Stimulating Respiration Function Patents (Class 607/42)
  • Patent number: 10561836
    Abstract: A trans mucosal neuromuscular electrical stimulation device (1) including a mouthpiece (3, 103), electrodes (32a, 33a, 132a, 133a) associated with the mouthpiece (3, 103). The device (1) and/or mouthpiece (3, 103) incorporates electrical circuitry operatively connecting to the electrodes (32a, 33a, 132a, 133a) to a power source and is configured to provide, in use, electrical stimulation to one or more palate and/or tongue muscles via the electrodes (32a, 33a, 132a, 133a) through the oral mucosa. The treatment regime, including the location of stimulation and the parameters used, is designed to increase resting muscle tone and/or muscle tone during sleep.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: February 18, 2020
    Assignee: SIGNIFIER MEDICAL TECHNOLOGIES LIMITED
    Inventor: Anshul Sama
  • Patent number: 10561843
    Abstract: Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: February 18, 2020
    Inventor: Joaquin Andres Hoffer
  • Patent number: 10561844
    Abstract: Diaphragm pacing systems and methods are disclosed for providing respiratory therapy to a patient. The diaphragm pacing systems can provide rapid insertion and deployment of pacing electrodes in critically ill patients who require intubation and invasive Positive Pressure Mechanical Ventilation (PPMV) in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation. The diaphragm pacing systems can be designed to seamlessly interface with any commercially available positive-pressure ventilatory assistance/support equipment such as is commonly in use in hospital intensive care units (ICU) for treating critically ill patients with breathing insufficiencies, pain, trauma, sepsis or neurological diseases or deficits.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: February 18, 2020
    Assignee: Lungpacer Medical Inc.
    Inventors: Ramasamy Meyyappan, Joaquin Andres Hoffer, Marcelo Baru, Bernard Coquinco, Rodrigo Andres Sandoval, Jessica Kit-Sum Tang
  • Patent number: 10537735
    Abstract: A controller detects a cyclic cardiac event of the patient based on a signal obtained from one or more electrodes configured for placement on or near a diaphragm, and delivers an electrical stimulation therapy to a diaphragm of the patient through the one or more electrodes. The delivery of electrical stimulation therapy is timed to the detection of the cyclic cardiac event, and the electrical stimulation therapy is defined by stimulation parameters. The controller monitors a pressure associated with the intrathoracic cavity of the patient based on a signal provided by a pressure measurement source configured to provide a signal indicative of a pressure within an intrathoracic cavity, to determine whether an adjustment of one or more of the stimulation parameters is warranted.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: January 21, 2020
    Assignee: VisCardia, Inc.
    Inventors: Peter T. Bauer, Edward Chinchoy, Jay Snell
  • Patent number: 10499992
    Abstract: The present teaching relates to surgical procedure assistance. In one example, a first volume of air inside a lung is obtained based on a first image of the lung captured prior to a surgical procedure. The lung has a first shape on the first image. A second volume of air deflated from the lung is determined based on a second image of the lung captured during the surgical procedure. A second shape of the lung is estimated based on the first shape of the lung and the first air volume inside the lung and second volume of air deflated from the lung. A surgical plan is updated based on the estimated second shape of the lung.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: December 10, 2019
    Assignee: EDDA TECHNOLOGY, INC.
    Inventors: Guo-Qing Wei, Li Fan, Cheng-Chung Liang, Jianzhong Qian, Xiaolan Zeng
  • Patent number: 10493271
    Abstract: A controller delivers electrical stimulation therapy to a diaphragm through the one or more electrodes, and obtains a signal indicative of a pressure within an intrathoracic cavity from a pressure measurement source. The electrical stimulation therapy is defined by stimulation parameters. The controller obtains at least one additional signal indicative of a pressure within an intrathoracic cavity by changing at least one of the stimulation parameters, and delivering an electrical stimulation therapy to the diaphragm in accordance with the changed one of the plurality of stimulation parameters. The controller repeats the process of obtaining additional signals indicative of pressure based on a changing stimulation parameter by scanning through a range of values for the changing stimulation parameter.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: December 3, 2019
    Assignee: VisCardia, Inc.
