Treating Mental Or Emotional Disorder Patents (Class 607/45)
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Patent number: 12168134Abstract: A method of locating an implantation site in the brain includes inserting a plurality of multi-contact electrodes into a region of a target structure in an individual's brain. High Frequency Stimulation (HFS) is applied to a contact of a multi-contact electrode of the plurality of multi-contact electrodes. High Frequency Oscillations (HFO) evoked in the region of the target structure by the HFS are measured. Evoked Compound Activity (ECA) evoked in the region of the target structure by the HFS is measured. It is determined if at least one of the HFO and the ECA is above a predetermined threshold. If at least one of the HFO and the ECA is above the predetermined threshold, a location of the contact of the multi-contact electrode is identified as a site for electrode implantation in the individual's brain.Type: GrantFiled: August 12, 2021Date of Patent: December 17, 2024Assignee: UNIVERSITY OF HOUSTON SYSTEMInventors: Nuri F. Ince, Musa Ozturk, Ashwin Viswanathan
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Patent number: 12168121Abstract: Devices, systems and methods are disclosed for treating or preventing a developmental disorder, such as attention-deficit hyperactivity disorder (ADHD), an autism spectrum disorder, Asperger syndrome, childhood disintegrative disorder, overactive disorder, pervasive developmental disorder. A device comprises an electrode having a contact surface for contacting an outer skin surface of a patient and a power source coupled the electrode. The power source generates and transmits an electrical impulse having a frequency of about 1 kHz to about 20 kHz through the contact surface and the outer skin surface to a nerve within the patient. The electrical impulse is sufficient to modify the behavioral disorder in the patient.Type: GrantFiled: December 19, 2022Date of Patent: December 17, 2024Assignee: ELECTROCORE, INC.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Patent number: 12161609Abstract: Autism (ASD) symptoms of aggression-toward others or self, and paranoia with social isolation, are presently treated with antipsychotic medications such as haloperidol, Thorazine, and newer generation antipsychotics risperidone and aripiprazole (latter two are the only FDA approved drugs for treating autism irritability/aggression). But these antipsychotics including the newer generation, after a two or more years of use, often lead to irreversible tardive dyskinesia, other dystonias, loss of effectiveness, and brain volume loss. The present invention overcomes the irreversible tardive dyskinesia and dystonias and loss of effectiveness with long term-use of antipsychotics, by replacing the antipsychotic completely with a three (3) drug novel composition consisting of fluoxetine or sertraline with guanfacine and oxcarbazepine.Type: GrantFiled: June 25, 2021Date of Patent: December 10, 2024Inventor: John Nagle
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Patent number: 12161478Abstract: A system and method for scoring movement disorder symptoms comprises a movement measurement data acquisition system and processing comprising kinematic feature extraction and an algorithm trained using Unified Parkinson's Disease Rating Scale (UPDRS) scores from skilled clinicians. The movement data acquisition system, or “movement measuring apparatus,” may comprise sensors such as accelerometers or gyroscopes or may utilize motion capture and/or machine vision technology or various other methods to measure tremor, bradykinesia, dyskinesia, or other movement disorders in a subject afflicted with Parkinson's disease, essential tremor or the like. The method outputs, and system displays, a score that uses the same scale as the UPDRS but has greater resolution and lower variability.Type: GrantFiled: May 18, 2022Date of Patent: December 10, 2024Assignee: Great Lakes NeuroTechnologies Inc.Inventors: Dustin A. Heldman, Joseph P. Giuffrida
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Patent number: 12144555Abstract: An augmented reality-assisted method for performing surgery comprises: disposing a position sensing element at a facial positioning point of a patient before craniotomy to obtain skull space and intracranial space information for defining a coordinate space; obtaining a brain anatomical image for constructing a three-dimensional graphic, the graphic comprising a graphic positioning point and a feature associated with a gyrus feature; defining a relative positional relationship between the graphic and the space, aligning the facial positioning point with the graphic positioning point; using a probe to obtain a spatial position of the gyrus feature after craniotomy, using the gyrus feature as a calibration reference point; generating a displacement and rotation parameter based on a coordinate difference of the feature relative to the reference point; adjusting a position and/or an angle of the graphic on a display according to the parameter, and the display displaying the calibrated three-dimensional graphic.Type: GrantFiled: December 17, 2021Date of Patent: November 19, 2024Assignee: MEDICALTEK CO., LTD.Inventors: Yen-Yu Wang, Shu-Jui Hsieh, Jing-Ying Huang
