Abstract: A device implantable in a human body comprising a first component, or main support component, delimiting a plurality of openings, and a second component disposed on a surface of the main support component.

Abstract: A placeholder for vertebrae or vertebral discs includes a tubular body, which along its jacket surface has a plurality of breakthroughs or openings for over-growth with adjacent tissue. The placeholder includes at least a second tubular body provided with a plurality of breakthroughs and openings at least partially inside the first tubular body. The first and second tubular bodies can have different cross-sectional shapes, can be are arranged inside one another by press fit or force fit or can be connected to each other via connecting pins and arranged side by side to one another in the first body.

Abstract: Described herein is an antiviral face mask and methods of use thereof to inactivate a virus in contact with the face mask. The face mask may include a fibrous material with silicon nitride powder impregnated therein and a layer surrounding the fibrous material. In some embodiments, silicon nitride is present in the fibrous material at a concentration of about 1 wt. % to about 15 wt. %.

Abstract: Described herein are antiviral compositions and apparatuses and methods of use thereof to inactivate a virus in contact with the composition or apparatus. The composition and/or apparatus include silicon nitride at a concentration of 1 wt. % to 15 wt. % and the silicon nitride inactivates at least 85% of the virus in contact with the composition and/or apparatus.

Abstract: Various embodiments related to systems, methods, and articles for rapid inactivation of SARS-CoV-2 by silicon nitride and aluminum nitride are disclosed herein.

Abstract: A surgical port includes an end face with a channel extending through the end face. The channel has a cross section shaped to receive a surgical instrument cannula. A lateral wall extends around a perimeter of the end face. The lateral wall and end face enclose an open volume. A rim extends radially inward from the lateral wall and projects into the open volume. An apron portion extends radially outward from the lateral wall and in a direction axially away from the end face. Surgical systems may include surgical ports. Methods relate to using surgical ports.

Abstract: An implant is provided for use in an ankle joint between reconditioned end surfaces established on a distal end of an upper tibia bone and an opposing lower talus bone. The implant comprises a substantially porous rigid component adapted to be anchored against the upper tibia reconditioned end surface and the lower talus reconditioned end surface. The component defining an opening therethrough. An intramedullary nail is configured to pass through the opening in the component when the nail is driven through the talus and into the tibia.

Abstract: An innovative dome toe resurfacing system for performing metatarsophalangeal joint replacement is disclosed. The present invention comprises a prosthetic implant for metatarsophalangeal joint, and one or more cone extensions that covers portions of the prosthesis that extends into the metatarsal bone and phalanx bone. The cone extensions include a plurality of ridges that will catch bone on insertion and provide a press fit. The present invention also includes a cone and cup reaming system wherein one or more reamers will ream a cone/cup shape for the articular surfaces, and prepare the metatarsal and phalangeal canals for the insertion of the cone extensions. The cone extensions have ends that fit the reamed cone/cup shape wherein the cone/cup shape resembles the natural anatomy of articular surfaces of metatarsophalangeal joint.

Abstract: An implantable device may be provided. The implantable device may comprise an upper assembly comprising a ramped base and a pair of opposing windows. The pair of opposing windows may extend upward from either lateral side of the ramped base. A gripping assembly may be disposed in each window. The implantable device may further comprise a lower assembly comprising a ramped base and a pair of opposing windows. The pair of opposing windows may extend down from either lateral side of the ramped base. A gripping assembly is disposed in each window. The implantable device may further comprise a ramped actuator assembly disposed between the upper assembly and the lower assembly. The ramped actuator may be configured to transition the implantable device from a collapsed form having a first height to an expanded form having a second height and wherein the second height is greater than the first height.

Abstract: Therapeutics and methods of treatment to repair, preserve and grow cartilage are presented. In addition, systems and methods for delivering a therapeutic to a hard to reach anatomical area, such as, for example, the BCI, are presented. A cannulated delivery device provided with a cutting tip, cutting flutes and threads on its distal end can be provided. Using such an exemplary device, various novel therapies for joint and cartilage repair, preservation and generation can be implemented. The device may have two-needles, with a first cannula/needle, with a finger grip at its distal end, and a longer inner needle to penetrate through the outer needle into the disc, and introduce therapeutics, for example, via a syringe. When provided with a septum at the inner needle's proximal end, the PIARES device is a completely closed system, and its use minimizes trauma.

