Treating Mental Or Emotional Disorder Patents (Class 607/45)
  • Patent number: 11452666
    Abstract: A method for treatment of a headache disorder in a human subject, including selecting at least one treatment area in the nasal cavity of the human subject, said treatment area being selected from a posterior part of the nasal cavity or an anterior part of the nasal cavity, providing a device including a stimulation member arranged for vibration stimulation of the selected treatment area, and at least one expansion member provided with a channel having a plurality of openings arranged for fluid communication with the stimulation member, introducing the stimulation member into a nasal cavity of the human subject, expanding the stimulation member to a volume such that the stimulation member abuts against the tissue to exert a pressure on tissue of the selected treatment area and bringing the stimulation member to vibrate in the nasal cavity to impart vibrations to the selected treatment area, wherein the vibrations are imparted to a posterior part of the nasal cavity, to an anterior part of the nasal cavity, seq
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: September 27, 2022
    Assignee: CHORDATE MEDICAL AB
    Inventors: Jan-Erik Juto, William Holm, Fredrik Juto
  • Patent number: 11432760
    Abstract: Systems and methods for remote therapy and patient monitoring are provided. A method comprises contacting an outer skin surface of a patient with a contact surface of a stimulator and transmitting an electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. Data related to parameters of the electrical impulse applied to the nerve is stored and transmitted to a remote source. The data may include duration of treatment, amplitude of the electrical impulse, compliance with a prescribed therapy regimen or other relevant data related to the therapy. The method may further include collecting patient status data, such as symptoms of a medical condition (e.g., severity of a headache) before, during and/or after stimulation. The patient status data is correlated with the treatment data to monitor compliance and/or the effectiveness of the therapy.
    Type: Grant
    Filed: October 29, 2021
    Date of Patent: September 6, 2022
    Assignee: ELECTROCORE, INC.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Patent number: 11420062
    Abstract: The present disclosure relates to a neuromodulation and/or neurostimulation system comprising at least the following components: at least one sensing unit, at least control unit, at least one stimulation unit, at least one Central Nervous System (CNS) stimulation module, at least one Peripheral Nervous System (PNS) stimulation module, wherein at least one of the components of the neuromodulation and/or neurostimulation system is implantable.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: August 23, 2022
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Sophie Wurth, Grégoire Courtine, Silvestro Micera
  • Patent number: 11406833
    Abstract: An implanted stimulator can deliver a patient-detectable electrical stimulation to remind or prompt a patient to interact with an implanted therapeutic device (e.g., neurostimulator) when a prompting event occurs. For example, the apparatuses and methods described herein may be configured to apply a prompting patient-detectable electrical vagus nerve stimulation to remind a patient that it is time to administer a therapeutic dose. When the therapeutic device is operated in an automatic fashion, the apparatus can also deliver a patient-detectable warning stimulation prior to the therapeutic stimulation to let the patient know that a therapeutic stimulation will be delivered soon thereafter.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: August 9, 2022
    Assignee: SetPoint Medical Corporation
    Inventors: Michael A. Faltys, Jacob Arial Levine, Richard A. Block
  • Patent number: 11406824
    Abstract: Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: August 9, 2022
    Assignee: NeuroPace, Inc.
