Abstract: Tissue spacer implants and surgical methods for inserting the implants are disclosed. The implants may include a first cylindrical body with an outer surface, an axially extending hole, and a first end, a second cylindrical body with an outer surface and an axially extending hole, and an adjustment member with an outer surface, an axial hole, and at least one helical slot. The adjustment member axial hole may be adapted to receive the first cylindrical body and the adjustment member may be configured to be inserted into the axially extending hole of second cylindrical body. The implants may also include a travel mechanism for engaging the first cylindrical body, adjustment member, and second cylindrical body along the at least one helical slot to maintain a space between two bodies of tissue.

Abstract: An expandable implant includes a base member including a top surface, a first end, and a second end, and defining a central cavity positioned between the first end and the second end; an adjustable member including a top surface and at least one control channel, wherein the adjustable member is adjustably coupled to the base member and movable between a first, collapsed position, and a second, expanded position; a control shaft rotatable received by the base member, wherein rotation of the control shaft cause relative movement of the adjustable member relative to the base member; and at least one control member received on the control shaft and by the control channel, wherein rotation of the control shaft causes the control member to translate along the control shaft and along the control channel.

Abstract: Disclosed herein are implants and methods for filling voids in a cranium of a patient. A craniofacial implant that may be used for filling such voids may include at least first and second components each having outer and inner surfaces, the outer and inner surfaces being curved in an inferior to posterior direction and a medial to lateral direction. The first component includes a flange extending outwardly from a medial side surface thereof and the second component includes a recessed portion extending inwardly from a medial side surface thereof. The first and second components are preferably engageable to one another such that the medial side surfaces of the first and second components are adjacent one another and the flange of the first component is housed within the recessed portion of the second component.

Abstract: The invention relates to an implant (1) for sealing a defect (7c) in the annulus fibrosus (7a) of an intervertebral disc (7), comprising a retaining portion (3) for introducing into the defect (7c), a flexible sealing element which is connected to an inner end of the retaining portion, and a securing element (2) which is connected to the outer end of the retaining portion and which can be fixed to a vertebra (8) adjoining the intervertebral disc in order to hold the retaining portion (3) in a fixed position. According to the invention, this is achieved in that a securing limb (2), which is angled relative to the longitudinal axis of the retaining portion, is arranged on the outer end of the retaining portion (3), said securing limb being designed for laterally contacting a bony structure of a vertebra adjacent to the intervertebral disc and being securable on the vertebra by means of a fixing element which can be moved relative to the securing limb. The sealing element has inner reinforcements.

Abstract: An expandable fusion device may include a first endplate and a second endplate. The expandable fusion device may also include first and second ramps configured to mate with both the first and second endplates. The first ramp may include a mating feature having a first angle relative to a vertical axis, and the second ramp may include a mating feature having a second angle relative to the vertical axis such that the first angle is different from the second angle. In particular, the first and second ramps may be configured to provide for symmetrical expansion of the first and second endplates.

Abstract: The embodiments of the present disclosure relate to a spinal implant assembly having features to prevent or minimize fixation elements, such as screws, from being dislodged, or from backing out over time and with use. The spinal implant assembly may comprise an implantable body having first apertures for receiving fixation elements. A plate configured to nest against the posterior portion of the implantable body and comprising one or more second apertures can be provided. These second apertures permit access to the head portions of the fixation elements. One or more locking elements are then passed through the second apertures and engage the head portions of the fixation elements. In addition, the plate may comprise an adjustable arm to allow the plate to be used with implantable bodies of different size.

Abstract: Disclosed is an assembly and method for implant installation between adjacent vertebral bodies of a patient. The implant has a support body and a rotatable insert therein and the support body is curved for installation between adjacent vertebral bodies transforaminally. An installation instrument is also disclosed for removable attachment to implant and engagement with the rotatable insert to selectively permit rotation between the insert and the support body. The installation instrument extends along a longitudinal tool axis and when the installation instrument is in a first position the insert is rotationally fixed with respect to the support body and when the installation instrument is in a second position the support body may rotate with respect to the insert.