Abstract: The present application relates to an endoprosthesis including a first member which is connected to a patient's bone; a second member which is adjustably coupled to the first member by a coupling device; wherein the coupling device is configured to generate a movement of the second member relative to the first member. The present application also relates to an artificial joint including such an endoprosthesis and to an endoprosthesis placement system including such an endoprosthesis or artificial joint and a projection device which is configured to project visible light markings, acquired from pre-operational and/or intra-operational patient data, onto the patient and/or the endoprosthesis, thus enabling visible alignment markings of the endoprosthesis to be aligned with respect to projected visible light markings so as to allow a proper adjustment of the endoprosthesis.

Abstract: A bone graft implant and methods of using the same are provided herein.

Abstract: A threaded medical implant comprising a biocomposite, said biocomposite comprising a polymer and a plurality of reinforcement fibers, wherein a weight percentage of a mineral composition within the biocomposite medical implant is in the range of 30-60%, wherein an average diameter of said fibers is in a range of 1-100 microns, said medical implant being threaded with a plurality of threads; wherein said fibers comprise a plurality of helical fibers and a plurality of longitudinal fibers; wherein a weight to weight percent ratio of said helical to said longitudinal fibers is from 90:10 to 10:90.

Abstract: Patient-specific craniofacial implants structured for filling bone voids or planned bone voids in the cranium and face as well as for simultaneously providing soft tissue reconstruction and/or augmentation for improved aesthetic symmetry and appearance of face and skull. Pterional or temporal voids or defects generally result from a chronic skull or lateral facial deformity along with a compromised temporalis muscle or soft tissue distortion from previous surgery. When muscle and fat atrophy occurs in the pterion or temporal face, temporal hollowing deformity generally results where there would be soft tissue but for the atrophy. The patient-specific craniofacial implants with dual-purpose herein are configured to have an augmented region adjacent the temporal region of the face and cranium in order to prevent and/or correct any such temporal hollowing deformity and to utilize this newfound space to strategically embed implantable neurotechnologies for improved outcomes.

Abstract: A spinal distraction system includes a distraction rod having a first end and a second end, the first end being configured for affixation to a subject's spine at a first location, the distraction rod having a second end containing a recess having a threaded portion disposed therein. The system further includes an adjustable portion configured for affixation relative to the subject's spine at a second location remote from the first location, the adjustable portion comprising a housing containing a magnetic assembly, the magnetic assembly affixed at one end thereof to a lead screw, the lead screw operatively coupled to the threaded portion. A locking pin may secure the lead screw to the magnetic assembly. An O-ring gland disposed on the end of the housing may form a dynamic seal with the distraction rod.

Abstract: The invention relates to an implant with a shank which is insertible into a bone cavity, which shank is made of a plastic, in particular of a bioincompatible plastic, and defines at least one bone contact face, wherein the bone contact face is provided or coated with a first biocompatible bone contact layer or bears a biocompatible bone contact layer, wherein the shank of the implant is intended to be anchored in the bone cavity without bone cement and wherein the first bone contact layer is formed entirely closed.

Abstract: A bone plate apparatus comprises a first plate comprising one or more openings configured for use in securing the first plate to a portion of a bone, a second plate comprising one or more openings configured for use in securing the second plate to a portion of a bone, and a linking segment. The first plate is connected to the linking segment at a first articulating joint, and the second plate is connected to the linking segment at a second articulating joint.

Abstract: Bone implants, including methods of use and assembly. The bone implants, which are optionally composite implants, generally include a distal anchoring region and a growth region that is proximal to the distal anchoring region. The distal anchoring region can have one or more distal surface features that adapt the distal anchoring region for anchoring into iliac bone. The growth region can have one or more growth features that adapt the growth region to facilitate at least one of bony on-growth, in-growth, or through-growth. The implants may be positioned along a posterior sacral alar-iliac (“SAI”) trajectory. The implants may be coupled to one or more bone stabilizing constructs, such as rod elements thereof.

Abstract: Disclosed herein are compositions, devices and methods for inactivating viruses, bacteria, and fungi. The compositions, methods, and devices may include coatings or slurries such as silicon nitride powder coatings or slurries for the inactivation of viruses, bacteria, and/or fungi.

