Using Radiant Energy Patents (Class 702/28)
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Patent number: 7890157Abstract: A method and system for analysis of fluorescence emission spectroscopy data and fluorescence lifetime imaging microscopy data are described. A unique Laguerre expansion can be found for fluorescence intensity decays of arbitrary form with convergence to a correct solution faster than with conventional methods. The Laguerre expansion technique includes expansion coefficients highly correlated with intrinsic fluorescence lifetimes, allowing direct characterization of fluorescence dynamics. For complex systems, conventional analysis of fluorescence intensity decay in terms of discrete exponential components can not readily provide a true representation of underlying fluorescence dynamics. Utilizing the Laguerre expansion technique, an alternative non-parametric method for analysis of time-resolved fluorescence data from various systems is described, facilitating characterization and discrimination of a sample.Type: GrantFiled: August 19, 2004Date of Patent: February 15, 2011Assignee: Cedars-Sinai Medical CenterInventors: Javier A. Jo, Laura Marcu, Qiyin Fang, Thanassis Papaioannou
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Publication number: 20110035161Abstract: An analog signal measurement system and a gamma ray detector with targeted automated gamma spectroscopy for gamma radiation surveillance system are disclosed. The analog signal measurement system has dynamically programmable lower and upper level discriminators for measuring an analog signal thereagainst, and logic devices for receiving input from the discriminators to generate digital signals. The gamma ray detector comprises a gamma ray detector for converting a gamma ray photon into an analog pulse, and a single channel analyzer or the analog signal measurement system.Type: ApplicationFiled: April 15, 2009Publication date: February 10, 2011Inventors: Robert Cassin McFadden, Christopher James McInnis Clarke
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Patent number: 7881878Abstract: Certain exemplary embodiments comprise a method, which can comprise automatically causing a representation of body tissue to be rendered. The body tissue can be tracked via clusters. The clusters each can comprise a predetermined number of particles. Each particle of a particular cluster can be representative of a discreet path associated with the particular cluster in a tensor field.Type: GrantFiled: April 5, 2006Date of Patent: February 1, 2011Assignee: Siemens Medical Solutions USA Inc.Inventors: Nicolas Burrus, Mariappan S. Nadar
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Publication number: 20110022324Abstract: Systems and methods disclosed include: a support apparatus configured to detachably receive a chip; movable pins extendible from a first position to a second position, where, in the first position, the movable pins do not contact a chip positioned on the support apparatus, and in the second position, the movable pins contact electrical terminals of a heating element within a chip positioned on the support apparatus; a radiation source configured to direct radiation to be incident on a chip positioned on the support apparatus; a detector; and an electronic processor, the electronic processor being configured to detect molecules in a sample positioned within the chip, and to determine a temperature of the chip by measuring an electrical resistance between two of the multiple pins connected to the electrical terminals.Type: ApplicationFiled: March 11, 2010Publication date: January 27, 2011Inventors: Kevin J. Knopp, Daryoosh Vakhshoori, Peidong Wang, Masud Azimi, Scott E. Miller, Jason Goldstein, Stephen McLaughlin
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Patent number: 7863556Abstract: A mass spectrum is generated by a process in which, from a mass scan signal comprising original samples defining a peak, a subset of the original samples defining the peak is selected. One or more synthesized samples are synthesized from the subset of the original samples. The one or more synthesized samples provide a temporal resolution greater than the temporal resolution of the original samples. The one or more synthesized samples are summed with respective temporally-aligned accumulated samples to produce the mass spectrum. The accumulated samples are obtained from mass scan signals generated during respective previously-performed mass scan operations.Type: GrantFiled: September 30, 2008Date of Patent: January 4, 2011Assignee: Agilent Technologies, Inc.Inventors: August Hidalgo, John Fjeldsted, William Frazer
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Publication number: 20100332146Abstract: A new method is presented for characterizing the associative properties of a solution of macromolecules at high concentration. Sample aliquots spanning a range of concentrations are injected sequentially into a light scattering photometer. Equilibrium association constants and association stoichiometry are derived from an analysis of the angular and concentration dependence of the scattering signals. Thermodynamic nonideality, which becomes important at high concentrations, is dealt with in the analysis in a simplified manner which is applicable to multiple associated species.Type: ApplicationFiled: June 30, 2009Publication date: December 30, 2010Applicant: Wyatt Technologies CorporationInventor: Daniel I. Some
