determine an insulin dosage recommendation, and generating an electronic signal configured to cause a corresponding action to be performed by a computing device.Type: GrantFiled: September 20, 2022Date of Patent: July 2, 2024Assignee: Verily Life Sciences LLCInventors: Nikhil Roy, Miguel Angelo Drumond
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Patent number: 11986649Abstract: Provided are systems, methods, and devices for brain stimulation and monitoring. Brain stimulation may be provided to enhance slow wave and spindle synchrony. Such stimulation may provide increased memory consolidation. Furthermore, brain stimulation modalities may provide enhanced sleep and awakening. For example, transcranial direct current stimulation of the brain stimulation may enhance sleep quality. Moreover, one or more markers characterizing unconsciousness are may be identified based on changes in measured power densities or spectra. Further still, the above described modalities of brain stimulation may be implemented in an open-loop or closed loop manner. Brain state parameters may be generated for building models of the brain based on determined synchrony patterns between slow waves and spindles. The models may be used to determine a mediation procedure for adjusting the intensity of slow wave oscillations to enhance slow wave and spindle synchrony.Type: GrantFiled: December 17, 2020Date of Patent: May 21, 2024Assignee: STIMSCIENCE INC.Inventor: Anantha K. Pradeep
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Patent number: 11986630Abstract: The exemplary embodiments attempt to identify impending hypoglycemia and/or hyperglycemia and take measures to prevent the hypoglycemia or hyperglycemia. Exemplary embodiments may provide a drug delivery system for delivering insulin and glucagon as needed by a user of the drug delivery system. The drug delivery system may deploy a control system that controls the automated delivery of insulin and glucagon to a patient by the drug delivery system. The control system seeks among other goals to avoid the user experiencing hypoglycemia or hyperglycemia. The control system may employ a clinical decision support algorithm as is described below to control delivery of insulin and glucagon to reduce the risk of hypoglycemia or hyperglycemia and to provide alerts to the user when needed. The control system assesses whether the drug delivery system can respond enough to avoid hypoglycemia or hyperglycemia and generates alerts when manual action is needed to avoid hypoglycemia or hyperglycemia.Type: GrantFiled: February 12, 2020Date of Patent: May 21, 2024Assignee: INSULET CORPORATIONInventors: Joon Bok Lee, Ashutosh Zade, Jason O'Connor, Trang Ly, Yibin Zheng, Connor Gullifer, Kyle Grover
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Patent number: 11986627Abstract: The present invention relates to titration and delivery of anesthetic and sedative medications to a subject. Further, the present invention relates to a device and methods for titrating and delivering the medications in a semi-automated or fully automated manner and which can be monitored and controlled remotely. Even still further, the present invention relates to the device that can perform the titration and the delivery of the medications in a manner that minimalizes occlusion and prevents back flow of the medications. More particularly, the present invention relates to the device for the titration and the delivery of the medications using a non-concentric pumping mechanism that gradually or progressively increases and decreases occlusion in a medication delivery line within the pumping mechanism to minimize and/or prevent sudden formation and release of the occlusion in order to provide more steady and continuous flow of the medications through the device to the subject.Type: GrantFiled: October 20, 2020Date of Patent: May 21, 2024Assignee: NeuroWave Systems Inc.Inventors: Stéphane Bibian, Sankar Barua, Tatjana Zikov
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Patent number: 11911595Abstract: Disclosed herein are apparatuses and methods that account for meal announcements in closed loop insulin delivery systems. Rather than simply increasing an insulin delivery rate in response to the meal announcement, the closed loop algorithm can be modified to increase the insulin on board tolerance during eating periods. This approach utilizes the stability of the cascaded loop in the closed loop algorithm to prevent the oscillations in glucose levels that can occur by simply increasing the basal rate.Type: GrantFiled: May 18, 2021Date of Patent: February 27, 2024Assignee: TANDEM DIABETES CARE, INC.Inventors: Thomas R. Ulrich, Virginia S. Lu
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Patent number: 11839742Abstract: An intravenous (IV) device, may include a needle; a catheter coaxially formed around the needle; a fluidic path fluidically coupled to a hollow formed through the needle and catheter; and a printed circuit board (PCB), including: a network interface device; a plurality of sensors operatively coupled to the fluidic path to measure a biological characteristic related to a plurality of patient vitals.Type: GrantFiled: January 15, 2020Date of Patent: December 12, 2023Assignee: Becton, Dickinson and CompanyInventors: Kathryn Willybiro, Jonathan Karl Burkholz, Joseph Spataro, Yiping Ma, Huy Tran, Bart D. Peterson