    Inventors: Peter T. Bauer, Edward Chinchoy, Jay Snell, Patricia A. Arand
  • Patent number: 10463266
    Abstract: Methods and systems for monitoring, preventing and/or treating upper airway disorders such as apnea, dysphagia, reflux and/or snoring are described. The methods and systems monitor the upper airway disorders by processing one or more neural signals obtained from one or more upper airway afferents. Upper airway disorders are prevented and/or treated by delivering one or more stimulations to one or more reflex-related afferents, efferents, muscles, and sensory receptors to manipulate the threshold and/or trigger an upper airway reflex including, but not limited to a swallow reflex and/or a negative-pressure reflex.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: November 5, 2019
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventor: Willard Wilson
  • Patent number: 10426950
    Abstract: Methods for treating a subject for a parasympathetic bias mediated condition are provided. Aspects of the methods include modulating at least a portion of the subject's autonomic nervous system to increase the sympathetic/parasympathetic activity ratio in a manner effective to treat the subject for the parasympathetic bias mediated condition. In some instances, the subject is known to have parasympathetic bias. Also provided are devices that find use in practicing various embodiments of the methods.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: October 1, 2019
    Assignee: Palo Alto Investors
    Inventors: Anthony Joonkyoo Yun, Jeremy Thomas Yun, Eric Foster Yun
  • Patent number: 10406366
    Abstract: A lead system and method of use for treating breathing disorders by the transvenous stimulation of the phrenic nerve. The lead is implanted in a vein near one portion of the phrenic nerve.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: September 10, 2019
    Assignee: RESPICARDIA, INC.
    Inventors: Randy W. Westlund, Mark Gelfand
  • Patent number: 10406367
    Abstract: Transvascular diaphragm pacing systems (TDPS) and methods are disclosed for providing respiratory therapy to a patient. The TDPS can provide rapid insertion and deployment of endovascular pacing electrodes in critically ill patients who require intubation and invasive PPMV in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation applied to endovascular electrodes that are temporarily and reversibly inserted in central veins of the patient, such as the left subclavian vein and the superior vena cava.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: September 10, 2019
    Assignee: Lungpacer Medical Inc.
    Inventors: Ramasamy Meyyappan, Joaquin Andres Hoffer, Marcelo Baru, Bernard Coquinco, Rodrigo Andres Sandoval, Jessica Kit-Sum Tang
  • Patent number: 10376308
    Abstract: A method for treating a heart failure patient by ablating a nerve of the splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method including: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying simulation energy after the ablation and observing hemodynamic effects.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: August 13, 2019
    Assignee: Axon Therapies, Inc.
    Inventors: Howard Levin, Mark Gelfand
  • Patent number: 10369361
    Abstract: A lead for placement on a diaphragm includes a sensor assembly, a connector, and a lead body. The sensor assembly includes a housing having a first end surface and a second end surface opposite the first end surface. The first end surface is intended to contact the diaphragm. The sensor assembly includes at least one fixation structure also associated with the first end surface. The fixation structure is configured to preserve the hermetic integrity of the intrathoracic cavity. The fixation structure may extend through the diaphragm and transition to a state that forms a seal between itself and tissue of the diaphragm. Alternatively, the fixation structure may surround the sensor assembly and form a seal between itself and the surface of the diaphragm.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: August 6, 2019
    Assignee: VisCardia, Inc.
    Inventors: Peter T. Bauer, Edward Chinchoy, Jay Snell
  • Patent number: 10292610
    Abstract: Neuromodulation systems with nerve monitoring assemblies and associated devices, systems, and methods are disclosed herein. A neuromodulation system configured in accordance with some embodiments of the present technology can include, for example, a generator, a nerve monitoring assembly configured to detect electroneurogram (ENG) signals, and a neuromodulation catheter. The neuromodulation catheter can include an elongated shaft with a distal portion and a proximal portion. The distal portion of the shaft can include an array of electrodes configured to detect nerve activity from within a blood vessel of a human. The proximal portion of the shaft can include at least one connector that operably couples the electrodes to the generator and to the nerve monitoring assembly.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: May 21, 2019
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventor: Nishant R. Srivastava
  • Patent number: 10279185
    Abstract: A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's Hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the Hypoglossal nerve to stimulate at least one muscle of the tongue. Methods may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle. The stimulation load to maintain the position of the tongue may be shared by each muscle. The position of the patient's tongue may be controlled in order to prevent obstructive sleep apnea.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: May 7, 2019
    Assignee: IMTHERA MEDICAL, INC.
