Including Natural Tissue Patents (Class 623/13.17)
  • Patent number: 10307510
    Abstract: Tissue products lacking a desired percentage of immunogenic epitopes, such as galactose alpha-1,3 galactose epitopes, are provided. Methods of making and using the tissue products are also provided.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: June 4, 2019
    Assignee: LifeCell Corporation
    Inventors: Hui Xu, Li Ting Huang, Hua Wan, Rick T. Owens, Nathaniel Bachrach
  • Patent number: 10182903
    Abstract: Systems and methods for preparing a ligament graft construct for a ligament reconstruction or repair procedure are provided. In general, the described techniques utilize a reinforcement material having at least one suture tail extending therefrom. The reinforcement material is a ribbon or a ribbon-like flattened portion attached to or integrally formed with the at least one suture tail. To prepare a tissue repair construct, the reinforcement material is positioned on a first surface of a graft to extend from an end thereof and the at least one suture tail, coupled to a needle, is repeatedly passed through the reinforcement material and the surface of the graft to a second surface of the graft, and around a side portion of the graft to thereby create multiple suture loops. The tissue repair construct can be formed on each end of the graft.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: January 22, 2019
    Assignee: DEPUY MITEK, LLC
    Inventor: Mehmet Z. Sengun
  • Patent number: 10119202
    Abstract: The presently disclosed subject matter provides a scalable and electrostretching approach for generating microfibers exhibiting uniaxial alignment from polymer solutions. Such microfibers can be generated from a variety of natural polymers or synthetic polymers. The hydrogel microfibers can be used for controlled release of bioactive agents. The internal uniaxial alignment exhibited by the presently disclosed fibers provides improved mechanical properties to microfibers, contact guidance cues and induces alignment for cells seeded on or within the microfibers.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: November 6, 2018
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Hai-Quan Mao, Shuming Zhang, Xi Liu, Brian Patrick Ginn
  • Patent number: 9693866
    Abstract: The present invention relates to a tasseled cortical bone graft and a method of preparing cortical bone in thin strips or tubes then fully demineralizing it to give it formed flexibility and then creating a plurality of strands extending from one or more connection locations in the cortical bone in a fashion similar to a tassel.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: July 4, 2017
    Assignee: Vivex Biomedical, Inc.
    Inventors: Harry Thomas Temple, Sonya A. Cooper
  • Patent number: 9622742
    Abstract: Systems and methods for preparing a tissue repair construct for a ligament reconstruction procedure using a reinforced whip-stitching are provided. The described techniques include passing a needle having suture tails attached thereto through a first surface of a graft at an origin point so that a portion of the suture tails exits on a second, opposite surface of the graft while a terminal length of the suture tails is maintained on the first surface of the graft. Multiple suture loops are formed by repeatedly passing the needle with the suture tails around opposite sides of the graft and through the first surface of the graft at subsequent entry points spaced apart along a length of the graft. Each loop is formed so that the construct is reinforced by having a terminal length of each of the suture tails disposed between the first surface of the graft and the loop.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: April 18, 2017
    Assignee: DePuy Mitek, LLC
    Inventor: David B. Spenciner
  • Patent number: 9603969
    Abstract: Provided are a scaffold material that functions as a scaffold material for two weeks or more in vivo and causes substantially no foreign-body reaction, and a method for producing the scaffold material. Specifically, a porous scaffold material comprising collagen fibers is provided.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: March 28, 2017
    Assignee: Kyoto University
    Inventors: Akira Nakada, Keiji Shigeno, Tatsuo Nakamura
  • Patent number: 9545315
    Abstract: Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: January 17, 2017
    Assignee: Globus Medical, Inc.
    Inventor: Mark Borden
  • Patent number: 9463206
    Abstract: Described herein are tissue grafts produced by contacting dehydrated placental tissue grafts with a cross-linking agent. The tissue grafts described herein provide barrier and prevent the migration of a bioactive agent from the wound. Thus, the tissue grafts enhance wound healing while preventing the undesirable migration of a bioactive agent from the wound. Methods for making and using the cross-linked grafts are also described herein.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: October 11, 2016
    Assignee: MiMedx Group, Inc.
