Abstract: A circuit for through silicon via (TSV) detection includes a TSV to be tested, an equivalent adjustable resistor and a reverse output circuit. A first terminal of the TSV to be tested is connected to a second terminal of the equivalent adjustable resistor, and a second terminal of the TSV to be tested is grounded. An input terminal of the reverse output circuit is connected to the first terminal of the TSV to be tested. The method includes: adjusting a resistance value of the equivalent adjustable resistor to a preset first resistance value, and keeping a voltage of a first terminal of the equivalent adjustable resistor at a preset voltage value, the first resistance value is a maximum resistance value of an equivalent resistor corresponding to the TSV to be tested when the TSV to be tested is normal.

Abstract: An exemplary system, method, and computer-accessible medium for generating diagnostic data associated with a likelihood a patient(s) developing a mental disease(s) can be provided, which can include, for example, providing a visual patterns to the patient(s), receiving electroencephalogram (EEG) information from the patient(s) that can be based on the visual pattern(s); and generating the diagnostic data based on the EEG information.

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

Abstract: Methods and systems of classification model evaluation are described. A processor may generate a classifier track comprising visual indicators representing the set of classifier labels. The classifier labels may be based on output data of a classification model. The processor may generate a label track comprising visual indicators representing a set of observed labels received from a device. The processor may output the classifier track and the label track on a user interface. The processor may receive a request to evaluate the classification model, where the request may indicate a performance metric. The processor may identify a set of operators associated with the performance metric. The processor may execute the identified set of operators on the classifier track and the label track. The processor may generate a performance track indicating the performance metric of the classification model. The processor may output the performance track on the user interface.

Abstract: A method and a sensor arrangement for determining a physical quantity are illustrated and described. The described method includes stimulating a capacitor device within a native component carrier; measuring a capacitance value of the capacitor device; and determining the physical quantity based on the measured capacitance value. Further described is a method for using a native component carrier as a transducer for detecting a value of a physical quantity.

Abstract: A method of operating a measurement instrument, such as a digital oscilloscope, includes receiving multiple analog input signals from a measurement target over respective channels, converting the analog input signal on each channel into a respective digital signal, and comparing signal values of the digital signal on each channel to at least one threshold to generate a stream of levels for each channel. The method includes combining the stream of levels for each channel into a combined stream of levels that reflects combined features of the multiple analog input signals, detecting a pattern in the combined stream of levels using a combined-feature matching procedure implemented by hardware, such as a Finite State Machine (FSM), and triggering the measurement instrument according to a result of the combined-feature matching procedure.

Abstract: An energy monitoring system includes a memory storing instructions to execute an energy modeling technique and processing circuitry for executing the instructions to operate the energy modeling technique. The energy modeling technique includes receiving energy data from a plurality of segments representative of one or more logical subgroups. The energy modeling technique includes categorizing the energy data of the logical subgroups into a plurality of segments. The energy modeling technique includes organizing the plurality of segments into a plurality of state-based hierarchical levels. The energy modeling technique includes calculating energy usage and factors associated with the plurality of state-based hierarchical levels via an energy model. The energy modeling technique includes outputting a visualization representative of the energy data corresponding to each of the segments to a monitoring and control system, resulting in a graphical representation accessible by a user-viewable screen.

Abstract: A method of minimizing cross-talk between optical modes propagating in a multi-mode optical fiber, comprises superimposing a plurality of optical wavefunctions; determining a relationship between superpositions of at least some of the optical wavefunctions and at least one measure of orthogonality of the optical modes at an output of the multi-mode optical fiber; and identifying a superposition of at least some of the optical wavefunctions that provides a desired or optimized value of the at least one measure of orthogonality using the determined relationship. The method further comprises generating, using light from a laser and at least one optical component, the identified superposition of at least some of the optical wavefunctions that provides the desired or optimized value of the at least one measure of orthogonality.

Abstract: The present disclosure provides method and a computer system for tracking audio streaming media. The method includes: after streaming media information matching a currently played audio stream segment is identified, determining whether the streaming media information matches a next audio stream segment, and when the streaming media information matches the next audio stream segment, directly returning a result; or when the streaming media information does not match the next audio stream segment, performing streaming media information matching again for the next audio stream segment, which occupies less memory, improves a calculation speed, and reduces calculation complexity of matching the streaming media information.

