Stimulating Respiration Function Patents (Class 607/42)
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Patent number: 8876727Abstract: A method and system of detecting phrenic nerve stimulation in a patient that includes detecting an activation event, obtaining a heart sound signal of a patient from an implanted heart sound sensor, determining that an electrical stimulation has been applied to the patient, in response to detecting the activation event, monitoring a portion of the heart sound signal, the portion defined by a predetermined window after the application of the electrical stimulation, and determining whether phrenic nerve stimulation occurred based on the portion of the heart sound signal.Type: GrantFiled: May 17, 2012Date of Patent: November 4, 2014Assignee: Medtronic, Inc.Inventors: Xusheng Zhang, Jeffrey M. Gillberg, Thomas J. Mullen, Paul J. DeGroot
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Publication number: 20140323839Abstract: The present invention describes an apparatus, a systems and a method for the treatment of obstructive sleep apnea. the treatment involves monitoring the position of the tongue and/or the force exerted by the tongue an electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position.Type: ApplicationFiled: May 20, 2014Publication date: October 30, 2014Applicant: Huntington Medical Research InstitutesInventor: Douglas B. McCreery
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Publication number: 20140316483Abstract: Embodiments of the present invention relate to a non-invasive stimulatory adjustment of the body's own self-repair-system using a plurality of electrons. In particular, embodiments of the present invention relate to a plurality of electrons for use in the restoration of a patient's health, preferably a human patient's health in a number of medical conditions. Moreover, embodiments of the present invention relate to a method of treatment using a plurality of electrons for use in the restoration of a patient's health, preferably a human patient's health. Moreover, embodiments of the present invention relate to a method of stimulatory adjustment of the body's own self-repair system using a plurality of electrons.Type: ApplicationFiled: April 28, 2014Publication date: October 23, 2014Applicant: Fenzian Ltd.Inventor: James COLTHURST
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Patent number: 8855771Abstract: Devices and methods for treating obstructive sleep apnea by first performing an assessment of the patient that involves observing the patient's upper airway during a tongue protrusion maneuver. The assessment may, for example, be done using endoscopy to observe the upper airway while the patient is awake in the supine position. An adequate response of the upper airway during the tongue protrusion maneuver is indicative of likely therapeutic success with hypoglossal nerve stimulation, and may be used for making clinical decisions. The principles of the present invention may be applied to other therapeutic interventions for OSA involving the upper airway.Type: GrantFiled: August 8, 2011Date of Patent: October 7, 2014Assignee: Cyberonics, Inc.Inventors: Wondimeneh Tesfayesus, Stephen L. Bolea, Peter R. Eastwood, David R. Hillman
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Patent number: 8844537Abstract: A system and method for controlling a device to alleviate sleep apnea comprises determining whether a user of the device is asleep by a microcontroller operatively connected to the device. Using a sensor operatively connected to the microcontroller, it is determined whether a breathing anomaly of the user is detected while the user is asleep. An electromagnet operatively connected to the device generates an electromagnetic field to widen an airway of the user in response to detecting the breathing anomaly while the user is asleep.Type: GrantFiled: October 13, 2010Date of Patent: September 30, 2014Inventor: Michael T. Abramson
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Publication number: 20140261449Abstract: An embodiment of a collar includes first and second pressure surfaces, and first and second sealing surfaces. The first pressure surface is configured for disposal over a first region of a throat of a subject having an airway, and the first sealing surface is configured to form around the first pressure surface a first seal with a first region of a neck of the subject. And the second pressure surface is configured for disposal over a second region of the throat, and the second sealing surface is configured to form around the second pressure surface a second seal with a second region of the neck. For example, the collar can be configured to generate multiple negative-pressure regions to treat a subject's sleep apnea.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Inventors: Roderick A. HYDE, Kenneth G. CALDEIRA, Lowell L. WOOD, JR., Dennis J. RIVET, Michael A. SMITH
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Publication number: 20140277252Abstract: A system includes an apparatus and a controller, according to an embodiment. The apparatus is configured to maintain an airway of a subject open while the subject is sleeping by applying to the airway a pressure having a magnitude, and the controller is configured to cause the apparatus to change the magnitude of the pressure over a period that begins at a settable start time. For example, the system can be configured to treat a subject's sleep apnea with positive or negative pressure, and to function as an alarm clock by beginning to change the pressure magnitude at a settable start time, and to continue changing the pressure over a period with a settable duration (or settable stop time) to gently awaken the subject by the end of the period.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: ELWHA LLCInventor: Elwha LLC