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Patent number: 12144986Abstract: Disclosed is a system including a good comprising a sensor in contact with human tissues of a patient and configured to obtain a power dissipation reading of the human tissues. The good also includes a storage medium for tangibly storing thereon a program for execution by a processor. The system also includes a control unit in communication with the good to form an electrical muscular stimulation (EMS) system that uses feedback in a closed loop manner to self tune electrical properties of the output. The control unit is configured to instruct the sensor to (a) apply a sense pulse to the human tissues, (b) measure power dissipation of the sense pulse, (c) adjust a stimulation pulse based on the measured power dissipation, (d) apply the stimulation pulse to the human tissues based on the power dissipation and based on the program in order to maintain constant power output across each pulse, and (e) repeat steps (a)-(d).Type: GrantFiled: April 9, 2021Date of Patent: November 19, 2024Assignee: MOTIVE HEALTH, INC.Inventors: Struan Coleman, Calvin Domenico, Edison Gieswein
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Patent number: 12144583Abstract: Systems and methods are contemplated for monitoring and analyzing the glymphatic system and brain to predict, prognose, diagnose, treat, modify or improve treatment, and track progression of neurological diseases. A first and second MRI image are taken of an extracellular space in a region of interest in a patient's brain, with one image taken while the patient is awake and the other image taken while the patient is asleep. The first and second images are compared to detect changes in the extracellular space, and the comparison is used to predict, prognose, diagnose, treat, modify or improve treatment, and track progression of neurological diseases associated with the extracellular space.Type: GrantFiled: March 20, 2020Date of Patent: November 19, 2024Assignee: Synaptec Network, Inc.Inventor: Sheldon Jordan
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Patent number: 12144590Abstract: Device for measuring jugular venous pressure of a human patient, comprising: (1) A body including a base configured to rest on the patient and align with at least one of the patient's manubrium, sternum and sternal angle and a light emitter assembly configured to project a pattern of light onto the neck of the patient proximate to the patient's jugular vein. (2) Two side arms extending from the body, each side arm being configured to rest on at least one of the patient's upper chest and clavicle. (3) At least one camera associated with one of the side arms, the at least one camera positioned and oriented to capture images of the patient's neck with the pattern of light projected thereon. Methods are also disclosed.Type: GrantFiled: February 19, 2021Date of Patent: November 19, 2024Assignee: JRAS MEDICAL, INC.Inventors: Andrew J. Smith, Andrew M. L. Smith, Jason Roberts
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Patent number: 12138456Abstract: The invention provides methods for treating a neurological disorder or deficit, such as tinnitus and phantom limb pain.Type: GrantFiled: February 11, 2021Date of Patent: November 12, 2024Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Hubert H. Lim, Craig D. Markovitz, Sarah J. Offutt
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Patent number: 12143372Abstract: A system and method for secure wireless control of a device including, but not limited to, replay attack protection, man-in-the-middle protection, data obfuscation, and challenge-response authentication. The system includes a control device, a controlled device interface, a controlled device, a control device interface, and a wireless link. The controlled device interface and the control device interface manage secure communications between the control device and the controlled device over the wireless link. The controlled device can include a medical device such as, for example, but not limited to, an insulin pump and a wheelchair.Type: GrantFiled: January 8, 2021Date of Patent: November 12, 2024Assignee: DEKA Products Limited PartnershipInventors: James J. Dattolo, Atlant G. Schmidt, III, Steven B. Meuse, George W. Marchant, Jr.
