Abstract: The implant includes two side walls resting against the vertebral end-plates and an intermediate wall joining the supporting walls. The implant can be deformed for insertion between the vertebrae to be treated to restore the attenuated mobility of the vertebrae, and includes mounting elements mounting on the vertebrae. The side walls have a curved shape, whose convexity is oriented towards the outside of the implant; the intermediate wall has a curved shape, whose convexity is oriented towards the outside of the implant such that it does not form any pronounced angles with the supporting side walls. The supporting side walls and the intermediate wall, have a partially oval shape; and the mounting elements are configured such that the implant can be mounted on the vertebrae.

Abstract: A surgical hook insertion device includes an elongate body defining a lumen therethrough and an actuation assembly. The elongate body has a retaining portion configured and dimensioned to releasably retain a laminar hook therein. The actuation assembly includes an actuation rod and an actuator member. The actuation rod is slideably disposed within the lumen of the elongate body. The actuator member is operatively coupled with the actuation rod and is slideably mounted on the elongate body, wherein the actuation assembly is transitionable between a first position in which a portion of the actuation rod engages the laminar hook releasably disposed in the retaining portion and a second position in which the actuation rod disengages the laminar hook.

Abstract: Provided is a growth factor anchoring type bone graft material, wherein a bone graft substrate exposing at least a collagen fiber is bound to a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide. The same can be produced by mixing a bone graft substrate and a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide, and is also superior in osteogenic ability.

Abstract: The present invention provides spinous process implant and associated methods. In one aspect of the invention the implant limits the maximum spacing between the spinous processes. In another aspect of the invention, a spacer has at least one transverse opening to facilitate tissue in-growth. In another aspect of the invention, an implant includes a spacer and separate extensions engageable with the spacer. In another aspect of the invention, instrumentation for inserting the implant is provided. In other aspects of the invention, methods for treating spine disease are provided.

Abstract: A dynamic subsidence plate is described having a first plate member and a second plate member in sliding engagement that may infinitely subside between a first and second assembled position. The plate includes a lock assembly associated with the first and second plate members. The lock assembly includes a ramp portion, an interference portion, and a bearing member situated between the ramp portion and the interference portion. The lock assembly of the plate is configured to allow movement of the first member with respect to the second member in a first direction in an infinite number of positions between a first assembled position and a second assembled position. Further, the lock assembly alternatively prevents movement of the first member with respect to the second member in an opposite second direction between the first and second assembled positions.

Abstract: An implant for performing interbody fusion within a human spine, inserters for such an implant, and associated methodology. The implant is preferably formed in situ from at least two separate but lockable members (a base member and a closure member). The base member may be implanted into an interbody space first, after which the end plates may be finally prepared and the base member packed with fusion promoting substances before engaging and locking the closure member. The closure member provides structural support for the adjacent vertebral bodies (along with the base member) and may be selected after implantation of the base member having a specific length, width, height, taper, etc. . . . to ensure an optimal sizing of the implant for desired restoration of disc height, coronal taper, sagittal taper, etc. . . . .

Abstract: A spinal fusion implant of non-bone construction to be introduced into any variety of spinal target sites. The spinal fusion implant of the present invention includes a top surface, a bottom surface, first and second lateral sides, a proximal (posterior) end and a distal (anterior) end. The spinal fusion implant of the present invention may be used to provide temporary or permanent fixation within an orthopedic target site. To do so, the spinal fusion implant may be introduced into a disc space while locked to a surgical insertion instrument and thereafter employed in the proper orientation and released. Once deposited in the disc space, the spinal fusion implant of the present invention effects spinal fusion over time as the natural healing process integrates and binds the implant.

Abstract: Spinal implants for positioning between adjacent vertebrae. Some embodiments may comprise a pair of opposed sidewall surfaces, a pair of opposed frictional surfaces, a first end wall joining the pair of opposed sidewall surfaces, and a second end wall recessed at least in part and joining the pair of opposed sidewall surfaces. A fish-tailed structure may be positioned within the second end wall when viewed from one of the opposed frictional surface. The fish-tailed structure may be formed so as to extend at least substantially uninterrupted between at least one of the opposed sidewall surfaces and the opposed frictional surfaces. A retention structure, such as a hole, may be positioned within the fish-tailed structure. The hole may be configured to engage a surgical implantation device.