Abstract: This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker.

Abstract: Provided herein are bio-absorbable, settable and homogenous multi-putty bone-adhesive compositions for medical use in tissue hemostasis, surgical repair and reconstruction. Also provided are improved methods of intraoperative use of said compositions for re-approximation of adjacent bone fragments to create a restored alignment and stabilize fracture line.

Abstract: A shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. Also, a process for repairing a cartilage defect with the cartilage matrix. The matrix is in the form of an osteochondral plug including a cartilage cap ad subchondral bone, wherein one or more gaps, slats, bores, or channels extend through the tidemark at the interface between the cartilage cap and the subchondral bone.

Abstract: An expandable device for expanding and supporting body tissue comprises an inferior endplate having an outer surface configured to contact one body tissue surface and a superior endplate having an outer surface configured to contact an opposing body tissue surface. The inferior endplate and the superior endplate are movable relative to each other in a direction of expansion. The device includes an elevator captively supported between the inferior endplate and the superior endplate for independent movement along the direction of expansion. In the first direction the elevator is moved toward said superior endplate to lift the superior endplate and expand the device. In the second direction the elevator moves away from said superior endplate toward said inferior endplate to create a space for insertion of an insert into the expanded device.

Abstract: There is an implant, comprising a plate portion at a first end, and a stem portion at a second end extending away from an end of the plate portion. In one embodiment, the plate portion comprises a first lobe with a first screw hole; and a second lobe with a second screw hole, wherein the first lobe is adjacent to the second lobe. There is also method of inserting an implant, comprising preparing a patient's bones, performing an osteotomy on the patient's bones to form a first bone segment and a second bone segment, aligning the first bone segment and the second bone segment and inserting an implant into an intramedullary canal in the second bone segment.

Abstract: A method for providing sub-elements of a multipart implant or a multi-part osteosynthesis prior to introducing same into a human and/or animal body, involves: A) detecting data of a patient for whom the implant and/or the osteosynthesis is intended; B) generating a model using the detected data; C) generating manufacture specifications for at least two or more sub-elements which can be combined so as to form an implant and/or an osteosynthesis on the basis of the generated model, said manufacture specifications comprising C1) a dimensioning of the sub-elements; and D) manufacturing the sub-elements on the basis of the manufacture specifications. The sub-elements can be assembled together so as to form an implant or an osteosynthesis.

Abstract: A bone screw comprising a shaft, in which the shaft comprises a bore that is configured to fit a magnet. In addition, a bone plate comprising apertures that can fit the bone screw. The bone plate may be fastened to bone using the bone screws, and the bone screws may be oriented to generate attractive or repulsive forces.

Abstract: The invention relates to a joint implant part of a joint endoprosthesis. The joint implant part comprises at least one first volume region, at least one second volume region and at least one third volume region. The at least one first volume region defines a bone contact surface region with at least one bone contact surface. The at least one second volume region defines a joint surface region with at least one joint surface. The at least one third volume region comprises neither a bone contact surface nor a joint surface. A modulus of elasticity in the at least one first and/or in the at least one second and/or in the at least one third volume region changes continuously or substantially continuously or discontinuously in at least one spatial direction.

Abstract: A link for interconnecting with one or more additional, similarly configured links so as to form a linkage for affixation to bone includes a receptacle member having an interior surface that defines a receptacle and further defines a bearing surface and an array of retention features that is arranged around the bearing surface. The link includes an insertion member that extends from the receptacle member and defines an exterior surface that at least partially surrounds a hole. A geometry of the exterior surface is configured to fit within a geometry of the receptacle. The exterior surface defines an annular recess configured to receive a retention member for engaging one or more of the arrayed retention features.

Abstract: Provided is an antibacterial biological implant capable of exhibiting superior antibacterial activity stably over a long period of time. The antibacterial biological implant 1 includes a substrate 2 made of a metal material and an anodized coating 3 provided on the substrate 2, the anodized coating 3 including an iodine-rich layer 31 located close to an interface S between the anodized coating 3 and the substrate 2.