    Inventors: Brett Wingeier, Daniel Chao, Benjamin Pless, Thomas Tcheng
  • Patent number: 11406825
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat neurodegenerative diseases, such as dementia, Alzheimer's disease, ischemic stroke, post-concussion syndrome, chronic traumatic encephalopathy and the like by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: August 9, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Patent number: 11410351
    Abstract: Embodiments of the present disclosure may disclose a method for improving CT image quality. The method for improving the CT image quality may include obtaining SFS data. The SFS data may include SFS scan data or an SFS image. The SFS scan data may be acquired by a CT device in an SFS state. The SFS image may be generated by reconstructing scan data acquired by the CT device via scanning in the SFS state. The method may include generating a corresponding optimized image by processing the SFS data based on an image quality optimization model. The image quality optimization model may be a machine learning model. The present disclosure may simulate the SFS image as an FFS image using a deep neural network model, thereby improving a resolution of the SFS image and reduce artifacts in the SFS image.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: August 9, 2022
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Yuan Bao, Guotao Quan, Rengcai Yang
  • Patent number: 11400288
    Abstract: A method for modulating a nerve within a body of a patient includes generating a single signal comprising an electrical impulse, contacting an interface with an outer skin surface of a patient and delivering the electrical impulse from an electrode through the interface and the outer skin surface of the patient to a vagus nerve, thereby modulating the vagus nerve. The electrical impulse may comprise bursts of pulses with a silent intra-burst interval between each of the bursts based on the single signal, wherein each of the bursts has a frequency of about 5 Hz to about 100 Hz and each of the pulses has a duration from about 50 microseconds to about 1000 microseconds. The electrode may be spaced from the interface by a distance of about 0.25 to about 4 times an outer dimension of the interface.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: August 2, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 11400292
    Abstract: A method of using deep brain stimulation (DBS) for treating mental disorders associated with high connectivity in brain circuits, such as cortico-striato-thalamo-cortical (CSTC) circuits, is provided. The method comprises providing a first electrical signal having a first frequency to a first electrode implanted at a first location within a brain circuit and providing a second electrical signal having a second frequency to a second electrode implanted at a second location within the brain circuit. The first frequency and the second frequency are unequal.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: August 2, 2022
    Inventors: Emad N. Eskandar, Alik S. Widge, Darin D. Dougherty
  • Patent number: 11399773
    Abstract: Time-efficient identification of a brain network input-output (IO) dynamics model for brain stimulation includes generating an input stochastic-switched noise-modulated waveform characterized by at least one parameter modulated according to a stochastic-switched noise sequence, inputting the input stochastic-switched noise-modulated waveform to a clinical brain-response system, recording one or more time-correlated outputs of the clinical brain-response system responsive to the input stochastic-switched noise-modulated waveform, and identifying a brain network IO dynamics model that optimally correlates the input stochastic-switched noise-modulated waveform to the one or more time-delimited outputs of the clinical brain-response system. A desired brain response to an input electrical signal may be obtained using the model, such as by modulating the input electrical signal using a closed-loop control algorithm based on the brain network IO dynamics model.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: August 2, 2022
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventor: Maryam Shanechi
  • Patent number: 11389650
    Abstract: A method for treating chronic nociceptive pain of knee osteoarthritis comprising the steps of: placing a first set of electrodes in contact with the skin on the inner side of the knee on the path of the infrapatellar nerve; and generating a first electrical signal with a signal generator and applying said first signal to the first set of electrodes so as to produce external, i.e. non invasive, electrostimulation of the infrapatellar nerve of the knee.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: July 19, 2022
    Assignee: SUBLIMED
    Inventors: Sandrine Thomas-Soriot, Patricia Abraham-Briffod, Florent Le Bastard
  • Patent number: 11389661
    Abstract: The present invention involves methods and systems for treatment of brain disorders using neuromodulation of brain networks. Implantation occurs by selecting sites which modulate the network in selected manners, or are modulated by a stimulus in a particular manner that is relevant to treatment of the network. The candidate locations within a brain region are evaluated in relation to how these are indirectly modulated by stimulation at a different brain region. Treatment of one or more brain networks associated with a brain disorder is realized with a consideration of network dynamics and coupling effects such as indirect stimulation of non-target regions. A brain modulation system (BMS) increases, decreases, or otherwise modulates network regional activity in a differential manner. Therapy and electrode locations are adjusted using sensed data and target implantation criteria related to the brain network model.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: July 19, 2022