    Inventors: Tom Koob, John Daniel, Randall Spencer
  • Patent number: 9308242
    Abstract: Methods and devices for the repair of articular tissue using collagen material are provided. Compositions of collagen material and related kits are also provided.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: April 12, 2016
    Assignee: Children's Medical Center Corporation
    Inventor: Martha M. Murray
  • Patent number: 9149354
    Abstract: A flexor tendon repair device has a sheet of mesh material of rectangular shape with four edges: two longitudinal edges and two lateral edges perpendicular to the longitudinal edges. Each pair of edges is mutually parallel and spaced apart. Each edge is also folded inwardly for two smooth edges upon which the healing tendon rests and two smooth edges where the sheet mutually joins. Along with the sheet, the invention includes sutures, typically doubled, and one at each lateral edge. The lateral edges generally support the healing tendon while the sheet wraps around the tendon with the longitudinal edges generally parallel to the length of the tendon. A surgeon, during use of the invention, tightens each suture along the longitudinal edges, closing the device, and then upon the laterals to tie the suture. Upon tying, the mesh attains an ovoid shape similar to the natural cross section of a tendon.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: October 6, 2015
    Inventor: Anthony E. Sudekum
  • Patent number: 9011533
    Abstract: Anterior cruciate ligament reconstruction methods and devices are designed to achieve an anatomically accurate double bundle anterior cruciate ligament reconstruction by using a single femoral and tibial tunnel. The method and devices reconstruct the two bundles of the anterior cruciate ligament in a single femoral and tibial tunnel using a bone-patellar tendon-bone graft. The methods and devices enable an accurate anatomical reconstruction of the anteromedial and posterolateral bundles by creating a single femoral and tibial tunnel as opposed to creating two tunnels in the tibia and femur.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: April 21, 2015
    Assignee: The General Hospital Corporation
    Inventors: Hemanth R. Gadikota, Thomas J. Gill, Guoan Li
  • Patent number: 8986378
    Abstract: The invention relates to implantable collagen devices made by seeding at least one elongate collagen construct, e.g., comprising at least one elongate synthetic collagen fiber with a plurality of cells and applying a strain and/or stress to the at least one elongate collagen fiber to induce the cells to differentiate into target phenotypes, e.g., tendon or ligament phenotype cells (and/or fibroblasts), typically with an extracellular matrix of collagen to organize into a tissue on the at least one collagen fiber.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: March 24, 2015
    Assignee: MiMedx Group, Inc.
    Inventor: Thomas J. Koob
  • Patent number: 8961604
    Abstract: A fixation implant and associated methods are presented. The fixation implant includes a shaft extending from a first end portion to a second end portion and having an intermediate portion therebetween. The intermediate portion is generally smooth and the end portions are threaded. The method includes use of the fixation implant for repair of a metapodial phalangeal joint of a human extremity. The method includes: forming a bone tunnel in a bone; approximating material near the bone tunnel; and threading the fixation implant into the bone tunnel in interference fashion to secure the material relative to the bone tunnel. The fixation implant may be cut such that the end portion is flush with the bone.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: February 24, 2015
    Assignee: Smith & Nephew, Inc.
