Abstract: A device for sensing and communicating nerve cell endings and neural signals, the device comprising: at least one neural bridge device; at least one neural bridge switch, wherein each neural bridge switch is an implanted integrated circuit and is connected to at least one neural bridge device; at least one neural bridge gateway; at least one communication means in communication with at least one neural bridge gateway and at least one neural bridge switch; at least one sensory interface integrated circuit in communication with at least one neural bridge switch; at least one transducer in communication with at least one sensory interface integrated circuit; and at least one attachment means in communication with at least one transducer.

Abstract: A negative wound pressure therapy apparatus includes a wound dressing for defining a reservoir over a wound in which a negative pressure may be maintained by forming a substantially fluid-tight seal around wound tissue. The apparatus also includes a fluid conduit in fluid communication with the reservoir. The fluid conduit defines a fluid flow path for carrying fluids from the reservoir. The apparatus also includes a vacuum source in fluid communication with the fluid conduit. The vacuum source is suitable for providing an appropriate negative pressure to the reservoir to stimulate healing of the wound. The apparatus also includes at least one biomedical electrode mounted with respect to the wound dressing for transmitting electrical energy to stimulate healing of the wound tissue.

Abstract: A cell construct includes cells in contact with at least one basement membrane and/or at least one stroma, wherein the basement membrane or stroma contains elements for applying mechanical stimulation on the cells. The process of manufacture of the cell construct and its use, as well as a device, an implant and processes for the mechanical stimulation of cells in vitro and in vivo are also described.

Abstract: In one example, the present invention is directed to a wound-healing patch including a flexible substrate, at least one wound electrode, at least one guard electrode and at least one return electrode. The guard electrode is positioned between the wound and return electrodes in the electrical path of current traveling between the return and wound electrodes on the surface of the skin, sinking the surface current and force the wound current to travel deeper into the tissue. In the invention, the wound electrode(s) is positioned on a portion of the flexible substrate designed to be placed over wounded tissue and the return electrode is positioned on a portion of the substrate substantially surrounding the wound and guard electrodes and is designed to be placed over healthy tissue.

Abstract: Electrode systems and methods are provided for applying electrical stimulation to a wound or skin. The electrode systems may include a feedback sensor configured to detect at least one wound healing factor or other treatment factors and may adjust the electrical stimulation based on feedback sensor measurements. The electrode systems may include multiple center electrodes for attachment to the wound. Multiple therapies may be stored on the electrode systems and a selected one of the stored therapies may be applied. A timer may be included to indicate the length of time a therapy has been applied. The electrode system may include a control module configured as a flexible circuit which conforms to the shape of the wound or the skin to which it is applied. In addition, a medical kit may be supplied for use in applying therapies, including multiple control modules and multiple electrodes.

Abstract: A method of treating a wound comprising the steps of placing a pair of electrodes placed spaced apart in the region of a wound and applying a predetermined sequence of current waveforms across the electrodes. The sequence of current waveforms comprises a first waveform comprising a series of current pulses having an amplitude in a range of from 80 to 300 ?A, having a frequency in a range from 0.5 to 1.5 pulses per second and a pulse width in a range from 333 to 1000 ms, a second waveform comprising a series of current pulses having an amplitude in a range of from 20 to 60 ?A, having a frequency in a range from 2 to 4 pulses per second and a pulse width in a range from 125 to 250 ms and a third waveform comprising a series of current pulses having an amplitude in a range of from 250 to 640 ?A, having a frequency in a range of from 80 to 120 pulses per second and a pulse width in a range from 4 to 6 ms.

Abstract: A method for treating an infected area on a subject, comprising the steps of: exposing the infected area to an aqueous solution; and providing direct current to the aqueous solution to treat the infected area.

Abstract: The present invention is generally directed to a method for regulating cellular and tissue physiology, a device for practicing the method, and a process for fabricating the device. In general the process comprises the steps of providing at least one patterned electrode, providing a least one cell, placing the at least one electrode in electrical communication with the at least one cell, and applying a voltage to the electrode thereby delivering an effective amount of a patterned electric field or current thus regulating the physiology and/or growth of the at least one cell.