    Inventor: Michael Sasha John
  • Patent number: 11389655
    Abstract: Systems and techniques are disclosed to adjust programming of an implantable electrical neurostimulation device for treating chronic pain of a human subject, through the use of a dynamic model adapted to identify pain treatment parameters for a human patient and determine a best device operational program to implement the pain treatment parameters to address the chronic pain condition. In an example, the system to adjust programming of the neurostimulation device performs operations that: obtain data related to a state of pain of the human subject; identify pain treatment parameters using a dynamic model adapted to evaluate the pain treatment parameters in the human subject over a time period, based on the data related to the state of pain; and select a neurostimulation program for the neurostimulation device, corresponding to at least a portion of the identified pain treatment parameters.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: July 19, 2022
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Qinghuang Lin, Jeffrey Rogers, Giovanni Russo, Andrea Simonetto, Tigran Tchrakian
  • Patent number: 11389646
    Abstract: Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent symptoms of headache in a patient. The headache may include primary headache, such as migraine and cluster headache, or secondary headache resulting from an underlying medical condition, such as post-concussion headache. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm that includes single doses of between about 30 seconds to about 5 minutes. The electrical impulses may have a frequency of about 1 kHz to about 20 kHz.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: July 19, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Patent number: 11383081
    Abstract: A neurostimulation system includes an electromyographic (EMG) electrode; a neural electrode implantable in a deep cerebellar nuclei of a subject; a data acquisition unit in communication with the EMG electrode for receiving and transmitting a EMG signal; and a processor in communication with the data acquisition unit, the processor generates a EMG pattern based on the EMG signal and outputs a stimulation signal to the neural electrode when the EMG pattern is indicative of an abnormal motor movement. A method of modulating an abnormal motor movement of a subject by using the neurostimulation system.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: July 12, 2022
    Assignee: City University of Hong Kong
    Inventors: Chi Him Eddie Ma, Chung Tin, Gajendra Kumar
  • Patent number: 11376434
    Abstract: Devices, systems, and techniques are configured for identifying stimulation parameter values based on electrical stimulation that induces dyskinesia for the patient. For example, a method may include controlling, by processing circuitry, a medical device to deliver electrical stimulation to a portion of a brain of a patient, receiving, by the processing circuitry, information representative of an electrical signal sensed from the brain after delivery of the electrical stimulation, determining, by the processing circuitry and from the information representative of the electrical signal, a peak in a spectral power of the electrical signal at a second frequency lower than a first frequency of the electrical stimulation, and responsive to determining the peak in the spectral power of the electrical signal at the second frequency, performing, by the processing circuitry, an action.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: July 5, 2022
    Assignee: Medtronic, Inc.
    Inventors: Rene A. Molina, Scott R. Stanslaski, Jadin C. Jackson, Christopher L. Pulliam, Eric J. Panken, Michelle A. Case, Abbey Beuning Holt Becker
  • Patent number: 11376437
    Abstract: Some embodiments relate to a method of adjusting therapeutic stimulation from a therapeutic stimulation system. The method comprising: providing therapeutic stimulation based on a plurality of stimulation parameters to a patient with an implanted controller and at least two electrodes; receiving data indicative of feedback associated with a patient rating of the therapeutic stimulation via a patient input device; automatically adjusting, with the implanted controller, at least one of the plurality of stimulation parameters; and providing adjusted therapeutic stimulation based on the adjusted at least one stimulation parameter to the patient with the controller and the at least two electrodes.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: July 5, 2022
    Assignee: DEEP BRAIN STIMULATION TECHNOLOGIES PTY LTD
    Inventor: Hugh McDermott
  • Patent number: 11369795
    Abstract: A medical device is configured to deliver a series of electrical stimulation pulses including opposing polarity pulses. The medical device delivers a charge balancing pulse by modifying every nth pulse of the electrical stimulation pulses to reduce a net charge delivered over the series of electrical stimulation pulses. In some examples, the medical device may be an implantable medical device that is coupled to an extra-cardiovascular lead for delivering the cardiac pacing pulses.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: June 28, 2022
    Assignee: Medtronic, Inc.
