Treating Mental Or Emotional Disorder Patents (Class 607/45)
  • Patent number: 12029901
    Abstract: This disclosure describes methods and systems for preventing, moderating, and/or treating brain injury. The methods herein may include obtaining a test result reflecting a condition of a brain in the subject, determining a stimulation parameter based on the test result, and stimulating a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject. The systems herein may include a processor configured to: receive a test result reflecting a condition of a brain in a subject, and determine a stimulation parameter based on the test result; and a stimulator configured to stimulate a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: July 9, 2024
    Assignee: Lungpacer Medical Inc.
    Inventors: Douglas G. Evans, Viral S. Thakkar, Matthew J. Gani
  • Patent number: 12029581
    Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: July 9, 2024
    Assignee: NeuroPace, Inc.
    Inventors: Tara L. Crowder, Brett M. Wingeier, Martha J. Morrell, Felice Sun, Thomas Tcheng
  • Patent number: 12029701
    Abstract: An auricular peripheral nerve field stimulator may include at least one therapy electrode configured for percutaneous insertion into an auricle of a human ear near at least one neurovascular bundle located therein, and an electrical stimulation device electrically coupled to the electrical stimulation device, the electrical stimulation device programmed to generate and deliver electrical stimulation signals, with defined stimulation parameters, to the at least one therapy electrode to stimulate, with the at least one therapy electrode percutaneously inserted, at least one auricular peripheral nerve field within the auricle, the defined stimulation parameters including a defined pulse frequency and at least one of a defined pulse width and a defined duty cycle.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: July 9, 2024
    Assignee: Neuraxis, Inc.
    Inventors: Christopher R. Brown, Gary M. Peterson
  • Patent number: 12029907
    Abstract: Methods and apparatus for improving cognitive function within a human. The invention utilizes a neurostimulation device, such as a signal generator, to affect tissue elements at a lateral temporal lobe of the human brain. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various characteristics of cognition. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation therapy.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: July 9, 2024
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Michael Kahana, Daniel Sutton Rizzuto
  • Patent number: 12029894
    Abstract: In an embodiment, an electrical stimulation system can include one or more of an electrode assembly including one or more electrodes and an electronics subsystem. In some variations, each of the one or more electrodes can include a hydrophilic layer and a conductive layer. In some variations, the electronics subsystem can include one or more of a control module, power module, and a stimulus generator. In some variations, the electrical stimulation can further include one or more of an electrical attachment system, mechanical attachment system, head apparel assembly, flexible housing, and/or any other suitable component. The electrical stimulation system functions to apply electrical stimulation but can additionally or alternatively function to measure/and or record one or more biosignals from a user.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: July 9, 2024
    Assignee: Flow Neuroscience, Inc.
    Inventors: Brett Wingeier, Ian Shain, Colin Davis, Victoria Hammett, Mardis Bagley, Phnam Bagley
  • Patent number: 12023500
    Abstract: A method of treating a medical condition in a patient using an implantable medical device, the implantable medical device including a first electrode coupled to a first cranial nerve structure and a second electrode coupled to a second cranial nerve structure, the method comprising: providing a first electrical signal to the first cranial nerve structure of the patient; providing a second electrical signal to the second cranial nerve structure of the patient; administering to the patient a responsiveness test and comparing a result of the responsiveness test to a baseline responsiveness test; and initiating a second therapy or issuing a warning based on the comparison of the result of the responsiveness test to the baseline responsiveness test.
    Type: Grant
    Filed: March 8, 2023
    Date of Patent: July 2, 2024
    Assignee: Flint Hills Scientific, LLC
    Inventor: Ivan Osorio
  • Patent number: 12023501
    Abstract: Devices, systems, and techniques for controlling electrical stimulation therapy are described. In one example, a system may be configured to deliver electrical stimulation therapy to a patient, the electrical stimulation therapy comprising a plurality of therapy pulses at a predetermined pulse frequency over a period of tune and deliver, over the period of time, a plurality of control pulses interleaved with at least some therapy pulses of the plurality of therapy pulses. The system may also be configured to sense, after one or more control pulses and prior to an immediately subsequent therapy pulse of the plurality of therapy pulses, a respective evoked compound action potential (ECAP), adjust, based on at least one respective ECAP, one or more parameter values that at least partially defines the plurality of therapy pulses, and deliver the electrical stimulation therapy to the patient according to the adjusted one or more parameter values.