Abstract: An electrode arrangement for applying electrical signals to skin of an animal comprising a flexible electrically non-conductive substrate, at least one electrode provided on a first surface of the substrate for applying electrical signals to the skin when placed on the skin, at least one connector connected to a respective electrode for providing electrical signals to the respective electrode and an electrically non-conductive sealing arrangement connected to the substrate for sealing the substrate and the skin to prevent ingress of moisture to the at least one electrode and to the at least one connector at the connection to the respective electrode. The or each electrode comprises a plurality of spaced electrically conductive elements to allow flexion of the electrode arrangement and electrically conductive material between the plurality of spaced electrically conductive elements to form a two-dimensional electrically conductive path across at least a portion of the first surface of the substrate.

Abstract: A method for treating an infected area on a subject, comprising the steps of: exposing the infected area to an aqueous solution; and providing direct current to the aqueous solution to treat the infected area.

Abstract: Various exemplary systems and methods for promoting nerve regeneration are disclosed. In certain exemplary embodiments, a nerve regeneration system may include a lead configured to be placed in a body proximate a damaged nerve, a portion of the lead being configured to stimulate the damaged nerve. The system may also include a control module configured to monitor a signal indicative of the nerve's response to the stimulation and adjust a parameter of the stimulation in response to the monitored signal.

Abstract: Various systems and methods for promoting nerve regeneration are disclosed. The system may include an elongated lead configured to be implanted within a patient's body. The system may also include a plurality of electrodes disposed along the elongated lead and configured to deliver electric stimulation to an area of a patient's body. The plurality of electrodes may comprise at least one transmitting electrode in communication with the controller, wherein the at least one transmitting electrode is configured to transmit an electric signal to one or more other electrodes. The controller may be configured to control operation of the at least one transmitting electrode.

Abstract: The invention includes an electro-acupuncture stimulation system for in vivo and in situ analgesia and tissue repair and regeneration. Electrodes, which can be acupuncture needles, are percutaneously implanted that deliver a pulsed electrical current that creates an electrical field, which envelopes the targeted tissue and restores cell-generating homeostasis to the affected tissue and thereby promotes analgesia and tissue re-growth in otherwise debilitated or deteriorating tissue. Methods and apparatuses are also disclosed that may include a needle locking system and acupuncture-needle assemblies for long-term in situ electrical stimulation.

Abstract: Described herein are electrical markers, specifically alternate current (AC) signals whose appearance in patients with wounds, specifically chronic wounds, correlates to the prognosis of the wounds. Related methods that can be used for diagnosis and treatment of wounds are disclosed. Also described herein are methods that can be used to identify electrical signals of wounds.

Abstract: Methods for the treatment of CNS damage are described, and include inducing in a subject in need of such treatment, a therapeutically effective amount of functional electronic stimulation (FES) sufficient to evoke patterned movement in the subject's muscles, the control of which has been affected by the CNS damage. The induction of FES-evoked patterned movement at least partially restores lost motor and sensory function, and stimulates regeneration of neural progenitor cells in the subject patient.

Abstract: An ophthalmic treatment method for inhibiting death of retinal constitutive cells of an eye by stimulating the cells includes a first step of placing a positive electrode and a negative electrode in such positions outside the eye that the electrodes provide electrical stimulation to the cells, at least one of the electrodes being placed on one of a cornea and sclera of the eye; and a second step of generating an electrical stimulation pulse having an electric current set at 20 ?A or more but not exceeding 300 ?A from each placed electrode.

Abstract: Embodiments are generally directed to improving the interface between one or more electrode contacts of a medical implant and the neurons of a recipient of the medical implant. In an embodiment, a growth factor is applied to stimulate the growth of peripheral processes (also referred to as dendrites). Then an electric field is applied to direct the growth of the peripheral processes towards the electrode contact. Growing peripheral processes towards the electrode contacts may reduce the charge required to stimulate the peripheral processes and improve operation of the medical implant.