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Patent number: 12138458Abstract: A method is described, which provides electrical stimulation to a person, where the current flows from a subcranial electrode, through a target brain region, through a separate conductive path, and back to a subcutaneous electrode, and where the parameters of the electric current pulses are set to influence the resonant properties of the brain.Type: GrantFiled: July 13, 2021Date of Patent: November 12, 2024Assignee: Epic Neuro, Inc.Inventor: James William Phillips
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Patent number: 12138064Abstract: A sensor of an implantable medical device senses electrical activity of the brain. A data analyzer of the device monitors an electrographic signal corresponding to the electrical activity of the sensed brain signal, and processes the brain signal to obtain a measure of phase-amplitude coupling. For a selected portion of the electrographic signal, the data analyzer detects first features and second features of the electrographic signal. The first features represent oscillations in a low frequency range, while the second features represent oscillations in a frequency range higher than the low frequency range. For example, the low frequency range may correspond to theta frequency and the higher frequency range may correspond to gamma frequency. The data analyzer determines a measure of phase-amplitude coupling between oscillations in the low frequency range and oscillations in the higher frequency range based on occurrences of second features which coincide with first features.Type: GrantFiled: March 3, 2021Date of Patent: November 12, 2024Assignee: NeuroPace, Inc.Inventors: Sharanya Arcot Desai, Thomas K. Tcheng, Stephen T. Archer
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Patent number: 12133982Abstract: Devices, systems, and techniques for controlling electrical stimulation therapy are described. In one example, a system may be configured to deliver electrical stimulation therapy to a patient, the electrical stimulation therapy comprising a plurality of therapy pulses at a predetermined pulse frequency over a period of time and deliver, over the period of time, a plurality of control pulses interleaved with at least some therapy pulses of the plurality of therapy pulses. The system may also be configured to sense, after one or more control pulses and prior to an immediately subsequent therapy pulse of the plurality of therapy pulses, a respective evoked compound action potential (ECAP), adjust, based on at least one respective ECAP, one or more parameter values that at least partially defines the plurality of therapy pulses, and deliver the electrical stimulation therapy to the patient according to the adjusted one or more parameter values.Type: GrantFiled: September 24, 2021Date of Patent: November 5, 2024Assignee: Medtronic, Inc.Inventors: David A. Dinsmoor, Heather Diane Orser, Scott R. Stanslaski, Erik J. Peterson
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Patent number: 12121727Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.Type: GrantFiled: April 11, 2023Date of Patent: October 22, 2024Assignee: Flint Hills Scientific, LLCInventor: Ivan Osorio
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Patent number: 12109417Abstract: Systems and methods for deep brain stimulation using kinematic feedback in accordance with embodiments of the invention are illustrated. One embodiment includes a deep brain stimulation system, including an implantable neurostimulator, a first inertial measurement unit (IMU), a second IMU, and a controller, where the controller is communicatively coupled to the implantable neurostimulator, the first IMU, and the second IMU, and where the controller is configured to obtain kinematic data from the first IMU and the second IMU, identify an abnormal movement event based on the kinematic data, and modify deep brain stimulation provided by the implantable neurostimulator based on the identified abnormal movement event.Type: GrantFiled: February 1, 2022Date of Patent: October 8, 2024Assignees: The Board of Trustees of the Leland Stanford Junior University, University of WashingtonInventors: Helen Bronte-Stewart, Yasmine Kehnemouyi, Matthew Petrucci, Jeffrey Herron, Johanna O'Day
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Patent number: 12109410Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating other ailments, such as erectile dysfunction, aortic aneurysm, and failing heart valves.Type: GrantFiled: March 29, 2021Date of Patent: October 8, 2024Assignee: LEONHARDT VENTURES LLCInventors: Howard J. Leonhardt, Jorge Genovese
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Patent number: 12114120Abstract: An earphone housing includes an inserter to be inserted into an outer ear hole, and a main body to be coupled to the inserter. The main body includes a bottom surface to contact a surface of a cavum concha, and a side surface to contact a tragus and an antitragus. The side surface includes a depressed part depressed inward and contacting a top of the antitragus, and the side surface contacts the tragus at a part other than the depressed part.Type: GrantFiled: October 11, 2022Date of Patent: October 8, 2024Assignee: Yamaha CorporationInventors: Yasuaki Takano, Hiroyuki Ayame, Tomoaki Mori, Kazuki Kashiwase, Sena Otsuka