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Publication number: 20100318302Abstract: A simplified X-ray imaging apparatus is capable of computationally determining effective atomic numbers with small error factors even for light elements. The X-ray imaging apparatus has an X-ray generation unit 101 (400) for generating X-rays and a detector 105 (405) for detecting X-rays transmitted through an object of examination 104 (403). A computing unit 106 (406) computationally determines a quantity of an X-ray phase attributable to the object of examination and an X-ray transmittance of the object of examination from data detected by the detector. The computing unit also computationally determines an effective atomic number of the object of examination from ?et determined from the quantity of the X-ray phase and ?t determined from the X-ray transmittance.Type: ApplicationFiled: March 11, 2009Publication date: December 16, 2010Applicant: CANON KABUSHIKI KAISHAInventors: Taihei Mukaide, Kazuhiro Takada, Masatoshi Watanabe
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Publication number: 20100299081Abstract: The invention relates to the detection and quantification of polypeptides using mass spectrometry. Specifically, the invention provides a method for testing whether a target polypeptide is present in a sample of a set of polypeptides, a method for deriving a value for distinguishing polypeptides of a set of polypeptides from each other, a database containing values for distinguishing each polypeptide of a set of polypeptides from each other, and an apparatus for configuring a mass scan of a mass spectrometer to test whether a target polypeptide of a set of polypeptides is present in a sample of the set.Type: ApplicationFiled: December 18, 2007Publication date: November 25, 2010Applicant: MACQUARIE UNIVERSITYInventors: Keith Ashman, Matthew McKay, Jamie Sherman, Mark Molloy
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Publication number: 20100274501Abstract: A precision molecular and motion sensor utilizing a Dispersed Fourier Transform Spectrometer to remotely sense targets. Remote sensing is conducted at various ranges, against various ambient backgrounds, to detect, classify, identify, characterize, and discriminate targets. A Dispersed Fourier Transform Spectrometer is expanded by modification and augmentation of existing optical, mechanical, and software components to enable basic terrestrial use while providing specific optimization for various applications which are designed with emphasis on the sensitivity of the Dispersed Fourier Transform Spectrometer.Type: ApplicationFiled: October 22, 2008Publication date: October 28, 2010Inventors: Douglas A. Rekenthaler, Arsen A. Hajian, Douglas G. Currie, Andrei V. Smirnov
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Patent number: 7813882Abstract: A new method is presented for measuring the molecular properties of an unfractionated solution of macromolecules. Sample aliquots spanning a range of concentrations are injected sequentially into a stream of solution and flow towards the detectors. Each aliquot produces, thereby, an effective “peak” whose elements correspond to different concentrations of the diluted aliquot. The weight averaged molar mass, the mean square radius, and the second virial coefficient of the macromolecules in solution are derived from an analysis of the angular and concentration dependence of the scattering signals throughout the corresponding peaks. In contrast to earlier on-line methods, better accuracy is achieved, while using a smaller quantity of sample. A similar method for determining cross virial coefficients between two distinct species of macromolecules is also presented.Type: GrantFiled: February 29, 2008Date of Patent: October 12, 2010Assignee: Wyatt Technology CorporationInventors: Daniel I. Some, Steven P. Trainoff
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Patent number: 7812312Abstract: The invention relates to an infrared measuring device, especially for the spectrometry of aqueous systems. Said device comprises at least one measuring unit, especially a measuring cell, also comprising at least one ATR-body and at least one infrared light source. The measuring unit contains at least one ATR-body which comprises at least two planar, substantially parallel limiting surfaces and which is transparent with respect to measuring radiation and which has an index of refraction which is greater than that of the medium which is arranged next to at least one limiting surface and which is to be examined, especially larger or equal to 1.5. The IR-measuring radiation on at least one of the planar, parallel limiting surfaces of the ATR-body can be totally reflected in an attenuated manner by at least six times.Type: GrantFiled: April 3, 2003Date of Patent: October 12, 2010Assignee: Johann Wolfgang Goethe-UniversitaetInventors: Werner Mäntele, Oliver Klein, Christian Zscherp, Andreas Barth, Hermann Von Lillienfeld-Toal, Hellmuth Von Prollius, Frithjof von Germar, Heribert Offermanns
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Publication number: 20100250468Abstract: A system to form an actual sales value or actual delivery value for all components of a commingled hydrocarbon fluid stream using mass, volume and energy, to create a theoretical commingled hydrocarbon fluid stream molecular composition and present the information on individual components in the commingled hydrocarbon fluid stream instantaneously to a buyer and a seller.Type: ApplicationFiled: March 24, 2009Publication date: September 30, 2010Applicant: SPL, INC.Inventors: William Joseph Theriot, Mark Reese Brown, Joseph Edward Landes, William J. Wild, Herman Reese Brown