    Inventors: Paul M. Meadows, Marcelo G. Lima, Faisal N. Zaidi
  • Patent number: 10213160
    Abstract: An apparatus for monitoring EMG signals of a patient's laryngeal muscles includes an endotracheal tube having an exterior surface. Conductive electrodes are formed on the endotracheal tube. The conductive electrodes are configured to receive the EMG signals from the laryngeal muscles when the endotracheal tube is placed in a trachea of the patient. At least wireless sensor is formed on the endotracheal tube, and is configured to wirelessly transmit information to a processing apparatus.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: February 26, 2019
    Assignee: Medtronic Xomed, Inc.
    Inventors: David C. Hacker, Maria Charles Vijay Stanislaus, Wenjeng Li, Dwayne S. Yamasaki, William C. Brunnett, Kevin L. McFarlin, James Britton Hissong, Robert K. Vaccaro, John M. Murphy, Carla A. Pagotto, Tino Schuler
  • Patent number: 10195429
    Abstract: A method for positioning an intravascular catheter may include inserting the intravascular catheter into a venous system of a patient, wherein the catheter includes a plurality of electrodes, and multiple electrodes of the plurality of electrodes are configured to emit electrical signals; positioning a distal portion of the catheter in a first position; using one or more electrodes of the plurality of electrodes to acquire an ECG signal; based on the acquired ECG signal, adjusting the distal portion of the catheter to a second position different from the first position; identifying at least one first electrode of the plurality of electrodes to stimulate a first nerve; identifying at least one second electrode of the plurality of electrodes to stimulate a second nerve; and stimulating at least one of the first and second nerves to cause a contraction of a respiratory muscle.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: February 5, 2019
    Assignee: Lungpacer Medical Inc.
    Inventors: Viral S. Thakkar, Douglas G. Evans, Matthew J. Gani
  • Patent number: 10176572
    Abstract: A method adapted to diagnose airway obstruction in a subject is disclosed. The method comprises the following steps: providing plural cross-sectional ultrasound images of a region of the respiratory tract during the subject's normal breathing, wherein each ultrasound image has plural pixels and each pixel has a color scale value; selecting a region of interest in each ultrasound image; calculating a respective first statistic value. The pixels in each of the region of interest are identified to define a respective airspace region by the color scale values larger than or equal to the respective first statistic value. A respective width of the respiratory tract is calculated and based on the distribution of the pixels in the respective airspace region. The status about an airway obstruction in the subject is classified according to the second statistic value obtained by the calculation of the widths of the respiratory tract.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: January 8, 2019
    Assignee: AMCAD BIOMED CORPORATION
    Inventors: Argon Chen, Yi-li Lee, Chun-Hsiang Yang, Edward Chia-Hao Liu
  • Patent number: 10092235
    Abstract: Disclosed is a method for interacting with the nervous system. The method includes detecting signals associated with a biological function at one or more sensors. It also includes processing the signals to create a representation thereof, delivering effector responses based on the representations, and controlling a physical process.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: October 9, 2018
    Assignee: Incyphae Inc.