Abstract: A two-piece part may include a first portion defining at least one through hole and a second portion may be cast such that the second portion extends through the through hole thereby mechanically interlocking the first portion and the second portion together.

Abstract: A bone graft or spinal interbody device includes a frame member having two end segments for forming a chamber in the frame member, and two arms each include an outer end portion hinged to the outer end portion of the end segments of the frame member, and the inner end portions of the arms are hinged together for allowing the arms to be pivoted toward the frame member at an innermost folding position or away from the frame member to an outermost working position, and the arms are sprung away from the frame member to the outermost working position when the arms are pushed away from the frame member for a selected distance to an inner dead center (D).

Abstract: A spinal implant comprises a body including a first vertebral engaging surface and a second vertebral engaging surface. At least one of the surfaces including a posterior linear side and an anterior arcuate side. Systems and methods of use are disclosed.

Abstract: Apparatus and methods for providing spinal percutaneous delivery of an implant that can rigidly fixate the spinous process of a first superior bone and a second inferior bone of a functional spinal unit. In one aspect, the device comprises two bone abutment members connected via an interconnecting member. In another aspect, the method comprises implanting at least two spinal implant apparatus within a target disc space via an implantation apparatus. In another aspect, a placement instrument comprising an implant delivery segment, an anchor segment, and an articulating arm is disclosed.

Abstract: A modular implant for performing an intervertebral fusion on adjacent vertebral bodies in a patient including a first spacer portion, a second spacer and a container having a first end and a second end, the first end of the container constructed to operably engage a first spacer and the second end of the container constructed to operably engage the second spacer.

Abstract: A system and methods for promoting fusion across an intervertebral disc space, the system including a system of spinal fusion implants including a distal implant, a proximal implant and a medial implant positioned therebetween, wherein the medial implant has a flexible anterior wall capable of being deformed when a force is exerted upon it.

Abstract: An embodiment includes an expandable intervertebral body fusion device with two expansion wedges within a generally hollow main body. After implantation into the intervertebral disc space, the expansion wedges are simultaneously moved from the center of the device toward the ends, which flexes the arms of the cage and increases the size of the implant. This expansion stabilizes the device in the disc space and increases the disc height, thereby reducing foraminal compression of spinal nerves and creating a stable motion segment for eventual fusion. Other embodiments are described herein.

Abstract: Systems and methods for implanting a spinal implant between two vertebral bodies are provided. The spinal implant may include a main body adapted to rest between and adjacent to the two vertebral bodies, the main body having a cavity therein adapted to hold a filler and a cap adapted to connect to the main body where the cap is connectable after the main body has been inserted between the vertebral bodies and after the filler has been inserted into the cavity of the main body. The cap is securable to the main body by means of a securement member providing for a permanent connection between the main body and the cap.

Abstract: An intervertebral implant includes opposing upper and lower endplates that are configured to engage respective vertebral surfaces in an intervertebral space. The implant carries a plurality of bone fixation spikes that extend out from each endplate. The spikes define a plurality of outer surfaces that extend from a base to a tip. The spikes are laterally staggered, and have a height that increases along a longitudinal direction from the front toward the rear of the implant, and a define recess formed in at least one outer surfaces.

Abstract: An expandable spinal implant configured for positioning within the intervertebral space between adjacent vertebral bodies is disclosed. The spinal implant includes a first body, a second body, a ratchet, and a locking mechanism. The first and second bodies are pivotably affixed to each other on respective first ends thereof and are capable of movement relative to each other in a medial-lateral direction with respect to the adjacent vertebral bodies. The ratchet is pivotably supported within a slot defined in the first body and is capable of engaging the second body thereby permitting movement of the first and second body relative to each other in a first direction, but not in a second direction that is different than the first direction. A method of performing spinal surgery is also disclosed.