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Patent number: 12097052Abstract: Disclosed are systems and methods for detecting a fall of a user of a wearable device. The described system samples signal data from an accelerometer of the wearable device and performs a preliminary determination of fall detection using pattern recognition. This preliminary detection may be based on whether a first portion of the signal data exceeds a first threshold indicative of a fall of a wearer of the electronic device and whether a second portion of the signal data is within a range indicative of motion stillness following the fall. The described system further applies a machine learning classifier to the signal data associated with the preliminary indication to generate a fall classification indicating the signal data represents a fall of the wearer of the electronic device.Type: GrantFiled: August 24, 2022Date of Patent: September 24, 2024Assignee: Gaia Connect Inc.Inventor: Adinel Tudor
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Patent number: 12090317Abstract: A system for brain stimulation of a patient is provided, the system having an implantable stimulator, at least one sensor component for acquiring at least one measure indicative of patient's mood, and at least one implantable stimulation electrode, designed for providing electrical pulses stimulating inside the patient's brain. The at least one stimulation electrode is connectable, through an implantable connector, to the implantable stimulator, the implantable stimulator having at least one programmable channel for conducting the electrical stimulation pulses to the at least one stimulation electrode, and being adapted for receiving continuous input signals from the at the least one sensor component. The system also has a computational unit for processing the at least one measure, and a patient's body external control interface (5) for patient and/or physician interactions.Type: GrantFiled: November 5, 2021Date of Patent: September 17, 2024Assignee: CorTec GmbHInventors: Joern Rickert, Martin Schuettler, Volker A. Coenen, Thomas Schlaepfer, Michael Tangermann
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Patent number: 12076554Abstract: Electrical stimulation of specific facial and lingual nerves creates a more sustained pulsatility activity compared to stimulation of other cranial nerves. Pulsatility of arteries has intrinsic time constraints related to the time for vasodilation/constriction and time to return to baseline (TBL) after electrical stimulation which may affect the pulsatility response. Control of temporal patterning and the stimulation waveform maximizes the physiological response to cerebral pulsatility and its resulting effects on cerebral spinal fluid penetration into the brain parenchyma for a multitude of therapeutic uses including clearing misfolded proteins and/or administered pharmacological agents, diluting endogenous neurochemical concentrations within the brain, and reducing non-synaptic coupling.Type: GrantFiled: June 30, 2022Date of Patent: September 3, 2024Assignee: Wisconsin Alumni Research FoundationInventors: Kip Ludwig, Justin Williams, Angela Williams, Samuel Poore
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Patent number: 12076563Abstract: A neural stimulator, suitable for implanting in a recipient, and configured to combine vagal nerve stimulation (VNS) with cochlear stimulation, to result in faster adaptation to new sounds and maps, and alleviation of tinnitus in the recipient.Type: GrantFiled: December 7, 2022Date of Patent: September 3, 2024Assignee: Cochlear LimitedInventor: Paul Michael Carter
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Patent number: 12070278Abstract: A method for determining position of an electrode lead inside a body tissue, including: receiving electrical signals recorded from at least one macro electrode contact of an electrode lead positioned inside a body tissue; extracting spiking (SPK) signals from the received electrical signals; providing stored measurements or indications thereof; determining a position of the lead and/or the at least one macro electrode contact inside said body tissue based on the extracted SPK signals and the provided stored measurements or indications thereof.Type: GrantFiled: June 26, 2020Date of Patent: August 27, 2024Assignee: Alpha Omega Engineering Ltd.Inventors: Hagai Bergman, Salam Aukal
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Patent number: 12070606Abstract: A neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of electrodes, a user interface configured for receiving input from a user that selects one of a plurality of different shapes of a modulating signal and/or selects one of a plurality of different electrical pulse parameters of an electrical pulse train, neuromodulation output circuitry configured for outputting an electrical pulse train to the plurality of electrical terminals, and pulse train modulation circuitry configured for modulating the electrical pulse train in accordance with the selected shape of the modulating signal and/or selected electrical pulse parameter of the electrical pulse train.Type: GrantFiled: December 27, 2021Date of Patent: August 27, 2024Assignee: Boston Scientific Neuromodulation CorporationInventor: Changfang Zhu
