Resilient Frame Patents (Class 623/2.18)
  • Patent number: 11517430
    Abstract: A biased cell configured to flex out-of-plane upon application of a lateral or circumferential force applied to the biased cell, the biased cell having an elongate member projecting axially from an apex of the biased cell that flexes out-of-plane concomitantly with out-of-plane flexion of the biased cell. An integral and monolithic hypotube is fashioned into a lattice structure having a plurality of biased cells and elongate members and is capable of being configured into a cardiac valve. Transluminally implantable cardiac valves configured for use in cardiac valve replacement and/or cardiac valve exclusion that are capable of percutaneous delivery on low-profile catheters having 15 French size or less. The implantable cardiac valves are fabricated of from a unitary metal material to form a lattice frame support having a main body portion and valve leaflet portion, and a plurality of elongate biasing arm members.
    Type: Grant
    Filed: January 24, 2022
    Date of Patent: December 6, 2022
    Assignee: Vactronix Scientific, LLC
    Inventor: Julio C. Palmaz
  • Patent number: 11517425
    Abstract: A device for implanting a heart prosthesis including a central body, a containment portion having one or more sub-components, and a release device for the central body capable of being inserted into a catheter. A device for assisting the connection operation between the central body and the sub-components of the containment portion includes an assembly of catheters, of which there are at least two catheters for each sub-component of the containment portion, the catheters being joined to each other over a portion thereof and having at least one free end for each catheter.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: December 6, 2022
    Assignee: INNOVHEART S.r.l.
    Inventors: Giovanni Righini, Cindy Trinh, Dong Ik Shin
  • Patent number: 11517436
    Abstract: An implant includes a clip and a clip-controller interface. The clip is disposed laterally from a central longitudinal axis of the implant, includes first and second arms articulatably coupled to each other, and sandwiches a leaflet of a heart valve between the first and second arms by articulation between the first and second arms, such that the second arm is disposed laterally from the first arm. The clip-controller interface is reversibly coupled to a clip controller of a delivery tool, and includes first and second portions. The first portion is linearly slidable by the clip controller. The second portion is articulatably coupled to the first portion and to the second arm, such that linear sliding of the first portion causes the second portion to (i) articulate with respect to the first portion, and (ii) push the second arm to articulate toward the axis. Other embodiments are also described.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: December 6, 2022
    Assignee: CARDIOVALVE LTD.
    Inventor: Gil Hacohen
  • Patent number: 11497634
    Abstract: A heart valve assembly includes an inner frame comprising a graft covering housing a prosthetic heart valve, wherein the graft covering extends around the prosthetic heart valve for providing sealing to the heart valve, an outer frame formed from a metallic material and defining a gridded configuration, and being secured to the graft covering by a plurality of stitches, and a sealing material positioned externally to the outer frame for providing sealing between the outer frame and a patient's anatomical wall to prevent paravalvular leaks. The sealing material includes a plurality of radially extending fibers that extend outwardly of the outer frame. The graft covering is made of polyester, polytetrafluoroethylene, expanded polytetrafluoroethylene, or a polymer.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: November 15, 2022
    Assignee: Aortic Innovations, LLC
    Inventor: Ali Shahriari
  • Patent number: 11484405
    Abstract: The present invention provides apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: November 1, 2022
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Amr Salahieh, Ulrich R. Haug, Hans F. Valencia, Robert A. Geshlider, Tom Saul, Dwight P. Morejohn, Kenneth J. Michlitsch
  • Patent number: 11464630
    Abstract: A stent device with skirt folds and a processing method thereof, a skirt folding method, and a heart valve. The stent device comprises a stent (1, 10) and a flexible skirt (2, 107), the skirt (2, 107) having an expanded state, in which the skirt is axially extended and surrounds the stent (1, 105) before release thereof, and a folded state, in which the skirt is driven by the deformation caused when the stent (1, 105) is released, collapses and folds axially along the released stent (1, 105) so as to form an annular peripheral leakage-blocking portion. The peripheral leakage prevention technology enables an interventional stent to fit to the inner wall of a vessel more snugly, such that the stent does not easily move and is more stable, thereby being suitable for more people, reducing additional risks of surgery and preventing complications such as peripheral leakage and thrombus.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: October 11, 2022
    Assignee: Venus Medtech (Hangzhou) Inc
    Inventors: Dajun Kuang, Jesse Jun Qi, Min Frank Zeng, Jincheng Yu, Lo Pham, Lai Nguyen
  • Patent number: 11464633
