Absorbable In Body Patents (Class 606/230)
  • Patent number: 10085736
    Abstract: Attachment of sutures to bone is achieved by forming a recess in the bone having a cylindrical channel surrounding a bone core and then inserting a hollow anchor body into the recess and over the bone core. Suture material is attached using openings in the anchor body and the suture material may be pinched between the inside and outside surfaces of the anchor body and the bone material.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: October 2, 2018
    Inventor: L. Pearce McCarty, III
  • Patent number: 9943393
    Abstract: Biocompatible coatings and spin finishes that can be applied to polyhydroxyalkanoate (PHA) polymers, and medical devices made from PHA polymers, have been developed. The coatings impart good lubricity to PHA polymers, particularly to fibers and braids made from these materials, making the coatings ideal for use on medical devices such as PHA braided sutures. The spin finishes can be applied to PHA fibers to facilitate their manufacture, and also for their conversion to other products, including medical textiles. The spin finishes serve to protect multifilament fiber bundles, and keep them intact following extrusion, and also to impart lubricity to the fiber bundles and monofilament fibers so that they are not damaged in subsequent processing steps particularly in textile processing. The coating reduces tissue drag of, for example, braided sutures.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: April 17, 2018
    Assignee: Tepha, Inc.
    Inventors: David P. Martin, Said Rizk, Jon I. Montcrieff, Dennis W. Connelly
  • Patent number: 9820847
    Abstract: Synthetic structures for fibrous soft tissue repair include a polymeric fibrillar structure that exhibits mechanical properties of the human fibrous soft tissue.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: November 21, 2017
    Assignee: Synthasome Inc.
    Inventors: Anthony Ratcliffe, Andreas Kern
  • Patent number: 9636109
    Abstract: The present disclosure generally relates to biodegradable and bioresorbable materials having a mineral layer on the surface of the material. More particularly, the disclosure relates to biodegradable and bioresorbable orthopedic devices having a degradable mineral layer on the surface thereof that can be used as a delivery vehicle for biological substances. Also provided are various methods of using the mineralized devices in tissue regeneration, including bone tissue engineering, and methods for producing the mineralized devices.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: May 2, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: William L. Murphy, Jae Sung Lee, Mark D. Markel, Ben K. Graf, Geoffrey Baer, Yan Lu
  • Patent number: 9533068
    Abstract: Ophthalmic suture materials made from biocompatible and biodegradable polymers with high tensile strength for use in drug delivery, methods of making them, and method of using them for ocular surgery and repair have been developed. The suture materials are made from a combination of a biodegradable, biocompatible polymer and a hydrophilic biocompatible polymer. In a preferred embodiment the suture materials are made from a poly(hydroxyl acid) such as poly(l-lactic acid) and a polyalkylene oxide such as poly(ethylene glycol) or a polyalkylene oxide block copolymer. The sutures entrap (e.g., encapsulate) one or more therapeutic, prophylactic or diagnostic agents and provide prolonged release over a period of at least a week, preferably a month.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: January 3, 2017
    Assignee: The Johns Hopkins University
    Inventors: Fabiana Kimie Kashiwabuchi, Justin Hanes, Hai-Quan Mao, Peter John McDonnell, Qingguo Xu, Shuming Zhang
  • Patent number: 9486468
    Abstract: Methods of treating an arthritic joint of a subject, including administering a pharmaceutical composition by injection into the arthritic joint, wherein the composition includes an anthocyanin or anthocyanidin, glucose, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: November 8, 2016
    Inventor: Lanny Leo Johnson
  • Patent number: 9352071
    Abstract: An implantable structure, method for making the structure and method for using the structure, where the structure includes a combination of non-absorbable and absorbable components, and the implantable structure has a randomly uniform array of materials. The resulting implantable structure provides improved tissue ingrowth and flexibility after implantation and after absorption of the absorbable materials.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 31, 2016
    Assignee: Ethicon, Inc.
