Ligament Or Tendon Patents (Class 623/13.11)
  • Patent number: 11351288
    Abstract: An artificial ligament prosthesis which is notable in that it comprises a layer totally or partly consisting of PCL fibres. The ligament prosthesis is a biodegradable and “biointegrable” artificial ligament which makes it possible to take away all the apprehensions and uncertainties due to non-degradable synthetic supports. It is a prosthetic structure inspired by and similar to the native tissue, which is biodegradable while being sterilisable. It can optionally be seeded in order to facilitate the formation of functional tissues with controlled cell and tissue activity, having the required mechanical properties. The prosthesis maybe slowly resorbable in order to be gradually replaced with a functional tissue identical to that of the native ligament.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: June 7, 2022
    Assignee: L.A.R.S.—LABORATOIRE D'APPLICATION ET DE RECHERCHE SCIENTIFIQUE
    Inventors: Bernard Brulez, Véronique Migonney, Roger Guilard
  • Patent number: 11241305
    Abstract: Methods and apparatuses for repairing a tear in soft tissue are disclosed. A method according to the principles of the present disclosure includes connecting an intermediate member to a bone anchor and placing the intermediate member on the soft tissue. The method further includes inserting a first suture through the intermediate member and the soft tissue to attach the intermediate member to the soft tissue and fixing the bone anchor to bone to secure the soft tissue to the bone.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: February 8, 2022
    Assignee: Biomet Sports Medicine, LLC
    Inventors: Gregory J. Denham, Brian K. Berelsman
  • Patent number: 11109854
    Abstract: A method of reinforcing a biological construct according to an exemplary aspect of the present disclosure includes, among other things, attaching a suture loop/needle construct to a reinforcement material and stitching the reinforcement material to a biological construct to form a reinforced biological construct. The reinforcement material is attached to the suture loop/needle construct prior to approximating the reinforcement material to the biological construct.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: September 7, 2021
    Assignee: ARTHREX, INC.
    Inventors: James J. Guerra, Jacob A. Jolly, Dustin T. Libby, Thomas M. Deberardino
  • Patent number: 11076845
    Abstract: Methods and devices for the repair of a ruptured ligament using a scaffold device are provided. Aspects of the invention may include a scaffold attached by a suture to an anchor. In aspects of the invention, the anchor may be secured to a bone near or at the repair site.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: August 3, 2021
    Assignee: The Children's Medical Center Corporation
    Inventor: Martha M. Murray
  • Patent number: 10973622
    Abstract: A reconstruction system and associated techniques for soft tissue repairs and repair augmentation. The reconstruction system is an internal soft tissue brace formed of at least one fixation device (for example, anchors or screws) and a replacement/reinforcement construct (for example, a suture construct in the form of a suture tape such as FiberTape® or a collagen tape or a suture with biological material or a collagen coated material, or a collagen patch, or a biological construct such as Arthroflex). The reinforcement construct and fixation devices may be used as a suture repair alone (to replace the ligament or tendon), or in conjunction with other traditional soft tissue repair procedures, acting as a reinforcement system for the repaired soft tissue.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: April 13, 2021
    Assignee: ARTHREX, INC.
