Abstract: A method of rapid frequency cycling during electrical stimulation according to an embodiment may include determining, by a controller of an electrical stimulation system, a plurality of frequency band groupings of discrete frequency bands of an electrical stimulation signal having a frequency range, wherein each frequency band grouping includes at least one discrete frequency band, wherein a corresponding current or voltage amplitude of the electrical stimulation signal is independently tuned within each discrete frequency band based on feedback received from a patient, determining, by the controller, a random sequence of the frequency band groupings of the plurality of frequency band groupings, generating, by at least one signal generator controlled by the controller, the electrical stimulation signal according to the determined random sequence of the frequency band groupings, and delivering the generated electrical stimulation signal through an electrode array to the patient to provide therapy to the patien

Abstract: A system includes processing circuitry configured to determine, for each respective electrode of a plurality of electrodes, a score based on a ratio of an electrical efficiency for the respective electrode to a therapeutic window for the respective electrodes. The processing circuitry is further configured to determine, based on the score of each respective electrode, a ranking of the plurality of electrodes, and to select, based on the ranking, a subset of the plurality of electrodes for delivery of electrical stimulation therapy.

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

Abstract: A cured electrode comprising a mixture comprising conductive elements and a carrier which, upon injection into a body, cures from a liquid phase at a first time to a biocompatible solid phase at a second time at or on a target tissue within the body. The cured electrode is capable of being molded around contours of the target tissue so that, after curing, the cured electrode retains the contours of the target tissue. The cured electrode is capable of conducting electricity at a resistance of less than 10 ohm meters in the liquid or the solid phases. Carrier materials include hydgrogel, silicone, bone cement, cyanoacrylate, dental resin and a fibrin mix. The carrier material may also be used to anchor the cured electrode and provide great stability.

Abstract: Electrostimulation systems and methods are contemplated in which a high current level, charge balanced alternating current electrical signal is generated for delivery to the frontal cortex region of a patient's brain. By stimulating this region of the brain with a charged balanced stimulation current with a stimulation current envelope defining one or more series of pulses at particular frequencies and durations designed to evoke metabolic response in the neurons, significant improvements in efficacy and reductions in patient discomfort may be achieved relative to earlier methods of transcranial electrical stimulation, especially those in which result in a resultant rectified direct current component being administered to the patient.

Abstract: In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes. The parameters may be defined based on a first plurality of electrical signals sensed at a plurality of different positions within the brain of the patient when electrical stimulation is not delivered at each of the positions and a second plurality of electrical signals sensed at each of the plurality of different positions within the brain of the patient in response to electrical stimulation delivered at each of the positions at a plurality of different intensities.

Abstract: A system for controlling delivery of electrical stimulation to a subject. The system comprises a control device configured to send stimulation instructions to an electrical stimulation generator to cause the electrical stimulation generator to deliver transcranial electrical stimulation to one or more electrodes arranged to be positioned in proximity to a targeted region of the brain of the subject. The stimulation instructions comprise stimulation parameter value(s). The control device is configured to receive sensor data from optical sensor(s) arranged to be positioned in proximity to the targeted region and transmit updated stimulation instructions comprising updated simulation parameter value(s) to the electrical stimulation generator to cause the electrical stimulation generator to modify characteristic(s) of the stimulation. The system is configured to analyse the sensor data to determine an activity measure and determine updated stimulation parameter value(s) based on the determined activity measure.

Abstract: The present application discloses a cerebral perfusion state classification apparatus and method, a device, and a storage medium. The method includes: acquiring, by a transceiving module, cervical blood flow data from an ultrasound data collecting device; determining, by a processor, cerebral perfusion data corresponding to the cervical blood flow data based on the cervical blood flow data and a mapping relationship between the cervical blood flow data and the cerebral perfusion data, and classifying cerebral perfusion states of a plurality of brain regions based on blood perfusion characteristics of the plurality of brain regions in the cerebral perfusion data.

Abstract: An illustrative system includes a behind-the-ear (BTE) sound processor configured to be worn by a patient behind an ear of the patient. The BTE sound processor is configured to direct a cochlear implant implanted within the patient to apply electrical stimulation to the patient. The system further includes a conductive contact configured to detect a signal representative of an evoked response generated by a brain of the patient. The conductive contact is integrated with the BTE sound processor so as to be located between the BTE sound processor and an external surface of a head of the patient while the BTE sound processor is worn by the patient behind the ear of the patient. Corresponding systems and methods are also disclosed.