    Abstract: A cardiac implant system including a cardiac implant such as an annuloplasty ring, a prosthetic heart valve, or a valved conduit pre-assembled at the time of manufacture with devices for securing the implant to a heart valve annulus using knotless suture fasteners. The knotless suture fasteners may be embedded within a pliant sealing edge of the cardiac implant, or they may be positioned adjacent to the sealing edge. The knotless suture fasteners are spring-biased so as to grip onto annulus anchoring sutures pass to therethrough upon removal of a restraining device, such as a hypotube inserted within the suture fasteners. Guide tubes are assembled in line with the suture fasteners to permit introduction of suture snares that pass through the suture fasteners and through the sealing edge to facilitate capture of the pre-installed annulus anchoring sutures.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: October 11, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Salvador Marquez, Brian S. Conklin, Manouchehr A. Miraki, Yoon Hee Kwon
  • Patent number: 11452597
    Abstract: A replacement heart valve can have an expandable frame configured to engage a native valve annulus. A valve body can be mounted onto the expandable frame to provide functionality similar to a natural valve. The valve body has an upstream end and a downstream end, and a diameter at the downstream end is greater than a diameter at the upstream end.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: September 27, 2022
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Arshad Quadri, J. Brent Ratz
  • Patent number: 11446141
    Abstract: An implantable prosthetic device can include a frame that is radially expandable and compressible between a radially compressed configuration and a radially expanded configuration. The frame can have a first set of a plurality of struts extending in a first direction, and a second set of a plurality of struts extending in a second direction, and each strut of the first set of struts can be pivotably connected to at least one strut of the second set of struts. Each strut can be curved helically with respect to a first, longitudinal axis of the frame, and each strut can be curved with respect to a second axis that is perpendicular to the first, longitudinal axis of the frame.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: September 20, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Anatoly Dvorsky, Tamir S. Levi, Yair A. Neumann, Noa Axelrod Manela, Eitan Atias, Oren Cohen, Elazar Levi Schwarcz, Ofir Witzman, Noam Miller, Boaz Manash, Danny M. Garmahi
  • Patent number: 11432928
    Abstract: An implant for improving coaptation of an atrioventricular valve, the atrioventricular valve having a native first leaflet, a native second leaflet and an annulus and controlling blood flow from an upstream side to a downstream side of the valve, the implant comprising a support structure configured to be fixed to the annulus or to the native first leaflet, the implant further comprising a flexible artificial leaflet structure mounted to the support structure and comprising a rim section that is shaped to coapt with the native second leaflet, wherein said rim section comprises pockets that are open towards said downstream side and capable of being filled with blood from the downstream side each time the valve is closed.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: September 6, 2022
    Assignee: AVVIE GMBH
    Inventor: Werner Mohl
  • Patent number: 11419719
    Abstract: A prosthetic valve coaptation assist device includes an anchor and a single valve assist leaflet. The anchor may be a supporting ring frame, brace or arc structure and will usually be radially self-expandable so that it can expand against surrounding natural or prosthetic tissue. The valve assist leaflet may be made of pericardium or other biological or artificial material and is shaped like the native target valve leaflet. The valve assist leaflet is typically sized larger than the target natural or prosthetic leaflet so that after implantation a significant overlap of the device body occurs.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: August 23, 2022
    Assignee: MTEx Cardio AG
    Inventors: Jury Schewel, Karl-Heinz Kuck, Tom Saul
  • Patent number: 11406515
    Abstract: A heart valve assembly includes an inner frame comprising a graft covering housing a prosthetic heart valve, wherein the graft covering extends around the prosthetic heart valve for providing sealing to the heart valve, an outer frame formed from a metallic material and defining a gridded configuration, and being secured to the graft covering by a plurality of stitches, and a sealing material positioned externally to the outer frame for providing sealing between the outer frame and a patient's anatomical wall to prevent paravalvular leaks. The sealing material includes a plurality of radially extending fibers that extend outwardly of the outer frame. The graft covering is made of polyester, polytetrafluoroethylene, expanded polytetrafluoroethylene, or a polymer.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: August 9, 2022
    Assignee: Aortic Innovations, LLC
    Inventor: Ali Shahriari
  • Patent number: 11399940
    Abstract: Apparatus for treating blood flow regurgitation through a native heart valve (16) includes a selective occlusion device sized and configured to be implanted in the native heart valve (16) and selectively operating with at least one of the first or second native leaflets (16a, 16b) to allow blood flow through the native heart valve (16) when the heart cycle is in diastole and reduce blood flow regurgitation through the native heart valve (16) when the heart cycle is in systole. A clip structure (50) is coupled with the selective occlusion device. The clip structure (50) is configured to be affixed to a margin of at least one of the first or second native leaflets (16a, 16b) to secure the selective occlusion device to the native heart valve (16).