Abstract: An interbody implant system is provided. The interbody implant system includes an implant having an engagement surface and an instrument including a first member and a second member that is movable relative to the first member. The first member is configured to capture the implant and the second member includes an interface configured to engage the engagement surface to releasably lock the implant in at least one orientation relative to the second member. The at least one of the engagement surface and the interface include at least one planar face. Methods of use are disclosed.

Abstract: Methods and devices are disclosed for treating the vertebral column. An implant for treating the spine is provided comprising at least two articulations between the spacer and the bone facing surface of the fixation plate. Another implant for treating the spine is also provided, comprising two or more fixation plates attached to a spacer with two or more articulations, wherein the fixation plates are independently movable.

Abstract: An implant for use in high tibial osteotomy can include a central implant portion, a first side implant portion and a second side implant portion. The first and second side implant portions can be selectively rotatable relative to each other. A method of performing high tibial osteotomy can include providing an implant having a superior surface and an inferior surface. The first superior surface and the second inferior surface can define an implant angle therebetween. A correction angle of the tibia can be determined. A first cut can be made in the tibia. An angle of a second cut relative to the first cut can be determined based on a difference between the implant angle and the correction angle. The second cut can be made in the tibia. The tibia can be opened creating an opening for receipt of the implant. The implant can be inserted into the opening.

Abstract: An intervertebral implant for mutual situating of adjacent vertebrae includes a cover and a driving mechanism mounted in the cover. The cover presents a manipulative hole and a seat. The driving mechanism is located in the seat and includes a rotational element with anchoring to engage a vertebra. The implant includes a connecting element located within the diameter of the manipulative hole and operable to be engaged by a driving tool.

Abstract: A system and methods for promoting fusion across an intervertebral disc space, the system including an expandable system of spinal fusion implants wherein the system of implants is inserted into an intervertebral disc space in a smaller profile, collapsed insertion state, and then expanded anteriorly to an expanded state.

Abstract: Systems and methods are described for correcting sagittal imbalance in a spine including instruments for performing the controlled release of the anterior longitudinal ligament through a lateral access corridor and hyper-lordotic lateral implants.

Abstract: An implant configured to be placed in a living body to be expansively deformed and contractively deformed comprises a first layer that forms a filling unit that is configured to be filled with a filling material to maintain an expanded state of the implant, the first layer comprising a porous membrane; a second layer that covers the first layer, the second layer comprising at least one of (i) a fluid-impermeable membrane, and (ii) a gas-permeable porous membrane that is impermeable by liquids or gels; and an introduction port that communicates with the filling unit and is configured to introduce the filling material into the filling unit. An introduction region is formed between the first layer and the second layer, the introduction region being configured to receive a fluid permeating the first layer when the filling material is introduced into the filling unit.

Abstract: Various exemplary embodiments relate to a spinal implant for insertion between two adjacent vertebrae, the spinal implant including one or more of the following: a cage comprising: a frame sized to be inserted between the vertebrae, the frame comprising a fastener hole and a cage alignment structure, the cage alignment structure comprising at least one of: a cage groove and a cage ridge; a bone plate comprising a bone plate alignment structure a through hole, wherein the bone plate alignment structure comprises at least one of a bone plate groove and a bone plate ridge, and wherein the bone plate alignment structure and the cage alignment structure are configured to interact with each other to provide an indication when the bone plate is properly aligned with the cage; and a fastener to attach the bone plate to the cage when inserted through the through hole and into the fastener hole.

Abstract: The present invention relates to an expandable prosthetic implant device for engagement between vertebrae generally comprising an inner member, outer member, gear member and a locking assembly positioned coaxial with respect to each other such that the inner and outer members are moveable relative to each other along an axis. The gear member is axially fixed to the outer member and freely rotatable with respect to the outer member and the gear member threadedly engages a threaded portion of the inner member to translate inner member along the axis. The implant is configured to engage the vertebrae in a predetermined alignment and the gear member includes gear teeth exposed to the exterior and configured to be accessible by a tool member at a plurality of angular positions around the perimeter of the implant device.

Abstract: Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned.

Abstract: An improved bone screw for humans or mammals is a bone screw having exposed surfaces along a shank and threads extending from the shank with one or more selected portions of the exposed surfaces having a 3-dimensional pattern. The pattern provides enhanced resistance to thread loosening when affixed to bone. The exposed surface is on exterior portions of the threads or portions of the shank or both. The one or more selected portions of the exposed portions having a bone formation enhancing 3-dimensional patterns are in the external exposed thread surfaces or in the exposed shank surfaces or both.

