Treating Mental Or Emotional Disorder Patents (Class 607/45)
  • Patent number: 10773084
    Abstract: Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: September 15, 2020
    Assignee: Duke University
    Inventors: Warren M. Grill, David T. Brocker
  • Patent number: 10762988
    Abstract: A method for motor training comprising: receiving from one or more sensors an orientation of a head mounted display of the subject; adapting a base video signal representing an avatar of the subject in a virtual reality to be displayed on the head mounted display wherein the avatar comprises a virtual limb corresponding to the limb that is injured; and sending the base video signal to the head mounted display for visualization. The method further comprises in response to a trigger signal from the subject, sending an exercise video signal representing the avatar in the virtual reality performing an exercise to start the visual rendering of the exercise in the head mounted display, even though the corresponding real limb is substantially immobile and provides no input at all. Such exercise is aimed at rehabilitation of the limb from the injury with the virtual limb corresponding to the immobile limb and it is displayed taking into account the orientation of the head mounted display.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: September 1, 2020
    Assignees: UNIVERSITAT DE BARCELONA, INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS), INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
    Inventors: Mavi Sánchez Vives, Mel Slater
  • Patent number: 10758732
    Abstract: The present invention relates to methods for remotely and intelligently tuning movement disorder of therapy systems. The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson's disease and Parkinsonism, Dystonia, Chorea, and Huntington's disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of remotely and intelligently or automatically tuning a therapy device using objective quantified movement disorder symptom data and/or brain activity mapped data to determine the therapy setting or parameters to be transmitted and provided to the subject via his or her therapy device. The present invention also provides treatment and tuning intelligently, automatically and remotely, allowing for home monitoring of subjects.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: September 1, 2020
    Assignee: Great Lakes NeuroTechnologies Inc.
    Inventor: Dustin A. Heldman
  • Patent number: 10748315
    Abstract: In a control method for a screen display of a medical imaging system, an image data set of a patient is acquired and a comparison of the acquired image data set is made with a number of pre-stored image data sets, each of which is stored with layout parameters for the screen display associated therewith. Display of the acquired image data set take place with the layout parameters of the pre-stored image data set that has the greatest similarity with the acquired image data set.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: August 18, 2020
    Assignee: Siemens Healthcare GmbH
    Inventors: Sven Kohle, Andreas Prause, Maria Kroell
  • Patent number: 10743810
    Abstract: The use of a device to measure patient sensory response through the application of an incrementally increased electrical current to the oropharynx.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: August 18, 2020
    Assignee: Phagenesis Limited
    Inventor: Conor Mulrooney
  • Patent number: 10744324
    Abstract: A gait management apparatus applies stimulation to a user suffering from a neurological disease (such as Parkinson's Disease) gait dysfunction. Motion sensors are arranged to be worn by a patient, and electrical stimulation electrodes are on the legs for stimulation. A controller receives motion sensing signals, and processes these signals to generate stimulation signals for operation of the electrodes to stimulate limb movement upon detection of a gait abnormality. There may be a user actuator for user actuation of electrical stimulation, and the inputs may be a series of taps. The controller may provide signals to prevent occurrence of freezing of gait when it senses that a patient is walking or has an intention to walk. Also, it may apply stimulation at an intensity level which is insufficient for functional muscle stimulation but sufficiently high to trigger activation of efferent nerves.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: August 18, 2020
    Assignee: National University of Ireland, Galway
    Inventors: Gearóid Ó Laighin, Leo Quinlan, Dean Sweeney, Gavin Corley, James Feehilly, Patrick Browne
  • Patent number: 10736564
    Abstract: Systems and related methods for enhancing learning of a motor task are described. The system controls delivery of an example or prompt to the subject via one or more of an audio, video, or other output device. A learning enhancing transcutaneous neural stimulus is delivered in association with the example or prompt. Electrical control circuitry controls timing of delivery of neural stimuli and prompts or examples. The system may be implemented in connection with a personal computing device, for example.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: August 11, 2020
    Assignee: Elwha LLC
    Inventors: Eleanor V. Goodall, Roderick A. Hyde, Eric C. Leuthardt, Stephen L. Malaska, Elizabeth A. Sweeney
  • Patent number: 10737100
    Abstract: A medical device stores a set of stimulation profiles, wherein each stimulation profile of the set of stimulation profiles is associated with a set of values for stimulation parameters; selects from the set of stimulation profiles, one or more active stimulation profiles; produces, by a stimulation generator, multiple electrical pulses based on the one or more active stimulation profiles; and separately controls parameter values of respective individual pulses of the multiple pulses.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: August 11, 2020
    Assignee: Medtronic, Inc.