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Patent number: 11793937Abstract: A method of monitoring depth of muscle relaxation of a patient includes determining a sedative drug effect of one or more sedative drugs on a patient based on at least one of drug delivery information and measured nervous system information. The sedative drug effect is then compared to a sedation criterion and, if the sedative drug effect fulfills the sedation criterion, then a neuromuscular transmission (NMT) monitor is controlled to apply a series of stimulation to a nerve of a patient and muscle responses of the patient are measured to obtain an NMT baseline. A neuromuscular blocking agent (NMBA) notice is then generated on a user interface after obtaining the NMT baseline.Type: GrantFiled: March 25, 2020Date of Patent: October 24, 2023Assignee: GE Precision Healthcare LLCInventor: Mika Olli Kristian Särkelä
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Patent number: 11766194Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration level. The glucose concentration level may be provided to a stored model to determine a state. The guidance may be determined based at least in part on the determined state.Type: GrantFiled: February 6, 2019Date of Patent: September 26, 2023Assignee: Dexcom, Inc.Inventors: Alexandra Elena Constantin, Scott M. Belliveau, Naresh C. Bhavaraju, Jennifer Blackwell, Eric Cohen, Basab Dattaray, Anna Leigh Davis, Rian Draeger, Arturo Garcia, John Michael Gray, Hari Hampapuram, Nathaniel David Heintzman, Lauren Hruby Jepson, Matthew Lawrence Johnson, Apurv Ullas Kamath, Katherine Yerre Koehler, Phil Mayou, Patrick Wile McBride, Michael Robert Mensinger, Sumitaka Mikami, Andrew Attila Pal, Nicholas Polytaridis, Philip Thomas Pupa, Eli Reihman, Peter C. Simpson, Tomas C. Walker, Daniel Justin Wiedeback, Subrai Girish Pai, Matthew T. Vogel
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Patent number: 11707571Abstract: The present disclosure describes a closed-loop fluid resuscitation and/or cardiovascular drug administration system that uses continuous measurements and adaptive control architecture. The adaptive control architecture uses a function approximator to identify unknown dynamics and physiological parameters of a patient to compute appropriate infusion rates and to regulate the endpoint of resuscitation.Type: GrantFiled: April 28, 2022Date of Patent: July 25, 2023Assignee: Autonomous Healthcare, Inc.Inventor: Behnood Gholami
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Patent number: 11621065Abstract: Various aspects described herein relate to presenting drug dispensing information. Data related to a plurality of dispensing events initiated by one or more employees, of an electronic drug dispensing system can be received. A set of dispensing events of the plurality of dispensing events can be determined as constituting possible misappropriation of drugs by the one or more employees. An alert related to the set of dispensing events can be provided based on determining that the set of dispensing events constitute possible misappropriation of drugs.Type: GrantFiled: February 24, 2022Date of Patent: April 4, 2023Assignee: Protenus, Inc.Inventors: Nicholas T. Culbertson, Robert K. Lord, Christopher David Jeschke, Cosme Adrover
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Patent number: 11589796Abstract: The present invention relates to a method and system for calculating eating bites of a user. The method comprises: (a) continuously measuring the electrical properties data of mastication of a user for a predetermined period of time; (b) periodically determining single eating bites according to the data obtained in step (a) through a time interval; (c) periodically storing the bites determined throughout the predetermined period of time, through a time interval.Type: GrantFiled: January 31, 2018Date of Patent: February 28, 2023Inventor: Sivan Kinreich
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Patent number: 11559693Abstract: Techniques for pairing an external device such as a clinician programmer (CP) to an implantable medical device (IMD) are disclosed, which involve use of a remote controller (RC) paired to the IMD. The RC is placed into a CP pairing mode, which acts differently depending on the type of IMD paired to the RC. If the IMD is RF based, the CP pairing mode places the IMD in a pairing mode, thus allowing the CP to connect directly with the IMD via a RF telemetry protocol. If the IMD is magnetic-induction based, the CP pairing mode causes the RC to advertise its presence to the CP, allowing the CP to connect to the RC via the RF telemetry protocol. Because the RC is also paired with the IMD via a magnetic induction telemetry protocol, the RC acts as a passthrough device to allow communications between the CP and the IMD.Type: GrantFiled: September 10, 2021Date of Patent: January 24, 2023Assignee: Boston Scientific Neuromodulation CorporationInventors: Chirag Shah, Peter Yoo
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Patent number: 11510811Abstract: A surgical system comprises a pressurized irrigation fluid source; an irrigation line fluidly coupled to the pressurized irrigation fluid source; a hand piece fluidly coupled to the irrigation line; and a controller for controlling the pressurized irrigation fluid source. The controller controls the pressurized irrigation fluid source based on an estimated flow value modified by a compensation factor.Type: GrantFiled: June 11, 2020Date of Patent: November 29, 2022Assignee: Alcon Inc.Inventors: Mikhail Boukhny, Raphael Gordon, Michael D. Morgan, Gary P. Sorensen