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: August 2, 2022
    Assignee: InValve Therapeutics, Inc.
    Inventor: Paul A. Spence
  • Patent number: 11389310
    Abstract: A transcatheter valve includes an outer seal made of outwardly extending fibers and is configured for transfemoral delivery within a patient.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: July 19, 2022
    Assignee: Aortic Innovations, LLC
    Inventor: Ali Shahriari
  • Patent number: 11382741
    Abstract: A prosthetic heart valve includes a non-collapsible annular frame extending between an inflow edge and an outflow edge, the frame having a plurality of annularly spaced commissure posts adjacent the outflow edge. A valve assembly including a plurality of leaflets is connected to the frame. The frame includes a weakened portion such that the frame is expandable from an initial condition having a first diameter to an expanded condition having a second diameter larger than the first diameter when a radially outward force is applied to an inner surface of the frame. A stabilizing strut may be positioned adjacent the weakened portion to reinforce the frame. The prosthetic heart valve may include an expandable ring positioned around the expandable frame.
    Type: Grant
    Filed: December 16, 2020
    Date of Patent: July 12, 2022
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Tracee Eidenschink, Xiangyang Zhang, Nicholas V. Jepson, Ryan J. Nesler
  • Patent number: 11382739
    Abstract: A replacement heart valve assembly has a stent frame and a replacement valve. The replacement valve has a plurality of leaflets and a valve frame. The leaflets are attached to the valve frame. Further, the assembly has a plurality of suspension struts attached to the stent frame and the valve frame. The valve frame is suspended within the stent frame via the suspension struts. In some embodiments, the assembly further has a sealing member attached to the stent frame to prevent leakage around the replacement heart valve assembly.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: July 12, 2022
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Roger N. Hastings, Mark L. Jenson
  • Patent number: 11369468
    Abstract: The present invention relates to an anchoring device (1) designed for anchoring a prosthetic heart valve inside a heart, comprising an extraventricular part (2) designed to be positioned inside an atrium or an artery and a ventricular part (3) designed to be positioned inside a ventricle, wherein the ventricular part comprises a double wall composed of an outer wall (4) and an inner wall (5) spaced apart at the level where the prosthetic heart valve is intended to be inserted, and wherein the anchoring device further comprises a predefined V-shaped groove (8) formed between the extraventricular part (2) and the ventricular part (3). The present invention also relates to an anchoring system (11) for anchoring a prosthetic heart valve inside a heart, comprising said anchoring device (1), a prosthetic heart valve support (12) and a prosthetic heart valve (13) connected to the prosthetic heart valve support (12).
