Abstract: An expandable interbody fusion device includes superior and inferior endplates that are configured to receive a sequentially inserted stack of interlocking expansion members or wafers. The like-configured wafers include features on their top and bottom surfaces that interlock the wafers in multiple degrees of freedom so that the wafer stack is not disrupted when the fusion device is fully expanded. One of the interlocking features includes a plurality of prongs projecting from an upper surface of the wafers and into a recess defined in the lower surface of an adjacent previously inserted like-configured wafer. The prongs and recesses are configured to prevent retrograde movement of each new wafer in a direction opposite the direction of insertion. Other interlocking features prevent movement in the direction of insertion, transverse to the insertion direction and vertically within the stack.

Abstract: A visco-elastic facet joint implant for insertion into a facet joint between an inferior facet formed on a superior vertebral body and a superior facet formed on an inferior vertebral body. The facet implant includes a visco-elastic implant element molded into an anatomically fitted shape to optimally fit between the facet joint and one or more bone fixation elements to secure the visco-elastic implant element to the superior and/or inferior vertebral bodies. In use, the visco-elastic facet joint implant includes a first end for engaging the superior vertebral body, a middle portion for passing through the facet joint and an optional second end for engaging the inferior vertebral body.

Abstract: Disclosed are an apparatus for an interspinous fixation and/or distraction of vertebrae and a methodology for minimally invasive implantation of the apparatus in the spine of a patient. The apparatus corresponds to a pair of teardrop shaped lateral wing elements spaced apart by a central core element that may be selectively sized during the implantation process. The wings and central core are held together by a single threaded bolt and locking nut configuration resulting in a simple structure that may be easily implanted with minimal patient discomfort.

Abstract: An intervertebral implant, alone and in combination with an insertion tool for inserting same and a method for inserting same. The implant has upper and lower parts which have universal movement relative to each other. Each of the upper and lower parts also has a surface engaging an adjacent vertebrae. Each part has a keel extending from said surface into a cutout in the adjacent vertebrae, and each keel has an anterior opening recess therein. An insert tool has a pair of arms which are received in the recess of the keels through the anterior opening to securely hold and insert the implant. Projections and matching indentations in each arm and the base of its recess securely attached each arm within its keel.

Abstract: A spinal implant system is disclosed. The system disclosed has a first footing adapted for inter-vertebral contact with a first vertebral body, a second footing adapted for inter-vertebral contact with a second vertebral body adjacent to the first vertebral body; and, a support slideably insertable between said first footing and said second footing while said first and second footings are in-situ between said first and second vertebral bodies. The footings provide a path for the support. Distractor instruments are disclosed. Methods of use, in surgery, are also disclosed.

Abstract: The present invention relates to a material and method for providing spinal fusion. One preferred method comprises: accessing the intervertebral space defined between adjacent vertebrae; mixing magnesia, potassium biphosphate, and a calcium phosphate with an aqueous solution forming an activated spinal fusion slurry (ASFS); applying an effective amount of the ASFS to the intervertebral space between adjacent vertebrae; allowing the ASFS to set forming a bonded vertebrae structure; permitting bone growth into the bonded vertebrae structure providing fusion of the two adjacent vertebrae.

Abstract: A system and method includes a housing dimensioned to be situated between adjacent spinal bones, such as adjacent vertebrae. Screws are provided in one embodiment and are dimensioned or configured to lock against each other to retain the screws and, consequently, the cover in place. Another embodiment illustrates a plurality of plate elements that can be slidably received and locked in the cage. Each of the plate elements are adapted to receive at least one screw and guide the screw at a predetermined angle into a vertebra, thereby securing the cage in an inter-vertebral space.

Abstract: The present disclosure describes embodiments for treating a defect in a tissue, the tissue having internal and external surfaces. A device includes a first portion for positioning at one of the internal and external surfaces for applying a treatment force to the defect. In addition, the device has a second portion for applying a counter-force, where the second portion is operable to be positioned so that the counter-force is applied on the other of the internal and external surfaces, away from the defect so as to substantially avoid application of force at the defect. Furthermore, the device includes a coupling member for connecting the inner and outer portions. Methods of using the device are described, for example in an intervertebral disc having a herniation.