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Patent number: 11455505Abstract: An injection vial and injection vial management system is disclosed, wherein the injection vial is filled with a liquid medicine and signally connected with a blockchain network. The injection vial includes a bottle body and a chipset disposed within the bottle body. The chipset includes an identification label and a blockchain module. The identification label records a manufacturing process, a logistic process and a use process. The blockchain module signal connects to the blockchain network in order to record the manufacturing process, logistic process and use process in the blockchain network.Type: GrantFiled: March 2, 2021Date of Patent: September 27, 2022Assignee: AI Bioelectronic Healthcare Co., Ltd.Inventor: Yen-Yi Ho
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Patent number: 11379090Abstract: A firefighting monitor that has a first section, a second section joined to the first section by a first pivot connection, and a plurality of ball bearings positioned in the first pivot connection between a pair of bearing seats. Wherein, the bearing seats define an arc of contact with each of the plurality of ball bearings, the center of the arc of contact defining a tangent angled with respect to a flow axis defined by the first pivot connection.Type: GrantFiled: September 19, 2019Date of Patent: July 5, 2022Assignee: Elkhart Brass Manufacturing Company, Inc.Inventors: Eric N. Combs, Donald E. Sjolin, Frederic Einstein, Kevin McGuire, Lee R. Jones, John E. McLoughlin, Neocles G. Athanasiades, Kiam Meng Toh, Kyle A. Stoops
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Patent number: 11376361Abstract: A system and method for monitoring and delivering medication to a patient includes a controller that has a control algorithm and a closed loop control that monitors the control algorithm. A sensor is in communication with the controller and monitors a medical condition. A rule base application in the controller receives data from the sensor and the closed loop control and compares the data to predetermined medical information to determine the risk of automation of therapy to the patient. The controller then provides a predetermined risk threshold where below the predetermined risk threshold automated closed loop medication therapy is provided. If the predetermined risk threshold is met or exceeded, automated therapy adjustments may not occur and user/clinician intervention is requested.Type: GrantFiled: June 21, 2018Date of Patent: July 5, 2022Assignee: ICU Medical, Inc.Inventors: Timothy L. Ruchti, Mohammad M. Khair
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Patent number: 11369789Abstract: An embodiment relates to a transdermal drug delivery system comprising a patch comprising a) a cartridge comprising a drug; b) a bio-sensor and a non bio-sensor; c) an active delivery pad comprising an electrode for delivery of the drug into a tissue via iontophoresis; d) a power source of electrical energy connected to the electrode; e) a microcontroller configured to control a release of the drug wherein the patch is attached to the tissue via an adhesive pad, and optionally top of patch is covered with a sheet; wherein the bio-sensor is configured to detect a physiological parameter; wherein the non bio-sensor is configured with a software to control working of the patch.Type: GrantFiled: April 5, 2021Date of Patent: June 28, 2022Inventors: Ishaan Jain, Anjan S. Sesetty, Aditi Gubba, Om G. Desai
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Patent number: 11357446Abstract: Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.Type: GrantFiled: December 4, 2020Date of Patent: June 14, 2022Assignee: Reprieve Cardiovascular, Inc.Inventors: Howard R. Levin, Jim Dillon, Andrew Halpert, Jeffrey Testani
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Patent number: 11344529Abstract: The present invention relates to stable therapeutic compositions of pharmaceutical grade acids and pH buffering agents. The present invention also is directed to methods of treatment for mitochondrial disorders, metabolic conditions, diabetic conditions, and cardiovascular conditions, by administration of compositions of the present disclosure.Type: GrantFiled: October 28, 2019Date of Patent: May 31, 2022Assignee: REVEN IP HOLDCO LLCInventors: Hendrik J. P. van Wyk, Peter B. Lange, James Ervin, Brian D. Denomme, Mariette L. van Wyk, Peter Pacult, Michael A. Volk
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Patent number: 11338087Abstract: The present disclosure describes a closed-loop fluid resuscitation and/or cardiovascular drug administration system that uses continuous measurements and adaptive control architecture. The adaptive control architecture uses a function approximator to identify unknown dynamics and physiological parameters of a patient to compute appropriate infusion rates and to regulate the endpoint of resuscitation.Type: GrantFiled: November 5, 2020Date of Patent: May 24, 2022Assignee: Autonomous Healthcare, Inc.Inventor: Behnood Gholami