Abstract: A high-frequency treatment apparatus includes a treatment high-frequency wave output unit configured to output a treatment high-frequency wave to be applied to a treatment target living tissue, a detection unit for detecting an impedance of the treatment target living tissue, and a control unit configured to control the treatment high-frequency wave output unit on the basis of the result of the detection in the detection unit, the control unit configured to set a treatment frequency of the treatment high-frequency wave to a first treatment frequency in order to treat the living tissue primarily by Joule heat when the impedance of the treatment target living tissue is lower than a threshold value and to set the treatment frequency to a second treatment frequency higher than the first treatment frequency in order to treat the living tissue primarily by high-frequency dielectric heating when the impedance of the treatment target living tissue is higher than the threshold value.

Abstract: Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.

Abstract: In order to make available a wound dressing (100) with at least one energy transfer agent (11, 12) and a wound dressing (13), namely a combination of wound dressing and electrode for the stimulation treatment, with which an uniform electrostimulation of the wound can be achieved so that the wound healing process is considerably improved, it is proposed that the energy transfer agent has at least two layers and that the energy transfer agent (11, 12) has at least two adjacent layers (11, 12), a first layer (11)—energy supply—and a second energy—distribution of energy—(12), whereby the first layer (11) has a lower electric resistance and the second layer (12) a higher electric resistance.

Abstract: According to some embodiments, a method for improving functional recovery after cerebro-vascular accidents, such as strokes, in humans and animals comprises stimulating a cranial nerve with electrical current. According to some embodiments, a method for improving functional recovery after stroke in a human or animal in need thereof comprises applying to the cranial nerve of the human or animal a stimulating electrical signal that causes neurophysiological, morphological, chemical, or neuronal connective alteration in the brain, where the alteration changes neural function in the brain so as to change functional recovery and functional dynamics in the human or animal. According to some embodiments, a method for improving functional recovery after stroke in a human or animal in need thereof comprises applying to a first cranial nerve a first stimulating electrical signal optimized so as to promote stroke recovery.

Abstract: A disposable electrical stimulation device and method for providing therapeutic treatment and pain management in a convenient, compact configuration. Electrode size and shape and relative configuration can be varied according to an intended application and use, or a universal configuration can be provided for use on almost any area of the body. The common structure of communicatively coupled dual electrodes including control circuitry and a power source accommodates a range of different sizes, configurations, stimulation treatment intensities, and other physical and electrical characteristics that can be pre-customized and packaged for specific, limited time use. The device can therefore be used in methods of providing therapy, managing pain, and achieving other treatment goals by electrical stimulation.

Abstract: The method and device of the present invention for pain relief using ultrasound waves in combination with cryogenic energy includes a generator and a transducer to produce ultrasonic waves and a cryogenic source to produce cryogenic energy. Ultrasound waves are delivered to the target in combination with cryogenic energy. Ultrasound waves and cryogenic energy can be delivered to the target from the radial side of the ultrasound horn and/or tip or can be delivered from the distal end of the ultrasound tip. Cryogenic energy can also be delivered directly to the target through a central orifice. Ultrasound energy can also be delivered through a cryogenic spray at the distal end. The use of ultrasound waves in combination with cryogenic energy can provide an analgesic effect.

Abstract: A method and system of providing biological distance-treatment through a public network includes at least a treatment instrument which is electrically connected with an information connection system for providing a treatment for a registered user, wherein a treatment information data package sent from a service provider via the information connection system through the public network to provide digital treatment signals to control the treatment, wherein the treatment information data package is selected from the treatment information database based on a treatment request sent from the information connection system to the service provider and the health information profile of the registered user in the service provider.

Abstract: In one embodiment, a method includes implanting an implant entirely under the subject's skin. The implant includes a passive electrical conductor of sufficient length to extend from subcutaneous tissue located below one of a surface cathodic electrode and a surface anodic electrode to the tibial nerve. The surface electrodes are positioned in spaced relationship on the subject's skin, with one of the electrodes positioned over the pick-up end of the electrical conductor such that the portion of the current is transmitted through the conductor to the tibial nerve, and such that the current flows through the tibial nerve and returns to the other of the surface cathodic electrode and the surface anodic electrode. An electrical current is applied between the surface cathodic electrode and the surface anodic electrode to cause the portion of the electrical current to flow through the implant to stimulate the tibial nerve.