Abstract: Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.

Abstract: Disclosed are devices, systems and methods for non-invasive neuromodulation system for prompt treatment of cerebral and/or ocular strokes caused by acute dysregulated reduced cerebral blood flow (CBF) and/or ocular blood flow (OBF) by up regulation of trigemino-vascular system (TVS), and trigeminal autonomic brain reflexes (TABRs) through stimulation of ophthalmic nerve. Additionally or alternatively, the subject's sympathetic nervous system (SNS) is down regulated centrally by intravenous administration of pharmacological dose of ascorbic acid. The site of stimulation of ophthalmic nerve includes but not limited to nasal vestibule, nasal bridge, and forehead and upper eyelid. In some embodiments, the devices are handheld, portable with nose supported, having one or more intra-nasal or extra-nasal application heads. The signal can include vibration, chemical, ultrasonic, optical, electrical, hybrid electro-optical or combination of two or more of these types of stimuli.

Abstract: The present disclosure provides a method and system for treating affective disorders such as depression and/or anxiety and/or related disorders through neuromodulatory intervention that includes brain targets within the orbitofrontal cortex (OFC). This method includes the application of electrical stimulation through an electrical signal generator device where the distal end of the device comprises at least one stimulating electrode in contact with the OFC. The treatment system includes patient selection, implantation of at least one stimulating electrode in contact with the OFC, acute or chronic electrical stimulation of the OFC, and evaluation of the effects of stimulation on clinical symptoms and status.

Abstract: An automatic noise signal interval detection method and device are provided, and the method includes receiving input data and generating initial data in a time-frequency domain, calculating power for each epoch for each channel of the initial data, generating a power graph for a specific frequency region of each channel based on the power for each epoch, generating a baseline based on an average of each channel value on the power graph, and determining, as a noise signal interval, an interval exceeding a predetermined threshold based on the baseline on the power graph.

Abstract: A medical delivery system including a carrier and a lead delivery device. The carrier defines a carrier body configured to engage a stereotactic system (or a similar pointing device with or without navigation/robotic assistance). The carrier defines a carrier channel configured to engage the lead delivery device and impart a torque to a portion of the lead delivery device. The lead delivery device and carrier are configured to cause the imparted torque to cause a cannula of the lead delivery device to rotate about a longitudinal axis of the lead delivery device. The cannula is configured to cause a rotation of an implantable lead within the cannula when the cannula is caused to rotate. The cannula is configured to translate substantially parallel to the longitudinal axis relative to the implantable lead.

Abstract: An invention and method that generate dynamical shaped voltage-gradient geometries through a plurality of dual-modal electrode-contacts placed around the biological tissue in vivo. The geometry of the voltage gradient is optimized through a feedback mechanism from the plurality of dual-modal electrode-contacts that can record electric and magnetic field potentials in the biological tissue. A control controls the waveform signal between sets of electrode-contacts to generate dynamically shaped voltage gradients to modulate a specific set of properties in the biological tissue. A method of analysis for the recorded electric and magnetic field potentials is purposed to optimize the shape of the voltage-gradient geometry through modulation of the waveform signal that is sent through the dual-modal electrode-contacts.

Abstract: A system for delivering electrical pulse stimulation to a subject includes a remote control device configured to at least intermittently transmit temporal pulse pattern programming and a stimulation device comprising a control interface, at least one electrode in electrical communication with the control interface, and an input device in at least intermittent communication with the remote control device to receive the temporal pulse pattern programming. The stimulation device is configured to deliver electrical pulse stimulation to a subject via the at least one electrode according to the temporal pulse pattern programming.

Abstract: Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

Abstract: A stimulation device includes an adaptor component. The adaptor component couples a percutaneous lead to the stimulation device. The stimulation device may apply a stimulation signal to target tissue via the adaptor. A surgeon may place the stimulation device in a container and the adaptor component may be disposed outside of the container. Methods describe prolonged stimulation of target tissue via a stimulation device. The prolonged stimulation may be applied during and after a surgical procedure.

