Resilient Frame Patents (Class 623/2.18)
  • Patent number: 11141267
    Abstract: A prosthetic aortic valve includes an annular, annulus inflow portion that is designed to reside in or near the patient's native aortic valve annulus, and an annular, aortic outflow portion that is designed to reside in the patient's aorta downstream from at least a portion of the valsalva sinus. The annulus inflow portion and the aortic outflow portion are connected to one another by a plurality of connecting struts that are confined to regions near the commissures of the patient's native aortic valve. The connecting struts are designed to bulge out into the valsalva sinus to help anchor the prosthetic valve in place. The valve is circumferentially collapsible to a relatively small diameter for less-invasive delivery into the patient. The valve circumferentially expands to a larger operational diameter when deployed at the implant site.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: October 12, 2021
    Assignee: St. Jude Medical, LLC
    Inventor: Yousef F. Alkhatib
  • Patent number: 11135056
    Abstract: A prosthetic heart valve includes an annular frame including a plurality of strut members that is radially collapsible and expandable. A leaflet structure is situated within the frame, and includes a plurality of leaflets having opposing commissure tab portions on opposite sides of the leaflet. Each commissure tab portion is paired with an adjacent commissure tab portion of an adjacent leaflet to form one or more commissures. A commissure support element is positioned at each of the commissures, and comprise a first member and a second member that are separable from each other and configured to receive leaflets therebetween. The first and second members are detached from the frame and spaced radially inwardly from the frame such that the members contact the leaflets radially inward from the frame and limit movement of the leaflets so that they articulate at a location that is spaced radially inwardly from the frame.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: October 5, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Nikolay Gurovich, Michael Bukin, Alexey M. Tsypenyuk, Elena Sherman, Dikla Kersh, Boaz Manash, Liron Tayeb, Ziv Yohanan, Alexander Barash, Yair A. Neumann, Tomer Saar
  • Patent number: 11096782
    Abstract: Prosthetic heart valves are described herein that can provide clearance to the left ventricle outflow tract (LVOT), reduce the possibility of undesirable outflow gradients, and/or limit or prevent LVOT obstructions when implanted in the heart. In some embodiments, a prosthetic heart valve can include an outer frame having a cuff portion that is disposed at an angle (e.g., 80 degrees) relative to the vertical axis of a body portion of the outer frame, so that the prosthetic valve can seat securely in the annulus while not obstructing the ventricular outflow tract of the heart. In some embodiments, a prosthetic heart valve can alternatively, or additionally, include subvalvular components having a short profile, such that the prosthetic valve can seat securely in the annulus while not obstructing the ventricular outflow tract of the heart.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: August 24, 2021
    Assignee: Tendyne Holdings, Inc.
    Inventors: Mark Christianson, Michael Evans, Robert M. Vidlund
  • Patent number: 11096781
    Abstract: A prosthetic heart valve can include a radially collapsible and expandable annular frame having a plurality of struts defining openings. The prosthetic heart valve can further include a plurality of leaflets that regulate the flow of blood through the frame. The prosthetic heart valve can also include a sealing member mounted on the frame and having an inner layer and an outer layer. At least the outer layer is mounted on the outside of the frame, and the inner layer covers at least the openings in the frame between adjacent cusp portions of adjacent leaflets and the inner layer does not cover one or more openings in the frame at locations facing the outflow surfaces of the leaflets to permit retrograde blood to flow through the one or more uncovered openings in the frame and into space between the outer layer and the frame.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: August 24, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Nikolay Gurovich, Michael Bukin, Elena Sherman, Tamir S. Levi, Ziv Yohanan, Gil Senesh, Dikla Kersh, Alexey M. Tsypenyuk, Waina Michelle Chu, Alexander Barash
  • Patent number: 11083574
    Abstract: A prosthetic heart valve includes a valve frame (2), on which a plurality of valve leaflets (8) are fixed, and a fastening area for fastening in a blood vessel, which axially adjoins the valve frame (2). A stabilizing ring (14) is arranged in the fastening area. The stabilizing ring (14) defines a predetermined shape and a predetermined diameter of the fastening area and has at least one predetermined expansion point (22), whereby it is possible to expand the stabilizing ring (14) by an action of radial force on an inner circumference.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 10, 2021