    Inventor: Gordon M. Mackay
  • Patent number: 10918489
    Abstract: A medical device for implantation in a hip joint of a patient is provided. The medical device comprises a prosthetic caput femur having least partially spherical portion and a releasing member. The releasing member is adapted to, in a first state, restrain the at least partially spherical portion in an acetabulum or a prosthetic acetabulum and, in a second state, to release the at least partially spherical portion from the acetabulum or the prosthetic acetabulum. The releasing member is further adapted to change from the first state to the second state and from the second state to the first state when a strain, exceeding a predetermined threshold, is exerted on the hip joint.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: February 16, 2021
    Inventor: Peter Forsell
  • Patent number: 10786239
    Abstract: Methods and devices for the repair of a ruptured ligament using a scaffold device are provided. Aspects of the invention may include a scaffold attached by one or more sutures to one or more anchors. In aspects of the invention, the anchors may be secured to a bone near or at the repair site.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: September 29, 2020
    Assignee: The Children's Medical Center Corporation
    Inventor: Martha M. Murray
  • Patent number: 10702398
    Abstract: An apparatus and a method are provided for performing cartilage graft implant surgeries. The apparatus comprises a graft plug kit comprising one or more grafts configured to treat osteochondral defects in various bone joint locations in a patient's body. Each of the grafts comprises a cartilage layer coupled with a bone portion. The cartilage layer comprises a thickness selected to closely match the thickness of existing cartilage at an implant location. The bone portion comprises surface features configured to encourage the patient's bone tissue to grow into the bone portion, thereby accelerating incorporation of the graft into the patient's bone. An instrument kit comprises a multiplicity of instruments configured for implantation of the grafts into the patient's body, including at least a graft inserter, a guidewire, a reamer, and a size gauge.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: July 7, 2020
    Assignee: In2Bones USA, LLC
    Inventor: Rebecca Hawkins Wahl
  • Patent number: 10687952
    Abstract: A flexible, cannulated bone implant includes a proximal stem having a proximal end, a distal end, and a proximal conduit extending from the proximal end to the distal end of the proximal stem, a distal stem having a proximal end, a distal end, and a distal conduit extending from the proximal end to the distal end of the distal stem, and a flexible hinge interconnecting the distal end of the proximal stem with the proximal end of the distal stem for allowing the proximal and distal stems to flex relative to one another. The implant includes a proximal stem protective tube disposed within the proximal conduit of the proximal stem, and a distal stem protective tube disposed within the distal conduit of the distal stem. An elongated pin extends through the distal stem protective tube disposed within the distal stem and the proximal stem protective tube disposed within the proximal stem for securing the implant to bone.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: June 23, 2020
    Inventor: Russell D. Petranto
  • Patent number: 10675142
    Abstract: A tissue fixation device for securing soft tissue to bone includes an expandable outer sheath, and an inner screw in threaded cooperation with the sheath. The expandable sheath comprises opposing walls in hinged engagement. When the screw is inserted into in the sheath, the walls pivot outwardly about a distal hinge to compress a tissue graft against the bone hole, and to lock the device therein. An optional cortical button is secured across the bone hole entrance, and tethered to the fixation device to bolster fixation.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: June 9, 2020
    Assignee: MV N8TIVE, LLC
    Inventors: David Gregoire, George White, Christopher Rodriguez, Mark Harrold
  • Patent number: 10609922
    Abstract: The present invention relates to the use of polysulfated polysaccharides in combination with progenitor cells to improve the viability of the progenitor cells including improving the cryopreservation of the progenitor cells and provides novel compositions, methods and uses. The present invention also relates to the use of polysulfated polysaccharides to regulate the proliferation and differentiation of progenitor cells.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: April 7, 2020
    Assignee: Proteobioactives Pty Ltd
    Inventor: Peter Ghosh
  • Patent number: 10448943
    Abstract: A method of reinforcing a biological construct according to an exemplary aspect of the present disclosure includes, among other things, attaching a suture loop/needle construct to a reinforcement material and stitching the reinforcement material to a biological construct to form a reinforced biological construct. The reinforcement material is attached to the suture loop/needle construct prior to approximating the reinforcement material to the biological construct.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: October 22, 2019
    Assignee: ARTHREX, INC.