Abstract: A grooved electrode adapted for interfacing cellular matter is provided. The grooved electrode includes grooves adapted for electrically interfacing the grooved electrode with cellular matter growing along the body of the grooved electrode. Further, the grooved electrode includes a wireless transponder adapted to electrically interface with cellular matter and to relay such interactions via RF signals. The RF signals received by the wireless transponder are modulated in response to electrical signals generated by the cellular matter, which are detected by the transponder. The grooved electrode may be implanted within peripheral nerves for treating various neurological conditions, which may include nerve rehabilitation and prosthetic actuation, severe pain, obstructive sleep apnea and so forth.

Abstract: A portable applicator for pulsating signal therapy comprises a support body (10), and at least two signal-generating arrangements (30) that are arranged in or on the support body (10). The at least two signal-generating arrangements (30) are connected in series, and each of the at least two signal-generating arrangements (30) comprises at least two signal-generating units (20), which are connected in parallel.

Abstract: Methods for the treatment of CNS damage are described, and include inducing in a subject in need of such treatment, a therapeutically effective amount of functional electronic stimulation (FES) sufficient to evoke patterned movement in the subject's muscles, the control of which has been affected by the CNS damage. The induction of FES-evoked patterned movement at least partially restores lost motor and sensory function, and stimulates regeneration of neural progenitor cells in the subject patient.

Abstract: Provided is the combined use of pulsating electromagnetic signals and dose of Botulinum toxin to treat patients suffering from osteoporosis. Also provided is the use of electromagnetic signals generated by pulsating, impulse-modulated direct current for the treatment of osteoporosis.

Abstract: Methods of treating osteoarthritis include applying at least one stimulus to a stimulation site within a patient with an implanted system control unit in accordance with one or more stimulation parameters. Systems for treating osteoarthritis include a system control unit configured to apply at least one stimulus to a stimulation site within a patient in accordance with one or more stimulation parameters.

Abstract: An apparatus (500) for stimulating axon growth of the nerve cells in the spinal cord of mammals to stimulate regeneration of the nerve cells in the spinal cord. Such an apparatus includes a variable current DC stimulus generator (420), and data transfer circuitry (410) in communication with the DC stimulus generator (420) and an external module (430), the data transfer circuitry (410) operable to transmit signals between the DC stimulus generator (420) and the external module (430). The DC stimulus generator (420) and data transfer circuitry (410) may be within a biocompatible container (510).

Abstract: The present invention relates to methods of preventing, managing and/or treating blood sugar disorders, particularly those related to diabetes, by stimulating pancreas externally and non-invasively. Therapeutically repairing and regenerating beta cells of islets of langerhans enhance their ability to produce insulin to treat high blood sugar. The transformation of insensitive or impaired islets of langerhans results in an increased insulin secretion and in increased insulin level in blood plasma. This improves the glucose toxicity and improves beta cells dysfunction. This also regulates the pancreatic secretion that induces a feeling of satiety, which leads to weight loss.

Abstract: A method and apparatus include a therapeutic or developmental instrument that includes hardware and/or software for stimulating a muscle. Such an instrument may comprise, for instance, a golf club, a baseball bat, a lacrosse stick, a tennis racquet or a hockey stick, among other sports-related instruments. Still other suitable instruments may include a writing instrument, such as a pen. In the case of a golf club, a muscle of a user may be stimulated by the instrument as the golfer practices her swing. Combining such muscle stimulation with the act of practicing the movement of the swing has a synergistic effect of training the muscle as it builds strength. Similarly, a partial paralytic may regain strength in their hand by holding and writing with a pen configured to transcutaneously deliver a stimulating signal. Where desired, the instrument may include at least one electrode configured to deliver a stimulating signal to the holder of the instrument.

Abstract: A dressing support comprises a supporting element arranged for adhering in a removable manner to a skin portion of a patient, a dressing element, an electrode arrangement, the dressing element and the electrode arrangement being arranged in the supporting element in such a way as to be able to come into contact in use with the skin portion, and a window obtained in the supporting element near the dressing element.