Abstract: Implant devices for implantation within an intervertebral space are provided, together with methods and tools for use therewith. Implant devices of the present invention include an implant body formed of a synthetic bone substitute material, such as a nanocrystalline calcium phosphate material. The implant body and the methods and tools used therewith are configured to optimize strength and stability of the implant, minimize areas of stress concentration in the implant body and promote bone growth through the implant body and fusion of the vertebra.

Abstract: An anti-retropulsion device comprising: an expandable segment; a distal collar positioned distally of the expandable segment; and a proximal collar positioned proximally of the expandable segment; wherein the expandable segment has a corresponding plurality of expandable members, and wherein each of the expandable members is configured to expand or contract radially and circumferentially in correspondence with a change in spacing between the distal collar and the proximal collar.

Abstract: Provided are keratin compositions useful in cell culture. In some embodiments the keratins are biocompatible, promote cell growth, promote cell adhesion and provide an excellent substrate for cell culture. Keratin compositions described herein may be used as coatings, gels, three-dimensional scaffolds, additives to cell culture media, microcarriers, etc. The keratin substrates may also be used to deliver cells, e.g., for cell therapy applications.

Abstract: A method for inserting an intervertebral artificial disc is provided with the intervertebral disc including a first endplate having a plurality of protrusions for attaching to an adjacent vertebrae and an extension portion extending towards a second adjacent vertebrae. A second endplate is provided with a plurality of protrusions for attaching to a second adjacent vertebrae and an extension portion extending towards the first adjacent vertebrae. A flexible member having an upper portion and a lower portion and a slider plate positioned within the upper portion of the flexible member is also provided. The extension portion of the first endplate is adapted to fit within a first cavity in the upper portion of the flexible member and the extension portion of the second endplate is adapted to fit within a second cavity in the lower portion of the flexible member.

Abstract: Implantable assemblies/devices and methods are provided for manipulating energy transferred by members defining an articulating anatomical joint, wherein the members collectively define a path of motion. Assemblies/devices are provided with a first component configured to be attached to a first anatomical member of the anatomical joint, a second component configured to be attached to a second anatomical member of the anatomical joint, and a tension member joining the first and second components. The tension member is placed under tension to absorb energy transferred by the anatomical members when the first component is attached to the first anatomical member and the second component is attached to the second anatomical member and a distance between locations of attachment of the first and second components becomes smaller then an implant-defined distance between the locations.

Abstract: The described devices are useful in the treatment of spinal disorders and pain. In particular, the described devices are designed to stabilize a portion of the spine by restoring and maintaining spacing between two adjacent vertebrae. The devices are compressible spacers that may be situated between the spinous processes of those adjacent vertebrae. The described inter spinous process spacers also allow a range of spinal motion and mimic the motion of a normally functioning spine.

Abstract: The present invention relates to devices and methods for treating one or more damaged, diseased, or traumatized portions of the spine, including intervertebral discs, to reduce or eliminate associated back pain. The present invention relates to an expandable interbody spacer.

Abstract: A system for delivering fluid to a space between two vertebrae is provided. The system includes a tool and an insert configured to be implanted in the space between two vertebrae. The tool includes a proximal end, a distal end and a structure at the distal end configured to be coupled to the insert. The tool further includes a first opening located near the proximal end of the tool, a second opening located near the distal end of the tool, and a passage extending between the first opening and the second opening. The first opening, the passage and the second opening provide a fluid delivery path from the proximal end to the exterior of the tool near the distal end. The second opening is positioned relative to the structure such that fluid is permitted to be delivered from the tool directly into the space between the two vertebrae.

Abstract: An implantable device includes a polymeric body and a metallic first mounting strip connected to a trailing end portion of the body. The body has a leading end portion, a first side surface, a second side surface, an upper surface, a lower surface and a central opening extending through the upper and lower surfaces. The central opening has an internal surface with an internal leading surface, a first internal side surface and a second internal side surface. A first depth is defined between the leading end and the internal leading surface, a first spacing is defined between the first side surface and the first internal side surface and a second spacing is defined between the second side surface and the second internal side surface. The first spacing is substantially the same as the second spacing and the first depth is less than the first spacing.

