Including Natural Bone Tissue Patents (Class 623/23.63)
  • Patent number: 10453537
    Abstract: A non-volatile memory includes a plurality of cells each individually capable of storing multiple bits of data including bits of multiple physical pages including at least a first page and a second page. A controller of the non-volatile memory determines a first calibration interval for a first read voltage threshold defining a bit value in the first page and a different second calibration interval for a second read voltage threshold defining a bit value in the second page. The second calibration interval has a shorter duration than the first calibration interval. The controller calibrates the first and second read voltage thresholds for the plurality of memory cells in the non-volatile memory based on the determined first and second calibration intervals.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: October 22, 2019
    Assignee: International Business Machines Corporation
    Inventors: Matt Reuter, Sasa Tomic, Nikolaos Papandreou, Timothy Fisher, Aaron D. Fry, Roman A. Pletka, Nikolas Ioannou, Charalampos Pozidis
  • Patent number: 10390864
    Abstract: An interspinous implant is provided. The interspinous implant can include a first member having a first end and a second end. At least one of the first end and the second end can include a mating portion. The interspinous implant can also include a second member, which can have a first end, a second end and at least one receiving portion formed adjacent to at least one of the first end and the second end. The at least one receiving portion can receive the mating portion to couple the first member to the second member at a desired orientation. The interspinous implant can also include a first extension, which can be substantially opposite the mating portion, and adapted to engage a spinous process. The interspinous implant can comprise a second extension, which can be substantially opposite the at least one receiving portion, and adapted to engage a second process.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: August 27, 2019
    Assignee: Zimmer Biomet Spine, Inc.
    Inventors: Garrett A Sheffer, Nathaniel E Hawkins
  • Patent number: 10335281
    Abstract: Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: July 2, 2019
    Assignee: ALLOSOURCE
    Inventors: Carolyn Barrett, Yaling Shi
  • Patent number: 10016527
    Abstract: In one embodiment, the present invention includes a method for repairing a cartilage defect including: preparing a cartilage defect by removing unwanted or damaged tissue; creating at least one perforation into or through subchondral bone, below and/or adjacent to the cartilage defect to induce the flow of bone fluid; allowing the bone fluid to bleed through the at least one perforation up into the cartilage defect to fill at least a portion of the cartilage defect; and applying a biomaterial into the defect to produce a clot for cartilage regeneration.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: July 10, 2018
    Assignee: Orthovita, Inc.
    Inventor: Marc Long
  • Patent number: 9999520
    Abstract: An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: June 19, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Albert Manrique, Jean T. Edwards, Nelson L. Scarborough, Scott D. Boden, Kathy Traianedes, Lawrence A. Shimp, James L. Russell
  • Patent number: 9968455
    Abstract: Disclosed herein are implants and methods for filling voids in a cranium of a patient. A craniofacial implant that may be used for filling such voids may include at least first and second components each having outer and inner surfaces, the outer and inner surfaces being curved in an inferior to posterior direction and a medial to lateral direction. The first component includes a flange extending outwardly from a medial side surface thereof and the second component includes a recessed portion extending inwardly from a medial side surface thereof. The first and second components are preferably engageable to one another such that the medial side surfaces of the first and second components are adjacent one another and the flange of the first component is housed within the recessed portion of the second component.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: May 15, 2018
    Assignee: Howmedica Osteonics Corp.
    Inventors: James J. Rudnick, Christopher Michael Bennett, Anthony Wolverton, Jason Wainwright
  • Patent number: 9949832
    Abstract: Bone implant compositions are provided that include a body made of cortical bone extending along an axis between a first end and a second end. The body includes an outer surface configured to engage host bone of a patient and at least one recess extending transverse to the axis into the outer surface of the body configured for disposal of an insert. At least one insert made of demineralized bone is disposed in the at least one recess.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: April 24, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 9943412
    Abstract: An implantable repair device for the repair, augmentation or replacement of tissue, uses silk fibroin and has a smooth surface and a porous surface. The smooth surface has a measured Sa value of less than approximately 0.1 ?m when using Atomic Force Microscopy when samples of the repair device are fully hydrated by imaging through fluid in peak force tapping mode. A method of preparing such an implantable repair device includes preparing a gel from a fibroin solution in a mold, preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel, and creating at least a porous surface on the device, wherein a portion of the mold is adapted to provide at least one smooth surface.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: April 17, 2018
    Assignee: ORTHOX LIMITED
    Inventor: Nicholas Skaer
  • Patent number: 9700415
    Abstract: Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: July 11, 2017
    Assignee: ALLOSOURCE
    Inventors: Carolyn Barrett, Yaling Shi
  • Patent number: 9700584
    Abstract: The present disclosure relates to osteoinductive putties and other implantable compositions for repair of bone defects and other medical uses. Specifically, the technology pertains to carriers for use in implantable compositions, such as osteoinductive putties. The osteoinductive putties are made entirely from donor tissue such as demineralized bone matrix, and the putties have excellent physical properties. The present disclosure relates to osteoinductive putties, carriers, compositions, implants, kits, methods of making and methods of using any of the foregoing.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: July 11, 2017
    Assignee: RTI Surgical, Inc.
    Inventor: Jordan Michael Katz
  • Patent number: 9603710
    Abstract: Osteochondral graft composition that include a cartilage component and a bone component, and which include one or more perforations in the bone component and/or the cartilage component, are provided. Methods of manufacturing and using such osteochondral graft compositions are also provided.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: March 28, 2017
    Assignee: AlloSource
    Inventors: Yaling Shi, Carolyn Barrett
  • Patent number: 9364582
    Abstract: Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids can include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising one or more polysaccharides. Also described are methods for making and using such medical compositions.
    Type: Grant
    Filed: September 21, 2011
    Date of Patent: June 14, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Susan J. Drapeau, Kathy L. Remsen, William F. McKay, Nelson L. Scarborough
  • Patent number: 9333276
    Abstract: Present inventions present composites of bone particles and polyurethane(s), as well as methods of making such composite and uses thereof. A porous composite comprises a plurality of bone particles; and polyurethanes with which the bone particles are combined. To prepare a porous composite, a composition comprise a plurality of bone particles, polyurethane precursors including polyisocyanate prepolymers and polyols, water and catalyst. A composition is either naturally moldable and/or injectable, or it can be made moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength for most orthopedic applications.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: May 10, 2016
    Assignees: Vanderbilt University, Warsaw Orthopedic, Inc.
    Inventors: Scott A. Guelcher, Subhabrata Bhattacharyya, Katarzyna Jadwiga Zienkiewicz, Shaun A. Tanner, Jerald E. Dumas
  • Patent number: 9272072
    Abstract: An osteoinductive bone graft substitute including an osteoinductive calcium phosphate component retained within a collagen scaffold, wherein the collagen scaffold is formulated to maintain the osteoinductivity of the calcium phosphate component while also exhibiting the following characteristics (1) ability to absorb bone marrow and/or other physiologic liquids, (2) compression resistance; (3) moldability; (4) retaining the calcium phosphate component during and after manipulation of the collagen scaffold and (5) fibrous collagen matrix that retains but does not occlude the osteoinductive calcium phosphate component.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: March 1, 2016
    Assignee: NuVasive, Inc.
    Inventors: Ali Ismailoglu, Frank Vizesi, Sung-Ching Chen, Po-Hung Lai, Kehsin Chien
  • Patent number: 9265609
    Abstract: Bone implant compositions are provided that include a body made of cortical bone extending along an axis between a first end and a second end. The body includes an outer surface configured to engage host bone of a patient and at least one recess extending transverse to the axis into the outer surface of the body configured for disposal of an insert. At least one insert made of demineralized bone is disposed in the at least one recess.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: February 23, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 9168140
    Abstract: Osteochondral graft composition comprising a cartilage component and a bone component, and further comprising one or more perforations in the bone component and/or the cartilage component, are provided. Methods of manufacturing and using osteochondral graft compositions comprising one or more perforations in the bone component and/or the cartilage component are also provided.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 27, 2015
    Assignee: AlloSource
    Inventors: Yaling Shi, Carolyn Barrett
  • Patent number: 9132208
    Abstract: The invention is directed to a process for making a tissue repair implant having a porous sponge-like structure to repair bone, cartilage, or soft tissue defects by producing a connective tissue homogenate from one or more connective tissues; mixing the connective tissue homogenate with a carrier solution to produce a connective tissue carrier; optionally mixing one or more natural or synthetic bone fragements with said connective tissue carrier to produce a tissue repair mixture; freezing or freeze-drying the tissue repair mixture to produce a porous sponge-like structure and create a three-dimensional framework to entrap the natural or synthetic bone fragments, treating the frozen or freeze-dried porous sponge-like structure with one or more treatment solutions to produce a stabilized porous sponge-like structure. A crudely fragmented connective tissue from one or more connective tissues is optionally mixed with the tissue repair mixture before freezing or freeze-drying.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: September 15, 2015
    Assignee: LifeNet Health
    Inventors: Silvia S. Chen, Jingsong Chen, Lloyd Wolfinbarger, Jr.
  • Patent number: 9125871
    Abstract: The invention proposes a cell-free graft, comprising (i) a cohesive, structure-forming matrix with open porosity made from a biologically and pharmaceutically acceptable material and (ii) serum. In one particularly preferred embodiment, the matrix additionally contains a gel. By virtue of a second aspect, a method of producing such a cell-free graft is proposed, whereby the matrix and the gel, if one is provided, is placed in contact with the serum. The graft may optionally be dried with serum. Alternatively, the matrix and the gel, if one is provided, are in the dried state before being placed in contact with the serum. By virtue of a third aspect, finally, the invention proposes the use of the cell-free graft for regenerating tissue and in particular for regenerating cartilage and/or bone.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: September 8, 2015
    Assignee: BioTissue AG
    Inventors: Michael Sittinger, Eszter Tánczos, Christian Kaps
  • Patent number: 9107983
    Abstract: Osteoconductive matrices and methods are provided that have one or more statins disposed therein. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustain release of the statin and facilitate bone formation and repair of the fracture site.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: August 18, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 9056017
    Abstract: A method of designing, presenting, generating, and fabricating custom implants by obtaining a 3D image of a site to receive an implant, simulating volumetric changes of the site, generating a virtual 3D implant, and fabricating a real 3D implant. A method of implanting a custom implant in a patient, by obtaining a 3D image of a site to receive an implant, simulating volumetric changes of the site, generating a virtual 3D implant, fabricating a real 3D implant, and implanting the implant in the patient. A method of correcting disfigurement in a patient. A method of replacing a disc in a patient's back. The present invention also provides for an implant fabricated by this method.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: June 16, 2015
    Inventor: Brett Kotlus
  • Patent number: 8926710
    Abstract: Osteoconductive bone graft materials are provided. These compositions contain injectable cements and demineralized bone matrix fibers. The combination of these materials enables the filling of a bone void while balancing strength and resorption.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: January 6, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 8840677
    Abstract: The present invention provides a system, device, instruments and methods for inserting and/or improving the holding strength and purchase of a bone screw, bone pin, or bone dowel in bone. Embodiments include monolithic allograft tissue forms, multi-piece allograft tissue forms, distally expandable portions, partially and fully demineralized portions, and flexible connecting portions. Advantages of the allograft tissue forms of the present invention include improved pedicle screw blackout strength and improved filling of bone voids. Methods for making and instruments and techniques for inserting the augmentation device, system and screws or pins are also disclosed.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: September 23, 2014
    Assignee: DePuy Synthes Products, LLC
    Inventors: Shreedhar Kale, Dennis Chien, Robert Delurio, Curtis Compton
  • Publication number: 20140277570
    Abstract: This disclosure describes systems and methods for providing a novel delivery system for implantation in a patient. Further, this disclosure describes a delivery system including a carrier that is made of at least one monolithic bone tissue for retaining one or more substances.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: LANX, INC.
    Inventors: Keyvan Behnam, Jeffrey Thramann, Elizabeth Perez
  • Publication number: 20140243979
    Abstract: A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.
    Type: Application
    Filed: May 1, 2014
    Publication date: August 28, 2014
    Applicant: The Regents of the University of Michigan
    Inventors: Ellen M. Arruda, Lisa M. Larkin, Fatima N. Syed-Picard, Michael Smietana, Jinjin Ma
  • Patent number: 8795361
    Abstract: Each of an osteochondral plug graft and a kit comprises a trapezoid shaped construct configured for osteochondral implanting. An osteochondral regeneration method comprises forming a recipient socket in a chondral area of an articular joint in need of repair; harvesting a trapezoid shaped graft from another chondral area; and implanting the trapezoid shaped graft into the recipient socket.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: August 5, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Jeffrey H Nycz, Keith M Kinnane, Susan J Drapeau, Daniel A Shimko, Jeetendra S Bharadwaj
  • Publication number: 20140212471
    Abstract: An osteoinductive implantable composition comprising a mixture of demineralized bone fibers and mineralized bone fibers is provided. The mixture is visible under X ray and remodels more easily than comparable mixtures of demineralized bone matrix and surface demineralized cortical bone chips. The osteoinductive implantable compositions comprises demineralized bone fibers in an amount from about 30 vol % to about 45 vol % and mineralized bone fibers in an amount from about 55 vol % to about 70 vol %. The osteoinductive implantable compositions can be delivered in delivery systems including mesh coverings for administration at surgical sites. A method of treating a bone defect caused by injury, disease, wounds, or surgery utilizing the osteoinductive implantable composition comprising a mixture of demineralized bone fibers and mineralized bone fibers is also provided.
    Type: Application
    Filed: January 28, 2013
    Publication date: July 31, 2014
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Susan J. Drapeau, Guobao Wei
  • Publication number: 20140195005
    Abstract: Bone implant compositions are provided that include a body made of cortical bone extending along an axis between a first end and a second end. The body includes an outer surface configured to engage host bone of a patient and at least one recess extending transverse to the axis into the outer surface of the body configured for disposal of an insert. At least one insert made of demineralized bone is disposed in the at least one recess.
    Type: Application
    Filed: January 8, 2013
    Publication date: July 10, 2014
    Applicant: Warsaw Orthopedic, Inc.
    Inventor: WILLIAM F. MCKAY
  • Patent number: 8740987
    Abstract: An implant including a substantially cohesive aggregate comprising bone-derived particles. Cohesiveness is maintained by a member of mechanical interlocking, engagement of adjacent bone-derived particles with one another through engagement with a binding agent, thermal bonding, chemical bonding, or a matrix material in which the bone-derived particles are retained. The aggregate is shaped as a one-dimensional or two-dimensional body.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: June 3, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Perry Geremakis, Jennifer Grasso, David Knaack, Jo-Wen Lin, Lawrence Shimp, Robert Waterman, John Winterbottom
  • Patent number: 8734525
    Abstract: An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: May 27, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Keyvan Behnam, Nanette Forsyth, James Russell, John Winterbottom, Todd Boyce
  • Patent number: 8702809
    Abstract: The present invention provides a cancellous bone scaffold to use in the replacement or repair of connective tissue such as ligaments and tendons. The cancellous bone scaffold has a fully demineralized segment with at least one adjacent mineralized end segment.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: April 22, 2014
    Assignee: Purdue Research Foundation
    Inventors: Eric A. Nauman, Darryl A. Dickerson
  • Patent number: 8686064
    Abstract: The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or be further processed to form an osteoimplant.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: April 1, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Lawrence A. Shimp, David Knaack
  • Patent number: 8673019
    Abstract: Methods and compositions are provided for reduction of inflammation and improved allograft/host tissue integration comprising placing at least one anti-inflammatory compound onto a site of the defect and placing a graft structure onto the site of the defect.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: March 18, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 8652503
    Abstract: A bone paste useful in the orthopedic arts, for example in the repair of non-union fractures, periodontal ridge augmentation, craniofacial surgery, implant fixation, impaction grafting, or any other procedure in which generation of new bone is deemed necessary, is provided by a composition comprising a substantially bioabsorbable osteogenic compound in a gelatin matrix. In various embodiments, the osteogenic compound is selected from (i) demineralized bone matrix (DBM); (ii) bioactive glass ceramic, BIOGLASS®, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, or like material; (iii) bone morphogenetic protein, TGF-?, PDGF, or mixtures thereof, natural or recombinant; and (iv) mixtures of (i)-(iii).
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: February 18, 2014
    Assignees: University of Florida Research Foundation, Inc., Regeneration Technologies, Inc.
    Inventors: John F. Wironen, Jamie M. Grooms
  • Publication number: 20140005793
    Abstract: The present application is directed to the field of implants comprising processed hard or soft biological tissues for use in implantation in humans. The molded biological tissue implants of the present application are preferably made from allograft soft tissue sources and demineralized bone matrix. The present application provides biological implants exhibiting advantageous properties of absorption, expansion, resiliency and shape retention. The properties of the biological implants produced by the methods of the present application are leveraged in the creation and development of novel biological implant constructs and of novel methods of treatment and surgical technique.
    Type: Application
    Filed: March 12, 2013
    Publication date: January 2, 2014
    Inventors: Keith Cameron Koford, Nathaniel Scott Long, Erica Lee Scharringhausen, Randall Keith Hilliard
  • Patent number: 8609127
    Abstract: Embodiments of the invention include a medical device and a method of manufacturing a medical device having a porous scaffold in combination with a bioactive material. In some embodiments, particularly limited thicknesses of the bioactive material are applied within pores of the porous structure.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: December 17, 2013
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Heather M. Savage-Erickson
  • Patent number: 8579986
    Abstract: The present invention provides an apparatus and method that will allow surgeons to produce bone growth masses for use in spinal surgery that are capable of maintaining their physical integrity during placement and during the acute post operative period.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: November 12, 2013
    Assignee: University of South Florida
    Inventors: Thomas B. Freeman, Wesley M. Johnson, Ben Guiot
  • Publication number: 20130297038
    Abstract: Bone implant compositions and methods are provide that have an outer surface, the outer surface comprising demineralized bone and having a cavity disposed in the outer surface, the cavity having a demineralized bone material coated therein; and an inner surface of the bone implant comprising cortical bone, the inner surface contacting the outer surface. The bone implant compositions and methods provided are osteoinductive and allow rapid bone fusion.
    Type: Application
    Filed: May 7, 2012
    Publication date: November 7, 2013
    Applicant: Warsaw Orthopedic, Inc. An Indiana Corporation
    Inventor: William F. McKay
  • Publication number: 20130282128
    Abstract: A bone graft implant device for treating a tissue site is provided, the device including an implant body including a demineralized allograft bone material portion, and at least one engagement member protruding from the implant body including a mineralized allograft bone material portion. The engagement member may be integrally formed with the implant body, or alternatively, the implant body may include an aperture and the engagement member may be insertable therein. At least one of the amount of demineralization or area of the demineralized allograft bone material portion is adjustable to impart a desired flexibility to the implant body.
    Type: Application
    Filed: April 24, 2012
    Publication date: October 24, 2013
    Applicant: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Publication number: 20130274892
    Abstract: The present invention relates to an electrospun chitosan scaffold. The scaffold mimics natural bone mechanical properties and structure through mineralization without hindering the biocompatibility for osteoblasts. The electrospun mineralized scaffold is useful in bone regeneration therapies.
    Type: Application
    Filed: October 7, 2011
    Publication date: October 17, 2013
    Applicant: Drexel University
    Inventors: Peter I. Lelkes, Michael Frohbergh
  • Publication number: 20130274890
    Abstract: A composite interbody bone implant device is provided including a body having a non-bone composition, such as a polymer, formed into a shape and including one or more cavities. An osteoinductive material, such as bone allograft tissue, may be retained in the one or more cavities of the body. The body is formable via injection molding and/or machining into a shape and size adapted for implantation at a surgical site. The dimensions of the body include a length, a width and a thickness, and the thickness of the body may be less than at least one of the length and width.
    Type: Application
    Filed: April 17, 2012
    Publication date: October 17, 2013
    Applicant: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Publication number: 20130173014
    Abstract: Systems, methods and compositions useful for treatment of traumatic bone injuries are provided. In one embodiment, a bone reconstruction system comprising a space maintaining composition comprising porous polymethylmethacrylate; and an osseous generating construct comprising a polymethylmethacrylate chamber that comprises one or more osseous generating materials is provided. Associated compositions and methods are also provided.
    Type: Application
    Filed: July 13, 2012
    Publication date: July 4, 2013
    Inventors: Antonios G. Mikos, Mark E. Wong, Simon W. Young, Meng Shi, F. Kurtis Kasper, Patrick Spicer, James D. Kretlow
  • Publication number: 20130131826
    Abstract: An artificial bone-cartilage composite comprising a first composite material layer comprising collagen, proteoglycan and hyaluronic acid, and a second composite material layer comprising collagen and calcium phosphate, which are bonded to each other via a bonding layer comprising collagen, proteoglycan, hyaluronic acid and calcium phosphate.