Abstract: Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.

Abstract: The present disclosure relates to systems and methods for accessing a data structure including a subject identifier identifying a subject and a subject connectivity value derived from at least one of a scan or test provided to the subject, the subject connectivity value representing a magnitude of a connection associated with at least one sub-processing region of a nervous system of the subject; comparing the subject connectivity value to a connectivity threshold value to determine a classification of the subject; determining that the subject connectivity value exceeds the connectivity threshold value, storing in the data structure, an association between the subject identifier and a first classification value corresponding to a first classification or determining that the subject connectivity value is less than the connectivity threshold value, and storing in the data structure, an association between the subject identifier and a second classification value corresponding to a second classification.

Abstract: A method and apparatus for transdermally providing electrical current to a region of a user's head at high impedance conditions, while maintaining low voltage levels.

Abstract: Systems and methods are disclosed related to using acoustic waves to detect neural activity in a brain and/or localize the neural activity in the brain. Sensors positioned outside of a skull encasing the brain can detect acoustic waves associated with the neural activity in the brain. From output signals of the sensors, a particular type of neural activity (e.g., a seizure) can be detected. A location of the neural activity can be determined based on outputs of the sensors. In some embodiments, the ultrasound energy can be applied to the location of the neural activity in response to detecting the neural activity.

Abstract: A system for treating obstructive sleep apnea (OSA) is described. The system may include a device having a size and shape selected to couple externally to a patient near a jaw of the patient. The device may be configured to receive at least one of a needle or an introducer for insertion into a tongue of the patient for lead placement of a lead for OSA treatment, and guide at least a portion of the at least one of the needle or introducer for insertion into the tongue of the patient.

Abstract: A system and method for finding a Pareto-optimal solution for automated detection, warning, and abatement of a medical condition based on a cost of event intervention in a patient is disclosed. The method includes acquiring at least one biological signal from the patient via at least one sensor of a medical device, detecting an abnormal biological event based on changes in the biological signal, and delivering at least one of a therapy and a warning. The method includes logging a set of parameters including at least one of a detection parameter, a therapy parameter, and a therapy modality. The method includes identifying an optimal set of parameters that yield a Pareto-optimal cost of event intervention by iteratively determining at least one metric over a time window, determining the cost of event intervention, and modifying at least one parameter, until the cost of event intervention meets an acceptability criteria.

Abstract: An example method is performed by a computing device executing instructions stored in data storage, and includes receiving physiologic monitoring data from a plurality of sensors coupled to a patient, receiving information indicating a measurement of patient motion during the patient care event, determining whether the measurement of patient motion is above a threshold, based on determining whether the measurement of patient motion is above the threshold, generating, for the physiologic monitoring data, a respective quality indicator, analyzing, by the computing device, (i) a combination of the physiologic monitoring data from the plurality of sensors and (ii) the respective quality indicator for the physiologic monitoring data to generate a response dependent upon the combination of the physiologic monitoring data as weighted by the respective quality indicator, and based on analyzing, outputting caregiver feedback by the computing device according to the response.

Abstract: The provided systems, methods and devices describe lightweight, wireless tissue monitoring devices that are capable of establishing conformal contact due to the flexibility or bendability of the device. The described systems and devices are useful, for example, for skin-mounted intraoperative monitoring of nerve-muscle activity. The present systems and methods are versatile and may be used for a variety of tissues (e.g. skin, organs, muscles, nerves, etc.) to measure a variety of different parameters (e.g. electric signals, electric potentials, electromyography, movement, vibration, acoustic signals, response to various stimuli, etc.).

Abstract: Systems and techniques are disclosed to adjust programming of an implantable electrical neurostimulation device for treating chronic pain of a human subject, through the use of a dynamic model adapted to identify pain treatment parameters for a human patient and determine a best device operational program to implement the pain treatment parameters to address the chronic pain condition. In an example, the system to adjust programming of the neurostimulation device performs operations that: obtain data related to a state of pain of the human subject; identify pain treatment parameters using a dynamic model adapted to evaluate the pain treatment parameters in the human subject over a time period, based on the data related to the state of pain; and select a neurostimulation program for the neurostimulation device, corresponding to at least a portion of the identified pain treatment parameters.

Abstract: Provided is a stimulation simulation method, server and, computer program using a brain model of a brain lesion patient. The stimulation simulation method using a brain model of a brain lesion patient according to various embodiments of the present invention is a stimulation simulation method using a brain model of a brain lesion patient performed by a computing device, the method includes: collecting brain images of the brain lesion patient; generating the brain model for the brain lesion patient by using the collected brain images; and simulating stimulation to the brain of the brain lesion patient by using the generated brain model.

Abstract: Provided are systems, methods, and devices for intracranial measurement, stimulation, and generation of brain state models. Systems include a plurality of intracranial electrodes configured to be coupled to a brain of a user. Systems further include an interface configured to obtain measurements from the plurality of intracranial electrodes. Systems include a first processing device including one or more processors configured to generate a plurality of brain state parameters characterizing one or more features of at least one brain state of the user, and a second processing device including one or more processors configured to generate at least one model of the brain of the user based, at least in part, on the plurality of brain state parameters and the measurements. Systems include a controller including one or more processors configured to generate a control signal based on the plurality of brain state parameters and the at least one model.

Abstract: A method of providing therapy to a patient according to one embodiment includes partitioning a frequency range into a plurality of discrete frequency bands with each having a corresponding bandwidth, generating a composite electrical signal based on a plurality of periodic signals, wherein each periodic signal has a frequency within a corresponding frequency band of the plurality of discrete frequency bands, delivering the composite electrical signal through one or more electrodes to the patient to target at least one of neural tissue or non-neural tissue of the patient, adjusting an amplitude of one or more of a voltage or a current of the composite electrical signal within a selected frequency band of the plurality of discrete frequency bands to generate an adjusted signal based on feedback received from the patient, and delivering the adjusted electrical signal through the one or more electrodes to provide therapy to the patient.

Abstract: Aspects describe capturing the dynamic movement of one or more leaders and generating stimulus signals in real time for one or more followers to perform substantially the same movement. A model of each follower is optionally employed to transform the observed movement of a leader to a series of movement cues that will overcome any follower physical and cognitive limitations while maximizing the movement compliance and benefit from the directed movement. Also provided is the capability of establishing a library of therapeutic, fitness, rehabilitation or dance movement scripts that may be replayed at the follower's convenience without a leader present. Additionally, one aspect provides for continually monitoring follower movement to detect unstable movement, an increased likelihood of a fall and gait anomalies and initiating a stimulus pattern to reduce the chance of a fall or injury.

Abstract: A cloud-based healthcare diagnostic and treatment platform capable of making non-invasive healthcare diagnostics and treatment recommendations based on data captured from combinations of physical activity and mental activity. In an embodiment, the system and method comprise a healthcare diagnostics and treatment module comprising a HIPPA-compliant security gateway, an AI-assisted healthcare diagnostics module, and an alert and treatments module. The HIPPA-compliant security gateway separates out health-related data from streams of data which may include other data such as game data, provides the health-related data to the AI-assisted healthcare diagnostics module which performs diagnoses of the health-related data using machine learning algorithms, and provides the diagnoses to the alert and treatments module which generates alerts and treatments based on the diagnoses.

Abstract: A method of creating a reperfusion injury can include: providing a cell culture device having an internal chamber with at least one port coupled to a perfusion modulating system capable of modulating perfusion in the internal chamber, wherein the internal chamber includes a cell culture; perfusing a fluid through the internal chamber with the perfusion modulating system, wherein the perfusion modulating system includes at least one pump; reducing fluid flow through the internal chamber; reperfusing fluid flow through the internal chamber; and creating a reperfusion injury in the cell culture by the reperfusion of the fluid flow through the internal chamber. The cell culture includes at least one type of tissue cell. The cell culture can include a tissue construct formed of hydrogel and/or extracellular matrix.

Abstract: Disclosed herein are methods, systems, and apparatus for treating a medical condition of a patient, involving detecting a physiological cycle or cycles of the patient and applying an electrical signal to a portion of the patient's vagus nerve through an electrode at a selected point in the physiological cycle(s). The physiological cycle can be the cardiac and/or respiratory cycle. The selected point can be a point in the cardiac cycle correlated with increased afferent conduction on the vagus nerve, such as a point from about 10 msec to about 800 msec after an R-wave of the patient's ECG, optionally during inspiration by the patient. The selected point can be a point in the cardiac cycle when said applying increases heart rate variability, such as a point from about 10 msec to about 800 msec after an R-wave of the patient's ECG, optionally during expiration by the patient.