Abstract: An electrical epidermal stimulation device for treating skin ailments having a power supply configured to provide power to the electrical epidermal stimulator, a first and second electrode configured to provide an electrical stimulus to an area of application, a wake up module configured to wake up a control module when a current flows from the first electrode to the second electrode, a voltage step generator module configured to generate a voltage, and an output drive module configured to control a direction of the voltage step to the first and second electrodes. In one embodiment, the electrical epidermal stimulation device comprises an indicator module for notifying a user that the device is functioning. In another embodiment, the voltage step generator module provides a voltage that increases and decreases in predetermined amounts to create a voltage step. In another embodiment, the direction of voltage application switches between the first and second electrodes.

Abstract: A device for carrying out a cosmetic method or treating skin ageing and the method comprising the following steps: a) connecting an electronic device, able to generate high frequency electric current waves having a distorted sinusoidal wave form by the presence of harmonics, to one or more electrodes of essentially laminar shape; b) applying said one or more electrodes on the skin surface in the area to be treated; c) activating said electronic device in order to transfer said current waves to said one or more electrodes and to maintain said device activated for a predetermined time; d) deactivating said device and removing the electrodes form the contact with the treated area.

Abstract: Methods for treating and/or collecting information regarding neurological disorders, including language disorders. A method in accordance with one embodiment directing a patient to perform a language-based task, directing information to be collected, with the information corresponding to a level of neural activity in the patient's brain while the patient performs the language-based task, and, based at least in part on the information, selecting a stimulation site within the patient's skull for receiving an electrode coupleable to an electrical current. In further embodiments, at least one electrode can be placed at the stimulation site, and the patient's language disorder can be reduced by applying electrical stimulation directly to the stimulation site via the at least one electrode.

Abstract: Methods for inducing calcium mobilization in cells through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. The invention also provides a method of increasing intracellular calcium in cells through the application of nsPEFs. In one embodiment of the invention, the cells are human platelets, whereby activation and aggregation of the platelets is induced. Methods for treating an injury, trauma, or loss of blood in a subject, through the application of nsPEFs are also provided.

Abstract: Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.

Abstract: An apparatus for wireless electrical stimulation of a neural injury includes a first electronic implant (102) is configured to generate a first potential difference relative to a body of a patient and a second electronic implant (104) configured to generate a second potential difference relative to the body of the patient. The second potential has a polarity opposite the polarity of the first potential difference. The second electronic implant (104) is configured to be wirelessly communicatively coupled and electrically coupled to the first electronic implant (102) when spaced apart therefrom in the body of a patient.

Abstract: A non-invasive tissue oxygenation system for accelerating the healing of damaged tissue and to promote tissue viability is disclosed herein. The system is comprised of a lightweight portable electrochemical oxygen concentrator, a power management system, microprocessors, memory, a pressure sensing system, a temperature monitoring system, oxygen flow rate monitoring and control system, a display screen and key pad navigation controls as a means of providing continuous variably controlled low dosages of oxygen to a wound site and monitoring the healing process. A kink resistant oxygen delivery tubing, whereby the proximal end is removably connected to the device and the distal end with holes or a flexible, flat, oxygen-permeable tape is positioned on the wound bed as a means of applying oxygen to the wound site. The distal end of the tube is in communication with the electrochemical oxygen concentrator and wound monitoring system to communicate temperature and oxygen partial pressure information.

Abstract: Methods and equipment used to regenerate sensory, motorial, or visceral signals of injured, broken or diseased nerves of mammalia, such as humans, are provided. In some embodiments, a lineup of downward and upward channels to bridge injured neural channels is disclosed. The downward or upward channels can be connected to electrodes which are in contact with upper or lower nerve stumps. The channels can be used to detect, amplify, and recognize the motorial or sensory signals, to generate related Functional Electrical Stimulation (FES) signals, and to supply the FES signals to the electrodes on the lower or upper nerve stumps. Neural signals can thus be regenerated and the injured motorial or sensory channels can be bridged.

Abstract: A biofeedback electronic stimulation device includes a processor for generating a first control signal and a plurality of second control signals responsive to at least one input signal. Transformer circuitry generates a stimulation signal including packets of at least one pulse responsive to the first control signal. Pulse circuitry configures the at least one pulse in the packet to a selected one of a plurality of configurations responsive to the plurality of second control signals. Output electrodes apply the at least one pulse in the packet to a user and detector circuitry detects zero crossings of the at least one pulse in the packet. The processor further causes generation of an indicator responsive to the detected zero crossings.