Abstract: An intervertebral implant includes a three-dimensional body and a securing plate. The three-dimensional body includes a front surface and a rear surface. The three-dimensional body further includes a plurality of boreholes for accommodating fixation elements. The intervertebral implant also includes a front plate disposed at the front surface of the three-dimensional body and has a plurality of boreholes. A securing plate can be fastened to the front plate.

Abstract: The present invention provides a process by which both non-tissue engineered and tissue engineered cartilaginous-like structures can be fabricated. The process of the present invention provides a method to produce electrospun nanofiber-anchored NP gels. The present invention provides a functional design for novel engineered IVD. The present invention provides a method for fabrication of both non-tissue and tissue engineered IVDs. These cartilaginous-like structures can be used to produce replacements for degenerated natural IVD. The method of the present invention uses electrospun PCL nanofiber mesh to anchor the NP. The method of the present invention can create angle-ply AF structure around the circumference of NP to mimic the architecture of native IVD. The method of the present invention anchors the top and bottom sides of NP by using non-woven aligned or random nanofiber mesh to create scaffold for the generation of endplate (EP) tissue.

Abstract: Improved flexible joint arrangements employ at least one flexure member that interfaces with wrapping surfaces defined on the bases to which the ends of the flexure member are connected. The flexure members are configured to define a traveling instantaneous axis of rotation that moves along a path defined by the interface of the flexure and the wrapping surfaces as the bases move relative to each other. The flexure members and the bases can be constructed of a monolithic material. The wrapping surfaces of the bases can be asymmetric in cross-sectional shape. The radius of curvature of the traveling instantaneous axis of rotation can be configured to change only in discrete quantum steps without reversals. In other embodiments, the flexible joint arrangement can be configured as one or more three bar linkages in which the middle bar is rigid and the outer bars are flexure members in accordance with the various embodiments.

Abstract: The invention is directed to an interbody fusion device comprises a load bearing component and a retention component and further comprises two bone screws that pass through the retention device and into the vertebral bodies. When implanted, the construct is flush with the anterior face of the vertebras and provides support and temporary fixation for the ultimate fusion of the vertebral bodies.

Abstract: An intervertebral prosthesis includes a body having first and second spaced apart major surfaces defining a longitudinal axis; a first aperture opening at one of the first and second major surfaces; a first anchoring element including a shaft having proximal and distal ends; a translator element coupled to the proximal end of the first anchoring element and having an engagement element that is releasibly engageable with a distal end of an external shaft element that enters the body through an aperture. The shaft element applies forces to the translator to: (i) move along a longitudinal axis within the body, (ii) translate the proximal end of the first anchoring element parallel to the longitudinal axis, and (iii) push the first anchoring element out through the first aperture.

Abstract: An intervertebral device comprises a plurality of struts that are rotatably associated with each adjacent strut to form a modifiable inner volume V for bone graft containment.

Abstract: An intervertebral prosthesis includes: a body including first and second spaced apart major surfaces defining a longitudinal axis extending substantially normal to said surfaces and at least anterior and posterior sidewalls extending therebetween, the first and second major surfaces for engaging endplates of first and second vertebral bones of a spine; an aperture extending from within the body, transversely to the longitudinal axis, and opening at a major surface; an anchoring element disposed within the aperture and including a threaded shaft; and a gear disposed adjacent to and in meshed, threaded communication with the threaded shaft of the anchoring element such that rotation of the gear causes rotation of the anchoring element, and a driving rotational force on the gear causes the anchoring element to rotate, deploy from the body, and thread into a vertebral bone transverse to the longitudinal axis of the body.

Abstract: An implant strip is disclosed. In some cases, the prosthesis can take the form of an implant strip that may be implanted through the use of a surgical procedure that minimizes incision sizes and may be considered less invasive than typical spinal implant procedures. The implant strip includes provisions for implantation, including teeth, spacing provisions, and various shapes.

Abstract: A dressing includes a silk protein layer and a hydrophilic glycoside compound, and the hydrophilic glycoside compound is coated on the silk protein layer. Furthermore, the invention also provides the use of a wound dressing comprising a silk protein layer and an active ingredient comprising a water extract of Gastrodia elata Blume, wherein the water extract containing gastrodin in a range from 0.33% to 0.67%.