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Patent number: 8838245Abstract: A system and method for treating and/or preventing is described for treating periodic breathing characterized by cyclical hyperventilation and hypoventilation, examples of which include Cheyne-Stokes respiration and central sleep apnea. The system could also be used in the treatment of other conditions involving an impairment of respiratory drive.Type: GrantFiled: April 22, 2013Date of Patent: September 16, 2014Assignee: Cardiac Pacemakers, Inc.Inventors: Zheng Lin, Kenneth C. Beck, Jonathan Kwok, Kent Lee, Yachuan Pu, Jeffrey E. Stahmann
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Patent number: 8831730Abstract: A device for powering an implant within a body of a subject from a location external to the subject, wherein the implant requires a threshold rate of power increase in order to operate in at least one mode, may include an antenna configured to wirelessly transmit energy to the implant. The device may also include a power storage unit configured to store energy from a power source incapable of delivering the threshold rate of power increase to enable the implant unit to operate in the at least one mode and a power release unit configured to release a pulse of energy from the power storage unit to the antenna after the power storage unit collects an amount of energy sufficient to enable the implant unit to operate in the at least one mode.Type: GrantFiled: October 22, 2013Date of Patent: September 9, 2014Assignee: Nyxoah SAInventors: Adi Mashiach, Carsten Mueller
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Publication number: 20140236255Abstract: A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's Hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the Hypoglossal nerve to stimulate at least one muscle of the tongue. Methods may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle. The stimulation load to maintain the position of the tongue may be shared by each muscle. The position of the patient's tongue may be controlled in order to prevent obstructive sleep apnea.Type: ApplicationFiled: April 24, 2014Publication date: August 21, 2014Applicant: IMTHERA MEDICAL, INC.Inventors: Paul M. Meadows, Marcelo G. Lima, Faisal N. Zaidi
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Patent number: 8812113Abstract: A device according to some embodiments may include a housing configured for location external to a body of a subject. The device may also include at least one processor associated with the housing and configured to communicate with a circuit implanted in the subject within proximity to a tongue of the subject, wherein the circuit is in electrical communication with at least one electrode, receive a physiological signal from the subject via the circuit, and send a control signal to the implanted circuit in response to the physiological signal, wherein the control signal is predetermined to activate neuromuscular tissue within the tongue.Type: GrantFiled: September 30, 2013Date of Patent: August 19, 2014Assignee: Nyxoah SAInventor: Adi Mashiach
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Patent number: 8812112Abstract: Devices, systems and methods for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease wherein the treatment includes stimulating selected nerve fibers responsible for smooth muscle dilation at a selected region within a patient's neck, thereby reducing the magnitude of constriction of bronchial smooth muscle.Type: GrantFiled: March 20, 2009Date of Patent: August 19, 2014Assignee: Electrocore, LLCInventors: Joseph P. Errico, James R. Pastena, Steven Mendez, Hecheng Hu, Arthur Ross, Bruce Simon
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Publication number: 20140228905Abstract: A method of treating a patient, comprising: sensing a biological parameter indicative of respiration; analyzing the biological parameter to identify a respiratory cycle; identifying an inspiratory phase of the respiratory cycle; and delivering stimulation to a hypoglossal nerve of the patient, wherein stimulation is delivered if a duration of the inspiratory phase of the respiratory cycle is greater than a predetermined portion of a duration of the entire respiratory cycle.Type: ApplicationFiled: February 11, 2014Publication date: August 14, 2014Applicant: CYBERONICS, INC.Inventor: Stephen L. BOLEA
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Patent number: 8805511Abstract: A medical device and associated method detect ischemia using stimulation delivered to induce respiration. A spontaneous breathing response to the stimulation-induced respiration is determined. Ischemia is detected in response to the spontaneous breathing response. The spontaneous breathing response is measured as a response to adjusting a parameter controlling the stimulation.Type: GrantFiled: July 27, 2011Date of Patent: August 12, 2014Assignee: Medtronic, Inc.Inventors: Mustafa Karamanoglu, Vincent E. Splett, Nancy J. Rakow, Linnea R. Lentz