    Inventors: Sanjiv M. Narayan, Ruchir Sehra
  • Patent number: 10058701
    Abstract: A trans mucosal neuromuscular electrical stimulation device (1) including a mouthpiece (3, 103) and electrodes (32a, 33a, 132a, 133a) associated with the mouthpiece (3, 103). The device (1) and/or mouthpiece (3, 103) incorporates electrical circuitry operatively connecting the electrodes (32a, 33a, 132a, 133a) to a power source and is configured to provide, in use, electrical stimulation to one or more palate and/or tongue muscles via the electrodes (32a, 33a, 132a, 133a) through the oral mucosa. The treatment regime, including the location of stimulation and the parameters used, is designed to increase resting muscle tone and/or muscle tone during sleep.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: August 28, 2018
    Assignee: SNOOZEAL LIMITED
    Inventor: Anshul Sama
  • Patent number: 10039920
    Abstract: A method for positioning an intravascular catheter may include inserting the intravascular catheter into a venous system of a patient, wherein the catheter includes a plurality of electrodes, and multiple electrodes of the plurality of electrodes are configured to emit electrical signals; positioning a distal portion of the catheter in a first position; using one or more electrodes of the plurality of electrodes to acquire an ECG signal; based on the acquired ECG signal, adjusting the distal portion of the catheter to a second position different from the first position; identifying at least one first electrode of the plurality of electrodes to stimulate a first nerve; identifying at least one second electrode of the plurality of electrodes to stimulate a second nerve; and stimulating at least one of the first and second nerves to cause a contraction of a respiratory muscle.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: August 7, 2018
    Assignee: Lungpacer Medical, Inc.
    Inventors: Viral S. Thakkar, Douglas G. Evans, Matthew J. Gani
  • Patent number: 9999768
    Abstract: A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: June 19, 2018
    Assignee: Respicardia, Inc.
    Inventors: Mark Gelfand, Kristofer J. James, Randy W. Westlund, Antonis Panteleon, Todd P. Goblish, Mark C. Lynn
  • Patent number: 9993652
    Abstract: A device for conveying power from a location external to a subject to a location within the subject may include a flexible carrier and an adhesive on a first side of the carrier. A coil of electrically conductive material may be associated with the flexible carrier. A mechanical connector may be associated with the carrier opposite the adhesive, wherein the mechanical connector is configured to retain a housing and permit the housing to rotate relative to the flexible carrier. At least one electrical portion may be associated with the carrier in a manner permitting electrical connection to be maintained between the flexible carrier and the housing as the housing is rotated.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 12, 2018
    Assignee: NYXOAH SA
    Inventors: Adi Mashiach, Tim Ruytjens
  • Patent number: 9956132
    Abstract: The present invention provides, among other things, apparatus and methods of use for treating a subject in need of assistance with breathing. In some embodiments the subject suffers from airflow obstruction. In some embodiments, the subject suffers from chronic obstructive pulmonary disease.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: May 1, 2018
    Assignee: Apellis Holdings, LLC
    Inventors: Cedric Francois, Angus McLachlan
  • Patent number: 9878159
    Abstract: An implant unit according to some embodiments may include a flexible carrier, at least one pair of modulation electrodes on the flexible carrier, and at least one implantable circuit in electrical communication with the at least one pair of modulation electrodes. The at least one pair of modulation electrodes and the at least one circuit may be configured for implantation through derma on an underside of a subject's chin and for location proximate to terminal fibers of the medial branch of the subject's hypoglossal nerve, such that an electric field extending from the at least one pair of modulation electrodes can modulate one or more of the terminal fibers of the medial branch of the hypoglossal nerve.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: January 30, 2018
    Inventor: Adi Mashiach
  • Patent number: 9872989
    Abstract: Adaptive systems and methods for automatically determining and continuously updating stimulation parameters for adjusting ventilation to accommodate a patient's specific physiology, metabolic needs, and muscle state are disclosed herein. Having a closed loop implementation, the system may comprise a controller including a neuromorphic controlled adaptive feed-forward Pattern Generator/Pattern Shaper (PG/PS) assembly, which controls respiratory muscle movement using electrical stimulation. This PG/PS assembly comprises a biomimetic design where the pattern generator includes a neural network mimicking the simplified connectivity pattern of respiratory related neurons in the brain stem to produce a rhythmic breathing pattern frequency and the pattern shaper includes a neural network mimicking the simplified connectivity pattern of neurons to produce a stimulus control signal.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: January 23, 2018
