Abstract: In a method for implantation of a physically stabilized aggregate of living cells or tissue fragment is injected into a channel provided in soft tissue filled with an aqueous gel. Also discloses are methods of stabilizing such aggregates and fragments and of forming such channel in soft tissue as well as means for carrying out the methods.

Abstract: A method is provided for precision dosing of electrical stimulation of the brain. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of an electro-stimulation device including a plurality of electrodes positioned on a head of a subject. The method also includes obtaining measurements that indicate a tissue type at each voxel inside the head of the subject based on an imaging device. The method also includes determining, with a processor, a value of one or more parameters of the electro-stimulation device based on the tissue type measurements at each voxel such that the electro-stimulation device is configured to generate a value of one or more parameters of an electric field at each voxel inside the head of the subject to improve the treatment outcome of the subject.

Abstract: An implant system is provided, which includes an implant, including an implant body and an electrode disposed on the implant body; and a hollow needle, which is configured to be percutaneously advanceable into tissue of a subject. The hollow needle is shaped so as to define a lumen dimensioned to house the implant; at a distal end of the hollow needle, a distal end opening configured to facilitate passage of the implant therethrough from the lumen; and a lateral wall shaped so as to define a window therethrough to the lumen. Other embodiments are also described.

Abstract: A method for treating a patient for anxiety, depression, and insomnia. The method includes generating a stimulation conveyed to the patient for a treatment duration current via generating a carrier waveform being an alternating current having a duty cycle ratio and a current amplitude ratio being selected such that each respective integration of the current amplitude between successive time instances at which the carrier waveform alternates polarity is substantially equivalent. The method further includes generating a stimulation current from the carrier waveform via amplitude modulating the carrier waveform. The extremes of the stimulation current defining a stimulation current envelope defining first and second series of pulses. The first series of pulses occurring at a first frequency that does not substantially vary for the entire treatment duration, and the second series of pulses occurring at a second frequency that varies during the treatment duration.

Abstract: A microcurrent migraine treatment device includes an adaptive trigger circuit configured to dynamically determine a triggering threshold for applying a therapeutic microcurrent via a treatment electrode to a treatment location on a person's skin for treatment of a migraine condition.

Abstract: An example medical device includes processing circuitry configured to determine an electrode impedance value for each of one or more electrodes of a lead coupled to the medical device, identify one or more of the electrodes having electrode impedance values that are greater than electrode impedance values of other electrodes of the lead, from the identified one or more electrodes, determine a recommendation of electrodes to use for sensing a signal, and output information indicative of the recommendation.

Abstract: The present invention provides a non-drug cardio-cerebrovascular disease therapeutic apparatus. A waveform diagram of a pulse current for generating a pulse electromagnetic field includes four characteristic bands in a cycle range of 360° and reciprocates circularly: an abrupt-rising band T1 where a current intensity I(t) abruptly rises, wherein a highest value thereof is slightly lower than a maximum value Imax of an output current; a first slow-rising band T2 where the current intensity I(t) slowly rises to the maximum value Imax; an abrupt-decreasing band T3 where the current intensity I(t) abruptly decreases, wherein a minimum value Imin thereof is slightly higher than a minimum value (Imin) of the output current; and a slow-decreasing band T4 where the current intensity I(t) slowly decreases to the minimum value (Imin).

Abstract: The present invention relates to a system for use in the treatment or prevention of disease or symptoms thereof, the system comprising: at least one object, wherein the object is configured for being positioned in or adjacent to the pituitary gland or the pituitary stalk of a subject; and a device configured to generate at least one intermittent stimulating signal in the object, wherein the signal subsequently activates a release of biologically active agents.

Abstract: An electrode management solution for neuromonitoring applications such as electroencephalography (EEG) procedures provides for the verification of the locations and connections of electrodes. The brain is modeled as a volume conductor and an expected attenuated signal generated by an electrical signal present in the form of an electrical dipole at any other point in the brain is calculated. A known signal is connected between electrodes at ‘presumed’ locations. This action generates a defined electrical field which can be measured between any of the other electrode locations. The amplitude and phase of the measured signals are a function of the input signal, the volume conductor, and the geometric relations of the two electrodes. By comparing the expected values with the measured values, the relation between the electrodes is verified.