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Patent number: 7804062Abstract: A method of obtaining pure component mass spectra or pure peak elution profiles from mass spectra of a mixture of components involves estimating number of components in the mixture, filtering noise, and extracting individual component mass spectra or pure peak elution profiles using blind entropy minimization with direct optimization (e.g. downhill simplex minimization). The method may be applied to deconvolution of pure GC/MS spectra of overlapping or partially overlapping isotopologues or other compounds, separation of overlapping or partially overlapping compounds in proteomics or metabolomics mass spectrometry applications, peptide sequencing using high voltage fragmentation followed by deconvolution of the obtained mixture mass spectra, deconvolution of MALDI mass spectra in the separation of multiple components present in a single solution, and specific compound monitoring in security and/or environmentally sensitive areas.Type: GrantFiled: April 4, 2007Date of Patent: September 28, 2010Assignee: National Research Council of CanadaInventors: Juris Meija, Zoltan Mester
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Patent number: 7791018Abstract: Methods and systems for measuring charges deposited on resistive and/or pixilated electrodes are described. The system includes a Time-of-Flight (TOF) detector with precise timing information provided by a discriminator implemented as a combination of a leading edge discriminator and a constant fraction discriminator. The discriminator initiates acquisition of the peak amplitude for accurate TOF measurements substantially independent of the signal amplitude at the input of the discriminator. The disclosed charge detection electronics has applications for space-based experiments.Type: GrantFiled: July 19, 2006Date of Patent: September 7, 2010Assignee: University of New HampshireInventor: Brian J. King
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Publication number: 20100223016Abstract: A method and apparatus for the identification and detection of composition of a liquid are disclosed. The invention involves detecting and collecting spectroscopically resolvable information about incident radiation, and collecting one or more datasets of intensity information at the detector system. Each dataset is resolved across at least three frequency bands within the spectrum of the source to produce an intensity data item for each band. A numerical relationship is evaluated for at least two pairs of frequency bands in a given intensity dataset to obtain a numerical indicator functionally related to a characteristic physical material property such as a material coefficient that varies functionally with radiation energy. The numerical indicator is compared with a library of data for a range of potential component liquids in order to obtain an indication of the likely composition of the liquid sample. An apparatus for use in identifying and detecting a liquid is also disclosed.Type: ApplicationFiled: August 15, 2008Publication date: September 2, 2010Inventors: Gary Gibson, Max Robinson
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Publication number: 20100217537Abstract: System and method for assessing the occurrence of an unknown substance in a sample that comprises multiple entities. A reference library is provided comprising a plurality of reference data sets representative of at least one known substance. A first feature of the entities is assessed wherein the first feature is characteristic of the unknown substance. A region of interest is selected wherein the region of interest comprises at least one entity exhibiting the first feature. A spatially accurate wavelength resolved Raman image is obtained wherein each pixel in the image is the Raman spectrum of the sample at the corresponding location. The spatially accurate wavelength resolved image is assessed to thereby identify the unknown substance.Type: ApplicationFiled: March 5, 2010Publication date: August 26, 2010Applicant: Chemlmage CorporationInventors: Jason Neiss, Patrick Treado, Robert C. Schweitzer
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Publication number: 20100211329Abstract: The method and apparatus are used to determine class, grade and properties of fuel samples, regardless of ambient, instrument, or sample temperature, using mathematical correlations between fuel class, grade and properties and their spectra developed from a database of samples with measured properties and spectra. The ability to measure a fuel sample using the present method and apparatus is useful in identifying unknown fuel samples, determining suitability in equipment, and monitoring and controlling fuel processes, such as blending operations, distillation, and synthesis.Type: ApplicationFiled: October 10, 2008Publication date: August 19, 2010Inventors: Stuart Farquharson, Wayne W. Smith
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Publication number: 20100211328Abstract: The invention provides a method for identifying the impacts of interfering effects on experimental data. In particular, a method is described for identifying the impacts of unwanted auto-fluorescence, fluorescence quenching, and deterioration of a fluorescent sample under study on the collected experimental data. The data are analyzed whether or not said data fulfill certain criteria with respect to a threshold which is indicative for said interfering effect.Type: ApplicationFiled: January 29, 2010Publication date: August 19, 2010Inventors: Christian Eggeling, Kaupo Palo, Nicolas Fay, Maciej Hoffman-Wecker, Pierre Ilouga