    Inventors: Susanne Landgrebe, Daniel Smith, Oliver Dick
  • Patent number: 9295466
    Abstract: A surgical stapling apparatus includes a housing and an end effector secured to the housing. The housing supports a knife assembly including a knife. The end effector has first and second jaw members. One or both of the first and second jaw members define a knife channel. The first jaw member defines fastener slots and the second jaw member defines fastener pockets. One or more of the knife channel, the fastener slots, and the fastener pockets includes lateral recesses. Fasteners are disposed in the fastener slots and formed by the fastener pockets. One or more surgical buttresses have a body that overlies one or both of the fastener slots and the fastener pockets. Portions of the body of the one or more surgical buttresses are disposed within the lateral recesses to secure the one or more surgical buttresses to one or both of the first jaw member and the second jaw member.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: March 29, 2016
    Assignee: Covidien LP
    Inventors: Gerald N. Hodgkinson, Scott J. Prior
  • Patent number: 9211205
    Abstract: A biodegradable, bioabsorbable medical device with a coating for capturing progenitor endothelial cells in vivo and delivering a therapeutic agent at the site of implantation. The coating on the medical device is provided with a bioabsorbable polymer composition such as a bioabsorbable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive for controlling the rate of delivery of the therapeutic agent.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: December 15, 2015
    Assignee: ORBUSNEICH MEDICAL, INC.
    Inventor: Robert J. Cottone
  • Patent number: 9173979
    Abstract: Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: November 3, 2015
    Assignee: Ethicon, Inc.
    Inventors: Brian M. Kelly, Dennis D. Jamiolkowski, Christopher DeFelice
  • Publication number: 20150133868
    Abstract: A novel high tensile strength semi-absorbable composite suture with minimized non-absorbable mass. The suture has a core made from a bioabsorbable polymer. The core is covered by a braided sheath. The braided sheath is made from an absorbable yarn and a bioabsorbable yarn. The bioabsorbable yarn is made from a least one filament of a bioabsorbable polymer. The nonabsorbable yarn is made from at least one filament of ultra high molecular weight polyethylene.
    Type: Application
    Filed: January 22, 2015
    Publication date: May 14, 2015
    Inventors: IIya Koyfman, Terry E. Lawler, Robert C. Di Luccio, Dennis D. Jamiolkowski
  • Publication number: 20150119935
    Abstract: Novel absorbable monofilament sutures and fibers having unique and improved properties are disclosed including mid-term strength retention post-implantation. Also disclosed is a novel method of manufacturing absorbable monofilament sutures and fibers. The sutures and fibers are extruded from poly(p-dioxanone-co-glycolide) copolymers.
    Type: Application
    Filed: October 31, 2013
    Publication date: April 30, 2015
    Applicant: Ethicon, Inc.
    Inventors: Sasa Andjelic, Kenneth Keilman, Dennis D. Jamiolkowski
  • Publication number: 20150100086
    Abstract: A composition includes polydioxanone and/or a copolymer thereof and at least one carboxylic salt. A molding includes the composition. A thread includes the composition. A medical kit includes the composition and a medical product includes the composition.
    Type: Application
    Filed: March 28, 2013
    Publication date: April 9, 2015
    Applicant: ITV Denkendorf Produktservice GmbH
    Inventors: Sven Oberhoffner, Erhard Müller
  • Publication number: 20150100084
    Abstract: The present disclosure generally relates to medical devices including sutures and methods of use thereof. The medical device may include a suture having projections angled with respect to a longitudinal axis of the suture and a needle coupled to the suture for inserting the suture into tissue, wherein the projections may allow movement of the suture in a first direction and prevent movement in a second direction. The suture may include an anchor at a distal end such that once the needle is removed, the suture may be pulled in a proximal direction to engage the anchor with an inner tissue wall to tighten and secure the suture within the tissue.