    Type: Application
    Filed: November 7, 2012
    Publication date: May 23, 2013
    Applicant: HOYA CORPORATION
    Inventor: HOYA CORPORATION
  • Publication number: 20130079889
    Abstract: There is disclosed an irradiated cortical bone sheet allograft. In an embodiment, the allograft includes a unitary sheet of at least partially demineralized, irradiated cortical bone having a thickness, a width, and a length. The thickness of the unitary sheet of irradiated cortical bone is less the width and the length. In another embodiment, a method of forming the allograft includes obtaining a natural bone from a donor different than a recipient. The natural bone contains a layer of a cortical bone. The method includes cleaning the natural bone to produce a unitary sheet of cortical bone. The method includes at least partially demineralizing the unitary sheet of cortical bone. The method includes freezing the unitary into a frozen state within a sealed package. The method includes irradiating the unitary sheet in the frozen state within the sealed package to sterilize the cortical bone and produce the irradiated cortical bone sheet for implantation in the recipient other than the donor.
    Type: Application
    Filed: September 27, 2012
    Publication date: March 28, 2013
    Inventor: Deborah Marie Spillman
  • Publication number: 20130030547
    Abstract: A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged in a core/outer layer structure.
    Type: Application
    Filed: January 28, 2012
    Publication date: January 31, 2013
    Inventor: Brian Burkinshaw
  • Patent number: 8353967
    Abstract: A biocompatible, self-supporting, curved, collagen membrane adapted to be secured by bone tacks or bone screws over exposed bone at a desired bone graft site in the alveolar ridge of a patient such that the membrane defines a space having a predetermined height and width over the exposed bone, in which the membrane maintains its structural integrity for at least 4 months after implantation at the bone graft site and then naturally breaks down and is resorbed by the patient's body, a method of making such a membrane, and a method of using such a membrane for vertical augmentation of the alveolar ridge of the patient.
    Type: Grant
    Filed: August 10, 2010
    Date of Patent: January 15, 2013
    Assignee: Osseous Technologies of America
    Inventors: Jay Malmquist, David Cheung, William Knox
  • Publication number: 20130013080
    Abstract: A prosthetic system that includes a prosthetic implant and a support structure secured to an inner surface of a cavity of a bone is disclosed. The support structure defines a channel that extends through the length of the support structure. The prosthetic implant is received in the channel, and a portion of the prosthetic implant is secured to an inner surface of the support structure by an adhesive. The support structure may comprise a pair of partially hemispherical components arranged in spaced apart relationship thereby defining the channel between the pair of components.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: Zimmer, Inc.
    Inventors: Arlen D. Hanssen, David G. Lewallen
  • Publication number: 20130013071
    Abstract: An osteoimplant is made up of a coherent aggregate of elongate bone particles.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Randal R. Betz, Scott D. Boden, Christine Clark, Nanette Forsyth, John W. Morris, Kathy Traianedes
  • Patent number: 8343229
    Abstract: Implantable pliable bone blocks comprising a solid block of cortical bone characterized by a length, width and thickness, having a first and a second face on opposite sides of the block. The first and second faces have a plurality slot features. The angle of incidence of the slot features of the first face and the x-axis and the angle of incidence of the slot features of the second face and the x-axis (a2) are such that the slots would intersect if they were in the same plane. Methods are provided for making implantable pliable bone blocks.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: January 1, 2013
    Assignee: EBI, LLC
    Inventor: Bradford J. Coale
  • Publication number: 20120330436
    Abstract: A bone graft substitute in the form of an implantable three-dimensional scaffold that includes calcium phosphate and has pores. The scaffold is impregnated with a calcium and/or phosphate containing substance, and the dissolution rate DRS of the scaffold is slower than the dissolution rate DRD of the calcium and/or phosphate containing substance.
    Type: Application
    Filed: March 9, 2010
    Publication date: December 27, 2012
    Applicant: MATHYS AG BETTLACH
    Inventors: Marc Bohner, Reto Luginbuhl
  • Patent number: 8328876
    Abstract: The present invention provides methods of improving the osteogenic and/or chondrogenic activity of a bone matrix, e.g., a dermineralized bone matrix (DBM), by exposing the bone matrix to one or more treatments or conditions. In preferred embodiments the bone matrix is derived from human bone. The treatment or condition may alter the structure of the bone matrix and/or cleave one or more specific proteins. Cleavage may generate peptides or protein fragments that have osteoinductive, osteogenic, or chondrogenic activity. Preferred treatments include collagenase and various other proteases. The invention further provides improved bone and cartilage matrix compositions that have been prepared according to the inventive methods and methods of treatment using the compositions. The invention further provides methods of preparing, testing, and using the improved bone matrix compositions.
    Type: Grant
    Filed: December 31, 2004
    Date of Patent: December 11, 2012
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Keyvan Behnam, Christopher Cioffi