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Patent number: 7778783Abstract: A substance analyzer utilizing Prompt Gamma Neutron Activation Analysis for identifying characteristics of a substance and method of manufacturing the same are disclosed. The analyzer is small enough to be portable and to allow its use in many applications where current analyzers cannot be utilized. The analyzer uses a neutron radiation source and a gamma-ray detector to activate the sample material and detect the prompt gamma rays emitted by the sample material. A novel housing for such an analyzer and method for making the housing are also described. Novel methods of operating such an analyzer including via a communications network are also disclosed. Also disclosed are data analysis methods that improve the accuracy and sensitivity of the results of such material analysis.Type: GrantFiled: December 18, 2006Date of Patent: August 17, 2010Assignee: Sabia, Inc.Inventors: Clinton L. Lingren, David B. Cook, James F. Miller, Stephen J. Foster
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Publication number: 20100179770Abstract: A system and method for determining at least one geometric property of a particle in a sample. A sample is irradiated to thereby generate Raman scattered photons. These photons are collected to generate a Raman chemical image. A first threshold is applied wherein the first threshold is such that all particles in the sample are detected. A particle in the sample is selected and a second threshold is applied so that at least one geometric property of the selected particle can be determined. At least one spectrum representative of the selected particle is analyzed to determine whether or not it is a particle of interest. The step of determining a second threshold may be iterative and automated via software so that candidate second thresholds are applied until a satisfactory result is achieved.Type: ApplicationFiled: January 8, 2010Publication date: July 15, 2010Applicant: ChemImage CorporationInventors: Michael Fuhrman, Ryan Priore, Oksana Olkhovyk, Oksana Klueva
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Patent number: 7720612Abstract: The present invention relates to methods for resolving convoluted peaks in a chromatogram into one or more constituent peaks using peak resolution values. The peaks methods of the invention determine empirical peak resolution values of “well-defined” or “isolated” peaks in the data, then extrapolate these empirical resolution values to peaks in neighboring regions to predict the number of constituent peaks at a given peak position. Predicted peak resolution values are compared to observed peak resolution values of low-resolution or convoluted peaks to determine the number of constituent peaks in the convoluted peaks. These methods enable extension of the region of data that can used for identifying nucleotide sequences, and increase base-calling accuracy in the low-resolution region (end region) of data.Type: GrantFiled: February 6, 2007Date of Patent: May 18, 2010Assignee: Siemens Healthcare Diagnostics, Inc.Inventors: Alexandre M. Izmailov, Murugathas Yuwaraj
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Patent number: 7713741Abstract: The invention is directed to a method and a kit for calibrating a photoluminescence measurement system, in particular a fluorescence measurement system. The kit includes a number of fluorescence standards i and their corrected and certified fluorescence spectra Ii(?), whereby the fluorescence standards i are selected, so that their spectrally corrected fluorescence spectra Ii(?) cover a broad spectral range with high intensity. The standards are characterized by large half-widths FWHMi of their bands of at least 1400 cm?1. According to the method of the invention, partial correction functions Fi(?) are generated by forming the quotient of the measured fluorescence spectra Ji(?) and the corresponding corrected fluorescence spectra Ii(?), which are then combined to form a total correction function F(?) for a broad spectral range.Type: GrantFiled: September 9, 2005Date of Patent: May 11, 2010Assignees: BAM Bundesanstalf fur Materialforschung und - prufung, Fluka GmbHInventors: Ute Resch-Genger, Dietmar Pfeifer, Christian Monte, Angelika Hoffmann, Pierre Nording, Bernhard Schönenberger, Katrin Hoffmann, Monika Spieles, Knut Rurack
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Patent number: 7711496Abstract: A process system adapted for processing of or with a material therein. The process system includes: a sampling region for the material; an infrared photometric monitor constructed and arranged to transmit infrared radiation through the sampling region and to responsively generate an output signal correlative of the material in the sampling region, based on its interaction with the infrared radiation; and process control means arranged to receive the output of the infrared photometric monitor and to responsively control one or more process conditions in and/or affecting the process system.Type: GrantFiled: May 13, 2008Date of Patent: May 4, 2010Assignee: Advanced Technology Materials, Inc.Inventor: Jose I. Arno
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Patent number: 7698080Abstract: Methods for determining the most likely composition of sample are disclosed. The methods can include: obtaining data from a sample, where the data includes a representation of a measured spectrum; determining a precision state of the representation of the measured spectrum; providing a plurality of library candidates; for each library candidate, providing data representing each library candidate, where the data includes a representation of a library spectrum; determining a representation of the similarity of the sample to each library candidate; determining the most likely composition of the sample based upon the determined representations of similarity of the sample to each library candidate; and displaying the most likely composition of the sample to a user.Type: GrantFiled: August 7, 2007Date of Patent: April 13, 2010Assignee: Ahura CorporationInventors: Christopher D. Brown, Gregory H. Vander Rhodes
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Publication number: 20100070199Abstract: A system for measuring properties of a medium includes an electromagnetic generator for forming a CW carrier, a digital encoder for forming a digital message, and a modulator for modulating the CW carrier with the digital message to form a digitally modulated CW carrier. The medium provides a channel for propagating the digitally modulated CW carrier. The system further includes a receiver configured to receive the propagated, digitally modulated CW carrier, and a processor for measuring at least one property of the medium. The medium may be disposed within a gaseous atmosphere, a body of water, or a cell of a laboratory.Type: ApplicationFiled: September 24, 2009Publication date: March 18, 2010Applicant: ITT MANUFACTURING ENTERPRISES, INC.Inventors: SCOTT NELSON MENDENHALL, Michael E. Dobbs, Benjamin R. Neff, James Alexander McAdoo
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Publication number: 20100065745Abstract: A method and system for high Z substance revealing using muon detection technique is presented. Natural muon coordinate and incidence angle are measured above and below the interrogated volume. The muon deviations after passing through the interrogated volume are compared with the reference deviations obtained for the same volume in absence of high Z material. A correlation between the actual data and reference data is calculated using Kolmogorov-Smirnov test, though other approaches may apply. The correlation is used for the decision making on the presence of a nuclear substance inside the volume.Type: ApplicationFiled: November 13, 2009Publication date: March 18, 2010Inventors: Jacques Goldberg, Isaac Shpantzer, Yaakov Achiam, Nadya Reingand
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Publication number: 20100060896Abstract: A method, device and computer program product for determining the material of an object based on its optical characteristics is disclosed. More specifically, the method operable on a touch screen that includes on its periphery a plurality of light sources (Li, i=1 to N) and sensors (Sj, j=1 to M), comprises the steps of transmitting a light from each of the light sources to an object within the boundary of the touch screen, determining a distance from the object to each of the light sources and each of the sensors, detecting the presences of the transmitted light at each of the sensors, determining, at each of the sensors a reflective index, n2 of the object and determining the object material based on the determined reflective indices.Type: ApplicationFiled: June 26, 2007Publication date: March 11, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: SANDER BERNARD FRANCIS VAN DE WIJDEVEN, TATIANA ALEKSANDROVNA LASHINA
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Publication number: 20100030488Abstract: A method is provided of calculating the structure of an inhomogeneous sample in which an electron beam is used to cause excitation of x-rays from the sample under known conditions of beam energy and geometry with respect to the sample. Notably the beam current is unknown. Measured x-ray intensity data for the sample corresponding to one or more sets of beam conditions and beam currents are firstly obtained, together with comparative x-ray intensity data for samples having known structures. A beam current factor for each beam condition is estimated and effective x-ray intensity data for each of the sets of conditions are then calculated using the measured and comparative x-ray intensity data and the beam current factor. The structure of the sample is then calculated for each of the sets of conditions using the effective x-ray intensity data. Predicting x-ray intensity data are produced corresponding to the calculated structure and compared with the effective x-ray intensity data.Type: ApplicationFiled: July 30, 2008Publication date: February 4, 2010Inventor: Peter John Statham
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Patent number: 7645984Abstract: Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix.Type: GrantFiled: February 11, 2005Date of Patent: January 12, 2010Assignee: Waters Technologies CorporationInventors: Marc V. Gorenstein, Robert S. Plumb, Chris L. Stumpf
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Publication number: 20090321653Abstract: Fissionable materials are distinguished from other high-effective atomic number materials by producing dual-energy x-ray radiation sufficient to cause fission in fissionable materials and directing the dual-energy x-ray radiation sufficient to cause fission in fissionable materials towards a physical region. X-ray radiation and a product of fission from the physical region are sensed. An absorption of the dual-energy x-ray radiation by the physical region is determined based on the sensed x-ray radiation, and whether the physical region includes fissionable material is determined based on the presence of a product of fission.Type: ApplicationFiled: April 17, 2009Publication date: December 31, 2009Applicant: L-3 Communications Security and Detection Systems, Inc.Inventors: David Perticone, Vitaliy Ziskin
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Publication number: 20090321313Abstract: A process and apparatus is disclosed for converting heavy hydrocarbon feed into lighter hydrocarbon products. The heavy hydrocarbon feed is slurried with a catalyst comprising iron oxide and alumina to form a heavy hydrocarbon slurry and hydrocracked to produce lighter hydrocarbons. The slurry hydrocracking reaction can be controlled by measuring the production of mesophase using X-ray diffraction. Upon a mesophase yield fraction reaching a predetermined level, reaction conditions should be moderated to avoid excessive coke production.Type: ApplicationFiled: June 30, 2008Publication date: December 31, 2009Inventors: Beckay J. Mezza, Alakananda Bhattacharyya, Andrzej Z. Ringwelski
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Patent number: 7638763Abstract: A method includes: accumulating ions having a plurality of m/z values in an ion trap during a time interval; deriving from the accumulated ions a respective intensity value for each of the m/z values; and adjusting each of the intensity values as a function of the time needed by the ion trap to begin collecting ions with the corresponding m/z value. According to a different aspect, an apparatus includes a first portion with an ion trap, and a second portion. The second portion causes the ion trap to accumulate ions with a plurality of m/z values during a time interval, derives from the accumulated ions in the ion trap a respective intensity value for each of the m/z values, and adjusts each of the intensity values as a function of the time needed by the ion trap to begin collecting ions with the corresponding m/z value.Type: GrantFiled: May 4, 2007Date of Patent: December 29, 2009Assignee: Thermo Finnigan LLCInventors: George B. Guckenberger, Scott T. Quarmby
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Patent number: 7635840Abstract: A surface analysis apparatus includes a unit configured to bombard a sample surface with at least two types of ions having different sizes; a measurement device for measuring, with a time-of-flight secondary ion mass spectrometer, a mass spectrum of ions emitted from the sample surface; and an information processor outputting a difference between two mass spectra measured by bombardment of different types of ions.Type: GrantFiled: June 26, 2007Date of Patent: December 22, 2009Assignee: Canon Kabushiki KaishaInventors: Kazuhiro Jindai, Hideto Yokoi
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Publication number: 20090299653Abstract: A method of characterising a sample from spectrometric data using calculation of spectral distance values is disclosed, for use in the field of mass spectrometry. Molecular formula assignment of peaks in mass spectral data is difficult and time-consuming, and the invention provides a computer implemented method of finding a most likely elemental composition of a measured spectral peak of interest. The method analyses isotopic peaks in a portion of the spectrum, using both their mass positions and intensities, to determine a spectral distance between those peaks and isotopic peaks of a candidate composition, finding peaks that match (140). A pattern spectral distance is determined (150) to provide a measure of the correspondence between a set of those peaks in the measured spectrum and peaks of each of a number of candidate compositions. The spectral fit is used to determine a most likely candidate composition.Type: ApplicationFiled: May 26, 2009Publication date: December 3, 2009Inventor: Hans PFAFF
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Patent number: 7627438Abstract: An observer based Q control method for a cantilever in an atomic force microscopy is provided that provides for a “dual” Q behavior such that a particular effective Q is achieved when a sample is present and another effective Q when a sample is absent. In the control method, the transfer function from dither input to photo-diode output is independent of the observer so that the cantilever effectively behaves like a spring-mass-damper system. The effective quality factor and stiffness of the cantilever can be changed by appropriately choosing the state feedback gain. The method provides sample-imaging using transient atomic force microscopy.Type: GrantFiled: April 27, 2007Date of Patent: December 1, 2009Assignee: Iowa State University Research Foundation, Inc.Inventors: Murti V. Salapaka, Deepak Ranjan Sahoo
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Publication number: 20090248322Abstract: Systems and methods for monitoring a sample or a sample flow associated with a process or an environment. The systems and methods transmit terahertz signals at the sample, receive a resulting spectral response, perform a spectral analysis, and display a result or choose a course of action. The analysis compares the sample's absorption or reflection spectral response to known spectrums to determine composition; or to determine if the sample flow has deviated from “normal”. In one embodiment, the systems and methods use reflection terahertz on a contained sample; in another it uses transmission terahertz to look at a sample flow outside the vehicle. In this embodiment the analysis is used to determine sample composition. In other embodiments, the analysis is used to discern or warn of changes, or to choose a course of action.Type: ApplicationFiled: March 28, 2008Publication date: October 1, 2009Applicant: The Boeing CompanyInventor: Charles W. Hlavaty
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Patent number: 7595485Abstract: In one aspect of the present invention, the less “useful” spectral data is disregarded from the spectral data resulting from the fragmentation by ETD and candidate charge states for the “useful” data assigned. Knowledge of the first order ion product charge state reduces the subset of comparison data hence aiding in the eventual identification of the precursor ion, and thus aiding in peptide sequence database searching capabilities. Such capabilities include, but are not limited to, computational requirements for database search and data storage, CPU time, the volume taken up on the hard disk to store results, visualization and dissemination of data, and overall improvement in the confidence in the precursor identification. Thus determination of the peptide sequence can be resolved in less time, costing less money, and requiring less computer power.Type: GrantFiled: February 7, 2007Date of Patent: September 29, 2009Assignee: Thermo Finnigan LLCInventors: Rovshan Goumbatoglu Sadygov, Andreas Huhmer
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Publication number: 20090228216Abstract: Methods, a processor, and a system for improving an accuracy of identification of a substance are described. One of the methods includes determining whether a relative molecular interference function of the substance includes at least one peak.Type: ApplicationFiled: March 7, 2008Publication date: September 10, 2009Inventor: Geoffrey Harding
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Patent number: 7583710Abstract: A laser and monitoring system is provided. In another aspect of the present invention, the system includes a laser, pulse shaper and detection device. A further aspect of the present invention employs a femtosecond laser and binary pulse shaping (BPS). Still another aspect of the present invention uses a laser beam pulse, a pulse shaper and a SHG crystal. In yet another aspect of the present invention, a multiphoton intrapulse interference phase scan (hereinafter “MIIPS”) method is used to characterize the spectral phase of femtosecond laser pulses and to correct them. A further aspect of the system of the present invention is employed to monitor environmental chemicals and biological agents, including toxins, explosives, and diseases.Type: GrantFiled: July 2, 2004Date of Patent: September 1, 2009Assignee: Board of Trustees operating Michigan State UniversityInventors: Marcos Dantus, Vadim V Lozovoy, Matthew Comstock
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Publication number: 20090216574Abstract: A monitoring system is disclosed for acquiring output activity, utilization capacity and/or effluent data from an facility on a facility-by-facility and/or an industry-by-industry basis. The system is designed to generate a plant and/or industry output activity database that is updated on a continuous, near continuous, periodic and/or intermittent basis so that subscribers are apprised of changes in plant or overall industry output. A clearing house is also disclosed for distributing the acquired data to subscribers to aid in analyzing, predicting trends, pricing, maintaining, adjusting, minimizing, and/or maximizing individual plant or overall industry output.Type: ApplicationFiled: August 17, 2006Publication date: August 27, 2009Inventors: Jack Nuszen, Thomas Vo
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Patent number: 7575932Abstract: The invention relates to a method for monitoring exothermic reactions in a reactor, in which one or more starting materials react exothermically to give at least one product, and at least one gas is present in the reactor during operation as intended or during a runaway, comprising the following process: A) measurement and storage of an initial temperature and an initial pressure in the reactor, B) calculation of the amount of products and starting materials present in the reactor from an energy balance, C) calculation of a maximum pressure raise that occurs on stepwise reaction of the amount of starting materials present, and D) calculation of a runaway pressure from the maximum pressure raise that occurs, calculated in step C), and the measured initial pressure stored in step A).Type: GrantFiled: June 6, 2003Date of Patent: August 18, 2009Assignee: BASF AktiengesellschaftInventors: Ulrich Nieken, Jobst Rüdiger von Watzdorf, Jochen Keβler, Christina Benthack, Hubertus Kröner, Thomas Hauff, Peter Schlemmer
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Patent number: 7567871Abstract: A system for performing spectral microanalysis delivers analysis results during the course of data collection. As spectra are collected from pixels on a specimen, the system periodically analyzes the spectra to statistically derive underlying spectra representing proposed specimen components, wherein the derived spectra combine in varying proportions to result (at least approximately) in the measured spectra at each pixel. Those pixels having the same dominant proposed component, and/or which contain at least approximately the same proportions of the proposed components, may then have their measured spectra combined (i.e., added or averaged). These spectra may then be cross-referenced via reference libraries to identify the components actually present.Type: GrantFiled: July 27, 2007Date of Patent: July 28, 2009Assignee: Thermo Electron Scientific Instruments LLCInventors: David B. Rohde, Patrick P. Camus