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Publication number: 20140200623Abstract: A method of using an airway treatment system for treating a dorsal displacement disorder in a horse includes detecting an elevated activity level of the horse using one or more treatment sensors, generating a treatment signal based on the detected elevated activity level, using a pacemaker processor, to strengthen one or more muscles involved in displacing a laryngeal anatomical structure relative to an airway of the horse, and using one or more stimulation electrodes, configured to interface with tissue of the horse, to deliver the treatment signal to the tissue of the horse to maintain an unobstructed airway.Type: ApplicationFiled: March 17, 2014Publication date: July 17, 2014Applicants: Cornell University, MED-EL Elektromedizinische Geraete GmbHInventors: Werner Lindenthaler, Norm G. Ducharme
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Patent number: 8781575Abstract: A method for providing a resuscitating treatment of a human being, which has the following actions sensing human muscle activity, human breathing activity, human neural activity or human cerebral activity, determining whether the human being is in a state of developing apnoea by a processing unit based on the sensing, provoking an induced aspiration reflex by a resuscitating stimulation of a respiratory area of a human brain stem by providing a stimulus with a stimulation device to a location distant from the respiratory area of the human brain stem upon the processing unit determining the state of developing apnoea, the location being a nasal filter of the human being or a nasopharyngeal area of the human being.Type: GrantFiled: September 6, 2013Date of Patent: July 15, 2014Assignee: NasoPhlex B.V.Inventors: Gerrit Johannis de Vos, Zoltán Tomori
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Patent number: 8781558Abstract: The system and method of the present application includes an image guided radiation therapy (IGRT) system, combined with a medical ventilator, to form a closed-loop system to optimize treatment of a tumor for patients who cannot comply with a normal respiratory management procedure. The ventilator may be used to generate respiratory maneuvers to facilitate clean images for dose planning, so that clinicians can more clearly visualize a target with fewer of the image artifacts associated with respiratory motion. The combined IGRT and ventilation systems approach facilitates treatment of specific organs most susceptible to respiratory motion artifact, and helps minimize the doses to the heart in left-breast treatments. Improved positioning of the anatomical target structures for exposure to external beam radiation may be accomplished through combinations of respiratory-gating, respiratory pause, and selective right or left lung mechanical ventilator techniques.Type: GrantFiled: November 7, 2011Date of Patent: July 15, 2014Assignee: General Electric CompanyInventor: Russell James Kuzelka
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Publication number: 20140188185Abstract: Devices and methods for treating obstructive sleep apnea by first performing an assessment of the patient that involves observing the patient's upper airway during a tongue protrusion maneuver. The assessment may, for example, be done using endoscopy to observe the upper airway while the patient is awake in the supine position. An adequate response of the upper airway during the tongue protrusion maneuver is indicative of likely therapeutic success with hypoglossal nerve stimulation, and may be used for making clinical decisions. The principles of the present invention may be applied to other therapeutic interventions for OSA involving the upper airway.Type: ApplicationFiled: August 8, 2011Publication date: July 3, 2014Inventors: Wondimeneh Tesfayesus, Stephen L. Bolea, Peter R. Eastwood, David R. Hillman
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Patent number: 8768457Abstract: A method for providing a resuscitating treatment of a human being, which has the following actions sensing human muscle activity, human breathing activity, human neural activity or human cerebral activity, determining whether the human being is in a state of developing apnoea by a processing unit based on the sensing, provoking an induced aspiration reflex by a resuscitating stimulation of a respiratory area of a human brain stem by providing a stimulus with a stimulation device to a location distant from the respiratory area of the human brain stem upon the processing unit determining the state of developing apnoea, the location being a nasal filter of the human being or a nasopharyngeal area of the human being.Type: GrantFiled: September 6, 2013Date of Patent: July 1, 2014Assignee: NasoPhlex B.V.Inventors: Gerrit Johannis de Vos, Zoltán Tomori
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Publication number: 20140172040Abstract: An implantable system, and methodology, for improving a heart's hemodynamic performance featuring (a) bimodal electrodes placeable on the diaphragm, out of contact with the heart, possessing one mode for sensing cardiac electrical activity, and another for applying cardiac-cycle-synchronized, asymptomatic electrical stimulation to the diaphragm to trigger biphasic, diaphragmatic motion, (b) an accelerometer adjacent the electrodes for sensing both heart sounds, and stimulation-induced diaphragmatic motion, and (c) circuit structure, connected both to the electrodes and the accelerometer, operable, in predetermined timed relationships to the presences of valid V-events noted in one of sensed electrical and sensed mechanical, cardiac activity, to deliver diaphragmatic stimulation.Type: ApplicationFiled: December 16, 2013Publication date: June 19, 2014Applicant: INOVISE MEDICAL, INC.Inventor: Peter T. Bauer