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: June 28, 2022
    Assignee: TRICARES SAS
    Inventors: Coralie Marchand, Cecile Riou
  • Patent number: 11337804
    Abstract: A prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an annular valve body, as well as a plurality of ventricular anchoring legs and a plurality of atrial anchoring arms configured to extend radially outward from the annular valve body. The ventricular anchoring legs and grasping segments of the atrial anchoring arms may be configured to substantially restrict axial movement of the annular valve body within the native heart valve. In addition, anchoring segments of the atrial anchoring arms may be configured for lateral deformation relative to the native heart valve.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: May 24, 2022
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Meni Iamberger, Aviram Baum, Boaz Harari
  • Patent number: 11337798
    Abstract: A method for optimizing a shape of a replacement valve leaflet, wherein the shape of the replacement valve leaflet is determined by defining variable parameters of the replacement valve leaflet. The variable parameters may comprise: a valve height; a leaflet coaptation height, a first set of two control points for a first B-spline plane of symmetry; and a second set of two control points for a second B-spline plane tangent to a frame of the valve. The method may further comprise creating iterations of potential shapes of the replacement valve leaflet by changing one or more of the variable parameters using modeling software. The method may also comprise calculating the maximum stresses or strains on each of the potential shapes.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: May 24, 2022
    Assignee: Colorado Seminary Which Owns and Operates The University of Denver
    Inventors: Ali Nejatbakhsh Azadani, Mostafa Abbasi
  • Patent number: 11337810
    Abstract: This application relates to methods, systems, and apparatus for replacing native heart valves with prosthetic heart valves and treating valvular insufficiency. In a representative embodiment, a support frame configured to be implanted in a heart valve comprises a main body formed by formed by a plurality of inner members forming an inner clover and a plurality of outer members forming an outer clover. The support frame can include gaps located between inner members of the plurality of inner members and outer members of the plurality of outer members. The inner clover can be radially inside the outer clover, and the outer clover can have larger dimensions than the inner clover. The support frames herein can be radially expandable and collapsible.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: May 24, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Emil Karapetian, Maria Charles Vija Stanislaus, Gregory Bak-Boychuk, Christopher J. Olson, Cristobal R. Hernandez, William C. Brunnett, Netanel Benichou, Lauren R. Freschauf, Alexander J. Siegel, Stanton J. Rowe, Alison S. Curtis
  • Patent number: 11304800
    Abstract: A prosthesis is provided for implantation at a native semilunar valve of a native valve complex, the native valve complex having three semilunar sinuses and three native commissures. The prosthesis includes a valve prosthesis support, which comprises a support structure comprising exactly three engagement arms that meet one another at three respective junctures. The engagement arms are shaped so as define three peak complexes at the three respective junctures, and three trough complexes, each of which is between two of the peak complexes. Upon implantation of the prosthesis, each of the engagement arms is at least partially disposed within a respective one of the semilunar sinuses, such that each of the peak complexes is disposed distal to and in rotational alignment with a respective one of the native commissures, and each of the trough complexes is disposed at least partially within the respective one of the semilunar sinuses.
    Type: Grant
    Filed: December 22, 2019
    Date of Patent: April 19, 2022
    Assignee: MEDTRONIC VENTOR TECHNOLOGIES LTD.
    Inventors: Yossi Tuval, Raphael Benary, Ido Kilemnik
  • Patent number: 11291546
    Abstract: An implant is configured to be coupled to first and second native leaflets of a native heart valve of a patient. The implant includes a proximal collar, a distal collar, and first and second clasps. Each of the first and second clasps has first and second tissue-engaging portions that are (1) disposed distal to the proximal collar and proximal to the distal collar, (2) movable, with respect to each other, to clamp one of the leaflets between the first and second tissue-engaging portions of the clasp, and (3) movable, when clamped to the leaflet, toward and away from a central longitudinal axis of the implant. The implant includes fabric (i) extending distally from the proximal collar on either side of the central longitudinal axis, and (ii) coupled to the first and second clasps. Other embodiments are also described.
    Type: Grant
    Filed: May 3, 2021
    Date of Patent: April 5, 2022
    Assignee: CARDIOVALVE LTD.
    Inventors: Yossi Gross, Gil Hacohen
  • Patent number: 11291547
    Abstract: An implant is coupled to first and second native leaflets of a native heart valve of a patient. The implant includes a proximal collar, a distal collar, and first and second clasps. Each of the clasps has first and second tissue-engaging portions that are (1) disposed distal to the proximal collar and proximal to the distal collar, and (2) movable, with respect to each other, to clamp one of the leaflets between the tissue-engaging portions of the clasp. The implant is configured such that, when the leaflets are clamped by the clasps, the clasps form the first and second native leaflets into a double orifice, each orifice configured to function as a respective check-valve. Fabric extends distally from the proximal collar on either side of the central longitudinal axis, and is coupled to the clasps. Other embodiments are also described.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: April 5, 2022
    Assignee: CARDIOVALVE LTD.
    Inventors: Yossi Gross, Gil Hacohen
  • Patent number: 11284996
    Abstract: A prosthetic mitral valve may include a collapsible stent including a plurality of struts, a plurality of cells arranged in circumferential rows, the circumferential rows including a first row at an outflow end of the stent and a second row at an inflow end of the stent, and a plurality of strut intersections where at least two of the struts connect to one another. A cuff is attached to the stent. A prosthetic valve assembly is adapted to allow blood to flow in only one direction through the valve. The prosthetic valve assembly includes a first prosthetic leaflet having a first end attached directly to a first one of the strut intersections, and a second prosthetic leaflet having a first end attached directly to the first strut intersection. The first strut intersection is partially formed of one of the struts of one of the cells in the first row.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: March 29, 2022
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Jay Reimer, Katherine A. Ahmann, Mai Moua
  • Patent number: 11284995
    Abstract: A transcatheter valve having an expandable frame and a collapsible multi-portion skirt within the frame are provided with seams between the portions of the skirt that are located to cooperate with features of the frame and thereby reduce the exposure of the seams.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: March 29, 2022
    Assignee: Medtronic, Inc.
    Inventor: Alaena Maiorano
  • Patent number: 11284985
    Abstract: A loading device includes a locking collar assembly including a proximal end, a distal end, and a loading channel formed between the proximal end and the distal end. The device also includes a loading funnel coupled to the distal end of the locking collar assembly at a proximal end of the loading funnel. The loading funnel is configured to store a collapsible medical device in a partially collapsed state within a tapered interior volume of the loading funnel. The tapered interior volume decreases in volume from a distal end of the loading funnel to the proximal end of the loading funnel.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: March 29, 2022
    Assignee: MEDTRONIC CV LUXEMBOURG S.A.R.L.
    Inventors: Paraic Frisby, Niall Duffy
  • Patent number: 11253358
    Abstract: Disclosed in the present invention are a stent apparatus having a self-pleated skirt, a processing method therefor, a skirt pleating method, and a cardiac valve. The stent apparatus comprises a stent, and is further provided with a flexible skirt. The skirt comprises: an unfolded state, where the skirt extends axially and surrounds the periphery of the stent before release; and a stacked state, where the skirt is driven by deformation during release of the stent, and gathers and is stacked along an axial direction of the released stent to form an annular perivalvular leakage blocking part. The stent apparatus is further provided with a pull-wire which is merely threaded on the skirt, and the pull-wire may react to the radial deformation during the release of the stent to drive the skirt to enter the stacked state.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: February 22, 2022
    Assignee: Venus Medtech (Hangzhou), Inc.
    Inventor: Jesse Jun Qi
  • Patent number: 11241313
    Abstract: An apparatus for partially supporting a leaflet of a regurgitant heart valve comprises at least one subvalvular device including a subvalvular supporting portion including a leaflet-contacting upper supporter surface longitudinally spaced from an oppositely facing lower supporter surface. A supporter perimeter wall extends longitudinally between the upper and lower supporter surfaces, with at least a portion contacting a subvalvular cardiac wall adjacent to the heart valve. An anchor portion is adjacent to, and longitudinally spaced from, the upper supporter surface. The anchor portion includes a leaflet-contacting lower anchor surface longitudinally spaced from an oppositely facing upper anchor surface. A connector neck is interposed longitudinally between, and is directly attached to both of, the upper supporter surface and the lower anchor surface. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: February 8, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jose L. Navia, Samir Kapadia, Marwane Berrada
  • Patent number: 11234813
    Abstract: A side-deliverable prosthetic heart valve includes a valve frame defining an aperture that extends along a central axis and a flow control component mounted within the aperture and configured to permit selective blood flow therethrough. The prosthetic heart valve has a compressed configuration for side-delivery to a heart of a patient via a delivery catheter. The prosthetic heart valve is configured to transition to an expanded configuration when released from the delivery catheter for seating in a native annulus. The valve frame includes distal, proximal, and septal anchoring elements, each of which is insertable through the native annulus prior to seating the prosthetic heart valve therein. The septal anchoring element is configured to extend below the annulus and contact ventricular septal tissue to stabilize the prosthetic heart valve in the annulus when the prosthetic heart valve is seated in the annulus.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: February 1, 2022
    Assignee: VDyne, Inc.