    Inventors: Erik J. Peterson, Mandla Shongwe
  • Patent number: 10734104
    Abstract: Data related to the adherence of a patient to a therapy regime can be collected from multiple medical devices, each of which may have an incomplete data set with data entries associated with times. Each incomplete data set represents a portion of a complete data set. The data sets can be integrated to create a complete data set with data entries from each incomplete data set being arranged in a temporal sequence with respect to one another. A report may be generated, the report having the data entries of the complete data set or a function of the data entries of the complete data set.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: August 4, 2020
    Assignee: Fisher & Paykel Healthcare Limited
    Inventors: Adam John Darby, Donald Roy Kuriger, Bernhard Florian Lamprecht, Mark Samuel Hamilton, Alex Young, Benjamin Wilson Casse
  • Patent number: 10729352
    Abstract: An implantable device includes one or more electrodes to sense an electrical signal from a brain and a waveform analyzer to identify a half wave in the electrical signal; determine an amplitude and a duration of the half wave; determine if the amplitude satisfies a half wave amplitude criterion defined by a set of amplitude parameters comprising a minimum half wave amplitude and a maximum half wave amplitude; determine if the duration satisfies a half wave duration criterion defined by a set of duration parameters comprising a minimum half wave duration and a maximum half wave duration; and identify the half wave as a qualified half wave when the half wave amplitude criterion and the half wave duration criterion is satisfied. A neurological event may be detected based on one or more qualified half waves and electrical stimulation therapy may be delivered to the brain in response to the detection.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: August 4, 2020
    Assignee: NeuroPace, Inc.
    Inventor: Rosana Esteller
  • Patent number: 10729907
    Abstract: Information relevant to making clinical decisions for a patient is identified based on electrical activity records of the patient's brain and electrical activity records of other patients' brains. A deep learning algorithm is applied to an electrical activity record of the patient, i.e., an input record, and to a set of electrical activity records of other patients, i.e., a set of search records, to obtain an input feature vector of the patient and a set of search feature vectors, each including features extracted by the deep learning algorithm. A similarities algorithm is applied to the input feature vector and the set of search feature vectors to identify a subset of search records most like the input record. Clinical information associated with one or more search records in the identified subset of search records is extracted from a database and used to make decisions regarding the patient's neuromodulation therapies.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: August 4, 2020
    Assignee: NeuroPace, Inc.
    Inventors: Sharanya Arcot Desai, Thomas K. Tcheng
  • Patent number: 10729908
    Abstract: Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: August 4, 2020
    Assignee: Medtronic, Inc.
    Inventors: Jonathon E. Giftakis, Paul H. Stypulkowski
  • Patent number: 10722150
    Abstract: A method for improving subject's spatial cognition and spatial memory includes presenting spatial information to the person through non-visual means, parcellating the image to enhance understanding of the nature and relationships of the image components to augment image memory, drawing the image, detecting and encoding the errors in the drawing, and providing interactive feedback based on the individual's drawing performance. The methodology includes audio-haptic feedback to present the spatial image information non-visually using an audible signal that varies as a function of the distance of the finger/stylus from the regions of a display that express the image features.