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Patent number: 11302433Abstract: An apparatus comprising a pump, an input configured to receive information related to a user, a user interface, and a controller communicatively coupled to the pump, the input, and the user interface. The controller includes a timing module configured to initiate delivery of a drug in time and to adjust delivery according to the received information. Other devices, systems, and methods are disclosed.Type: GrantFiled: April 25, 2019Date of Patent: April 12, 2022Assignee: Tandem Diabetes Care, Inc.Inventors: Michael L. Blomquist, Kevin Kopp, Thomas Alan Savard
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Patent number: 11266334Abstract: Disclosed are methods, apparatuses, etc. for calibrating glucose monitoring sensors and/or insulin delivery systems. In certain example embodiments, blood glucose reference samples may be correlated with sensor measurements with regard to a delay associated with the sensor measurements. In certain other example embodiments, a blood-glucose concentration in a patient may be determined based, at least in part, on one or more probability models, one or more functions for estimating blood-glucose concentrations, and/or blood glucose reference sample-sensor measurement pairs.Type: GrantFiled: February 28, 2018Date of Patent: March 8, 2022Assignee: MEDTRONIC MINIMED, INC.Inventors: Anirban Roy, Barry Keenan, Michael Kremliovsky
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Patent number: 11241166Abstract: A body-mountable device is provided to facilitate communication, via in-body electrical signals transmitted via electrodes of the body-mountable device into fluid of the body, with a smart pill located in a gastrointestinal tract of a body to which the body-mountable device is mounted or with some other device located within the body. The body-mountable device can be a contact lens or other eye-mountable device such that the electrodes of the eye-mountable device can transmit in-body electrical signals via tear fluid. The body-mountable device could transmit a command to the smart pill to dispense a drug into the body. The smart pill could transmit, via in-body electrical signals, an indication of a detected property of the gastrointestinal tract to the body-mountable device. A latency of transmission of signals between the body-mountable device and the smart pill could be used to determine the location of the smart pill within the gastrointestinal tract.Type: GrantFiled: December 29, 2016Date of Patent: February 8, 2022Assignee: Verily Life Sciences, LLCInventor: Shungneng Lee
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Patent number: 11241542Abstract: A sensor device removably attachable to a drug delivery device includes a sensing arrangement arranged within the sensor device and circuitry configured to process signals provided by the sensing arrangement. The sensing arrangement is configured such that, when the sensor device is attached to the drug delivery device, the sensing arrangement is operable to read encoded information present on a rotatable component internal to the drug delivery device and that is able to be sensed through a window or aperture of the drug delivery device, and is operable to sense through the window or aperture at least a part of a drive mechanism of the drug delivery device. The circuitry is configured to determine information relating to a set dose, and to determine information relating to whether the drug delivery device is in a dose setting mode or whether the device is in a dose delivery mode.Type: GrantFiled: March 19, 2020Date of Patent: February 8, 2022Assignee: Sanofi-Aventis Deutschland GMBHInventors: Christian Rehbein, Samuel Steel, Anthony Paul Morris, Matthew Meredith Jones, Robert Veasey, Richard James Vincent Avery, William Marsh
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Patent number: 11224366Abstract: The various embodiments disclosed herein are devices that deliver electrical stimulation and/or vibration stimulation to the surface of skin in proximity to insulin injections and/or glucose testing in order to decrease or eliminate the pain of these procedures.Type: GrantFiled: December 10, 2018Date of Patent: January 18, 2022Assignee: Innova Medical Design LLCInventors: Timothy O'Malley, Rommel Vallero
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Patent number: 11183287Abstract: A method, system and computer-readable medium are provided for determining compliance with patient care protocols, comprising an infusion pump providing infusion information pertaining to one or more drugs administered to a patient, the one or more drugs including sedatives and analgesics, and a processor communicably coupled to the infusion pump and configured to determine information regarding the one or more drugs being administered to the patient based on the infusion information by determining a baseline threshold for the one or more drugs being administered to the patient according to the actual dosage of the one or more drugs administered to the patient prior to a current time, determining a dosage amount of the one or more drugs currently being administered to the patient and comparing the dosage amount of the one or more drugs currently being administered to the baseline threshold to determine a deviation from the baseline threshold.Type: GrantFiled: December 6, 2013Date of Patent: November 23, 2021Assignee: CareFusion 303, Inc.Inventors: Tom Steinhauer, Terry Lee Blansfield, Leonard Mulkowsky, Andres Jesus Calderon, III