Abstract: A computing system may perform a method comprising displaying, on a graphical user interface (GUI) on a display of the computing system, a plurality of initial animations to a user, each of the plurality of animations being displayed in response to an identical function call, having an identical visual appearance, and being displayed to prompt an input from the user. The method may also comprise monitoring, by a processor of the computing system, the user's input to each of the plurality of animations. The method may also comprise displaying, by the GUI, a subsequent animation to the user, the subsequent animation being displayed in response to the identical function call but having a different visual appearance than the plurality of initial animations, the different visual appearance of the subsequent animation being based on the monitored inputs.

Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.

Abstract: Systems and methods are described herein for a variable-depth sonar. A null in the frequency response between a first and second operating frequency band is identified. A center operating frequency for each of the first and the second operating band is adjusted based on the ambient pressure. Furthermore, the velocity state of a vehicle may be calculated using periodic velocity updates. At least one transducer transmits a first signal in a first direction, and a Doppler sensor receives an echo of the first signal. The vehicle is turned in a second direction, and the at least one transducer transmits a second signal in the second direction. Using the first and the second velocity measurement, a vehicle velocity state is calculated.

Abstract: A touch circuit chip includes a load adjustment unit and a comparator. The load adjustment unit adjusts a determined impedance value according to an impedance matching signal. The first comparator has a first end electrically coupled to a first load and from which to receive a sensing signal, a second end electrically coupled to a second load via the load adjustment unit and from which to receive a reference signal, and an output end. The comparator compares the received sensing signal with the received reference signal and accordingly output a comparison result. The touch circuit chip determines whether there exists a change of a capacitance value of a coupling capacitor between the first and second loads according to the comparison result, wherein the determined impedance value is matched to the impedance value of the coupling capacitor and the first load. A touch apparatus is also provided.

Abstract: Disclosed is a microwave oven provided with: a heating chamber (2) for housing the object to be cooked therein; a magnetron (7) that oscillates by having a voltage applied thereto, and generates a microwave to be supplied to the heating chamber (2); a radio wave sensor (11) for detecting the microwave generated by the magnetron (7); a timer (15) for measuring an oscillation starting time that is a period of time from when the voltage is applied to the magnetron (7) to when the microwave is detected by the radio wave sensor (11) due to the oscillation; and a notification unit (6) for sending a notice about the timing at which the magnetron (7) should be exchanged. When the oscillation starting time becomes longer than a prescribed period of time, a notice about that fact is sent by the notification unit (6).

Abstract: A tension/speed measuring device comprises a laser driver for driving the oscillation of a semiconductor laser, and a counter for counting interference waveforms included in the output of a photodiode for converting the output of the semiconductor laser into an electrical signal. The counter measures the periods of interference waveforms during a measuring interval, where a frequency distribution for the periods of the interference waveforms during the measuring interval is generated from the measuring results, where a class value wherein the product of the class value and the frequency is a maximum is used as a representative value D0 at the periods of the interference waveform, to calculate a total Ns of the frequencies of the classes that are less than 0.5 times the representative value T0 and to calculate a total Nwn of the frequencies of the classes that are equal to or greater than (n+0.5) times the representative value T0 and less than (n+1.

Abstract: An apparatus and method for selecting a waveform for side-channel analysis are provided. The apparatus for selecting a waveform for side-channel analysis includes a matrix generation unit, a waveform transform unit, and a waveform selection unit. The matrix generation unit generates covariance matrices based on waveforms collected by a waveform collection apparatus. The waveform transform unit determines a 1st principal component using the generated covariance matrices, and to transform the waveforms using the determined 1st principal component. The waveform selection unit selects a waveform for the side-channel analysis from the transformed waveforms.

Abstract: A computer-implemented method, system, and/or computer program product monitors operational conditions of a cargo ship. A baseline composite vibration pattern is established from readings generated by multiple smart sensors. Each of the multiple smart sensors is a uniquely-identified smart sensor that has been affixed to one of multiple intermodal shipping containers that have been loaded onto a cargo ship, and each smart sensor includes a vibration sensor for detecting mechanical vibration. Subsequent readings are then taken from the multiple smart sensors to generate a new composite vibration pattern. In response to the new composite vibration pattern being different from the baseline composite vibration pattern, the new composite vibration pattern is matched with a known composite vibration pattern in order to identify a cause of the new composite vibration pattern.