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Patent number: 8755890Abstract: The present invention provides a method of affecting physiological disorders by stimulating a specific location along the sympathetic nerve chain. Preferably, the present invention provides a method of affecting a variety of physiological disorders or pathological conditions by placing an electrode adjacent to or in communication with at least one ganglion along the sympathetic nerve chain and stimulating the at least one ganglion until the physiological disorder or pathological condition has been affected.Type: GrantFiled: August 28, 2012Date of Patent: June 17, 2014Assignee: The Cleveland Clinic FoundationInventor: Ali R. Rezai
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Patent number: 8755891Abstract: Methods and devices for treating anaphylaxis, anaphylactic shock, bronchial constriction, and/or asthma include providing an electrical impulse to a selected region of the vagus nerve of a patient suffering from anaphylaxis to block and/or modulate nerve signals that would regulate the function of, for example, myocardial tissue, vasodilation/constriction and/or pulmonary tissue.Type: GrantFiled: July 8, 2013Date of Patent: June 17, 2014Assignee: Electrocore, LLCInventors: Joseph P. Errico, Steven Mendez
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Patent number: 8755889Abstract: A method and apparatus stimulating a vagus nerve of a patient. The apparatus includes a pulse generator having an adjustable pulse output parameter and adapted to be electrically coupled to the vagus nerve. The pulse generator generates pulses for a burst period that is followed by a rest period. The apparatus also includes a respiration sensor coupled to the pulse generator. The respiration sensor detects the inspiration and the expiration phases of the respiration. The pulse generator generates stimulation pulses during both the detected inspiration and expiration phases. The pulses are delivered with the output parameter adjusted to provide greater stimulation strength during the inspiration phase than during the expiration phase.Type: GrantFiled: April 30, 2010Date of Patent: June 17, 2014Assignee: Medtronic, Inc.Inventor: Avram Scheiner
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Patent number: 8751004Abstract: Methods and devices are provided for electrical stimulation of the expiratory muscles in humans or other mammals to produce cough in patients with spinal cord injuries resulting in paralysis of the expiratory muscles. An electrode, or a group of two or more electrodes (i.e. wire lead electrodes, disc electrodes, etc.) are positioned along the spinal cord, usually along the dorsal epidural surface. The electrodes can be located at different spinal cord levels and can be located in a parallel arrangement. Electrical stimulation, such as bipolar electrical stimulation, is then applied to activate the expiratory muscles and produce cough.Type: GrantFiled: August 27, 2012Date of Patent: June 10, 2014Inventor: Anthony Fortunato DiMarco
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Patent number: 8751005Abstract: A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's Hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the Hypoglossal nerve to stimulate at least one muscle of the tongue. Methods may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle. The stimulation load to maintain the position of the tongue may be shared by each muscle. The position of the patient's tongue may be controlled in order to prevent obstructive sleep apnea.Type: GrantFiled: March 19, 2013Date of Patent: June 10, 2014Assignee: Imthera Medical, Inc.Inventors: Paul M. Meadows, Marcelo G. Lima, Faisal N. Zaidi
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Patent number: 8744589Abstract: A method of stimulating a nerve of a patient. The method may include positioning a first electrode set on a first portion of the nerve, wherein the first portion of the nerve innervates a first upper airway muscle of the patient. The method may include positioning a second electrode set on a second portion of the nerve, wherein the second portion of the nerve innervates a second upper airway muscle of the patient. The method may further include alternatively delivering an electrical stimulation to the first electrode set and to the second electrode set.Type: GrantFiled: December 29, 2010Date of Patent: June 3, 2014Assignee: Cyberonics, Inc.Inventors: Stephen L. Bolea, Thomas B. Hoegh, Bruce J. Persson, Robert E. Atkinson, Scott T. Mazar
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Publication number: 20140142652Abstract: The present invention provides, among other things, apparatus and methods of use for treating a subject in need of assistance with breathing. In some embodiments the subject suffers from airflow obstruction. In some embodiments, the subject suffers from chronic obstructive pulmonary disease.Type: ApplicationFiled: January 25, 2012Publication date: May 22, 2014Applicant: APELLIS HOLDINGS, LLCInventors: Cedric Francois, Angus McLachlan