    Type: Application
    Filed: October 6, 2014
    Publication date: April 9, 2015
    Inventors: Claude O. CLERC, Laurie A. SODERBOM
  • Publication number: 20150088166
    Abstract: Methods and apparatuses for lifting, suspending and stiffening a patient's tissue are disclosed. In an embodiment, a method of lifting and stiffening a patient's tissue includes inserting at least one suture into the patient's tissue in a first direction, pulling the suture in a second direction so as to lift and suspend the tissue in a lifted position and stiffen the tissue in the lifted position, and cutting the suture so that the tissue remains in the lifted position. Preferably, the patient's tissue is the patient's soft palate.
    Type: Application
    Filed: September 23, 2014
    Publication date: March 26, 2015
    Inventors: Yosef P. KRESPI, David VOLPI
  • Patent number: 8940017
    Abstract: A hernia repair implant includes a first layer for facing a body structure having a hernia defect to cover the defect while promoting tissue growth into the first layer from the body structure. The implant also includes a second layer opposed to the first layer and made of anti-adhesion material to prevent growth of tissue into the second layer from body structures contacting the second layer. Furthermore, the implant includes at least one engagement strap connected to the first layer and extending therefrom to terminate at a free end. The engagement strap defines opposed thin edges and opposed flat surfaces extending between the edges. At least one barb extends from at least one edge and/or at least one flat surface of the strap and is configured to impede motion of the strap in only a single direction.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: January 27, 2015
    Assignee: Insightra Medical, Inc.
    Inventors: Stephen Graham Bell, Wayne A. Noda, Giuseppe Amato
  • Publication number: 20150018876
    Abstract: Tissue anchors include a flat, broad, and large contact surface for engagement with a portion of tissue. Several embodiments of composite tissue anchors include a support element and an overlay element. Tissue anchor assemblies include two or more tissue anchors, a connector, and a cinching mechanism. In some embodiments, the tissue anchors included in the tissue anchor assemblies are of different types, sizes, and/or shapes.
    Type: Application
    Filed: October 1, 2014
    Publication date: January 15, 2015
    Inventors: Richard C. Ewers, Tracy D. Maahs, Shirley Vong
  • Publication number: 20140371767
    Abstract: The present disclosure provides filaments and/or surgical sutures which include an inner core, an outer sheath and a plurality of barbs on a surface thereof. The filaments and/or surgical sutures further include at least one adhesive precursor material which transitions from a non-adherent material to an adhesive material to attach a portion of the filament and/or suture to the surrounding area, such as tissue and/or other portions of the filament.
    Type: Application
    Filed: May 5, 2014
    Publication date: December 18, 2014
    Applicant: Covidien LP
    Inventors: Roland Ostapoff, Timothy Sargeant
  • Patent number: 8858595
    Abstract: Bioswellable sutures are provided in the form of absorbable, compliant monofilaments of an amphiphilic copolyester, an absorbable multifilament braid, a non-absorbable monofilament with swellable outer layer, a non-absorbable multifilament braid with an absorbable monofilament core of an amphiphilic copolymer, and a non-absorbable, multifilament braid molecularly integrated with an outer sheath that is highly hydrophilic.
    Type: Grant
    Filed: June 14, 2006
    Date of Patent: October 14, 2014
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, James M. Lindsey, III
  • Publication number: 20140288592
    Abstract: A variety of medical devices including staples sutures and dental floss with surface treatment on at least one tissue-facing surface to improve biologic function such as to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm2, and ii) a thrombin deactivation of at least 0.2 IU/cm2; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Applicant: ENSION, INC.