    Inventors: Eric D. Corndorf, Robert T. Sawchuk
  • Patent number: 11369801
    Abstract: Devices, systems, and techniques are described for use in recharging a power source of a cranially mounted implantable medical device. In one example, a wearable medical device includes a flexible body configured to cover at least a portion of a scalp of a head of a patient. A securing member is connected to the flexible body and configured to extend around a circumference of the head to stabilize the flexible body with respect to the scalp of the patient. A fixation member is configured to mount to a location of the flexible body and couple the flexible body to a recharge coil that is configured to recharge the power source of the cranially-mountable implantable medical device.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: June 28, 2022
    Assignee: Medtronic, Inc.
    Inventors: Shahram Malekkhosravi, Venkat R. Gaddam, Rebecca J. S. Haag, Eric R. Schleppenbach, Brendan J. Young-Dixon, Marshall S. Comisar, Zane K. Thimmesch-Gill, Brent P. Johnson
  • Patent number: 11369787
    Abstract: The invention, in one aspect, relates to an intravascular electrode system. The system comprises one or more electrodes supported on an elongated resiliently flexible support member, and the support member may be used to introduce the electrodes into a blood vessel. As the support member is introduced into the blood vessel the support member bends to follow the path of the blood vessel.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: June 28, 2022
    Assignee: Lungpacer Medical Inc.
    Inventors: Joaquin Andres Hoffer, Marc-Andre Nolette, Viral Thakkar, Bao Dung Tran
  • Patent number: 11357969
    Abstract: Methods, systems, and devices for implantable node are described. The method may include storing, at an implantable stimulation node, a set of stimulation profiles in a memory during a configuration phase. The method may also include receiving a stimulation command corresponding to a stimulation profile of the set of stimulation profiles during a treatment phase. The method may further include delivering stimulation based at least in part on the stimulation profile corresponding to the received stimulation command. In some cases, the system may include an implantable hub, an implantable sensing node, and a sensing device.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: June 14, 2022
    Assignee: Medtronic, Inc.
    Inventors: Erik J. Peterson, Mandla Thokozani Shongwe, Earle Timothy Roberts, David Andrew Dinsmoor
  • Patent number: 11357980
    Abstract: Apparatus and methods are described including placing a set of two or more electrodes (22) in electrical contact with a portion of a subject's body. At least one computer processor (24) drives the electrodes to apply an amplitude shift keying signal to the portion of the subject's body, the amplitude shift keying signal containing a high frequency component that acts as a carrier wave, the high frequency component having a frequency of between 80 Hz and 120 Hz, and a low frequency component that acts as a modulating component that modulates the carrier wave, the low frequency component having a frequency of between 1 Hz and 8 Hz. Other applications are also described.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: June 14, 2022
    Assignee: THERANICA BIO-ELECTRONICS LTD.
    Inventors: Alon Ironi, Ronen Jashek
  • Patent number: 11357444
    Abstract: Systems, methods and computer-readable media are provided for identifying persons who are likely to benefit from a neurosurgical procedure, such as lobectomy, hemispherectomy, lesionectomy, callosotomy, and the like. Measured values of physiological variables may be combined via a multi-variable predictive model. In some embodiments, this may take the form of a multinomial logistic regression classifier. In other embodiments, the evidence-combining may be implemented via a neural network or support vector machine or similar machine learning or classification methods. In an embodiment, a leading indicator of near-term responsiveness to the regimen may be provided to a caregiver, such as a neurologist, and further may be integrated with case-management software and an electronic health record decision-support system.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: June 14, 2022
    Assignee: CERNER INNOVATION, INC.
    Inventor: Douglas S. McNair
  • Patent number: 11351379
    Abstract: A method for controlling synchrony in a plurality of brain regions of a subject includes receiving signals from a source region of the subject's brain, determining at least one phase of the signals from the source region in a predetermined frequency band and delivering at least one stimulation pulse to at least one target region of the subjects brain based on the at least one phase of the signals from the source region to synchronize oscillations of the source region and the at least one target region.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: June 7, 2022
    Assignee: The General Hospital Corporation
    Inventors: Alik S. Widge, Meng-Chen Lo, Ethan Blackwood
  • Patent number: 11351378
    Abstract: The present invention relates to methods that enable one to design temporal patterns for the optimal stimulation of a nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention relates to methods to design improved stimulation patterns and/or genetic algorithms for the optimal stimulation of a nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention utilizes a model-based design to achieve a more optimal stimulation pattern for use in connection with a nervous system, one or more nerve cells, or nervous tissue (e.g., a human nervous system). In another embodiment, the model-based design of the present invention utilizes a systematic search method to identify parameters (e.g., design variables) that minimize a cost function (e.g., optimize the fitness of a particular design).