Abstract: The present disclosure describes embodiments for treating a defect in a tissue, the tissue having internal and external surfaces. A device includes a first portion for positioning at one of the internal and external surfaces for applying a treatment force to the defect. In addition, the device has a second portion for applying a counter-force, where the second portion is operable to be positioned so that the counter-force is applied on the other of the internal and external surfaces, away from the defect so as to substantially avoid application of force at the defect. Furthermore, the device includes a coupling member for connecting the inner and outer portions. Methods of using the device are described, for example in an intervertebral disc having a herniation.

Abstract: An expandable interbody device for placement between adjacent vertebrae having an upper structure, a lower structure and a screw mechanism, wherein actuation of the screw mechanism moves the upper and lower structures between a collapsed configuration and an expanded configuration. A deployment tool couples to the expandable interbody device for positioning the device between adjacent vertebrae, actuating the screw mechanism and delivering a material to a chamber of the expandable interbody device.

Abstract: Intervertebral endoprosthesis discs suitable for surgical implantation between two vertebrae having and methods thereof. The prosthetic disc may have an endoprosthesis body including an anterior region and a posterior region designed to be positioned between a first vertebra and a second vertebra with a first and second movable insert positioned rotatably in anterior cavities and is rotatable to adjust the fasteners.

Abstract: A sacroiliac joint fusion system including a joint implant, anchor element and delivery tool. The joint implant includes a bore extending non-parallel to the implant longitudinal axis. The anchor element is for receiving in the bore. The delivery tool includes an implant arm and anchor arm. The implant arm distal end is releasably coupled to the joint implant proximal end so the implant arm longitudinal axis is coaxial or parallel with the implant body longitudinal axis. An anchor arm distal end is engaged to the anchor element proximal end. The anchor arm is coupled to the implant arm such that the anchor element longitudinal axis is coaxially aligned with the bore longitudinal axis when the implant arm distal end is releasably coupled with the implant proximal end and the anchor arm distal end is engaged with the anchor element proximal end.

Abstract: An implant for spinal fusion includes a base member, a closure member, pins, and recesses. The base member includes a U-shaped configuration with an open end defined by first and second free ends of first and second side walls extending away from an end wall. The closure member is configured to form an enclosed interior when coupled with the base member. The closure member includes first and second overlapping portions configured to engage the first and second free ends. First and second pins are embedded in a respective one of the first and second free ends. First and second recesses are formed in a respective one of the first and second overlapping portions. The pins cooperate with the recesses to align and frictionally couple the base member with the closure member.

Abstract: A vertically expandable intervertebral cage, deployment devices, and methods for using the same. The intervertebral cage can include a circuitous body at least partially enclosing an interior volume. The intervertebral cage can also include a front panel which can be formed into a wedge for facilitating implantation of the intervertebral cage into an intervertebral space. The intervertebral cage can be converted from an undeployed configuration, wherein the height of the intervertebral cage is reduced, to a deployed configuration, wherein the height of the intervertebral cage is increased to support end plates of the vertebrae. The intervertebral cage can be converted from the undeployed configuration to a deployed configuration by using a deployment device such as an implantation device and a guide wire. The deployment device can be used to impart a force upon the cage.

Abstract: Embodiments herein are generally directed to spinal implants, systems, apparatuses, and components thereof that can be used in spinal fusion and/or stabilization procedures, as well as methods of installation. The spinal implants may include an intervertebral spacer and a plate member.

Abstract: A bone fusion device for insertion between bones that are to be fused together, such as, for example, the vertebrae of a spinal column. The bone fusion device comprises at least one extendable tab and one or more tab extension assemblies. Each tab extension assembly is able to be adjusted in order to individually control the extension or contraction of a side of the tab thereby enabling adjustment of the height and/or angle of the tab with respect to the body of the bone fusion device. Each tab extension assembly is able to be individually adjusted such that the side controlled by each assembly is raised or lowered until the desired tab angle is achieved. The tab is advantageously positioned and angled to correspond to the vertebrae to help brace the device until the bone has fused.