Abstract: A multi-layered prosthetic element comprises a central body (1; 1?) of a substantially truncated conical shape and having a through axial cavity (2; 2?) open at both ends which gives the central body (1; 1?) a ring-shaped cross-section. The central body (1, 1?) comprises an outer portion (110; 110?), made of trabecular metal material, an inner portion (130; 130?), made of trabecular metal material, and an intermediate portion (120; 120?) made of metal material without significant porosity. The outer portion (110; 110?) and the inner portion (130; 130?) are integrally connected to the intermediate portion (120; 120?). The intermediate portion (120; 120?) is configured to mechanically resist to stresses transmitted to the inner portion (130; 130?) on one side and to the outer portion (110; 110?) on the other side.

Abstract: Reinforced biocomposite materials. According to at least some embodiments, medical implants are provided that incorporate novel structures, alignments, orientations and forms comprised of such reinforced bioabsorbable materials, as well as methods of treatment thereof.

Abstract: Various intramedullary implants, instruments, and methods are disclosed herein. In an example, a compression instrument is used to provide internal compression of bones adjoining a joint or bones spanning a fracture to cause compression of the joint or fracture.

Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.

Abstract: Described herein are devices and methods for fusion of adjacent vertebral bones using distractor platforms for exposure and resection of at least a portion of a facet joint, such as in performance of a TLiF procedure. In one embodiment, the distractor platform contains at least a first receptacle and/or extension adapted to couple to the implanted screw/bone marker, and the method includes advancing a threaded segment of a bone fastener assembly into the identified first pedicle of the first vertebral bone, the bone fastener assembly further comprises a second segment adapted to couple with a distraction platform, which is adapted to concurrently attach onto at least one tissue retention blade, and retain the tissue retention blade in the displaced position. Stabilization of a spinal segment is also provided by advancing a substantially concave orthopedic implant through an opening made in a posterior aspect of a disc space.

Abstract: Methods for improving the antibacterial characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant comprising a silicon nitride ceramic material may be subjected to a surface roughening treatment so as to increase a surface roughness of at least a portion of the biomedical implant to a roughness profile having an arithmetic average of at least about 500 nm Ra. In some implementations, a coating may be applied to a biomedical implant. Such a coating may comprise a silicon nitride ceramic material, and may be applied instead of, or in addition to, the surface roughening treatment process.

Abstract: A spinal implant includes a hollow body having a distal end, a proximal end, and a pair of lateral walls extending from the distal end to the proximal end, the lateral walls having a concave-shaped cross-section and having concave, non-threaded interior surfaces for defining an at least partially cylindrical internal space between the lateral walls. The hollow body has upper and lower faces that are inclined relative to one another, whereby a distance between the upper and lower faces decreases from a first lateral side of the hollow body to a second lateral side of the hollow body opposite the first lateral side. The implant includes an anchoring member having bone anchoring projections that is inserted into the hollow body. The anchoring member is rotatable for enabling the anchoring member to be screwed into the internal space of the hollow body.

Abstract: The present invention aims to provide a tissue regeneration substrate excellent in penetrability to cells as well as capable of effectively preventing cell leakage from the tissue regeneration substrate to accelerate tissue regeneration; and a method of producing the tissue regeneration substrate. The present invention relates to a tissue regeneration substrate including: a nonwoven fabric made of a bioabsorbable material, the tissue regeneration substrate having a laminated structure in which a layer containing a nonwoven fabric having an average pore size of 20 to 50 ?m and a layer containing a nonwoven fabric having an average pore size of 5 to 20 ?m are integrated.

Abstract: A pectus bar stabilizer insertion tool can include a first handle, a second handle, a first head, a second head, and a locking shaft. The first handle can include a first distal portion. The second handle can include a second distal portion, and the second handle can be pivotably coupled to the first handle. The first and second handles can be moveable between an open position and a closed position. The first head can be coupled to the first distal portion and can be engageable with a first portion of a stabilizer. The first head can include a driver engageable with a lock of the stabilizer. The second head can be coupled to the second distal portion and can be engageable with a second portion of the stabilizer. The locking shaft can be coupled to the driver and operable to lock and unlock the stabilizer to a pectus bar.

Abstract: Various modular implants and modular implant systems are disclosed herein, as are methods of implanting the same. The modular implant systems can include modular implants that are stacked on each other to define a modular implant system, which in an example can be used to replace or augment a void in bone. The modular implants can interact with an intramedullary implant to, for instance, assist with a fusion procedure.