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: June 7, 2022
    Assignee: DUKE UNIVERSITY
    Inventors: Warren M. Grill, David T. Brocker, Alexander R. Kent
  • Patent number: 11351362
    Abstract: A kit for transcranial brain stimulation is disclosed. The kit comprises a headset for transcranial brain stimulation, and a non-transitory computer-readable recording medium having recorded thereon a program which is executable on an electronic device having processing capabilities. The program comprises program code portions which when executed on the electronic device is configured to: store, in a computer memory, a schedule for performing the transcranial brain stimulation; and generate a control signal for the headset such that transcranial brain stimulation is performed according to the schedule for performing the transcranial brain stimulation. The headset comprises: a wireless transceiver configured to wirelessly communicate with the electronic device; a circuit comprising a first electrode, a second electrode and a power source configured to provide power to the circuit; and a controller being configured to control powering of the circuit according to the control signal.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: June 7, 2022
    Assignee: FLOW NEUROSCIENCE AB
    Inventors: Daniel Månsson, Erik Rehn
  • Patent number: 11344732
    Abstract: A system may comprise a controller configured to implement an algorithm on a received input to produce an output, and a system input operably connected to the controller and configured for use to enter at least one input into the algorithm. The at least one input may include: one or more sensor inputs or one or more inputs from smart appliances or one or more user inputs regarding at least one of time of day or mental or physical state; or at least one of a user-inputted disease, a user-inputted disease state, or a user-inputted symptom-related information into the algorithm. The controller may be configured to provide instructions through the system output to implement a system action. The algorithm implemented by the controller may be configured to identify one, or a combination of more than one, of the neuromodulation modes as a candidate neuromodulation mode based on the input(s).
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: May 31, 2022
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Michael A. Moffitt, Sridhar Kothandaraman, Chirag Shah, Vikrant Venkateshwar Gunna Srinivasan, Richard Mustakos
  • Patent number: 11338144
    Abstract: A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: May 24, 2022
    Assignee: ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventor: Edward K. F. Lee
  • Patent number: 11338129
    Abstract: Methods of providing electrical neural modulation to a patient's brain are disclosed herein. The methods involve differentially modulating two or more target regions of the brain. For example, a first target region may be provided with an electrical neural modulation signal that activates that target region while a second target region is provided with an electrical neural modulation signal that suppresses or deactivates that target region. As the implantable pulse generators (IPGs) described herein include independent current sources, such differential modulation can be provided with a single IPG.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: May 24, 2022
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Hemant Bokil
  • Patent number: 11338136
    Abstract: A cranial nerve control device includes: goggles worn on a patient head; a functional electric stimulator adapted to apply peripheral nerve stimulation to a patient; a plurality of module guides provided to the goggles; a functional electric stimulator controller adapted to control the functional electric stimulator; a transcranial current stimulator-combined near-infrared spectroscopy measurement module controller adapted to control the transcranial current stimulator-combined functional near-infrared spectroscopy measurement module; and a simulation device connected to both the transcranial current stimulator-combined near-infrared spectroscopy measurement module controller and the functional electric stimulator to provide feedback of a transcranial current stimulation control signal to the transcranial current stimulator and feedback of a functional electrical stimulation control signal to the functional electric stimulator while monitoring the patient brain activity.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: May 24, 2022
    Assignee: CYBERMEDIC CO., LTD.