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Patent number: 12064624Abstract: A method of applying electrode elements configured in an array of elements to an individual's skin, the electrode elements being part of an apparatus for delivering a plurality of electromagnetic fields to the body of the individual, the method comprising the steps of: positioning, applying, holding and bowing. The positioning step includes the positioning of each of the electrode elements of the array of elements into corresponding cavities in at least one holding rack. The applying step includes the applying of a medical adhesive to a surface of the plurality of electrode elements. The holding step includes the holding of the holding rack against the skin at a selected location. The bowing step includes the bowing of a portion of the holding rack causing one of the electrode elements to pop out of the holding rack, with the electrode element adhering to the skin by way of the medical adhesive.Type: GrantFiled: March 16, 2023Date of Patent: August 20, 2024Assignee: LifeBridge Innovations, PBCInventors: Peter F. Travers, Ken Watkins, Scott Krywick, Matthew Travers
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Patent number: 12064629Abstract: In a patient suffering from neural impairment, stimulation is provided to sensory surfaces of the face and/or neck, or more generally to areas of the body that stimulate the trigeminal nerve, while performing an activity intended to stimulate a brain function to be rehabilitated. The simulation may then be continued after the performance of the activity has ceased. It has been found that the patient's performance of the activity is then improved after stimulation has ceased. Moreover, it tends to improve to a greater extent, and/or for a longer time, when the post-activity stimulation is applied, as compared to when post activity stimulation is not applied.Type: GrantFiled: March 25, 2022Date of Patent: August 20, 2024Assignee: Advanced Neurorehabilitation, LLCInventors: Yuri P. Danilov, Mitchell E. Tyler, Kurt A. Kaczmarek
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Patent number: 12064630Abstract: Systems and Methods for Monitoring Neural Activity A method of monitoring neural activity responsive to a stimulus in a brain or a subject under general anaesthetic, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.Type: GrantFiled: May 3, 2019Date of Patent: August 20, 2024Assignee: DEEP BRAIN STIMULATION TECHNOLOGIES PTY. LTD.Inventors: Nicholas Sinclair, Hugh McDermott, Kristian Bulluss, Arthur Wesley Thevathasan, Joel Villalobos
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Patent number: 12064634Abstract: This disclosure relates to methods for modifying neural activity by applying electrical current to a neural tissue, e.g., in a transcranial DC stimulation procedure (tDCS), a transcranial AC stimulation procedure (tACS), a transcranial random noise stimulation procedure (tRNS), a deep brain stimulation procedure (DBS), a transcutaneous electrical nerve stimulation procedure (TENS), or the like. Historically, computed potential, electrical field, and/or current density distributions have been used to select the locations of the electrodes that apply the electrical current. In the present disclosure, a computed charge distribution on the bounding surface of one or more sulci filled with cerebrospinal fluid (CSF) is used in selecting the electrode locations. In one embodiment, the sulcus's bounding surface is divided into pixels and each pixel's charge is determined by the pixel functioning as a sensor for the charges surrounding it, including the charges of other pixels and the charges on the electrodes.Type: GrantFiled: August 7, 2020Date of Patent: August 20, 2024Inventor: Maurice M. Klee
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Patent number: 12064628Abstract: Apparatuses and methods for treating neurological disorders by electro-stimulation. The apparatus may include a neural input signal acquisition module having a front-end block configured to amplify the potential difference of its input signals (V1a, V2a) and to filter a stimulus artifact and may include a multi-stage fully-differential switched capacitor circuit (e.g., an integrated circuit) configured for discrete-time signal processing.Type: GrantFiled: May 18, 2023Date of Patent: August 20, 2024Assignee: Newronika S.p.A.Inventors: Daniel Senderowicz, Mattia Arlotti, Nicolo' Vieno, Lorenzo Rossi
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Patent number: 12053633Abstract: The present disclosure provides a grip sensor for quantifying pain experienced by a patient during spinal cord stimulation (SCS). The grip sensor includes an electronics enclosure, an annular outer shell substantially surrounding the electronics enclosure and sized to be held by the patient, a pressure sensor embedded in the outer shell and communicatively coupled to the electronics enclosure, the pressure sensor configured to measure a grip strength of the patient as SCS is applied to the patient, and a plurality of galvanic skin response sensors communicatively coupled to the electronics enclosure and configured to measure an electrical impedance of the skin of the patient as SCS is applied to the patient.Type: GrantFiled: July 7, 2021Date of Patent: August 6, 2024Assignee: Pacesetter, Inc.Inventors: Alexander Kent, Edward Karst, Gene A. Bornzin
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Patent number: 12053631Abstract: Methods for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by electrical stimulation of a nerve. The method comprises applying a first stimulus to a patient having a medical condition and measuring a first baseline physiological response from the patient. An electrical impulse is applied to a nerve within the patient and second stimulus is applied to the patient. A second physiological response evoked by the second stimulus is measured and compared to the first baseline physiological response. The methods may be used to optimize the placement of a stimulator, to test whether a patient is a suitable candidate for treatment using nerve stimulation, and/or to select the stimulation parameters that optimize acute or chronic treatment.Type: GrantFiled: May 12, 2021Date of Patent: August 6, 2024Assignee: ELECTROCORE, INCInventors: Bruce J. Simon, Joseph P. Errico