Abstract: A system for flexibly stabilizing a vertebral motion segment of the facet joint by connecting a first vertebra and a second vertebra is disclosed. The system includes an elongate connection element with end portions interconnected by a flexible coupling member. The system includes first and second attachment portions for connecting the connection element to the vertebrae. A first resilient member is positioned between the first end portion and the first attachment portion, and a second resilient member is positioned between the first attachment portion and the second attachment portion.

Abstract: The present invention relates to an expandable prosthetic implant device for engagement between vertebrae generally comprising an inner member, outer member, gear member and a locking assembly positioned coaxial with respect to each other such that the inner and outer members are moveable relative to each other along an axis. The gear member is axially fixed to the outer member and freely rotatable with respect to the outer member and the gear member threadedly engages a threaded portion of the inner member to translate inner member along the axis. The implant is configured to engage the vertebrae in a predetermined alignment and the gear member includes gear teeth exposed to the exterior and configured to be accessible by a tool member at a plurality of angular positions around the perimeter of the implant device.

Abstract: Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.

Abstract: A cartilage replacement or repair prosthesis comprises a layer of streamlined elastomer elements, preferably in the form of spheres, supported in a matrix material so that the radially opposed surfaces of the spheres are positioned on opposite surfaces of the layer and make contact with the opposed surfaces of the femur and tibia and the forces exerted between these bones extend through the streamlined elements. The matrix material has a substantially lower resistance to deformation than the spheres to control the position of the spheres relative to one another without significantly restraining their load-responsive deformation under forces exerted between the femur and tibia. The layer, with its elastomeric inserts, is sufficiently thin and flexible to allow it to be rolled for arthroscopic insertion into a knee joint.

Abstract: An interbody spinal fusion assembly includes an interbody cage, planar metal pins and bone fasteners. The interbody cage includes a metal cage and a PEEK insert. The PEEK insert is inserted into a slot of the metal cage and is secured to the metal cage with a pin. The assembled interbody cage is inserted in the space between two adjacent vertebras and is secured in placed with the planar metal pins and the bone fasteners.

Abstract: Disclosed are bioscaffolds and methods for use in soft tissue repair.

Abstract: System, including apparatus, methods, and kits, for replacement of the proximal end of a radial bone with a prosthesis having a floating articular member. The prosthesis may include a head portion connected or connectable to a stem portion. While the stem portion remains operatively connected to the head portion, the head portion and/or an articular member thereof may be permitted to float in position relative to the stem portion. The head portion/articular member may float transversely (e.g., translationally) and/or rotationally with respect to the stem portion. The articular member may articulate with a humeral bone or both a humeral bone and an ulnar bone. In some embodiments, the head portion may include a fixed member for articulation with an ulnar bone and a floating member for articulation with a humeral bone.

Abstract: An intervertebral spacer implant can include: a plurality of links, each link having a hole bored along an axis of said link and said hole of each link of said plurality of links aligns to form a channel bored through said plurality of links, wherein a first link of said plurality of links is pivotally engaged to a second link of said plurality of links. The implant can include an elongated member, such as a guide wire, adapted to retain said plurality of links, wherein said elongated member is configured to mate with each said hole of each link of said plurality of links. At least one link of the plurality of links includes a body having one or more textured sides. The elongated member is adapted to allow said plurality of links to rotatably articulate with respect to one another, such as by a hinge.

Abstract: The present application generally relates to orthopedic systems, and in particular, to systems including independent plates and spacers. A plating system can include a spacer and a plate that is independent from the spacer. A number of locking mechanisms can be provided to secure the plate to the spacer. In some cases, the spacer includes a pair of notches that extend on an outer surface of the spacer. The plate can include a pair of lateral extensions that can engage the notches to secure the plate to the spacer. In other cases, the spacer includes an opening including a pair of inlets. The plate can include an enclosed posterior extension that can be received in the pair of inlets to secure the plate to the spacer.

Abstract: Compositions and methods are provided for stabilization and treatment of vertebrae, and in particular for stabilization and treatment of a vertebra having a fracture. Compositions are provided that stabilize and heal a fracture while facilitating healing and reducing the chance for re-injury to the vertebra or adjacent vertebra. Methods include elevation of the vertebra to facilitate healing under reduced pressure situations and include leverage points to elevate the fracture before or during composition insertion.

Abstract: The present application is directed to vertebral rods and methods of use. In one embodiment, the rod includes upper and lower sections that are separated by an intermediate section. The intermediate section may include one or more members, and may have a variety of configurations. An elastic member may be positioned within the intermediate section. The intermediate section and the elastic member may provide for variable resistance during movement of the upper and lower sections. In one embodiment, the resistance increases the further away the upper and lower sections move from a first orientation.