    Type: Grant
    Filed: September 24, 2021
    Date of Patent: July 2, 2024
    Assignee: Medtronic, Inc.
    Inventors: David A. Dinsmoor, Kristin N. Hageman, Hank Bink
  • Patent number: 12023494
    Abstract: The present invention relates to a device for performing a tVNS treatment having at least one electrode for generating a stimulation pulse, with the device having at least one detection means that is configured to detect one or more parameter values, and with the device having a control or regulation unit that is suitable to set one or more parameters of the stimulation pulse delivered by the electrode in dependence on the detected parameter value or values.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: July 2, 2024
    Assignee: TVNS TECHNOLOGIES GMBH
    Inventors: Armin Bolz, Klaus Karg
  • Patent number: 12011290
    Abstract: A medical data processing method is provided and includes: acquiring medical image data describing a digital image of an anatomical body part containing at least one nerve fibre extending between an internal part of the anatomical body part and a substantially exterior part of the anatomical body part; and acquiring atlas data describing an image-based model of the anatomical body part. The method determines, based on the medical image data and the atlas data, exterior part data describing an association between the exterior part and the nerve fibre. The method further acquires a predetermined applied stimulation signal applied to, based on the exterior part data, the exterior part and an emitted stimulation signal emitted by the nerve fibre. Correspondence measure data describing a measure of correspondence between the applied stimulation signal and the emitted stimulation signal is then determined.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: June 18, 2024
    Assignee: BRAINLAB AG
    Inventor: Bálint Varkuti
  • Patent number: 12005251
    Abstract: The present invention provides materials and methods for using electrical stimulation to treat a mammal having a proteinopathy (e.g., neurodegenerative diseases) or at risk of developing a proteinopathy are provided. For example, the present invention provides materials and methods for modulating glymphatic clearance (e.g., enhancing glymphatic clearance) of pathogenic proteins.
    Type: Grant
    Filed: August 10, 2022
    Date of Patent: June 11, 2024
    Assignees: Wisconsin Alumni Research Foundation, Mayo Foundation for Medical Education and Research
    Inventors: Justin Williams, Kip Ludwig, Erika Ross
  • Patent number: 12009785
    Abstract: In some embodiments, there is provided an apparatus including a common bus and a plurality of oscillatrode circuits coupled to the common bus, the plurality of oscillatrode circuits including a first oscillatrode circuit outputting a first frequency tone when a first input voltage is detected by the first oscillatrode circuit and a second oscillatrode circuit outputting a second frequency tone when a second input voltage is detected by the second oscillatrode circuit, wherein common bus carries the first frequency tone and the second frequency tone at different frequencies in a frequency division multiplex signal. Related systems, methods, and articles of manufacture are also disclosed.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: June 11, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jun-Chau Chien, Mohammad Amin Arbabian
  • Patent number: 12004840
    Abstract: Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: June 11, 2024
    Assignee: The Regents of the University of California
    Inventors: Michel M. Maharbiz, Dongjin Seo, Konlin Shen, Jose M. Carmena, Ryan Neely, Elad Alon, Jan Rabaey
  • Patent number: 11992671
    Abstract: The present disclosure is in the field of sleep and respiratory care. In particular, the present disclosure provides means and methods for decreasing the respiratory effort of a sleeping subject. The present disclosure also provides means and methods for treating the snoring of a sleeping subject.
    Type: Grant
    Filed: October 1, 2021
    Date of Patent: May 28, 2024
    Assignee: Sunrise SA
    Inventor: Pierre Martinot
  • Patent number: 11992289
    Abstract: A method includes using fully sampled retro cine data to train an algorithm, and applying the trained algorithm to real time MR cine data to yield reconstructed MR images.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: May 28, 2024
    Assignee: Shanghai United Imaging Intelligence Co., Ltd.