    Type: Grant
    Filed: June 2, 2019
    Date of Patent: July 28, 2020
    Inventors: Lora T. Likova, Zlatko Kristev Minev
  • Patent number: 10716945
    Abstract: An external unit for an implantable neuro stimulator system and a method of operating the same, comprising an external coil inductively couplable to an implant coil of an implantable neural stimulator unit when in close proximity to each other. An RF-signal generating module for generating and outputting an RF-signal to the coil for inductive power and/or data transfer to the implantable neural stimulator unit, a measurement unit connected to the coil for measurement of an electrical parameter at the coil and a controller connected to the measurement unit and comprising a comparator and a storage for storing the electrical parameter.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: July 21, 2020
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventors: Josef Baumgartner, Martin Zimmerling
  • Patent number: 10716941
    Abstract: Systems and methods are provided for an implantable neurostimulator system comprising an array of microelectrodes, a pair of current drivers, and a dynamic current allocation network (DCAN). Each current driver in the pair of current drivers is configured to deliver a respective portion of an electrical signal to the array of microelectrodes to deliver the desired electrical stimulation through the array of microelectrodes to the subject. The DCAN is coupled to the pair of current drivers and the array of microelectrodes to selectively electrically connect each of the pair of the current drivers to individual microelectrodes in the array of microelectrodes to deliver the electrical signal to selective collections of less than all microelectrodes in the array of microelectrodes to deliver the desired electrical stimulation. The pair of current drivers and the DCAN are arranged in respective or a common housing configured to be implanted into the subject.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: July 21, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Zhi Yang, Anh Tuan Nguyen, Jian Xu
  • Patent number: 10707773
    Abstract: An energy acquisition and power supply system is provided. The power supply system includes a plurality of power elements, each of the power elements including a transistor capable of conduction path switching, a current regulator having a dynamic substrate selection circuit and a reverse leakage current suppression circuit as well as a voltage regulator, wherein the dynamic substrate selection circuit selects a substrate potential of the transistor capable of conduction path switching dynamically to reduce a substrate leakage current of the transistor capable of conduction path switching, and the reverse leakage current suppression circuit is utilized for switching the power element at a local end to reduce transient reverse leakage current and current consumption of the power element at the local end for an input voltage, such that an output current for the power element at the local end is maximized.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: July 7, 2020
    Assignee: NATIONAL CHENG KUNG UNIVSERSITY
    Inventors: Shuenn-Yuh Lee, Chih-Hung Lee, Zhan-Xian Liao
  • Patent number: 10688303
    Abstract: Target tissue sites for therapy delivery to a patient may be selected based on the patient symptoms or a patient mood state. The therapy delivery may be used to manage a psychiatric disorder of the patient. Selected therapy sites may be weighted based on factors, such as the severity of the patient symptom or mood state or the type of patient symptom or mood state. In some cases, therapy delivery to the patient may be controlled based on the weighting factors. For example, the weighting factors may control the intensity of the therapy delivery or the frequency of the therapy delivery. In some examples, the weighting factors may dynamically change based on the patient's changing symptoms or mood disorders.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: June 23, 2020
    Assignee: MEDTRONIC, INC.
    Inventors: Mark T. Rise, Jonathon E. Giftakis
  • Patent number: 10682490
    Abstract: A method includes administering a non-invasive stimulus to a subject having a frequency of about 35 Hz to about 45 Hz to induce synchronized gamma oscillations in at least one brain region of the subject.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: June 16, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Li-Huei Tsai, Emery Brown, Hannah Iaccarino, Anthony James Martorell, Chinnakkaruppan Adaikkan
  • Patent number: 10668287
    Abstract: In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: June 2, 2020
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Andrew P. Kramer, Jason J. Hamann
  • Patent number: 10639468
    Abstract: The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: May 5, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ian A. Cook, Christopher M. DeGiorgio
  • Patent number: 10625082
    Abstract: A computing device executes a software program that communicates various deep brain stimulation (DBS) routines to a neurostimulator. The software program generates a graphical user interface (GUI) that receives inputs that are indicative of a patient's response to the various DBS routines. The GUI further includes a representation of each of one or more electrode leads that are connected to the neurostimulator. Based on the patient response inputs, one or more symbols that are indicative of an effectiveness of the stimulation routines are displayed at positions on the lead representations that correspond to parameters of the stimulation routines.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: April 21, 2020