Abstract: A system for implanting an interbody device between adjacent vertebrae comprises an interbody device having a plurality of lobes extending outwardly from a longitudinal rib, and having a relaxed shape approximating the shape of the disc being replaced. An insertion guide is provided having a bore therein from a proximal end to a distal end thereof to accept the interbody device in an unrelaxed shape, wherein the distal end is shaped for insertion into an intervertebral space. The insertion rod may be positioned within the bore of the insertion guide whereby the interbody device is positioned within the intervertebral space by advancing the insertion rod into the insertion guide.

Abstract: An implant having an integrated cutting broach and/or cutting burr. The integrated implant may be inserted without requiring separate steps for drilling and broaching bone. The integrated implant assembly may include an integrated implant, a flexible sheath, a delivery rod, and a delivery pin. The implant may have a core which may have any of a variety of cross-sectional geometries. A method for fusing bone may involve inserting the implant laterally through the ilium, through the sacral-iliac joint, and into the sacrum.

Abstract: A surgical distractor comprising a base plate (2), an intermediate stage (6) telescopically coupled to the base plate (2) and a distraction plate (4) telescopically coupled to the intermediate stage (6). The intermediate stage (6) is arranged to rotate relative to at least one of the base plate (2) and the distraction plate (4) to cause telescopic movement between the intermediate plate (6) and at least one of the base plate (2) and the distraction plate (4) such that the distraction plate (4) moves towards or away from the base plate (2). Surgical instrument kits incorporating distractors and drive elements and a method of distracting two bones within a joint are also disclosed.

Abstract: Provided are devices, systems and methods related to articulating interbody cages. The device includes a caudal plate configured to be positioned adjacent a first vertebral endplate within an intervertebral disc space, a cephalad plate configured to be positioned adjacent a second vertebral endplate within the intervertebral disc space; and a first and second sidewall each rotatably coupled to both the caudal and cephalad plates. At least one of the first and second sidewalls includes a hinge element restricted from achieving an on-center or over-center rotational position around the hinge element upon dimensional expansion of the device in at least a first dimension.

Abstract: A bionic fixing apparatus is provided. The bionic fixing apparatus includes a flexible portion having at least one trench. The trench is disposed on the surface of the flexible portion and has a first end and a second end. An interval is disposed between the first end and the second end. The trench is disposed for spreading the stress applied on the bionic fixing apparatus and preventing stress concentration and stress shielding.

Abstract: The present invention relates to an apparatus and method for near-simultaneous and integrated delivery of bone graft material during the placement of surgical cages or other medical implants in a patient's spine. The integrated fusion cage and graft delivery device according to various embodiments delivers and disperses biologic material through a fusion cage to a disc space and, without withdrawal from the surgical site, may selectably detach the fusion cage for deposit to the same disc space. The integrated fusion cage and graft delivery device is formed such that a hollow tube and plunger selectively and controllably place bone graft material and a fusion cage in or adjacent to the bone graft receiving area.

Abstract: Methods and devices are provided for improving the stability, flexibility, and/or proper anatomical motion of a spinal column and more particularly, spinal implant devices are provided for use between adjacent vertebral bones. Intervertebral disc spacer devices may comprise two joined surfaces formed of compressible materials. The surfaces may be convex or any variety of shapes. Certain embodiments of intervertebral disc spacer devices include apertures through which nutrients may pass. Additionally, certain embodiments include a partial enclosure or open region between the two surfaces so as to provide an environment conducive to regrowth or stimulation of natural intervertebral disc material. In certain embodiments, the two surfaces may be attached by one or more springs. Alternatively, intervertebral disc spacer embodiments may be comprised of a coiled wire. Methods of introducing intervertebral disc spacer devices into patients are also provided.

Abstract: Various embodiments of intervertebral implants, anchoring devices for intervertebral implants, and implantation instrumentation are provided, along with various embodiments of methods for using one or more of the devices. Some embodiments of an anchoring device have a body comprising at least one curve and a rigid plate elongated along a longitudinal axis so that its front end enters at least one vertebra while its rear end remains in the passage of an implant. In some embodiments, the plate comprises at least one longitudinal slot separating at least one posterior portion of the plate into two branches, with at least one branch comprising at least one withdrawal stop configured to retain the device in the implant.