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Publication number: 20090182211Abstract: The present disclosure describes a method and an apparatus for analyzing measured signals using various processing techniques. In certain embodiments, the measured signals are physiological signals. In certain embodiments, the measurements relate to blood constituent measurements including blood oxygen saturation.Type: ApplicationFiled: March 24, 2009Publication date: July 16, 2009Applicant: MASIMO CORPORATIONInventors: Mohamed K. Diab, Esmaiel Kiani-Azarbayjany, Ibrahim M. Elfadel, Rex J. McCarthy, Walter M. Weber, Robert A. Smith
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Publication number: 20090168962Abstract: A system and methods for characterizing an unknown substance is described. One of the methods include determining an effective atomic number of the unknown substance as a first function of a first gradient of a first line.Type: ApplicationFiled: December 28, 2007Publication date: July 2, 2009Inventor: Geoffrey Harding
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Publication number: 20090171593Abstract: In one embodiment, the disclosure relates to a method for conducting a spectral library search to identify an un-known compound by acquiring one or more spectra of the compound; representing each spectrum as a target vector; providing an n-dimensional space having a plurality of partitioned spaces, at least one of the partitioned spaces containing at least one known vector representing a known material; mapping each target vector in one of the plurality of the partitioned spaces to form a mapped partitioned space; identifying one or more known vectors within the mapped partitioned space which approximate the target vector; and identifying the unknown compound by comparing the target vector to the known vectors within the mapped partitioned space which closely approximate the target vector.Type: ApplicationFiled: February 23, 2006Publication date: July 2, 2009Inventor: Robert Schweitzer
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Publication number: 20090132178Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.Type: ApplicationFiled: August 3, 2006Publication date: May 21, 2009Inventors: Akil I. Dharamsi, Megan Domagala, Teresa McGrath
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Patent number: 7533000Abstract: A method of analyzing a dataset of spectra is provided in which each spectrum has a count value for each of a number of parameter values within a parameter range. The method is for identifying one or more parameter values that exhibit a significant variation within the dataset. A dataset of spectra is obtained and a statistical analysis is applied to the count values for each of the parameter values. The result of the analysis for each parameter value is a function of the variation in the count values. A spectrum that is representative of at least part of the dataset of spectra is then displayed together with the results of the statistical analysis. A corresponding computer program and system for performing the method are also disclosed.Type: GrantFiled: July 28, 2006Date of Patent: May 12, 2009Assignee: Oxford Instruments Analytical LimitedInventors: Peter John Statham, Charles Penman
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Patent number: 7528373Abstract: A system for detection of gas leakage sources. An open-path FTIR detection system is located before the return filter of recirculating air of a factory to detect gas composition of recirculating air and transmits the result to a data server through a communication network. A multi-port extractive FTIR system is located in the factory to collect and detect gas sample of local area air using pipelines located in different areas and transmits the result of gas composition to the data server through the communication network. An IR monitor system obtains the gas composition from the data server through the communication network. A process exhaust management system obtains the gas composition from the IR monitor system through the communication network for the analysis of a gas leakage source.Type: GrantFiled: July 6, 2006Date of Patent: May 5, 2009Assignee: Industrial Technology Research InstituteInventors: Gen-Hou Leu, Shaw-Yi Yan, Hui-Ya Shih, Sheng-Jen Yu
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Publication number: 20090099962Abstract: A processor-performed method of facilitating the creation and sale of carbon credits. The method includes enrolling a plurality of carbon credits in a database. Each credit is associated with an account of a creator of the credit and with a project for generating the credit. The method includes determining whether one of the one or more projects is registered in a climate action registry; and, based on the determining, registering in the registry a validated credit associated with the registered project and including the registered credit in an account of an aggregator.Type: ApplicationFiled: October 15, 2007Publication date: April 16, 2009Inventors: Mark L. GREEN, Chris CARL
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Patent number: 7516031Abstract: A method of correcting for aberrations in scattering data is described which does not require prior knowledge about the sample microstructure properties or calculations based on the modelling of peak locations. In an example, X-ray scattering apparatus integrates a correction device arranged to automatically calculate and output aberration corrected output X-ray pattern using the aberration Fourier presentation Finst(H,2?) dependent from the scattering angle 2? and the Fourier transform of the measured X-ray scattering pattern Fexp(H).Type: GrantFiled: March 7, 2006Date of Patent: April 7, 2009Assignee: PANalytical B.V.Inventor: Vladimir Kogan