    Assignee: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
    Inventor: Fabio Laghi
  • Patent number: 10625081
    Abstract: Disclosed in an improved medical implantable device system including an improved external charger that is able to communicate with an external controller and IPG using the communication protocol (e.g., FSK) used to implement communications between the external controller and the implant. The external controller as modified uses its charging coil to charge the implant, and also to communicate with the other devices in the system. As such, the external charger is provided with transceiver circuitry operating in accordance with the protocol, and also includes tuning circuitry to tune the coil as necessary for communications or charging. Communication or charging access to the charging coil in the external charger is time multiplexed. The disclosed system allows charging information to be provided to the user interface of the external controller so that it can be reviewed by the user, who may take corrective action if necessary.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: April 21, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Daniel Aghassian
  • Patent number: 10610121
    Abstract: A method for desynchronizing a pathological neural oscillations, includes identifying a first subpopulation of the neurons involved in the pathological neural oscillation that are in alignment with each other within a predetermined angular stimulation range, and a second subpopulation that are both (A) in alignment with each other within the predetermined angular stimulation range, and (B) out of alignment with the first neurons by at least the predetermined angular stimulation range, and applying electrical stimuli to the first and second subpopulations through scalp electrodes, the electrical stimuli being out of phase with the pathological neural oscillations for desynchronizing the pathological neural oscillations.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: April 7, 2020
    Assignee: Brain Electrophysiology Laboratory Company, LLC
    Inventors: Don M. Tucker, Phan Luu
  • Patent number: 10596379
    Abstract: An apparatus for treating neurological disorders comprising at least one electrode implantable in a patient's brain and a processing and stimulation device connected to the at least one electrode. The processing and stimulation device comprises at least one stimulation module adapted to generate a stimulation signal characterised by a plurality of parameters; at least one acquisition module adapted to acquire a signal characteristic of cerebral activity and determine its power in at least one frequency band; and at least one control module of at least one parameter of the stimulation signal as a function of the power of the signal characteristic of cerebral activity acquired, based on a transfer function having a saturating trend, wherein the transfer function is configured to set the at least one parameter of the stimulation signal differently dependent on a plurality of power ranges, by keeping the parameter within a predetermined stimulation range.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: March 24, 2020
    Assignee: NEWRONIKA S.R.L.
    Inventors: Mattia Arlotti, Alberto Priori, Lorenzo Rossi
  • Patent number: 10596372
    Abstract: Described is a system to accelerate memory consolidation using a steerable transcranial intervention. During operation, the system generates a unique transcranial and steerable stimulation tag to associate with memory of a task or event. Once the tag is generated, the system activates a plurality of electrodes (e.g., as few as four) to apply the unique transcranial stimulation tag during the occurrence of the event or task to be consolidated.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: March 24, 2020
    Assignee: HRL Laboratories, LLC
    Inventors: Michael D. Howard, Praveen K. Pilly
  • Patent number: 10588534
    Abstract: Systems and methods are disclosed to detect and/or classify electrophysiological signals as motor events.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: March 17, 2020
    Assignee: Colorado Seminary, which owns and operates the University of Denver
    Inventors: Mohammad H. Mahoor, Soroush Niketeghad, Adam O. Hebb, Sara J. Hanrahan, Joshua Nedrud, Hosein M. Golshan
  • Patent number: 10586614
    Abstract: A computer-assisted method to timely provide notifications of treatments, the method including receiving de-identified longitudinal medical records, each de-identified longitudinal medical record representing a record of a different anonymized patient and encoding information identifying a treatment received by the anonymized patient and receiving notification data including notification records, each notification record encoding information identifying a channel through which the notification was provided. The method includes determining a first channel impact model representing an impact of a notification provided through a first channel on a treatment being received, a second channel impact model representing an impact of a notification provided through a second channel on a treatment being received, and determining a multi-channel impact model representing an impact of notifications being provided through both the first channel and the second channel on a treatment being received.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: March 10, 2020
    Assignee: IQVIA Inc.