Abstract: The invention provides an implant, system and method for electrically stimulating a target tissue to either activate or block neural impulses. The implant provides a conductive pathway for a portion of electrical current flowing between surface electrodes positioned on the skin and transmits that current to the target tissue. The implant has a passive electrical conductor of sufficient length to extend from subcutaneous tissue located below a surface cathodic electrode to the target tissue. The conductor has a pick-up end which forms an electrical termination having a sufficient surface area to allow a sufficient portion of the electrical current to flow through the conductor, in preference to flowing through body tissue between the surface electrodes, such that the target tissue is stimulated to either activate or block neural impulses. The conductor also has a stimulating end which forms an electrical termination for delivering the current to the target body tissue.

Abstract: A method of determining the voltage and current required for the application of specific and selective electric and electromagnetic signals to diseased articular cartilage in the treatment of osteoarthritis, cartilage defects due to trauma or sports injury, or used as an adjunct with other therapies (cell transplantation, tissue-engineered scaffold, growth factors, etc.) for treating cartilage defects in the human hip joint and a device for delivering such signals to a patient's hip. Anatomic, analytical, and planar circuit models are developed to determining the impedances, conductivities, and current flows in the human hip joint and its surrounding soft tissues and skin that are required to produce a 20 mV/cm electric field in the synovium and articular cartilage of the human hip. The voltage of the signal applied to the surface electrodes or to a coil(s) or solenoid is varied based on the size of the hip joint; larger hip joints require larger voltages to generate the effective electric field.

Abstract: A hair restoration apparatus includes an electrical generator configured to generate an electrical signal meeting defined characteristics. A controller in operative communication with the generator controls operation of the generator and characteristics of the generated electrical signal selected to effect a therapeutically effective application of electrical signals to a hair restoration site. An electrode in electrical communication with the electrical generator is disposed in an area where application of the electrical signal is desired. An electrical connection between the electrical generator and the electrode is provided and sealed for at least partial implantation under the skin of a patient in selected embodiments.

Abstract: The present invention provides a method for enhancing regeneration of the myocardium. The method comprises the steps of applying electrical stimulation to an injury site in the myocardium. The method can be used in combination with implantation of myogenic cells into the injury site. The electrical stimulation may be applied before or after the implantation.

Abstract: Methods and devices for the regulation of gene expression in tissue by applying an electric and/or electromagnetic field generated by specific and selective signals so as to treat diseases, conditions, and/or tissue. Gene expression is the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are described for the regulation of Vascular Endothelial Growth Factor (VEGF) protein gene expression in endothelial cells of various targeted tissues via the capacitive coupling or inductive coupling (e.g., by electrodes or one or more coils or other field generating devices disposed with respect to the targeted cells) of specific and selective signals to the cells of these tissues, where the resultant electric and/or electromagnetic fields treat diseased or injured tissues.

Abstract: Embodiments include electromagnetic energy-based tissue treatment devices which comprise biometric sensors in combination with memory storing biometric data from authorized treatment providers, and methods of restricting use of the devices based on comparing biometric data from potential treatment providers to the stored biometric data from authorized treatment providers. Delivery of a treatment can be permitted when the biometric data from a potential treatment provider is found to match the biometric treatment data for an authorized treatment provider. The devices of the invention can further be configured to collect usage data and usage setting of the device, and usage data can be used in conjunction with biometric data to determine whether or not an authorized user has exceeded or will exceed a recommended treatment regimen.

Abstract: Methods and devices are described for the regulation of Transforming Growth actor (TGF)-?1, ?2, and/or ?3 protein gene expression in bone cells and other tissues via the capacitive coupling or inductive coupling of specific and selective electric fields to the bone cells or other tissues, where the specific and selective electric fields are generated by application of specific and selective electric and electromagnetic signals to electrodes or one or more coils or other field generating device disposed with respect to the bone cells or other tissues so as to facilitate the treatment of diseased or injured bone and other tissues. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein.