Bone Composition Patents (Class 623/23.61)
  • Patent number: 10889789
    Abstract: A perfusion bioreactor chamber for engineering a broad spectrum of tissues. The bioreactor allows controlled distribution of fluid through or around scaffolding materials of various shapes, structures and topologies during prolonged periods of cultivation.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: January 12, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Gordana Vunjak-Novakovic, Sarindr Bhumiratana, Keith Yeager
  • Patent number: 10743982
    Abstract: An implantable biodegradable medical device arranged for breast reconstruction and/or augmentation, made of an interconnected porous structured polymeric matrix and belonging to the family of poly(urea urethane)s. The porous structured polymeric matrix of the medical device comprises a plurality of three dimensional channels, drilled by means of heated tools, three-dimensionally propagating through the polymeric matrix ad interconnected with the porous structure of the polymeric matrix. The polymeric matrix comprises high to-medium molecular weight hydrophobic biodegradable amorphous soft segments polyols, having average molecular weight comprised between 20?000 and 60?000 Da,—hydrophilic polyalkoxide polyols, of average molecular weight comprised between 2?000 and 15?000 Da, and low molecular weight polyisocyanates and polyols, whose average molecular weights range between 15 and 200 Da.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: August 18, 2020
    Assignee: TENSIVE SRL
    Inventors: Irini Gerges, Federico Martello, Margherita Tamplenizza, Alessandro Tocchio
  • Patent number: 10736717
    Abstract: A dental implant with a post element is inserted into a jawbone with a mounting element attached to the post element, with the post element designed as a ceramic body of yttrium- and/or aluminum oxide stabilized zirconium oxide. The dental implant has improved ingrowth during osseous implant healing. The surface of the dental implant is provided with at least one partial area that has nanoscopic pores or an otherwise executed nanoscopic structure that has a depletion zone with a reduced yttrium- and/or aluminum oxide element.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: August 11, 2020
    Inventor: Holger Zipprich
  • Patent number: 10729548
    Abstract: A bioactive filamentary structure includes a sheath coated with a mixture of synthetic bone graft particles and a polymer solution forming a scaffold structure. In forming such a structure, synthetic bone graft particles and a polymer solution are applied around a filamentary structure. A polymer is precipitated from the polymer solution such that the synthetic bone graft particles and the polymer coat the filamentary structure and the polymer is adhered to the synthetic bone graft particles to retain the graft particles.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: August 4, 2020
    Assignee: Howmedica Osteonics Corp.
    Inventors: Sonny Sheth, David Arazawa, J. Brook Burley, Sarah Elizabeth Smith, Matthew B. Havener, James San Antonio
  • Patent number: 10035308
    Abstract: A method of manufacturing a bone substitute structure for reconstruction of bone material in a patient. The method comprises the steps of providing data reflecting a cavity in a bone of a patient, defining and modelling a three dimensional structure corresponding to the cavity in the bone; and providing an individualized bone substitute structure, corresponding to the defined and modeled three dimensional structure, by combining calcium phosphate cement, growth factors and the patient's own un-coagulated blood.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: July 31, 2018
    Assignee: Nobel Biocare Services AG
    Inventor: Günter Uhr
  • Patent number: 9943626
    Abstract: A granule form e d from a tubular body having an outer surface and an inner surface separated by a matrix, and at least one core defining an opening extending through the tubular body. The outer surface of the matrix is adapted to permit fluid flow into and out of the matrix.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: April 17, 2018
    Inventor: Daniel S. Oh
  • Patent number: 9925306
    Abstract: The present invention relates to a carrier for growth factor related to regeneration of bone tissues that is capable of arbitrarily controlling the delivery rate of growth factors related to bone regeneration and thus especially applicable to a bone void filler in the fields of the dental or orthopedic applications. The carrier for controlling the delivery rate of the growth factor in the present invention is composed of a hyaluronic acid hydrogel having a distribution of interconnected pores and a calcium phosphate microsphere being distributed in the pores of the hyaluronic acid hydrogel. The calcium phosphate microsphere having a porosity suitable for delivery of the growth factor is positioned into the pores of the cross-linked hyaluronic acid hydrogel to complete the carrier.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: March 27, 2018
    Assignee: Bioalpha Inc.