    Inventors: Ali HUSSAIN, Linda Cahalan, Greg Johnson, Mark Gartner, Patrick Cahalan, Brian J. Fill, Jeffrey W. Speakman
  • Patent number: 8834522
    Abstract: Described herein are a group of degradable, thermoplastic polymers, which are able to change their shape after an increase temperature. Their shape memory capability enables bulky implants to be placed in the body through small incisions or to perform complex mechanical deformations automatically. The shape memory polymers are preferably biocompatible and can be biodegradable or non-degradable polymers. Preferably, the biodegradable polymer has a linear degradation rate. In a specifically preferred embodiment, the suture is formed of biodegradable polymer capable of forming a self-tightening knot. In a most preferred embodiment, the suture is used to close a wound or body scission.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: September 16, 2014
    Assignee: Helmholtz-Zentrum Geestahacht Zentrum fur Material und Kustenforschung
    Inventors: Andreas Lendlein, Robert S Langer
  • Patent number: 8821545
    Abstract: A surgical filament snare assembly including an anchor capable of being fixated in bone and having a filament engagement feature. A first filament has a noose with first and second noose limbs connected, preferably slidably, to the filament engagement feature. The first and second noose limbs emerge from the anchor as first and second free filament limbs that are capable of being passed through tissue to be repaired and then passable through the noose. The noose is capable of receiving the free filament limbs and strangulating them when tension is applied to at least one of the free filament limbs and the noose to enable incremental tensioning of the tissue after anchor fixation. Preferably, the snare assembly further includes a flexible sleeve joining at least some portion of the first and second free filament limbs to facilitate passing of the free filament limbs as a single unit.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: September 2, 2014
    Assignee: DePuy Mitek, LLC
    Inventor: Mehmet Ziya Sengun
  • Patent number: 8821543
    Abstract: An adjustable anchor system for securing tissue to bone, including an anchor having at least one passage extending from a proximal end toward a distal end. The passage defines a restriction such as a restricted opening. The anchor has at least one bone-engaging feature disposed between the proximal and distal ends. The system further includes a first material formed as a closed loop and capable of being placed through a portion of the tissue, and a second filament having a terminal end, a post limb and a sliding knot tied between the terminal end and the post limb to establish an elongated, adjustable-length loop which extends beyond the proximal end of the anchor and captures the closed loop of the first material. The knot of the second filament is restrained by the restricted opening when tension is applied as desired to the post limb to shorten the elongated loop to draw the tissue toward the anchor.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: September 2, 2014
    Assignee: DePuy Mitek, LLC
    Inventors: Joseph Hernandez, Mehmet Ziya Sengun, Gerome Miller
  • Patent number: 8821544
    Abstract: A surgical filament snare assembly including an anchor capable of being fixated in bone and having a filament engagement feature. A first filament has a noose with first and second noose limbs connected, preferably slidably, to the filament engagement feature. The first and second noose limbs emerge from the anchor as first and second free filament limbs that are capable of being passed through tissue to be repaired and then passable through the noose. The noose is capable of receiving the free filament limbs and strangulating them when tension is applied to at least one of the free filament limbs and the noose to enable incremental tensioning of the tissue after anchor fixation. Preferably, the snare assembly further includes a flexible sleeve joining at least some portion of the first and second free filament limbs to facilitate passing of the free filament limbs as a single unit.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: September 2, 2014
    Assignee: DePuy Mitek, LLC
    Inventors: Mehmet Ziya Sengun, Howard Tang, David B. Spenciner
  • Publication number: 20140243891
    Abstract: Fixation of soft tissue to bone (or of soft tissue to soft tissue) is performed using a flexible material (for example, a suture strand, a braid, a suture tape, a stuffed suture, or a combination thereof) with a portion having an expanded footprint to provide a cushion or tissue protector between the flexible strand (suture) and the tissue to be attached. The suture and cushion may be manufactured from materials that have properties to amplify the body's healing response. The cushion may have any shape and geometry that provides cushioning action between the suture and the tissue to be fixated. The cushion may be provided along the length of the flexible strand (i.e., the flexible strand may be provided with a cushion) or the flexible strand may extend from the cushion.
    Type: Application
    Filed: February 21, 2014
    Publication date: August 28, 2014
    Applicant: Arthrex, Inc.