Abstract: Systems and methods are provided for applying electrical stimulation to a body by an electrode spaced from a target nerve of passage. It has been discovered that pain felt, or perceived to be felt, in a given region of the body can be treated by stimulating muscle close to a “nerve of passage” in a region that is superior (i.e., cranial or upstream toward the spinal column) to the region where pain is felt, such as in a case of post-amputation residual limb pain, or purportedly felt in the case of post-amputation phantom limb pain.

Abstract: A tremor suppression device includes a garment wearable on an anatomical region and including electrodes contacting the anatomical region when the garment is worn on the anatomical region, and an electronic controller configured to: detect electromyography (EMG) signals as a function of anatomical location and time using the electrodes; identify tremors as a function of anatomical location and time based on the EMG signals; and apply neuromuscular electrical stimulation (NMES) at one or more anatomical locations as a function of time using the electrodes to suppress the identified tremors.

Abstract: Disclosed is a shift register unit set, a gate driving circuit and a display apparatus, the shift register set including: cascaded n shift register units, and an ith stage of shift register unit in the shift register unit set includes: a first input sub-circuit and a second input sub-circuit, wherein the first input sub-circuit includes: a charging sub-circuit, a storing sub-circuit, an isolating sub-circuit, an output sub-circuit, a first electric leakage prevention sub-circuit configured to input an operation potential to the isolating sub-circuit under the control of the blanking pull-up control node, and a second electric leakage prevention sub-circuit configured to input the operation potential to a second electrode of the isolating transistor under the control of the first pull-up node, wherein there is an overlap among n composite output signals output by the n shift register units, n and i are positive integers, and 1?i?n.

Abstract: A method of tracking a position of a catheter within a patient includes securing a navigational reference at a reference location within the patient, defining the reference location as the origin of a coordinate system, determining a location of an electrode moving within the patient relative to that coordinate system, monitoring for a dislodgement of the navigational reference from the initial reference location, for example by measuring the navigational reference relative to a far field reference outside the patient's body, and generating a signal indicating that the navigational reference has dislodged from the reference location. Upon dislodgement, a user may be provided with guidance to help reposition and secure the navigational reference to the initial reference location, or the navigational reference may be automatically repositioned and secured to the initial reference location. Alternatively, a reference adjustment may be calculated to compensate for the changed reference point/origin.

Abstract: A unidirectional electrode and method for sensing and stimulating the subthalamic nucleus of the brain to treat certain disorders such as epilepsy, Parkinson's, essential tremors and dystonia.

Abstract: Systems and methods use deep, convolutional neural networks over exponentially long history windows to learn alphabets for context tree weighting (CTW) for prediction. Known issues of depth and breadth in conventional context tree weighting predictions are addressed by the systems and methods. To deal with depth, the history can be broken into time windows, permitting the ability to look exponentially far back while having less information the further one looks back. To deal with breadth, a deep neural network classifier can be used to learn to map arbitrary length histories to a small output symbol alphabet. The sequence of symbols produced by such a classifier over the history windows would then become the input sequence to CTW.

Abstract: The present invention relates to methods for remotely and intelligently tuning movement disorder of therapy systems. The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson's disease and Parkinsonism, Dystonia, Chorea, and Huntington's disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of remotely and intelligently or automatically tuning a therapy device using objective quantified movement disorder symptom data and/or brain activity mapped data to determine the therapy setting or parameters to be transmitted and provided to the subject via his or her therapy device. The present invention also provides treatment and tuning intelligently, automatically and remotely, allowing for home monitoring of subjects.

Abstract: A method of operating a biological interface is disclosed. The method may include obtaining an input physiological or neural signal from a subject, acquiring an input set of values from the input signal, obtaining a predictive signal from the subject or the environment, acquiring a predictive set of values from the predictive signal, training a decoder function in response to data from the predictive set of values, performing at least one calculation on the input set of values using the decoder function to produce an output set of values, and operating a device with the output set of values. A biological interface system is also disclosed. The biological interface system may contain an input signal sensor, an input signal processor, a predictive signal processor, a memory device storing data, and a system processor coupled to the memory device and configured to execute a decoder function.