    Inventors: T. Wade Fallin, M Mary Sinnott
  • Patent number: 8945218
    Abstract: Degradable, polymeric fiber-based, three-dimensional braided scaffolds for use as graft materials in ligament and tendon repair, reconstruction and replacement are provided. Also provided are methods for preparing these scaffolds.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: February 3, 2015
    Assignee: Drexel University
    Inventors: Cato T. Laurencin, Frank K. Ko, James A. Cooper, Helen H. Lu, Mohammed A. Attawia
  • Patent number: 8945535
    Abstract: For the repair of a cartilage defect in a human or animal patient use is made of an implant comprising an implant body including a natural cartilage matrix and being coated with cells having a chondrogenic potential. These cells are produced by in vitro cell proliferation starting from chondrocytes isolated from a cartilage biopsy. The chondrocytes which are de-differentiated during cell proliferation are re-differentiated during tissue culturing and are in particular suitable for producing and maintaining the cartilage matrix of the implant body. The cells adhering to the surface of the implant body are preferably also chondrocytes being de-differentiated by cell proliferation, but not re-differentiated, and are therefore particularly suitable for integrating the implant in the defect. Due to the cells adhering to the surface of the implant body, the implant is successfully integrated in the viable tissue surrounding the defect.
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: February 3, 2015
    Assignee: Zimmer Orthobiologics, Inc.
    Inventors: Matthias R. Steinwachs, Peter Bittmann
  • Patent number: 8900301
    Abstract: A device for surgically coupling a soft tissue graft into a tunnel of a bone. The device includes a first member and a second member. The first member includes a first graft-engaging surface extending from a first end to a second end of the first member. The second member includes a second graft-engaging surface extending from a first end to a second end of the second member. The first graft-engaging surface and the second graft-engaging surface define a graft-accepting through-passage with a longitudinal axis extending therethrough when the first member is secured to the second member.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: December 2, 2014
    Assignee: Biomet Sports Medicine, LLC
    Inventors: Kevin T. Stone, Jason D. Meridew
  • Publication number: 20140350677
    Abstract: One aspect of the present invention is a method of producing a decellularized composite tissue bioscaffold for musculoskeletal tissue interface reconstruction by physicochemically treating a musculoskeletal tissue interface isolated from allogeneic sources. In certain embodiments, such musculoskeletal tissue interfaces can also be isolated from xenogeneic sources. The method comprises treatment of the interface with detergents, chemical oxidants and ultrasonic energy, and wash steps in between to remove residual detergents as well as oxidants. The resulting bioscaffold may be freeze-dried or lyophilized, sterilized and aseptically packaged for subsequent use.
    Type: Application
    Filed: December 7, 2012
    Publication date: November 27, 2014
    Inventors: James Chang, Colin Woon, Hung Pham
  • Patent number: 8888849
    Abstract: A method of repairing soft tissue of a joint of a human extremity, such as a hand or foot. The method includes maintaining a metapodial bone intact; inserting a suture passing instrument into a space adjacent the metapodial and phalangeal bones; passing the suture through a volar ligament near a distal end of the metapodial bone and reattaching the volar ligament to the proximal phalanx. The method also includes making an incision on the dorsal aspect of the extremity to expose the dorsal aspect; inserting the distal portion of the suture passer instrument through the incision on the dorsal aspect of the extremity; inserting the distal portion of the suture passing instrument into a tendon sheath connected to a volar plate; and passing a portion of a suture through the volar plate.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: November 18, 2014
    Assignee: Smith & Nephew, Inc.
    Inventors: T Wade Fallin, M. Mary Sinnott
  • Patent number: 8882834
    Abstract: Methods and instruments for repairing soft tissues of a skeletal joint, such as, for example, of the foot or hand are presented. The method includes the steps of maintaining the metapodial bone intact; forming a bone tunnel through the proximal phalanx between volar and dorsal aspects of the proximal phalanx; passing a repair suture through the soft tissue to be repaired; passing the repair suture through the bone tunnel; and securing the suture. The method may be used for the repair of soft tissue, such as a volar ligament and/or a collateral ligament.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: November 11, 2014
    Assignee: Smith & Nephew, Inc.
