Polymers Patents (Class 623/23.58)
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Patent number: 8093313Abstract: A method for preparing a biocompatible polymeric composite includes modifying a first biocompatible polymer with a primer group to form a modified biocompatible polymer; blending the modified biocompatible polymer with a second biocompatible polymer and an inorganic material; allowing the primer group of the modified biocompatible polymer to react with the inorganic material to form a biocompatible polymeric composite. Such biocompatible polymeric composites may be formed into medical devices such as tissue growth scaffolds and bone growth scaffolds.Type: GrantFiled: October 27, 2009Date of Patent: January 10, 2012Assignee: Empire Technology Development LLCInventor: Seth Adrian Miller
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Patent number: 8083802Abstract: A joint prosthesis has a first component for cooperation with a first long bone, a second component for cooperation with a second long bone, and a bearing component positionable between the first component and the second component. The bearing component includes a reinforcing component and a polymeric material completely encapsulating the reinforcing component and molded thereto. The bearing component may be sterilized by a predominately surface sterilizing technology.Type: GrantFiled: March 18, 2008Date of Patent: December 27, 2011Assignee: Deput Products, Inc.Inventors: Rama Rao V. Gundlapalli, Mark Heldreth, Todd Smith, Albert Burstein
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Patent number: 8084077Abstract: A one step method for drug coating an interventional device is disclosed by mixing a drug with a phosphorylcholine-linked methacrylate polymer in a liquid and applying the mixture to an interventional device, such as a stent, in a single step.Type: GrantFiled: May 25, 2007Date of Patent: December 27, 2011Assignee: Abbott LaboratoriesInventors: Peter J. Tarcha, David Pecosky
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Patent number: 8062364Abstract: A method for treating arthritis of a joint includes identifying a bone lesion in a bone adjacent to the joint; and implanting in the bone a reinforcing member in or adjacent to the bone lesion. A kit for conducting the method includes: (a) at least one reinforcing member having a proximal face adapted to face the joint, a distal face adapted to face away from the joint, and a wedge-shaped edge adapted to pierce bone, wherein the at least one reinforcing member is planar and sterile; and (b) a container adapted to maintain the at least one reinforcing member sterile. Another kit includes: (a) a sterile fluid; (b) a syringe for injecting the fluid into a bone; (c) a curing agent adapted to cure the fluid to polymerize and/or cross-link; and (d) a container adapted to maintain the sterility of contents of the container.Type: GrantFiled: April 28, 2008Date of Patent: November 22, 2011Assignee: Knee Creations, LLCInventors: Peter F. Sharkey, Charles F. Leinberry
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Publication number: 20110282464Abstract: The present disclosure relates to a sprayable surgical implant. The implant includes a first component including microparticulates and a second component including at least one cross-linking reagent. The at least one cross-linking reagent reacts with the microparticulates to form the surgical implant.Type: ApplicationFiled: May 12, 2010Publication date: November 17, 2011Inventors: Timothy Sargeant, Joshua Stopek, Sebastien Ladet, Philippe Gravagna, Amin Elachchabi
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Publication number: 20110282463Abstract: The present invention relates to a medical tissue-binding material, especially a soft tissue-binding material capable of attaching to a soft biological tissue such as a bone reconstruction material or a transdermal terminal, and a method for preparation thereof. In particular, the present invention relates to a medical tissue-binding material which comprises a base material having calcium binding onto the surface, provided that the base material is not titanium or titanium alloy. Also, the present invention relates to a method for preparing a medical tissue-binding material which comprises soaking a base material into a calcium ion containing solution. Introduction of at least one group selected from the group consisting of hydroxyl, carboxyl, sulfonate, amino, silanol and phosphate to the surface of the base material is effective for said method.Type: ApplicationFiled: September 19, 2008Publication date: November 17, 2011Inventor: Kunio Ishikawa