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Patent number: 12029894Abstract: In an embodiment, an electrical stimulation system can include one or more of an electrode assembly including one or more electrodes and an electronics subsystem. In some variations, each of the one or more electrodes can include a hydrophilic layer and a conductive layer. In some variations, the electronics subsystem can include one or more of a control module, power module, and a stimulus generator. In some variations, the electrical stimulation can further include one or more of an electrical attachment system, mechanical attachment system, head apparel assembly, flexible housing, and/or any other suitable component. The electrical stimulation system functions to apply electrical stimulation but can additionally or alternatively function to measure/and or record one or more biosignals from a user.Type: GrantFiled: August 24, 2021Date of Patent: July 9, 2024Assignee: Flow Neuroscience, Inc.Inventors: Brett Wingeier, Ian Shain, Colin Davis, Victoria Hammett, Mardis Bagley, Phnam Bagley
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Patent number: 12029907Abstract: Methods and apparatus for improving cognitive function within a human. The invention utilizes a neurostimulation device, such as a signal generator, to affect tissue elements at a lateral temporal lobe of the human brain. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various characteristics of cognition. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation therapy.Type: GrantFiled: July 19, 2017Date of Patent: July 9, 2024Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Michael Kahana, Daniel Sutton Rizzuto
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Patent number: 12029901Abstract: This disclosure describes methods and systems for preventing, moderating, and/or treating brain injury. The methods herein may include obtaining a test result reflecting a condition of a brain in the subject, determining a stimulation parameter based on the test result, and stimulating a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject. The systems herein may include a processor configured to: receive a test result reflecting a condition of a brain in a subject, and determine a stimulation parameter based on the test result; and a stimulator configured to stimulate a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject.Type: GrantFiled: June 29, 2018Date of Patent: July 9, 2024Assignee: Lungpacer Medical Inc.Inventors: Douglas G. Evans, Viral S. Thakkar, Matthew J. Gani
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Patent number: 12029701Abstract: An auricular peripheral nerve field stimulator may include at least one therapy electrode configured for percutaneous insertion into an auricle of a human ear near at least one neurovascular bundle located therein, and an electrical stimulation device electrically coupled to the electrical stimulation device, the electrical stimulation device programmed to generate and deliver electrical stimulation signals, with defined stimulation parameters, to the at least one therapy electrode to stimulate, with the at least one therapy electrode percutaneously inserted, at least one auricular peripheral nerve field within the auricle, the defined stimulation parameters including a defined pulse frequency and at least one of a defined pulse width and a defined duty cycle.Type: GrantFiled: January 13, 2023Date of Patent: July 9, 2024Assignee: Neuraxis, Inc.Inventors: Christopher R. Brown, Gary M. Peterson
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Patent number: 12029581Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.Type: GrantFiled: June 14, 2021Date of Patent: July 9, 2024Assignee: NeuroPace, Inc.Inventors: Tara L. Crowder, Brett M. Wingeier, Martha J. Morrell, Felice Sun, Thomas Tcheng
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Patent number: 12023501Abstract: Devices, systems, and techniques for controlling electrical stimulation therapy are described. In one example, a system may be configured to deliver electrical stimulation therapy to a patient, the electrical stimulation therapy comprising a plurality of therapy pulses at a predetermined pulse frequency over a period of tune and deliver, over the period of time, a plurality of control pulses interleaved with at least some therapy pulses of the plurality of therapy pulses. The system may also be configured to sense, after one or more control pulses and prior to an immediately subsequent therapy pulse of the plurality of therapy pulses, a respective evoked compound action potential (ECAP), adjust, based on at least one respective ECAP, one or more parameter values that at least partially defines the plurality of therapy pulses, and deliver the electrical stimulation therapy to the patient according to the adjusted one or more parameter values.Type: GrantFiled: September 24, 2021Date of Patent: July 2, 2024Assignee: Medtronic, Inc.Inventors: David A. Dinsmoor, Kristin N. Hageman, Hank Bink