    Inventors: M. Mary Sinnott, T. Wade Fallin, Kwan-Hp Chan, Patrick Michael White
  • Patent number: 8876900
    Abstract: Apparatus and methods for fixation of bone to bone, or soft tissue to bone. The apparatus comprises two fixation devices (for example, two buttons) joined by a biologic material (for example, a graft or tendon). Each fixation device is provided with at least one opening that allows the passage of the flexible material attached to the biologic material. The button may be formed, for example, of metal, PEEK or PLLA.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: November 4, 2014
    Assignee: Arthrex, Inc.
    Inventors: Gregory A. Guederian, James J. Guerra
  • Patent number: 8858633
    Abstract: The disclosure describes implantable medical products, that include dry or partially hydrated biocompatible constructs comprising collagen fibers configured to expand in situ after implantation to frictionally engage a bone tunnel wall to thereby affix the construct in the bone tunnel.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: October 14, 2014
    Assignee: Shriners Hospital for Children
    Inventors: Thomas J. Koob, Douglas Pringle
  • Patent number: 8840665
    Abstract: It is described a construct for use in surgical repair of tendon. The construct contains at least one layer of human amnion and chorion tissues and is generally cylindrical with a C-shaped cross-section to allow for ease of implantation over the tendon. Methods for preparing the construct is described. In addition, an improved method for surgical repair of a damaged or diseased tendon using the construct is also described. The improved method reduces adhesions, scar formation, inflammation and risk of post-operative infection.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: September 23, 2014
    Assignee: Liventa Bioscience, Inc.
    Inventors: Robin R. Young, Richard M. Jay
  • Publication number: 20140243979
    Abstract: A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.
    Type: Application
    Filed: May 1, 2014
    Publication date: August 28, 2014
    Applicant: The Regents of the University of Michigan
    Inventors: Ellen M. Arruda, Lisa M. Larkin, Fatima N. Syed-Picard, Michael Smietana, Jinjin Ma
  • Patent number: 8764828
    Abstract: A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.
    Type: Grant
    Filed: February 4, 2008
    Date of Patent: July 1, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: Ellen M. Arruda, Lisa M. Larkin, Fatima N. Syed-Picard, Michael Smietana, Jinjin Ma
  • Patent number: 8758438
    Abstract: An implant for orthopedic applications includes a quantity of flexible, elongated elements at least some of which possess connective tissue-healing activity, the elongated elements being arranged in substantially common alignment along their longitudinal axis.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: June 24, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Todd M Boyce, Lawrence A. Shimp
  • Patent number: 8753393
    Abstract: Biological tissues may be prepared for use in biological prostheses. The biological tissue may be fixated with glutaraldehyde and may be subjected to successive treatment of the tissue with a solution containing taurine to neutralize excess aldehyde groups that remain free after fixation.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: June 17, 2014
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Marina Strasly, Vincenzo Cassolaro
  • Patent number: 8740987
    Abstract: An implant including a substantially cohesive aggregate comprising bone-derived particles. Cohesiveness is maintained by a member of mechanical interlocking, engagement of adjacent bone-derived particles with one another through engagement with a binding agent, thermal bonding, chemical bonding, or a matrix material in which the bone-derived particles are retained. The aggregate is shaped as a one-dimensional or two-dimensional body.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: June 3, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Perry Geremakis, Jennifer Grasso, David Knaack, Jo-Wen Lin, Lawrence Shimp, Robert Waterman, John Winterbottom
  • Publication number: 20140067058
    Abstract: Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.
    Type: Application
    Filed: August 14, 2013
    Publication date: March 6, 2014
    Applicant: MIMEDX GROUP, INC.
    Inventors: Thomas J. KOOB, Robert TOFE, Elizabeth CHEN
  • Patent number: 8637066
    Abstract: A biocompatible ligament repair implant or scaffold device is provided for use in repairing a variety of ligament tissue injuries. The repair procedures may be conducted with ligament repair implants that contain a biological component that assists in healing or tissue repair. The biocompatible ligament repair implants include a biocompatible scaffold and particles of viable tissue derived from ligament tissue or tendon tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: January 28, 2014
    Assignee: DePuy Mitek, LLC
    Inventors: Francois Binnette, Julia Hwang, Mark Zimmerman, Mora Carolynne Melican
  • Patent number: 8591580
    Abstract: A method and apparatus for fixing a ligament in a bone tunnel by cross-pinning the ligament in the bone tunnel.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: November 26, 2013
    Assignee: DePuy Mitek, LLC
    Inventors: Daniel J. Mckernan, Gregory R. Whittaker
  • Patent number: 8556970
    Abstract: An instrument for placing a graft into a bone tunnel comprises an elongated shaft having a forked distal end comprising a pair of tines. A suture spans a space defined between the tines whereby the graft may be positioned between the tines and against the suture so as to be manipulated into the bone tunnel. The tendon folds about the suture, the suture having a releasable tension such that the instrument can be removed from the bone, leaving the tendon behind without the tendon hanging up on the suture.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: October 15, 2013
    Assignee: DePuy Mitek, LLC
    Inventor: Justin M. Piccirillo
  • Patent number: 8512405
    Abstract: The present invention provides a novel split barbed fixation device for tenodesis, soft tissue reattachment of tendons and ligaments to bones. The insertion device is adapted for an entirely arthroscopic approach while achieving fixation strength with ultimate pullout resistance comparable to interference screws. The device includes an integrated tendon grasper that provides for easy manipulation of the tendon arthroscopically while eliminating the need for external whip stitching of the tendon, thereby reducing preparation time. The device further includes elements that prevent the fixation implant from being destabilized or rotating during deployment and manipulation, including: a depth limiting sheath, a first implant retainer, a first implant retaining step, a tendon grasping needle tube, and an implant keyway for mating the implant to the tube.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: August 20, 2013
    Assignee: Cayenne Medical, Inc.
    Inventor: Kevin N. Baird
  • Patent number: 8470038
    Abstract: The present invention relates to a bone-tendon-bone graft and components. Embodiments of the present invention comprise an intermediate bone block that is used to adjustably secure soft tissue (e.g., tendon) in a patient. Embodiments of intermediate bone blocks of the present invention are used singly or in combination with one or more bone blocks to form a bone block assembly for securing soft tissue. The present invention further relates to an assembled bone-tendon-bone graft for implantation in humans comprising the intermediate bone block and a length of soft tissue. A bone-tendon-bone graft comprises a length of soft tissue extending from a first assembled bone block to a second bone block and then doubles back to said first assembled bone block. Depending upon the embodiment, the second bone block fixedly or slideably attaches to the length of soft tissue and facilitates it doubling back to the first assembled bone block.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: June 25, 2013
    Assignee: RTI Biologics, Inc.
    Inventors: John R. Bianchi, Zhukauskas A. Arunas, Todd E. Goede, Lauren M. Brown, Guy B. Grover, Wesley I. Lewis, Joe Kutsavage
  • Patent number: 8426199
    Abstract: A method for treating glutardialdehyde-stabilized biological tissue of animal or human origin, such as porcine, bovine pericardium or human cadaver heart valves, provides a physical plasma treatment of the, in particular, collagen tissue for increasing the biocompatibility, cell colonization and durability thereof.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: April 23, 2013
    Assignee: GfE Nanomedical International AG
    Inventors: Hanngörg Zimmermann, Markus Heinlein
  • Patent number: 8394141
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: March 12, 2013
    Assignee: RTI Biologics, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell
  • Publication number: 20130053960
    Abstract: The present disclosure provides an implantable medical device comprising a composite graft material including a first biologic component, such as an acellular tissue matrix, and a second non-biologic component.
    Type: Application
    Filed: September 14, 2012
    Publication date: February 28, 2013
    Inventors: Jason Park, Aaron Barere, Christopher T. Wagner, Robert Kiefer, E. Skott Greenhalgh
  • Publication number: 20130053961
    Abstract: A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch that has a peripheral surface and at least one fiber stitched in a reinforcing pattern to mitigate tearing of the graft, improve the fixation retention of the graft, and/or limit cyclic stretching of the graft and substantially maintain these properties following partial enzymatic degradation of the graft while it remodels. The at least one fiber includes at least one free end that extends beyond the peripheral surface of the extracellular matrix for securing the patch to a host tissue.