    Assignee: The Florida International University Board of Trustees
    Inventor: Ranu Jung
  • Patent number: 9849283
    Abstract: A method and system for creating shear stress and endothelial mechanotransduction through neuromuscular stimulation of the muscle pump. Chronic application a minimum of 30 days triggers the autocrine and paracrine processes which elevates production of vasoactive substances including nitric oxide, prostacyclin, superoxide dismutase, thrombomodulin, glutathion, Krupple-like factor 2 and many others. Chronic application also promotes angiogenesis and development of collateral circulation. This is a cost-effective, non-invasive, drug-free therapy to treat vascular dysfunction and ameliorate or reverse its effects on cardiovascular health.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: December 26, 2017
    Inventor: John M. Owen
  • Patent number: 9833613
    Abstract: A trans mucosal neuromuscular electrical stimulation device (1) including a mouthpiece (3, 103), electrodes (32a, 33a, 132a, 133a) associated with the mouthpiece (3, 103). The device (1) and/or mouthpiece (3, 103) incorporates electrical circuitry operatively connecting to the electrodes (32a, 33a, 132a, 133a) to a power source and is configured to provide, in use, electrical stimulation to one or more palate and/or tongue muscles via the electrodes (32a, 33a, 132a, 133a) through the oral mucosa. The treatment regime, including the location of stimulation and the parameters used, is designed to increase resting muscle tone and/or muscle tone during sleep.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: December 5, 2017
    Assignee: Snoozeal Limited
    Inventor: Anshul Sama
  • Patent number: 9814452
    Abstract: A surgical instrument including a housing, an endoscopic portion, a shaft portion, and an end effector is disclosed. The endoscopic portion extends distally from the housing and defines a longitudinal axis. The shaft portion is selectively connectable to a distal end of the endoscopic portion. The end effector is selectively connectable to a distal end of the shaft portion.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: November 14, 2017
    Assignee: Covidien LP
    Inventors: Michael A. Zemlok, David Racenet, Adam Ross
  • Patent number: 9737708
    Abstract: Provided is a respiratory abnormality improvement apparatus capable of effectively improving respiratory abnormality during sleep. The present invention is a respiratory abnormality improvement apparatus for applying a stimulus signal generated in a stimulus generating unit to a patient as an electric stimulus. Here, the apparatus includes a respiration detection unit for detecting a respiratory condition of the patient. Particularly, the stimulus generating unit is so configured that a first stimulus signal generated at a current level preset at a given time, and a second stimulus signal of a current level different from that of the first stimulus signal are generated as stimulus signals to an electrode member worn by the patient based on a detection signal from the respiration detection unit when the patient has been judged to be under a respiratory abnormality condition.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: August 22, 2017
    Assignee: Techno Link Co., Ltd.
    Inventor: Tatsuyuki Kobayashi
  • Patent number: 9724521
    Abstract: In some examples, one or more processors determine characteristics of frequency components of a sensed bioelectrical signal. In response to determining the characteristics, the one or more processors determine therapy parameters for frequency components of a stimulation signal. The one or more processors may determine the therapy parameters based on the characteristics of the frequency components of the sensed bioelectrical signal. As another example, the one or more processors may determine the therapy parameters based on received information after the characteristics of the frequency components of the sensed bioelectrical signal are displayed to a user.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: August 8, 2017
    Assignee: Medtronic, Inc.
    Inventors: Peng Cong, Timothy J. Denison, Gabriela C. Molnar, Forrest C. M. Pape, Scott R. Stanslaski, Wesley A. Santa
  • Patent number: 9694185
    Abstract: An implantable system, and methodology, for improving a heart's hemodynamic performance featuring (a) bimodal electrodes placeable on the diaphragm, out of contact with the heart, possessing one mode for sensing cardiac electrical activity, and another for applying cardiac-cycle-synchronized, asymptomatic electrical stimulation to the diaphragm to trigger biphasic, diaphragmatic motion, (b) an accelerometer adjacent the electrodes for sensing both heart sounds, and stimulation-induced diaphragmatic motion, and (c) circuit structure, connected both to the electrodes and the accelerometer, operable, in predetermined timed relationships to the presences of valid V-events noted in one of sensed electrical and sensed mechanical, cardiac activity, to deliver diaphragmatic stimulation.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: July 4, 2017
    Assignee: VisCardia, Inc.
