Stimulating Respiration Function Patents (Class 607/42)
  • Patent number: 11363984
    Abstract: An automated method and system for diagnosing sleep disorders and predicting treatment effectiveness using data collected on the user using an automated application including questionnaire, facial recognition technology, and historical user and patient data. The data can be used by a diagnostic and treatment prediction algorithm to diagnose sleep disorders, for example sleep apnea, and predict treatment effectiveness. The system is an automated, self-learning algorithm capable of assessing the risk for sleep disorders and predicting treatment effectiveness.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: June 21, 2022
    Assignee: SNOOZE, INC.
    Inventor: Jordan C. Stern
  • Patent number: 11357979
    Abstract: A system for stimulating body tissue may include a stimulation lead, sensors, and a control unit. The stimulation lead may include one or more energy sources. The control unit may include a processor and non-transitory computer readable medium, and an interface (e.g., touch screen interface) for receiving user inputs and communicating information to the user. The sensors may be configured to provide impedance measurements to the control unit. The control unit may calculate lung gas distributions and/or generate an image modeling lung gas distributions. Stimulation delivered by the stimulation may be adjusted based on the impedance measurements.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: June 14, 2022
    Assignee: Lungpacer Medical Inc.
    Inventors: Douglas G. Evans, Viral S. Thakkar
  • Patent number: 11324954
    Abstract: A system for stimulating phrenic nerves to provide smooth breathing patterns is provided. More specifically, by identifying contraction threshold voltages for muscles associated with each of the left and right portions of a patient's diaphragm, a phrenic nerve pacing signal customized for each phrenic nerve may be provided to a patient. More specifically, a voltage of a pacing voltage provided to a first phrenic nerve may be less than the contraction threshold while a voltage of a pacing voltage provided to a second phrenic nerve may be greater than the contraction threshold.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: May 10, 2022
    Assignee: Covidien LP
    Inventors: Abhijit Bhattacharya, Berthold Stegemann
  • Patent number: 11324658
    Abstract: A device is provided for controlling the nitric oxide levels within the lungs of a subject. The device comprises a detector for detecting the respiration cycle of the subject and a stimulator for applying an acoustic or vibratory stimulus to the subject. The stimulator is controlled in dependence on the detected respiration cycle. In particular, acoustic stimulation may be provided at the onset of inspiration. In this way, the nitric oxide flow can be controlled in a way to ensure that the paranasal nitric oxide is nearly fully inspired. This provides a higher nitric oxide concentration in the lung/alveoli.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: May 10, 2022
    Assignee: Koninklijke Philips N.V.
    Inventors: Joachim Kahlert, Maria Estrella Mena Benito
  • Patent number: 11266837
    Abstract: An implantable neurostimulator (INS) and method of use, the INS including an electrical lead having formed thereon at least a pair of bi-polar electrodes, wherein the electrical lead is configured for placement of the pair of bi-polar electrodes proximate protrusor muscles of a patient, a pulse generator electrically connected to the electrical lead and configured to deliver electrical energy to the pair of bi-polar electrodes, the pulse generator having mounted therein a sensor and a control circuit, and the sensor is configured to generate signals representative of an orientation of the pulse generator and communicate the signals to the control circuit and the control circuit is configured to determine the orientation of the pulse generator and deliver electrical energy to the bi-polar electrodes when the determined orientation correlates to a pre-determined orientation.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: March 8, 2022
    Assignee: MEDTRONIC XOMED, INC.