Abstract: A system includes a sensing assembly configured to be disposed on a mastoid of a user. The sensing assembly includes a housing, a first sensor disposed in the housing and configured to measure a first phybrata signal from the user, and a second sensor disposed in the housing and configured to measure a second phybrata signal from the user, the second phybrata signal different from the first phybrata signal. A controller is in communication with the sensing assembly. The controller is configured to: receive a first phybrata data from the sensing assembly, the first phybrata data including information obtained from the first phybrata signal and the second phybrata signal. The controller is configured to determine a phybrata parameter associated with the user based on the first phybrata data, and determine a phybrata signature associated with the user based on the phybrata parameter.

Abstract: Provided are systems, methods, and devices for providing mediation of a traumatic brain injury. Systems may include an interface, processing devices, and a controller. The interface is configured to obtain measurements from a brain of a user with a traumatic brain injury. A first processing device is configured to generate multiple brain state parameters characterizing one or more features of a brain state of the user. A second processing device is configured to generate models of the brain of the user based on the plurality of brain state parameters and the plurality of measurements, and determine, using the models and training data comprising one or more mediation data points, a mediation procedure for reducing one or more symptoms of the traumatic brain injury. The mediation procedure is provided to one or more entities, and one or more control signals are generated by the controller based on the mediation procedure.

Abstract: A method of applying tumor treating fields to a region of interest of a subject's body corresponding to a tumor, the method including: alternately applying to the region of interest a first electric field between a first pair of locations of the subject's body and a second electric field between a second pair of locations of the subject's body; detecting a change in the region of interest of the subject's body; ceasing applying the first and second electric fields; selecting, based on the detected change, a third pair of locations of the subject's body and a fourth pair of locations of the subject's body, the third and fourth pairs of locations being different than the first and second pairs of locations; and alternately applying to the region of interest a third electric field between the third pair of locations and a fourth electric field between the fourth pair of locations.

Abstract: Systems and techniques for wireless implantable devices, for example implantable biomedical devices employed for biomodulation. Some embodiments include a biomodulation system including a non-implantable assembly including a source for wireless power transfer and a data communications system, an implantable assembly including a power management module configured to continuously generate one or more operating voltage for the implantable assembly using wireless power transfer from the non-implantable assembly, a control module operably connected to at least one communication channel and at least one stimulation output, the control module including a processor unit to process information sensed via the at least one communication channel and, upon determining a condition exists, to generate an output to trigger the generation of a stimulus.

Abstract: Various examples are provided for simultaneous bilateral brain stimulation. In one example, a method includes applying a first stimulation signal at a first frequency through a feature-side implanted neural stimulator (INS) on a first side of a brain, applying a second stimulation signal at a second frequency through a non-feature-side INS on a second side of the brain, and detecting a stimulation interference signal with the non-feature-side INS. The first stimulation signal can be a pulsed signal and the second simulation signal can be a continuous signal at a low stimulation voltage, and the stimulation interference signal at an interference frequency based upon the first and second frequencies. In another example, a neural stimulation system including a feature-side neural stimulator and a non-feature-side neural stimulator implanted on first and second sides of the brain and neural stimulation circuitry coupled to the neural stimulators.

Abstract: Provided is an apparatus for evaluating and improving responses, and a method and a computer readable recording medium thereof. The apparatus for evaluating responses according to the present disclosure obtains cluster classifying information for training responses, and based on distribution of clusters to which test responses output from the dialogue generation model are classified, evaluate semantic diversity of the responses output from the dialogue generation model.

Abstract: Novel auricular health monitoring systems, preferably including one or more of the following: auricular electroencephalogram (EEG), electrooculogram (EOG), electrocardiogram (ECG) and ear-canal pulse oximeter, which may be useful in health monitoring or in brain-computer interface. The EEG electrodes, EOG electrodes, ECG electrodes, light generator and light detecting sensor may be housed on a surface of an earbud-style structure or other in-ear structures made of flexible elastic and adaptable material such that these pre-mounted EEG electrodes, EOG electrodes, ECG electrodes and the pulse oximeter will be naturally and snugly contacting the skin of the wearer's external ear canal. A processing unit may be configured to analyze data from EEG system, EOG system, ECG system and ear-canal pulse oximeter to assess the wearer's health profile. These wearable monitoring systems are suitable for easy self-installation or self-removal and daily ambulatory use.

Abstract: Electrical stimulation systems and methods for operation of the electrical stimulation system are described. The method includes directing electrical stimulation through the electrodes of the lead and monitoring movements of a hand positioned over an implantation site of an implantable control module of the electrical stimulation system using an accelerometer coupled to a processor of the implantable control module. Another method includes detecting, by a sensor, a plurality of taps of a body region of a patient over an implantation site of the implantable control module, identifying, by the processor of the implantable control module, an indicator, trigger, or marker based on the detected tapping, and performing an activity corresponding to the identified indicator, trigger, or marker.