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Patent number: 8030370Abstract: A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part. If applied to a finished polyethylene part, the irradiation and annealing must be accomplished with the polyethylene material not in contact with oxygen at a concentration greater than 1% oxygen volume by volume.Type: GrantFiled: April 9, 2010Date of Patent: October 4, 2011Assignee: How medica Osteonics Corp.Inventors: Aiguo Wang, John H. Dumbleton, Aaron Essner, Shi-Shen Yau
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Publication number: 20110218646Abstract: The present invention relates to a bone implant matrix, comprising a base matrix treated or to be treated with a reinforcing mixture containing at least a polymer. The described bone implant matrix is particularly suitable in the field of bone reconstructive surgery in general, orthopaedics, and in particular in oral surgery, maxillo-facial and dental implantology. Furthermore, a method for preparing the bone implant matrix is described.Type: ApplicationFiled: December 15, 2009Publication date: September 8, 2011Applicant: INDUSTRIE BIOMEDICHE INSUBRI S/AInventor: Gianni Pertici
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Patent number: 8012206Abstract: Osteochondral repair of damaged articular joint surfaces is achieved using implants in the form of cylindrical osteochondral plugs. The plugs have an articular surface formed on at least one end. If articular surfaces are provided on both ends of the implant, the articular surfaces have differently curved surfaces. The defective cartilage is removed to create a recipient socket for the implant. An implant sized to fit the recipient socket is chosen from a plurality of implants provided to the surgeon. The implants are preferably formed of a hydrogel material such as Salubria™, although metal or allograft implants can also be used.Type: GrantFiled: September 4, 2007Date of Patent: September 6, 2011Assignee: Arthrex, Inc.Inventor: Reinhold Schmieding
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Patent number: 8002843Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.Type: GrantFiled: February 4, 2004Date of Patent: August 23, 2011Assignee: Warsaw Orthopedic, Inc.Inventors: David Knaack, John Winterbottom, David Kaes, Todd Boyce, Lawrence A. Shimp
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Patent number: 7993401Abstract: Solid-state deformation processing of crosslinked high molecular weight polymers such as UHMWPE, for example by extrusion below the melt transition, produces materials with a combination of high tensile strength and high oxidative stability. The materials are especially suitable for use as bearing components in artificial hip and other implants. Treated bulk materials are anisotropic, with enhanced strength oriented along the axial direction. The material is oxidatively stable even after four weeks of accelerated aging in a pressure vessel containing five atmospheres of oxygen (ASTM F2003). Because of its oxidative stability, the deformation processed material is a suitable candidate for air-permeable packaging and gas sterilization, which has thus far been reserved for remelted crosslinked UHMWPE.Type: GrantFiled: February 21, 2008Date of Patent: August 9, 2011Assignee: Biomet Manufacturing Corp.Inventors: David W. Schroeder, Jordan H. Freedman, James E. Gunter, Brian D. Salyer, H. Gene Hawkins
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Publication number: 20110190903Abstract: A composite material for positioning in the anatomy to form a selected function therein. The composite may be resorbable over a selected period of time. The composite may allow for selected bone ingrowth as absorption of the composite occurs.Type: ApplicationFiled: January 31, 2011Publication date: August 4, 2011Applicant: Biomet Manufacturing Corp.Inventors: Mark D. BORDEN, Joseph M. HERNANDEZ, Edwin C. SHORS
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Patent number: 7985781Abstract: The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.Type: GrantFiled: July 9, 2008Date of Patent: July 26, 2011Assignee: Zimmer GmbHInventors: Orhun K. Muratoglu, Stephen H. Spiegelberg, Jeffrey W. Ruberti, Niels A. Abt
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Publication number: 20110153028Abstract: Osteochondral implants for repair of chondral defects and providing bone fixation through bone ongrowth and/or ingrowth. The implant is provided with a base allowing for bone ongrowth and/or ingrowth and a top attached to the base, the top being formed of a material having a compressive resistance similar to that of the cartilage. The material of the top is polycarbonate urethane, for example. The base may comprise a porous substrate for bony ingrowth formed of metal or PEEK and having a pattern porosity about similar to the porosity of cancellous bone. One side of the top attaches to the base for stability, and the other side of the top forms a surface for articulating with the opposing cartilage surface of the joint.Type: ApplicationFiled: December 22, 2010Publication date: June 23, 2011Inventor: Ricardo E. ALBERTORIO