Abstract: A spinal interbody device includes a compliant inner dampener in combination with outer shells. An inner dampener includes a rim with pillars and heads coupled to a complementary structure of the outer shells.

Abstract: A four-component artificial intervertebral disc may provide six degrees of movement: flexion, extension, lateral bending, axial rotation, axial deflection, and anterior/posterior translation. The disc may include a superior endplate, a superior core, an inferior core, and an inferior endplate. The superior endplate may include a concave mating surface, and the inferior endplate may include a spherical mating surface. The superior endplate may roll across the superior core to provide flexion, extension, and lateral bending. The superior endplate may twist or rotate atop the superior core to provide axial rotation, and the superior endplate may slide over the superior core to provide anterior/posterior translation. The superior core may be connected to the inferior core, and the inferior core may be connected to the inferior endplate. The inferior core may be made from a flexible material that may enable the artificial disc to expand or compress vertically.

Abstract: A prosthetic implant for restoring lamina after a laminectomy. The implant is generally a lamina-sized construct having a hollow interior. The lamina removed during the laminectomy may be converted to autologous bone that may then be placed inside the hollow interior of the implant. The implant may then be secured to the spine at the site of the laminectomy so that lamina restoration can occur as the hollow interior of the implant solidifies with bone growth.

Abstract: An intervertebral implant for the fusion between two vertebral bodies of a vertebral column may include a body having two opposite surfaces and holes or cavities for filling purposes during bone growth, and an engagement portion for receiving a gripping end of a positioning instrument. The engagement portion may be shaped as a splined shaft accessible through an opening of the body.

Abstract: A spinal implant includes a first member having a wall that defines an axial cavity. A second member extends between a first end and a second end and defines a longitudinal axis. The second member is configured for disposal with the axial cavity and translation relative to the first member. A third member has an outer surface engageable with tissue and an inner surface disposed to dynamically engage the first end in response to the engagement of the outer surface with the tissue. Systems and methods are disclosed.

Abstract: A spinal interbody device includes a base link having a first end and a second end, and a linkage including a first link having a first end and a second end and a second link having a first end and a second end. The first end of the first link is coupled to the first end of the base link at a first hinge, the second end of the first link is coupled to the first end of the second link at a second hinge; and the second end of the second link is coupled to the second end of the base link at a third hinge.

Abstract: An artificial disc prosthesis is provided. The prosthesis of the present invention enables spinal segment alignment by having a variable height across its surface. The variable height is achieved by an asymmetric artificial nucleus or by at least one variable height end plate.

Abstract: The present invention relates generally to a prosthetic spinal disc for replacing a damaged disc between two vertebrae of a spine and methods for inserting said discs. The present invention also relates to prosthetic spinal disc designs that are implanted using a transforaminal approach, methods thereof, and apparatus thereof.

Abstract: A method and apparatus for replacing damaged meniscal tissue includes a meniscus implant including a porous body having a plurality of interconnected open micro-pores and one or more open cavities for receiving meniscal tissue. The interconnected micro-pores are arranged to allow fluid to flow into the porous body and are in fluid communication with the one or more open cavities.

Abstract: The present invention provides an expandable fusion device capable of being installed inside an intervertebral disc space to maintain normal disc spacing and restore spinal stability, thereby facilitating an intervertebral fusion. In one embodiment, the fusion device includes a body portion, a first endplate, and a second endplate, the first and second endplates capable of being moved in a direction away from the body portion into an expanded configuration or capable of being moved towards the body portion into an unexpanded configuration. The fusion device is capable of being deployed and installed in both configurations.

Abstract: Vertebral body replacement apparatuses, systems, and methods are provided. In various examples, an implantable device is configured to be inserted between a first vertebral body and a second vertebral body. The implantable device includes a first endplate configured to contact a superior endplate of the first vertebral body. A central member is pivotably coupled to the first endplate. A second endplate is configured to contact an inferior endplate of the second vertebral body. The implantable device includes a first insertion configuration and a second load-bearing configuration. The first insertion configuration includes the central member at a first angular position with respect to the first endplate. The second load-bearing configuration includes the central member at a second angular position with respect to the first endplate and the second endplate in a load-bearing position.