Abstract: In one embodiment, the present disclosure is directed to a method for providing a neural stimulation therapy to treat chronic pain of a patient. The method comprises: recording, using a neural sensing system, neural activity of the patient at one or more sites within the nervous system of the patient related to the chronic pain of the patient, modifying a computational neural modeling system to model the sensed neural activity of the patient; computing a respective neural response of the patient for each of a plurality of different temporal stimulation patterns using the modified computational neural modeling system; selecting, based on the respective neural responses, one of the plurality of temporal stimulation patterns; and programming an implantable stimulation system to provide the selected one of the plurality of temporal stimulation patterns to the patient to treat the chronic pain of the patient.

Abstract: A method for selective activation of central thalamus fibers in a subject is disclosed. The method involves providing one or more electrodes each with one or more contacts. The one or more electrodes are positioned in the subject's central thalamus fibers. An electrical stimulus is applied to the positioned one or more electrodes to selectively activate the central thalamus fibers of the subject. The positioning and applying are carried out to maximize central lateral nucleus and medial dorsal tegmental tract fiber pathway activation in the subject and to minimize central median parafascicularis fiber pathway activation in the subject. Methods, devices, and computer readable media for surgical planning involving selective activation of central thalamus fibers in a subject are also disclosed.

Abstract: Amyloid fibers-based electrodes and apparatuses comprising the same. Additionally, methods for manufacturing amyloid fibers-based electrodes.

Abstract: The patent application describes an adaptable neuromodulation device for transcranial electrical brain stimulation. The system can generate complex poly-modulated waveforms by combining multiple pulse parameters in a randomized manner across dimensions like amplitude, frequency, phase, timing, and polarity. It leverages both digital and analog modulation techniques for waveform versatility. The device features pathway optimization algorithms that tune stimulation using neural feedback data to target specific brain region shapes with greater precision. It also enables closed-loop operation for responsiveness to physiological changes. The application details the mathematical and computational foundations, spanning graph theory to generate digital twins. It highlights applications from cognitive enhancement to seizure control. Overall, the innovation promises versatility and precision in non-invasive neuromodulation through adaptable, optimized waveforms grounded in sophisticated modeling.

Abstract: A method for assessment of brain signals of a patient includes determining, by one or more processors, a cluster of neural data occurring at a brain of the patient and outputting, by the one or more processors, a request for a user to provide patient state information for the cluster of the neural data in response to determining that the cluster of the neural data is occurring at the brain of the patient. The method further includes associating, by the one or more processors, the patient state information with the cluster of the neural data to generate patient assessment information and outputting, by the one or more processors, the patient assessment information.

Abstract: A method for estimating an arrangement of electrodes obtains detection signals when an initial electrode array having a sufficient number of electrodes for detection of excitation wave arranged and arrayed in a plane is attached to biological tissue. The method uses a plurality of input data based on detection signals obtained in a plurality of second electrode arrays generated by eliminating a predetermined number of electrodes at random from the initial electrode array, and uses an image of excitation wave in a process of obtaining the detection signals by using the initial electrode array, as teacher data, obtaining a learned model by deep learning. The method selects a second electrode array corresponding to an analysis image that is best matched with the image of the teacher data, among a plurality of analysis images obtained by applying the plurality of input data to the learned model, as a selective electrode array.

Abstract: We report a method of determining an occurrence of an epileptic convulsive seizure in a patient, comprising: receiving body data from a patient during a first time period, determining a work level relating to said first time period at least based partially upon said body data; determining whether said work level exceeds an extreme work level threshold; performing a responsive action, in response to a determination that said work level exceeds said extreme work level threshold. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

Abstract: A system for optimizing DBS parameters for a subject includes automatically performing actions via a processor. The actions include obtaining functional MRI data of a brain of the subject acquired utilizing an MRI system during DBS of the brain utilizing a first set of DBS parameters. The actions include generating functional MRI response maps from the functional MRI data. The actions include extracting, utilizing an unsupervised autoencoder-based neural network, features from the functional MRI response maps. The actions include determining, utilizing a deep learning-based DBS parameter classification model, whether the first set of DBS parameters are optimal DBS parameters for the subject based on the features. The actions include, when the first set of DBS parameters are not the optimal DBS parameters, predicting, utilizing a deep learning-based DBS parameter prediction model, a second set of DBS parameters that are the optimal DBS parameters for the subject based on the features.