    Inventors: James J. Guerra, Jacob A. Jolly, Dustin T. Libby, Thomas M. Deberardino
  • Patent number: 10426871
    Abstract: Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed. The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: October 1, 2019
    Assignees: The Regents of the University of California, The Penn State Research Foundation
    Inventors: Tejal A. Desai, Ketul C. Popat, Craig A. Grimes
  • Patent number: 9888996
    Abstract: The disclosure describes implantable medical products, that include dry or partially hydrated biocompatible constructs comprising collagen fibers configured to expand in situ after implantation to frictionally engage a bone tunnel wall to thereby affix the construct in the bone tunnel.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: February 13, 2018
    Assignee: Shriners Hospitals for Children
    Inventors: Thomas J. Koob, Douglas Pringle
  • Patent number: 9848988
    Abstract: A medical device for implantation in a hip joint of a patient is provided. The medical device comprises a first and second piece and a releasing member adapted to, in a first state hold the first piece attached to the second piece, and in a second state release the first piece from the second piece. The releasing member is adapted to change from the first state to the second state when a pre-determined strain is placed on the releasing member.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: December 26, 2017
    Inventor: Peter Forsell
  • Patent number: 9770532
    Abstract: A bone implant matrix for human or veterinary use, the matrix including a base matrix either treated or to be treated with a reinforcing mixture containing at least a polymer. The bone implant matrix is particularly adapted for use in bone reconstructive surgery, maxillo-facial bone reconstructive surgery and oral surgery.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: September 26, 2017
    Assignee: INDUSTRIE BIOMEDICHE INSUBRI S/A
    Inventor: Gianni Pertici
  • Patent number: 9655612
    Abstract: A method of forming a suture tape assembly having a visually distinguishable midpoint includes weaving a longitudinally central portion of a length of round suture material together with other strands of material to form a length of suture tape. This suture tape has a longitudinal first end and a longitudinal second end, and the length of round suture material extends from both the first end and second end. Next, a center part of the length of the round suture material is grasped and pulled outwardly from the suture tape, to form a partial loop extending outwardly from the suture tape. This partial loop is cut from the suture tape, thereby leaving a longitudinally medial segment of the suture tape without the round suture material, and thereby being made visibly distinguishable from neighboring suture tape, which includes the round suture material.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: May 23, 2017
    Assignee: RIVERPOINT MEDICAL, LLC
    Inventors: Patrick Edward Ferguson, Patrick Joseph Ferguson
  • Patent number: 9636209
    Abstract: The disclosure describes implantable bioprosthesis and constructs having an implantable woven ribbon with at least one integrated suture.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: May 2, 2017
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Mengyan Li
  • Patent number: 9636203
    Abstract: An inguinal hernia prosthesis includes a cord locating structure that provides cord protecting functions. The cord locating structure, which may be a semi-circular or other shaped recess positioned along a longitudinal peripheral edge of the prosthesis, is designed to only surround a portion of the cord, e.g. less than 180 or preferably 120 degrees, with the remaining cord circumference being positioned by the element against appropriate muscle tissue. The cord locating structure may be referenced as a non-encircling lateral cord locating structure. The prosthetic: provides tension free repair; minimizes cord damage through tissue ingrowth/strangulation effects, inadvertent suturing through the cord structure, and abrasion with the prosthetic; and minimizes size of prosthetic used in the repair; and is configured to reconstitutes the pre-hernia muscle physiology.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: May 2, 2017
    Inventor: Enrico Nicolo
  • Patent number: 9597125
    Abstract: Spinal stabilization devices, systems, and methods are described. Foramenal spacers including a rigid member adapted to maintain the integrity of the foramenal space. Facet joint stabilizing members and prosthetic facet joints that augment or replace the native facet joint are also described. Lateral spinal stabilization systems that may be attached to the lateral surfaces of adjacent vertebral bodies are described. Also described are anterior spinal stabilization systems that are to be attached to the anterior surfaces of adjacent vertebral bodies. Several variations of dynamic spinal stabilization devices and systems are described. Each of the foregoing devices, systems, and methods may be used independently, in combination with the other devices, systems, and methods described herein, and/or in combination with prosthetic intervertebral discs.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: March 21, 2017
    Assignee: SPINAL KINETICS, INC.
    Inventor: Darin C. Gittings
  • Patent number: 9554895
    Abstract: A scaffold for reshaping the cartilaginous portion of an ear. The scaffold is formed of shape memory material and in the form of a horseshoe shape, or is formed from a thermoplastic pliable material.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: January 31, 2017
    Assignee: Northwood Medical Innovation Limited
    Inventors: Norbert Kang, Marie-Claire Haines
  • Patent number: 9393104
    Abstract: A tendon repair implant for treatment of a partial thickness tear in the supraspinatus tendon of the shoulder is provided. The implant may incorporate features of rapid deployment and fixation by arthroscopic means that compliment current procedures; tensile properties that result in desired sharing of anatomical load between the implant and native tendon during rehabilitation; selected porosity and longitudinal pathways for tissue in-growth; sufficient cyclic straining of the implant in the longitudinal direction to promote remodeling of new tissue to tendon-like tissue; and, may include a bioresorbable construction to provide transfer of additional load to new tendon-like tissue and native tendon over time.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: July 19, 2016
    Assignee: Rotation Medical, Inc.