    Inventors: Avram Scheiner, James Hissong
  • Patent number: 11266838
    Abstract: A device and method for treating a variety of conditions, disorders or diseases with diaphragm/phrenic nerve stimulation is provided.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: March 8, 2022
    Assignee: RMX, LLC
    Inventor: Amir J. Tehrani
  • Patent number: 11259801
    Abstract: A surgical instrument including a housing, an endoscopic portion, a shaft portion and an end effector is disclosed. The endoscopic portion extends distally from the housing and defines a longitudinal axis. The shaft portion is selectively connectable to a distal end of the endoscopic portion. The end effector is selectively connectable to a distal end of the shaft portion.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: March 1, 2022
    Assignee: Covidien LP
    Inventors: Michael Zemlok, David Racenet
  • Patent number: 11246622
    Abstract: An apparatus includes a body, a shaft assembly, an end effector, and a control module. The shaft assembly extends distally from the body and includes an acoustic waveguide. The waveguide is configured to acoustically couple with an ultrasonic transducer. The end effector includes an ultrasonic blade, a clamp arm, an electrode, and a sensor. The ultrasonic blade is in acoustic communication with the waveguide. The clamp arm is operable to compress tissue against the ultrasonic blade. The electrode is operable to apply radiofrequency (RF) electrosurgical energy to tissue. The sensor is operable to sense a condition of tissue contacted by the end effector. The control module is operable to control delivery of ultrasonic power and RF electrosurgical energy through the end effector based on data from the sensor.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: February 15, 2022
    Assignee: Cilag GmbH International
    Inventor: Kevin L. Houser
  • Patent number: 11191970
    Abstract: A device for conveying power from a location external to a subject to a location within the subject may include a flexible carrier and an adhesive on a first side of the carrier. A coil of electrically conductive material may be associated with the flexible carrier. A mechanical connector may be associated with the carrier opposite the adhesive, wherein the mechanical connector is configured to retain a housing and permit the housing to rotate relative to the flexible carrier. At least one electrical portion may be associated with the carrier in a manner permitting electrical connection to be maintained between the flexible carrier and the housing as the housing is rotated.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: December 7, 2021
    Assignee: Nyxoah SA
    Inventors: Adi Mashiach, Tim Ruytjens
  • Patent number: 11123557
    Abstract: An electric stimulator that effectively improves the brain function of patients suffering from brain disorders by applying electric stimulation to the brain of the patient effectively. The electric stimulator can include main electrodes H to be stuck to particular sites of the patient's body extending from the neck part to the head tip part. The particular site may be the temple part, the forehead part above the eyes, the cheek part and the rear neck part. The electric signal to be applied to the main electrodes H is set so as for weak electric current of 100 ?A or less to flow through the patient's body and stimulate the brain. In addition to the application of electric stimulation by the main electrodes H, auxiliary electrodes S may be stuck to the back of the patient.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: September 21, 2021
    Assignees: NIHON MEDIX Co., Ltd.
    Inventors: Kensuke Yamakawa, Norikazu Yoshioka, Hitoshi Aoki
  • Patent number: 11116397
    Abstract: Aspects of the subject disclosure may include, for example, a system adapted for determining from sensor data collected for a patient over a period of time a normative condition of a biological function of the patient, generating provisioning information according to the normative condition, detecting a first sensor coupled to the patient, and providing the provisioning information to the first sensor to enable the first sensor to detect an abnormal state of the biological function of the patient. Other embodiments are disclosed.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: September 14, 2021
    Assignee: Welch Allyn, Inc.
    Inventors: David E. Quinn, Craig M. Meyerson, John A. Lane, Kenzi L. Mudge
  • Patent number: 11090489
    Abstract: A method for positioning an intravascular catheter may include inserting the intravascular catheter into a venous system of a patient, wherein the catheter includes a plurality of electrodes, and multiple electrodes of the plurality of electrodes are configured to emit electrical signals; positioning a distal portion of the catheter in a first position; using one or more electrodes of the plurality of electrodes to acquire an ECG signal; based on the acquired ECG signal, adjusting the distal portion of the catheter to a second position different from the first position; identifying at least one first electrode of the plurality of electrodes to stimulate a first nerve; identifying at least one second electrode of the plurality of electrodes to stimulate a second nerve; and stimulating at least one of the first and second nerves to cause a contraction of a respiratory muscle.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: August 17, 2021
    Assignee: Lungpacer Medical, Inc.