    Type: Application
    Filed: October 30, 2012
    Publication date: February 28, 2013
    Applicant: THE CLEVELAND CLINIC FOUNDATION
    Inventor: THE CLEVELAND CLINIC FOUNDATION
  • Patent number: 8366770
    Abstract: A biological nerve guide for implantation into a human body is made by providing a natural animal tissue membrane, crosslinking and fixing the membrane, minimizing the antigens from the membrane, tanning the membrane, coupling an active layer to an inner surface of the membrane, cutting the membrane into a desired shape and size, positioning the cut membrane onto a rod-shaped mold so that the cut membrane assumes a cylindrical configuration, and attaching a spiral support to the outer surface of the cut membrane.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: February 5, 2013
    Assignee: Grandhope Biotech Co. Ltd.
    Inventor: Guo-Feng Xu
  • Patent number: 8333802
    Abstract: The present invention provides a method of performing anterior cruciate ligament replacement. Specifically, a graft tissue is harvested from a patient and single tunnels are prepared in each of the tibia and the femur of the patient. The graft is secured in the femoral tunnel and separated into an anterior cruciate medial bundle and a anterior cruciate posterior lateral bundle. The bundles are inserted through the tibial tunnel. During insertion the posterior lateral bundle is positioned in a posterior lateral position in the tibial tunnel while the anterior cruciate medial bundle is positioned in an anterior cruciate medial position in the tibial tunnel. The anterior cruciate medial bundle is then tensioned while the patient's knee is in approximately 90 degrees of flexion, and the posterior lateral bundle is tensioned while the patient's knee is approximately in full extension. Each of the bundles is then secured in the tibial tunnel.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: December 18, 2012
    Inventor: Christopher P. Dougherty
  • Patent number: 8252056
    Abstract: Methods of repairing a joint formed by at least two bone sections are provided wherein a biocompatible osteogenic band fabricated from an osteogenic biological material such as bone, tendon, ligament and collagen is affixed to two or more bone sections.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: August 28, 2012
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Daryl R. Sybert, Lawrence A. Shimp, Todd M. Boyce, John W. Boyle
  • Patent number: 8226716
    Abstract: A method and apparatus for fixing a ligament in a bone tunnel by cross-pinning the ligament in the bone tunnel.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: July 24, 2012
    Assignee: DePuy Mitek, Inc.
    Inventors: Daniel J. Mckernan, Gregory R. Whittaker
  • Patent number: 8202318
    Abstract: A graft construct formed of a plurality of single tendon strands or soft tissue grafts placed together so that at least a portion of one of the single tendon strands is wrapped around a portion of another of the single tendon strands by employing suturing, for example. The graft construct is provided with at least two regions, one region formed of at least a plurality of tendon strands tied together, and the other region formed of loose segments of the plurality of tendon strands.
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: June 19, 2012
    Assignee: Arthrex, Inc.
    Inventor: James A. Willobee
  • Patent number: 8167943
    Abstract: Disclosed herein is an improved Bone Tendon Bone graft for use in orthopedic surgical procedures. Specifically exemplified herein is a Bone Tendon Bone graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of harvesting grafts that has improved efficiency and increases the quantity of extracted tissue and minimizes time required by surgeon for implantation.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: May 1, 2012
    Assignee: RTI Biologics, Inc.