    Inventor: Chad Perrin
  • Patent number: 11224507
    Abstract: A heart valve prosthesis for replacing a native mitral valve includes a self-expanding frame with a plurality of anchoring members disposed along the lower region. A valve body is positioned within the self-expanding frame and includes a plurality of leaflets configured to allow blood flow through the self-expanding frame in only one direction. A skirt surrounds the self-expanding frame and is spaced apart therefrom for contacting surrounding tissue and impeding blood flow around the self-expanding frame. The skirt may be reinforced with wires to help maintain a desired shape. The leaflets in the valve body are preferably connected to the self-expanding frame through one or more intermediate components such that the valve body is spaced radially inwardly from an inner surface of the self-expanding frame.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: January 18, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Matthew A. Peterson, Seung-Beom Yi, Siddharth Vad, Travis Zenyo Oba, Lauren R. Freschauf, Amanda French, Yaron Keidar, Yuanlong Du, Gregory Bak-Boychuk, Kevin M. Golemo, Alexander H. Cooper
  • Patent number: 11207176
    Abstract: Some embodiments of the present disclosure provide a stent-valve for transcatheter implantation to replace a cardiac valve. In some embodiments, the stent valve being compressible to a compressed state for delivery, and expandable to an operative state for implantation. In some embodiments, the stent-valve comprises a stent, a plurality of leaflets for defining a prosthetic valve, an inner skirt, an outer skirt, and a paravalve seal for sealing against surrounding tissue. In some embodiments, the paravalve seal comprising material that swells in response to contact with blood or components thereof.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: December 28, 2021
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Stephane Delaloye, Jacques Essinger, Jean-Luc Hefti, Youssef Biadillah, Luc Mantanus, Fabien Lombardi
  • Patent number: 11166809
    Abstract: Described embodiments are directed toward centrally-opening, leaflet valve devices and systems for transcatheter delivery having a two-piece valve body as well as methods of making and delivering the two-piece valve devices. A transcatheter valve includes a collapsed configuration and an expanded configuration. The transcatheter valve can further include an everted configuration and a non-everted configuration.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: November 9, 2021
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: William C. Bruchman, Cody L. Hartman
  • Patent number: 11141267
    Abstract: A prosthetic aortic valve includes an annular, annulus inflow portion that is designed to reside in or near the patient's native aortic valve annulus, and an annular, aortic outflow portion that is designed to reside in the patient's aorta downstream from at least a portion of the valsalva sinus. The annulus inflow portion and the aortic outflow portion are connected to one another by a plurality of connecting struts that are confined to regions near the commissures of the patient's native aortic valve. The connecting struts are designed to bulge out into the valsalva sinus to help anchor the prosthetic valve in place. The valve is circumferentially collapsible to a relatively small diameter for less-invasive delivery into the patient. The valve circumferentially expands to a larger operational diameter when deployed at the implant site.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: October 12, 2021
    Assignee: St. Jude Medical, LLC
    Inventor: Yousef F. Alkhatib
  • Patent number: 11135056
    Abstract: A prosthetic heart valve includes an annular frame including a plurality of strut members that is radially collapsible and expandable. A leaflet structure is situated within the frame, and includes a plurality of leaflets having opposing commissure tab portions on opposite sides of the leaflet. Each commissure tab portion is paired with an adjacent commissure tab portion of an adjacent leaflet to form one or more commissures. A commissure support element is positioned at each of the commissures, and comprise a first member and a second member that are separable from each other and configured to receive leaflets therebetween. The first and second members are detached from the frame and spaced radially inwardly from the frame such that the members contact the leaflets radially inward from the frame and limit movement of the leaflets so that they articulate at a location that is spaced radially inwardly from the frame.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: October 5, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Nikolay Gurovich, Michael Bukin, Alexey M. Tsypenyuk, Elena Sherman, Dikla Kersh, Boaz Manash, Liron Tayeb, Ziv Yohanan, Alexander Barash, Yair A. Neumann, Tomer Saar
  • Patent number: 11096781
    Abstract: A prosthetic heart valve can include a radially collapsible and expandable annular frame having a plurality of struts defining openings. The prosthetic heart valve can further include a plurality of leaflets that regulate the flow of blood through the frame. The prosthetic heart valve can also include a sealing member mounted on the frame and having an inner layer and an outer layer. At least the outer layer is mounted on the outside of the frame, and the inner layer covers at least the openings in the frame between adjacent cusp portions of adjacent leaflets and the inner layer does not cover one or more openings in the frame at locations facing the outflow surfaces of the leaflets to permit retrograde blood to flow through the one or more uncovered openings in the frame and into space between the outer layer and the frame.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: August 24, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Nikolay Gurovich, Michael Bukin, Elena Sherman, Tamir S. Levi, Ziv Yohanan, Gil Senesh, Dikla Kersh, Alexey M. Tsypenyuk, Waina Michelle Chu, Alexander Barash
  • Patent number: 11096782
    Abstract: Prosthetic heart valves are described herein that can provide clearance to the left ventricle outflow tract (LVOT), reduce the possibility of undesirable outflow gradients, and/or limit or prevent LVOT obstructions when implanted in the heart. In some embodiments, a prosthetic heart valve can include an outer frame having a cuff portion that is disposed at an angle (e.g., 80 degrees) relative to the vertical axis of a body portion of the outer frame, so that the prosthetic valve can seat securely in the annulus while not obstructing the ventricular outflow tract of the heart. In some embodiments, a prosthetic heart valve can alternatively, or additionally, include subvalvular components having a short profile, such that the prosthetic valve can seat securely in the annulus while not obstructing the ventricular outflow tract of the heart.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: August 24, 2021
    Assignee: Tendyne Holdings, Inc.