    Inventors: Zhang Chen, Xiao Chen, Shanhui Sun, Terrence Chen
  • Patent number: 11992683
    Abstract: Aspects of the subject disclosure may include, for example, a method and apparatus for measuring a bioimpedance and performing an electrical stimulation, the method including generating a first current corresponding to a first high-frequency, generating a second current corresponding to a second high-frequency, generating a low-frequency current based on a beat phenomenon of the first current and the second current, and calculating an impedance of a target part based on a voltage induced to the target part by a high-frequency current corresponding to at least one of the first current and the second current and the low-frequency current.
    Type: Grant
    Filed: March 7, 2023
    Date of Patent: May 28, 2024
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Hyungwoo Lee, Sang Joon Kim, Jongpal Kim
  • Patent number: 11975195
    Abstract: The present invention relates to methods for remotely and intelligently tuning movement disorder of therapy systems. The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson's disease and Parkinsonism, Dystonia, Chorea, and Huntington's disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of remotely and intelligently or automatically tuning a therapy device using objective quantified movement disorder symptom data to determine the therapy setting or parameters to be transmitted and provided to the subject via his or her therapy device. The present invention also provides treatment and tuning intelligently, automatically and remotely, allowing for home monitoring of subjects.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: May 7, 2024
    Assignee: Great Lakes NeuroTechnologies Inc.
    Inventors: Dustin A Heldman, Christopher L Pulliam, Joseph P Giuffrida, Thomas O Mera
  • Patent number: 11975199
    Abstract: A device may receive, from one or more electrodes, information identifying brain activity for a first time period. The device may predict, based on the information identifying the brain activity for the first time period, predicted brain activity for a second time period that is to occur after the first time period. The device may determine, based on the predicted brain activity for the second time period, a brain stimulus for the second time period, wherein the brain stimulus is associated with a frequency and a phase determined based on the predicted brain activity for the second time period. The device may cause the brain stimulus to be applied in accordance with the frequency and the phase during the second time period.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: May 7, 2024
    Assignee: The Johns Hopkins University
    Inventors: William S. Anderson, Yousef Salimpour, L. Leon Chen, Kelly Mills
  • Patent number: 11975187
    Abstract: Techniques are disclosed for delivering electrical stimulation therapy to a patient. In one example, a medical system delivers electrical stimulation therapy to a tissue of the patient via electrodes. The medical system determines a first change of a first sensed signal of the patient to movement by the patient and a second change of a second sensed signal of the patient to the movement by the patient. Based on the first change and the second change, the medical system selects one of the first sensed signal and the second sensed signal of the patient for controlling the electrical stimulation therapy. The medical system adjusts a level of at least one parameter of the electrical stimulation therapy based on the selected one of the first sensed signal and the second sensed signal.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: May 7, 2024
    Assignee: Medtronic, Inc.
    Inventors: Scott R. Stanslaski, Timothy R. Abraham, Thomas Adamski, Timothy J. Denison, Robert S. Raike
  • Patent number: 11964157
    Abstract: A system includes processing circuitry configured to determine, for each respective electrode of a plurality of electrodes, a score based on a ratio of an electrical efficiency for the respective electrode to a therapeutic window for the respective electrodes. The processing circuitry is further configured to determine, based on the score of each respective electrode, a ranking of the plurality of electrodes, and to select, based on the ranking, a subset of the plurality of electrodes for delivery of electrical stimulation therapy.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: April 23, 2024
    Assignee: Medtronic, Inc.
    Inventor: Janardan Vaidyanathan
  • Patent number: 11964155
    Abstract: A method of rapid frequency cycling during electrical stimulation according to an embodiment may include determining, by a controller of an electrical stimulation system, a plurality of frequency band groupings of discrete frequency bands of an electrical stimulation signal having a frequency range, wherein each frequency band grouping includes at least one discrete frequency band, wherein a corresponding current or voltage amplitude of the electrical stimulation signal is independently tuned within each discrete frequency band based on feedback received from a patient, determining, by the controller, a random sequence of the frequency band groupings of the plurality of frequency band groupings, generating, by at least one signal generator controlled by the controller, the electrical stimulation signal according to the determined random sequence of the frequency band groupings, and delivering the generated electrical stimulation signal through an electrode array to the patient to provide therapy to the patien
    Type: Grant
    Filed: July 14, 2023
    Date of Patent: April 23, 2024
    Assignee: Soin Neuroscience, LLC
    Inventors: Amol Soin, Eric A. Schepis
  • Patent number: 11957909
    Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
    Type: Grant
    Filed: November 23, 2019
    Date of Patent: April 16, 2024
    Assignee: FLINT HILLS SCIENTIFIC, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 11950931
    Abstract: A cured electrode comprising a mixture comprising conductive elements and a carrier which, upon injection into a body, cures from a liquid phase at a first time to a biocompatible solid phase at a second time at or on a target tissue within the body. The cured electrode is capable of being molded around contours of the target tissue so that, after curing, the cured electrode retains the contours of the target tissue. The cured electrode is capable of conducting electricity at a resistance of less than 10 ohm meters in the liquid or the solid phases. Carrier materials include hydgrogel, silicone, bone cement, cyanoacrylate, dental resin and a fibrin mix. The carrier material may also be used to anchor the cured electrode and provide great stability.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: April 9, 2024
    Assignee: NEURONOFF, INC.
    Inventors: Manfred Franke, Andrew Shoffstall, John W. Sheets, Jr.
  • Patent number: 11944806
    Abstract: Electrostimulation systems and methods are contemplated in which a high current level, charge balanced alternating current electrical signal is generated for delivery to the frontal cortex region of a patient's brain. By stimulating this region of the brain with a charged balanced stimulation current with a stimulation current envelope defining one or more series of pulses at particular frequencies and durations designed to evoke metabolic response in the neurons, significant improvements in efficacy and reductions in patient discomfort may be achieved relative to earlier methods of transcranial electrical stimulation, especially those in which result in a resultant rectified direct current component being administered to the patient.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: April 2, 2024
    Assignee: NEXALIN TECHNOLOGY, INC.
    Inventor: John Patrick Claude
  • Patent number: 11931576
    Abstract: An illustrative system includes a behind-the-ear (BTE) sound processor configured to be worn by a patient behind an ear of the patient. The BTE sound processor is configured to direct a cochlear implant implanted within the patient to apply electrical stimulation to the patient. The system further includes a conductive contact configured to detect a signal representative of an evoked response generated by a brain of the patient. The conductive contact is integrated with the BTE sound processor so as to be located between the BTE sound processor and an external surface of a head of the patient while the BTE sound processor is worn by the patient behind the ear of the patient. Corresponding systems and methods are also disclosed.
    Type: Grant
    Filed: November 11, 2021
    Date of Patent: March 19, 2024
    Assignee: Advanced Bionics AG
    Inventor: Kanthaiah Koka
  • Patent number: 11931208
    Abstract: The present application discloses a cerebral perfusion state classification apparatus and method, a device, and a storage medium. The method includes: acquiring, by a transceiving module, cervical blood flow data from an ultrasound data collecting device; determining, by a processor, cerebral perfusion data corresponding to the cervical blood flow data based on the cervical blood flow data and a mapping relationship between the cervical blood flow data and the cerebral perfusion data, and classifying cerebral perfusion states of a plurality of brain regions based on blood perfusion characteristics of the plurality of brain regions in the cerebral perfusion data.
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: March 19, 2024
    Assignee: BEIJING FRIENDSHIP HOSPITAL, CAPITAL MEDICAL UNIVERSITY
    Inventors: Zhenchang Wang, Wei Zheng, Han Lv, Pengling Ren, Dehong Luo, Linkun Cai, Yawen Liu, Hongxia Yin, Pengfei Zhao, Jing Li, Dong Liu, Erwei Zhao, Tingting Zhang
  • Patent number: 11931574
    Abstract: A system for controlling delivery of electrical stimulation to a subject. The system comprises a control device configured to send stimulation instructions to an electrical stimulation generator to cause the electrical stimulation generator to deliver transcranial electrical stimulation to one or more electrodes arranged to be positioned in proximity to a targeted region of the brain of the subject. The stimulation instructions comprise stimulation parameter value(s). The control device is configured to receive sensor data from optical sensor(s) arranged to be positioned in proximity to the targeted region and transmit updated stimulation instructions comprising updated simulation parameter value(s) to the electrical stimulation generator to cause the electrical stimulation generator to modify characteristic(s) of the stimulation. The system is configured to analyse the sensor data to determine an activity measure and determine updated stimulation parameter value(s) based on the determined activity measure.
    Type: Grant
    Filed: August 21, 2023
    Date of Patent: March 19, 2024
    Assignee: Neurode Pty Ltd
    Inventors: Nathalie Gouailhardou, Damian Sofrevski
  • Patent number: 11931581
    Abstract: In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes. The parameters may be defined based on a first plurality of electrical signals sensed at a plurality of different positions within the brain of the patient when electrical stimulation is not delivered at each of the positions and a second plurality of electrical signals sensed at each of the plurality of different positions within the brain of the patient in response to electrical stimulation delivered at each of the positions at a plurality of different intensities.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: March 19, 2024
    Assignee: Medtronic, Inc.
    Inventors: Jianping Wu, Dwight E. Nelson, Gabriela C. Molnar
  • Patent number: 11925806
    Abstract: Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: March 12, 2024
    Assignee: Medtronic, Inc.
    Inventors: Jonathon E. Giftakis, Paul H. Stypulkowski
  • Patent number: 11911619
    Abstract: The present disclosure provides a method and system for treating affective disorders such as depression and/or anxiety and/or related disorders through neuromodulatory intervention that includes brain targets within the orbitofrontal cortex (OFC). This method includes the application of electrical stimulation through an electrical signal generator device where the distal end of the device comprises at least one stimulating electrode in contact with the OFC. The treatment system includes patient selection, implantation of at least one stimulating electrode in contact with the OFC, acute or chronic electrical stimulation of the OFC, and evaluation of the effects of stimulation on clinical symptoms and status.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: February 27, 2024
    Assignee: The Regents of the University of California
    Inventor: Edward F. Chang
  • Patent number: 11911620
    Abstract: Disclosed are devices, systems and methods for non-invasive neuromodulation system for prompt treatment of cerebral and/or ocular strokes caused by acute dysregulated reduced cerebral blood flow (CBF) and/or ocular blood flow (OBF) by up regulation of trigemino-vascular system (TVS), and trigeminal autonomic brain reflexes (TABRs) through stimulation of ophthalmic nerve. Additionally or alternatively, the subject's sympathetic nervous system (SNS) is down regulated centrally by intravenous administration of pharmacological dose of ascorbic acid. The site of stimulation of ophthalmic nerve includes but not limited to nasal vestibule, nasal bridge, and forehead and upper eyelid. In some embodiments, the devices are handheld, portable with nose supported, having one or more intra-nasal or extra-nasal application heads. The signal can include vibration, chemical, ultrasonic, optical, electrical, hybrid electro-optical or combination of two or more of these types of stimuli.
    Type: Grant
    Filed: July 19, 2020
    Date of Patent: February 27, 2024
    Inventor: Ismail Mohammed Yousif Musallam
  • Patent number: 11903718
    Abstract: An automatic noise signal interval detection method and device are provided, and the method includes receiving input data and generating initial data in a time-frequency domain, calculating power for each epoch for each channel of the initial data, generating a power graph for a specific frequency region of each channel based on the power for each epoch, generating a baseline based on an average of each channel value on the power graph, and determining, as a noise signal interval, an interval exceeding a predetermined threshold based on the baseline on the power graph.
    Type: Grant
    Filed: December 2, 2021
    Date of Patent: February 20, 2024
    Assignee: IMEDISYNC, LTD.
    Inventors: Seung Wan Kang, Ukebo Park
  • Patent number: 11896833
    Abstract: An invention and method that generate dynamical shaped voltage-gradient geometries through a plurality of dual-modal electrode-contacts placed around the biological tissue in vivo. The geometry of the voltage gradient is optimized through a feedback mechanism from the plurality of dual-modal electrode-contacts that can record electric and magnetic field potentials in the biological tissue. A control controls the waveform signal between sets of electrode-contacts to generate dynamically shaped voltage gradients to modulate a specific set of properties in the biological tissue. A method of analysis for the recorded electric and magnetic field potentials is purposed to optimize the shape of the voltage-gradient geometry through modulation of the waveform signal that is sent through the dual-modal electrode-contacts.