Abstract: The present invention provides an expandable fusion device capable of being installed inside an intervertebral disc space to maintain normal disc spacing and restore spinal stability, thereby facilitating an intervertebral fusion. In one embodiment, the fusion device includes a body portion, a first endplate, and a second endplate, the first and second endplates capable of being moved in a direction away from the body portion into an expanded configuration or capable of being moved towards the body portion into an unexpanded configuration. The fusion device is capable of being deployed and installed in both configurations.

Abstract: Spinal fixation plates for maintaining adjacent vertebrae in and fixed position are provided. In an exemplary embodiment, the plate includes opposed superior and inferior portions that are angled in a direction anterior to an anterior face of a mid-portion of the plate. The plate also includes a curvature formed therein about a longitudinal axis in a sagittal plane thereof. In use, when the plate is attached to adjacent vertebrae, the angle of the superior and inferior portions and the curvature in the plate are effective to position one or more thru-bores formed in the superior and inferior portions at the anterior rims of the adjacent vertebrae. In another embodiment, a spinal fixation plate is provided that is adapted to engage and mate to a fusion cage or other vertebral implant disposed between adjacent vertebra. The present invention also provides spinal fixation kits or assemblies, and methods for implanting the same.

Abstract: Implants, tools and methods for performing unilateral posterior lumbar interbody fusion are provided. An interbody implant includes a body having a top and bottom surface extending along a length thereof; and first and second side surfaces extending between the top and bottom surfaces on opposite sides of the body. The height of the first side surface is greater than the height of the second side surface.

Abstract: A spinal implant includes a wave spring configured to surround a nucleus. The spring may be formed from a shape memory material. The implant may further include an artificial nucleus configured to simulate a disc nucleus.

Abstract: The intervertebral disc prosthesis comprises first and second plates (3, 4) designed to be attached on one of the two vertebrae adjacent to the intervertebral disc to be replaced, and a compression pad arranged between the first and second plates. Each plate comprises first attaching means including two attaching portions (14a, 14b) positioned symmetrically on either side of the anteroposterior median plane of said plate, second attaching means including two attaching portions (15a, 15b) positioned symmetrically on either side of a first plane inclined by an angle comprised between 50° and 70° relative to the anteroposterior median plane of said plate, and third attaching means opposite the second attaching means relative to the anteroposterior median plane and including two attaching portions (16a, 16b) positioned symmetrically on either side of a second plane inclined by an angle of approximately 90°, relative to the anteroposterior median plane of said plate.

Abstract: A spinal fixation device includes a housing and a plurality of blades. Each blade includes a body having a central opening configured to rotate on a shaft within the housing. Control openings on opposing sides of the central opening are sized to engage prongs of a rotating tool. At least one cutting extension with a sharp leading edge extends from the body in an orientation about an axis of the shaft. Upon rotation of the blade by the rotating tool about the shaft in a direction in which the at least one cutting extension is oriented, the at least one cutting extension will break an endplate of a vertebra and hook into the vertebra.

Abstract: An intervertebral fusion cage that is adapted to contain an inserter within its inner volume during insertion of the cage.

Abstract: The present invention relates to an image-based, patient-specific medical spinal surgery technique and to a spinal prosthesis used in the surgery, and particularly, to an image-based, patient-specific medical spinal surgery technique and to a spinal prosthesis which are intended to solve a problem of damage to a spine caused by installing a spinal prosthesis used in spinal surgery, by introducing an image of a patient to manufacture an insertable spinal prosthesis that is customized for a shape of a spine of an individual patient in a polymer-based material.

Abstract: The invention encompasses devices and methods for treating one or more damaged, diseased, or traumatized intervertebral discs to reduce or eliminate associated back pain. Specifically, the invention encompasses intervertebral nucleus and annulus implants that are resistant to migration in and/or expulsion from an intervertebral disc space. The invention further encompasses kits including the implantable devices of the invention and associated delivery tools to treat annular and nuclear tissue.