    Inventors: Viral S. Thakkar, Douglas G. Evans, Matthew J. Gani
  • Patent number: 11065444
    Abstract: Devices and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache and trigeminal neuralgia and the like, by noninvasive electrical stimulation of nerves of the head, particularly supraorbital, supratrochlear, infraorbital, and mental nerves in the vicinity of their foramen or notch. The system comprises a handheld mobile device, such as a smartphone, that is applied to the surface of the patient's head. One or more electrodes on the mobile device apply electrical impulses transcutaneously through the patient's skin to the targeted nerve to treat the medical condition. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: July 20, 2021
    Assignee: ElectroCore, Inc.
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Patent number: 11065443
    Abstract: A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: July 20, 2021
    Assignee: Zoll Respicardia, Inc.
    Inventors: Mark Gelfand, Kristofer J. James, Randy W. Westlund, Antonis Panteleon, Todd P. Goblish, Mark C. Lynn
  • Patent number: 11027130
    Abstract: Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.
    Type: Grant
    Filed: March 24, 2020
    Date of Patent: June 8, 2021
    Assignee: Lungpacer Medical Inc.
    Inventor: Joaquin Andres Hoffer
  • Patent number: 11020596
    Abstract: An implantable system, and methodology, for improving a heart's hemodynamic performance featuring (a) bimodal electrodes placeable on the diaphragm, out of contact with the heart, possessing one mode for sensing cardiac electrical activity, and another for applying cardiac-cycle-synchronized, asymptomatic electrical stimulation to the diaphragm to trigger biphasic, diaphragmatic motion, (b) an accelerometer adjacent the electrodes for sensing both heart sounds, and stimulation-induced diaphragmatic motion, and (c) circuit structure, connected both to the electrodes and the accelerometer, operable, in predetermined timed relationships to the presences of valid V-events noted in one of sensed electrical and sensed mechanical, cardiac activity, to deliver diaphragmatic stimulation.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: June 1, 2021
    Assignee: VisCardia, Inc.
    Inventor: Peter T. Bauer
  • Patent number: 11007001
    Abstract: Some embodiments relate to a method of reducing excess mucosa production and/or secretion in the respiratory tract, comprising: introducing into the lumen of the trachea or the lumen of the bronchi a device configured for damaging nerve tissue or blocking neural conduction in the surroundings of the lumen; and activating the device to damage the nerve tissue enough to suppress parasympathetic nerve activity which causes the excess mucosa production and/or secretion.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: May 18, 2021
    Assignee: Sonivie Ltd.
    Inventors: Charles S. Carignan, Or Shabtay, Maya Rosenstein, Dalit Shav, Talia Cohen Keizman, Daniel Naor, Ofek Admon
  • Patent number: 10994142
    Abstract: A system is disclosed in one example which allows for modelling the wellness of a given Implantable Pulse Generator (IPG) patient. The modelling, embodied in an algorithm, uses one or more qualitative measurements and one or more quantitative measurements taken from the patient. The algorithm correlates the qualitative measurements to the various quantitative measurements to eventually, over time, learn which quantitative measurements best correlate to the qualitative measurements provided by the patient. The algorithm can then using current quantitative measurements predict a wellness factor or score for the patient, which is preferably weighted to favor the quantitative measurements that best correlate to that patient's qualitative assessment of therapy effectiveness. Additionally, the wellness factor may be used to adjust the stimulation program that the IPG device provides to the patient.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: May 4, 2021
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Michael A. Moffitt
  • Patent number: 10967178
    Abstract: An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: April 6, 2021
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Boon Khai Ng, Joseph L. Calderon
  • Patent number: 10946198
    Abstract: A method, device and/or system for generating arbitrary waveforms of a desired shape that can be used for generating a stimulation pulse for medical purposes such as for spinal cord stimulation therapy, including the option of using such arbitrary waveforms for charge balancing purposes.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: March 16, 2021
    Assignee: CIRTEC MEDICAL CORP.