    Inventors: Yong Cai, Bob Doyle, Dong Dai, Wenzhe Lu, Emily Zhao, Steven Rosztoczy
  • Patent number: 10583294
    Abstract: Representative embodiments are directed to detecting neurological activity in a patient. The detection of neurological activity includes identifying cross-frequency coupling and determining whether the cross-frequency coupling is physiological or pathological. When pathological cross-frequency coupling is detected, neurostimulation of one or more sites is applied. In some embodiments, an implantable pulse generator is adapted to analyze neural activity for pathological cross-frequency coupling and to provide electrical stimulation in response to the detected pathological cross-frequency coupling.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: March 10, 2020
    Inventor: Dirk De Ridder
  • Patent number: 10576285
    Abstract: An example of a system for modulating blood pressure may include a blood pressure monitoring circuit, a blood pressure modulation device, and a control circuit. The blood pressure monitoring circuit may be configured to sense signals and generate one or more blood pressure parameters indicative of the blood pressure and/or a vascular resistance and one or more activity parameters indicative of an activity level and/or a postural change using the sensed signals. The blood pressure modulation device may be configured to deliver a therapy modulating the blood pressure. The control circuit may be configured to control the therapy using therapy parameters, receive the one or more blood pressure parameters and the one or more activity parameters, analyze changes in the one or more blood pressure parameters that are correlated to changes in the one or more activity parameters, and adjust the therapy parameters using an outcome of the analysis.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: March 3, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Elizabeth Mary Annoni, Kyle Harish Srivastava, Craig Stolen, Pramodsingh Hirasingh Thakur, Bradley Lawrence Hershey, Stephen B. Ruble, William Conrad Stoffregen, Bryan Allen Clark
  • Patent number: 10549097
    Abstract: A system may include electrodes on at least one lead configured to be operationally positioned for use in modulating a volume of neural tissue, a neural modulation generator configured to deliver energy using at least some electrodes to modulate the volume of neural tissue, a programming system configured to program the programmed modulation parameter set, including determine electrode fractionalizations for the electrodes based on a target multipole. The programmed parameter set may include the determined electrode fractionalizations. The target multipole may be used to determine electrode fractionalizations having at least three target poles that directionally and progressively stack fractionalizations of target poles to provide a linear electric field over the volume of tissue. The neural modulation generator may be configured to use the programmed modulation parameter set to provide the linear electric field over the volume of tissue.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: February 4, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Tianhe Zhang, Que T. Doan
  • Patent number: 10543359
    Abstract: A medical system implements a seizure detection algorithm to detect a seizure based on a first patient parameter. The medical system monitors a second patient parameter to adjust the seizure detection algorithm. In some examples, the medical system determines whether a seizure for which therapy delivery is desirable occurred based on a second patient parameter. If a target seizure occurred, and the seizure detection algorithm did not detect the target seizure, the medical system adjusts the seizure detection algorithm to detect the target seizure. For example, the medical system may determine a first patient parameter characteristic indicative of the target seizure detected based on the second patient parameter and store the first patient parameter characteristic as part of the seizure detection algorithm. In some examples, the first patient parameter is an electrical brain signal and the second patient parameter is patient activity (e.g., patient motion or posture).
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: January 28, 2020
    Assignee: Medtronic, Inc.
    Inventors: Jonathon E. Giftakis, Nathan A. Torgerson
  • Patent number: 10543367
    Abstract: The invention provides transcranial electrostimulation by combining transcranial direct current stimulation (tDCS) and theta burst stimulation (TBS) to achieve an unexpected therapeutic effect in various brain or neural diseases. Accordingly, the invention provides a mode of direct current with biphasic square wave pulses in the treatment of brain or neural diseases. Also provided are methods of employing the transcranial electrostimulation of the invention and applications of the transcranial electrostimulation of the invention.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: January 28, 2020
    Assignees: TAIPEI MEDICAL UNIVERSITY, NATIONAL APPLIED RESEARCH LABORATORIES
    Inventors: Chih-Wei Peng, Shih-Ching Chen, Yu Ting Li, Hsiang Ching Lee, Jia-Jin J. Chen, Tsung-Hsun Hsieh, Chien-Hung Lai, Jiunn-Horng Kang
  • Patent number: 10543362