    Inventors: Mark Christianson, Michael Evans, Robert M. Vidlund
  • Patent number: 11083574
    Abstract: A prosthetic heart valve includes a valve frame (2), on which a plurality of valve leaflets (8) are fixed, and a fastening area for fastening in a blood vessel, which axially adjoins the valve frame (2). A stabilizing ring (14) is arranged in the fastening area. The stabilizing ring (14) defines a predetermined shape and a predetermined diameter of the fastening area and has at least one predetermined expansion point (22), whereby it is possible to expand the stabilizing ring (14) by an action of radial force on an inner circumference.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 10, 2021
    Inventor: Hans-Hinrich Sievers
  • Patent number: 11013595
    Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame having an inflow end, an outflow end, and a longitudinal axis. A leaflet structure is positioned within the frame and secured thereto, and a sealing element is secured to the frame. The sealing element includes a first woven portion extending circumferentially around the frame. The first woven portion includes a plurality of interwoven filaments. The sealing element further includes a second woven portion extending circumferentially around the frame and spaced apart from the first woven portion along the longitudinal axis of the frame. At least a portion of the filaments exit the weave of the first woven portion and form loops extending radially outwardly from the frame.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: May 25, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tamir S. Levi, Giolnara Pinhas, Liraz Marom, Elena Sherman, Noam Mizrahi, Delfin Rafael Ruiz, Sandip Vasant Pawar, Liron Tayeb
  • Patent number: 11013596
    Abstract: Prosthetic heart valve apparatus is adapted for delivery into a patient in a circumferentially collapsed condition, followed by circumferential re-expansion at the implant site in the patient. The apparatus includes an annular anchoring structure that can be implanted in the patient first. The apparatus further includes an annular valve support structure, which supports a flexible leaflet structure of the valve. The support and leaflet structures are initially separate from the anchoring structure, but they can be implanted in the patient by interengagement of the support structure with the already-implanted anchoring structure.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: May 25, 2021
    Assignee: St. Jude Medical, LLC
    Inventor: Yousef F. Alkhatib
  • Patent number: 11000372
    Abstract: The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance devices for implantation across the valve; a system including the coaptation enhancement element and anchors for implantation; a system including the coaptation enhancement element, and one or more of the following: transseptal sheath, anchor delivery catheter, implant delivery catheter, and clip delivery catheter; and methods for transcatheter implantation of a coaptation element across a heart valve.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: May 11, 2021
    Assignee: Polares Medical Inc.
    Inventors: Alexander K. Khairkhahan, Michael D. Lesh, Alan R. Klenk
  • Patent number: 10993804
    Abstract: A prosthetic heart valve includes a collapsible and expandable stent, a cuff attached to an annulus section of the stent, and leaflets attached to the cuff between a first location and a second location distal to the first location in a flow direction. The stent may include struts shaped to form a plurality of cells connected to one another in annular rows around the stent. The cuff may have top and bottom edges and may occupy a first group of the cells, such that cells above the top edge are open cells at least partially devoid of the cuff. The cuff may have a landing zone extending at least one-third of a length of the stent in the flow direction between the bottom edge of the cuff and a proximal end of a most proximal cell of the open cells when the stent is in an expanded use condition.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: May 4, 2021
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventor: Peter N. Braido
  • Patent number: 10987220
    Abstract: A heart valve therapeutic device (1) has an elongate anchor (7) wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar (70) arranged to provide a desired shape to the anchor (7) and it may be lockable. A prosthetic valve element (15) has leaflets (17) and is supported on the anchor by coupler (16, 50) at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers (16, 50) on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets (240) may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets (240).