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Patent number: 8731672Abstract: A method of reducing bronchial constriction in a subject includes delivering energy to create one or more lesions on a main bronchus so as to transect pulmonary nerves sufficiently to reduce bronchial constriction in a lung of the patient distal to the main bronchus.Type: GrantFiled: June 18, 2013Date of Patent: May 20, 2014Assignee: Holaira, Inc.Inventors: Edwin J. Hlavka, Lynn Elliott
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Publication number: 20140135868Abstract: A non-invasive, removable intraoral electrical Stimulator or Pacemaker system and method is described, for electrically-stimulating and re-establishing the tone in the upper pharyngeal dilator muscle, the genioglossus and base-of-tongue muscles, for the treatment of Obstructive Sleep Apnea (OSA) in human adults and young adults. The Stimulator system consists of an intraoral Stimulator device assembly with a rechargeable battery, an external (inductive) Recharger appliance and an external hand-held (inductive) Programmer appliance. The Stimulator device assembly is inserted into the mouth by the OSA patient before sleep time and is removed when awake or during normal activity and placed in the charging cradle of the Recharger appliance for recharging the device battery. The physician uses the hand-held Programmer appliance to determine and set the patient-specific stimulation therapy parameters in the device, at the patient's initial evaluation.Type: ApplicationFiled: November 7, 2013Publication date: May 15, 2014Inventor: JACOB BASHYAM BASHYAM
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Publication number: 20140128936Abstract: A medical device for treating an airway of a patient. The medical device may include an elongate tubular member having a proximal end, a distal end, and a lumen extending therebetween. The medical device may also include a plurality of conductive elements disposed on a surface of the elongate tubular member. In some embodiments, at least one of the plurality of conductive elements may be disposed distally of another of the plurality of conductive elements. In addition, each of the plurality of conductive elements may be electrically coupled to a surface of the lumen. The medical device may also include a piston movably disposed within the lumen. The piston may include a distal portion configured to make electrical contact with one or more of the plurality of conductive elements.Type: ApplicationFiled: October 31, 2013Publication date: May 8, 2014Applicant: Boston Scientific Scimed, Inc.Inventors: Michael D. LAUFER, William WIZEMAN, Noah WEBSTER, Jerry JARRARD
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Patent number: 8718776Abstract: A device according to some embodiments of the present disclosure includes a housing configured to retain a battery, a primary antenna associated with the housing, and at least one processor in electrical communication with the battery and the primary antenna. In some embodiments, the at least one processor may be configured to cause transmission of a primary signal from the primary antenna to an implantable device during a treatment session of at least three hours in duration, wherein the primary signal is generated using power supplied by the battery and includes a pulse train, the pulse train including a plurality of modulation pulses.Type: GrantFiled: September 28, 2012Date of Patent: May 6, 2014Assignee: Nyxoah SAInventors: Adi Mashiach, Carsten Mueller
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Patent number: 8718783Abstract: A method of stimulating a hypogossal nerve including chronically implanting a nerve cuff electrode on a portion of the hypoglossal nerve. The method may further include sensing a signal corresponding to respiration and detecting expiratory onset from the sensed signal. Moreover, the method may include delivering a stimulus to the portion of the hypoglossal nerve via the nerve cuff electrode, wherein the stimulus is delivered as a function of the detected expiratory onset.Type: GrantFiled: December 15, 2011Date of Patent: May 6, 2014Assignee: Cyberonics, Inc.Inventors: Stephen L. Bolea, Thomas B. Hoegh, Bruce J. Persson, Robert E. Atkinson, Scott T. Mazar
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Patent number: 8712531Abstract: A system for providing baroreflex stimulation comprises a sensor to detect a parameter and provide a signal indicative of the parameter and a baroreflex stimulator. The baroreflex stimulator includes a driver to provide a control signal adapted to deliver a baroreflex therapy and a controller to receive the signal indicative of the parameter and modulate the control signal based on the signal indicative of the parameter to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.Type: GrantFiled: May 24, 2012Date of Patent: April 29, 2014Assignee: CVRx, Inc.Inventors: Robert S Kieval, Matthew M Burns, David J Serdar