    Abstract: A method and system of providing therapy to a patient using electrodes implanted adjacent tissue. The method comprises regulating a first voltage at an anode of the electrodes relative to the tissue, regulating a second voltage at a cathode of the electrodes relative to the tissue, and conveying electrical stimulation energy between the anode at the first voltage and the cathode at the second voltage, thereby stimulating the neural tissue. The system comprises a grounding electrode configured for being placed in contact with the tissue, electrical terminals configured for being respectively coupled to the electrodes, a first regulator configured for being electrically coupled between an anode of the electrodes and the grounding electrode, a second regulator configured for being electrically coupled between an anode of the electrodes and the grounding electrode, and control circuitry configured for controlling the regulators to convey electrical stimulation energy between the anode and cathode.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: January 28, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: David K. L. Peterson
  • Patent number: 10545217
    Abstract: Systems and methods for beacon device fleet management are provided. One example system includes a plurality of beacon devices, a plurality of mobile computing devices, a fleet management system, and a fleet owner computing devices. One example method includes receiving, by the fleet management system, a device status request from the fleet owner computing device. The fleet management system determines one or more operational statuses of beacon devices owned by the fleet owner and transmits data indicative of the one or more operational statuses to the fleet owner computing device. The operational statuses can include a current detection status (e.g., online or offline), a location status, a power source status, and/or other operational parameters.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: January 28, 2020
    Assignee: Google LLC
    Inventors: Mark William Weaver, Peter Sasaki, Jonathan Robert Morace, Salvatore Scellato
  • Patent number: 10542355
    Abstract: A hearing aid system includes an electric audio signal input, an audio input signal processing unit that is configured to process electric audio input signals in the first processing mode or in the second processing mode and to provide an electric audio output signal, and an output transducer. The hearing aid system further includes an audio input signal analysing unit that is configured to continuously monitor the electric audio input signal as a function of time and to determine and to provide a number of audio signal values each representing a characteristic of the electric audio input signal at a given time instance. The hearing aid system further includes a plurality of electrodes that are configured to be brought into contact with the skin of a user and which are configured—when operationally mounted to receive an electric signal that rep-resents a user's brain activity and to provide a respective EEG-related signal.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: January 21, 2020
    Assignee: OTICON A/S
    Inventors: Eline Borch Petersen, Thomas Lunner, Thomas Gleerup
  • Patent number: 10535427
    Abstract: Devices, systems, and methods pertain to planning and providing guidance for a cranial based implantation of an implantable medical device or devices. The collection of data, such as data pertaining to the skull of the patient, the scalp of the patient, the vascular structure or neurological structures in the head of the patient, is performed. The data may be in the form of images, such as images generated by X-ray, magnetic resonance imaging, CT-scan and fluoroscopy. A surgeon can use the collected data to determine, for example, whether the patient is a candidate for a cranial implantation, whether the patient's skull and scalp can support the implantation, what configuration of device should be implanted, where the device should be implanted, and how the surgical incisions should be made.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: January 14, 2020
    Assignee: Medtronic, Inc.
    Inventor: Steven M. Goetz
  • Patent number: 10525267
    Abstract: The present disclosure relates generally to systems, methods, and devices for closed loop deep brain stimulation. In particular, a neural signal is measured and provided to software. The software includes a feature generator and a brain network model that takes the neural signal and estimates other neural signals that are not directly measured, and operates as a model of the brain. The software determines a stimulation signal to be sent to stimulating electrodes. Estimated signals by the brain network model are continuously compared to actual signals from the brain. The closed loop feedback system advantageously allows for electrical stimulation levels and patterns to be continuously updated while delivered to a patient.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: January 7, 2020
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Chad E. Bouton, Gaurav Sharma, Bradley C. Glenn
  • Patent number: 10512413
    Abstract: A method for identifying and treating a neural pathway associated with chronic pain via nerve stimulation and brain wave monitoring of a mammalian brain includes positioning a probe to stimulate a target nerve, wherein the target nerve is suspected of being a source of chronic pain; delivering a first nerve stimulation from the probe to the target nerve, wherein the first nerve stimulation is sufficient to elicit a chronic pain response in the brain; and monitoring for evoked potential activity in the brain as a result of the first nerve stimulation. The method can also include delivering second and third nerve stimulations to confirm the correct identification of the neural pathway and to treat the chronic pain, respectively. A system and apparatus for performing a procedure to identify and treat a nerve that is the source of chronic pain are also described.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: December 24, 2019
    Assignee: Avent, Inc.