    Inventors: Ho Choon Jeong, Hyun Hee Lee, Sang Sea Lee, Myoung Choon Kim
  • Patent number: 11331474
    Abstract: A low-profile intercranial device adapted for housing a functional neurosurgical implant in manner providing for convenient and reliable grounding to ensure proper impedance measurements includes a static cranial implant including a base cranial implant member including an outer first surface, an inner second surface, and a recess shaped and dimensioned for receiving a functional neurosurgical implant. The low-profile intercranial device includes a plurality of fluid passageways extending between the inner second surface and the recess allowing for the flow of bodily fluid between an external environment of the base cranial implant member and a cavity defined by the recess.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: May 17, 2022
    Assignee: LONGEVITI NEURO SOLUTIONS LLC
    Inventors: Bradley Rabinovitz, Corbin Clawson, Jimmy Shah
  • Patent number: 11331483
    Abstract: Described is a system for automatic adjustment of neurostimulation. The system controls stimulation of specific neural regions through a neural device positioned on a human subject, while simultaneously performing recordings from the neural device using a targeted arrangement of stimulating electrodes and distinct types of recording electrodes of the neural device. Stimulation of the specific neural regions is adjusted in real-time based on the recordings from the neural device.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: May 17, 2022
    Assignee: HRL Laboratories, LLC
    Inventors: Matthias Ziegler, Jaehoon Choe, Matthew E. Phillips
  • Patent number: 11331510
    Abstract: A device for magnetic field stimulation of a user's body tissue, is provided which includes an adjustable seating arrangement for the user, at least one magnetic field applicator for generating a pulsating magnetic field in the area of the seating arrangement, control panel for setting one or several parameters of the pulsating magnetic field comprising pulse duration, pulse frequency and pulse amplitude, and/or for adjusting the seating arrangement, and display screen for displaying information. The control panel are designed to manually and/or automatically adjust one or more of the parameters of the magnetic field and/or to adjust the seating arrangement as a function of previously recorded individual information about the user.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: May 17, 2022
    Assignee: PROF. DR. FISCHER AG
    Inventor: Gerhard Fischer
  • Patent number: 11324427
    Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: May 10, 2022
    Assignee: Saluda Medical Pty Ltd
    Inventors: John Louis Parker, Peter Scott Vallack Single, Dean Michael Karantonis
  • Patent number: 11324915
    Abstract: Aspects include a method, system and computer program product for alleviating an episode of a movement disorder condition for a patient. The method comprises deploying an unmanned aerial vehicle (UAV) to a location of a patient based on an occurrence of an episode of a movement disorder condition. A first gross sensory change stimulus is selected with a processor. The first gross sensory change stimulus is projected from the UAV. An attempt to alleviate the episode of the movement disorder condition is performed based at least in part on the projecting of the first gross sensory change stimulus from the UAV. The alleviating of the episode of the movement disorder condition is detected based on the gross sensory change stimulus from the UAV.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: May 10, 2022
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: James R. Kozloski, Clifford A. Pickover, John J. Rice
  • Patent number: 11324916
    Abstract: A wearable device and method for multimodal stimulation of the vagus nerve having a pair of ear pieces, which are placed at least partially within the concha of an individual. Each ear piece has at least on electric stimulator which provides electric current to the ear of the individual. The wearable device also has a connection which provides stimulation instructions to the stimulators. The method for multimodal simulation also includes iterative biometric measurement and stimulation.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: May 10, 2022
    Assignee: Vagus Health Ltd.