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Patent number: 8706235Abstract: A system and method for delivering a nerve stimulation therapy determines whether a cardiac EGM signal can be sensed by a bipolar pair of electrodes selected from a number of electrodes positioned for stimulating a nerve. In response to not being able to sense a cardiac signal using the bipolar pair, stimulation of the nerve using a selected pair of the electrodes is enabled.Type: GrantFiled: July 27, 2011Date of Patent: April 22, 2014Assignee: Medtronic, Inc.Inventors: Mustafa Karamanoglu, Vincent E. Splett, Nancy J. Rakow, Linnea R. Lentz
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Patent number: 8706236Abstract: A method of conditioning a diaphragm of a patient is provided. The method can include the steps of implanting an electrode adjacent a target site in the diaphragm of the patient and operating the electrode to deliver a sufficient amount of electrical stimulation to the target site in the diaphragm of the patient to cause the diaphragm to contract.Type: GrantFiled: March 25, 2013Date of Patent: April 22, 2014Assignee: Synapse Biomedical, Inc.Inventors: Anthony R. Ignagni, Raymond P. Onders
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Publication number: 20140107727Abstract: A device according to some embodiments may include a housing configured for location external to a body of a subject. The device may also include at least one processor associated with the housing and configured to communicate with a circuit implanted in the subject within proximity to a tongue of the subject, wherein the circuit is in electrical communication with at least one electrode, receive a physiological signal from the subject via the circuit, and send a control signal to the implanted circuit in response to the physiological signal, wherein the control signal is predetermined to activate neuromuscular tissue within the tongue.Type: ApplicationFiled: September 30, 2013Publication date: April 17, 2014Inventor: Adi Mashiach
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Patent number: 8700183Abstract: A device may include an implantable circuit and at least one pair of implantable electrodes, in electrical communication with the implantable circuit. The circuit and the electrodes may configured for implantation in a subject in the vicinity of a nerve. The circuit may be configured to deliver to the electrodes an electrical signal having a current less than about 1.6 milliamps, and the electrodes may be configured to emit an electric field such that a portion of the field lines extend along a length of the nerve such that the delivery of the electrical signal of less than about 1.6 milliamps causes modulation of the nerve.Type: GrantFiled: September 28, 2012Date of Patent: April 15, 2014Assignee: Nyxoah SAInventor: Adi Mashiach
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Patent number: 8688219Abstract: Dynamic sampling of physiological parameters based on the next anticipated occurrence of a relatively periodic physiological event. Embodiments of the invention may be used to increase the battery life or effective data storage capacity of implantable medical devices while retaining or improving measurement resolution.Type: GrantFiled: July 28, 2006Date of Patent: April 1, 2014Assignee: Medronic, Inc.Inventor: Scott A. Ransom
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Patent number: 8676324Abstract: Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.Type: GrantFiled: July 15, 2011Date of Patent: March 18, 2014Assignee: Electrocore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Patent number: 8676323Abstract: Systems and methods are provided to improve respiratory function. Systems include an external electrical stimulator coupled to electrodes that stimulates diaphragm contraction and may optionally include a positive pressure mechanical ventilator. The system further includes an electrode suitable for temporary implantation. Electrical stimulation is provided to specific portions of the diaphragm, such as one hemidiaphragm preferentially over another. By preferentially contracting one hemidiaphragm, a specific portion of a lung may be expanded, such as a posterior portion. By the provision of the negative intrathoracic pressure from diaphragm contraction, greater expansion of specific portion of lung is achieved in relationship to air pressure within the lung, thereby improving compliance. Supplementation of stimulated diaphragm contraction with positive pressure driven air flow from a PPMV directs the air flow to specific portions of the lung.Type: GrantFiled: March 9, 2007Date of Patent: March 18, 2014Assignee: Synapse Biomedical, Inc.Inventors: Anthony R. Ignagni, Raymond P. Onders
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Patent number: 8676325Abstract: An adaptive airway treatment system is described for treating a dorsal displacement disorder in a horse. A pacemaker processor generates a dorsal displacement disorder treatment signal as a function of at least one therapy parameter. One or more stimulation electrodes are adapted to interface with tissue of the horse for delivering the treatment signal to continuously or intermittently stimulate soft palate tissue of the horse during an entire period of increased activity of the horse or for training prior to exercise.Type: GrantFiled: December 29, 2011Date of Patent: March 18, 2014Assignees: MED-EL Elektromedizinische Geraete GmbH, Cornell UniversityInventors: Werner Lindenthaler, Norm G. Ducharme