    Inventors: Reinhold Schmieding, Dustin T. Libby, Peter J. Dreyfuss, James P. Bradley
  • Patent number: 8814905
    Abstract: A surgical filament snare assembly including an anchor capable of being fixated in bone and having a filament engagement feature. A first filament has a noose on a first portion of at least a first limb and has a second portion connected to the filament engagement feature of the anchor. Preferably, at least one free filament limb, which in some embodiments is a length of the first filament and in other embodiments is a second filament, is capable of being passed through tissue to be repaired and has at least one end passable through the noose to enable incremental tensioning of the tissue after the anchor is fixated in bone. The noose strangulates the free filament limb when tension is applied to at least one of the free filament limb and the noose.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: August 26, 2014
    Assignee: DePuy Mitek, LLC
    Inventors: Mehmet Ziya Sengun, Howard Tang, David B. Spenciner, Gregory R. Whittaker, Gerome Miller
  • Patent number: 8716410
    Abstract: The present invention relates to a biodegradable thermoplastic elastomer having the general formula A-B-A wherein each A is an amorphous polymer having a glass transition temperature (Tg)>40° C. or a semi-crystalline polymer having a glass transition temperature (Tg) and/or melting temperature (Tm)>40° C.; B is a copolymer of -caprolactone (CL) and at least one additional monomer selected from the group consisting of L-lactic acid (LLA), trimethyl carbonate (TMC), and glycolic acid (GA), or B is different to A and is lactic-co-glycolic acid (LGA); and wherein the molar ratio of CL to the at least one additional monomer in the copolymer B is in the range between about 1:0.09 to about 1:1.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: May 6, 2014
    Assignee: Nanyang Technological University
    Inventors: Subramanian Venkatraman, Marc Abadie, Leonardus Kresna Widjaja, Vitali Llpik
  • Patent number: 8703627
    Abstract: An antiadhesive material that is excellent in biocompatibility and bioabsorbability, as well as excellent strength in suturing and bonding, is provided. A reinforcing material 12 made of a biodegradable polymer is placed in a gelatin solution so that the reinforcing material 12 is impregnated with the solution, and the gelatin is caused to gelate and dried. By so doing, an antiadhesive material in which a gelatin film 11 and the reinforcing material 12 are integrated is obtained. The reinforcing material 12 preferably is arranged in a portion of the gelatin film 11 to be subjected to suturing, and preferably is arranged along a periphery of the gelatin film 11. The gelatin film 11 preferably is a cross-linked gelatin film, and the reinforcing material 12 preferably is a nonwoven fabric.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: April 22, 2014
    Assignees: Gunze Limited, JMS Co., Ltd.
    Inventors: Shojiro Matsuda, Yoshimi Tanaka, Yoshito Ikada
  • Patent number: 8691899
    Abstract: An antimicrobial composition and a medical device having that antimicrobial composition that includes a complex of an anionic polyester with a monomeric amidoamine having at least one amide group and at least one amine group, wherein the amine group is either a primary amine, or a secondary amine, or a tertiary amine, or a quaternary amine, or a combination thereof and the anionic polyester has at least one carboxylic group.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: April 8, 2014
    Assignee: Ethicon, Inc.
    Inventors: Modesto Erneta, Joerg Priewe
  • Publication number: 20140088644
    Abstract: A wound closure device including a first tissue anchor with a first suture filament fixedly coupled thereto at a proximal end and extending along a length to a free distal end, and a second tissue anchor with a second suture filament fixedly coupled thereto at a proximal end and extending along a length to a free distal end. The first suture filament is configured to form a slip knot at its proximal end substantially adjacent the first tissue anchor, and the second suture is configured to form a slip knot at its proximal end substantially adjacent the second tissue anchor. The length of the first suture filament passes through the slip knot of the second suture and the length of the second suture filament passes through the slip knot of the first suture filament.
    Type: Application
    Filed: September 27, 2012
    Publication date: March 27, 2014
    Applicant: ETHICON, INC.