Abstract: A distributed reflectometry device for diagnosing a network is disclosed. According to one aspect, the device includes at least one transmission line and several reflectometers connected to the network. A transmission portion of the device includes a first memory configured to store at least one test signal and a second memory configured to store weighting coefficients. The transmission portion may also include a first multiplier of a test signal (s) with a coefficient ?m, for producing a measurement m and a digital-to-analog converter connected to the line. A reception portion of the device includes an analog-to-digital converter configured to receive a signal from the line and provide a vector for the measurement m, a second multiplier of configured to multiply the vector with the coefficient ?m, an averaging module, and a post-processing and analysis module.

Abstract: The present invention is directed to an apparatus and method for remotely measuring surface air pressure. In one embodiment, the method of the present invention utilizes the steps of transmitting a signal having multiple frequencies into the atmosphere, measuring the transmitted/reflected signal to determine the relative received power level of each frequency and then determining the surface air pressure based upon the attenuation of the transmitted frequencies.

Abstract: A built-in self-test (BIST) circuit for detecting power supply droops is disclosed. In one embodiment, the BIST circuit includes a transition circuit configured to launch logical signals into a delay line. The BIST circuit also includes a comparator configured to compare a logic signal based on that input into the delay line with one output from the delay line. A mismatch resulting from the comparison is indicative of a power supply droop. The BIST circuit may also include circuitry for calibrating the delay line. The calibration may be performed by enabling a feedback path between the output of the delay line and its input. Enabling the feedback path may form a ring oscillator utilizing the delay line. A counter may count the number of transitions caused by the ring oscillator in a predetermined time. The resulting count may be used to determine if the delay is in a desired range.

Abstract: Disclosed is a probe for an oscilloscope comprising a multi-stage transistor amplifier that acts as an impedance transformer. Said amplifier is a d.c.-coupled emitter follower circuit that is composed of bipolar transistors or a d.c.-coupled source follower circuit which is composed of field effect transistors and the successive amplifier elements of which are dimensioned and tuned to each other in such a way that the resulting offset direct voltage between the input and the output is minimal.

Abstract: A movement detection system is provided with a wireless terminal, and a movement detection device connectable to the wireless terminal via a wireless network such that the wireless terminal receives signals used for detection at a predetermined frequency from the movement detection device, and transmits verification signals in response to each of the detection signals. The movement detection device includes a measurement portion that measures the signal strength of the verification signals transmitted by the wireless terminal, and a detection portion that detects spatial movement of the wireless terminal based on the signal strength of the verification signals measured by the measurement portion.

Abstract: A method and system for using Equivalent Time Sampling to improve the effective sampling rate of sensor data, and using the improved-resolution data for diagnosis and control. Data samples from existing sensors are provided, where the sampling rate of the existing sensors is not sufficient to accurately characterize the parameters being measured. High-resolution data sets are reconstructed using Equivalent Time Sampling. High-resolution input data sets are used in a system model to simulate the performance of the system being measured. Results from the system model, and high-resolution output data sets from Equivalent Time Sampling, are provided to an estimator, which provides accurate estimation of measured quantities and estimation of quantities not measured. Output from the estimator is used for fault diagnosis and control of the system being measured.

Abstract: A method and system for detecting anomalies in an aeroengine. The method and system define a behavior model of a controller of the aeroengine using a time regression modeling the behavior of the controller as a function of a data set relating to the controller and including measurements of past behaviors and command and state measurements of the controller; continuously recalculate the behavior model for each new data set; and monitor statistical variation of the behavior model to detect a behavior anomaly of the controller representing an operating anomaly of the engine.

Abstract: A method for operating a data processing system to generate a test for a device under test (DUT) is disclosed. The method utilizes a model of the DUT that includes a plurality of blocks connected by wires and a set of control inputs. Each block includes a plurality of ports, each port being either active or inactive. Each block is also characterized by a set of constraints that limit which ports are active. The active ports of at least one of the blocks are constrained by one of the control inputs. A test vector having one component for each port of each block and one component for each control input is determined such that each set of constraints for each block is satisfied. The test vector defines a test for the DUT.