Abstract: A method of inserting and positioning an intervertebral spacer is provided. The spacer includes a longitudinal axis, an on-axis interface coincident with or parallel to the longitudinal axis, and an off-axis interface angled to the longitudinal axis. The spacer's front end may be curved. The method may include inserting the spacer into the disc space utilizing a tool to engage an on-axis interface and then to engage one or more of the off-axis interfaces, which may be used for further modification of the spacer. The tool is moved substantially along a single insertion direction, which may be substantially parallel to a posterior-anterior axis of the disc space. The method may result in the longitudinal axis of the spacer being perpendicular to the insertion direction, or substantially parallel to a medial-lateral axis of the disc space. The spacer may also be positioned in an anterior aspect of the disc space.

Abstract: Deflectable implants, systems and methods for implanting deflectable implants are disclosed. The deflectable implant includes at least one sequence of segments, the sequence includes at least two segments, the segments being interconnected at effective hinges, the sequence assuming a straightened or low curvature insertion state for insertion into the body, the sequence being deflectable to a fully deflected state defined by abutment of abutment features of adjacent of the segments.

Abstract: The invention relates to a vertebral implant (1) intended to be implanted in a patients intersomatic space and comprising an intersomatic cage (2) and at least one fixing screw (10) intended to be screwed into the bony mass through a well (7) of said cage (2) to stabilize the position of said cage (2) within the intersomatic space, said implant (1) being characterized in that the well (7) and the screw (10) form a system for the self-locking of the screw (10) in the well (7), said system comprising a male means secured to the screw (10) and a female means formed by the walls (72) of the well (7), the male means being locked in position by the female means.

Abstract: A middle-expanded, removable intervertebral disk cage and stabilizer for stabilizing adjacent vertebrae and a method for intervertebral disk stabilization in which adjacent vertebrae are spread and a portion of the intervertebral disk is removed from between the adjacent vertebrae.

Abstract: The present invention teaches an improved spinal fusion implant and method of implanting same. The implant includes a shell and an insert, the insert capable of situating first and second plates of the shell with respect to each other and of preventing unwanted loosening of fasteners placed through the shell and into the adjacent vertebral bodies. The method includes implanting a shell, selecting an insert from a plurality of inserts, and placing an insert between first and second plates of the shell.

Abstract: An intervertebral fixation device is disclosed, which includes a weight-bearing shell, a first anchor, a second anchor, and a key. The shell includes a first and second opposing sidewalls at a distance from one another, a keyway that extends along at least a portion of the distance, and a first axis of rotation and a different second axis of rotation that extend along at least a portion of the distance and are outside the keyway. The first anchor is rotatably coupled to the weight-bearing shell about the first axis of rotation, and the second anchor is rotatably coupled to the weight-bearing shell about the second axis of rotation. The key is insertable into the keyway such that the first anchor and the second anchor are securable in divergent orientations with respect to the weight-bearing shell.

Abstract: The present invention generally relates to a method of using a matrix as a barrier for unwanted cell attachment and bone formation in unwanted areas of the human body during implant procedures. More specifically, a growth-inhibiting matrix may be used to prevent migration of osteo-inductive agents or bone tissue from an intervertebral disc space through the outer bands of annulus fibrosis that abuts the spinal tissue, canal, and other surrounding areas.

Abstract: An implant for therapeutically separating bones of a joint has two endplates each having an opening through the endplate, and at least one ramped surface on a side opposite a bone engaging side. A frame is slideably connected to the endplates to enable the endplates to move relative to each other at an angle with respect to the longitudinal axis of the implant, in sliding connection with the frame. An actuator screw is rotatably connected to the frame. A carriage forms an open area aligned with the openings in the endplates. The openings in the endplates pass through the carriage to form an unimpeded passage from bone to bone of the joint. The carriage has ramps which mate with the ramped surfaces of the endplates, wherein when the carriage is moved by rotation of the actuator screw, the endplates move closer or farther apart.

Abstract: A bone infusion apparatus for interbody grafts includes a container; a retainer, the retainer including a recess for receiving therein bone graft material; and a lid including a plunger assembly. A method of preparing bone including cadaver bone for use in cervical fusion includes: placing cadaver bone combined with bone collected from a patient into a recess of the retainer; placing the retainer in the container; filling the container with a liquid; attaching a lid the container; depressing a plunger of the lid such that a press head advances toward the retainer causing a dynamic pressure to act on the cadaver bone combined with the bone collected from the patient; suctioning the liquid from the container; removing the combined bone from the retainer; and placing the combined bone removed from the container into a vertebral interspace of the patient.