    Type: Grant
    Filed: December 11, 2022
    Date of Patent: February 13, 2024
    Assignee: U LLC
    Inventors: Mohammed Abouelsoud, David J. Mishelevich
  • Patent number: 11896440
    Abstract: A medical delivery system including a carrier and a lead delivery device. The carrier defines a carrier body configured to engage a stereotactic system (or a similar pointing device with or without navigation/robotic assistance). The carrier defines a carrier channel configured to engage the lead delivery device and impart a torque to a portion of the lead delivery device. The lead delivery device and carrier are configured to cause the imparted torque to cause a cannula of the lead delivery device to rotate about a longitudinal axis of the lead delivery device. The cannula is configured to cause a rotation of an implantable lead within the cannula when the cannula is caused to rotate. The cannula is configured to translate substantially parallel to the longitudinal axis relative to the implantable lead.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: February 13, 2024
    Assignee: Medtronic, Inc.
    Inventors: Janardan Vaidyanathan, Charles T. Graves
  • Patent number: 11890477
    Abstract: A system for delivering electrical pulse stimulation to a subject includes a remote control device configured to at least intermittently transmit temporal pulse pattern programming and a stimulation device comprising a control interface, at least one electrode in electrical communication with the control interface, and an input device in at least intermittent communication with the remote control device to receive the temporal pulse pattern programming. The stimulation device is configured to deliver electrical pulse stimulation to a subject via the at least one electrode according to the temporal pulse pattern programming.
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: February 6, 2024
    Assignee: Duke University
    Inventors: Warren M. Grill, Tianhe Zhang
  • Patent number: 11883670
    Abstract: Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.
    Type: Grant
    Filed: January 26, 2021
    Date of Patent: January 30, 2024
    Assignee: Nevro Corp.
    Inventors: Andre B. Walker, Zi-Ping Fang, Anthony V. Caparso
  • Patent number: 11872401
    Abstract: A stimulation device includes an adaptor component. The adaptor component couples a percutaneous lead to the stimulation device. The stimulation device may apply a stimulation signal to target tissue via the adaptor. A surgeon may place the stimulation device in a container and the adaptor component may be disposed outside of the container. Methods describe prolonged stimulation of target tissue via a stimulation device. The prolonged stimulation may be applied during and after a surgical procedure.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: January 16, 2024
    Assignee: CHECKPOINT SURGICAL, INC.
    Inventors: Kevin Scanlan, Eric R. Walker, Leonard M. Cosentino
  • Patent number: 11862338
    Abstract: The present disclosure relates to systems and methods for accessing a data structure including a subject identifier identifying a subject and a subject connectivity value derived from at least one of a scan or test provided to the subject, the subject connectivity value representing a magnitude of a connection associated with at least one sub-processing region of a nervous system of the subject; comparing the subject connectivity value to a connectivity threshold value to determine a classification of the subject; determining that the subject connectivity value exceeds the connectivity threshold value, storing in the data structure, an association between the subject identifier and a first classification value corresponding to a first classification or determining that the subject connectivity value is less than the connectivity threshold value, and storing in the data structure, an association between the subject identifier and a second classification value corresponding to a second classification.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: January 2, 2024
    Assignee: Click Therapeutics, Inc.
    Inventors: Brian M. Iacoviello, Dennis Charney
  • Patent number: 11857811
    Abstract: Systems and methods are disclosed related to using acoustic waves to detect neural activity in a brain and/or localize the neural activity in the brain. Sensors positioned outside of a skull encasing the brain can detect acoustic waves associated with the neural activity in the brain. From output signals of the sensors, a particular type of neural activity (e.g., a seizure) can be detected. A location of the neural activity can be determined based on outputs of the sensors. In some embodiments, the ultrasound energy can be applied to the location of the neural activity in response to detecting the neural activity.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: January 2, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Butrus T. Khuri-Yakub, Kamyar Firouzi, George Quintin Stedman
  • Patent number: 11857788
    Abstract: Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.
    Type: Grant
    Filed: January 4, 2023
    Date of Patent: January 2, 2024
    Assignee: The Feinstein Institutes for Medical Research
    Inventor: Kirk R. Manogue
  • Patent number: 11857786
    Abstract: A method and apparatus for transdermally providing electrical current to a region of a user's head at high impedance conditions, while maintaining low voltage levels.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: January 2, 2024
    Assignee: NEUROLIEF LTD.