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Patent number: 11160919Abstract: Mixing/administration systems and methods for preparing an agent for administration to an individual are disclosed. Caps may be included as part of the system, which may include compositions comprising at least one of a cleansing, antiseptic, antimicrobial, or disinfectant agent. The caps may additionally be included that may be used for hemostasis at an injection site. Packaging and/or the mixing/administration system within it may include a tracking mechanism for data tracking regarding many different aspects of the system, including aspects of manufacture and administration.Type: GrantFiled: July 9, 2019Date of Patent: November 2, 2021Assignee: Hyprotek, Inc.Inventor: Patrick O. Tennican
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Patent number: 11164672Abstract: A system for electronic patient care includes a network, a facility gateway, a device gateway application and a medical device. The facility gateway is configured to provide a publish-subscribe service for an application. The device gateway application is configured for execution by the facility gateway. The device gateway is configured to communicate via the network by providing a web service. The medical device is in operative communication with the network. The medical device is configured to communicate with the device gateway using the web service.Type: GrantFiled: February 11, 2019Date of Patent: November 2, 2021Assignee: DEKA Products Limited PartnershipInventors: Dean Kamen, John J. Biasi
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Patent number: 11156972Abstract: A system for light commercial building solutions (LCBS). Solutions and other systems may incorporate lightweight alerting service, auto-adjustment of gateway poll rates based on the needs of various consuming applications, detecting loss of space comfort control in a heating, ventilation and air conditioning (HVAC) system, HVAC capacity loss alerting using relative degree days and accumulated stage run time with operational equivalency checks, and HVAC alerting for loss of heat or cool capacity using delta temperature and dependent system properties. Also, incorporated may be triggering s subset of analytics by automatically inferring HVAC equipment details from controller configuration details, ensuring reliability of analytics by retaining logical continuity of HVAC equipment operational data even when controllers and other parts of the system are replaced, and an LCBS gateway with workflow and mechanisms to associate to a contractor account.Type: GrantFiled: January 10, 2020Date of Patent: October 26, 2021Assignee: Honeywell International Inc.Inventors: Paul Wacker, Gutha Stalin Sanghamitra, Suresh Vemuri
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Patent number: 11151517Abstract: A method, system, and computer product for prompting a patient to take a medicine including collecting medicine prescription information associated with a patient, collecting medicine usage data associated with the patient, comparing the medicine usage data with the medicine prescription information, determining whether a medicine is taken by the patient as prescribed in the prescription information based on a comparison result of the medicine usage data and the prescription information, and generating one or more control signals to interrupt operations of one or more devices within an environment of the patient or environments of the patient's family member or caregivers, in response to determining that the medicine is not taken as prescribed.Type: GrantFiled: April 25, 2017Date of Patent: October 19, 2021Assignee: International Business Machines CorporationInventors: Bradley C. Herrin, Morris S. Johnson, Jr., Jarett Stein, Xianjun Zhu
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Patent number: 11116308Abstract: In some embodiments, an authorization server device receives a request for an activation token to activate a personal care device. The authorization server device determines an authorized usage amount, and generates an activation token based on the authorized usage amount to be transmitted to the personal care device. Activation of a personal care device may be authorized based on consumable products obtained for use with the personal care device. By limiting activation of the personal care device based on consumable products obtained for use with the personal care device, the technical problems in overuse of some consumable products (such as brush heads) or underuse of other consumable products (such as serums or cleansers) can be avoided, and maximum results from use of the personal care devices can be easier to obtain.Type: GrantFiled: April 12, 2019Date of Patent: September 14, 2021Assignee: L'OrealInventors: Zane Bowman Allen Miller, Geoffrey Deane
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Patent number: 11107556Abstract: Systems and methods are provided for controlling dissemination of genomic data. One embodiment is a system that stores genomic data. The genomic data for each individual lists genetic variants determined to exist within that individual. The system receives an access request for a segment of genomic data for an individual, analyzes an authentication token within the request, authenticates the request as belonging to an account for a user based on the authentication token, and reviews authorization directives for the individual that indicate how predefined portions of genomic data are shared. The system also transmits the segment of genomic data in response to determining that the authorization directives permit the account to access the segment of genomic data, and prevents transmission of the segment of genomic data in response to determining that the authorization directives do not permit the account to access the segment of genomic data.Type: GrantFiled: August 29, 2017Date of Patent: August 31, 2021Assignee: Helix OpCo, LLCInventors: Rani K. Powers, Christopher M. Glode, Ryan P. Trunck, Jennifer L. Lescallett