Abstract: The present invention pertains to a medical treatment device for stimulating neurons of a patient to suppress a pathologically synchronous activity, the device comprises at least three non-invasive stimulating units for generating stimuli to a patient's body, and a control unit for selectively and intermittently actuating the stimulating units in a sequence of actuating periods. The control unit is configured to, across the sequence of actuating periods, variedly determine for each actuating period a number n of stimulating units to be simultaneously actuated during the respective actuating period.

Abstract: A method for minimally invasive deep brain simulation (DBS) involves obtaining a target location for the DBS, obtaining an anatomical model, and simulatively determining, for a set of antennas endocranially implanted at first positions and emitting electromagnetic waves differing by a frequency offset, a first envelope signal at the target location, using the anatomical model. The first envelope signal resulting from interference of the electromagnetic waves at the target location has an envelope signal frequency corresponding to the frequency offset.

Abstract: A method or system for generating a clinical effects map for electrical stimulation includes receiving stimulation parameters and at least one clinical response for each of a plurality of stimulation instances; for each of the stimulation instances, determining a radius of a stimulation field according to the stimulation parameters for the stimulation instance; generating the clinical effects map using the at least one clinical response and the stimulation parameters for each of the stimulation instances, wherein, for each of the stimulation instances, the at least one clinical response for the stimulation instance is assigned to the radius of the stimulation field determined for the stimulation instance; and displaying the clinical effects map.

Abstract: Conventional devices deliver a degree of electrical charge into biological tissues; to satisfy regulatory and safety concerns, measures are taken to maintain a zero-charge residual at the stimulation site. Disclosed herein is a method of controlling electrical energy provided by a stimulation device to one or stimulation electrodes comprised in the device, the device including: a first stimulation electrode; a pulse energy controller for transferring electrical energy as one or more electrical stimulation pulses to the first stimulation electrode; the pulse energy controller further including two or more stimulation energy supplies for each supplying electrical energy substantially concurrently to the first stimulation electrode as a first pulse; and each supplying electrical energy separately to the first stimulation electrode as a second pulse.

Abstract: An electrode can comprise carbon black and one of polydimethylsiloxane (PDMS) or PVA, wherein the carbon black has a weight of between 10% and 50% of a weight of the PDMS or PVA. The electrode can be suitable for bioelectronics. A pattern of hydrogel can be deposited on the electrode for providing adhesion to a subject. The electrode can be used in wound treatment and/or monitoring devices or in various other bioelectronics applications.

Abstract: A method of providing a channel in nervous tissue filled with an aqueous gel for implantation of a microelectrode or other medical device lacking sufficient physical stability for direct implantation by insertion, comprises providing an apparatus comprising an oblong rigid pin covered by a dry gel forming agent; locating a target in the tissue; defining a straight insertion path a desired tissue insertion point and the target; aligning the pin with its end foremost with the insertion path; inserting the pin into the tissue to a position near or at the target; allowing sufficient time to pass for a gel to be formed around the pin, withdrawing the pin. Also disclosed is a corresponding channel; a method of implantation of a microelectrode or microprobe into nervous tissue via the channel; a corresponding method of implantation of living cells; a corresponding apparatus for forming the channel.

Abstract: Therapy systems with quantified biomarker targeting, including for epilepsy treatment, and associated systems and methods, are disclosed. A representative computer-based method for establishing epilepsy treatment parameters for a patient includes receiving multiple indications of interictal EEG biomarkers over a period of time and processing the multiple indications to produce a processed biomarker. The processed biomarker is then used to identify at least one target location at the patient's brain to receive an electrical therapy signal to reduce or eliminate epileptic activity in the patient, and at least one additional signal delivery parameter in accordance with which the electrical therapy signal is to be delivered.

Abstract: A method for providing electrical stimulation to a user as a user performs a set of tasks during a time window, the method comprising: providing an electrical stimulation treatment, characterized by a stimulation parameter and a set of portions, to a brain region of the user in association with the time window; for each task of the set of tasks: receiving a signal stream characterizing a neurological state of the user; from the signal stream, identifying a neurological signature characterizing the neurological state associated with the task; and modulating the electrical stimulation treatment provided to the brain region of the user based upon the neurological signature, wherein modulating comprises delivering a portion of the set of portions of the electrical stimulation treatment to the brain region of the user, while maintaining an aggregate amount of the stimulation parameter of the treatment provided during the time window below a maximum limit.