Abstract: According to some aspects, a method is provided of removing debris from a liquid photopolymer in an additive fabrication device. According to some embodiments, a mesh of solid material may be formed in an additive fabrication device from a liquid photopolymer, and particles of debris present in the liquid photopolymer may adhere to the mesh. The debris may thereby be removed from the liquid photopolymer by removing the mesh from the additive fabrication device. The mesh may then be discarded.

Abstract: An implant and method for posterior sacroiliac fusion having a plate for placement across the posterior surface of the sacroiliac joint, a transverse pin to slide through the plate and transverse the joint as well as provide an aperture to receive bone graft, and a sacral screw to be inserted through the plate.

Abstract: A method includes forming a mixture including a therapeutic agent and a solid delivery medium, injecting the mixture into a reservoir within an orthopedic implant body, and storing the injected mixture in the reservoir.

Abstract: An implant and method for posterior sacroiliac fusion having a plate for placement across the posterior surface of the sacroiliac joint, a transverse pin to slide through the plate and transverse the joint as well as provide an aperture to receive bone graft, and a sacral screw to be inserted through the plate.

Abstract: Various modular implants and modular implant systems are disclosed herein, as are methods of implanting the same. The modular implant systems can include modular implants that are stacked on each other to define a modular implant system, which in an example can be used to replace or augment a void in bone. The modular implants can interact with an intramedullary implant to, for instance, assist with a fusion procedure.

Abstract: Fixation devices for tissue repair, for example sutures, surgical arrows, staples, darts, bolts, screws, buttons, anchors, nails, rivets, or barbed devices comprise at least one of angiogenic material; angiogenic precursor material which is capable of breaking down in vivo to form angiogenic material; or tissue-engineered material, which tissue-engineered material is capable of producing angiogenic material. In a preferred form, the material is incorporated into a polymer matrix having predetermined hydrophobicity to allow controlled release of angiogenic materials such as butyric or hydroxybutyric acid or salts thereof. Polymer matrix compositions comprising angiogenic materials and methods for tissue repair are also provided.

Abstract: A bone screw includes a main body having a proximal end and a distal end. The main body extends along a longitudinal axis. The main body has an externally threaded surface that includes at least one helically extending thread having a minor diameter and a major diameter, which major diameter is greater than the minor diameter. The thread includes at least two flank surfaces extending between the minor diameter and the major diameter. The minor diameter of the thread defines a central portion of the main body. The thread may include at least one aperture that extends along an aperture axis through the thread between the flank surfaces.

Abstract: Porous regions are formed using selected additive manufacturing techniques. The porous regions can assist in fibro-inductive regions and/or osteo-inductive regions. A prosthetic member can be formed completely with the additive manufacturing technique and/or the additive manufacturing techniques can be used to form an augment portion that is added to the prosthetic member formed separately.

Abstract: A moldable bone composition consists of a mixture of: cortical bone and cancellous bone. The cortical bone is formed in three portions, a mineralized shaving portion and a demineralized shaving portion and a mineralized powder portion. The cancellous bone is formed in a mineralized crushed cancellous portion. The portions are free-dried and mixed together to form a freeze-dried moldable bone composition.

Abstract: Methods and devices are provided for repairing a tear in a meniscus. A pair of fixation member each entailing a preformed knot configuration coupled together by a suture length. The fixation members are placed on the meniscal tissue with the suture length spanning the tear, the knot configurations are expanded to form anchoring knots and the suture length is shortened to close the tear.

Abstract: Provided herein are devices and methods for connecting a transcutaneous external prosthetic device to a bone, such as a bone of an amputee. The device is a two-piece transcutaneous implant device to provide reversible connection for ease of implantation, reliability, and relatively easy access for removal, while maximizing tissue ingrowth to reduce risk of infection and attendant adverse outcomes. The devices provided herein comprise a prosthetic interface and a bone anchor. A through-hole that traverses a longitudinal length of the prosthetic interface and at least a longitudinal portion of the bone anchor receives a fastener to reversibly connect the prosthetic interface to the bone anchor implanted in bone. A connector may connect to a failsafe element which, in turn, connects to an external prosthetic device.