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Patent number: 11083843Abstract: Methods, system and devices for monitoring a plurality of parameters associated with a closed loop control operation including continuously monitoring a physiological condition and automatic administration of a medication, detecting an adverse condition associated with the monitored physiological condition or the medication administration deviating from a predetermined safety level of the closed loop control operation, and initiating a non-zero pre-programmed medication delivery rate are provided.Type: GrantFiled: August 14, 2018Date of Patent: August 10, 2021Assignee: Abbott Diabetes Care Inc.Inventors: Gary Alan Hayter, Marc Barry Taub, Daniel Milfred Bernstein, Mark Kent Sloan
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Patent number: 11085588Abstract: The invention relates to the balancing of fluid streams in a dialysis system. In particular the invention relates to a cassette for conveying a first and a second fluid stream in a dialysis system, wherein the first and the second fluid streams can be medical fluid streams such as for example dialysate streams or blood streams, wherein the cassette has a sensor as a device for balancing the first and the second fluid stream, and wherein the sensor has a first channel for the first fluid stream and a second channel for the second fluid stream. The invention further relates to a dialysis system, which is configured to accommodate at least one cassette which is configured as described above. Furthermore, the present invention relates to an arrangement by which two channels for the first and the second fluid streams are formed. In addition, the invention relates to a method for construction of the two channels or the arrangement.Type: GrantFiled: June 25, 2018Date of Patent: August 10, 2021Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBHInventors: Dejan Nikolic, Alexander Heide
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Patent number: 11077091Abstract: The present invention relates to stable therapeutic compositions of pharmaceutical grade acids and pH buffering agents. The present invention also is directed to methods of treatment for mitochondrial disorders, metabolic conditions, diabetic conditions, and cardiovascular conditions, by administration of compositions of the present disclosure.Type: GrantFiled: October 28, 2019Date of Patent: August 3, 2021Assignee: Reven IP HoldCo LLCInventors: James Ervin, Hendrik J. Van Wyk, Brian D. Denomme, Mariette L. Van Wyk, Peter Pacult, Michael A. Volk
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Patent number: 11064946Abstract: Skin-mounted or epidermal devices and methods for monitoring biofluids are disclosed. The devices comprise a functional substrate that is mechanically and/or thermally matched to skin to provide durable adhesion for long-term wear. The functional substrates allow for the microfluidic transport of biofluids from the skin to one or more sensors that measure and/or detect biological parameters, such as rate of biofluid production, biofluid volume, and biomarker concentration. Sensors within the devices may be mechanical, electrical or chemical, with colorimetric indicators being observable by the naked eye or with a portable electronic device (e.g., a smartphone). By monitoring changes in an individual's health state over time, the disclosed devices may provide early indications of abnormal conditions.Type: GrantFiled: August 11, 2015Date of Patent: July 20, 2021Assignee: The Board of Trustees of the University of IllinoisInventors: John A. Rogers, Ahyeon Koh, Daeshik Kang, YuHao Liu, Xian Huang
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Patent number: 11033682Abstract: A method of insulin delivery, the method may include obtaining one or more blood glucose readings of a user, and, based on the blood glucose readings, generating a set of insulin delivery actions that may include delivery of a baseline basal rate or predefined variations of the baseline basal rate. The method may also include monitoring previous insulin delivery actions to the user to determine whether the previous insulin delivery actions include insulin beyond a threshold amount, where the previous insulin delivery actions may include delivery of the baseline basal rate or predefined variations of the baseline basal rate, and, based on the previous insulin delivery actions including insulin beyond the threshold amount, adjusting the set of insulin delivery actions.Type: GrantFiled: January 12, 2018Date of Patent: June 15, 2021Assignee: Bigfoot Biomedical, Inc.Inventors: Bryan Mazlish, Lane Desborough