    Inventor: Peter T. Bauer
  • Patent number: 9675800
    Abstract: The embodiments of the invention provide a snore stopping device. The snore stopping device comprises a sleep information acquisition module used for acquiring actual sleep information of a user; a processing module used for comparing the actual sleep information acquired by the sleep information acquisition module with a normal sleep information range, and capable of generating a trigger signal when the actual sleep information goes beyond the normal sleep information range; and an electric stimulation module used for contacting the skin of the user and generating an electric stimulation signal according to the trigger signal. The snore stopping device can effectively cause the snoring user to change his/her sleeping posture, so as to achieve the snore stopping effect.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: June 13, 2017
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Yanjun Li, Yingzi Wang
  • Patent number: 9669148
    Abstract: A method for treatment of COPD, hypertension, and left ventricular hypertrophy, and chronic hypoxia including creation of an artificial arterio-venous fistula and installation of a flow mediating device proximate the fistula. The flow mediating device is operated to limit flow as medically indicated to provide the optimum amount of bypass flow.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: June 6, 2017
    Assignee: ROX Medical, Inc.
    Inventors: Rodney A. Brenneman, J. Christopher Flaherty
  • Patent number: 9656076
    Abstract: A method, device and/or system for generating arbitrary waveforms of a desired shape that can be used for generating a stimulation pulse for medical purposes such as for spinal cord stimulation therapy, including the option of using such arbitrary waveforms for charge balancing purposes.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 23, 2017
    Assignee: Nuvectra Corporation
    Inventors: Stephen C. Trier, Jeffrey A. Weisgarber, Richard J. Polefko
  • Patent number: 9656082
    Abstract: A method of developing a respiration pacing signal includes detecting respiration and movement activity in an implanted patient and developing corresponding respiration and movement signals. A respiration pacing signal is synchronized with the detected respiration activity and delivered to respiration neural tissue of the implanted patient to promote breathing of the implanted patient. A plurality of respiration sensing modes are used that reflect activity of the movement signal over time to optimize system power consumption over time, including: i. an active respiration mode when the movement signal is either actively changing or remains unchanged for a brief period less than some reduced activity period, wherein the respiration signal is measured continuously, and ii. a plurality of reduced activity respiration modes when the movement signal has remained unchanged for the reduced activity period, wherein the respiration signal is measured only during a limited respiration sampling period.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: May 23, 2017
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventor: Christian Denk
  • Patent number: 9656083
    Abstract: A method for titrating a stimulation parameter for one or more electrode contacts in a system for stimulating a hypoglossal nerve of a patient includes activating one of the one or more electrode contacts to stimulate the hypoglossal nerve of the patient, obtaining a first and/or second physiological measurement from the patient, comparing the first and/or second physiological measurement to a first and/or second predetermined target value, adjusting a stimulation parameter for the one of the one or more electrode contacts if the first and/or second physiological measurement differs from the first and/or second predetermined target value.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: May 23, 2017
    Assignee: IMTHERA MEDICAL, INC.
    Inventors: Paul M. Meadows, Marcelo G. Lima, Faisal N. Zaidi, Jasper Benke
  • Patent number: 9623248
    Abstract: At least one of a medical device, such as an implantable medical device, and a programming device determines values for one or more metrics that indicate the quality of a patient's sleep. Sleep efficiency, sleep latency, and time spent in deeper sleep states are example sleep quality metrics for which values may be determined. In some embodiments, determined sleep quality metric values are associated with a current therapy parameter set. In some embodiments, a programming device presents sleep quality information to a user based on determined sleep quality metric values. A clinician, for example, may use the sleep quality information presented by the programming device to evaluate the effectiveness of therapy delivered to the patient by the medical device, to adjust the therapy delivered by the medical device, or to prescribe a therapy not delivered by the medical device in order to improve the quality of the patient's sleep.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: April 18, 2017
    Assignee: Medtronic, Inc.