Abstract: A vertebral body replacement device includes a body member and a central rod member having two threaded portions and configured to be operatively associated with the body member. The device also includes a first end member and a second end member with the end members configured to threadingly engage the threaded portions of the central rod member. The body member and the two end members are further constructed to inhibit rotational movement of the two end members when the device is positioned within a space within a spine as the two end members will engage the adjacent respective vertebral bodies following rotational actuation of the central rod member causing the end members to move in an axial direction relative to the body member, thereby allowing the two end members to apply a force to the two vertebral bodies. A surgical instrument and method for using the device are also disclosed.

Abstract: An intervertebral implant and associated insertion instrument. The intervertebral implant includes an instrument engagement interface including first and second channels extending along opposite sides of the implant forwardly from a trailing end wall of the implant and a positioning projection extending rearward from the trailing end wall of the implant. The insertion instrument includes a grasping mechanism for engagement with the instrument engagement interface. The grasping mechanism includes first and second jaws including grasping portions positionable in the first and second channels and an enlarged opening defined between the first and second jaws for receiving the positioning projection therein.

Abstract: A spinal implant which is configured to be deployed between adjacent vertebral bodies. The implant has at least one fixation element with a retracted configuration to facilitate deployment of the implant and an extended configuration so as to engage a surface of an adjacent vertebral body and secure the implant between two vertebral bodies. Preferably, the implant is expandable and has a minimal dimension in its unexpanded state that is smaller than the dimensions of the neuroforamen through which it must pass to be deployed within the intervertebral space. Once within the space between vertebral bodies, the implant can be expanded so as to engage the endplates of the adjacent vertebrae to effectively distract the anterior disc space, stabilize the motion segments and eliminate pathologic spine motion. Angular deformities can be corrected, and natural curvatures restored and maintained.

Abstract: A surgical implant device, comprising: a body portion defining a plurality of ports; a plurality of bone screws disposed partially through the plurality of ports defined by the body portion; a locking plate disposed over a head portion of at least one of the plurality of bone screws and engaging a plurality of recesses manufactured into a side of the body portion; and a screw operable for compressing the locking plate against the side of the body portion. Optionally, the surgical implant device further comprising: one or more surfaces comprising a plurality of protruding structures; wherein the body portion and the one or more surfaces comprising the plurality of protruding structures are integrally formed. The one or more surfaces comprising the plurality of protruding structures are formed by an additive manufacturing process. Optionally, the surgical implant device comprises one of an anterior lumbar interbody fusion cage and a cervical cage.

Abstract: An intervertebral implant includes an insertion end, an opposing engagement end, and first and second opposed main surfaces configured to contact respective adjacent vertebral endplates. Each of the first and second main surfaces has an anterior edge, a posterior edge, and extends between the insertion and engagement ends. Anterior and posterior walls are formed between the first and second main surfaces and along the respective anterior and posterior edges and converge at the insertion and engagement ends. A slot is formed at the engagement end and extends continuously between and at least partially along the anterior and posterior walls. A post is positioned within the slot, spaced from at least one of the anterior and posterior walls and extending at least partially between the first and second main surfaces. The post includes a plurality of exposed facets and is configured for engagement with a pivotable insertion instrument.

Abstract: The present invention relates to a cage which is inserted between vertebral bodies of a cervical vertebra or spine during an operation for treating a cervical disc disease, myelosis, or fracture of the cervical vertebra or spine, and more particularly, to a cage with spikes, including upper and lower spikes which are attached to a clip inserted into a main body of the cage, unfolded upward and downward from the main body, and locked to vertebral bodies of a cervical vertebra or spine positioned at the top and bottom of the cage such that the cage is fixed and locked between the vertebral bodies.

Abstract: An interbody spinal fusion implant made of a material other than bone adapted for placement across an intervertebral space formed across the height of a disc space between two adjacent vertebral bodies. The implant has a trailing end with a bone screw receiving hole for receiving at least one bone screw to engage the vertebral bodies.