    Inventors: Craig Van Kampen, Nathaniel Zenz-Olson, Thomas A. Westling, Charles L. Euteneuer
  • Patent number: 9387280
    Abstract: Disclosed are composite implantable tissue attachment devices comprising a mechanical reinforcing component and a cellular scaffold component. Disclosed devices include a wide, relatively flat portion for supporting long term repair of tissue. Disclosed devices can include a tapered portion at the end of the wide portions that can lead into a narrower elongated extension for aiding in placement of the device during a surgical procedure. The wide portion of the device can provide tensile strength along the longitudinal axis of the device as well as porosity. The wide devices can cover a larger surface area of a delivery site than standard suture. Disclosed materials can be utilized in, e.g., soft tissue repair such as tendon and ligament reconstruction and repair.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: July 12, 2016
    Assignee: Synovis Orthopedic and Woundcare, Inc.
    Inventors: John Brunelle, Al Weinstein
  • Patent number: 9308219
    Abstract: A flat self-curling permeable sheet membrane containing a matrix formed of crosslinked biopolymeric fibers. The matrix self-curls into a predetermined shape upon absorption of an aqueous fluid and is permeable to molecules having molecular weights not greater than 1×106 daltons. Also disclosed is a method of preparing such a flat self-curling permeable membrane.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: April 12, 2016
    Assignee: Collagen Matrix, Inc.
    Inventors: Shu-Tung Li, Natsuyo Shishido Lee, Debbie Yuen
  • Patent number: 9161785
    Abstract: Methods and apparatus provide for coupling an elongate guide substantially at a first end to at least one vertebral body of a spinal column of a patient; and extending a second end of the guide to a structure of the patient spaced in an anterior direction away from the at least one vertebral body towards an entry incision.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: October 20, 2015
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Mickey Dean Morgan, John Henry Peloza, Randall Feldman Lee
  • Patent number: 9144483
    Abstract: A fixation device can be delivered to the body of a patient by coupling the fixation device to a delivery instrument at a head of the fixation device. Engaging the fixation device to the delivery instrument at the fixation device's head allows the fixation device to be secured to a tissue and/or ligament of the patient. The fixation device can be a sling for placement around the bladder neck of a female patient.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: September 29, 2015
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Michael S. H. Chu
  • Patent number: 9125971
    Abstract: The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 8, 2015
    Assignee: LifeNet Health
    Inventors: Lloyd Wolfinbarger, Jr., Robert K. O'Leary, Billy G. Anderson
  • Patent number: 9017404
    Abstract: Disclosed is a device and method for repairing a partially or totally ruptured tendon. The device comprises an implant placed inside or outside of the tendon on either side of the rupture in order to strengthen the ruptured area during repair. Once positioned inside the tendon, the tendon is held in place so it can heal either by sewing or stapling through the tendon and implant, or by any other suitable method that utilizes the implant to provide strength to the ruptured area. In this manner the tendon can heal with less chance of rupturing again prior to healing.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: April 28, 2015
    Inventors: Lloyd P. Champagne, Jozef Zoldos
  • Patent number: 9011533
    Abstract: Anterior cruciate ligament reconstruction methods and devices are designed to achieve an anatomically accurate double bundle anterior cruciate ligament reconstruction by using a single femoral and tibial tunnel. The method and devices reconstruct the two bundles of the anterior cruciate ligament in a single femoral and tibial tunnel using a bone-patellar tendon-bone graft. The methods and devices enable an accurate anatomical reconstruction of the anteromedial and posterolateral bundles by creating a single femoral and tibial tunnel as opposed to creating two tunnels in the tibia and femur.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: April 21, 2015
    Assignee: The General Hospital Corporation
    Inventors: Hemanth R. Gadikota, Thomas J. Gill, Guoan Li
  • Patent number: 9011535
    Abstract: Methods and devices are provided for fixing a ligament graft in a bone tunnel. In general, the methods and devices involve affixing a ligament graft within a bone tunnel using an adhesive. A fixation device can be inserted through the ligament graft in a direction transverse to an axis of the tunnel to maintain the ligament graft in contact with the adhesive. The fixation device can be removed when the adhesive is cured such that the ligament graft is fixed in the tunnel.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: April 21, 2015
    Assignee: DePuy Mitek, LLC
    Inventor: Gregory R. Whittaker
  • Patent number: 9005285
    Abstract: Medical delivery devices include a needle and a flexible compressible impermeable tube attached to the needle. The compressible tube has an open interior channel. The device is adapted to releasably hold a length of a medical implant in the open interior channel of the tube. The medical implant can be slidably inserted into the interior channel of the tube and is loosely held by the tube.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: April 14, 2015
    Assignee: MiMedx Group, Inc.