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: April 27, 2021
    Assignee: The Provost, Fellows Foundation Scholars, and the Other Members of the Board, Of The College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin (TCD)
    Inventor: Martin Quinn
  • Patent number: 10959842
    Abstract: Described embodiments are directed toward centrally-opening leaflet prosthetic valves having a frame and a leaflet construct. Leaflet frame attachments for prosthetic valves include the leaflet construct being at least partially coupled to a frame outer side by a looped structure.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: March 30, 2021
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: David J. Arcaro, Stephen M. Probert, Dustin V. Dienno, Cody L. Hartman
  • Patent number: 10959843
    Abstract: A two component system for replacing mitral valves using a transcatheter approach. The first component uses a torus balloon to activate barbs into the mitral annulus after the first component stent frame has been delivered. A closed ring in the first component provides a landing site for delivery of a second component that contains replacement leaflets. The second component straddles the mitral annulus such that impingement upon the left ventricular outflow track does not occur. The second component frame contains open regions that help to prevent blood stagnation.
    Type: Grant
    Filed: September 30, 2018
    Date of Patent: March 30, 2021
    Inventors: William Joseph Drasler, William Joseph Drasler, II
  • Patent number: 10945839
    Abstract: Embodiments of the present disclosure provide a prosthetic heart valve usable with a heart valve delivery apparatus for delivery of the prosthetic heart valve to a native valve site via the human vasculature. In one embodiment, a self-expanding valve comprises an expandable stent that is shaped to maintain the valve in the aortic annulus against axial without anchors or retaining devices that engage the surrounding tissue. The prosthetic heart valve can have a curved shape that tapers inwardly from the inflow end to a reduced diameter section, increases in diameter from the reduced diameter section to an intermediate section, and then tapers from the intermediate section to the outflow end.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: March 16, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: David Alon, Netanel Benichou, Oded Meiri
  • Patent number: 10945841
    Abstract: Heart valve prostheses are provided for replacing a cardiac valve. The heart valve prosthesis includes a self-expanding frame including a first portion and a second portion. In the collapsed configuration, the first portion is positioned adjacent to the second portion. In the expanded configuration, the first portion moves to be positioned within an interior area of the second portion.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: March 16, 2021
    Assignee: Medtronic, Inc.
    Inventors: Igor Kovalsky, Ilia Hariton, Yossi Tuval, Nadav Yellin
  • Patent number: 10932903
    Abstract: Embodiments of an implantable prosthetic valve are disclosed. The valve can have an annular frame having a plurality of frame members and a skirt assembly. The skirt assembly can include a laminate having a fabric layer sandwiched between a first covering member and a second covering member. At least one surface of the fabric layer can be exposed at one or more windows in the second covering member. The skirt assembly can be coupled to the annular frame by a suture extending through the fabric layer at the one or more windows and around at least one of the plurality of frame members. Methods for making such an implantable prosthetic valve are also disclosed.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: March 2, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tamir S. Levi, Yair A. Neumann
  • Patent number: 10925724
    Abstract: Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve. In some embodiments the method includes the steps of: endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve; expanding the anchor to a deployed configuration; and locking the anchor in the deployed configuration.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: February 23, 2021
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Amr Salahieh, Brian D. Brandt, Dwight P. Morejohn, Ulrich R. Haug, Jean-Pierre Dueri, Hans F. Valencia, Robert A. Geshlider
  • Patent number: 10925595
    Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve may include an annular spacer configured for implantation with a native heart valve opening and a central valve section configured for disposal within the annular spacer. The central valve section may include at least one anchoring protrusion configured to anchor the central valve section against axial movement relative to the annular spacer. During deployment, the central valve section may be advanced downstream beyond the implanted annular spacer, and moved upstream until the anchoring protrusion engages the annular spacer.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: February 23, 2021
    Assignee: CARDIOVALVE LTD.
    Inventors: Gil Hacohen, Yossi Gross, Tal Reich
  • Patent number: 10918477
    Abstract: A prosthetic valve has a support structure that meets with a plurality of leaflets capable of transitioning between open and closed states. The support structure can include a base frame with a polymer coating and the leaflets can be artificial. The interface between the support structure and each leaflet can be at least partially convex when viewed from an exterior of the support structure along a normal to a plane formed by a central axis of the support structure and a central axis of the leaflet.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: February 16, 2021
    Assignee: FOLDAX, INC.
    Inventor: Jason G. Beith