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Patent number: 12023494Abstract: The present invention relates to a device for performing a tVNS treatment having at least one electrode for generating a stimulation pulse, with the device having at least one detection means that is configured to detect one or more parameter values, and with the device having a control or regulation unit that is suitable to set one or more parameters of the stimulation pulse delivered by the electrode in dependence on the detected parameter value or values.Type: GrantFiled: August 7, 2020Date of Patent: July 2, 2024Assignee: TVNS TECHNOLOGIES GMBHInventors: Armin Bolz, Klaus Karg
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Patent number: 12023500Abstract: A method of treating a medical condition in a patient using an implantable medical device, the implantable medical device including a first electrode coupled to a first cranial nerve structure and a second electrode coupled to a second cranial nerve structure, the method comprising: providing a first electrical signal to the first cranial nerve structure of the patient; providing a second electrical signal to the second cranial nerve structure of the patient; administering to the patient a responsiveness test and comparing a result of the responsiveness test to a baseline responsiveness test; and initiating a second therapy or issuing a warning based on the comparison of the result of the responsiveness test to the baseline responsiveness test.Type: GrantFiled: March 8, 2023Date of Patent: July 2, 2024Assignee: Flint Hills Scientific, LLCInventor: Ivan Osorio
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Patent number: 12011290Abstract: A medical data processing method is provided and includes: acquiring medical image data describing a digital image of an anatomical body part containing at least one nerve fibre extending between an internal part of the anatomical body part and a substantially exterior part of the anatomical body part; and acquiring atlas data describing an image-based model of the anatomical body part. The method determines, based on the medical image data and the atlas data, exterior part data describing an association between the exterior part and the nerve fibre. The method further acquires a predetermined applied stimulation signal applied to, based on the exterior part data, the exterior part and an emitted stimulation signal emitted by the nerve fibre. Correspondence measure data describing a measure of correspondence between the applied stimulation signal and the emitted stimulation signal is then determined.Type: GrantFiled: November 8, 2017Date of Patent: June 18, 2024Assignee: BRAINLAB AGInventor: Bálint Varkuti
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Patent number: 12005251Abstract: The present invention provides materials and methods for using electrical stimulation to treat a mammal having a proteinopathy (e.g., neurodegenerative diseases) or at risk of developing a proteinopathy are provided. For example, the present invention provides materials and methods for modulating glymphatic clearance (e.g., enhancing glymphatic clearance) of pathogenic proteins.Type: GrantFiled: August 10, 2022Date of Patent: June 11, 2024Assignees: Wisconsin Alumni Research Foundation, Mayo Foundation for Medical Education and ResearchInventors: Justin Williams, Kip Ludwig, Erika Ross
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Patent number: 12004840Abstract: Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal.Type: GrantFiled: July 7, 2017Date of Patent: June 11, 2024Assignee: The Regents of the University of CaliforniaInventors: Michel M. Maharbiz, Dongjin Seo, Konlin Shen, Jose M. Carmena, Ryan Neely, Elad Alon, Jan Rabaey
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Patent number: 12009785Abstract: In some embodiments, there is provided an apparatus including a common bus and a plurality of oscillatrode circuits coupled to the common bus, the plurality of oscillatrode circuits including a first oscillatrode circuit outputting a first frequency tone when a first input voltage is detected by the first oscillatrode circuit and a second oscillatrode circuit outputting a second frequency tone when a second input voltage is detected by the second oscillatrode circuit, wherein common bus carries the first frequency tone and the second frequency tone at different frequencies in a frequency division multiplex signal. Related systems, methods, and articles of manufacture are also disclosed.Type: GrantFiled: December 13, 2019Date of Patent: June 11, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jun-Chau Chien, Mohammad Amin Arbabian
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Patent number: 11992289Abstract: A method includes using fully sampled retro cine data to train an algorithm, and applying the trained algorithm to real time MR cine data to yield reconstructed MR images.Type: GrantFiled: October 1, 2020Date of Patent: May 28, 2024Assignee: Shanghai United Imaging Intelligence Co., Ltd.Inventors: Zhang Chen, Xiao Chen, Shanhui Sun, Terrence Chen
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Patent number: 11992683Abstract: Aspects of the subject disclosure may include, for example, a method and apparatus for measuring a bioimpedance and performing an electrical stimulation, the method including generating a first current corresponding to a first high-frequency, generating a second current corresponding to a second high-frequency, generating a low-frequency current based on a beat phenomenon of the first current and the second current, and calculating an impedance of a target part based on a voltage induced to the target part by a high-frequency current corresponding to at least one of the first current and the second current and the low-frequency current.Type: GrantFiled: March 7, 2023Date of Patent: May 28, 2024Assignee: Samsung Electronics Co., Ltd.Inventors: Hyungwoo Lee, Sang Joon Kim, Jongpal Kim