    Inventors: Mei Niu, Daniel Hernandez, Thomas J. Koob
  • Patent number: 8986378
    Abstract: The invention relates to implantable collagen devices made by seeding at least one elongate collagen construct, e.g., comprising at least one elongate synthetic collagen fiber with a plurality of cells and applying a strain and/or stress to the at least one elongate collagen fiber to induce the cells to differentiate into target phenotypes, e.g., tendon or ligament phenotype cells (and/or fibroblasts), typically with an extracellular matrix of collagen to organize into a tissue on the at least one collagen fiber.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: March 24, 2015
    Assignee: MiMedx Group, Inc.
    Inventor: Thomas J. Koob
  • Patent number: 8961604
    Abstract: A fixation implant and associated methods are presented. The fixation implant includes a shaft extending from a first end portion to a second end portion and having an intermediate portion therebetween. The intermediate portion is generally smooth and the end portions are threaded. The method includes use of the fixation implant for repair of a metapodial phalangeal joint of a human extremity. The method includes: forming a bone tunnel in a bone; approximating material near the bone tunnel; and threading the fixation implant into the bone tunnel in interference fashion to secure the material relative to the bone tunnel. The fixation implant may be cut such that the end portion is flush with the bone.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: February 24, 2015
    Assignee: Smith & Nephew, Inc.
    Inventors: T. Wade Fallin, M Mary Sinnott
  • Patent number: 8945536
    Abstract: Disclosed is a cell sheet for tissue repair and bio-artificial tissue engineering. The cell sheet comprises treated stem cell embedded in its self-secreted extracellular matrix (ECM) and formed a cell sheet. The cell sheet is formed by isolating the stem cell, expanding the stem cell and treating the stem cell with biological factors or factors leading to the production of biological factors, to induce its differentiation, production of extracellular matrix and formation of a cell sheet in vitro. The cell sheet is used as a bioactive material or as an acellular material for the promotion of tissue repairs or used to form a bio-artificial organ for tissue replacement. The cell sheet of the present invention eliminates the need to use scaffolds for cell delivery. The cell sheet facilitates in vivo cell transplantation and provides some tensile mechanical strength for bearing early mechanical load during tissue repair.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: February 3, 2015
    Assignee: The Chinese University of Hong Kong
    Inventors: Po Yee Pauline Lui, Ming Ni, Yunfeng Rui
  • Patent number: 8945218
    Abstract: Degradable, polymeric fiber-based, three-dimensional braided scaffolds for use as graft materials in ligament and tendon repair, reconstruction and replacement are provided. Also provided are methods for preparing these scaffolds.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: February 3, 2015
    Assignee: Drexel University
    Inventors: Cato T. Laurencin, Frank K. Ko, James A. Cooper, Helen H. Lu, Mohammed A. Attawia
  • Publication number: 20150012092
    Abstract: The present invention relates to a novel composition comprising carbon nanotubes and/or graphene and a supporting material that can be used as an implant, patch or construct for the treatment, repair or replacement of biological tissue, including musculoskeletal tissue, fascia tissue, dura tissue, epidermal tissue, blood vessels and arteries, and organs. The present invention is also a method of manufacturing the novel composition, and a method of using the novel composition to treat, repair or replace biological tissue.
    Type: Application
    Filed: September 12, 2014
    Publication date: January 8, 2015
    Inventors: Joshua Schroeder, Frank P. Cammisa, JR.
  • Publication number: 20140371853
    Abstract: A tendon repair implant for treatment of a partial thickness tear in the supraspinatus tendon of the shoulder is provided. The implant may incorporate features of rapid deployment and fixation by arthroscopic means that compliment current procedures; tensile properties that result in desired sharing of anatomical load between the implant and native tendon during rehabilitation; selected porosity and longitudinal pathways for tissue in-growth; sufficient cyclic straining of the implant in the longitudinal direction to promote remodeling of new tissue to tendon-like tissue; and, may include a bioresorbable construction to provide transfer of additional load to new tendon-like tissue and native tendon over time.