    Inventors: Stephen C. Trier, Jeffrey A. Weisgarber, Richard J. Polefko
  • Patent number: 10932714
    Abstract: A health status modulator analyzes frequencies emitted by a person to select and implement improvement frequencies at the person. The health status modulator detects frequency information generated at the person, for example a voice sample or a vibrational frequency, and determines which significant frequencies exist within that sample. The modulator could then seek to modify the person's state my implementing alternative frequencies that reinforce detected ideal frequencies, introduce missing ideal frequencies, or counter and eliminate negative frequencies.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: March 2, 2021
    Assignee: Soniphi LLC
    Inventors: Matthew Sanderson, Mark Hinds
  • Patent number: 10881854
    Abstract: Provided is a respiratory muscle strengthening device, in which an inhalation start signal is generated correspondingly at an inhalation start time when a patient inhales air or an exhalation start signal is generated correspondingly at an exhalation start time when the patient exhales air, an electric signal according to the inhalation start signal or the exhalation start signal is transmitted to an electric muscle stimulator via a communication unit, a muscle pad installed on respiratory muscles of the patient enables smooth breathing motion by stimulating the respiratory muscles based on a signal transmitted from the electric muscle stimulator, and a receptor pad is provided to the respiratory muscles such that an alarm of determining whether electric stimulation is normally applied via the state of the respiratory muscles detected through the receptor pad is output, thereby securing reliability of a device.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: January 5, 2021
    Assignee: RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY
    Inventors: Su Min Son, Eun Yong Choi, Joon Ha Lee, So Young Kwak
  • Patent number: 10863949
    Abstract: A method of a processor for detecting a presence of Cheyne-Stokes respiration from a respiration signal includes accessing data representative of a respiration signal. Data is assessed to detect apnea and/or hypopnea events. A cycle length histogram is determined based on the events and an incident of Cheyne-Stokes respiration is detected based on the cycle length histogram.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: December 15, 2020
    Inventors: Jeffrey Peter Armitstead, Dinesh Ramanan
  • Patent number: 10864375
    Abstract: Devices and methods for improving the coupling between the soft palate and the genioglossus. This may be accomplished, for example, but shortening or stiffening the palatoglossal arch. Improved coupling between the soft palate and the genioglossus may be beneficial to a patient suffering from obstructive sleep apnea (OSA) as a stand-alone procedure, or in combination procedures and devices that cause anterior displacement of the tongue such as hypoglossal nerve stimulation, genioglossus advancement surgery, mandibular advancement surgery, mandibular advancement (oral) appliances, etc.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: December 15, 2020
    Assignee: LivaNova USA, Inc.
    Inventors: Stephen Bolea, Wondimeneh Tesfayesus, John Beck, Thomas Hoegh, Robert Atkinson, Sidney Hauschild
  • Patent number: 10821246
    Abstract: A medical device determines operating situations and a method determines operating situations in a medical device. Based on pressure measured values (99) and flow measured values (97), it is determined whether an elevation of an airway pressure (105) in a medical device is due to a cough event (113) or to a plurality of cough events (117), which indicate an accumulation of secretion. An outputting (41, 42, 44) of a warning (44) or alarm (41, 42) is provided indicating the accumulation of secretion.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: November 3, 2020
    Assignee: Drägerwerk AG & Co. KGaA
    Inventors: Thomas Krüger, Birger Landwehr
  • Patent number: 10802780
    Abstract: A digital device according to an embodiment of the present description can receive attribute information from an external device and generate attribute information of the digital device on the basis of context information of the digital device. Moreover, the digital device can provide one or more recommended activities by matching the generated attribute information of the digital device and the attribute information of the external device.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: October 13, 2020
    Assignee: LG ELECTRONICS INC.