    Inventor: James A. Flint
  • Publication number: 20140052175
    Abstract: A novel high tensile strength semi-absorbable composite suture with minimized non-absorbable mass. The suture has a core made from a bioabsorbable polymer. The core is covered by a braided sheath. The braided sheath is made from an absorbable yarn and a bioabsorbable yarn. The bioabsorbable yarn is made from a least one filament of a bioabsorbable polymer. The nonabsorbable yarn is made from at least one filament of ultra high molecular weight polyethylene.
    Type: Application
    Filed: October 24, 2013
    Publication date: February 20, 2014
    Applicant: DePuy Mitek, LLC
    Inventors: Ilya Koyfman, Terry E. Lawler, Robert C. Di Luccio, Dennis D. Jamiolkowski
  • Patent number: 8642068
    Abstract: A biodegradable, bioabsorbable medical device with a coating for capturing progenitor endothelial cells in vivo and delivering a therapeutic agent at the site of implantation. The coating on the medical device is provided with a biabsorbable polymer composition such as a bioabsorbable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive for controlling the rate of delivery of the therapeutic agent.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: February 4, 2014
    Assignee: Orbusneich Medical, Inc.
    Inventor: Robert J. Cottone
  • Patent number: 8636767
    Abstract: The invention relates to increasing the strength of bio-absorbable surgical sutures. The invention allows for delayed bioabsorption of suture materials to allow maintenance of mechanical strength of the suture for example in ‘barbed’ form.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: January 28, 2014
    Assignee: Micell Technologies, Inc.
    Inventor: Jim McClain
  • Publication number: 20130317545
    Abstract: A drug-eluting self-retaining suture comprises a filament, a plurality of retainers, and a drug impregnated in or coated on the filament. The shape and distribution of retainers modifies the in vivo release kinetics of the drug. The drug release kinetics may be modified uniformly or region by region. The self-retaining suture may for example be used for reattaching severed nerves and release nerve growth factor or other regeneration accelerating agents into the region of the nerve injury.
    Type: Application
    Filed: November 3, 2011
    Publication date: November 28, 2013
    Inventors: Jeffrey M. Gross, Lev Drubetsky, Alexander Naimagon, Rui Avelar, William L. D'Agostino, Kevin Don Nelson, Brent B. Crow, Nickolas B. Griffin
  • Publication number: 20130315963
    Abstract: Novel absorbable polymer blends are disclosed. The blends are useful for manufacturing medical devices having engineered degradation and breaking strength retention in vivo. The blends consist of a first absorbable polymeric component and a second absorbable polymeric component. The weight average molecular weight of the first polymeric component is higher than the weight average molecular weight of the second polymeric component. At least at least one of said components is at least partially end-capped by a carboxylic acid group. Further aspects are medical devices made therefrom.
    Type: Application
    Filed: March 15, 2013
    Publication date: November 28, 2013
    Applicant: Ethicon, Inc.
    Inventors: Modesto Erneta, Daniel Steiger, Dennis D. Jamiolkowski
  • Patent number: 8586125
    Abstract: A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: November 19, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Yiwen Tang, Manish B. Gada
  • Patent number: 8579939
    Abstract: Silk/absorbable polyester hybrid medical devices for tissue repair and regeneration are formed of degummed, naturally produced, multifilament silk yarn in combination with at least one absorbable polyester in the form of a surface coating, with or without an antimicrobial agent, for producing value-added braided silk sutures and multifilament yarn, as well as silk/absorbable polyester fiber composites, for producing tailored hybrid sutures, meshes, and scaffolds for tissue regeneration.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: November 12, 2013
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W Shalaby
  • Publication number: 20130296932
    Abstract: The present disclosure relates to coated biodegradable materials having a reduced amount of residual catalysts and methods thereof.