    Inventors: Kenneth T. Heruth, Keith A. Miesel
  • Patent number: 9623239
    Abstract: The present invention provides, among other things, apparatus and methods of use for treating a subject in need of assistance with breathing. In some embodiments the subject suffers from airflow obstruction. In some embodiments, the subject suffers from chronic obstructive pulmonary disease.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: April 18, 2017
    Assignee: Apellis Holdings, LLC
    Inventors: Cedric Francois, Angus McLachlan
  • Patent number: 9555247
    Abstract: Devices and methods for treating obstructive sleep apnea by first performing an assessment of the patient that involves observing the patient's upper airway during a tongue protrusion maneuver. The assessment may, for example, be done using endoscopy to observe the upper airway while the patient is awake in the supine position. An adequate response of the upper airway during the tongue protrusion maneuver is indicative of likely therapeutic success with hypoglossal nerve stimulation, and may be used for making clinical decisions. The principles of the present invention may be applied to other therapeutic interventions for OSA involving the upper airway.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: January 31, 2017
    Assignee: CYBERONICS, INC.
    Inventors: Wondimeneh Tesfayesus, Stephen L. Bolea, Peter R. Eastwood, David R. Hillman
  • Patent number: 9539425
    Abstract: A system for treating medical conditions by neuromodulation of one or more target sites in the nervous system. In certain embodiments, at least one of the target sites is the medial thalamic region, including the intralaminar nucleus and the adjacent white and grey matter. In certain embodiments, where there is more than one target site, the other target sites is elsewhere in the nervous system, including the globus pallidus interna, subthalamic nucleus, corpus callosum, cerebellum, cerebral cortex (including the premotor cortex, motor cortex, and sensory cortex), ventral striatum, lateral thalamus, substantia nigra, and pedunculopontine nuclei. The medical conditions include movement disorders or improvement of movement function, stroke, neuropsychiatric or neuropsychologic disorders, neurodevelopmental disorders, and pain. Methods for treating medical conditions by neuromodulation of the intralaminar nuclei either alone or in combination with another target site(s) is also provided.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: January 10, 2017
    Assignees: Intelect Medical, Inc., The Cleveland Clinic Foundation, Cornell Research Foundation, Inc.
    Inventors: Ali Rezai, Nicholas Schiff, Scott Kokones, Andre Machado, Sierra Farris
  • Patent number: 9498625
    Abstract: An implantable system, and methodology, for improving a heart's hemodynamic performance featuring (a) bimodal electrodes placeable on the diaphragm, out of contact with the heart, possessing one mode for sensing cardiac electrical activity, and another for applying cardiac-cycle-synchronized, asymptomatic electrical stimulation to the diaphragm to trigger biphasic, diaphragmatic motion, (b) an accelerometer adjacent the electrodes for sensing both heart sounds, and stimulation-induced diaphragmatic motion, and (c) circuit structure, connected both to the electrodes and the accelerometer, operable, in predetermined timed relationships to the presences of valid V-events noted in one of sensed electrical and sensed mechanical, cardiac activity, to deliver diaphragmatic stimulation.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: November 22, 2016
    Assignee: VisCardia, Inc.