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Publication number: 20110125284Abstract: A joint part (1) has a porous portion (2) that is defined by a multiplicity of solid regions where material is present and a remaining multiplicity of pore regions where material is absent, the locations of at least most of the multiplicity of solid regions being defined by one or more mathematical functions. The nature of the porous portion can be varied systematically by changing one or more constants in the mathematical functions and the part is made by a process of solid freeform fabrication.Type: ApplicationFiled: September 8, 2008Publication date: May 26, 2011Applicant: UNIVERSITY OF BATHInventors: Ruggero Gabbrielli, Irene Gladys Turner, Christopher Rhys Bowen, Emanuele Magalini
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Publication number: 20110046746Abstract: An embodiment of a bone stabilization and distraction system of the present disclosure includes a light-sensitive liquid; a light source for providing light energy; a light-conducting fiber for delivering the light energy from the light source to cure the light-sensitive liquid; a delivery catheter having a proximal end in communication with the light-conducting fiber and the light-sensitive liquid, an inner lumen for passage of the light-conducting fiber, and an inner void for passage of the light-sensitive liquid; and an expandable body removably engaging a distal end of the delivery catheter, wherein the expandable body has a closed end, a sealable open end, an inner cavity for passage of the light-sensitive liquid, an external surface and an internal surface, and wherein the expandable body has an insertion depth with a fixed dimension, a width with a fixed dimension, and a thickness with a changeable dimension.Type: ApplicationFiled: August 19, 2010Publication date: February 24, 2011Inventors: Robert A. Rabiner, Anthony W. O'Leary, Narissa Y. Chang, Arnold-Peter C. Weiss, Lionel C. Bainbridge
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Patent number: 7892291Abstract: An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may include, or have blended in, an additive, such as an osteoinductive factor, for example biocompatible ceramics and glass.Type: GrantFiled: October 7, 2008Date of Patent: February 22, 2011Assignee: Kensey Nash BVF Technology, LLCInventors: Douglas G Evans, Scott M. Goldman, Russell T. Kronengold
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Patent number: 7887598Abstract: An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may be “matched” to provide the implant with similar physical and/or chemical properties as the host tissue.Type: GrantFiled: October 27, 2007Date of Patent: February 15, 2011Assignee: Kensey Nash BVF Technology, LLCInventors: Douglas G Evans, Scott M. Goldman, Russell T. Kronengold
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Patent number: 7875296Abstract: A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.Type: GrantFiled: November 29, 2007Date of Patent: January 25, 2011Assignee: Depuy Mitek, Inc.Inventors: Francois Binette, Joseph J. Hammer, Krish Mukhopadhyay, Joel Rosenblatt
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Patent number: 7875342Abstract: The invention relates to porous ceramic composites incorporating biodegradable polymers for use as a bone substitute in the fields of orthopedics and dentistry or as a scaffold for tissue engineering applications. The porous ceramic composite implant for connective tissue replacement comprises a porous ceramic matrix having a biodegradable polymer provided on internal and external surfaces of the ceramic matrix. The biodegradable polymer allows for the passage and/or delivery of a variety of agents throughout the porous ceramic matrix and improves mechanical properties of the implant in vivo.Type: GrantFiled: September 24, 2002Date of Patent: January 25, 2011Inventors: Timothy J. N. Smith, Hendry Jason, M. Pugh Sydney, Smith Reginald
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Patent number: 7833278Abstract: An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery.Type: GrantFiled: October 20, 2008Date of Patent: November 16, 2010Assignee: Kensey Nash BVF Technology, LLCInventors: Douglas G Evans, Scott M. Goldman, Russell T. Kronengold
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Patent number: 7819925Abstract: An implantable prosthetic bearing is constructed of a composite material having a first layer and second layer. The first layer has an articulating surface defined therein, whereas the second layer has a engaging surface defined therein for engaging either another prosthetic component or the bone itself The first layer of the implantable prosthetic bearing is constructed of crosslinked polymer such as Ultra-High Molecular Weight Polyethylene, whereas the second layer of the implantable prosthetic bearing is constructed of polymer such as Ultra-High Molecular Weight Polyethylene that is either non-crosslinked or crosslinked to a lesser degree than the first layer. In such a manner, the first layer possesses mechanical properties which are advantageous in regard to the articulating surface (e.g., enhanced wear and oxidation resistance), whereas the second layer possesses mechanical properties which are advantageous in regard to the engaging surface (e.g., high ductility, toughness, and creep resistance).Type: GrantFiled: January 28, 2002Date of Patent: October 26, 2010Assignee: DePuy Products, Inc.Inventors: Richard King, Donald E. McNulty, Todd S. Smith
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Publication number: 20100262259Abstract: A novel method for producing a bone filling material is provided. The method comprises the steps of: (a) kneading ingredient comprising calcium-based material and material comprising binder; (b) molding a predetermined shape of the mixture obtained in step (a) with an injection molding machine having a mold; (c) removing the binder contained in the mold formed in step (b) (i.e., degreasing) to obtain a degreased body; (d) and heating and sintering the degreased body obtained in step (c) to obtain a sintered body.Type: ApplicationFiled: February 13, 2007Publication date: October 14, 2010Applicants: THE UNIVERSITY OF TOKYO, NEXT21 K.K., GAUSS K.K., National Institute of Advanced Industrial Science and TechnologyInventors: Yuichi Tei, Kay Teraoka, Shigeki Suzuki, Koutaro Shimizu, Katsuhisa Takane
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Patent number: 7812098Abstract: Disclosed is a bearing material of a medical implant comprising a polymer such as UHMWPE and a surface active agent that is not covalently bonded to the polymer. The bearing material has a reduced wear rate. Also disclosed is a method of reducing the wear rate of a polymeric bearing material of a medical implant when it articulates against a hard counterface in the presence of synovial fluid, the method comprising providing a surface active agent in the synovial fluid in close proximity to the bearing surface, the hard counterface, or both.Type: GrantFiled: March 31, 2006Date of Patent: October 12, 2010Assignee: Depuy Products, Inc.Inventors: Craig Ernsberger, Yen-Shuo Liao, Lawrence Salvati
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Publication number: 20100247672Abstract: A flowable, injectable composite that comprises mineralized allograft bone; and at least one degradable polyurethane that has a quasi-prepolymer and a resin mix, the resin mix having a polyester polyol and a catalyst; wherein the composite has a compression strength of greater than about 10 MPa and a modulus of greater than about 1 GPa.Type: ApplicationFiled: September 5, 2008Publication date: September 30, 2010Inventors: Scott A. Guelcher, Jerald Dumas
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Patent number: 7790779Abstract: The present invention provides partial and complete shielding approaches to alter the cross-linking characteristics of irradiated polymers, such as polyethylene. Irradiated polymers and fabricated articles, such as medical prosteses, comprising irradiated polymers also are provided.Type: GrantFiled: April 29, 2008Date of Patent: September 7, 2010Assignee: The General Hospital CorporationInventor: Orhun K. Muratoglu
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Patent number: 7785372Abstract: An artificial joint member made of a polymeric material including a portion made of a polymeric substance has a sliding surface composed of a polymer having phosphoryl choline groups. With such an arrangement, the artificial joint member is provided with a sliding part capable of keeping a satisfactory lubricating state for a long time.Type: GrantFiled: February 19, 2003Date of Patent: August 31, 2010Assignees: Kabushiki Kaisha Kobe Seiko ShoInventors: Kazuhiko Ishihara, Toru Moro, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Tomohiro Konno, Tomiharu Matsushita, Shuji Kusumoto
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Patent number: 7780896Abstract: A radiation crosslinked (50 kGy), pressure-treated UHMWPE material has been developed by applying compressive force on a crosslinked polymer in a direction orthogonal to an axial direction. The deformed material is then cooled while held in a deformed state. The resulting material is anisotropic, with enhanced strength oriented along the axial direction. The directionally engineered material is oxidatively stable even after four weeks of accelerated aging in a pressure vessel containing five atmospheres of oxygen (ASTM F2003). Because of its oxidative stability, the deformation processed material is a suitable candidate for air-permeable packaging and gas sterilization, which has thus far been reserved for remelted highly crosslinked UHMWPEs.Type: GrantFiled: December 4, 2008Date of Patent: August 24, 2010Assignee: Biomet Manufacturing Corp.Inventors: David W. Schroeder, Jordan H. Freedman, James E. Gunter, Brian D. Salyer, H. Gene Hawkins
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Publication number: 20100204800Abstract: The invention provides a multi-polymer hydrogel article having a first polymeric, water-swellable material and a second polymeric material, organized such that a first region substantially comprises the first polymeric, water-swellable material, a second region adjacent the first region comprises a mixture of the first polymeric, water-swellable material and the second polymeric material, and a third region adjacent the second region substantially comprises the second polymeric material. The article exhibits an increasing concentration gradient of the second polymeric material moving from the first region, through the second region, to the third region.Type: ApplicationFiled: April 26, 2010Publication date: August 12, 2010Applicant: ZIMMER, INC.Inventors: Brian Thomas, Kai Zhang
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Patent number: 7771527Abstract: A bone substitute composition includes glass flake and a hardenable material. The glass flake is a particle with an aspect ratio of, at least, 20:1. The preferred thickness of the glass flake is in the range from 200 to 1,000 nm and the average particle size is, preferably, from 20 to 60 ?m.Type: GrantFiled: September 4, 2007Date of Patent: August 10, 2010Inventor: Charles Watkinson
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Publication number: 20100174372Abstract: A plastic implant device for a mammal that contains a rare earth metal compound tracer and a method for detecting degradation such as wear of the implanted device are disclosed. The tracer can also be present with a separate antioxidant or the tracer compound can be can be the salt of a C6-C22 unsaturated carboxylic acid. The rare earth metal compound tracer is released when the prosthetic is worn down or otherwise degraded in the mammalian body in which it was implanted. The presence and amount of released tracer present in a body fluid or tissue sample measured and is proportional to the degree of degradation of the implant.Type: ApplicationFiled: October 9, 2009Publication date: July 8, 2010Applicant: RUSH UNIVERSITY MEDICAL CENTERInventors: Achim Kunze, Markus Wimmer
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Patent number: 7722896Abstract: Biocompatible polyarylates of diphenol compounds and poly(alkylene oxide) dicarboxylic acids, articles formed therefrom and therapeutic uses are disclosed.Type: GrantFiled: September 17, 2007Date of Patent: May 25, 2010Assignee: Rutgers, The State University of New JerseyInventors: Joachim B. Kohn, Satish Pulapura, Arthur Schwartz, Raman Bahulekar
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Patent number: 7714036Abstract: A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part. If applied to a finished polyethylene part, the irradiation and annealing must be accomplished with the polyethylene material not in contact with oxygen at a concentration greater than 1% oxygen volume by volume.Type: GrantFiled: December 9, 2008Date of Patent: May 11, 2010Assignee: Howmedica Osteonics Corp.Inventors: Aiguo Wang, John H. Dumbleton, Aaron Essner, Shi-Shen Yau
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Patent number: 7713637Abstract: Provided herein are a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.Type: GrantFiled: March 3, 2006Date of Patent: May 11, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Lothar W. Kleiner, Connie S. Kwok
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Patent number: 7704546Abstract: A method and apparatus for a prosthesis. At least a portion of the prosthesis is made from a ceramic that is treated with ion implantation, which causes a controllable, bilateral compressive stress of the ceramic. A diamond-like-coating (DLC) can be coated on the ceramic and in the same chamber as the ion implantation. After treating by ion implantation and coating with DLC, the ceramic will be strengthened and have a low coefficient of friction and thereby be made much less likely to fracture under load.Type: GrantFiled: September 1, 2005Date of Patent: April 27, 2010Assignee: Southwest Research InstituteInventor: Geoffrey Dearnaley