    Type: Application
    Filed: September 2, 2014
    Publication date: December 18, 2014
    Inventors: Craig Van Kampen, Nathaniel Zenz-Olson, Thomas A. Westling, Charles L. Euteneuer
  • Patent number: 8901078
    Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: December 2, 2014
    Assignee: Harbor Medtech, Inc.
    Inventors: W. Jerry Mezger, Keith E. Myers
  • Patent number: 8900301
    Abstract: A device for surgically coupling a soft tissue graft into a tunnel of a bone. The device includes a first member and a second member. The first member includes a first graft-engaging surface extending from a first end to a second end of the first member. The second member includes a second graft-engaging surface extending from a first end to a second end of the second member. The first graft-engaging surface and the second graft-engaging surface define a graft-accepting through-passage with a longitudinal axis extending therethrough when the first member is secured to the second member.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: December 2, 2014
    Assignee: Biomet Sports Medicine, LLC
    Inventors: Kevin T. Stone, Jason D. Meridew
  • Publication number: 20140350675
    Abstract: The invention relates to an implantable prosthetic device for the repair of connective tissue in an animal or a human. In one embodiment, an implantable prosthetic device (100) for the repair of connective tissue (500) in an animal or human is disclosed which comprises a biocompatible pad (101) having an open structure to provide a scaffold for the in-growth of tissue into the pad; and a reinforcement region (206) attached to or formed integrally with the pad. The device is arranged so that it can be attached to tissue by forming a puncture (301) either a) within the reinforcement region, or b) in an area of the pad which is inboard of the reinforcement region, so that a suture (300) can be located through the puncture, the reinforcement region serving to support tensile loading in the device during use by resisting pull-through of the suture.
    Type: Application
    Filed: July 20, 2012
    Publication date: November 27, 2014
    Inventors: Roger Graham Hackney, David John Beevers, Lauren Tidball
  • Publication number: 20140350677
    Abstract: One aspect of the present invention is a method of producing a decellularized composite tissue bioscaffold for musculoskeletal tissue interface reconstruction by physicochemically treating a musculoskeletal tissue interface isolated from allogeneic sources. In certain embodiments, such musculoskeletal tissue interfaces can also be isolated from xenogeneic sources. The method comprises treatment of the interface with detergents, chemical oxidants and ultrasonic energy, and wash steps in between to remove residual detergents as well as oxidants. The resulting bioscaffold may be freeze-dried or lyophilized, sterilized and aseptically packaged for subsequent use.
    Type: Application
    Filed: December 7, 2012
    Publication date: November 27, 2014
    Inventors: James Chang, Colin Woon, Hung Pham
  • Patent number: 8894707
    Abstract: This document relates to methods and materials involved in tendon or ligament tissue engineering. For example, methods and materials for generating a composite of acellular tendon or ligament allograft slices seeded with cells and bundled into a graft for tissue repair are provided.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: November 25, 2014
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Chunfeng Zhao, Yu-long Sun, Steven L. Moran, Kai-Nan An, Peter C. Amadio
  • Patent number: 8888849
    Abstract: A method of repairing soft tissue of a joint of a human extremity, such as a hand or foot. The method includes maintaining a metapodial bone intact; inserting a suture passing instrument into a space adjacent the metapodial and phalangeal bones; passing the suture through a volar ligament near a distal end of the metapodial bone and reattaching the volar ligament to the proximal phalanx. The method also includes making an incision on the dorsal aspect of the extremity to expose the dorsal aspect; inserting the distal portion of the suture passer instrument through the incision on the dorsal aspect of the extremity; inserting the distal portion of the suture passing instrument into a tendon sheath connected to a volar plate; and passing a portion of a suture through the volar plate.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: November 18, 2014
    Assignee: Smith & Nephew, Inc.
    Inventors: T Wade Fallin, M. Mary Sinnott
  • Patent number: 8888848
    Abstract: Described herein are methods and devices for use in repair of a patient's anterior cruciate ligament (ACL). These methods (and devices for performing them) allow the repair, rather than merely replacement, of the ACL. For example, described herein are anchoring devices that may be inserted into a bone and may anchor a scaffolding/support (e.g., graft) material within the bone so that the torn or damaged end of the ACL may be secured to the scaffolding/support material within the femoral notch. These anchoring devices and method of using them are particularly well suited for use with the continuous suture passers described herein, since these suture passers may allow access to previously inaccessible regions of the knee (or other body regions).