    Inventors: Kevin C. Carter, Michael Esch, Paul LaRochelle, Jim Gross
  • Patent number: 8147546
    Abstract: A method and apparatus for surgically coupling a soft tissue replacement into a tunnel of a bone are disclosed. The method includes forming a loop of a soft tissue or soft tissue replacement. A pair of prosthetics are coupled to the loop of soft tissue to form an artificial bone-tendon-bone graft. The prosthetics and soft tissue are then placed within a tunnel formed in a bone. The relative position of the prosthetic is then fixed with respect to the tunnel.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: April 3, 2012
    Assignee: Biomet Sports Medicine, LLC
    Inventors: Kevin T Stone, Jason D Meridew
  • Patent number: 8146602
    Abstract: The invention provides a method of functionally connecting a portion of the peripheral nervous system of a vertebrate to a portion of the central or peripheral nervous system of said vertebrate, comprising the steps of bringing the portion of the peripheral nervous system and the portion of the central or peripheral nervous system close to each other, applying to the gap between the two portions a fibrin glue mixture comprising a growth factor, fibrinogen, aprotinin and divalent calcium ions so that the fibrin glue mixture is simultaneously in contact with the two portions, and forming an attachment between the portion of the peripheral nervous system and the portion of the central or peripheral nervous system of said vertebrate.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: April 3, 2012
    Assignee: Taipei Veterans General Hospital
    Inventor: Henrich Cheng
  • Patent number: 8105379
    Abstract: Disclosed herein is an improved Bone Tendon Bone graft for use in orthopedic surgical procedures. Specifically exemplified herein is a Bone Tendon Bone graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a porcine bone tendon bone graft for use in orthopedic procedures. Additionally, Also a method of harvesting grafts that has improved efficiency, increases the quantity of extracted tissue and minimizes time required by surgeon for implantation is disclosed.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: January 31, 2012
    Assignee: RTI Biologics, Inc.
    Inventors: Kevin C. Carter, Diane Carter, legal representative, Michael Esch, Paul LaRochelle, Gina Scurti
  • Patent number: 8100970
    Abstract: A biological surgical patch made by a method that includes the steps of providing a natural animal tissue that has a substrate, crosslinking and fixing the substrate, minimizing the antigens from the substrate, tanning the substrate, and incorporating an active layer in the substrate.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: January 24, 2012
    Assignee: Grandhope Biotech Co., Ltd.
    Inventor: Guo-Feng Xu
  • Patent number: 8100969
    Abstract: Various methods of ligament reconstruction are provided that can include extending a filament from at least one end of a graft having at least two ends, threading the graft through a first aperture in a first bone anchor, using the filament to affix the at least two ends of the graft to a second aperture of a second bone anchor, affixing the first bone anchor in hone, and affixing the second bone anchor in bone.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: January 24, 2012
    Assignee: DePuy Mitek, Inc.
    Inventor: Rickey D. Hart
  • Patent number: 8092529
    Abstract: Methods and devices are provided for regenerating a meniscus. The devices comprise a layer of toughened naturally occurring extracellular matrix. The devices may, optionally, further comprise a biologic material to provide a framework for meniscus regeneration. The methods comprise the steps of removing a portion of a meniscus to provide a space, and inserting a device comprising a layer of toughened naturally occurring extracellular matrix into the space.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: January 10, 2012
    Assignee: DePuy Products, Inc.
    Inventors: Prasanna Malaviya, Herbert Eugene Schwartz, Terrence David Whalen, Mark Joseph Pelo, Philip Joseph Jenks, Pamela Lynn Plouhar, Jerry Lee Lower
  • Publication number: 20110307059
    Abstract: It is described a construct for use in surgical repair of tendon. The construct contains at least one layer of human amnion and chorion tissues and is generally cylindrical with a C-shaped cross-section to allow for ease of implantation over the tendon. Methods for preparing the construct is described. In addition, an improved method for surgical repair of a damaged or diseased tendon using the construct is also described. The improved method reduces adhesions, scar formation, inflammation and risk of post-operative infection.
    Type: Application
    Filed: June 10, 2011
    Publication date: December 15, 2011
    Applicant: AFcell Medical
    Inventors: Robin R. Young, Richard M. Jay