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Publication number: 20100076572Abstract: A synovial joint implantable apparatus for the reconstruction of skeletal defects with a flexible member, which is preferably resorbable, attached to a rigid structural prosthesis such as a total hip or total knee replacement implant. The cavitary space defined and surrounded by the flexible member is filled with osteoconductive and/or inductive materials which eventually matures into new column of bone. The prosthesis is supported by the bed of graft material surrounding it and is gradually unloaded as the bed matures into solid bone. The fixation of the prosthesis into native bone depends on the specific implant and the anatomic area of its use. The flexible member is secured to the margins of the prosthesis using rails, runners, sutures, or other attachment devices that prevent the escape of the bone graft and maintain an initial column of support for the implant.Type: ApplicationFiled: November 25, 2009Publication date: March 25, 2010Inventor: Amir A. Jamali
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Patent number: 7683133Abstract: Disclosed is a bearing material of a medical implant, which is an ultrahigh molecular weight polyethylene (UHMWPE) composite. The composite comprises, for example, UHMWPE and a polyethylene copolymer having a polymer backbone and pendant hydrophilic groups or pendant surface active agents that are attached to the polymer backbone. Also disclosed are methods for preparing bearing materials. The bearing material has one or more advantageous properties including reduced immune response, reduced wear, and/or increased lubrication.Type: GrantFiled: August 23, 2007Date of Patent: March 23, 2010Assignee: DePuy Products, Inc.Inventors: Richard S. King, Craig Ernsberger
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Patent number: 7666230Abstract: An implant device for cartilage regeneration in loading-bearing regions uses the osteochondral defect model. The implant is formed of resorbable polymeric materials. The implant is designed such that load is transmitted from the articulating surface of the bone platform through the implant to the entire area of subchondral bone of the bone platform. Application of load in this manner results in reduced subchondral bone resorption, leading to joint stabilization and maintenance of normal joint biomechanics. The implant allows for the incorporation therein of a resorbable scaffold or matrix material. The present implant solves the current inability to regenerate cartilage in load-bearing articulating surfaces using engineered scaffold devices.Type: GrantFiled: December 8, 2003Date of Patent: February 23, 2010Assignee: DePuy Products, Inc.Inventors: Janine M. Orban, Herbert E. Schwartz, Nathaniel W. Grobe
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Patent number: 7645504Abstract: Coatings for implantable medical devices and methods for fabricating thereof are disclosed. The coatings include a layer comprising a hydrophobic polymer and a layer comprising a hydrophilic or amphiphilic polymer.Type: GrantFiled: June 26, 2003Date of Patent: January 12, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Stephen D. Pacetti
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Patent number: 7635725Abstract: Highly crystalline, oxidation resistant crosslinked polymeric materials such as crosslinked ultrahigh molecular weight polyethylenes having high wear resistance, enhanced stiffness, enhanced tensile strength, a high level of fatigue and crack propagation resistance, and enhanced creep resistance can be manufactured by the new methods described herein.Type: GrantFiled: February 21, 2006Date of Patent: December 22, 2009Assignee: The Brigham and Women's Hospital, Inc.Inventors: Anuj Bellare, Thomas S. Thornhill
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Patent number: 7632294Abstract: Surgical methods of repairing defects and deficiencies in the spine are disclosed. The methods involve delivering a single part in-situ polymerizing fluid to (i) close a weakened segment or fissure in the annulus fibrosus, (ii) strengthen the annulus, (iii) replace or augment the disc nucleus, or (iv) localize a disc prosthesis. The methods may include placing a delivery conduit adjacent to the repair site and providing a liquid tissue adhesive to bond to and repair a disc defect or deficiency.Type: GrantFiled: June 22, 2004Date of Patent: December 15, 2009Assignee: Promethean Surgical Devices, LLCInventors: Michael T Milbodker, Jeffrey A Wilson, Robert M Arcangeli
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Patent number: 7628851Abstract: The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.Type: GrantFiled: May 30, 2008Date of Patent: December 8, 2009Assignee: Synthes USA, LLCInventors: Bryan Monro Armitage, Ira C Ison, Mark Thomas Fulmer, Sean Hamilton Kerr, Michael Lehmicke, Patrick Leamy, William Schiffer