    Inventors: Sihwa Park, Juhwan Lee, Sinae Chun, Doyoung Lee
  • Patent number: 10737098
    Abstract: An ear-piece assembly includes (i) an antenna portion enclosing a transmitting antenna configured to send one or more input signals containing electrical energy to a passive implantable neural stimulator device such that the passive implantable neural stimulator generates one or more stimulation pulses suitable for stimulating a neural structure in the craniofacial region solely using the electrical energy in the input signals; and (ii) an enclosure coupled to the antenna portion, wherein enclosure is sized and shaped to be mounted on a helix portion of an ear such that, when worn by a patient, weight from the enclosure is distributed over the helix portion of the ear for the enclosure to rest thereon, wherein the enclosure includes (i) a controller module configured to provide the one or more input signals to the transmitting antenna, and (ii) a battery adapted to provide energy to the ear-piece assembly.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: August 11, 2020
    Assignee: Stimwave Technologies Incorporated
    Inventors: Laura Tyler Perryman, Chad David Andresen, Graham Patrick Greene
  • Patent number: 10733727
    Abstract: This disclosure generally pertains to methods and systems for processing electronic data obtained from imaging or other diagnostic and evaluative medical procedures. Certain embodiments relate to methods for the development of deep learning algorithms that perform machine recognition of specific features and conditions in imaging and other medical data. Another embodiment provides systems configured to detect and localize medical abnormalities on medical imaging scans by a deep learning algorithm.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: August 4, 2020
    Assignee: Qure.AI Technologies Private Limited
    Inventors: Preetham Putha, Manoj Tadepalli, Bhargava Reddy, Tarun Nimmada, Pooja Rao, Prashant Warier
  • Patent number: 10716940
    Abstract: An implant unit configured for implantation into a body of a subject is provided. The implant unit may include an antenna configured to receive a signal, and at least one pair of modulation electrodes configured to be implanted into the body of the subject in the vicinity of at least one nerve to be modulated. The at least one nerve may have a diameter less than about 2 millimeters at a modulation location, and the at least one pair of modulation electrodes may be configured to receive an applied electric signal in response to the signal received by the antenna and generate an electrical field to modulate the at least one nerve from a position spaced apart from the at least one nerve.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: July 21, 2020
    Assignee: Nyxoah SA
    Inventor: Adi Mashiach
  • Patent number: 10702445
    Abstract: The present invention provides, among other things, apparatus and methods of use for treating a subject in need of assistance with breathing. In some embodiments the subject suffers from airflow obstruction. In some embodiments, the subject suffers from chronic obstructive pulmonary disease.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: July 7, 2020
    Assignee: Apellis Holdings, LLC
    Inventors: Cedric Francois, Angus McLachlan
  • Patent number: 10675469
    Abstract: This document discusses, among other things, systems and methods for managing pain of a subject. A system includes one or more physiological sensors configured to sense a physiological signal indicative of patient brain activity. The physiological signals may include an electroencephalography signal, a magnetoencephalography signal, or a brain-evoked potential. The system may extract from the brain activity signal one or more signal metrics indicative of strength or pattern of brain electromagnetic activity associated with pain, and generate a pain score using the one or more signal metrics. The pain score can be output to a patient or a process. The system may select an electrode configuration for pain-relief electrostimulation based on the pain score, and deliver a closed-loop pain therapy according to the selected electrode configuration.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: June 9, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Elizabeth Mary Annoni, Jianwen Gu, Rosana Esteller, Bryan Allen Clark, Pramodsingh Hirasingh Thakur, Kyle Harish Srivastava
  • Patent number: 10596336
    Abstract: A ventilation system provides patient-triggered support ventilation to a spontaneously breathing patient during ongoing high frequency ventilation (HFV), and has a pneumatic unit operated by a control computer for delivery of breathing gas in response to an effort to breathe by the patient, and an oscillator for superimposing high frequency oscillation onto the breathing gas. The system further includes a bioelectric sensor that measures a bioelectric signal indicative of the patient's efforts to breathe, and the control computer controls the delivery of breathing gas in response to the patient's effort to breathe, based on this bioelectric signal. The ventilation system is hence designed for neurally triggered support ventilation during ongoing HFV, which makes the trigger mechanism of the ventilation system more precise and robust compared to known trigger mechanisms of HFV ventilation systems.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: March 24, 2020