    Inventor: Gustaf Kranck
  • Patent number: 11324963
    Abstract: Provided herein are, for example, systems and methods of diagnosing and treating depression, in which a transcranial magnetic stimulation (TMS) therapy is administered to a subject in need thereof and measuring a TMS evoked response in the subject, are provided. The systems and methods allow tailoring or optimizing of a treatment protocol for maximal individual benefit, thereby providing an individualized and optimized treatment protocol for psychiatric disorders such as depression.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: May 10, 2022
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: Amit Etkin, Corey Keller, Wei Wu
  • Patent number: 11317869
    Abstract: An EEG headpiece includes an array of electrode pins, each electrode pin extending between a proximal end, formed by a proximal end face, and a distal end and including a conducting electrode and a thermoplastic material. The thermoplastic material is arranged at least around a periphery of the electrode pin or is pressable from a hollow space to the periphery. Each electrode pin is equipped for the transmission of energy, especially mechanical vibration energy, from the proximal end face to the thermoplastic material to liquefy at least portions of the thermoplastic material from a solid state to a flowable state, whereby the thermoplastic material is capable of flowing into structures of a tissue portion surrounding the periphery and of forming, after re-solidification of the thermoplastic material, an anchoring of the electrode pin in the tissue portion.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: May 3, 2022
    Assignee: WOODWELDING AG
    Inventors: Marcel Aeschlimann, Jörg Mayer, Mario Weiss, Aymeric Niederhauser
  • Patent number: 11315685
    Abstract: A method of building a machine learning pipeline for predicting the efficacy of anti-epilepsy drug treatment regimens is provided.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: April 26, 2022
    Assignee: UCB BIOPHARMA SRL
    Inventors: Kunal Malhotra, Sungtae An, Jimeng Sun, Myung Choi, Cynthia Dilley, Chris Clark, Joseph Robertson, Edward Han-Burgess
  • Patent number: 11311729
    Abstract: In some examples, a medical device is configured to deliver sub-threshold electrical stimulation therapy to a patient at a stimulation intensity that is significantly less than a perception or paresthesia threshold intensity level for the patient. The medical device may determine the particular intensity level for the patient through a titration process. The medical device may titrate automatically or based upon the input of the patient, a clinician or a physician.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: April 26, 2022
    Assignee: Medtronic, Inc.
    Inventors: Lachlan Davies, Sheryl McCammon, Andrew J. Cleland, Melanie D Goodman Keiser, Ye Tan, Lisa M. Johanek, Nathan A. Torgerson
  • Patent number: 11305121
    Abstract: We report a method of automatically titrating an electrical therapy administered to a patient by an implanted medical device to a target dosage, comprising programming the medical device with a programmed electrical therapy comprising a first target value for a first therapy parameter; programming at least one titration parameter for automatically adjusting the first therapy parameter from a first value to the first target value over a titration time period initiating the electrical therapy, wherein the first therapy parameter comprises said first value; and automatically titrating the electrical therapy by making a plurality of adjustments to the value of the first therapy parameter, whereby the first electrical therapy parameter is changed from the first value to the first target value according to a titration function. We also report a medical device system configured to implement the method.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: April 19, 2022
    Assignee: Flint Hills Scientific, LLC.
    Inventor: Ivan Osorio
  • Patent number: 11298070
    Abstract: A method for monitoring neural activity responsive to a stimulus in a brain, the method comprising: a. applying a first stimulus to one or more of at least one electrode implanted in the brain, the first stimulus comprising a first plurality of bursts of stimulation, b. detecting high frequency oscillations (HFOs) between about 200 Hz and about 500 Hz due to neuronal activity at one or more of the at least one electrode implanted in the brain at least partially during application of the first stimulus; c. determining one or more waveform characteristics of the HFOs; and d. generating a second stimulus comprising a second plurality of bursts of stimulation, wherein one or more waveform characteristics of the second stimulus is dependent on the one of more waveform characteristics of the HFOs; and e. applying the second stimulus to one or more of the at least one electrode implanted in the brain.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: April 12, 2022
    Assignee: DEEP BRAIN STIMULATION TECHNOLOGIES PTY LTD
    Inventors: Nicholas Sinclair, Hugh McDermott, James Fallon, Thushara Perera, Arthur Wesley Thevathasan, Kristian Bulluss
  • Patent number: 11298542
    Abstract: A brain mapping system and methods that allow to predict and monitor the risk of suicide and provide personalized therapy. The brain mapping system and methods detect if brain dysfunctions (injuries) are located in suicidal hubs that trigger increased suicidal ideation and high risk of suicide. The brain mapping technology is suited for different technologies and allows to monitor the effects of therapy, provide precise therapy to decrease the risk of suicide.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: April 12, 2022
    Assignee: AddBrain Inc
    Inventor: Dorian Aur
  • Patent number: 11298546
    Abstract: This present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for identifying optimized temporal patterns of spinal cord simulation (SCS) for minimizing variability in patient responses to SCS. The systems and methods of neuromodulation disclosed herein facilitate the treatment of neuropathic pain associated with various disease states and clinical indications.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: April 12, 2022
    Assignee: Duke University
    Inventors: Warren Grill, John Gilbert
  • Patent number: 11298527
    Abstract: An autonomous neurostimulation unit used in the modulation of the nervous system is provided and has: at least one pair of pads, each formed by at least one inner layer of ceramic; an intermediate layer; and a conductive alloy coating. The material of the layer of coating is different and has different conductivity in each of the pads of the pair. The unit can be used in the modulation of the nervous system, with neurostimulation methods that are adapted to each patient.