    Inventors: Eric A. Schepis, Phillip A. Schorr, Joshua D. White
  • Patent number: 10507335
    Abstract: The present disclosure relates to the field of medical technology and in particular to the field of transcranial magnetic stimulation. A coil assembly is presented comprising a housing; a magnetic coil, and an electrode arrangement; wherein the magnetic coil is arranged in the housing and is adapted for generating a magnetic field for transcranial magnetic stimulation, wherein the electrode arrangement is arranged on the housing and adapted for deriving an EEG signal, and wherein the magnetic coil and the electrode arrangement are arranged on top of each other. Further, an electrode arrangement and a system for transcranial magnetic stimulation are provided.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: December 17, 2019
    Assignee: EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINIZCHE FAKULTAET GESCHWISTER-SCHOLL-PLATZ
    Inventors: Christoph Zrenner, Ulf Ziemann
  • Patent number: 10507324
    Abstract: A system for individualizing neuromodulation includes a neurostimulation device having a set of electrodes, and an application executing on a user device. Additionally or alternatively, the system can include any or all of: a sensor system, a head-securing mechanism, a remote server, storage, an accessory device, and any other suitable component. A method for individualizing neuromodulation includes determining a task of interest to a user; determining a user skill level associated with the task; determining a set of goals; determining an individualized neuromodulation program comprising a neurostimulation pattern; and delivering the neurostimulation pattern to the user. Additionally or alternatively, the method can include any or all of: determining user progress; displaying user progress; receiving user feedback; determining and/or adapting neuromodulation program based on user progress and/or user feedback; and any other suitable process.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: December 17, 2019
    Assignee: Halo Neuro, Inc.
    Inventors: Brett Wingeier, Randall Lin, Daniel Toker
  • Patent number: 10500398
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level. Between titration sessions one or more parameters, such as, for example, an acclimation interval, may be adjusted based on the patient's response to the stimulation. This personalized titration process can minimize the amount of time required to complete titration so as to begin delivery of the stimulation at therapeutically desirable levels.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: December 10, 2019
    Assignee: LivaNova USA, Inc.
    Inventors: Imad Libbus, Bruce H. KenKnight, Badri Amurthur, Scott R. Stubbs
  • Patent number: 10485465
    Abstract: A pulse oximetry device includes a light emission device configured to emit light with a wavelength in a first wavelength interval and light with a wavelength in a second wavelength interval, a first light detector configured to detect light with a wavelength in the first wavelength interval, but not to respond to light with a wavelength in the second wavelength interval, and a second light detector configured to detect light with a wavelength in the first wavelength interval and detect light with a wavelength in the second wavelength interval, wherein the first light detector has a first light reception surface, the second light detector has a second light reception surface, and the first light reception surface and the second light reception surface are arranged in a common plane and are interleaved with one another.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: November 26, 2019
    Assignee: OSRAM Opto Semiconductors GmbH
    Inventors: Hubert Halbritter, Michael Klein, David O'Brien
  • Patent number: 10470680
    Abstract: Systems and methods are provided for controlling an entity in response to activity in a peripheral nerve comprising a plurality of fascicles. A multicontact electrode assembly is configured to record activity from the peripheral nerve. A processing component includes a sensor mapping component configured to quantify activity associated with a proper subset of the plurality of fascicles, an evaluation component configured to determine an adjustment of the status of the controlled entity from the quantified activity of the proper subset of the plurality of fascicles, and a controller configured to provide a control signal, representing the adjustment of the status of the controlled entity, to the controlled entity.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: November 12, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Dominique M. Durand, Brian Wodlinger
  • Patent number: 10463572
    Abstract: The application is directed to a vial adapter for attaching a medicament vial to a medicament delivery device having a reservoir adapted to receive and contain the medicament. The vial adapter can include a housing with two ports (one for attaching the reservoir and the other for attaching to the vial), a hollow needle that pierces septums sealing each of the reservoir and the vial, and a floating part that fixedly holds the hollow needle. Clearance between the floating part and the housing can enable relative movement of the floating part.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: November 5, 2019
    Assignee: NeuroDerm, Ltd.