Abstract: In a method for measuring a scattering medium, pulse light with a predetermined wavelength is made incident on a scattering medium which is a measurement object and a scattering medium for reference, the pulse light transmitted inside the scattering media is detected to acquire a light detection signal, the measurement waveform is acquired on the basis of the detected light detection signal, a parameter of a function showing the theoretical waveform of the measurement object is specified in such a manner that the result of convolution operation on the theoretical waveform of the measurement object and the measurement waveform of the reference is made equal to the result of convolution operation on the theoretical waveform of the reference and the measurement waveform of the measurement object, and calculation is made for the internal information of the scattering medium on the basis of the theoretical waveform shown by the function.

Abstract: A method for analyzing the output of a rotary sensor, such as that coupled to a vehicle wheel assembly. In one embodiment, the method detects periodic irregularities in the output of an incremental rotary sensor and uses those irregularities with a reference signal and a pattern comparison technique to determine the absolute angular position of the sensor.

Abstract: A method of estimation of a location of a terminal within an area of coverage of a wireless network comprising at least one fixed node. The method comprises estimating the location of the terminal on the basis of at least a comparison between data representing a first metric of a complex frequency response of a radio channel between the terminal and one of the at least one fixed node and data representing a plurality of stored metrics. Each of the plurality of stored metrics being related to one of a plurality of different locations within the network and each stored metric being of a complex frequency response measured between the one of the fixed nodes and the location within the network to which the metric relates.

Abstract: Embodiments of a method and apparatus for variable sensing using the frequency domain are taught herein. An exposure of a system to a physical variable is determined by periodically sensing the physical variable to produce a plurality of digital samples. The plurality of digital samples is converted to respective frequency domain representations. The exposure is calculated using the frequency domain representations.

Abstract: A correlation system, such as a correlation optical time domain reflectometer (OTDR) system, transmits a correlation sequence, such as an M-sequence, and measures the returns of the correlation sequence over time. The system correlates the transmitted sequence with the returns to provide correlation measurement values that respectively correspond to different distances from the point of transmission. A correlation error compensation element adjusts each correlation measurement value in order to cancel the contribution of the correlation error floor from the measurements to provide compensated measurement values that are substantially free of the effects of the correlation error floor.

Abstract: A motion sensor has a state processor to identify states associated with a magnetic field signal provided by a magnetic field sensing element. The state processor includes a state peak logic module configured to generate states that have a reduced amount of state chatter.

Abstract: To provide a signal generator, a signal generating system, and a signal generating method capable of repeatedly generating an arbitrary waveform and making the phases of the head and tail of the generated waveform continuous with each other, without changing the frequency of the waveform. A signal generator (10, 11, 12) includes phase shift means (30) that receives waveform data which is repeatedly output n times, shifts the phase of each sample data item in an n-th waveform data item by a phase shift amount ?n corresponding to the number of times n the waveform data is repeatedly output, and outputs the waveform data to D/A conversion means.

Abstract: Described herein is the method and apparatus for determining frequency of an oscillator coupled with one or more analog devices, and for determining within-die or across-die variations in an analog property associated with the one or more analog devices, the determining based on the oscillator frequency. The analog property includes output signal swing, bandwidth, offset, gain, and delay line linearity and range. The one or more analog devices include input-output (I/O) buffer, analog amplifier, and delay line. The method further comprises updating a simulation model file based on the determining of the within-die and/or across-die variations of the analog property.

Abstract: A method of optimising at least one measure that is a quadratic function of a wavefunction, such as the spot size of a laser, the method comprising: superimposing a plurality of wavefunctions; determining a relationship between the superimposed wavefunctions and the quadratic measure, and using the determined relationship to identify the superimposed wavefunctions that provide a desired or optimised quadratic measure.

Abstract: A blade monitoring system for calculating average threshold crossings from interpolated threshold crossings of digital waveform samples is disclosed. Each digital waveform sample is converted by an analog-to-digital converter from one of two split analog signals. Each split analog signal is received from a signal splitter that receives each analog signal from an analog signal transmitter. Each analog signal is from a sensed blade passing signal from at least one row of a plurality of blades on a compressor of a turbine.

Abstract: The apparatus corrects multi-phase signals for detecting a position of an object and obtains a phase corresponding to the position of the object. The apparatus includes a correcting unit correcting the multi-phase signals with error coefficients, respectively, a phase calculating unit performing calculation for the corrected multi-phase signals to obtain the phase, a regression unit performing regression for the calculated phases to obtain reference phases, a Fourier transform unit respectively performing Fourier transform for the corrected multi-phase signals whose phases having been respectively changed into the reference phases, and an updating unit updating, using Fourier coefficients obtained by the Fourier transform unit, the error coefficients respectively corresponding to the Fourier coefficients. The updating unit updates the error coefficients if a regression error in the regression performed by the regression unit satisfies a predetermined condition.