    Type: Application
    Filed: July 3, 2013
    Publication date: November 7, 2013
    Inventors: Nadya D. Belcheva, Norman Aminuddin
  • Publication number: 20130296893
    Abstract: The suture device of the present disclosure disposes rigid components on suture, enabling the device to resist tensile and compressive loads and to protect soft tissue from suture pull-through. The suture device generally comprises of at least one rigid segment as well as a standard high tensile strength suture to create a segmentally rigid suture device. The at least one rigid segment may be comprised of any of a number of materials that are appropriate for use in the human body and provide the desired strength and stiffness for a particular application. Although the segmentally rigid suture device could be used with any prior art suture configuration, a grip stitch, a knot tying grip stitch, a straight-line grip stitch, and a reverse straight-line grip stitch suture configuration are described.
    Type: Application
    Filed: April 30, 2013
    Publication date: November 7, 2013
    Inventors: John C. Dean, Jonathan H. Webb
  • Publication number: 20130172931
    Abstract: A self-retaining suture having particular application for treating obstructive sleep apnea and use thereof. The suture includes rising an elongated suture body having a periphery and first and second tissue-penetrating ends each with a bi-curve needle, and a plurality of first retainers on a first segment and oriented to the first end, and a plurality of second retainers a second segment and oriented to the second end, and a retainer-free transition segment disposed between the pluralities of first and second retainers.
    Type: Application
    Filed: June 5, 2012
    Publication date: July 4, 2013
    Inventors: Jeffrey M. Gross, Malcolm D. Paul
  • Patent number: 8476402
    Abstract: The present invention relates to a novel carbohydrate lactone, functionalized aliphatic polyesters and copolymers formed therefrom, and processes for the preparation thereof from renewable resources.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: July 2, 2013
    Assignee: Imperial Innovations Limited
    Inventors: Charlotte K. Williams, Molly Morag Stevens, Min Tang
  • Publication number: 20130165971
    Abstract: A barbed suture for connecting tissue, and a combination surgical needle with a barbed suture. The suture includes an elongated body and a plurality of barbs projecting from the body. Each barb causes the suture to resist movement in an opposite direction from which the barb faces. The disposition of the barbs on the body may be staggered, twist cut multiple spiral, overlapping, or random. Also, the configuration of the barbs may be a certain spirality angle ?, barb cut angle ?, barb cut depth, barb cut length, barb cut distance, corrugated barb underside, arcuate barb base, or varying barb size.
    Type: Application
    Filed: December 22, 2011
    Publication date: June 27, 2013
    Inventors: Jeffrey C. Leung, Gregory L. Ruff, Matthew A. Megaro
  • Publication number: 20130110162
    Abstract: Multifilament sutures are prepared by permeating the suture with an antimicrobial solution and applying an antimicrobial coating to the suture.
    Type: Application
    Filed: August 28, 2012
    Publication date: May 2, 2013
    Inventor: Matthew Cohen
  • Publication number: 20130090521
    Abstract: A timed-release tensioned core-shell fiber comprises a core positioned within a shell. The shell is configured to hold the core under said tension or compression. The shell is at least partially removable and releases at least a portion of the tension or compression of the core in response to the shell being removed. The shell is at least partially removable by erosion or degradation due to mechanical, chemical, electrical, physical, or thermal processes, or combinations thereof. In some embodiments, the erosion or degradation of the shell may include biodegradation, bioerosion, photooxidation, or photodegradation. A fiber mesh comprised of core-shell fibers may be tuned for timed release of contraction or expansion forces in response to timed release of tension or compression of the core. The fiber mesh may be used in a medical device, bandage, implant, tissue construct, or sling. A suture may also comprise a core-shell fiber.
    Type: Application
    Filed: October 9, 2012
    Publication date: April 11, 2013
    Applicant: NOVO CONTOUR, INC.
    Inventor: Novo Contour, Inc.
  • Publication number: 20130090686
    Abstract: Barbed surgical sutures are provided which include an elongated body and a plurality of barbs extending therefrom. A bioactive agent is disposed within barb angles formed between the barbs and the elongated body. The barbs may be made from a shape memory polymer having a permanent shape which may be deformed to a temporary shape, such that barbs of the suture extend at different barb angles in the different shape configurations. The barb angles of the permanent shape may be greater than the barb angles of the temporary shape, thereby exposing and/or releasing a bioactive agent after placement in tissue.