    Inventors: Jung Ju Kim, Su Hyun Jung, Hyun Seung Ryu, Jun Hyuk Seo
  • Patent number: 9907884
    Abstract: The invention relates to a biologically degradable composite material and to a process for the preparation thereof. The biologically degradable composite material according to the invention is preferably a bone reconstruction material which can be used in the field of regenerative medicine, especially as a temporary bone defect filler for bone regeneration.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: March 6, 2018
    Assignee: CURASAN AG
    Inventors: Fabian Peters, Wolf-Dietrich Huebner, Christiane Hoffmann, Nikica Andic, Kathleen Hasanovic, Tilo Hniopek
  • Patent number: 9889227
    Abstract: A bone implant for implantation into bone tissue includes a metallic material having a surface that is covered by an oxide layer wherein the oxide layer has a thickness within the range of from 2 to 100 nm and includes strontium ions homogenously dispersed in the oxide layer. The oxide layer is a metal oxide layer formed from the metallic surface of the implant. The local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in the bone tissue.
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: February 13, 2018
    Assignee: ASTRA TECH AB
    Inventors: Christina Gretzer, Ingela Petersson
  • Patent number: 9643281
    Abstract: A process of forming a metal part from a metal powder using a laser to melt the metal powder, where a complex part can be formed in which a support structure is formed from lightly bonding metal powder together without melting so that a support structure can be formed, or melting metal powder to form thin ligaments capable of forming a support layer within the metal powder that can be easily broken away when the metal part is finished. The lightly bonded support layer of metal powder can be formed using a ceramic slurry or controlling the laser power or speed so that the metal powder is not melted but lightly bonded together.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: May 9, 2017
    Assignee: Florida Turbine Technologies, Inc.
    Inventors: Robert L Memmen, Alex Pinera
  • Patent number: 9364584
    Abstract: The present invention provides a cancellous bone scaffold to use in the replacement or repair of connective tissue such as ligaments and tendons. The cancellous bone scaffold has a fully demineralized segment with at least one adjacent mineralized end segment.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: June 14, 2016
    Assignee: Purdue Research Foundation
    Inventors: Eric A. Nauman, Darryl A. Dickerson
  • Patent number: 9326948
    Abstract: The present invention relates to a bone substitute comprising a core based on hydroxyapatite (HA), obtained from at least one porous wood, or based on collagen fibers and hydroxyapatite, and a shell, based on hydroxyapatite (HA) or silicon carbide (SiC), obtained from at least one wood having a lower porosity than the at least one wood of the core. The porous wood has a total porosity of between 60% and 95%, preferably between 65% and 85%, and it is selected from amongst the choices of rattan, pine, abachi and balsa wood. The wood of the shell has a porosity of between 20% and 60%, preferably between 30% and 50%. The bone substitute is utilized for the substitution and regeneration of bone, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, metatarsus, femur, humerus or radius.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: May 3, 2016
    Inventors: Anna Tampieri, Simone Sprio, Andrea Ruffini, Julia Will, Peter Greil, Frank Muller, Julian Martinez Fernandez, Carmen Torres Raya, Francisco Manuel Varela Feria, Joaquin Ramirez Rico, Marie-Francoise Harmand
  • Patent number: 9168139
    Abstract: A method of facilitating augmentation of osseous tissue on a surface of a bone is disclosed. The method includes combining a scaffolding, an enclosure substantially enclosing the scaffolding relatively to the surface of the bone and a cell culture seeded onto the scaffolding.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: October 27, 2015
    Assignee: Health Corporation—Rambam
    Inventors: Hadar Zigdon-Giladi, Dina Lewinson, Tova Bick, Eli Machtei
  • Patent number: 9066995
    Abstract: The invention relates to: —a porous biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material comprising a sintered CAP core and at least one uniform and closed epitactically grown layer of nanocrystalline HAP deposited on top of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, i.e.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: June 30, 2015
    Inventor: Michael Alexander Bufler
  • Publication number: 20150148911
    Abstract: To manufacture the implant a nanopowder of synthetic hydroxyapatite (Hap) is used having a hexagonal structure, average grain size in a range from 3 to 30 nm and the specific surface area greater than 200 m2/g. First the nanopowder is formed to the desired geometric shape, and then the shape is fixed. In the step of shape information the dried nanopowder is pressed in the mold under the pressure ranging from 50 Mpa to 2 GPa. In the step of fixing the pressed nanopowder at room temperature is subjected to the pressure rising from the ambient value to the peak value selected from a range of 1 to 8 GPa and to a temperature selected from a range of 100° C. to 600° C. for a period of time selected from a range from 30 seconds to 5 minutes. The density of thus produced implant, determined by helium method, is not less than 75% of the theoretical density.
    Type: Application
    Filed: June 27, 2013
    Publication date: May 28, 2015
    Inventors: Witold Lojkowski, Tadeusz Chudoba, Elzbieta Pietrzykowska, Aleksandra Kedzierska, Dariusz Smolen, Wojciech Swieszkowski, Krzysztof Kurzydlowski
  • Patent number: 9039782
    Abstract: The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: May 26, 2015
    Assignee: Wake Forest University Health Sciences
    Inventors: Anthony Atala, James J. Yoo, Grace Lim, Sang Jin Lee
  • Patent number: 9017417
    Abstract: This invention includes a subchondral bone repair system, comprising a structural component and a fluid settable component and an optional non-core component. The fluid settable component may penetrate into any pores of the structural component, and set to a solid, thereby fixing the structural component in place. The fluid settable component will penetrate interporously into the pores of the subchondral bone tissue surrounding the device, beneficially displacing any fluid to reduce edema in the affected bone region. Furthermore, the settable component, once solid is osteoconductive to promote repair and regrowth of bone in the affected region, and will also transmit mechanical force stimuli (such as compressive forces) directed through the structural component, into the adjacent bone tissue, thereby providing appropriate force stimuli necessary for appropriate tissue growth.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: April 28, 2015
    Assignee: Kensey Nash BVF Technology LLC
    Inventors: Gino Bradica, Timothy A. Ringeisen
  • Patent number: 8999001
    Abstract: A biocompatible implant for bone repair comprising a flexible membrane fitted around a bone defect and a platelet-rich plasma gel composition contained within the void space created by the membrane, its application and kit of parts thereof are described.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: April 7, 2015
    Assignee: AO Technology AG
    Inventors: Mauro Alini, Sophie Verrier, David Olivier Eglin
  • Publication number: 20150081034
    Abstract: Systems, methods and compositions useful for treatment of traumatic bone injuries are provided. In one embodiment, a bone reconstruction system comprising a space maintaining composition comprising porous polymethylmethacrylate; and an osseous generating construct comprising a polymethylmethacrylate chamber that comprises one or more osseous generating materials is provided. Associated compositions and methods are also provided.
    Type: Application
    Filed: September 19, 2014
    Publication date: March 19, 2015
    Inventors: Antonios G. Mikos, Mark E. Wong, Simon W. Young, James D. Kretlow, Meng Shi, F. Kurtis Kasper, Patrick Spicer
  • Publication number: 20150045906
    Abstract: Disclosed herein are improved surgical techniques for repairing bone defects in a sternum during a sternotomy procedure and implants adapted for such techniques. In an exemplary embodiment, provided is a fusion strip made of an osteoconductive material and of a dimension that is especially adapted for improved repair of sternal bone defects.
    Type: Application
    Filed: August 6, 2014
    Publication date: February 12, 2015
    Inventor: Mark Schumacher
  • Publication number: 20150018965
    Abstract: Provided is a bioimplant which is capable to inhibit the biofilm formation over a long period of time after an operation. The bioimplant of the present invention comprises a base material of metal, ceramic, or plastic and a thermal spraying film of a calcium phosphate-based material formed at least partially thereon and the silver concentration in the thermal-spray film is 0.05 wt % to 3.00 wt %.
    Type: Application
    Filed: January 16, 2013
    Publication date: January 15, 2015
    Inventors: Masaaki Mawatari, Masatsugu Tsukamoto, Iwao Noda
  • Patent number: 8926699
    Abstract: A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged in a core/outer layer structure.
    Type: Grant
    Filed: January 28, 2012
    Date of Patent: January 6, 2015
    Assignee: SpineSmith Partners, LP
    Inventor: Brian Burkinshaw
  • Patent number: 8916228
    Abstract: Biomedical scaffolds are described that may be used, for example, for the treatment of bone diseases and bone reconstruction and restoration. The described scaffolds having ingress and habitiaion property for cells and growth factors with serum by capillary action via engineered micro-channles. Also, the scaffolds permit nutrient and ion flow such that bone regeneration in the area surrounding the scaffold is promoted. Kits that include such scaffolds and methods of preparing and using such scaffolds are also provided.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: December 23, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Daniel Sunho Oh, Anson Ong
  • Publication number: 20140371869
    Abstract: The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
    Type: Application
    Filed: April 18, 2014
    Publication date: December 18, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: Anthony Atala, James J. Yoo, Grace Lim, Sang Jin Lee
  • Patent number: 8912247
    Abstract: Improved methods for preparing polyethylene glycol fumarate) are disclosed. Methods for chemically crosslinking or photocross-linking hydrophilic polyethylene glycol fumarate) with hydrophobic polymers such as poly(propylene fumarate) (PPF) and poly(caprolactone fumarate) (PCLF) to form various hydrogels (FIG. 1) with controllable hydrophilicity are also disclosed. The hydrogels are useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction. An injectable material including the hydrogels may be useful in controlled drug release.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: December 16, 2014
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Shanfeng Wang, Lichun Lu, Michael J. Yaszemski
  • Patent number: 8876911
    Abstract: An apparatus for the delivery of a biological composite and a method, kit, and system for preparing a biological composite is described herein. The biological composite includes both inorganic and biological materials.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: November 4, 2014
    Assignee: Orthovita, Inc.
    Inventors: James P. Murphy, Charanpreet S. Bagga, Robert J. Chiasera, Jr., Erik M. Erbe, Jeffrey G. Marx
  • Publication number: 20140288662
    Abstract: The present invention comprises devices, systems, and methods for elongating bone using an extension implant having a first end and a second end. The first end of the extension implant is inserted into an opening in the live bone and the second end of the extension implant is combined with an enlarged implant. A plurality of channels extend through the components to serve as conduits for delivering fluids and physiological signals which induce bone formation. Some embodiments include a subcutaneous cage assembly for helping to support the implant as the bone heals around it.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 25, 2014
    Applicant: Osteoceramics, Inc.
    Inventor: Thomas D. McGee
  • Publication number: 20140257514
    Abstract: A bone graft substitute in the form of an implantable three-dimensional scaffold that includes calcium phosphate and has pores. The scaffold is impregnated with a calcium and/or phosphate containing substance, and the dissolution rate DRS of the scaffold is slower than the dissolution rate DRD of the calcium and/or phosphate containing substance.
    Type: Application
    Filed: May 21, 2014
    Publication date: September 11, 2014
    Applicant: Mathys AG Bettlach
    Inventors: Marc Bohner, Reto Luginbühl
  • Patent number: 8815973
    Abstract: Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH—) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: August 26, 2014
    Assignee: Pioneer Surgical Technology, Inc.
    Inventors: Juchui Ray Lin, Edward S. Ahn, Brian M. Schlossberg
  • Publication number: 20140236312
    Abstract: Described is an artificial bone scaffold with an architecture resembling cortical bone, including microchannel-like structures resembling osteons. The scaffold enhances the ability of osteoblasts to secrete organized collagen and mineralize extracellular matrix within the osteon-like channels, thus promoting scaffold strength.
    Type: Application
    Filed: May 10, 2012
    Publication date: August 21, 2014
    Inventors: Mark R. Appleford, Marcello Pilia
  • Publication number: 20140195004
    Abstract: The present invention relates to mosaic implant (15) comprising a plurality of mosaic plates (17) connected by a wire or mesh anchoring arrangement (9). Methods for forming such implants and methods for using said implants for correction of bone and soft tissue defects are described.
    Type: Application
    Filed: March 10, 2011
    Publication date: July 10, 2014
    Inventors: Håkan Engqvist, Thomas Engstrand, Jonas Aberg, Jan Bohlin
  • Patent number: 8771748
    Abstract: Methods are provided for producing compositions, e.g. pastes or clays, which rapidly set into high-strength calcium phosphate products. In the subject methods, dry reactants that include calcium and phosphate sources, as well as a monovalent cation dihydrogen phosphate salt, are combined with a setting fluid and the combined reactants are mixed to produce the settable composition. A feature of the invention is that cements rapidly set into high strength product compositions. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: July 8, 2014
    Assignee: Skeletal Kinetics, LLC
    Inventors: Brent R. Constantz, David Delaney, Duran Yetkinler
  • Patent number: 8734525
    Abstract: An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: May 27, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Keyvan Behnam, Nanette Forsyth, James Russell, John Winterbottom, Todd Boyce
  • Patent number: 8734524
    Abstract: The invention relates to: —a biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material comprising a sintered CAP core and at least one uniform and closed epitactically grown layer of nanocrystalline HAP deposited on top of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, i.e. a length of 30 to 46 nm and a width of 14 to 22 nm, —a process of preparing the above CAP/HAP bone substitute material comprising the steps of a) preparing a sintered CAP core material, b) immersing the sintered CAP core material in an aqueous solution at a temperature between 10° C. and 50° C.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: May 27, 2014
    Assignee: Geistlich Pharma AG
    Inventor: Michael Alexander Bufler
  • Publication number: 20140142717
    Abstract: The object of the present invention is to provide a calcium phosphate-collagen fiber composite which has an excellent mechanical property, can induce bone replacement by rapid bone remodeling, and can be used in a high-load region. The object can be solved by a porous composite comprising a calcium phosphate crystal and a collagen fiber at a weight ratio of 80:20 to 20:80, wherein (1) a bioabsorbability of the porous composite is graded, and (2) the density of the porous composite determined by gravimetric method is 300 to 1500 mg/cm3.
    Type: Application
    Filed: July 4, 2012
    Publication date: May 22, 2014
    Inventors: Junzo Tanaka, Toshiyuki Ikoma, Tomohiko Yoshioka, Takashi Yoshida
  • Patent number: 8702809
    Abstract: The present invention provides a cancellous bone scaffold to use in the replacement or repair of connective tissue such as ligaments and tendons. The cancellous bone scaffold has a fully demineralized segment with at least one adjacent mineralized end segment.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: April 22, 2014
    Assignee: Purdue Research Foundation
    Inventors: Eric A. Nauman, Darryl A. Dickerson
  • Patent number: 8702808
    Abstract: Bioresorbable scaffolds for bone engineering, such as repair of bone defects, particularly long bone defects, or augmentation of bone length are described. Scaffolds are porous and comprise multiple side channels. In one embodiment, scaffolds are made from layers of micro-filament meshes comprising polycaprolactone (PCL) or a PCL-composite sequentially laid in incremental 60 degrees of rotation to produce a 0/60/120 degree layering pattern, providing for the formation of interconnected pores. The scaffold can comprise a central channel filled, packed or infused with suitable agents such as bioactive agents. Furthermore, the scaffolds are stiff but yet fracture resistant and with sufficient bending, compressive and torsional strength suitable for bone engineering. The slow degradation of the scaffold is sufficient for the 3D matrix to maintain structure integrity and mechanical properties during the remodelling process.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: April 22, 2014
    Assignees: Osteopore International PTE Ltd, Osteopore Korea Co. Ltd, National University of Singapore
    Inventors: Swee Hin Teoh, Hae-Ryong Song, Soi Khoon Yew, Kelvin Hong Yap Koh, Ji Hoon Bae, Joon Ho Wang
  • Patent number: 8686064
    Abstract: The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or be further processed to form an osteoimplant.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: April 1, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Lawrence A. Shimp, David Knaack
  • Patent number: 8673014
    Abstract: A method of cranial repair and the cranial implant molding device used therein, the device having a frame or base that receives a bottom or convex molding plate and a top or concave molding plate in a manner whereby the two plates are separated a distance to receive a settable or curable implant forming material therebetween. The plates are separated by a compressible member such that by the use of threaded mechanical fasteners or similar members the distance between the two plates can be adjusted by tightening or loosening the mechanical members. The thickness of the implant is varied by varying the separation distance on different sides of the frame.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: March 18, 2014
    Assignee: KLS-Martin, L.P.
    Inventors: Shawn Burke, Michael Teague, Pat Lemoyne
  • Publication number: 20140058527
    Abstract: The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or mixed polymers with allograft chondrocytes added in an amount ranging from 2.5×105 to 2.5×107.
    Type: Application
    Filed: October 31, 2013
    Publication date: February 27, 2014
    Applicant: Musculoskeletal Transplant Foundation
    Inventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
  • Patent number: 8652503
    Abstract: A bone paste useful in the orthopedic arts, for example in the repair of non-union fractures, periodontal ridge augmentation, craniofacial surgery, implant fixation, impaction grafting, or any other procedure in which generation of new bone is deemed necessary, is provided by a composition comprising a substantially bioabsorbable osteogenic compound in a gelatin matrix. In various embodiments, the osteogenic compound is selected from (i) demineralized bone matrix (DBM); (ii) bioactive glass ceramic, BIOGLASS®, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, or like material; (iii) bone morphogenetic protein, TGF-?, PDGF, or mixtures thereof, natural or recombinant; and (iv) mixtures of (i)-(iii).
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: February 18, 2014
    Assignees: University of Florida Research Foundation, Inc., Regeneration Technologies, Inc.
    Inventors: John F. Wironen, Jamie M. Grooms
  • Patent number: 8653029
    Abstract: The present invention provides a composition that may be used as an implant or a bone graft substitute or extender for filling voids and/or promoting fusion of osseous tissues. The implant may comprise ceramic granules such as calcium phosphate granules and one or more polysaccharide excipients, and may be in the form of a putty or flowable paste. Optionally, the implant may also comprise a growth factor such as a bone morphogenetic protein.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: February 18, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Scott Mitchell Vickers, Jeffrey L. Scifert
  • Publication number: 20140039640
    Abstract: Methods of providing dose controlled application of bone graft materials are disclosed. In particular, methods for determining a target quantity of bone graft material for clinical application in order to ensure maximum clinical results are provided. These methods comprise determining the target weight of the material to be applied.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 6, 2014
    Applicant: PROSIDYAN, INC.
    Inventors: Charanpreet S. BAGGA, Hyun W. Bae
  • Publication number: 20140031950
    Abstract: Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. In some embodiments, a bone graft composition includes a collagen matrix and a plurality of bioactive glass particulates dispersed throughout the collagen matrix. The collagen matrix is about 20% to about 60% by weight of the bone graft composition, and the bioactive glass is about 40% to about 80% of the bone graft composition. In some embodiments, a majority of the bioactive glass particulates are about 53 ?m to about 425 ?m in size.
    Type: Application
    Filed: October 7, 2013
    Publication date: January 30, 2014
    Inventors: Russell L. Cook, Duraid S. Antone
  • Patent number: 8632524
    Abstract: An injectable biocompatible material delivery system is disclosed and can include an injector and a material delivery cannula that can be in fluid communication with the injector. Further, the injectable biocompatible material delivery system can include a light source that can be configured to emit light to at least a portion of the injector, at least a portion of the material delivery cannula, or a combination thereof. Further, the light source can be configured to activate an injectable biocompatible material as it moves through the system.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: January 21, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Hai H. Trieu, Jeff R. Justis, Michael C. Sherman, Dimitri K. Protopsaltis
  • Patent number: 8623094
    Abstract: An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant comprising collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may be “matched” to provide the implant with similar physical and/or chemical properties as the host tissue.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: January 7, 2014
    Assignee: Kensey Nash BVF Technology LLC
    Inventors: Douglas G Evans, Scott M. Goldman, Russell T. Kronengold
  • Publication number: 20140005793
    Abstract: The present application is directed to the field of implants comprising processed hard or soft biological tissues for use in implantation in humans. The molded biological tissue implants of the present application are preferably made from allograft soft tissue sources and demineralized bone matrix. The present application provides biological implants exhibiting advantageous properties of absorption, expansion, resiliency and shape retention. The properties of the biological implants produced by the methods of the present application are leveraged in the creation and development of novel biological implant constructs and of novel methods of treatment and surgical technique.
    Type: Application
    Filed: March 12, 2013
    Publication date: January 2, 2014
    Inventors: Keith Cameron Koford, Nathaniel Scott Long, Erica Lee Scharringhausen, Randall Keith Hilliard
  • Patent number: 8617252
    Abstract: Methods, devices and compositions for fusing adjacent vertebrae, and otherwise localizing bone growth, are provided. In one form of the invention, a method for fusing adjacent vertebrae includes preparing a disc space for receipt of an intervertebral disc implant in an intervertebral disc space between adjacent vertebrae, inserting the implant into the intervertebral disc space and providing an osteoinductive composition that includes an osteoinductive factor in a pharmaceutically acceptable carrier. The carrier is advantageously substantially impermeable to efflux of the osteoinductive factor and is released as the carrier is resorbed or biodegraded. Preferred carriers include a hardened, resorbable carrier, such as a calcium phosphate cement that retains at least about 50% of the osteoinductive factors greater than about 2 days. Preferred osteoinductive factors are growth factors and include bone morphogenetic proteins and LIM mineralization proteins.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: December 31, 2013
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 8608743
    Abstract: An implant system includes a fixation device that, in turn can include an expandable implant alone or in combination with an auxiliary implant. The expandable implant includes an expandable implant body that is made from an expandable material. The expandable material includes a polymer matrix and an expandable gas source contained within at least a portion of the polymer matrix. The implant system can further include an energy source configured to heat the polymer matrix to a temperature above its glass transition temperature, thereby causing the gas source to expand inside the polymer matrix. The fixation device can further include an insertion instrument configured to implant the fixation device into an anatomical cavity.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: December 17, 2013
    Assignee: DePuy Synthes Products, LLC
    Inventors: Adrian Baumgartner, Robert Frigg, Cyril Voisard, Reto Nardini, Dieter Schmidli, Christian Brunner, Stefan Saladin
  • Patent number: 8603183
    Abstract: A bilayered bone graft device includes a core portion comprising deminernalized gelatin and a shell portion surrounding the core portion. The shell portion includes a calcium silicate and the deminernalized gelatin in a range of 1 to 30 weight percent, and the calcium silicate has a molar ratio of calcium to silicon ranging from 10 to 0.1. The core portion and the shell portion are bound by the deminernalized gelatin without using a binder. In one embodiment of the present invention, the core portion is configured to provide buffering for receiving an insertion, and the shell portion is configured to provide a load-bearing structure.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: December 10, 2013
    Inventor: Shinn Jyh Ding