Abstract: This disclosure is directed to a resilient interpositional arthroplasty implant for application into a knee joint to pad cartilage defects, cushion a joint, and replace or restore the articular surface, which may preserve joint integrity, reduce pain and improve function. The implant may endure variable joint compressive and shear forces and cyclic loads. The implant may repair, reconstruct, and regenerate joint anatomy, and thereby improve upon joint replacement alternatives. Rather than using periosteal harvesting for cell containment in joint resurfacing, the walls of this invention may capture, distribute and hold living cells until aggregation and hyaline cartilage regrowth occurs. The implant may be deployed into debrided joint spaces, molding and conforming to surrounding structures with sufficient stability to avoid extrusion or dislocation.

Abstract: An intervertebral scaffolding system is provided having a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state, the laterovertically-expanding frame having a stabilizer that slidably engages with the distal region of the laterovertically-expanding frame and is configured for retaining the laterovertically-expanding frame from a lateral movement that exceeds the expanded state. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse.

Abstract: Biomedical implants comprising portions made of disparate materials, such as intervertebral implants and related methods and instruments. In some embodiments, the implant may comprise a base portion comprising a first material and a secondary fastener portion comprising a second material having distinct physical properties relative to the first material. The secondary portion may wholly define a front end wall surface of the implant, and the base portion and the secondary portion may collectively define at least one of an upper surface and a lower surface of the implant.

Abstract: A spine stabilization and fusion system includes a lateral cage and a lateral block plate. The lateral cage is configured to be placed between an upper vertebra and a lower vertebra, and a face of the lateral cage includes one or more first holes configured to receive fasteners and a first shaft bore configured to receive a shaft. The lateral block plate includes one or more second holes extending from a lateral face of the lateral block plate to a medial face of the lateral block plate and configured to receive the fasteners. The one or more second holes are configured to align with the one or more first holes of the lateral cage. The lateral block plate also includes a second shaft bore configured to receive the shaft, where the second shaft bore is configured to align with the first shaft bore of the lateral cage.

Abstract: Embodiments herein are generally directed to spinal implants, systems, apparatuses, and components thereof that can be used in spinal fusion and/or stabilization procedures, as well as methods of installation. The spinal implants may include an intervertebral spacer and a plate member.

Abstract: The present invention relates to devices and methods for treating one or more damaged, diseased, or traumatized portions of the spine, including intervertebral discs, to reduce or eliminate associated back pain. In one or more embodiments, the present invention relates to an expandable interbody spacer. The expandable interbody spacer may comprise a first jointed arm comprising a plurality of links pivotally coupled end to end. The expandable interbody spacer further may comprise a second jointed arm comprising a plurality of links pivotally coupled end to end. The first jointed arm and the second jointed arm may be interconnected at a proximal end of the expandable interbody spacer. The first jointed arm and the second jointed arm may be interconnected at a distal end of the expandable interbody spacer. The first jointed arm and the second jointed arm may each be configured to fold inward in opposite directions to place the expandable interbody spacer in an expanded position.

Abstract: A spacer for separating bones of a joint, the spacer includes a frame having a longitudinal axis, and ramped surfaces. An endplate configured to engage a bone of the joint has ramped surfaces mateable with the ramped surfaces of the frame. When the endplate is moved relative to the frame in a direction along the longitudinal axis of the frame, the endplate is moved in a direction away from the frame to increase the height of the spacer. A second endplate configured to engage a second bone of the joint can be similarly configured.

Abstract: Embodiments herein are generally directed to spinal implants, systems, apparatuses, and components thereof that can be used in spinal fusion and/or stabilization procedures, as well as methods of installation. The spinal implants may include an intervertebral spacer and a plate member.