    Inventors: Eran Shor, Tsabar Mor, Tamir Ben David, Nir Lilach, Rami Grossfeld, Shai Alfandari, Ram Nadler, Dmitry Golom, Daniel Shaki, Yoav Tikochinsky, Serdar Ozsumer
  • Patent number: 10463860
    Abstract: A method of monitoring neural activity responsive to a stimulus in a brain, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: November 5, 2019
    Assignee: THE BIONICS INSTITUTE OF AUSTRALIA
    Inventors: Nicholas Sinclair, Hugh Mcdermott, James Fallon, Thushara Perera, Arthur Wesley Thevathasan, Kristian Bulluss
  • Patent number: 10456581
    Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a single pass implantable lead configured to be coupled to the implantable medical device and arranged to sense and pace the chambers of a patient's heart. The lead may include a proximal region having a plurality of electrodes, a distal region having at least one electrode, and an intermediate region therebetween. The system can sense and pace the right atrium, the left atrium, the right ventricle, and the left ventricle.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: October 29, 2019
    Assignee: Cardiac Pacemakers, Inc
    Inventors: Lili Liu, Matthew J. Miller, Kyle K. Hoecke, Ronald W. Kunkel
  • Patent number: 10449374
    Abstract: An electrostimulator implant comprises (i) an implant body, the implant being injectable into tissue of a subject along a longitudinal axis of the implant body, (ii) first and second electrodes, disposed on respective first and second portions of the implant body; (iii) circuitry, disposed inside the implant body, and configured to drive the electrodes to apply current to the tissue; and (iv) a mesh. The mesh is configured to serve as an anchor of the implant, is disposed over a third portion of the implant body that is longitudinally between the first and second portions of the implant body, and has a first end and a second end. Each of the ends is fixedly attached to respective first and second sites of the implant body, the respective sites being longitudinally between the first and second electrodes.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: October 22, 2019
    Assignee: BLUEWIND MEDICAL LTD.
    Inventors: Gur Oron, Eran Benjamin, Bar Eytan, Nir Armoni, Yossi Gross
  • Patent number: 10441207
    Abstract: A configurable system is used to evaluate stimulus sensitivity of a subject. An action channel provides a stimulus to the subject and a reaction channel receives a response from the subject. A signal pathway is connected to the action channel and to the reaction channel. A controller establishes loops within the signal pathway. Loop types include a transduction loop including the action channel and forming a path terminating in the signal pathway, and a channel loop including the action channel and terminating at a reference unit. Other possible loop types include an interface loop including the action channel, the reaction channel and the reference unit having an initial parameter value, and an adaptive loop including the action channel, the reaction channel and the reference unit whose parameter value is adapted based on the response from the subject. A method using the system is also described.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: October 15, 2019
    Assignee: COGNISENS INC.
    Inventors: Jocelyn Faubert, Rafael Doti, Jesus-Eduardo Lugo-Arce
  • Patent number: 10434310
    Abstract: A conductive implantable stimulation device for implantation at the head of a subject to treat a neurological disease, comprising a first passive conductive member, wherein the first member is sized and configured for being implanted under the skull bone of the patient, and wherein the first member comprises a conductive interface adapted for extracranial stimulation.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: October 8, 2019
    Assignee: Sooma Ltd.
    Inventors: Tuomas Neuvonen, Jani Virtanen, Mika Nikader
  • Patent number: 10434300
    Abstract: Devices and circuits for reducing sizes of medical devices are disclosed. In one example, an implantable medical device (IMD) may include a housing, multiple electrodes outside of the housing, an energy storage device within the housing, and a circuit within the housing and connected to the energy storage device and the two or more electrodes. In some cases, the circuit may include two or more island sections, with each island section connected to at least one other island section by a ribbon section. Each island section may have two opposing major surfaces. A first island section and a second island section may be stacked within the housing such that one of the two major surfaces of the first island section faces one of the two opposing major surfaces of the second island section.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: October 8, 2019
    Assignee: Cardiac Pacemaker, Inc.
    Inventors: Keith R. Maile, John M. Edgell, Mathew L. Gilk, Brian L. Schmidt, Benjamin J. Haasl, James E. Blood