    Inventors: Ron Belson, Yaniv Matza, Amit Dar, Amir Cohen
  • Patent number: 11850428
    Abstract: A system for treating obstructive sleep apnea (OSA) is described. The system may include a device having a size and shape selected to couple externally to a patient near a jaw of the patient. The device may be configured to receive at least one of a needle or an introducer for insertion into a tongue of the patient for lead placement of a lead for OSA treatment, and guide at least a portion of the at least one of the needle or introducer for insertion into the tongue of the patient.
    Type: Grant
    Filed: December 13, 2021
    Date of Patent: December 26, 2023
    Assignee: Medtronic Xomed, Inc.
    Inventors: Avram Scheiner, David C. Hacker
  • Patent number: 11832914
    Abstract: An example method is performed by a computing device executing instructions stored in data storage, and includes receiving physiologic monitoring data from a plurality of sensors coupled to a patient, receiving information indicating a measurement of patient motion during the patient care event, determining whether the measurement of patient motion is above a threshold, based on determining whether the measurement of patient motion is above the threshold, generating, for the physiologic monitoring data, a respective quality indicator, analyzing, by the computing device, (i) a combination of the physiologic monitoring data from the plurality of sensors and (ii) the respective quality indicator for the physiologic monitoring data to generate a response dependent upon the combination of the physiologic monitoring data as weighted by the respective quality indicator, and based on analyzing, outputting caregiver feedback by the computing device according to the response.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: December 5, 2023
    Assignee: Physio-Control, Inc.
    Inventors: Clinton T. Siedenburg, Tyson G. Taylor, Robert G. Walker, Fred W. Chapman
  • Patent number: 11832948
    Abstract: The provided systems, methods and devices describe lightweight, wireless tissue monitoring devices that are capable of establishing conformal contact due to the flexibility or bendability of the device. The described systems and devices are useful, for example, for skin-mounted intraoperative monitoring of nerve-muscle activity. The present systems and methods are versatile and may be used for a variety of tissues (e.g. skin, organs, muscles, nerves, etc.) to measure a variety of different parameters (e.g. electric signals, electric potentials, electromyography, movement, vibration, acoustic signals, response to various stimuli, etc.).
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: December 5, 2023
    Assignees: NORTHWESTERN UNIVERSITY, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: John A. Rogers, Michel Kliot, Roozbeh Ghaffari, YuHao Liu
  • Patent number: 11832956
    Abstract: A system and method for finding a Pareto-optimal solution for automated detection, warning, and abatement of a medical condition based on a cost of event intervention in a patient is disclosed. The method includes acquiring at least one biological signal from the patient via at least one sensor of a medical device, detecting an abnormal biological event based on changes in the biological signal, and delivering at least one of a therapy and a warning. The method includes logging a set of parameters including at least one of a detection parameter, a therapy parameter, and a therapy modality. The method includes identifying an optimal set of parameters that yield a Pareto-optimal cost of event intervention by iteratively determining at least one metric over a time window, determining the cost of event intervention, and modifying at least one parameter, until the cost of event intervention meets an acceptability criteria.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: December 5, 2023
    Inventor: Ivan Osorio
  • Patent number: 11826570
    Abstract: Systems and techniques are disclosed to adjust programming of an implantable electrical neurostimulation device for treating chronic pain of a human subject, through the use of a dynamic model adapted to identify pain treatment parameters for a human patient and determine a best device operational program to implement the pain treatment parameters to address the chronic pain condition. In an example, the system to adjust programming of the neurostimulation device performs operations that: obtain data related to a state of pain of the human subject; identify pain treatment parameters using a dynamic model adapted to evaluate the pain treatment parameters in the human subject over a time period, based on the data related to the state of pain; and select a neurostimulation program for the neurostimulation device, corresponding to at least a portion of the identified pain treatment parameters.