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Patent number: 11033671Abstract: A system for detecting whether a vascular access has been interrupted in an arrangement in which two catheters or needles are present in a blood vessel, fistula or graft. A fluid line leading to a pump is connected via a first connector to a first indwelling catheter, and a fluid line leading from a pump is connected via a second connector to a second indwelling catheter. Each connector is equipped with an electrode in contact with the lumen of the connector, the electrodes electrically connected to an electronic circuit that measures the impedance or conductivity of fluid between the first connector and second connectors via a fluid path through the blood vessel, fistula or graft. An electronic controller receives the impedance or conductivity data and processes the data to determine whether a vascular access disconnection has occurred.Type: GrantFiled: June 18, 2018Date of Patent: June 15, 2021Assignee: DEKA Products Limited PartnershipInventors: Dirk A. van der Merwe, Michael G. Norris, Michael A. Baker, Todd A. Ballantyne, Michael J. Wilt
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Patent number: 10966609Abstract: An integrated system for the monitoring and treating diabetes is provided, including an integrated receiver/hand-held medicament injection pen, including electronics, for use with a continuous glucose sensor. In some embodiments, the receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated system electronics) and to automatically set a bolus dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus dose of medicament into the host. In some embodiments, the integrated receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging electrical contacts and/or via wireless communication.Type: GrantFiled: March 19, 2019Date of Patent: April 6, 2021Assignee: DexCom, Inc.Inventors: Mark C. Brister, Nelson Quintana, Antonio C. Llevares, John Michael Dobbles, Richard C. Yang, Michael Robert Mensinger
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Patent number: 10922961Abstract: A remote control device may be used to wirelessly control functions of one or more dialysis machines, e.g. in a clinic environment and without requiring direct contact with the dialysis machines. Components of the remote control device may include control interfaces, e.g. buttons, for controlling and adjusting functions of a medical device, such as a dialysis machine, including, for example, volume control, blood pump control blood flow rate control and/or adjusting the level in the venous drip chamber, among other control features. Display of the remote control device may include one or more screens that may display information of one or more dialysis machines, patients undergoing dialysis treatment, and/or alarms or alerts of one or more of the dialysis machines. In an implementation, ultrasonic communication is used to wirelessly exchange information and commands between the remote control device and the one or more dialysis machines.Type: GrantFiled: March 13, 2019Date of Patent: February 16, 2021Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Sameera Anirudh Peesapati, David Yuds
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Patent number: 10912524Abstract: A modular patient monitor has a docking station configured to accept a handheld monitor. The docking station has standalone patient monitoring functionality with respect to a first set of parameters. At least some of the first parameter set are displayed simultaneously on a full-sized screen integrated with the docking station. The handheld monitor also has standalone patient monitoring functionality with respect to a second set of parameters. At least some of the second set of parameters are displayed simultaneously on a handheld-sized screen integrated with the handheld monitor. The docking station has a port configured to accept the handheld monitor. While the handheld monitor is docket in the port, the docking station functionally combines the first set of parameters and the second set of parameters, and at least some of the combined first and second sets of parameters are displayed simultaneously on the full-sized screen.Type: GrantFiled: August 20, 2014Date of Patent: February 9, 2021Assignee: Masimo CorporationInventors: Ammar Al-Ali, Paul Jansen, Massi Joe E. Kiani, Anand Sampath
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Patent number: 10916896Abstract: A connector apparatus with a power isolation capability that is designed to transmit electricity from a power source to an electrical device is provided. The connector apparatus includes a housing with an input connector designed to electrically couple to the power source and an output connector designed to electrically couple to the electrical device, and a power isolation chip disposed in the housing and having an input electrically coupled to the input connector of the housing and an output electrically coupled to the output connector of the housing. The power isolation chip is designed to isolate its negative and positive output terminals from its negative and positive input terminals, thereby minimizing the generation of interference in the connector apparatus that transfers to the electrical device.Type: GrantFiled: March 12, 2020Date of Patent: February 9, 2021Inventor: Frank Dale Boxberger
