Bone Surface Coating Patents (Class 623/23.6)
  • Patent number: 9511170
    Abstract: Calcium phosphate and related coating powder particles comprising a surface component comprising a silicate content, plasma sprayed coatings thereof on implantable medical/dental devices, and bone grafting materials of such coated particles. Optionally, biologically active agents such as bone morphogenetic proteins, growth factors, analgesics, and antibiotics can be incorporated therein.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: December 6, 2016
    Assignee: CaP Biomaterials, LLC
    Inventors: Lawrence A. Shimp, William G. Hubbard, Keith A. Orlowski
  • Patent number: 9468478
    Abstract: An interlocking intramedullary rod assembly for treating a fracture, the assembly including an intramedullary rod having a distal section and a proximal section; a distal interlocking screw; and a proximal interlocking screw; wherein the distal section comprises a static distal seat for receiving the distal interlocking screw, and the proximal section comprises a dynamic proximal seat for receiving the proximal interlocking screw; and further wherein the static distal seat is configured to secure the distal interlocking screw to the intramedullary rod such that the distal interlocking screw cannot move relative to the intramedullary rod, and the dynamic proximal seat is configured to secure the proximal interlocking screw to the interlocking rod such that a first end of the proximal interlocking screw cannot move relative to the intramedullary rod and the second end of the proximal interlocking screw can move relative to the intramedullary rod.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: October 18, 2016
    Inventor: Sreevathsa Boraiah
  • Patent number: 9370605
    Abstract: A method for coating an orthopedic implant made of a titanium or titanium alloy substrate with a cobalt-chrome molybdenum alloy uses multi-arc physical vapor deposition (MA-PVD). The substrate has a first bearing surface coated with a coating made of the deposited cobalt-chromium molybdenum alloy. The bearing surface slidably receives a second bearing surface of the prosthetic joint component. The MA-PVD cobalt-chromium molybdenum alloy coating forming the first bearing surface is made up of hexagonal close packed (HCP) grains having a columnar structure with a length of about 1 ?m and a width of about 0.1 ?m with the length of each HCP grains being oriented generally perpendicular to the titanium substrate bearing surface.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: June 21, 2016
    Assignee: Howmedica Osteonics Corp.
    Inventors: Zongtao Zhang, Keenan Michael Hanson, Thomas Francis McCarthy, Daniel E. Lawrynowicz, Aiguo Wang
  • Patent number: 9055977
    Abstract: The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: June 16, 2015
    Assignee: Zimmer, Inc.
    Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
  • Patent number: 9034051
    Abstract: A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: May 19, 2015
    Assignee: ADVANCED MEDIX INC.
    Inventors: Tadashi Kokubo, Takashi Kizuki, Seiji Yamaguchi, Tomiharu Matsushita
  • Patent number: 8974541
    Abstract: The invention relates to a bone implant which comprises a magnesium-containing metallic material having a reduced corrosion rate and inorganic bone cement, and to methods and a kit for producing the bone implant. With a method according to the invention, it is possible to obtain a bone implant which comprises inorganic bone cement and a magnesium-containing metallic material with a corrosion-inhibiting coating which contains magnesium-ammonium phosphates. In the method according to the invention, a magnesium-containing metallic material, of which the surface has a magnesium oxide layer and/or a magnesium salt layer, is combined with inorganic bone cement in order to generate a solid composite material that comprises the inorganic bone cement and the magnesium-containing metallic material.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: March 10, 2015
    Assignee: InnoTERE GmbH
    Inventors: Berthold Nies, Stefan Glorius
  • Patent number: 8945363
    Abstract: A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer may be grown from the metal substrate, by anodizing, and the biocidal material incorporated in it by ion exchange. Alternatively the layer may be deposited by electroplating, followed by diffusion bonding so as to become integral with the metal substrate. In either case, silver is a suitable biocidal material; and both the release rate and the quantity of biocidal material should be low to avoid toxic effects on body cells. Electropolishing the surface before formation of the surface layer is also beneficial, and this may be achieved by electropolishing.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: February 3, 2015
    Assignee: Accentus Medical Limited
    Inventors: Martin Edward Lee Pickford, Andrew Derek Turner
  • Publication number: 20140324186
    Abstract: Medical implants with non-equilibrium surface structures are disclosed. The surface treatment of the implants greatly enhances osseointegration, reduces time to recovery following implant surgery, reduces surgery-related infections, and improves outcomes. The implants, including dental implants and other implants for insertion into or attachment to bone, are applicable to treatment of a wide variety of medical conditions. The methods of altering the surface properties of medical implants include exposure of a crystalline surface material, such as metal or ceramic, to a short burst of high thermal energy or shock, resulting in the introduction of a non-equilibrium concentration of crystal lattice defects in a surface layer.
    Type: Application
    Filed: November 15, 2012
    Publication date: October 30, 2014
    Inventors: Gordon Daniel Blacklock, Vivek R. Dave
  • Patent number: 8845751
    Abstract: An endoprosthesis component and a method for producing an endoprosthesis component is disclosed. The endoprosthesis component comprises a body predefining the shape of the endoprosthesis component. On surface portions with which the endoprosthesis component in the implanted state is in contact with human tissue, the body is covered with an outer layer which comprises a nitride, an oxynitride or an oxide based on a refractory metal and which contains silver and/or copper. An intermediate layer is arranged between the outer layer and the body in such a way that parts of the intermediate layer are accessible from the outside. The endoprosthesis component enables generation of a long-term antimicrobial action with the outer layer and, in addition, action on the surrounding tissue from the intermediate layer.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: September 30, 2014
    Assignee: Waldemar Link GmbH & Co. KG
    Inventors: Helmut D. Link, Roger Thull
  • Patent number: 8815328
    Abstract: Methods are presented for a continuous, two-step, phase sequenced deposition of hydroxyapatite film over the surface of the substrate.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: August 26, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Richard E. Riman, Alexander Burukhin, Eugene Zlotnikov, Dan Haders
  • Patent number: 8679190
    Abstract: An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: March 25, 2014
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: David Myung, Lampros Kourtis, Laura Hartmann, Curtis W. Frank, Stuart B. Goodman, Dennis R. Carter
  • Patent number: 8673016
    Abstract: A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is provided by the space between the bioactive glass fiber in the porous matrix. Strength of the bioresorbable matrix is provided by bioactive glass that fuses and bonds the bioactive glass fiber into the rigid three-dimensional matrix. The resorbable tissue scaffold supports tissue in-growth to provide osteoconductivity as a resorbable tissue scaffold, used for the repair of damaged and/or diseased bone tissue.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: March 18, 2014
    Assignee: Bio2 Technologies, Inc.
    Inventor: James Jenq Liu
  • Publication number: 20140067058
    Abstract: Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.
    Type: Application
    Filed: August 14, 2013
    Publication date: March 6, 2014
    Applicant: MIMEDX GROUP, INC.
    Inventors: Thomas J. KOOB, Robert TOFE, Elizabeth CHEN
  • Patent number: 8623446
    Abstract: The invention is directed to an ion plasma deposition (IPD) method adapted to coat polymer surfaces with highly adherent antimicrobial films. A controlled ion plasma deposition (IPD) process is used to coat a metal or polymer with a selected metal/metal oxide. Exposing the coated surface to ultraviolet light significantly improves the antimicrobial properties of the deposited coatings.