Abstract: Implants and methods for augmentation, preferably by minimally invasive procedures and means, of body tissue, including in some embodiments repositioning of body tissue, for example, bone and, preferably vertebrae are described. The implant may comprise one or more chain linked bodies inserted into the interior of body tissue. As linked bodies are inserted into body tissue, they may fill a central portion thereof and for example in bone can push against the inner sides of the cortical exterior surface layer, for example the end plates of a vertebral body, thereby providing structural support and tending to restore the body tissue to its original or desired treatment height. A bone cement or other filler can be added to further augment and stabilize the body tissue. The preferred implant comprises a single flexible monolithic chain formed of allograft cortical bone having a plurality of substantially non-flexible bodies connected by substantially flexible links.

Abstract: The present disclosure relates to a spinal implant. The spinal implant may be used for lateral insertion into an intervertebral disc space. For example, the spinal implant may include a spacer body to which a plate is fixed. The intervertebral spacer body may include a pair of opposite sides having a pyramid-shaped teeth to fuse to bone. The plate defines at least one upper and lower borehole that each receives a screw. Each screw attaches the plate to a vertebral body between which the intervertebral spacer body is inserted. The boreholes may include locking threads that are adapted to lock the screws into place by engaging complementary locking threads of head of the screw.

Abstract: An implant for therapeutically separating bones of a joint has two endplates each having an opening through the endplate, and at least one ramped surface on a side opposite a bone engaging side. A frame is slideably connected to the endplates to enable the endplates to move relative to each other at an angle with respect to the longitudinal axis of the implant, in sliding connection with the frame. An actuator screw is rotatably connected to the frame. A carriage forms an open area aligned with the openings in the endplates. The openings in the endplates pass through the carriage to form an unimpeded passage from bone to bone of the joint. The carriage has ramps which mate with the ramped surfaces of the endplates, wherein when the carriage is moved by rotation of the actuator screw, the endplates move closer or farther apart.

Abstract: Provided is a system and method for providing a non-binding allograft subtalar joint implant for surgical implant into a person's foot proximate to the ankle. This system for repair includes at least one sterile non-binding allograft subtablar joint implant provided as a pre-formed allograft rod plug “ARP” having a diameter about equal to an average width of a canal between a person's talus and calcaneus bones, the ARP being resiliently compressible and flexible. When snuggly disposed between the person's talus and calcaneus bones, the ARP compresses during normal use of the person's foot and maintains the canal in an anatomically correct alignment and reduces a tendency for abnormal motion between the person's talus and calcaneus bones. An associated method of use is also provided.

Abstract: An artificial disc is disclosed. The artificial disc may include a superior endplate having a bi-convex superior surface and a concave inferior surface, and an inferior endplate having a bi-convex inferior surface. The artificial disc may also include a core assembly disposed between the superior endplate and the inferior endplate, and a support assembly disposed on outer surfaces of both the superior endplate and the inferior endplate. The support assembly may be configured to couple the superior endplate to the inferior endplate.

Abstract: An interspinous process spacer includes a main body, a first wing, and a screw. The main body includes a first securing member extending from a top portion of the main body that engages a first vertebra and a bottom portion of the main body that engages a second vertebra. The first wing pivotably couples to a distal portion of the main body and includes a second securing member extending parallel to the first securing member to form a first clamp. The screw is positionable within the main body and includes a distal end that positions the first wing between a first position and a second position. The first clamp includes a first diameter in the first position and a second diameter in the second position.

Abstract: An expandable implant includes a body portion, a carriage portion, a deployment assembly, and an expandable portion. The deployment assembly and the expandable portion are attached to the carriage portion, and portions of the carriage portion are moveable out of and into the body portion. When the expandable implant is inserted into a disc space, the expandable portion is expandable to push the upper vertebral body and the lower vertebral body away from one another.

Abstract: The instant invention is a longitudinally adjustable corpectomy device which fits within the intervertebral distracted channel. A ratchet mechanism allows for an extendable member to adjust to a longer length to accommodate a distracted channel. The ratchet type mechanism allows the members to move in a unidirectional movement to prevent the two members from contracting once expanded.