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Patent number: 10894125Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver fluid to a body of a user involves obtaining measurement values for a physiological condition influenced by the fluid, autonomously operating the infusion device to deliver the fluid based at least in part on the measurement values, and detecting a nonactionable condition based on the measurement values. In response to detecting the nonactionable condition, delivery of the fluid is limited while maintaining autonomous operation of the infusion device. In one exemplary embodiment, the nonactionable condition is a rescue condition indicative of the user having consumed fast-acting carbohydrates, and thus insulin delivery may be automatically limited in response to detecting the rescue carbohydrate consumption.Type: GrantFiled: October 16, 2018Date of Patent: January 19, 2021Assignee: MEDTRONIC MINIMED, INC.Inventors: Neha J. Parikh, Anirban Roy, Benyamin Grosman, Rebecca K. Gottlieb, Di Wu
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Patent number: 10888702Abstract: An interrogation system for a medical device includes a memory storing a diagnostic algorithm, a processor configured to run the diagnostic algorithm, and a communication module configured to facilitate data transfer between the interrogation system and the medical device. The diagnostic algorithm is configured to reach a diagnostic conclusion based on data from the medical device. The diagnostic algorithm is configured to iteratively interrogate the medical device for the data from the medical device until the diagnostic algorithm reaches the diagnostic conclusion, each iterative interrogation requesting additional data as compared to prior iterations. The communication module is configured to receive the additional data from the medical device in response to each iterative interrogation. The diagnostic algorithm is further configured to store an indication of the diagnostic conclusion within the memory.Type: GrantFiled: January 6, 2017Date of Patent: January 12, 2021Assignee: Cardiac Pacemakers, Inc.Inventors: Jeffrey E. Stahmann, Howard D. Simms, Jr.
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Patent number: 10881792Abstract: The embodiments described herein may relate to methods and systems for adjusting insulin delivery. Some methods and systems may be configured to adjust insulin delivery to personalize automated insulin delivery for a person with diabetes. Such personalization may include adjusting user specific dosage parameters in response to a user provided insulin delivery amount, including a user provided insulin delivery amount that varies from a recommended insulin delivery amount. Methods and systems may include locking out automated modification of a baseline basal rate of insulin for the user for the time period after a user provides an insulin delivery amount.Type: GrantFiled: January 12, 2018Date of Patent: January 5, 2021Assignee: Bigfoot Biomedical, Inc.Inventors: Bryan Mazlish, Lane Desborough, Ross Naylor
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Patent number: 10874776Abstract: Various exemplary methods, systems, and devices for joint to pump elevation level user interfaces, autocalibration for joint elevation, and joint pressure estimation are provided. In general, an arthroscopic pump can be configured to estimate fluid pressure at a surgical site, e.g., at a joint, to provide an accurate indication of fluid pressure to users. In an exemplary embodiment, the fluid pressure estimation is based on a fluid pressure measurement at the pump that is adjusted at the pump, e.g., by a processor at the pump that executes instructions stored in a memory at the pump, using one or more control algorithms that adjust for one or more factors, such as pressure loss in tubing and sheath through which fluid flows between the pump and the surgical site and elevation difference between the pump and the surgical site.Type: GrantFiled: August 28, 2018Date of Patent: December 29, 2020Assignee: MEDOS INTERNATIONAL SARLInventors: Oliver Dumas, Eduard Grinberg, Andre Francisco Guilherme, Michael Confoey, Jacob A. Marks
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Patent number: 10864322Abstract: A portable infusion pump can communicate with glucose monitor, such as a continuous glucose monitor (CGM), to receive continuous feedback relating to a user's blood glucose level during insulin or other medicament therapy and can automatically deliver insulin to a user when the CGM data indicates a need for additional insulin. Due to potential unreliability in the correlation of the CGM data to the user's actual blood glucose level, risk mitigation can be employed to limit the amount of extra insulin that can be delivered by the pump in response to the CGM data.Type: GrantFiled: December 20, 2017Date of Patent: December 15, 2020Assignee: Tandem Diabetes Care, Inc.Inventors: Sean Saint, Michael Rosinko
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Patent number: 10864327Abstract: Methods, systems, and devices are disclosed for tracking delivery of medication. In one aspect, a medication delivery tracking device can interface with and be physically placed on a medication delivery pen device. The medication delivery tracking device can detect an occurrence of a delivery of a medication by the medication delivery pen device. In some implementations, the medication delivery tracking device can detect a dose amount of the medication delivered by the medication delivery pen device.Type: GrantFiled: January 27, 2017Date of Patent: December 15, 2020Assignee: Companion Medical, Inc.Inventors: Sean Saint, Jack Pryor, Arnold Holmquist