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: November 18, 2014
    Assignee: Ceterix Orthopaedics, Inc.
    Inventors: Justin D. Saliman, Mark S. Colella
  • Patent number: 8882834
    Abstract: Methods and instruments for repairing soft tissues of a skeletal joint, such as, for example, of the foot or hand are presented. The method includes the steps of maintaining the metapodial bone intact; forming a bone tunnel through the proximal phalanx between volar and dorsal aspects of the proximal phalanx; passing a repair suture through the soft tissue to be repaired; passing the repair suture through the bone tunnel; and securing the suture. The method may be used for the repair of soft tissue, such as a volar ligament and/or a collateral ligament.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: November 11, 2014
    Assignee: Smith & Nephew, Inc.
    Inventors: M. Mary Sinnott, T. Wade Fallin, Kwan-Hp Chan, Patrick Michael White
  • Patent number: 8870954
    Abstract: The invention provides compositions and methods for treatment of tendon and ligament injuries and/or repair of damaged tendons and ligament. The invention provides compositions comprising a biocompatible matrix and platelet-derived growth factor (PDGF).
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: October 28, 2014
    Assignee: BioMimetic Therapeutics, LLC
    Inventors: Samuel E. Lynch, Leslie A. Wisner-Lynch, Hans K. Kestler, Yanchun Liu
  • Publication number: 20140309738
    Abstract: Collagen-glycosaminoglycan membrane shell scaffold core composites for connective tissue engineering that avoids aspects of the typical tradeoff between mechanical properties (i.e. modulus, failure strength) and bioactivity (i.e., permeability and porosity) for porous tissue engineering scaffolds. The relative density of the collagen glycosaminoglycan scaffold core can be about 0.5 to about 0.95 while the membrane shell can be about 0.001 to 25 about 0.2. The core-shell composite can be tubular and the composite can have a diameter of about 1 mm to about 20 mm. The collagen glycosaminoglycan membrane shell can be perforated with about 25 to about 1000 micrometers openings or alternatively can be embossed with any range of pattern features from about 25 to about 1000 micrometers in size. The porous collagen glycosaminoglycan scaffold core can be populated with cells such as adult or embryonic stem cells, tenocytes, osteoblasts, nerve cells, cardiac cells, myocytes, fibroblasts or combinations thereof.
    Type: Application
    Filed: June 1, 2012
    Publication date: October 16, 2014
    Inventors: Brendan A. Harley, Steven R. Caliari, Manuel Alejandro Ramirez Garcia
  • Patent number: 8858633
    Abstract: The disclosure describes implantable medical products, that include dry or partially hydrated biocompatible constructs comprising collagen fibers configured to expand in situ after implantation to frictionally engage a bone tunnel wall to thereby affix the construct in the bone tunnel.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: October 14, 2014
    Assignee: Shriners Hospital for Children
    Inventors: Thomas J. Koob, Douglas Pringle
  • Patent number: 8852214
    Abstract: Methods and systems are provided for fixating connective tissue to bone. Some aspects include a carrier member having a length, width, and thickness, wherein the length and width are each at least two times greater than the thickness; attachment members extending from the carrier member and that engage connective tissue of an animal; and a bone engaging member extending from the carrier member and configured to attach to a bone of the animal. In some aspects, when the attachment members are engaged with the connective tissue and the bone engaging member is attached to the bone, the connective tissue and the bone are limited in being pulled apart from one another during physiological use of the connective tissue.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: October 7, 2014
    Assignee: University of Utah Research Foundation
    Inventor: Erik N. Kubiak
  • Publication number: 20140277450
    Abstract: A surgical pin guide for reconstruction of a carpo-metacarpal (CMC) joint of a hand includes: a guide body having first and second opposed second end portions; a first pin receiving member connected to the first end portion of the guide body, the first pin receiving member having an elongated channel extending therethrough; and a second pin receiving member connected to the second end portion of the guide body, the second pin receiving member having an elongated channel extending therethrough. The first pin receiving member channel is sized and configured to receive a proximal end portion of a first pin that has a distal end portion residing in a trapezium of a hand. The second pin receiving member channel is sized and configured to receive and align a second pin for insertion into a first metacarpal of the hand.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Inventor: Mark J. Warburton