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Patent number: 7621963Abstract: A bone graft material comprising about 50-90% quickly bioresorbable porogen particles and about 10-50% of a calcium matrix material. A bioactive substance can be included in the matrix material, the porogen particles, or both. Commercial packages containing the bone graft materials and methods for repairing bone therewith are also claimed.Type: GrantFiled: April 11, 2006Date of Patent: November 24, 2009Assignee: EBI, LLCInventors: Bruce J. Simon, Robert M. Ronk, Paul D'Antonio, Jeffrey D. Schwardt
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Patent number: 7621959Abstract: Bioprosthetic devices include an exterior biological tissue member which at least partly defines a cavity, and a proteinaceous biopolymer which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms. the bioprosthetic device is a bioprosthetic vertebral disc having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer. Preferably, the proteinaceous biopolymer is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.Type: GrantFiled: December 10, 2004Date of Patent: November 24, 2009Assignee: CryoLife, Inc.Inventors: K. Umit Yuksel, Steven P. Walsh, Kirby S. Black
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Publication number: 20090280179Abstract: A resorbable bone replacement material made of calcium phosphate particles of different phases which are embedded in an inventive-specific cross-linked collagen matrix. The goal is to form a non-brittle, bone replacement moulded body having a positive fit, i.e. having a shape which is anatomic and/or corresponds to the defect, which perfectly fills the bone defect and can be resorbed thereby. Said goal is achieved by producing the bone replacement material made of a mixture of calcium phosphate particles which is embedded in an inventive cross-linked collagen matrix. In particular, the collagen cross-linking is achieved by a Laccase-induced peptide cross-linking and suitable bridge molecules. Essentially substituted dihydroxyarmotes and/or substrates of the lignolytic polyphenoloxidases, such as Laccases, are suitable as bridge molecules.Type: ApplicationFiled: February 9, 2007Publication date: November 12, 2009Inventors: Hans-Georg Neumann, Ernst-Dieter Klinkenberg, Frieder Schauer, Ulrike Lindequist, Wolf-Dieter Juelich, Annett Mikolasch, Katrin Manda
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Patent number: 7604668Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.Type: GrantFiled: July 29, 2005Date of Patent: October 20, 2009Assignee: Gore Enterprise Holdings, Inc.Inventors: Ted R. Farnsworth, Charles Flynn, Charles F. White
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Patent number: 7563483Abstract: Methods for fabricating coatings for implantable medical devices are disclosed. The coatings include hydrophilic and hydrophobic components. The methods provide for treatment of the coatings to cause enrichment a region close to, at or on the outer surface of the coating with the hydrophilic component.Type: GrantFiled: February 22, 2005Date of Patent: July 21, 2009Assignee: Advanced Cardiovascular Systems Inc.Inventors: Syed F. A. Hossainy, Yiwen Tang, Andrew C. Tung, Stephen D. Pacetti
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Publication number: 20090164014Abstract: A biodegradable osteochondral implant comprises a porous top and a porous bottom section separated by a barrier impermeable to agents that have a detrimental effect on the regeneration of cartilage. The implant or its top section is of rotationally symmetric or parallelepipedal form and comprises a resilient polymer material such as polyurethane urea. Also disclosed is a corresponding sheet material from which implants can be excised, processes of manufacture of the implant and the sheet material, and a method for implanting the osteochondral implant in a recess prepared in a load-bearing surface of a joint.Type: ApplicationFiled: October 18, 2006Publication date: June 25, 2009Applicant: Artimplant ABInventors: Elisabeth Liljensten, Anders Persoon
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Patent number: 7537782Abstract: Resorbable polymer barrier membranes and methods of their applications are disclosed. In a broad embodiment, methods of governing bone growth, or preventing bone growth into a certain spatial area, includes the step of forming a spatial barrier with the present resorbable barrier membrane. The barrier membrane separates a bone-growth area and a non-bone-growth area, and prevents bone from growing into the non-growth area.Type: GrantFiled: February 27, 2003Date of Patent: May 26, 2009Assignee: Kensey Nash CorporationInventors: Christopher J. Calhoun, G. Bryan Cornwall
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Patent number: 7517539Abstract: The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite.Type: GrantFiled: October 16, 1997Date of Patent: April 14, 2009Assignee: Etex CorporationInventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi