Resilient Frame Patents (Class 623/2.18)
  • Patent number: 10786353
    Abstract: Disclosed replacement heart valves can be designed to be delivered to a native valve site while crimped on a delivery catheter. The crimped profile of the replacement valve can be minimized by, for example, separating a frame or stent structure from a leaflet structure, along the axial direction. Disclosed replacement valves can be transitioned from a delivery configuration, in which the crimped profile can be minimized, to an operating configuration. The replacement valve can be fully assembled in both the delivery and operating configurations. In some embodiments, the leaflets can be positioned outside of the stent in the delivery configuration, and positioned inside of the stent lumen in the operating configuration. Disclosed replacement valves can include a flexible sleeve coupling the leaflets to the stent and facilitating the transition to the operating configuration. Methods of implanting said replacement valves are also disclosed.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: September 29, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Netanel Benichou, Stanton J. Rowe, Sean Chow
  • Patent number: 10758344
    Abstract: Embodiments of the present disclosure are directed to prosthetic valves and methods of use thereof. In one implementation, a prosthetic valve may include an annular outer frame formed at least partially of struts intersecting at outer frame junctions and an inner frame situated within the outer frame. The inner frame may be formed at least partially of struts intersecting at inner frame junctions. The valve may include at least one inner frame tissue anchor extending from an inner frame junction. Outer frame junctions along a ventricular end of the outer frame may be angularly offset from inner frame junctions along a ventricular end of the inner frame.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: September 1, 2020
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Boaz Harari
  • Patent number: 10743993
    Abstract: Various embodiments of a prosthetic valve sizer and a method that utilizes such valve sizer are disclosed. In one or more embodiments, the prosthetic valve sizer can include a sizer body including an annular base and a post extending from the annular base. The prosthetic valve sizer can also include a resilient tip extending from the post of the sizer body. The resilient tip can include a material different from and more flexible than a material of the sizer body.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: August 18, 2020
    Assignee: Medtronic Inc.
    Inventor: Timothy Ryan
  • Patent number: 10743992
    Abstract: A prosthetic heart valve having an inflow end and an outflow end includes a stent having a collapsed condition, an expanded condition, and a plurality of cells arranged in circumferential rows. The stent may include one or more securement features. One securement feature may be an anchor arm having a body portion and a free end extending from the body portion, the body portion being coupled to a perimeter of one of the plurality of cells, with the free end extending toward the inflow end in an expanded condition of the anchor arm. Another securement feature may include a flange formed of a braided mesh and having a body portion coupled to the stent and a flared portion adjacent the inflow end of the prosthetic heart valve. A valve assembly is disposed within the stent and has a plurality of leaflets.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: August 18, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Mark Krans, Theodore Paul Dale, Andrea N. Para, Mathias Charles Glimsdale, Thomas M. Benson, Peter N. Braido
  • Patent number: 10729540
    Abstract: A single piece stent construction having a plurality of commissure posts, each of which extends upwardly from a solid ring along a bend line and generally along a central longitudinal axis of the stent.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: August 4, 2020
    Assignee: Medtronic, Inc.
    Inventors: Carol E. Eberhardt, Faisal Kalam
  • Patent number: 10716662
    Abstract: A stent-valve having a valve component and a stent component for housing the valve component, as well as associated methods and systems for delivery of the stent-valve via minimally-invasive surgery. The stent-valve can be configurable between two or more configurations to assist in delivery of the stent-valve to an implantation site of a patient.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: July 21, 2020
    Assignee: Boston Scientific Limited
    Inventors: Stephane Delaloye, Jean-Luc Hefti, Serge Delaloye
  • Patent number: 10709557
    Abstract: Embodiments of the present disclosure are directed to stents, valved-stents, (e.g., single-stent-valves and double stent/valved-stent systems) and associated methods and systems for their delivery via minimally-invasive surgery. The stent component comprises a first stent section (102) a second stent section (104) a third stent section (106) and a fourth stent section (108).
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: July 14, 2020
    Assignee: Symetis SA
    Inventors: Jacques Essinger, Serge Delaloye, Jean-Luc Hefti, Stephane Delaloye
  • Patent number: 10709553
    Abstract: A replacement heart valve may include a tubular anchor member actuatable between an elongated delivery configuration and an expanded deployed configuration, a buckle member fixedly attached to the anchor member, a post member axially translatable relative to the buckle member, the post member including a latch portion configured to engage the buckle member when the anchor member is in the deployed configuration, an actuator member including a pivot pin proximate a distal end thereof, the actuator member being releasably connected to a proximal end of the post member at the pivot pin, and a valve leaflet attached to the post member. The post member may be disposed distal of the anchor member when the anchor member is in the elongated delivery configuration.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: July 14, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Andrew J. H. Backus, Ali Salahieh, Ning Pan, Stanley A. Carroll
  • Patent number: 10709559
    Abstract: A delivery catheter for a stent. The delivery catheter may have a distal end and a proximal end. The distal end includes a stent attachment region adapted to receive a stent. The stent may be of the self-expanding type. The catheter further includes a handle at its proximal end and at least one sheath which may at least partially circumferentially cover the stent such as to retain it in a collapsed configuration. The sheath is coupled at its proximal end to an actuator located on the handle portion. The catheter further includes at least one radio-opaque indicator for indicating a rotational orientation of the delivery catheter and/or the stent when observed using medical imaging during implantation of the stent.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: July 14, 2020
    Assignee: BOSTON SCIENTIFIC LIMITED
    Inventors: Stephane Delaloye, Jean-Luc Hefti, Fabien Lombardi, Pierre Simonin
  • Patent number: 10702385
    Abstract: A native heart valve includes a first leaflet and a second leaflet. The first and second leaflets are arranged into a double-orifice by using the implant to couple a middle scallop of the first leaflet to a middle scallop of the second leaflet. Using at least one clip controller, each clip is opened by deflecting an arm of the clip away from a midline of the implant, and each clip is closed by deflecting the arm of the clip back toward the midline. The first and second clips are opened and closed independently of each other. Other embodiments are also described.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: July 7, 2020
    Assignee: CARDIOVALVE LTD.
    Inventor: Gil Hacohen
  • Patent number: 10695170
    Abstract: A hybrid prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be expanded post implant in order to receive and/or support an expandable prosthetic heart valve therein (a valve-in-valve procedure). The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible for delivery and expandable post-implant to facilitate a valve-in-valve procedure.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: June 30, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Brian S. Conklin, Qinggang Zeng
  • Patent number: 10639145
    Abstract: This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: May 5, 2020
    Assignee: Tendyne Holdings, Inc.
    Inventors: Robert Vidlund, Kemal Schankereli, Lucian Lozonschi, Georg Lutter
  • Patent number: 10624742
    Abstract: A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: April 21, 2020
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Juan F. Granada, Gary Erzberger, Michael P. Corcoran, Dan Wallace, Matteo Montorfano, Alaide Chieffo
  • Patent number: 10575944
    Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame including a plurality of angled strut members, and a skirt member secured to the frame. The skirt member includes a plurality of extension portions wrapped around at least one strut member adjacent the extension portions. The prosthetic valve further includes a cord member threaded through at least a portion of the plurality of extension portions to secure the skirt member to the at least one strut member.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: March 3, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tomer Saar, Michael Bukin, Elena Sherman, Alexander Barash, Yana Mayatskaya
  • Patent number: 10548722
    Abstract: A prosthetic heart valve includes a collapsible stent and a valve assembly disposed within the stent. A first cuff is disposed adjacent the stent. A second cuff having a distal edge facing the outflow end of the stent is disposed about the stent radially outward of the first cuff and the stent. The stent may include a plurality of fingers each having a first end coupled to a corresponding cell of the stent and a free end adapted to extend radially outward of the corresponding cell. The distal edge of the second cuff may be coupled to the fingers at spaced locations around the circumference of the stent to position the distal edge radially outward from the corresponding cells at the spaced locations. Various stent struts may be tapered to reduce the stent circumference in the collapsed condition, and to improve the fatigue resistance and/or bendability of the stent.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: February 4, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Kristen T. Morin, Gary Erzberger, Brett A. Hillukka, Kristopher H. Vietmeier
  • Patent number: 10537432
    Abstract: An apparatus for partially supporting a leaflet of a regurgitant heart valve comprises at least one subvalvular device including a subvalvular supporting portion including a leaflet-contacting upper supporter surface longitudinally spaced from an oppositely facing lower supporter surface. A supporter perimeter wall extends longitudinally between the upper and lower supporter surfaces, with at least a portion contacting a subvalvular cardiac wall adjacent to the heart valve. An anchor portion is adjacent to, and longitudinally spaced from, the upper supporter surface. The anchor portion includes a leaflet-contacting lower anchor surface longitudinally spaced from an oppositely facing upper anchor surface. A connector neck is interposed longitudinally between, and is directly attached to both of, the upper supporter surface and the lower anchor surface. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: January 21, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jose L. Navia, Samir Kapadia, Marwane Berrada
  • Patent number: 10531872
    Abstract: Embodiments of the present disclosure are directed to prosthetic heart valves and methods of use thereof. In one implementation, a prosthetic heart valve may include an annular spacer having a spacer opening therein and a disc-shaped wall configured to obstruct blood flow. The annular spacer may be configured for engaging with a native heart valve opening, such as the orifice of a mitral valve. The spacer opening may be sized to be smaller than the native heart valve opening. The prosthetic heart valve may also include a central valve section configured for disposal within the spacer opening. The central valve section may be separate from the annular spacer and may include one or more prosthetic valve leaflets.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: January 14, 2020
    Assignee: CARDIOVALVE LTD.
    Inventors: Gil Hacohen, Yossi Gross, Tal Reich
  • Patent number: 10512456
    Abstract: A transluminal sheath is advanced transfemorally into a left atrium of a heart of the subject. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the atrium, and toward a commissure of the mitral valve. A helix is implanted at the mitral valve by advancing the helix out of the surrounding-sheath and through the commissure into a left ventricle of the subject, such that the helix wraps around at least some chordae tendineae of the mitral valve. A prosthetic valve is collapsed into a collapsed state, and subsequently to implanting the helix and collapsing the prosthetic valve, the prosthetic valve is advanced, in its collapsed state, through the transluminal sheath to the mitral valve. The prosthetic valve is implanted in the mitral valve by expanding it such that the helix facilitates anchoring of the prosthetic valve and sealing of the commissure.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: December 24, 2019
    Assignee: CARDIOVALVE LTD.
    Inventors: Gil Hacohen, Yossi Gross, Tal Reich
  • Patent number: 10512538
    Abstract: A collapsible prosthetic heart valve includes a collapsible and expandable stent and a collapsible and expandable valve assembly. The stent has a proximal end and a distal end. A plurality of commissure points is disposed on the stent. The valve assembly is disposed within the stent and includes a plurality of leaflets. Each leaflet has a free edge. An end portion of the free edge of each leaflet is folded and sutured to a corresponding one of the plurality of the commissure points.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: December 24, 2019
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Yousef F. Alkhatib, Peter N. Braido
  • Patent number: 10485661
    Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: November 26, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Visith Chung, Da-Yu Chang, Brian S. Conklin, Grace Myong Kim, Louis A. Campbell, Donald E. Bobo, Jr., Myron Howanec, Jr., David S. Lin, Peng Norasing, Francis M. Tran, Mark Van Nest, Thomas H. Chien, Harvey H. Chen, Isidro L. Guerrero, Derrick Johnson, Paul A. Schmidt
  • Patent number: 10485659
    Abstract: A prosthetic heart valve using a pericardium is disclosed where: three hetero-biological tissue slices, which are extracted in a quadrangular shape from a bovine pericardium or a porcine pericardium, are prepared; each hetero-biological tissue slice is folded so as to form an inner tissue slice inside and an outer tissue slice outside, the outer tissue slice being longer than the inner tissue slice; each of the inner tissue slice and outer tissue slice is coupled by sewing in a semicircular shape with a first coupling thread such that each inner tissue slice forms a pulmonic valve slice inside the first coupling thread and a fixing slice outside the first coupling thread such that each hetero-biological tissue slice is formed in a cylindrical shape by allowing each slice to be adjacent to each other. The disclosed prosthetic heart valve has increased durability and prevents reverse blood flow.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: November 26, 2019
    Assignees: TAEWOONG MEDICAL CO., LTD.
    Inventors: Kyong Min Shin, Kang Sun Hong
  • Patent number: 10456246
    Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible to a limited degree for delivery and expandable post-implant to facilitate a valve-in-valve (ViV) procedure. The hybrid heart valves eliminate earlier structural bands, which both reduces manufacturing time and facilitates a ViV procedure.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: October 29, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Brian S. Conklin, Qinggang Zeng, Myron Howanec, Jr., Grace Myong Kim
  • Patent number: 10456247
    Abstract: A heart valve system, the system including a radially self-expandable tubular body and a valve. The tubular body having an inflow end and an outflow end, and the tubular body including a proximal-most end at the inflow end and a distal-most end at the outflow end. The tubular body including a plurality of arched beams at the outflow end of the tubular body such that the arched beams form the distal-most end of the tubular body. Connection points linking the inflow end of the tubular body and the arched beams, a number of connection points being equivalent to a number of the valve leaflets. Each arched beam being directly attached to an adjacent arched beam such that the arched beams are continuous along the entire circumference of the tubular body at the outflow end. The valve being coupled to the tubular body and including a plurality of valve leaflets.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: October 29, 2019
    Assignee: HIGHLIFE SAS
    Inventor: Malek Nasr
  • Patent number: 10441413
    Abstract: Embodiments of the present invention provide prosthetic valves having sealing members on the external surface thereof. The prosthetic heart valves of the present invention are preferably delivered by catheter directly through the apex of the heart or by other close range transcatheter delivery methods. Because these methods of implantation require a shorter length of catheter, a prosthetic valve can be more accurately oriented in the desired implantation location. Fluoroscopy can be used to further assist in orientation of the valve. The sealing members of the present invention can be positioned on the prosthetic valve such that, when the prosthetic valve is implanted in a native annulus, each provided sealing member is located adjacent to a commissural point of the native valve leaflets. Because the sealing members are precisely oriented on the prosthetic valve, a physician can ensure that the sealing members are aligned with the commissural points of the native valve leaflets.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: October 15, 2019
    Assignee: Medtronic, Inc.
    Inventor: Charles Tabor
  • Patent number: 10441417
    Abstract: A prosthetic heart valve includes a stent having an expanded condition and a collapsed condition. The stent includes a plurality of distal cells, a plurality of proximal cells, a plurality of support struts coupling the proximal cells to the distal cells, and at least one support post connected to a plurality of proximal cells. The proximal cells are longitudinally spaced apart from the distal cells. Various strut configurations and connections of the struts to the proximal cells and of the proximal cells to the support post improve stent flexibility and reduce stress in the valve leaflets.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: October 15, 2019
    Assignee: St. Jude Medical, LLC
    Inventors: Peter N. Braido, Yousef F. Alkhatib, Thomas M. Benson, Aaron J. Chalekian, Ott Khouengboua, Julia A. Schraut
  • Patent number: 10433957
    Abstract: A prosthetic heart valve includes a collapsible stent extending from an inflow end to an outflow end, and a cuff having an inflow end an outflow end. The stent includes first and second circumferential rows of cells defined by first and second pluralities of struts, respectively. The second circumferential row is positioned closer to the outflow end of the stent than the first circumferential row. At least one cell in the second circumferential row includes by a first strut opposed to a fourth strut and a second strut opposed to a third strut. A bridging feature in at least one cell in the second circumferential row includes first and second supplemental struts extending across an intermediate portion of the cell. The outflow end of the cuff is coupled to the stent along the bridging feature.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: October 8, 2019
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Sounthara (OTT) Khouengboua, Thomas Mark Benson, Xue Mei Li
  • Patent number: 10433952
    Abstract: A prosthetic mitral valve may be anchored in a native mitral valve. The prosthetic mitral valve preferably has a large anterior prosthetic leaflet that spans the entire width of the native anterior leaflet and the anterior prosthetic leaflet moves away from left ventricular outflow tract during systole to create a clear unobstructed outflow path.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: October 8, 2019
    Assignee: Neovasc Tiara Inc.
    Inventors: Randy Matthew Lane, Karen Tsoek-Ji Wong, Ian Fraser Kerr, Mark Segal
  • Patent number: 10426617
    Abstract: A replacement heart valve locking mechanism may include a buckle member fixedly attached to a tubular anchor member defining a central longitudinal axis, a post member axially translatable relative to the buckle member, and an actuator member releasably connected to the post member at an attachment point. The post member may include a latch portion configured to engage a catch formed in the buckle member such that movement of the post member distally relative to the buckle member is prevented. The attachment point may be disposed proximal of the latch portion. Circumferential translation of the latch portion about the central longitudinal axis may disengage the latch portion from the catch.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: October 1, 2019
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Andrew J. H. Backus, Takashi H. Ino, Crissly V. Crisostomo, Michael P. Calomeni, Anh Thu Pham
  • Patent number: 10426605
    Abstract: A mitral valve replacement device is adapted to be deployed at a mitral valve position in a human heart. The device has an atrial flange defining an atrial end of the device, a ventricular portion defining a ventricular end of the device, the ventricular portion having a height ranging between 2 mm to 15 mm, and an annulus support that is positioned between the atrial flange and the ventricular portion. The annulus support includes a ring of anchors extending radially therefrom, with an annular clipping space defined between the atrial flange and the ring of anchors. A plurality of leaflet holders positioned at the atrial end of the atrial flange, and a plurality of valve leaflets secured to the leaflet holders, and positioned inside the atrial flange at a location above the native annulus.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: October 1, 2019
    Assignee: Sino Medical Sciences Technology, Inc.
    Inventors: Jianlu Ma, Yong Huo, Tianzhu Li, Jinhong Zhao, Jianxiang Ma, Lei Meng
  • Patent number: 10363130
    Abstract: Expandable docking stations for docking an expandable valve can include a valve seat, one or more sealing portions, and one or more retaining portions. The valve seat can be unexpandable or substantially unexpandable beyond a deployed size. The one or more sealing portions are connected to the valve seat and extend radially outward of the valve seat. The one or more sealing portions are constructed to expand outward of the valve seat and provide a seal over a range of sizes. The one or more retaining portions are connected to the one or more sealing portions. The one or more retaining portions are configured to retain the docking station at a deployed position.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: July 30, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Dustin P. Armer, Michael D. Franklin, Sergio Delgado, Abhijeet Joshi, Dinesh L. Sirimanne, Russell T. Joseph, Eason Michael Abbott, Tram Ngoc Nguyen, Son V. Nguyen, Hien Tran Ngo, Vivian Tran, Charles L. Bowman, Stanton J. Rowe
  • Patent number: 10357360
    Abstract: Embodiments of the present disclosure are directed to prosthetic valves and methods of use thereof. In one implementation, an expandable prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may be expandable from a radially contracted state to a radially expanded state. The prosthetic valve may include an expandable outer frame and an inner frame with tissue anchors extending therefrom. The outer and inner frames may be configured and interconnected such that ventricular ends of the inner and outer frames are substantially aligned when the frames are in the radially expanded state and are not substantially aligned when the frames are in the radially contracted state.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: July 23, 2019
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Boaz Harari
  • Patent number: 10350062
    Abstract: A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity and a valve body. The expandable frame can include a frame body and a supplemental frame. The valve body can include a plurality of leaflets and one or more intermediate components. The one or more intermediate components can couple at least a portion of the leaflets to the expandable frame. The prosthesis can include an annular flap positioned around an exterior of the expandable frame.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: July 16, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Matthew A. Peterson, Seung-Beom Yi, Siddharth Vad, Travis Zenyo Oba, Lauren R. Freschauf, Amanda French, Yaron Keidar, Yuanlong Du, Gregory Bak-Boychuk, Kevin M. Golemo, Alexander H. Cooper
  • Patent number: 10321992
    Abstract: Prosthetic heart valve devices and associated methods for percutaneous or transcatheter heart valve replacement are disclosed herein. A heart valve prosthesis configured in accordance herewith includes a frame having a valve support and a plurality of support arms extending therefrom. The plurality of support arms may include a main support arm configured to extend from the valve support for capturing at least a portion of a valve leaflet of a native heart valve therebetween when the valve prosthesis is in an expanded configuration and deployed within the native heart valve. In addition, the plurality of support arms may include multiple supplemental support arms disposed about the circumference of the valve support that when deployed in the expanded configuration are configured to at least partially engage subannular tissue at the native heart valve.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: June 18, 2019
    Assignee: MEDTRONIC, INC.
    Inventors: Jason Quill, Padraig Savage, Joshua Dwork, Kshitija Garde, Sarah Ahlberg, Igor Kovalsky
  • Patent number: 10314706
    Abstract: A cardiac implant system including a cardiac implant such as an annuloplasty ring, a prosthetic heart valve, or a valved conduit pre-assembled at the time of manufacture with devices for securing the implant to a heart valve annulus using knotless suture fasteners. The knotless suture fasteners may be embedded within a pliant sealing edge of the cardiac implant, or they may be positioned adjacent to the sealing edge. The knotless suture fasteners are spring-biased so as to grip onto annulus anchoring sutures pass to therethrough upon removal of a restraining device, such as a hypotube inserted within the suture fasteners. Guide tubes are assembled in line with the suture fasteners to permit introduction of suture snares that pass through the suture fasteners and through the sealing edge to facilitate capture of the pre-installed annulus anchoring sutures.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: June 11, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Salvador Marquez, Brian S. Conklin, Manouchehr A. Miraki, Yoon H. Kwon
  • Patent number: 10314697
    Abstract: Described embodiments are related to a prosthetic valve for surgical placement with a sewing cuff durably attached to a frame. The durability of the attachment is accomplished by sandwiching a fabric between the frame and a composite material. The fabric extends beyond the frame base to form a sewing cuff that is integral to a frame assembly. The sewing cuff facilitates tissue ingrowth while tissue ingrowth is discouraged elsewhere around the frame.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: June 11, 2019
    Assignee: W. L. Gore & Associates, Inc.
    Inventor: Paul D. Gassler
  • Patent number: 10299919
    Abstract: A prosthetic heart valve includes a stent having an expanded configuration and a collapsed configuration, the stent in the expanded configuration having a longitudinal axis, an inflow end, an outflow end, a first portion adjacent the inflow end and a second portion adjacent the outflow end. The first portion includes a plurality of collapsible cells each having a perimeter and an open center; and the second portion includes a plurality of struts spaced from one another in an annular direction of the stent, the second portion of the stent being devoid of structure between annularly adjacent ones of the struts, whereby the annularly adjacent ones of the struts are not directly connected to one another. A valve assembly is supported by the stent.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: May 28, 2019
    Assignee: St. Jude Medical, LLC
    Inventor: Yousef F. Alkhatib
  • Patent number: 10299926
    Abstract: A prosthetic heart valve includes a collapsible and expandable stent extending from an inflow end to an outflow end and a plurality of prosthetic valve leaflets coupled to the stent. The prosthetic heart valve may also include a sealing ring coupled to the inflow end of the stent, the sealing ring comprising a tube extending circumferentially around the inflow end of the stent. The tube may be formed from a wire coiled into a repeating shape, such as a rectangle or a diamond, so that the tube is collapsible. A covering may at least partially surround the tube. The sealing ring may include a first filler positioned within the tube and/or a second filler positioned between the tube and the covering.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: May 28, 2019
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Kristen T. Morin, Andrea N. Para, Peter N. Braido, Sounthara Khouengboua, Thomas M. Benson, Saravana B. Kumar, Bruce Moseman, Gaurav Satam
  • Patent number: 10271940
    Abstract: An intraluminal device and method of fixation of an intraluminal device to resist distal migration in a mammalian lumen or hollow organ that is subject to peristalsis, according to an aspect of the invention, includes spaced apart wall portions connected with a connector. The wall portions are configured to the size and shape of a portion of the lumen or hollow organ and the connector is configured to be positioned against a wall of the lumen or hollow organ. The intraluminal device is positioned in a mammalian lumen or hollow organ that is subject to peristalsis. The device is fixed in the lumen or hollow organ against distal migration, wherein tissue lining the lumen or hollow organ bridges over the connector. The device is explanted after tissue bridges over the connector including separating the connector from one or both of the wall portions and withdrawing the connector axially from the tissue bridging over the connector.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: April 30, 2019
    Assignee: BFKW, LLC
    Inventors: James A. Foote, Frederick J. Walburn, Randal S. Baker
  • Patent number: 10238483
    Abstract: Devices and methods for assisting valve function, replacing venous valves, and predicting valve treatment successes. In at least one embodiment of an endograft valve device of the present disclosure, the device comprises an endograft body configured for expansion from a collapsed configuration to an expanded configuration within a luminal organ and comprising a first portion having a proximal end defining a proximal end aperture and a distal end defining a distal end aperture, the first portion tapering toward the distal end so that the distal end aperture has a relatively smaller cross-sectional area than the proximal end aperture when the valve device is expanded, and a valve portion positioned at or near the distal end of the first portion, the valve portion configured to receive fluid flowing through the distal end aperture of the first portion.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: March 26, 2019
    Assignee: 3DT Holdings, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 10231827
    Abstract: A transcatheter valve prosthesis including a tubular stent, a prosthetic valve component disposed within and secured to the stent, and a centering mechanism coupled to and encircling an outer surface of the tubular stent. The centering mechanism includes a self-expanding centering ring having an expanded diameter in the expanded configuration that is greater than an expanded diameter of the tubular stent in the expanded configuration and a plurality of self-expanding spokes radially extending between the tubular stent and the centering ring. The centering mechanism may include a base ring and/or a skirt. Alternatively, the centering mechanism includes a plurality of self-expanding loops. When each loop is in a delivery configuration the loop has a straightened profile that proximally extends from a proximal end of the tubular stent. When each loop is in an expanded configuration the loop has a U-shaped profile radially spaced apart from the tubular stent.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: March 19, 2019
    Assignee: MEDTRONIC VASCULAR, INC.
    Inventor: Bernard Mulvihill
  • Patent number: 10226338
    Abstract: A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: March 12, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Stanton J. Rowe, Larry L. Wood, Henry Bourang, George Bakis, Benjamin Spenser, Netanel Benichou, Assaf Bash, Yaron Keidar
  • Patent number: 10195441
    Abstract: Systems and methods are provided for optimizing hemodynamics within a patient's heart, e.g., to improve the patient's exercise capacity. In one embodiment, a system is configured to be implanted in a patient's body to monitor and/or treat the patient that includes at least one sensor configured to provide sensor data that corresponds to a blood pressure within or near the patient's heart; at least one adjustable component designed to cause blood to flow in a direction opposite to the normal direction (regurgitation) within the patient's heart; and a controller configured for adjusting the function of the at least one adjustable component based at least in part on sensor data from the at least one sensor.
    Type: Grant
    Filed: May 30, 2016
    Date of Patent: February 5, 2019
    Assignee: CARDIOFLOW TECHNOLOGIES, LLC
    Inventors: Daniel Walter Kaiser, Clayton A. Kaiser
  • Patent number: 10188514
    Abstract: A heart valve system, the system including a radially self-expandable tubular body, a valve, and a tubular fabric. The tubular body having an inflow end and an outflow end. The valve being coupled to the tubular body and including a plurality of valve leaflets. The valve leaflet being supported by only two beams of the plurality of beams, and connection points linking the inflow end of the tubular body and the plurality of beams. A number of connection points being equivalent to a number of the valve leaflets. Additionally, each beam of the plurality of beams being directly connected to an adjacent beam so that the plurality of beams extends the entire circumferential length of the tubular body at the outflow end.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: January 29, 2019
    Assignee: HIGHLIFE SAS
    Inventor: Malek Nasr
  • Patent number: 10149759
    Abstract: A device for placing in a cardiac valve to assist operation of natural cardiac valve leaflets, the device including a frame for anchoring the device, configured to be placed upstream of the cardiac annulus and shaped to prevent the frame from shifting downstream of the cardiac valve annulus, and at least one anchor extension attached to the frame, the anchor extension configured to extend through the leaflets of the cardiac valve at commissures of the cardiac valve and behind the natural leaflets, preventing the anchor extensions from shifting back from the downstream side of the annulus to the upstream side of the annulus. Related apparatus and methods are also described.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: December 11, 2018
    Assignee: Mitrassist Medical Ltd.
    Inventor: Gil Naor
  • Patent number: 10143552
    Abstract: A prosthetic mitral valve includes an anchor assembly, an annular strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The annular strut frame is disposed radially within the anchor assembly. An atrial end of the annular strut frame is attached to the anchor assembly such that a ventricular end of the annular strut frame is spaced away from the anchor assembly.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: December 4, 2018
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Dan Wallace, Spencer Noe, Peter Gregg, Juan F. Granada
  • Patent number: 10143549
    Abstract: Disclosed is an artificial valved conduit that is a composite valved graft comprising double sewing cuffs, which can be easily used in aortic root replacement. The composite valved graft comprises a valve and a conduit part connected to the valve. The conduit part comprises a sewing cuff positioned on the outer circumference thereof. The sewing cuff comprises a first sewing cuff and a second sewing cuff positioned below the first sewing cuff. Accordingly, a double suture is easily performed, so that it is possible to prevent the loss of blood after a surgery and to reduce surgical time at the same time.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: December 4, 2018
    Assignees: GIL MEDICAL CENTER, GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventor: Chul Hyun Park
  • Patent number: 10117741
    Abstract: Systems and methods for medical interventional procedures, including approaches to valve implantation. In one aspect, the methods and systems involve a modular approach to mitral valve therapy.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: November 6, 2018
    Assignee: Caisson Interventional, LLC
    Inventors: Cyril J. Schweich, Jr., Todd J. Mortier
  • Patent number: 10117742
    Abstract: A prosthetic heart valve includes a collapsible and expandable stent, a cuff attached to an annulus section of the stent, and leaflets attached to the cuff between a first location and a second location distal to the first location in a flow direction. The stent may include struts shaped to form a plurality of cells connected to one another in annular rows around the stent. The cuff may have top and bottom edges and may occupy a first group of the cells, such that cells above the top edge are open cells at least partially devoid of the cuff. The cuff may have a landing zone extending at least one-third of a length of the stent in the flow direction between the bottom edge of the cuff and a proximal end of a most proximal cell of the open cells when the stent is in an expanded use condition.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: November 6, 2018
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventor: Peter N. Braido
  • Patent number: 10098736
    Abstract: The implant (12) according to the invention comprises a tubular frame (16), a plurality of distal arms (18) capable of pressing on a first face of a tissue, and a plurality of proximal arms (20) having an end (62) connected to the frame and a free end (64) intended to press on a second face of the tissue to clamp the tissue. The implant comprises a first integral assembly including a first part (38) of the frame and the proximal arms (20), and a second integral assembly including a second part of the frame (40) and the distal arms (18), the first assembly and the second assembly being attached one on top of the other. The first part (38) of the frame is in the form of a proximal sleeve, extending longitudinally between a proximal end (41) and a distal end (43) of the sleeve. The connected end (62) of each proximal arm (20) is connected to the distal end (43) of the proximal sleeve (38), and the free end (64) of each proximal arm (20) extends beyond that distal end (43) of the proximal sleeve (38).
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: October 16, 2018
    Assignee: LABORATOIRES INVALV
    Inventors: Doron Carmi, Marcel Peltier
  • Patent number: RE47490
    Abstract: A prosthetic valve assembly and method of implanting same is disclosed. The prosthetic valve assembly includes a prosthetic valve formed by support frame and valve leaflets, with one or more tethers each having a first end secured to the support frame and the second end attached to, or configured for attachment to, to papillary muscles or other ventricular tissue. The tether is configured and positioned so as to avoid contact or other interference with movement of the valve leaflets, while at the same time providing a tethering action between the support frame and the ventricular tissue. The valve leaflets may be flexible (e.g., so-called tissue or synthetic leaflets) or mechanical.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: July 9, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: John F Migliazza, Hugues LaFrance, Harvey H Chen, Travis Zenyo Oba, Manouchehr A Miraki