    Type: Application
    Filed: November 30, 2012
    Publication date: April 11, 2013
    Applicant: COVIDIEN LP
    Inventor: Covidien LP
  • Publication number: 20130066423
    Abstract: Embodiments of apparatus and methods for tissue lifting, or for correcting a ptosis condition caused by tissue stretching, are described. In some embodiments a tissue is supported by a support member. In some embodiments, tension is applied to a support member through at least one suspension member. The described embodiments provide examples of methods and apparatus effective for use in lifting or otherwise applying tension to various tissues, including tissues of the breast, buttock, thigh, arm, abdomen, neck and face.
    Type: Application
    Filed: September 10, 2012
    Publication date: March 14, 2013
    Inventors: Gordon Bishop, Randy Lashinski
  • Publication number: 20130066369
    Abstract: A suture assembly and a method for making the same is provided. The suture assembly includes a plurality of unbarbed filamentary elements intertwined with one another and at least one barbed filamentary element having a longitudinal axis and having plurality of barbs extending outwardly therefrom in a first direction less than 90 degrees from the longitudinal axis. According to exemplary embodiments, the at least one barbed filamentary may be intertwined along its length with the plurality of unbarbed filamentary elements, and the plurality of barbs extending outwardly beyond the unbarbed filamentary elements, or the primary outer periphery of the at least one barbed filamentary element may be contained within the intertwined unbarbed filamentary elements with the plurality of barbs extending through and outwardly from the plurality of unbarbed filamentary elements.
    Type: Application
    Filed: September 17, 2012
    Publication date: March 14, 2013
    Applicant: Ethicon, Inc.
    Inventors: John P. Collier, David C. Lindh, SR., Jesse G. Nawrocki, Krasimira Hristov
  • Patent number: 8383188
    Abstract: A high strength surgical suture material with improved tie down characteristics and tissue compliance formed of ultrahigh molecular weight polyethylene (UHMWPE) yarns, the suture being coated with arginine-glycine-aspartate (RGD) peptide. The suture has exceptional strength, is ideally suited for most orthopedic procedures, and can be attached to a suture anchor or a curved needle.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: February 26, 2013
    Assignee: University of Connecticut
    Inventors: Augustus D. Mazzocca, Mary Beth McCarthy
  • Publication number: 20120323274
    Abstract: Described herein are a group of degradable, thermoplastic polymers, which are able to change their shape after an increase temperature. Their shape memory capability enables bulky implants to be placed in the body through small incisions or to perform complex mechanical deformations automatically. The shape memory polymers are preferably biocompatible and can be biodegradable or non-degradable polymers. Preferably, the biodegradable polymer has a linear degradation rate. In a specifically preferred embodiment, the suture is formed of biodegradable polymer capable of forming a self-tightening knot. In a most preferred embodiment, the suture is used to close a wound or body scission.
    Type: Application
    Filed: August 28, 2012
    Publication date: December 20, 2012
    Applicant: Helmholtz-Zentrum Geestahacht Zentrum fur Material und Kustenforschung
    Inventors: Andreas Lendlein, Robert S. Langer
  • Publication number: 20120323273
    Abstract: A novel high tensile strength semi-absorbable composite suture with minimized non-absorbable mass. The suture has a core made from a bioabsorbable polymer. The core is covered by a braided sheath. The braided sheath is made from an absorbable yarn and a bioabsorbable yarn. The bioabsorbable yarn is made from a least one filament of a bioabsorbable polymer. The nonabsorbable yarn is made from at least one filament of ultra high molecular weight polyethylene.
    Type: Application
    Filed: December 20, 2011
    Publication date: December 20, 2012
    Applicant: DEPUY MITEK, INC.
    Inventors: Ilya Koyfman, Terry E. Lawler, Robert C. Di Luccio, Dennis D. Jamiolkowski