    Assignee: Maquet Critical Care AB
    Inventors: Ake Larsson, Mario Loncar, Erik Cardelius
  • Patent number: 10596366
    Abstract: A trans mucosal neuromuscular electrical stimulation device including a mouthpiece, electrodes associated with the mouthpiece. The device and/or mouthpiece incorporates electrical circuitry operatively connecting to the electrodes to a power source and is configured to provide, in use, electrical stimulation to one or more palate and/or tongue muscles via the electrodes through the oral mucosa. The treatment regime, including the location of stimulation and the parameters used, is designed to increase resting muscle tone and/or muscle tone during sleep.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: March 24, 2020
    Assignee: SIGNIFIER MEDICAL TECHNOLOGIES LIMITED
    Inventor: Anshul Sama
  • Patent number: 10561836
    Abstract: A trans mucosal neuromuscular electrical stimulation device (1) including a mouthpiece (3, 103), electrodes (32a, 33a, 132a, 133a) associated with the mouthpiece (3, 103). The device (1) and/or mouthpiece (3, 103) incorporates electrical circuitry operatively connecting to the electrodes (32a, 33a, 132a, 133a) to a power source and is configured to provide, in use, electrical stimulation to one or more palate and/or tongue muscles via the electrodes (32a, 33a, 132a, 133a) through the oral mucosa. The treatment regime, including the location of stimulation and the parameters used, is designed to increase resting muscle tone and/or muscle tone during sleep.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: February 18, 2020
    Assignee: SIGNIFIER MEDICAL TECHNOLOGIES LIMITED
    Inventor: Anshul Sama
  • Patent number: 10561844
    Abstract: Diaphragm pacing systems and methods are disclosed for providing respiratory therapy to a patient. The diaphragm pacing systems can provide rapid insertion and deployment of pacing electrodes in critically ill patients who require intubation and invasive Positive Pressure Mechanical Ventilation (PPMV) in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation. The diaphragm pacing systems can be designed to seamlessly interface with any commercially available positive-pressure ventilatory assistance/support equipment such as is commonly in use in hospital intensive care units (ICU) for treating critically ill patients with breathing insufficiencies, pain, trauma, sepsis or neurological diseases or deficits.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: February 18, 2020
    Assignee: Lungpacer Medical Inc.
    Inventors: Ramasamy Meyyappan, Joaquin Andres Hoffer, Marcelo Baru, Bernard Coquinco, Rodrigo Andres Sandoval, Jessica Kit-Sum Tang
  • Patent number: 10561843
    Abstract: Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: February 18, 2020
    Inventor: Joaquin Andres Hoffer
  • Patent number: 10537735
    Abstract: A controller detects a cyclic cardiac event of the patient based on a signal obtained from one or more electrodes configured for placement on or near a diaphragm, and delivers an electrical stimulation therapy to a diaphragm of the patient through the one or more electrodes. The delivery of electrical stimulation therapy is timed to the detection of the cyclic cardiac event, and the electrical stimulation therapy is defined by stimulation parameters. The controller monitors a pressure associated with the intrathoracic cavity of the patient based on a signal provided by a pressure measurement source configured to provide a signal indicative of a pressure within an intrathoracic cavity, to determine whether an adjustment of one or more of the stimulation parameters is warranted.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: January 21, 2020
    Assignee: VisCardia, Inc.
    Inventors: Peter T. Bauer, Edward Chinchoy, Jay Snell
  • Patent number: 10499992
    Abstract: The present teaching relates to surgical procedure assistance. In one example, a first volume of air inside a lung is obtained based on a first image of the lung captured prior to a surgical procedure. The lung has a first shape on the first image. A second volume of air deflated from the lung is determined based on a second image of the lung captured during the surgical procedure. A second shape of the lung is estimated based on the first shape of the lung and the first air volume inside the lung and second volume of air deflated from the lung. A surgical plan is updated based on the estimated second shape of the lung.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: December 10, 2019
    Assignee: EDDA TECHNOLOGY, INC.