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Patent number: 11992671Abstract: The present disclosure is in the field of sleep and respiratory care. In particular, the present disclosure provides means and methods for decreasing the respiratory effort of a sleeping subject. The present disclosure also provides means and methods for treating the snoring of a sleeping subject.Type: GrantFiled: October 1, 2021Date of Patent: May 28, 2024Assignee: Sunrise SAInventor: Pierre Martinot
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Patent number: 11975195Abstract: The present invention relates to methods for remotely and intelligently tuning movement disorder of therapy systems. The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson's disease and Parkinsonism, Dystonia, Chorea, and Huntington's disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of remotely and intelligently or automatically tuning a therapy device using objective quantified movement disorder symptom data to determine the therapy setting or parameters to be transmitted and provided to the subject via his or her therapy device. The present invention also provides treatment and tuning intelligently, automatically and remotely, allowing for home monitoring of subjects.Type: GrantFiled: March 2, 2021Date of Patent: May 7, 2024Assignee: Great Lakes NeuroTechnologies Inc.Inventors: Dustin A Heldman, Christopher L Pulliam, Joseph P Giuffrida, Thomas O Mera
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Patent number: 11975199Abstract: A device may receive, from one or more electrodes, information identifying brain activity for a first time period. The device may predict, based on the information identifying the brain activity for the first time period, predicted brain activity for a second time period that is to occur after the first time period. The device may determine, based on the predicted brain activity for the second time period, a brain stimulus for the second time period, wherein the brain stimulus is associated with a frequency and a phase determined based on the predicted brain activity for the second time period. The device may cause the brain stimulus to be applied in accordance with the frequency and the phase during the second time period.Type: GrantFiled: January 31, 2020Date of Patent: May 7, 2024Assignee: The Johns Hopkins UniversityInventors: William S. Anderson, Yousef Salimpour, L. Leon Chen, Kelly Mills
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Patent number: 11975187Abstract: Techniques are disclosed for delivering electrical stimulation therapy to a patient. In one example, a medical system delivers electrical stimulation therapy to a tissue of the patient via electrodes. The medical system determines a first change of a first sensed signal of the patient to movement by the patient and a second change of a second sensed signal of the patient to the movement by the patient. Based on the first change and the second change, the medical system selects one of the first sensed signal and the second sensed signal of the patient for controlling the electrical stimulation therapy. The medical system adjusts a level of at least one parameter of the electrical stimulation therapy based on the selected one of the first sensed signal and the second sensed signal.Type: GrantFiled: November 13, 2020Date of Patent: May 7, 2024Assignee: Medtronic, Inc.Inventors: Scott R. Stanslaski, Timothy R. Abraham, Thomas Adamski, Timothy J. Denison, Robert S. Raike
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Patent number: 11964157Abstract: A system includes processing circuitry configured to determine, for each respective electrode of a plurality of electrodes, a score based on a ratio of an electrical efficiency for the respective electrode to a therapeutic window for the respective electrodes. The processing circuitry is further configured to determine, based on the score of each respective electrode, a ranking of the plurality of electrodes, and to select, based on the ranking, a subset of the plurality of electrodes for delivery of electrical stimulation therapy.Type: GrantFiled: December 10, 2020Date of Patent: April 23, 2024Assignee: Medtronic, Inc.Inventor: Janardan Vaidyanathan
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Patent number: 11964155Abstract: A method of rapid frequency cycling during electrical stimulation according to an embodiment may include determining, by a controller of an electrical stimulation system, a plurality of frequency band groupings of discrete frequency bands of an electrical stimulation signal having a frequency range, wherein each frequency band grouping includes at least one discrete frequency band, wherein a corresponding current or voltage amplitude of the electrical stimulation signal is independently tuned within each discrete frequency band based on feedback received from a patient, determining, by the controller, a random sequence of the frequency band groupings of the plurality of frequency band groupings, generating, by at least one signal generator controlled by the controller, the electrical stimulation signal according to the determined random sequence of the frequency band groupings, and delivering the generated electrical stimulation signal through an electrode array to the patient to provide therapy to the patienType: GrantFiled: July 14, 2023Date of Patent: April 23, 2024Assignee: Soin Neuroscience, LLCInventors: Amol Soin, Eric A. Schepis