Abstract: The present invention relates to a machine implemented method for spectral analysis that determines a measure of cross coherence between application of two spectral estimation filters to data; and identifies a spectral feature of the measure of cross coherence. One example embodiment of the present invention provides a complete statistical summary of the joint dependence of the Bartlett and Capon power spectral statistics, showing that the coupling is expressible via a 2×2 complex Wishart matrix, where the degree coupling is determined by a single measure of cross coherence defined herein. This measure of coherence leads to a new two-dimensional algorithm capable of yielding significantly better resolution than the Capon algorithm, often commensurate with but at times exceeding finite sample based MUSIC.

Abstract: A vibration-type measuring device includes an exciter arrangement which exerts a time-dependent force with at least one sinusoidal component at an adjustable excitation frequency on a measuring tube, through which a medium can flow, and causes the measuring tube to oscillate. The measuring device includes first and second sensors which are fitted to the measuring tube at different locations. The first and second sensors output first and second measurement signals, respectively. The measuring device includes an evaluation unit which determines a first phase shift between the first and second measurement signals and uses the determined phase shift to determine a measurement variable of the medium. The measuring device includes a phase comparator, which determines a second phase shift between the force and the average value of the first and second measurement signals, and a frequency generator which sets the excitation frequency on the basis of the second phase shift.

Abstract: The location of a terminal is estimated within an area of coverage of a wireless network comprising at least one fixed node by measuring a complex frequency response of a radio channel between the terminal and one of said fixed nodes and estimating the location of the terminal on the basis of at least a comparison between data representing a first metric of the measured complex frequency response and data representing a plurality of stored metrics, each of said plurality of stored metrics being related to one of a plurality of different locations within the network and each stored metric being of a complex frequency response measured between the said one of said fixed nodes and the location within the network to which the metric relates.

Abstract: A technique detects an abnormal signal in a compound sampled signal recorded in the time domain. The technique involves dividing the sampled signal recorded in the time domain into sample segments; transforming each of the sample segments from the time domain into the frequency domain to determine transformed segments, each transformed segment having frequency points, each frequency point having an amplitude associated with a certain frequency; for a frequency point in a given transformed segment, determining a ratio by dividing the amplitude of the frequency point by a value indicative of an average of the amplitudes of the frequency points at the same frequency across transformed segments; repeating the determination of a ratio for frequency points in each transformed segment to determine ratios for each transformed segment; repeating the determination of ratios for transformed segments; and using the ratios to detect the abnormal signal in the compound sampled signal.

Abstract: A method and system for incorporating electronic signature analysis in a low voltage power supply to centrally monitor current consumption is disclosed. The electrical loads powered by the low voltage power supply can be tested individually via an automatic test routine by measuring and scaling of current through a differential amplifier. The current consumption of each electrical load can be measured by analyzing a “delta” in the current draw of each electrical load's ON and OFF condition. This value can be compared against a stored table of high and low limits for each electrical load. If a load's current is outside the limits, it will be logged for repairs. A current sensing device can be inserted in series with the output(s) of the low voltage power supply, while in test mode, to allow the automatic test routine to run, and then be shorted out for normal operation.

Abstract: A method for the calibration or diagnosis of a motor vehicle brake system having a cyclically operated pump. At least one parameter (URPOff), representing the electromotor force of the reference pump, is repeatedly ascertained during operation of a reference pump under defined guidelines. A statistical characteristic variable (URPOff) is derived from the values of parameter (URPOff) ascertained for the reference pump. Parameter (UBPOff) is ascertained under a corresponding guideline during operation of an operating pump. Corresponding statistical characteristic variable (UBPOff) is derived from the values of parameter (UBPOff) ascertained for the operating pump. At least one ratio number is calculated as a measure of the deviation of the operating behavior of the operating pump from the operating behavior of the reference pump from the characteristic variable (URPOff) calculated for the reference pump and the characteristic variable (UBPOff) calculated for the operating pump.