    Inventor: Peter T. Bauer
  • Patent number: 9486152
    Abstract: A medical system (100) is disclosed that provides a respiratory-based control of at least one medical procedure. In this regard, the medical system (100) includes one or more appropriate sensors (108) for providing respiratory data on a patient (104). This respiratory data is utilized by respiration assessment logic (116) to determine if the respiratory data has exceeded one or more respiration thresholds and which may be equated with a “sudden” respiratory event. Identification of such a sudden respiratory event by the logic (116) results in the suspension of the noted medical procedure. Patient respiration data may also be displayed, for instance in a color that depends upon its magnitude or level.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: November 8, 2016
    Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
    Inventors: Michael W. Craven, Timothy R. Jarvis
  • Patent number: 9415218
    Abstract: This disclosure provides non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries. In certain embodiments the method involves administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces the desired locomotor activity.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: August 16, 2016
    Assignee: The Regents of the University Of California
    Inventors: V. Reggie Edgerton, Yury Gerasimenko, Roland R. Roy, Daniel C. Lu
  • Patent number: 9415215
    Abstract: A method for delivering energy as a function of degree coupling may utilize an external unit configured for location external to a body of a subject and at least one processor associated with the implant unit and configured for electrical communication with a power source. The method may determine a degree of coupling between the primary antenna and a secondary antenna associated with the implant unit, and regulate delivery of power to the implant unit based on the degree of coupling between the primary antenna and the secondary antenna.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: August 16, 2016
    Assignee: NYXOAH SA
    Inventor: Adi Mashiach
  • Patent number: 9415216
    Abstract: A method for delivering energy as a function of degree coupling may utilize an external unit configured for location external to a body of a subject and at least one processor associated with the implant unit and configured for electrical communication with a power source. The method may determine a degree of coupling between the primary antenna and a secondary antenna associated with the implant unit, and regulate delivery of power to the implant unit based on the degree of coupling between the primary antenna and the secondary antenna.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: August 16, 2016
    Assignee: NYXOAH SA
    Inventor: Adi Mashiach
  • Patent number: 9393417
    Abstract: A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable pressure sensor, and a pressure analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable pressure sensor is configured to be implanted in the cervical region and to detect pressure changes in the cervical region caused by laryngeal vibrations. The pressure sensor is configured to generate sensed pressure values. The pressure analyzer is configured to analyze the sensed pressure values generated by the pressure sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed pressure values.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: July 19, 2016
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Shantha Arcot-Krishnamurthy, Barun Maskara
  • Patent number: 9370657
    Abstract: A device and method is provided for biasing lung volume by electrically stimulating tissue associated with the diaphragm or phrenic nerve at a low level.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: June 21, 2016
    Assignee: RMX, LLC
    Inventors: Amir J. Tehrani, David Ligon, Chang Lee, Rose Province, Amy Michelle Goodman
  • Patent number: 9326816
    Abstract: Neuromodulation systems with nerve monitoring assemblies and associated devices, systems, and methods are disclosed herein. A neuromodulation system configured in accordance with some embodiments of the present technology can include, for example, a generator, a nerve monitoring assembly configured to detect electroneurogram (ENG) signals, and a neuromodulation catheter. The neuromodulation catheter can include an elongated shaft with a distal portion and a proximal portion. The distal portion of the shaft can include an array of electrodes configured to detect nerve activity from within a blood vessel of a human. The proximal portion of the shaft can include at least one connector that operably couples the electrodes to the generator and to the nerve monitoring assembly.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 3, 2016
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventor: Nishant R. Srivastava
  • Patent number: 9314641
    Abstract: A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's Hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the Hypoglossal nerve to stimulate at least one muscle of the tongue. Methods may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle. The stimulation load to maintain the position of the tongue may be shared by each muscle. The position of the patient's tongue may be controlled in order to prevent obstructive sleep apnea.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: April 19, 2016
    Assignee: IMTHERA MEDICAL, INC.
    Inventors: Paul M. Meadows, Marcelo G. Lima, Faisal N. Zaidi
  • Patent number: 9295829
    Abstract: Strain relief loops are forced by being formed into medical leads such that a body of the lead imposes a force to regain the loop if the loop has been disturbed. Because the strain relief loop is forced, the surgeon implanting the medical lead is not required to create the strain relief loop as a step in the implantation procedure. Forcing the strain relief loop ensures that the strain relief is achieved. The forced strain relief loop also ensures that the loop is present to reduce heating at the electrodes of the medical caused by exposure to excessive radiofrequency energy. The forced strain relief loop may be created by heating the lead body while held in the loop configuration by a mold to cause the loop configuration to persist once the medical lead is removed from the mold.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: March 29, 2016
    Assignee: MEDTRONIC, INC.
    Inventors: Spencer M. Bondhus, Bryan D. Stem