Abstract: An imaging method may include: emitting a first laser to a target body and receiving a first photoacoustic signal returned from the target body; determining a first photoacoustic image of the target body according to the first photoacoustic signal; emitting a second laser to the target body and receiving a second photoacoustic signal returned from the target body, wherein a wavelength of the second laser is different from that of the first laser; determining a second photoacoustic image of the target body according to the second photoacoustic signal; and determining a blood oxygen image of the target body according to the first photoacoustic image and the second photoacoustic image, wherein the blood oxygen image comprises parameters relate to blood vessels of a target tissue and parameters relate to blood vessels within a preset range at a periphery of the target tissue in the target body.

Abstract: Implanted pulse generators with reduced power consumption via signal strength-duration characteristics, and associated systems and methods are disclosed. A representative method for treating a patient in accordance with the disclosed technology includes receiving an input corresponding to an available voltage for an implanted medical device and identifying a signal delivery parameter value of an electrical signal based on a correlation between values of the signal delivery parameter and signal deliver amplitudes. The signal deliver parameter can include at least one of pulse width or duty cycle. The method can further include delivering an electrical therapy signal to the patient at the identified signal delivery parameter value using a voltage within a margin of the available voltage.

Abstract: Provided herein are apparatuses, systems and methods for non-invasively assessing synaptic dysfunction in a patient with Alzheimer's Disease. Transcranial magnetic stimulation (TMS) is applied to at least one brain region of the patient. A plurality of TMS evoked potentials generated in response to the TMS applied to the at least one brain region of the patient is recorded with a plurality of electroencephalography (EEG) electrodes. At least one characteristic of the plurality of TMS evoked potentials is analyzed to assess synaptic dysfunction in the patient. An indication of the synaptic dysfunction assessment of the patient is output.

Abstract: The disclosure relates to a brain stimulation system, comprising: a) a computer program product, comprising program code which provides an operation control system, or b) an electronic control unit with a program code, wherein the program code provides an operation control system, wherein the operation control system is configured to control a brain training and/or stimulation session for a brain, and comprises a plurality of control system functionalities, the control system functionalities comprising: a stimulation functionality which is configured to cause the electronic control unit to issue a stimulation command to an electrical brain stimulation device to cause the device to perform a procedure; and a presentation functionality which is configured to cause the electronic control unit to issue a presentation command in order to present a task to be performed by a user on a user interface, wherein preferably the stimulation functionality and the presentation functionality are linked or linkable.

Abstract: A system for electrically stimulating a user comprising: a first housing portion defining an array of openings; an array of permeable bodies with portions exposed through the array of openings and wetted with a solution that facilitates electrical coupling between the system and a body region of the user, wherein each permeable body has a cavity at a proximal portion and a distal portion and is configured to transmit the solution to the body region of the user; a substrate region defining an array of protrusions configured to support the array of permeable bodies and composed of a conductive polymer; and a set of conductors in communication with the substrate region and including a first conductor that provides a first subset of the array of permeable bodies with a first polarity and a second conductor that provides a second subset of the array of permeable bodies with a second polarity.

Abstract: Simulating interaction with an object represented in a virtual environment is disclosed. A system includes one or more circuits configured to receive an indicator of a sensed touch in a virtual environment and to determine, based on the indicator, an area of the sensed touch. The one or more circuits are further configured to generate a simulated touch by applying a field to one or more touch simulators, the field actuating the one or more touch simulators by linearly displacing an element of the one or more touch simulators. In implementations, the touch simulators are actuated based on data describing textures and weights of the object represented in the virtual environment.

Abstract: Examples of the presently disclosed technology provide new systems and methods for performing direct targeting for DBS procedures (and other related procedures) using a single pre-operative scan of a patient's brain. Examples can achieve this single-scan direct targeting by leveraging mesh vertex-based correspondences between patient-specific 3D mesh brain structure representations across prospective and historical DBS procedures. Examples can leverage such correspondences to accurately predict DBS lead placement coordinates for a prospective DBS procedure based on historical DBS lead placement coordinates from the historical DBS procedures. Accordingly, a clinician performing the prospective DBS procedure can utilize the predicted DBS lead placement coordinates for surgical planning purposes.

Abstract: Methods and systems for providing stimulation therapy are disclosed. Embodiments of the system include an implantable stimulator and an external controller configured to control the implantable stimulator. A clinician can prescribe a set amount of stimulation therapy to a patient. The external controller is programmed with the prescription. As the patient uses the external controller and the stimulator device the external controller tracks the amount of stimulation the patient uses. Once the patient has used all of the prescribed therapy the patient may return to the clinician for a follow-up appointment.