Abstract: An apparatus includes a test signal generation unit supplying test signals to an orthogonal modulator and a control unit that based on a result of decision by comparison and decision of detection results of a detector detecting envelopes of modulated signals output from the orthogonal modulator responsive to the test signals, derives adjustment values and a compensation value. An estimation means estimates a DC offset and an IQ mismatch of the orthogonal modulator, based on the derived compensation value. The test signals includes a first set including a first test signal (I1, Q1) and a second test signal (I2, Q2) having a predetermined relationship with the first test signal, and a second set of which in-phase and quadrature components have predetermined relationships respectively with in-phase and quadrature components of the first set.

Abstract: Faults resulting in reception of a still, but unknown, frame are recognized by comparing each received frame of the video signal with its predecessor, incrementing a counter in the event that the difference between the frames falls below a threshold; and generating an alarm signal in the event that the count of the counter exceeds a predetermined count. Other types of fault such as loss of signal (i.e. reception of just noise) are recognized by incrementing the counter whenever the difference exceeds a threshold. Similar results may be obtained by instead the monitoring quantization step size and/or number of transmitted bits of a digitally coded signal, and noting that it falls below, or exceeds, a threshold. A preferred option is to compute a complexity measure, being a monotonically increasing function (e.g the product) of the quantization step size and of the number of coded bits and compare this with the threshold value.

Abstract: An apparatus for determining information in order to temporally align first and second information signals, each including one or several information values for successive sampling times, the apparatus including a characteristic extractor for extracting a characteristic per sampling time or per subsequence of sampling times from the first information signal within a first search pattern to obtain a first characteristic curve, and for extracting the characteristic per sampling time or per subsequence of sampling times from the second information signal within a second search pattern to obtain a second characteristic curve and a determiner for determining the information for temporal alignment based on similarities between the first and second characteristic curves of the characteristic by means of a first search for a search pattern from one of the first and second characteristic curves of the characteristic within the other of the first and second characteristic curves of the characteristic.

Abstract: A monitoring method for Through-Silicon Vias (TSVs) of a three-dimensional integrated circuit (3D IC) is provided, wherein the 3D IC includes a plurality of TSVs, and the method includes: providing a plurality of inverters; connecting the inverters with the TSVs as a circuit; enabling the circuit to oscillate; measuring an output signal on an output end of one of the inverters; and determining the characteristic of TSVs of the 3D IC based on the output signal.

Abstract: The invention concerns a method capable of discriminating between a gamma component and neutron component in an electronic signal (S1) resulting from the detection of gamma and/or neutron radiation, characterized in that it comprises the following steps: delaying by a time TAU and attenuating by a coefficient ALPHA the signal (S1), to obtain a delayed and attenuated signal (S2), subtracting the delayed and attenuated signal (S2) from the electronic signal (S1) to obtain a difference signal (S3) which comprises a gamma component and/or neutron component, and computing a magnitude sigma1 such that: sigma ? ? 1 = ? ? T ? ? 2 ? S 3 ? ( t ) ? ? ? t where ? is an instant when the gamma component passes zero and T2 is a previously determined instant later than instant ? chosen so that, in an interval [?ref, T2], the magnitude sigma1 is negative for a gamma component and positive for a neutron component.

Abstract: A device for triggering a recording of a measured signal dependent upon at least one triggering event identifiable in a occurrence distribution of parameter pairs from two mutually-dependent parameters of the measured signal includes a discriminator for the identification of triggering events in each case with one frequency (NofTreffer) determined for the respective parameter pair and, in a first embodiment, disposed outside, and in a second embodiment, disposed inside, an upper and lower threshold value (UpperNofTreffer, LowerNofTreffer) associated with the respective parameter pair and for marking each occurring triggering event with the assistance of an activated first trigger marker (TrigMerk1) associated with the respective parameter pair. A memory is used for buffering at least the upper and lower threshold value (UpperNofTreffer, LowerNofTreffer) for every parameter pair.

Abstract: Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated. By counting the number of sequence tags mapped to a predefined window in each chromosome, the over- or under-representation of any chromosome in maternal plasma DNA contributed by an aneuploid fetus can be detected. This method does not require the differentiation of fetal versus maternal DNA. The median count of autosomal values is used as a normalization constant to account for differences in total number of sequence tags is used for comparison between samples and between chromosomes.

Abstract: Differences in outputs from multiple terminals are easily measured.