    Type: Grant
    Filed: June 23, 2022
    Date of Patent: November 28, 2023
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Qinghuang Lin, Jeffrey Rogers, Giovanni Russo, Andrea Simonetto, Tigran Tchrakian
  • Patent number: 11816796
    Abstract: Provided is a stimulation simulation method, server and, computer program using a brain model of a brain lesion patient. The stimulation simulation method using a brain model of a brain lesion patient according to various embodiments of the present invention is a stimulation simulation method using a brain model of a brain lesion patient performed by a computing device, the method includes: collecting brain images of the brain lesion patient; generating the brain model for the brain lesion patient by using the collected brain images; and simulating stimulation to the brain of the brain lesion patient by using the generated brain model.
    Type: Grant
    Filed: February 22, 2022
    Date of Patent: November 14, 2023
    Assignee: NEUROPHET Inc.
    Inventor: Dong Hyeon Kim
  • Patent number: 11801004
    Abstract: Provided are systems, methods, and devices for intracranial measurement, stimulation, and generation of brain state models. Systems include a plurality of intracranial electrodes configured to be coupled to a brain of a user. Systems further include an interface configured to obtain measurements from the plurality of intracranial electrodes. Systems include a first processing device including one or more processors configured to generate a plurality of brain state parameters characterizing one or more features of at least one brain state of the user, and a second processing device including one or more processors configured to generate at least one model of the brain of the user based, at least in part, on the plurality of brain state parameters and the measurements. Systems include a controller including one or more processors configured to generate a control signal based on the plurality of brain state parameters and the at least one model.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: October 31, 2023
    Assignee: STIMSCIENCE, INC.
    Inventor: Anantha K. Pradeep
  • Patent number: 11793443
    Abstract: A method of providing therapy to a patient according to one embodiment includes partitioning a frequency range into a plurality of discrete frequency bands with each having a corresponding bandwidth, generating a composite electrical signal based on a plurality of periodic signals, wherein each periodic signal has a frequency within a corresponding frequency band of the plurality of discrete frequency bands, delivering the composite electrical signal through one or more electrodes to the patient to target at least one of neural tissue or non-neural tissue of the patient, adjusting an amplitude of one or more of a voltage or a current of the composite electrical signal within a selected frequency band of the plurality of discrete frequency bands to generate an adjusted signal based on feedback received from the patient, and delivering the adjusted electrical signal through the one or more electrodes to provide therapy to the patient.
    Type: Grant
    Filed: November 9, 2022
    Date of Patent: October 24, 2023
    Assignee: Soin Neuroscience, LLC
    Inventors: Eric A Schepis, Amol Soin
  • Patent number: 11791026
    Abstract: A cloud-based healthcare diagnostic and treatment platform capable of making non-invasive healthcare diagnostics and treatment recommendations based on data captured from combinations of physical activity and mental activity. In an embodiment, the system and method comprise a healthcare diagnostics and treatment module comprising a HIPPA-compliant security gateway, an AI-assisted healthcare diagnostics module, and an alert and treatments module. The HIPPA-compliant security gateway separates out health-related data from streams of data which may include other data such as game data, provides the health-related data to the AI-assisted healthcare diagnostics module which performs diagnoses of the health-related data using machine learning algorithms, and provides the diagnoses to the alert and treatments module which generates alerts and treatments based on the diagnoses.
    Type: Grant
    Filed: March 22, 2023
    Date of Patent: October 17, 2023
    Assignee: BLUE GOJI LLC
    Inventor: Coleman Fung
  • Patent number: 11786147
    Abstract: Aspects describe capturing the dynamic movement of one or more leaders and generating stimulus signals in real time for one or more followers to perform substantially the same movement. A model of each follower is optionally employed to transform the observed movement of a leader to a series of movement cues that will overcome any follower physical and cognitive limitations while maximizing the movement compliance and benefit from the directed movement. Also provided is the capability of establishing a library of therapeutic, fitness, rehabilitation or dance movement scripts that may be replayed at the follower's convenience without a leader present. Additionally, one aspect provides for continually monitoring follower movement to detect unstable movement, an increased likelihood of a fall and gait anomalies and initiating a stimulus pattern to reduce the chance of a fall or injury.
    Type: Grant
    Filed: February 22, 2020
    Date of Patent: October 17, 2023
    Inventor: Frederick Michael Discenzo