    Inventors: Guo-Qing Wei, Li Fan, Cheng-Chung Liang, Jianzhong Qian, Xiaolan Zeng
  • Patent number: 10493271
    Abstract: A controller delivers electrical stimulation therapy to a diaphragm through the one or more electrodes, and obtains a signal indicative of a pressure within an intrathoracic cavity from a pressure measurement source. The electrical stimulation therapy is defined by stimulation parameters. The controller obtains at least one additional signal indicative of a pressure within an intrathoracic cavity by changing at least one of the stimulation parameters, and delivering an electrical stimulation therapy to the diaphragm in accordance with the changed one of the plurality of stimulation parameters. The controller repeats the process of obtaining additional signals indicative of pressure based on a changing stimulation parameter by scanning through a range of values for the changing stimulation parameter.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: December 3, 2019
    Assignee: VisCardia, Inc.
    Inventors: Peter T. Bauer, Edward Chinchoy, Jay Snell, Patricia A. Arand
  • Patent number: 10463266
    Abstract: Methods and systems for monitoring, preventing and/or treating upper airway disorders such as apnea, dysphagia, reflux and/or snoring are described. The methods and systems monitor the upper airway disorders by processing one or more neural signals obtained from one or more upper airway afferents. Upper airway disorders are prevented and/or treated by delivering one or more stimulations to one or more reflex-related afferents, efferents, muscles, and sensory receptors to manipulate the threshold and/or trigger an upper airway reflex including, but not limited to a swallow reflex and/or a negative-pressure reflex.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: November 5, 2019
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventor: Willard Wilson
  • Patent number: 10426950
    Abstract: Methods for treating a subject for a parasympathetic bias mediated condition are provided. Aspects of the methods include modulating at least a portion of the subject's autonomic nervous system to increase the sympathetic/parasympathetic activity ratio in a manner effective to treat the subject for the parasympathetic bias mediated condition. In some instances, the subject is known to have parasympathetic bias. Also provided are devices that find use in practicing various embodiments of the methods.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: October 1, 2019
    Assignee: Palo Alto Investors
    Inventors: Anthony Joonkyoo Yun, Jeremy Thomas Yun, Eric Foster Yun
  • Patent number: 10406366
    Abstract: A lead system and method of use for treating breathing disorders by the transvenous stimulation of the phrenic nerve. The lead is implanted in a vein near one portion of the phrenic nerve.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: September 10, 2019
    Assignee: RESPICARDIA, INC.
    Inventors: Randy W. Westlund, Mark Gelfand
  • Patent number: 10406367
    Abstract: Transvascular diaphragm pacing systems (TDPS) and methods are disclosed for providing respiratory therapy to a patient. The TDPS can provide rapid insertion and deployment of endovascular pacing electrodes in critically ill patients who require intubation and invasive PPMV in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation applied to endovascular electrodes that are temporarily and reversibly inserted in central veins of the patient, such as the left subclavian vein and the superior vena cava.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: September 10, 2019
    Assignee: Lungpacer Medical Inc.
    Inventors: Ramasamy Meyyappan, Joaquin Andres Hoffer, Marcelo Baru, Bernard Coquinco, Rodrigo Andres Sandoval, Jessica Kit-Sum Tang
  • Patent number: 10376308
    Abstract: A method for treating a heart failure patient by ablating a nerve of the splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method including: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying simulation energy after the ablation and observing hemodynamic effects.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: August 13, 2019
    Assignee: Axon Therapies, Inc.
    Inventors: Howard Levin, Mark Gelfand
  • Patent number: 10369361
    Abstract: A lead for placement on a diaphragm includes a sensor assembly, a connector, and a lead body. The sensor assembly includes a housing having a first end surface and a second end surface opposite the first end surface. The first end surface is intended to contact the diaphragm. The sensor assembly includes at least one fixation structure also associated with the first end surface. The fixation structure is configured to preserve the hermetic integrity of the intrathoracic cavity. The fixation structure may extend through the diaphragm and transition to a state that forms a seal between itself and tissue of the diaphragm. Alternatively, the fixation structure may surround the sensor assembly and form a seal between itself and the surface of the diaphragm.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: August 6, 2019
    Assignee: VisCardia, Inc.