Abstract: Most particularly, the present invention relates to a customized and adaptive movement recovery system and a method of improving the functional motor recovery of a subject with a movement disorder. The present invention provides for a system and method, which in some embodiments can accurately quantify treatment device parameters and protocols including electrical stimulation amplitude (volts/amps), frequency (Hz), and pulse width (microseconds), and medication titrations, doses, and times by utilizing accelerometric, gyroscopic or other movement related information, such as electromyography (EMG) data, or the like, and a central database, or system of databases, of patient and treatment histories. In other embodiments, the system and method provide for an adaptive central database system and automated control of movement disorder treatment devices.

Abstract: A Graphical User Interface (GUI) for an external device used to program an implantable stimulator device is disclosed. The GUI includes aspects useful in adjusting the current magnitude provided at one or more of the stimulator device's electrodes. In particular, the GUI includes an amplitude slider, which allows the user to slide an indicator to increase or decrease the current magnitude at different rates depending on the length of the slide. The GUI further allows the user to prescribe drop back functionality, which reduces the current magnitude by a prescribed amount when the indicator is released. In one example, drop back functionality can be engaged in accordance with a rate threshold, and thus drop back functionality will only occur when the rate of increase equals or is above the threshold when the control button is released.

Abstract: A device for stimulating neurons that includes a stimulation unit that applies mechanically tactile and/or thermal stimuli to the body surface of a patient that stimulate neurons with a pathologically synchronous and oscillatory neural activity. The device includes a measuring unit that records measurement signals of neural activity of the stimulated neurons, and a controller that controls the stimulation unit and analyzes the measurement signals. The controller actuates the stimulation unit to scan at least one part of the body surface of the patient along a path and thereby periodically applies stimuli and also selects two regions or more regions on the patient's body surface along the path where the phase synchronization between the periodic application of the stimuli and the neural activity of the stimulated neurons have a local maximum using the measurement signals. The stimuli are then applied in a delayed manner in the two regions.

Abstract: A low-profile intercranial device adapted for housing a functional neurosurgical implant in manner providing for convenient and reliable grounding to ensure proper impedance measurements includes a static cranial implant including a base cranial implant member including an outer first surface, an inner second surface, and a recess shaped and dimensioned for receiving a functional neurosurgical implant. The low-profile intercranial device includes a plurality of fluid passageways extending between the inner second surface and the recess allowing for the flow of bodily fluid between an external environment of the base cranial implant member and a cavity defined by the recess.

Abstract: Embodiments include methods and systems for automated eating detection. Systems comprise a continuous glucose monitor (CGM), accelerometer, and processing unit. During a first time period, the processing unit receives glucose readings and a first set of acceleration readings. The processing unit identifies an eating episode if the glucose readings satisfy one or more criteria. Using the identified eating episode and first set of acceleration readings, the processing unit generates an individual model that identifies eating episodes using acceleration readings without using glucose readings. During a second time period, a processing unit uses the individual model and a second set of acceleration readings to identify a second eating episode. Some embodiments may use additional sensor types (for example, PPG or heart rate) to identify eating episodes in the first or second time period, generate the individual model, or any combination thereof.

Abstract: The present invention provides devices and methods for modulating spreading depression in the brain.

Abstract: Systems and methods for non-invasive and/or non-contact measurement of a subject's tremor in the context of therapeutic intervention is presented. The system includes a memory, a communications interface, a sensor to measure a signal associated with position or motion of an extremity of the subject, and a processor. The processor is configured to receive the signal from the sensor. The processor is further configured to communicate, via the communications interface, the signal, login credentials, and position or motion data to a remote server coupled to a remote electronic health record database. The remote server is configured to receive the signal from the sensor. The processor is configured to receive an analysis that quantified the severity of tremor.

Abstract: In a method for implantation of a physically stabilized aggregate of living cells or tissue fragment is injected into a channel provided in soft tissue filled with an aqueous gel. Also discloses are methods of stabilizing such aggregates and fragments and of forming such channel in soft tissue as well as means for carrying out the methods.