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Patent number: 8660647Abstract: A method for stimulating a portion of a vagus nerve of a patient to treat a pulmonary disorder is provided. At least one electrode is coupled to at least one portion of a left vagus nerve and/or a right vagus nerve of the patient. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the pulmonary disorder. The electrical signal may perform a blocking of an intrinsic neural activity on said at least one portion of the left vagus nerve and said right vagus nerve.Type: GrantFiled: July 28, 2005Date of Patent: February 25, 2014Assignee: Cyberonics, Inc.Inventors: Steven M. Parnis, Steven E. Maschino, William R. Buras, Albert W. Guzman
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Publication number: 20140039450Abstract: A method of influencing bronchoconstriction in a mammal comprising applying a stimulation in one or more regions of the brain of the mammal, and an apparatus therefore. The method and apparatus may be used to treat a respiratory disease or sleep apnea.Type: ApplicationFiled: October 6, 2011Publication date: February 6, 2014Applicant: Isis Innovation Ltd.Inventor: P. A. Handford
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Publication number: 20140039238Abstract: Techniques are provided for use with an implantable cardiac rhythm management (CRMD) system equipped to deliver neurostimulation to acupuncture sites within anterior regions of the neck, thorax or abdomen of the patient. Parameters associated with the health of the patient are detected, such as parameters indicative of arrhythmia, heart failure and hypertension.Type: ApplicationFiled: July 31, 2012Publication date: February 6, 2014Applicant: PACESETTER, INC.Inventors: Xiaoyi Min, Stuart Rosenberg, Taraneh Ghaffari Farazi, Timothy A. Fayram
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Publication number: 20140039286Abstract: Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.Type: ApplicationFiled: October 2, 2013Publication date: February 6, 2014Applicant: SIMON FRASER UNIVERSITYInventor: Joaquin Andres Hoffer
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Patent number: 8644939Abstract: A method and device for treating sleep apnea and sleep hypopnea by monitoring respiratory-related activity from the internal branch of the superior laryngeal nerve, interpreting these internal signals to detect and classify apnea events, and stimulating nerves or muscles to elicit appropriate corrective responses to adverse respiratory events.Type: GrantFiled: November 18, 2008Date of Patent: February 4, 2014Assignee: Neurostream Technologies General PartnershipInventors: Willard Wilson, Nader Kameli
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Patent number: 8644921Abstract: The present disclosure provides systems and methods for treating apnea by controlled delivery of a swallow stimulus to a subject in which apnea is detected. In the systems and method, burst electrical or mechanical stimulation to one or more swallow-related nerves and/or muscles can be timed for delivery between the expiratory phase of the respiration cycle, following detection of an apneic event in the subject.Type: GrantFiled: May 16, 2011Date of Patent: February 4, 2014Assignee: Neurostream Technologies G. P.Inventor: Willard Wilson
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Patent number: 8640711Abstract: A method for treating the lung during an acute episode of reversible chronic obstructive pulmonary disease such as an asthma attack. The method comprises transferring energy to an airway wall of an airway such that a diameter of the airway is increased. The energy may be transferred to the airway wall prior to, during or after an asthma attack. The energy may be transferred in an amount sufficient to temporarily or permanently increase the diameter of the airway. The method may be performed while the airway is open, closed or partially closed.Type: GrantFiled: December 9, 2010Date of Patent: February 4, 2014Assignee: Asthmatx, Inc.Inventors: Christopher J. Danek, Bryan E. Loomas, Thomas M. Keast, Michael D. Laufer
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Patent number: 8644957Abstract: A device according to some embodiments may include an implantable flexible carrier and a pair of electrodes located on the carrier. The electrodes may be spaced from each other by a distance greater than 3 mm, and may be configured to cause, when supplied with an electrical signal, a unidirectional electric field sufficient to modulate at least one nerve.Type: GrantFiled: September 28, 2012Date of Patent: February 4, 2014Assignee: Nyxoah SAInventor: Adi Mashiach
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Publication number: 20140031890Abstract: A device for conveying power from a location external to a subject to a location within the subject may include a flexible carrier and an adhesive on a first side of the carrier. A coil of electrically conductive material may be associated with the flexible carrier. A mechanical connector may be associated with the carrier opposite the adhesive, wherein the mechanical connector is configured to retain a housing and permit the housing to rotate relative to the flexible carrier. At least one electrical portion may be associated with the carrier in a manner permitting electrical connection to be maintained between the flexible carrier and the housing as the housing is rotated.Type: ApplicationFiled: July 26, 2013Publication date: January 30, 2014Inventors: Adi Mashiach, Tim Ruytjens