    Type: Grant
    Filed: July 4, 2018
    Date of Patent: April 12, 2022
    Inventor: Aitaro Seikai Armenta
  • Patent number: 11297445
    Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: April 5, 2022
    Assignee: ELECTROCORE, INC.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 11291832
    Abstract: Embodiments discussed herein facilitate identification of a target area within a region of a brain for stimulation via one or more BS (Brain Stimulation) electrodes. One example embodiment comprises generating, based on radiological imaging of a region of a brain of a patient and BS electrode lead(s), a patient-specific anatomical model of the region and lead(s); populating the patient-specific anatomical model with neuron models based on associated neuronal densities of at least one of the region or one or more sub-regions of the region; constructing a patient-specific local field potential (LFP) model of the region based on the patient-specific anatomical model and location(s)/orientation(s) of the one or more BS electrode leads; and identifying, via the patient-specific LFP model of the region, a target area within the region for at least one of monitoring or treatment of a medical condition via the one or more BS electrode leads.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: April 5, 2022
    Assignee: Case Western Reserve University
    Inventors: Cameron McIntyre, Nicholas Maling, Scott Lempka
  • Patent number: 11285325
    Abstract: In a patient suffering from neural impairment, stimulation is provided to sensory surfaces of the face and/or neck, or more generally to areas of the body that stimulate the trigeminal nerve, while performing an activity intended to stimulate a brain function to be rehabilitated. The simulation may then be continued after the performance of the activity has ceased. It has been found that the patient's performance of the activity is then improved after stimulation has ceased. Moreover, it tends to improve to a greater extent, and/or for a longer time, when the post-activity stimulation is applied, as compared to when post activity stimulation is not applied.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: March 29, 2022
    Inventors: Yuri P. Danilov, Mitchell E. Tyler, Kurt A. Kaczmarek
  • Patent number: 11285329
    Abstract: Methods and systems can facilitate visualizing cathodic and anodic stimulation separately. Alternately, the methods and systems may separately visualize stimulation of different neural elements, such as nerve fibers and neural cells. These methods and systems can further facilitate programming an electrical stimulation system for stimulating patient tissue.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: March 29, 2022
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Stephen Carcieri, Vikrant Venkateshwar Gunna Srinivasan, Chirag Shah, Peter J. Yoo, Michael A. Moffitt, Sridhar Kothandaraman
  • Patent number: 11273310
    Abstract: A system and method for optimizing parameters of a DBS pulse signal for treatment of a patient is provided. In predicting optimal DBS parameters, functional brain data is input into a predictor system, the functional brain data acquired responsive to a sweeping across a multi-dimensional parameter space of one or more DBS parameters. Statistical metrics of brain response are extracted from the functional brain data for one or more ROIs or voxels of the brain via the predictor system, and a DBS functional atlas is accessed, via the predictor system, that comprises disease-specific brain response maps derived from DBS treatment at optimal DBS parameter settings for a plurality of diseases or neurological conditions. One or more optimal DBS parameters are predicted for the patient based on the statistical metrics of brain response and the DBS functional atlas via the predictor system.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: March 15, 2022
    Assignees: General Electric Company, Albany Medical College
    Inventors: Radhika Madhavan, Jeffrey Ashe, Suresh Joel, Ileana Hancu, Julie Pilitsis, Marisa DiMarzio