Abstract: The present method and system provides a neuromodulation therapy including receiving a plurality of input data relating to a patient, the input data including brain value measurements. The method and system includes analyzing the input data in reference to reference data generated based on machine learning operations associated with existing patient data and reference database data. Based thereon, the method and system includes electronically determining, a brain malady and a severity value for the patient and electronically generating a treatment protocol for the patient, the treatment protocol includes transcranial stimulation parameters. Therein, the method and system includes applying a transcranial stimulation using the transcranial stimulation parameters based on the treatment protocol.

Abstract: A method and system for assessment of cognitive function of an individual. The method includes having an individual execute a standardized cognitive task, followed by a brain perturbation which either excites or suppresses cognitive ability. The individual executes at least one further standardized cognitive task after the brain perturbation. Neuroimaging can be used concurrently while the individual is executing each of the tasks to obtain additional data to supplement the task scores. The post perturbation scores are compared against the pre-perturbation score to provide a standardized metric which can then be compared against individuals of the same gender and approximate age. These results can help predict and diagnose various brain diseases. A fitted helmet with integrated neuroimaging sensors, and with preset cutouts for receiving a TMS coil, facilitates positioning and orientation of the coil proximate the motor cortex and the dorsolateral prefrontal cortex for the above methods.

Abstract: An example method of delivering electrical stimulation includes obtaining, by an implantable medical device (IMD) connected to a lead carrying a plurality of electrodes, one or more stimulation parameters; and delivering, by the IMD and based on the one or more stimulation parameters, electrical stimulation therapy via the plurality of electrodes, wherein delivering the electrical stimulation therapy comprises scanning delivery of the electrical stimulation therapy through different pairs of electrodes of the plurality of electrodes.

Abstract: Disclosed are methods of altering the electric impedance to an alternating electric field in a target site of a subject, comprising introducing a nanoparticle to a target site in the subject; and applying an alternating electric field to the target site of the subject, wherein the electric impedance in the target site of the subject to the alternating current is altered. Disclosed are methods for improving transport of a nanoparticle across a cell membrane of a cell, the method comprising applying an alternating electric field to the cell for a period of time, wherein application of the alternating electric field increases permeability of the cell membrane; and introducing the nanoparticle to the cell, wherein the increased permeability of the cell membrane enables the nanoparticle to cross the cell membrane.

Abstract: A method of transplanting a desired emotional state from a donor to a recipient, comprising determining an emotional state of the donor, recording neural correlates of the emotional state of the donor who is in the desired emotional state; analyzing neural correlates of the emotional state of the donor to decode at least one of a temporal and a spatial pattern corresponding to the desirable emotional state; converting said at least one of a temporal and a spatial pattern corresponding to the desirable emotional state into a neurostimulation pattern; storing the neurostimulation pattern in the nonvolatile memory; retrieving the neurostimulation pattern from the nonvolatile memory; stimulating the recipient's brain with at least one stimulus modulated with the neurostimulation pattern to induce the desired emotional state in the recipient.

Abstract: A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.

Abstract: Systems and methods for stimulating the sensory cortex of an individual by obtaining a neuronal stimulation signal adapted to provide a movement cue for the individual and transmitting the neuronal stimulation signal to an electric contact of a neuronal stimulation electrode that is already implanted into the brain of the individual for a purpose different from providing the movement cue. Proprioceptive information is communicated to the individual by obtaining information about the body posture of the individual and applying a neuronal stimulation signal to an afferent axon targeting a sensory neuron in the cortex of the individual. The neuronal stimulation signal is determined based on the obtained body posture information and corresponds to the proprioceptive information. A first neuronal stimulation signal providing the movement cue and a second neuronal stimulation signal providing the proprioceptive information may be applied together to the cortex of the individual.

Abstract: An electrical stimulation device for modulating a blood-brain barrier (BBB) of a subject includes at least one electrode configured to delivery electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject, and a control unit in communication with the at least one electrode. The control unit generates a first electrical stimulation signal to the at least one electrode to apply a first electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject thereby increasing porosity of the BBB from an initial porosity to an increased porosity, and generate, after said first electrical stimulation signal, a second electrical stimulation signal to the at least one electrode to apply a second electrical stimulation to the subject to stimulate the SPG of the subject thereby decreasing porosity of the BBB from the increased porosity to a decreased porosity that is less than the increased porosity.

Abstract: Optimizing and/or personalizing activities to a user through artificial intelligence and/or virtual reality.