    Type: Grant
    Filed: October 3, 2006
    Date of Patent: January 7, 2014
    Assignee: Metascape LLC
    Inventors: Terrence S. McGrath, Deidre Sewell, Daniel M. Storey
  • Patent number: 8524798
    Abstract: Compositions for use in treating and repairing orthopedic defects are provided. The compositions are especially useful for performing percutaneous vertebroplasty, percutaneous kyphoplasty and other procedures. When cured, the compositions are relatively solid but compressible, and prior to curing are viscous liquids with a low enough viscosity to fill voids in cavities such as voids within fractured vertebrae. Optionally, the properties of a composition according to the invention can be adjusted taking into account the hardness and density of the orthopedic structure to be repaired. Also disclosed are devices and methods for using the compositions, and a kit containing components for forming and utilizing the composition.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: September 3, 2013
    Inventors: Linda M. Trebing, Ralph W. Carmichael
  • Patent number: 8507101
    Abstract: A biocorrodible implant includes a base formed from magnesium or a biocorrodible magnesium alloy, whose surface has a corrosion-inhibiting coating. A diffusion layer, which covers the base, differs in composition from the implant material. The diffusion layer contains at least one metallic element of the implant material and at least one corrosion-inhibiting element selected from the group of Al, Zn, Ca, Si, In, Mn, Sc and RE, where RE stands for rare earth metals. The implant optionally includes a metal layer of at least one of the corrosion-inhibiting elements selected from the group of Al, Zn, Ca, Si, In, Mn, Sc and RE covering the diffusion layer, and a passivating layer of metal oxides, metal nitrides or metal fluorides of at least one of the corrosion-inhibiting elements selected from the group of Al, Zn, Ca, Si, In, Mn, Sc and RE covering the diffusion layer or the metal layer.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: August 13, 2013
    Assignee: Biotronik VI Patent AG
    Inventors: Alexander Rzany, Heinz Mueller
  • Publication number: 20130190888
    Abstract: The present invention relates to an implant having a multilayered coating comprising a porous titanium-based layer on the implant, an optional interface titania layer on and/or in the porous titanium-based layer and a bioactive glass layer on and/or in the porous structure formed by the titanium-based and titania layer(s); as well as to a process for preparing an implant having a multilayered coating.
    Type: Application
    Filed: April 13, 2011
    Publication date: July 25, 2013
    Applicant: INSTITUT "JOžEF STEFAN"
    Inventors: Sasa Novak Krmpotic, Natasa Drnovsek, Gregor Murn
  • Patent number: 8486152
    Abstract: An orthopedic implant comprising a metallic substrate coated with a diamond-like carbon (DLC) layer, and a layer of a polymeric material placed over the DLC layer that is less stiff than the substrate, and methods of manufacturing the same.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: July 16, 2013
    Assignee: DePuy Synthes Products, LLC
    Inventors: Cyril Voisard, Goetz Thorwarth, Markus Kraft
  • Publication number: 20130150978
    Abstract: The invention relates to a bone implant which comprises a magnesium-containing metallic material having a reduced corrosion rate and inorganic bone cement, and to methods and a kit for producing the bone implant. With a method according to the invention, it is possible to obtain a bone implant which comprises inorganic bone cement and a magnesium-containing metallic material with a corrosion-inhibiting coating which contains magnesium-ammonium phosphates. In the method according to the invention, a magnesium-containing metallic material, of which the surface has a magnesium oxide layer and/or a magnesium salt layer, is combined with inorganic bone cement in order to generate a solid composite material that comprises the inorganic bone cement and the magnesium-containing metallic material.
    Type: Application
    Filed: June 15, 2011
    Publication date: June 13, 2013
    Applicant: InnoTERE GMBH
    Inventors: Berthold Nies, Stefan Glorius
  • Publication number: 20130096691
    Abstract: A composition of matter comprising a water-swellable IPN or semi-IPN including a hydrophobic thermoset or thermoplastic polymer and an ionic polymer, articles made from such composition and methods of using such articles. The invention also includes a process for producing a water-swellable IPN or semi-IPN from a hydrophobic thermoset or thermoplastic polymer including the steps of placing an ionizable monomer solution in contact with a solid form of the hydrophobic thermoset or thermoplastic polymer; diffusing the ionizable monomer solution into the hydrophobic thermoset or thermoplastic polymer; and polymerizing the ionizable monomers to form a ionic polymer inside the hydrophobic thermoset or thermoplastic polymer, thereby forming the IPN or semi-IPN.
    Type: Application
    Filed: December 3, 2012
    Publication date: April 18, 2013
    Applicants: Emergence Venture Partners, LLC, Biomimedica, Inc.
    Inventors: Biomimedica, Inc., Emergence Venture Partners, LLC
  • Patent number: 8414654
    Abstract: An implant device for humans or mammals has a body structure having an exposed surface and one or more selected portions of the exposed surface having a bone formation enhancing 3-dimensional pattern. The exposed surface can be on exterior portions of the body structure or internal portions of the body structure or both. The one or more selected portions of the exposed portions having the bone formation enhancing 3-dimensional patterns are in the external exposed surfaces or in the internal exposed surfaces or both internal and external exposed surfaces.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: April 9, 2013
    Assignee: Amendia, Inc.
    Inventor: Timothy Ganey
  • Publication number: 20130030544
    Abstract: An implant is provided with a main body (1) and with a double coating applied to at least one surface section of the main body (1), wherein the double coating comprises an adhesion promoter layer (2), applied directly to the at least one surface section of the main body, and of an osteointegrative layer (3) covering the adhesion promoter layer (2). The layers (2;3) consist of pure titanium, wherein the adhesion promoter layer (2) has a thickness of 2-6 ?m, in particular a thickness of 3-5 ?m, and the osteointegrative layer (3) has a thickness of 50-70 ?m, in particular of 55-65 ?m. Moreover, the osteointegrative layer (3) has a porosity of 70-90% and a roughness Rzof at least 45 ?m. A related method is also provided for producing such an implant.
    Type: Application
    Filed: April 12, 2011
    Publication date: January 31, 2013
    Applicant: ADVANCED MEDICAL TECHNOLOGIES AG
    Inventor: Armin Studer
  • Publication number: 20120271431
    Abstract: The invention relates to methods for producing a partial or complete bioactive coating of an iron and/or zinc based metal implant material with calcium phosphates, a bioactively coated iron and/or zinc based metal implant, which is partially or completely coated with calcium phosphates, and bone implants containing an implant material according to the invention. In order to produce the coating according to the invention, iron and/or zinc based metal implant materials are brought in contact with acidic aqueous solutions, which have a pH value of 6.0 or less and contain calcium phosphates, whereby a calcium phosphate layer is deposited on the surface of the implant materials. The iron and/or zinc based metal implant materials, which are used in methods according to the invention, are materials consisting of base iron alloys or pure iron or materials that contain other substances, which are coated with pure iron, with a base iron alloy and/or with zinc.
    Type: Application
    Filed: September 3, 2010
    Publication date: October 25, 2012
    Applicant: INNOTERE GMBH
    Inventors: Berthold Nies, Stefan Glorius, Sophie Rössler
  • Publication number: 20120172997
    Abstract: A bone implant includes (a) a first layer provided over a first outer surface of the bone implant and being formed of a first material which is one of water-soluble and degradable in body fluids, the first layer having a first thickness and (b) a second layer provided over an outer periphery of the first layer and being formed of a biocompatible material, the second layer having a second thickness smaller than the first thickness.
    Type: Application
    Filed: July 6, 2011
    Publication date: July 5, 2012
    Inventors: Goetz THORWARTH, Cyril VOISARD
  • Patent number: 8187660
    Abstract: A method of fabricating a medical implant component. The method may include the steps of producing a substrate from a first material wherein the substrate has a bearing portion, spraying particles of a second material onto the bearing portion in accordance with a predetermined spraying technique to provide a coating thereon, and subjecting the coated bearing portion to a hot isostatic pressing process, a vacuum sintering process, or a controlled atmospheric sintering process. The first material may be the same as or different from the second material. The predetermined spraying technique may be a thermal type spraying process such as a plasma spraying process or a high velocity oxygen fuel spraying process.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: May 29, 2012
    Assignee: Howmedica Osteonics Corp.
    Inventors: Daniel E. Lawrynowicz, Aiguo Wang
  • Publication number: 20120101589
    Abstract: The present invention relates to methods of coating prosthetic devices with dried fibrin. Particularly, the present invention relates to methods of coating the surface of prosthetic devices with fibrin and drying the fibrin-coated prosthetic devices at moderately-high temperatures for extended periods of time under low atmospheric pressure to obtain prosthetic devices coated with stable cross-linked fibrin capable of binding cells and thereby capable of integrating into tissues.
    Type: Application
    Filed: May 12, 2010
    Publication date: April 26, 2012
    Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventor: Raphael Gorodetsky
  • Publication number: 20120083898
    Abstract: In a prosthesis component of a joint endoprosthesis, the prosthesis component comprises a sliding surface that is designed to form a sliding joint with a counter sliding surface of another prosthesis component. The sliding surface may be formed by a sliding surface coating deposited on the body of the prosthesis component, wherein the sliding surface coating has an antimicrobial effect. The sliding surface coating is active against microorganisms in the area of the sliding joint.
    Type: Application
    Filed: October 5, 2011
    Publication date: April 5, 2012
    Applicant: DERU GMBH
    Inventors: Roger Thull, Ulrike Thull
  • Publication number: 20120071986
    Abstract: The invention relates to an implant for the human or animal body, which on its outer surface comprises at least one calcium salt that is soluble in a polar liquid. The invention also refers to various methods for the preparation of the preceding implant. The calcium ions contained on the surface of the implant provide said surface with four chemically and biologically advantageous properties: hydrophilicity, protection against atmospheric contamination, a pro-coagulant property and a pro-mineralising property.
    Type: Application
    Filed: September 15, 2011
    Publication date: March 22, 2012
    Applicant: BIOTECHNOLOGY INSTITUTE, I MAS D, S.L.
    Inventors: Eduardo ANITUA ALDECOA, Ricardo TEJERO CANTERO
  • Patent number: 8100983
    Abstract: Generally, an intra-osseous fusion system which provides an implantable intra-osseous member and a method of implanting the intra-osseous member for bone on growth which retains an amount of digit curvature.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: January 24, 2012
    Inventor: Robert C. Schulte
  • Publication number: 20110307068
    Abstract: A coating for a CoCrMo substrate including a first layer located directly on the substrate and including Ta(CoCrMo)0.5-2.0, a second layer located directly on the first layer and including tantalum, a third layer located directly on the second layer and including tantalum carbide, and a fourth layer located directly on the third layer and including diamond-like carbon (DLC).
    Type: Application
    Filed: April 14, 2011
    Publication date: December 15, 2011
    Applicant: Synthes USA, LLC
    Inventors: Roland Hauert, Goetz Thorwarth, Claudiu Falub, Ulrich Mueller, Cyril Voisard
  • Publication number: 20110230973
    Abstract: Methods for bonding a porous tantalum structure to a substrate are provided. The method includes placing a compressible or porous interlayer between a porous tantalum structure and a cobalt or cobalt-chromium substrate to form an assembly. The interlayer comprising a metal or metal alloy that has solid state solubility with both the substrate and the porous tantalum structure. Heat and pressure are applied to the assembly to achieve solid state diffusion between the substrate and the interlayer and the between the porous tantalum structure and the interlayer.
    Type: Application
    Filed: April 22, 2011
    Publication date: September 22, 2011
    Applicant: ZIMMER, INC.
    Inventors: Gregory M. Hippensteel, Lawrence F. Peek, Jeffrey P. Anderson, Devendra Gorhe, Steve M. Allen, Clarence M. Panchison, David M. Miller, Joel G. Scrafton, Casey Harmon
  • Publication number: 20110218643
    Abstract: A method for the plasma electrolytic oxidation of a bioactive coating onto implant (4) is provided. The implant is placed in an electrolyte solution (3) providing Ca and P ions and then connected to a power supply (1). A counter electrode is also provided in the electrolyte solution. A sequence of voltage pulses having alternating polarity are then applied across the implant and counter electrode to deposit a bioactive coating onto the implant. A intra-bone implant formed by the method is also provided having a coating with a thickness of 10 to 30 microns, a porosity comprised by pores with sizes of 0.5 to 10 microns, and comprising 10 to 30 wt % of hydroxyapatites.
    Type: Application
    Filed: October 10, 2008
    Publication date: September 8, 2011
    Inventor: Aleksey Yerokhin
  • Publication number: 20110184528
    Abstract: An implant for use on a joint-facing end of a bone includes a cap having convex outer surface overlying a concave inner surface and a stem protruding from the inner surface such that an edge of the cap surrounds the stem and overhangs a portion of the stem leading up to the inner surface. The stem may further include a plurality of raised ridges parallel to its length that begin near a tip of the stem and extend onto the portion of the stem overhung by the edge.
    Type: Application
    Filed: January 22, 2010
    Publication date: July 28, 2011
    Applicant: OsteoMed L.P.
    Inventors: Brandon G. Beckendorf, Geronimo Hernandez
  • Publication number: 20110144761
    Abstract: One embodiment of the invention relates to a biocorrodible implant based on magnesium or a biocorrodible magnesium alloy, whose surface has a corrosion-inhibiting coating. Furthermore, other invention embodiments relate to a respective manufacturing method for the coating.
    Type: Application
    Filed: October 29, 2010
    Publication date: June 16, 2011
    Inventors: Alexander Rzany, Heinz Mueller
  • Publication number: 20110135704
    Abstract: Apparatus and methods for disrupting the colonization of Staphylococcus aureus are disclosed. A lysostaphin antimicrobial coating for bone implants and a lysostaphin gel for use on open wounds to reduce infections are disclosed.
    Type: Application
    Filed: April 21, 2010
    Publication date: June 9, 2011
    Inventor: John I. Shipp
  • Publication number: 20110112654
    Abstract: One arrangement in combination, a bone implant, and one or more bioactive substances which can reduce inflammation in implant surgery, preferably in the field of dentistry. The implant may also comprise one or more bioactive substance(s) that can promote osseointegration of said bone implant. At least one of said one or more bioactive substances may be capable of reducing proliferation, differentiation, and/or activity of osteoclasts, stimulating proliferation of osteoblasts, and/or reducing inflammation.
    Type: Application
    Filed: July 13, 2009
    Publication date: May 12, 2011
    Applicant: NOBEL BIOCARE SERVICES AG
    Inventor: Jenny Faldt
  • Publication number: 20110106243
    Abstract: The invention relates to a method for coating medical devices with a biocompatible protein coating.
    Type: Application
    Filed: June 25, 2009
    Publication date: May 5, 2011
    Inventors: Elisabeth Marianna Wilhelmina Maria Van Dongen, Sebastianus Gerardus Kluijtmans, Jan Bastiaan Bouwstra
  • Publication number: 20110077746
    Abstract: Methods for cleaning and limiting the extent of adhesives are disclosed. For example, a method for cleaning adhesive near a surgical site in a patient's body comprises the acts of dispensing a magnetic adhesive at a desired location at the surgical site, and applying an external magnetic field that removes a portion of the magnetic adhesive from the body of the patient outside of the desired location.
    Type: Application
    Filed: September 29, 2009
    Publication date: March 31, 2011
    Applicant: JOSHUA CHARLES HARRISON
    Inventor: Albert Thomas Harrison
  • Publication number: 20110054630
    Abstract: An artificial bone comprising a support coated with an apatite/collagen composite, and a method for producing the artificial bone by immersing the support in a dispersion of the fibrous apatite/collagen composite and drying it.
    Type: Application
    Filed: April 24, 2009
    Publication date: March 3, 2011
    Applicant: HOYA CORPORATION
    Inventor: Daisuke Shoji
  • Publication number: 20110054629
    Abstract: The present invention provides a composite implant comprising pores of a porous structure filled with a biodegradable magnesium-based alloy. Further, the present invention provides a composite implant which filles pores of the porous structure prepared by a metal, a ceramic or a polymer with a biodegradable magnesium-based alloy. Mechanical properties of the composite implant of the present invention are improved because a magnesium-based alloy filled in its pores increases the strength of a porous structure comprised of a metal, a ceramic or a polymer. Further, it can be expected that the magnesium-based alloy filled in the porous structure is decomposed in a living body, thus increasing bone formation rate. Accordingly bone tissue can be rapidly formed because the composite implant of the present invention has high strength and excellent interfacial force between the composite implant and bone tissue, compared to conventional porous materials.
    Type: Application
    Filed: March 18, 2009
    Publication date: March 3, 2011
    Applicant: U&I CORPORATION
    Inventors: Hyun-Kwang Seok, Seok-Jo Yang, Yu-Chan Kim, Ja-Kyo Koo
  • Publication number: 20110046747
    Abstract: This invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.
    Type: Application
    Filed: February 16, 2010
    Publication date: February 24, 2011
    Inventors: Kelvin Wai Kwok Yeung, Kenneth Man Chee Cheung, Keith Dip Kei Luk, Che Yan Yeung, Richard Yi Tsun Kao, Paul Kim Ho Chu
  • Publication number: 20110022178
    Abstract: A medical device having body contacting surfaces provided with a film of amorphous calcium phosphate having a thickness of 1 nm to 10000 nm and an average dissolution rate calculated as the time taken to remove 95% of the film of at least 1 nm h?1 as determined in accordance with ASTM Standard P1926-03. The characteristics of the film are such that the film is relatively rapidly dissolved from the surface by body fluids. This dissolution of the surface film of amorphous calcium phosphate is sufficiently fast to prevent the attachment of bacteria, thus preventing them forming a biofilm and keeping the cells in a planktonic (non-biofilm) state where they are more vulnerable to the body's defences. The invention is particularly applicable to implants (e.g. orthopaedic implants such as prosthetic hips) but may also be applied to “non-implanted” devices such as surgical instruments.
    Type: Application
    Filed: September 27, 2010
    Publication date: January 27, 2011
    Inventors: David Malcolm Grant, Nicholas William Botterill
  • Publication number: 20100286790
    Abstract: The invention relates to an implant made of biocompatible materials, in particular a prosthesis implanted without cement for traumatology and/or orthopedics, which has a main body with an anchoring region which anchors in bone or tissue, with the anchoring region being provided at least partially with a covering layer, the covering layer being formed from a powder using a thermal spraying method, in particular a plasma spraying method. The powder consists essentially of calcium phosphate and comprises antibacterially effective active constituents.
    Type: Application
    Filed: May 12, 2010
    Publication date: November 11, 2010
    Applicant: Medicoat AG
    Inventors: Heiko GRUNER, Philipp Gruner, Francis Tourenne
  • Publication number: 20100262258
    Abstract: The present invention provides a process for the preparation of a silicate and carbonate co-substituted calcium phosphate material. The process comprises the steps of: forming a silicon and optionally carbon-containing calcium phosphate precipitate by an aqueous precipitation method involving preparing an aqueous solution comprising phosphate ions, silicate ions, calcium ions and optionally carbonate ions, wherein the ratio of Ca/P and of Ca/(P+Si) in the solution is maintained above approximately 1.67; and heating the precipitate in an atmosphere comprising carbon and oxygen to form a silicate and carbonate co-substituted calcium phosphate material. The present invention also provides a synthetic carbonate and silicate co-substituted hydroxyapatite material, as well as a biomedical material.
    Type: Application
    Filed: April 11, 2008
    Publication date: October 14, 2010
    Applicants: UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN, APATECH LIMITED
    Inventors: Iain R. Gibson, Janet M. S. Skakle, Daniel J. Hadden, Thomas Buckland
  • Patent number: 7812098
    Abstract: Disclosed is a bearing material of a medical implant comprising a polymer such as UHMWPE and a surface active agent that is not covalently bonded to the polymer. The bearing material has a reduced wear rate. Also disclosed is a method of reducing the wear rate of a polymeric bearing material of a medical implant when it articulates against a hard counterface in the presence of synovial fluid, the method comprising providing a surface active agent in the synovial fluid in close proximity to the bearing surface, the hard counterface, or both.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: October 12, 2010
    Assignee: Depuy Products, Inc.
    Inventors: Craig Ernsberger, Yen-Shuo Liao, Lawrence Salvati
  • Publication number: 20100256758
    Abstract: A monolithic orthopedic implant including a porous region having a form of interconnected porosity similar to cancellous bone to promote skeletal fixation by bone ingrowth, a transition region adjacent to and integrally joined to the porous region, the transition region having a form of interconnected porosity similar to subchondral bone, a substantially dense region integrally joined to the transition region and having a perimeter, and a surface on the substantially dense region, the surface having a finish adapted for articulation against native articular cartilage.
    Type: Application
    Filed: April 2, 2009
    Publication date: October 7, 2010
    Applicant: SYNVASIVE TECHNOLOGY, INC.
    Inventors: Jeffrey D. GORDON, Michael G. Fisher, Paul R. Johnson, Kenneth D. Johannaber
  • Publication number: 20100255447
    Abstract: Disclosed herein are methodologies and compositions for coating materials, which can be used in a variety of biological applications.
    Type: Application
    Filed: October 23, 2009
    Publication date: October 7, 2010
    Inventors: ALEXANDRU S. BIRIS, PEDER JENSEN, GANESH KANNARPADY
  • Publication number: 20100204802
    Abstract: The present invention provides an implant (10) comprising: an antimicrobial means (11); an activation means (4) for activating the antimicrobial means (11); and a power source (4) for powering the activation means. The present invention also provides a system comprising such an implant interfaced with a separate control means.
    Type: Application
    Filed: September 21, 2007
    Publication date: August 12, 2010
    Inventors: Darren ... Wilson, Robert Morgan
  • Patent number: 7771773
    Abstract: The present invention provides orthopedic prosthesis having at least one metallic component that includes a metallic substrate on which an integrally formed nano-crystalline coating is formed. The coating and the substrate have at least one metallic constituent in common having an average atomic concentration in the coating that differs from an average atomic concentration in the substrate by less than about 10 percent. Further, the nano-crystalline coatings includes crystalline grains with an average size in a range of about 1 to 999 nanometers, and more preferably in a range of about 10 to 200 nanometers. A transition region that exhibits a graded reduction in average grain size separates the coating from the substrate. The coating advantageously exhibits an enhanced hardness, and a high degree of resistance to corrosion and wear. In one application, the nano-crystalline coatings of the invention are utilized to form articulating surfaces of various orthopedic devices.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: August 10, 2010
    Assignee: Spire Corporation
    Inventor: Fereydoon Namavar
  • Patent number: 7771774
    Abstract: A method of forming an implant to be implanted into living bone is disclosed. The method comprises the act of roughening at least a portion of the implant surface to produce a roughened surface. The method further comprises the act of depositing discrete nanoparticles on the roughened surface though a one-step process of exposing the roughened surface to a solution. The nanoparticles comprise a material having a property that promotes osseointegration.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: August 10, 2010
    Assignee: Biomet 3l, LLC
    Inventors: Bruce Berckmans, III, Ross W. Towse, Robert L. Mayfield