    Inventor: Hans-Hinrich Sievers
  • Patent number: 11013596
    Abstract: Prosthetic heart valve apparatus is adapted for delivery into a patient in a circumferentially collapsed condition, followed by circumferential re-expansion at the implant site in the patient. The apparatus includes an annular anchoring structure that can be implanted in the patient first. The apparatus further includes an annular valve support structure, which supports a flexible leaflet structure of the valve. The support and leaflet structures are initially separate from the anchoring structure, but they can be implanted in the patient by interengagement of the support structure with the already-implanted anchoring structure.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: May 25, 2021
    Assignee: St. Jude Medical, LLC
    Inventor: Yousef F. Alkhatib
  • Patent number: 11013595
    Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame having an inflow end, an outflow end, and a longitudinal axis. A leaflet structure is positioned within the frame and secured thereto, and a sealing element is secured to the frame. The sealing element includes a first woven portion extending circumferentially around the frame. The first woven portion includes a plurality of interwoven filaments. The sealing element further includes a second woven portion extending circumferentially around the frame and spaced apart from the first woven portion along the longitudinal axis of the frame. At least a portion of the filaments exit the weave of the first woven portion and form loops extending radially outwardly from the frame.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: May 25, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tamir S. Levi, Giolnara Pinhas, Liraz Marom, Elena Sherman, Noam Mizrahi, Delfin Rafael Ruiz, Sandip Vasant Pawar, Liron Tayeb
  • Patent number: 11000372
    Abstract: The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance devices for implantation across the valve; a system including the coaptation enhancement element and anchors for implantation; a system including the coaptation enhancement element, and one or more of the following: transseptal sheath, anchor delivery catheter, implant delivery catheter, and clip delivery catheter; and methods for transcatheter implantation of a coaptation element across a heart valve.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: May 11, 2021
    Assignee: Polares Medical Inc.
    Inventors: Alexander K. Khairkhahan, Michael D. Lesh, Alan R. Klenk
  • Patent number: 10993804
    Abstract: A prosthetic heart valve includes a collapsible and expandable stent, a cuff attached to an annulus section of the stent, and leaflets attached to the cuff between a first location and a second location distal to the first location in a flow direction. The stent may include struts shaped to form a plurality of cells connected to one another in annular rows around the stent. The cuff may have top and bottom edges and may occupy a first group of the cells, such that cells above the top edge are open cells at least partially devoid of the cuff. The cuff may have a landing zone extending at least one-third of a length of the stent in the flow direction between the bottom edge of the cuff and a proximal end of a most proximal cell of the open cells when the stent is in an expanded use condition.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: May 4, 2021
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventor: Peter N. Braido
  • Patent number: 10987220
    Abstract: A heart valve therapeutic device (1) has an elongate anchor (7) wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar (70) arranged to provide a desired shape to the anchor (7) and it may be lockable. A prosthetic valve element (15) has leaflets (17) and is supported on the anchor by coupler (16, 50) at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers (16, 50) on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets (240) may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets (240).
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: April 27, 2021
    Assignee: The Provost, Fellows Foundation Scholars, and the Other Members of the Board, Of The College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin (TCD)
    Inventor: Martin Quinn
  • Patent number: 10959843
    Abstract: A two component system for replacing mitral valves using a transcatheter approach. The first component uses a torus balloon to activate barbs into the mitral annulus after the first component stent frame has been delivered. A closed ring in the first component provides a landing site for delivery of a second component that contains replacement leaflets. The second component straddles the mitral annulus such that impingement upon the left ventricular outflow track does not occur. The second component frame contains open regions that help to prevent blood stagnation.
    Type: Grant
    Filed: September 30, 2018
    Date of Patent: March 30, 2021
    Inventors: William Joseph Drasler, William Joseph Drasler, II
  • Patent number: 10959842
    Abstract: Described embodiments are directed toward centrally-opening leaflet prosthetic valves having a frame and a leaflet construct. Leaflet frame attachments for prosthetic valves include the leaflet construct being at least partially coupled to a frame outer side by a looped structure.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: March 30, 2021
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: David J. Arcaro, Stephen M. Probert, Dustin V. Dienno, Cody L. Hartman
  • Patent number: 10945839
    Abstract: Embodiments of the present disclosure provide a prosthetic heart valve usable with a heart valve delivery apparatus for delivery of the prosthetic heart valve to a native valve site via the human vasculature. In one embodiment, a self-expanding valve comprises an expandable stent that is shaped to maintain the valve in the aortic annulus against axial without anchors or retaining devices that engage the surrounding tissue. The prosthetic heart valve can have a curved shape that tapers inwardly from the inflow end to a reduced diameter section, increases in diameter from the reduced diameter section to an intermediate section, and then tapers from the intermediate section to the outflow end.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: March 16, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: David Alon, Netanel Benichou, Oded Meiri
  • Patent number: 10945841
    Abstract: Heart valve prostheses are provided for replacing a cardiac valve. The heart valve prosthesis includes a self-expanding frame including a first portion and a second portion. In the collapsed configuration, the first portion is positioned adjacent to the second portion. In the expanded configuration, the first portion moves to be positioned within an interior area of the second portion.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: March 16, 2021
    Assignee: Medtronic, Inc.
    Inventors: Igor Kovalsky, Ilia Hariton, Yossi Tuval, Nadav Yellin
  • Patent number: 10932903
    Abstract: Embodiments of an implantable prosthetic valve are disclosed. The valve can have an annular frame having a plurality of frame members and a skirt assembly. The skirt assembly can include a laminate having a fabric layer sandwiched between a first covering member and a second covering member. At least one surface of the fabric layer can be exposed at one or more windows in the second covering member. The skirt assembly can be coupled to the annular frame by a suture extending through the fabric layer at the one or more windows and around at least one of the plurality of frame members. Methods for making such an implantable prosthetic valve are also disclosed.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: March 2, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tamir S. Levi, Yair A. Neumann
  • Patent number: 10925724
    Abstract: Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve. In some embodiments the method includes the steps of: endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve; expanding the anchor to a deployed configuration; and locking the anchor in the deployed configuration.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: February 23, 2021
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Amr Salahieh, Brian D. Brandt, Dwight P. Morejohn, Ulrich R. Haug, Jean-Pierre Dueri, Hans F. Valencia, Robert A. Geshlider
  • Patent number: 10925595
    Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve may include an annular spacer configured for implantation with a native heart valve opening and a central valve section configured for disposal within the annular spacer. The central valve section may include at least one anchoring protrusion configured to anchor the central valve section against axial movement relative to the annular spacer. During deployment, the central valve section may be advanced downstream beyond the implanted annular spacer, and moved upstream until the anchoring protrusion engages the annular spacer.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: February 23, 2021
    Assignee: CARDIOVALVE LTD.
    Inventors: Gil Hacohen, Yossi Gross, Tal Reich
  • Patent number: 10918477
    Abstract: A prosthetic valve has a support structure that meets with a plurality of leaflets capable of transitioning between open and closed states. The support structure can include a base frame with a polymer coating and the leaflets can be artificial. The interface between the support structure and each leaflet can be at least partially convex when viewed from an exterior of the support structure along a normal to a plane formed by a central axis of the support structure and a central axis of the leaflet.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: February 16, 2021
    Assignee: FOLDAX, INC.
    Inventor: Jason G. Beith
  • Patent number: 10881768
    Abstract: A driveline for an implantable blood pump including a percutaneous outer tube configured to connect with the blood pump when the blood pump is implanted within a body of a patient and an external controller outside of the body of the patient and at least one ultra-violet light emitter coupled to the outer tube.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: January 5, 2021
    Assignee: HeartWare, Inc.
    Inventor: Fernando Casas
  • Patent number: 10874509
    Abstract: A prosthetic heart valve includes a collapsible and expandable stent having a proximal end and a distal end. A plurality of commissure attachment features (“CAFs”) is disposed on the stent, with each CAF including a body and a plurality of eyelets. The eyelets may be arranged in a single column or in a plurality of rows and columns. The prosthetic heart valve also includes a collapsible and expandable valve assembly including a plurality of leaflets connected to the plurality of commissure attachment features. The bodies of the CAFs may include a number of other features including, for example, a slot extending between columns of eyelets.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: December 29, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter N. Braido, Mina S. Fahim, Andrea L. McCarthy
  • Patent number: 10856981
    Abstract: The expandable sheath and methods of use disclosed herein are used to deliver a prosthetic device through a patient's vasculature. The sheath is constructed to be expandable in the circumferential direction, while maintaining sufficient stiffness in the longitudinal direction to withstand pushing and resist kinking. The sheath includes a plurality of curved arms extending outwardly from a longitudinally extending spine. The curved arms move away from the longitudinal axis of the sheath when pushed radially outwardly by a passing prosthetic device, and move back toward the longitudinal axis once the prosthetic device has passed.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: December 8, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: David Maimon, Eran Goldberg, Liron Tayeb
  • Patent number: 10849753
    Abstract: The invention relates to a heart implant comprising a tubular attachment element (1) for attaching an inflatable membrane (2), particularly an inflatable membrane (2) being coaxially positioned around the tubular attachment element (1) and fixed to it, the tubular attachment element (1) at one of its ends being split into several strips (4), the strips (4) extending away from the tubular attachment element (1) and forming an expandable cage (C), particularly for fixing the heart implant to the atrium of the heart by surface contact between an exterior surface of the expandable cage (C) and an interior atrium surface, each one of the strips (4) being split into two branches (4a, 4b, 4a?, 4b?, . . . ), each respective branch (4a) being merged into a new strip (5) together with another respective branch (4b?) of a neighboring strip (4) wherein such splitting and merging is performed one after the other at least three times and the number of strips (7) being formed of the last merged branches (6a, 6b, . . .
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: December 1, 2020
    Assignee: coramaze technologies GmbH
    Inventors: Niklas Maximilian Nathe, Torsten Scheuermann
  • Patent number: 10828153
    Abstract: A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: November 10, 2020
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Spencer Noe, Dan Wallace, Jonathan Oakden
  • Patent number: 10828154
    Abstract: A replacement heart valve implant defining a central longitudinal axis extending from an upstream end to a downstream end may include an expandable anchor member configured to shift between a delivery configuration and a deployed configuration, a circumferential support member distinct from and attached to the expandable anchor member, at least a portion of the circumferential support member extending downstream of the expandable anchor member, and a plurality of valve leaflets secured to the expandable anchor member. The plurality of valve leaflets may include a valve leaflet commissure movable from a first longitudinal position relative to the downstream end in the delivery configuration to a second longitudinal position relative to the downstream end in the deployed configuration.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: November 10, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Michael P. Calomeni, Takashi H. Ino, Ted Feldman
  • Patent number: 10820988
    Abstract: An expandable stent-valve has a stent component and a valve component, preferably an aortic valve component, a mitral valve component or a tricuspid valve component. The stent has, an outer surface area structured in a manner such that the surface area has a higher coefficient of friction between the outer surface and a duct wall than an untreated surface area of the stent component. The surface area is preferably structured with micro-incisions or micro-grooves.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: November 3, 2020
    Assignee: EPYGON
    Inventors: Marcio Scorsin, Enrico Pasquino
  • Patent number: 10786353
    Abstract: Disclosed replacement heart valves can be designed to be delivered to a native valve site while crimped on a delivery catheter. The crimped profile of the replacement valve can be minimized by, for example, separating a frame or stent structure from a leaflet structure, along the axial direction. Disclosed replacement valves can be transitioned from a delivery configuration, in which the crimped profile can be minimized, to an operating configuration. The replacement valve can be fully assembled in both the delivery and operating configurations. In some embodiments, the leaflets can be positioned outside of the stent in the delivery configuration, and positioned inside of the stent lumen in the operating configuration. Disclosed replacement valves can include a flexible sleeve coupling the leaflets to the stent and facilitating the transition to the operating configuration. Methods of implanting said replacement valves are also disclosed.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: September 29, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Netanel Benichou, Stanton J. Rowe, Sean Chow
  • Patent number: 10758344
    Abstract: Embodiments of the present disclosure are directed to prosthetic valves and methods of use thereof. In one implementation, a prosthetic valve may include an annular outer frame formed at least partially of struts intersecting at outer frame junctions and an inner frame situated within the outer frame. The inner frame may be formed at least partially of struts intersecting at inner frame junctions. The valve may include at least one inner frame tissue anchor extending from an inner frame junction. Outer frame junctions along a ventricular end of the outer frame may be angularly offset from inner frame junctions along a ventricular end of the inner frame.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: September 1, 2020
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Boaz Harari
  • Patent number: 10743992
    Abstract: A prosthetic heart valve having an inflow end and an outflow end includes a stent having a collapsed condition, an expanded condition, and a plurality of cells arranged in circumferential rows. The stent may include one or more securement features. One securement feature may be an anchor arm having a body portion and a free end extending from the body portion, the body portion being coupled to a perimeter of one of the plurality of cells, with the free end extending toward the inflow end in an expanded condition of the anchor arm. Another securement feature may include a flange formed of a braided mesh and having a body portion coupled to the stent and a flared portion adjacent the inflow end of the prosthetic heart valve. A valve assembly is disposed within the stent and has a plurality of leaflets.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: August 18, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Mark Krans, Theodore Paul Dale, Andrea N. Para, Mathias Charles Glimsdale, Thomas M. Benson, Peter N. Braido
  • Patent number: 10743993
    Abstract: Various embodiments of a prosthetic valve sizer and a method that utilizes such valve sizer are disclosed. In one or more embodiments, the prosthetic valve sizer can include a sizer body including an annular base and a post extending from the annular base. The prosthetic valve sizer can also include a resilient tip extending from the post of the sizer body. The resilient tip can include a material different from and more flexible than a material of the sizer body.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: August 18, 2020
    Assignee: Medtronic Inc.
    Inventor: Timothy Ryan
  • Patent number: 10729540
    Abstract: A single piece stent construction having a plurality of commissure posts, each of which extends upwardly from a solid ring along a bend line and generally along a central longitudinal axis of the stent.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: August 4, 2020
    Assignee: Medtronic, Inc.
    Inventors: Carol E. Eberhardt, Faisal Kalam
  • Patent number: 10716662
    Abstract: A stent-valve having a valve component and a stent component for housing the valve component, as well as associated methods and systems for delivery of the stent-valve via minimally-invasive surgery. The stent-valve can be configurable between two or more configurations to assist in delivery of the stent-valve to an implantation site of a patient.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: July 21, 2020
    Assignee: Boston Scientific Limited
    Inventors: Stephane Delaloye, Jean-Luc Hefti, Serge Delaloye
  • Patent number: 10709553
    Abstract: A replacement heart valve may include a tubular anchor member actuatable between an elongated delivery configuration and an expanded deployed configuration, a buckle member fixedly attached to the anchor member, a post member axially translatable relative to the buckle member, the post member including a latch portion configured to engage the buckle member when the anchor member is in the deployed configuration, an actuator member including a pivot pin proximate a distal end thereof, the actuator member being releasably connected to a proximal end of the post member at the pivot pin, and a valve leaflet attached to the post member. The post member may be disposed distal of the anchor member when the anchor member is in the elongated delivery configuration.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: July 14, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Andrew J. H. Backus, Ali Salahieh, Ning Pan, Stanley A. Carroll
  • Patent number: 10709557
    Abstract: Embodiments of the present disclosure are directed to stents, valved-stents, (e.g., single-stent-valves and double stent/valved-stent systems) and associated methods and systems for their delivery via minimally-invasive surgery. The stent component comprises a first stent section (102) a second stent section (104) a third stent section (106) and a fourth stent section (108).
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: July 14, 2020
    Assignee: Symetis SA
    Inventors: Jacques Essinger, Serge Delaloye, Jean-Luc Hefti, Stephane Delaloye
  • Patent number: 10709559
    Abstract: A delivery catheter for a stent. The delivery catheter may have a distal end and a proximal end. The distal end includes a stent attachment region adapted to receive a stent. The stent may be of the self-expanding type. The catheter further includes a handle at its proximal end and at least one sheath which may at least partially circumferentially cover the stent such as to retain it in a collapsed configuration. The sheath is coupled at its proximal end to an actuator located on the handle portion. The catheter further includes at least one radio-opaque indicator for indicating a rotational orientation of the delivery catheter and/or the stent when observed using medical imaging during implantation of the stent.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: July 14, 2020
    Assignee: BOSTON SCIENTIFIC LIMITED
    Inventors: Stephane Delaloye, Jean-Luc Hefti, Fabien Lombardi, Pierre Simonin
  • Patent number: 10702385
    Abstract: A native heart valve includes a first leaflet and a second leaflet. The first and second leaflets are arranged into a double-orifice by using the implant to couple a middle scallop of the first leaflet to a middle scallop of the second leaflet. Using at least one clip controller, each clip is opened by deflecting an arm of the clip away from a midline of the implant, and each clip is closed by deflecting the arm of the clip back toward the midline. The first and second clips are opened and closed independently of each other. Other embodiments are also described.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: July 7, 2020
    Assignee: CARDIOVALVE LTD.
    Inventor: Gil Hacohen
  • Patent number: 10695170
    Abstract: A hybrid prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be expanded post implant in order to receive and/or support an expandable prosthetic heart valve therein (a valve-in-valve procedure). The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible for delivery and expandable post-implant to facilitate a valve-in-valve procedure.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: June 30, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Brian S. Conklin, Qinggang Zeng
  • Patent number: 10639145
    Abstract: This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: May 5, 2020
    Assignee: Tendyne Holdings, Inc.
    Inventors: Robert Vidlund, Kemal Schankereli, Lucian Lozonschi, Georg Lutter
  • Patent number: 10624742
    Abstract: A method of delivering a prosthetic mitral valve includes delivering a distal anchor from a delivery sheath such that the distal anchor self-expands inside a first heart chamber on a first side of the mitral valve annulus, pulling proximally on the distal anchor such that the distal anchor self-aligns within the mitral valve annulus and the distal anchor rests against tissue of the ventricular heart chamber, and delivering a proximal anchor from the delivery sheath to a second heart chamber on a second side of the mitral valve annulus such that the proximal anchor self-expands and moves towards the distal anchor to rest against tissue of the second heart chamber. The self-expansion of the proximal anchor captures tissue of the mitral valve annulus therebetween.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: April 21, 2020
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Juan F. Granada, Gary Erzberger, Michael P. Corcoran, Dan Wallace, Matteo Montorfano, Alaide Chieffo
  • Patent number: 10575944
    Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame including a plurality of angled strut members, and a skirt member secured to the frame. The skirt member includes a plurality of extension portions wrapped around at least one strut member adjacent the extension portions. The prosthetic valve further includes a cord member threaded through at least a portion of the plurality of extension portions to secure the skirt member to the at least one strut member.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: March 3, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tomer Saar, Michael Bukin, Elena Sherman, Alexander Barash, Yana Mayatskaya
  • Patent number: 10548722
    Abstract: A prosthetic heart valve includes a collapsible stent and a valve assembly disposed within the stent. A first cuff is disposed adjacent the stent. A second cuff having a distal edge facing the outflow end of the stent is disposed about the stent radially outward of the first cuff and the stent. The stent may include a plurality of fingers each having a first end coupled to a corresponding cell of the stent and a free end adapted to extend radially outward of the corresponding cell. The distal edge of the second cuff may be coupled to the fingers at spaced locations around the circumference of the stent to position the distal edge radially outward from the corresponding cells at the spaced locations. Various stent struts may be tapered to reduce the stent circumference in the collapsed condition, and to improve the fatigue resistance and/or bendability of the stent.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: February 4, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Kristen T. Morin, Gary Erzberger, Brett A. Hillukka, Kristopher H. Vietmeier
  • Patent number: 10537432
    Abstract: An apparatus for partially supporting a leaflet of a regurgitant heart valve comprises at least one subvalvular device including a subvalvular supporting portion including a leaflet-contacting upper supporter surface longitudinally spaced from an oppositely facing lower supporter surface. A supporter perimeter wall extends longitudinally between the upper and lower supporter surfaces, with at least a portion contacting a subvalvular cardiac wall adjacent to the heart valve. An anchor portion is adjacent to, and longitudinally spaced from, the upper supporter surface. The anchor portion includes a leaflet-contacting lower anchor surface longitudinally spaced from an oppositely facing upper anchor surface. A connector neck is interposed longitudinally between, and is directly attached to both of, the upper supporter surface and the lower anchor surface. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: January 21, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jose L. Navia, Samir Kapadia, Marwane Berrada
  • Patent number: 10531872
    Abstract: Embodiments of the present disclosure are directed to prosthetic heart valves and methods of use thereof. In one implementation, a prosthetic heart valve may include an annular spacer having a spacer opening therein and a disc-shaped wall configured to obstruct blood flow. The annular spacer may be configured for engaging with a native heart valve opening, such as the orifice of a mitral valve. The spacer opening may be sized to be smaller than the native heart valve opening. The prosthetic heart valve may also include a central valve section configured for disposal within the spacer opening. The central valve section may be separate from the annular spacer and may include one or more prosthetic valve leaflets.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: January 14, 2020
    Assignee: CARDIOVALVE LTD.
    Inventors: Gil Hacohen, Yossi Gross, Tal Reich
  • Patent number: 10512538
    Abstract: A collapsible prosthetic heart valve includes a collapsible and expandable stent and a collapsible and expandable valve assembly. The stent has a proximal end and a distal end. A plurality of commissure points is disposed on the stent. The valve assembly is disposed within the stent and includes a plurality of leaflets. Each leaflet has a free edge. An end portion of the free edge of each leaflet is folded and sutured to a corresponding one of the plurality of the commissure points.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: December 24, 2019
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Yousef F. Alkhatib, Peter N. Braido
  • Patent number: 10512456
    Abstract: A transluminal sheath is advanced transfemorally into a left atrium of a heart of the subject. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the atrium, and toward a commissure of the mitral valve. A helix is implanted at the mitral valve by advancing the helix out of the surrounding-sheath and through the commissure into a left ventricle of the subject, such that the helix wraps around at least some chordae tendineae of the mitral valve. A prosthetic valve is collapsed into a collapsed state, and subsequently to implanting the helix and collapsing the prosthetic valve, the prosthetic valve is advanced, in its collapsed state, through the transluminal sheath to the mitral valve. The prosthetic valve is implanted in the mitral valve by expanding it such that the helix facilitates anchoring of the prosthetic valve and sealing of the commissure.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: December 24, 2019
    Assignee: CARDIOVALVE LTD.
    Inventors: Gil Hacohen, Yossi Gross, Tal Reich
  • Patent number: 10485659
    Abstract: A prosthetic heart valve using a pericardium is disclosed where: three hetero-biological tissue slices, which are extracted in a quadrangular shape from a bovine pericardium or a porcine pericardium, are prepared; each hetero-biological tissue slice is folded so as to form an inner tissue slice inside and an outer tissue slice outside, the outer tissue slice being longer than the inner tissue slice; each of the inner tissue slice and outer tissue slice is coupled by sewing in a semicircular shape with a first coupling thread such that each inner tissue slice forms a pulmonic valve slice inside the first coupling thread and a fixing slice outside the first coupling thread such that each hetero-biological tissue slice is formed in a cylindrical shape by allowing each slice to be adjacent to each other. The disclosed prosthetic heart valve has increased durability and prevents reverse blood flow.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: November 26, 2019
    Assignees: TAEWOONG MEDICAL CO., LTD.
    Inventors: Kyong Min Shin, Kang Sun Hong
  • Patent number: 10485661
    Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: November 26, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Visith Chung, Da-Yu Chang, Brian S. Conklin, Grace Myong Kim, Louis A. Campbell, Donald E. Bobo, Jr., Myron Howanec, Jr., David S. Lin, Peng Norasing, Francis M. Tran, Mark Van Nest, Thomas H. Chien, Harvey H. Chen, Isidro L. Guerrero, Derrick Johnson, Paul A. Schmidt
  • Patent number: 10456246
    Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible to a limited degree for delivery and expandable post-implant to facilitate a valve-in-valve (ViV) procedure. The hybrid heart valves eliminate earlier structural bands, which both reduces manufacturing time and facilitates a ViV procedure.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: October 29, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Brian S. Conklin, Qinggang Zeng, Myron Howanec, Jr., Grace Myong Kim
  • Patent number: 10456247
    Abstract: A heart valve system, the system including a radially self-expandable tubular body and a valve. The tubular body having an inflow end and an outflow end, and the tubular body including a proximal-most end at the inflow end and a distal-most end at the outflow end. The tubular body including a plurality of arched beams at the outflow end of the tubular body such that the arched beams form the distal-most end of the tubular body. Connection points linking the inflow end of the tubular body and the arched beams, a number of connection points being equivalent to a number of the valve leaflets. Each arched beam being directly attached to an adjacent arched beam such that the arched beams are continuous along the entire circumference of the tubular body at the outflow end. The valve being coupled to the tubular body and including a plurality of valve leaflets.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: October 29, 2019
    Assignee: HIGHLIFE SAS
    Inventor: Malek Nasr
  • Patent number: 10441417
    Abstract: A prosthetic heart valve includes a stent having an expanded condition and a collapsed condition. The stent includes a plurality of distal cells, a plurality of proximal cells, a plurality of support struts coupling the proximal cells to the distal cells, and at least one support post connected to a plurality of proximal cells. The proximal cells are longitudinally spaced apart from the distal cells. Various strut configurations and connections of the struts to the proximal cells and of the proximal cells to the support post improve stent flexibility and reduce stress in the valve leaflets.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: October 15, 2019
    Assignee: St. Jude Medical, LLC
    Inventors: Peter N. Braido, Yousef F. Alkhatib, Thomas M. Benson, Aaron J. Chalekian, Ott Khouengboua, Julia A. Schraut
  • Patent number: 10441413
    Abstract: Embodiments of the present invention provide prosthetic valves having sealing members on the external surface thereof. The prosthetic heart valves of the present invention are preferably delivered by catheter directly through the apex of the heart or by other close range transcatheter delivery methods. Because these methods of implantation require a shorter length of catheter, a prosthetic valve can be more accurately oriented in the desired implantation location. Fluoroscopy can be used to further assist in orientation of the valve. The sealing members of the present invention can be positioned on the prosthetic valve such that, when the prosthetic valve is implanted in a native annulus, each provided sealing member is located adjacent to a commissural point of the native valve leaflets. Because the sealing members are precisely oriented on the prosthetic valve, a physician can ensure that the sealing members are aligned with the commissural points of the native valve leaflets.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: October 15, 2019
    Assignee: Medtronic, Inc.
    Inventor: Charles Tabor