Abstract: Intervertebral spacers, such as interbody vertebral cages, that facilitate minimally-invasive corrective restoration surgeries, and related methods. In some implementations, an introducer may be used introduce an intervertebral spacer in a first, straightened shape into an intervertebral disc space. The introducer may engage a plurality of adjacent recesses of the intervertebral spacer to maintain the intervertebral spacer in the first, straightened shape during introduction. An introducer, in some cases the same introducer, may be used to articulate the intervertebral spacer by actuating at least one hinge of the intervertebral spacer such that the intervertebral spacer assumes a second, curved shape once within the intervertebral disc space.

Abstract: MIS TLIF systems and related methods. Implementations of distractor devices may include a first portion and a second portion where the second portion is slidably coupled over the first portion. A position of the second portion relative to the first portion may be adjustable through contacting a distractor latch coupled to the second portion with a plurality of teeth on a side of the first portion. The first portion may include a first pedicle screw pin on an end of the first portion opposing the second portion. The second portion may include a second pedicle screw pin on an end of the second portion opposing the first portion. The first pedicle screw pin and the second pedicle screw pin may be both configured to couple with a pedicle screw head. A length of the distractor device may be configured to be adjustable through sliding of the first portion.

Abstract: A spinal interbody device includes a compliant inner dampener in combination with a rigid outer material of outer shells. An inner dampener includes a rim with pillars and heads coupled to a complimentary inner structure of the outer shells.

Abstract: An intervertebral implant consisting of multiple elements connected by a flexible member and a method of positioning said implant via an operative corridor having an axis oblique to the disc plane. The implant is advanced through the operative corridor by altering the orientation of the first element of the implant such that it is in general alignment with the disc space plane without altering the alignment of the second element of the implant. Upon insertion of the first element into the disc space, the orientation of the second element is altered to be in general alignment with the disc space and the second element is inserted into the disc space.

Abstract: Described here are deformable monolithic, stabilization devices, or implants, suitable for use within bone and between bones, for instance, to fuse vertebral bodies, to repair herniated discs, or to repair spinal compression fractures. The implants are introduced into a chosen site at a first, smaller height and then plastically deformed to achieve a second, but unique, pre-selected, larger height. Variations of the device provide one or more specific larger heights. The devices are particularly suitable as intervertebral spinal fusion implants for the immobilization of adjacent vertebral bodies. Methods of deploying the implants are also described as are instruments for such deployment.

Abstract: Various spinal implants and methods for stabilizing the spine are provided. In one exemplary embodiment, a spinal implant is provided having an expandable container with an interior volume that is selectively expandable between a compressed condition and an expanded condition. The expandable container is coupled to a superior endplate member having a bone-contacting surface and an engagement surface effective to mate with a superior surface of the expandable container, and an inferior endplate member having a bone-contacting surface and an engagement surface effective to mate with an inferior surface of the expandable container. In addition, at least one inlet port is formed in the expandable container and is effective to communicate a fluid to at least one cavity disposed within the interior volume of the expandable container.

Abstract: An allograft interspinous spacer for implantation into an interspinous space located between spinous process of adjacent vertebrae. The spacer preferably includes a body, a core and a plurality of deployable retainers. The body may be operatively associated with the plurality of deployable retainers. In use, after the body has been inserted into the interspinous space, the plurality of retainers is deployed so that they prevent migration of the spacer. The core is preferably sized and configured to be inserted and/or moved into operatively engagement with the body to deploy the plurality of retainers.

Abstract: An expandable interbody fusion device includes superior and inferior endplates that are configured to receive a sequentially inserted stack of interlocking expansion members or wafers. The like-configured wafers include features on their top and bottom surfaces that interlock the wafers in multiple degrees of freedom so that the wafer stack is not disrupted when the fusion device is fully expanded. One of the interlocking features includes a plurality of prongs projecting from an upper surface of the wafers and into a recess defined in the lower surface of an adjacent previously inserted like-configured wafer. The prongs and recesses are configured to prevent retrograde movement of each new wafer in a direction opposite the direction of insertion. Other interlocking features prevent movement in the direction of insertion, transverse to the insertion direction and vertically within the stack.

Abstract: A visco-elastic facet joint implant for insertion into a facet joint between an inferior facet formed on a superior vertebral body and a superior facet formed on an inferior vertebral body. The facet implant includes a visco-elastic implant element molded into an anatomically fitted shape to optimally fit between the facet joint and one or more bone fixation elements to secure the visco-elastic implant element to the superior and/or inferior vertebral bodies. In use, the visco-elastic facet joint implant includes a first end for engaging the superior vertebral body, a middle portion for passing through the facet joint and an optional second end for engaging the inferior vertebral body.