    Inventors: Peter T. Bauer, Edward Chinchoy, Jay Snell
  • Patent number: 10292610
    Abstract: Neuromodulation systems with nerve monitoring assemblies and associated devices, systems, and methods are disclosed herein. A neuromodulation system configured in accordance with some embodiments of the present technology can include, for example, a generator, a nerve monitoring assembly configured to detect electroneurogram (ENG) signals, and a neuromodulation catheter. The neuromodulation catheter can include an elongated shaft with a distal portion and a proximal portion. The distal portion of the shaft can include an array of electrodes configured to detect nerve activity from within a blood vessel of a human. The proximal portion of the shaft can include at least one connector that operably couples the electrodes to the generator and to the nerve monitoring assembly.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: May 21, 2019
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventor: Nishant R. Srivastava
  • Patent number: 10279185
    Abstract: A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's Hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the Hypoglossal nerve to stimulate at least one muscle of the tongue. Methods may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle. The stimulation load to maintain the position of the tongue may be shared by each muscle. The position of the patient's tongue may be controlled in order to prevent obstructive sleep apnea.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: May 7, 2019
    Assignee: IMTHERA MEDICAL, INC.
    Inventors: Paul M. Meadows, Marcelo G. Lima, Faisal N. Zaidi
  • Patent number: 10213160
    Abstract: An apparatus for monitoring EMG signals of a patient's laryngeal muscles includes an endotracheal tube having an exterior surface. Conductive electrodes are formed on the endotracheal tube. The conductive electrodes are configured to receive the EMG signals from the laryngeal muscles when the endotracheal tube is placed in a trachea of the patient. At least wireless sensor is formed on the endotracheal tube, and is configured to wirelessly transmit information to a processing apparatus.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: February 26, 2019
    Assignee: Medtronic Xomed, Inc.
    Inventors: David C. Hacker, Maria Charles Vijay Stanislaus, Wenjeng Li, Dwayne S. Yamasaki, William C. Brunnett, Kevin L. McFarlin, James Britton Hissong, Robert K. Vaccaro, John M. Murphy, Carla A. Pagotto, Tino Schuler
  • Patent number: 10195429
    Abstract: A method for positioning an intravascular catheter may include inserting the intravascular catheter into a venous system of a patient, wherein the catheter includes a plurality of electrodes, and multiple electrodes of the plurality of electrodes are configured to emit electrical signals; positioning a distal portion of the catheter in a first position; using one or more electrodes of the plurality of electrodes to acquire an ECG signal; based on the acquired ECG signal, adjusting the distal portion of the catheter to a second position different from the first position; identifying at least one first electrode of the plurality of electrodes to stimulate a first nerve; identifying at least one second electrode of the plurality of electrodes to stimulate a second nerve; and stimulating at least one of the first and second nerves to cause a contraction of a respiratory muscle.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: February 5, 2019
    Assignee: Lungpacer Medical Inc.
    Inventors: Viral S. Thakkar, Douglas G. Evans, Matthew J. Gani
  • Patent number: 10176572
    Abstract: A method adapted to diagnose airway obstruction in a subject is disclosed. The method comprises the following steps: providing plural cross-sectional ultrasound images of a region of the respiratory tract during the subject's normal breathing, wherein each ultrasound image has plural pixels and each pixel has a color scale value; selecting a region of interest in each ultrasound image; calculating a respective first statistic value. The pixels in each of the region of interest are identified to define a respective airspace region by the color scale values larger than or equal to the respective first statistic value. A respective width of the respiratory tract is calculated and based on the distribution of the pixels in the respective airspace region. The status about an airway obstruction in the subject is classified according to the second statistic value obtained by the calculation of the widths of the respiratory tract.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: January 8, 2019
    Assignee: AMCAD BIOMED CORPORATION
    Inventors: Argon Chen, Yi-li Lee, Chun-Hsiang Yang, Edward Chia-Hao Liu