Biological Or Biochemical Patents (Class 703/11)
  • Patent number: 9443343
    Abstract: Provided is a method and apparatus for realistically reproducing an eyeball that may verify and analyze a material property and a deformation property with respect to each of constituent portions of an eyeball and may render each of the constituent portions based on the analyzed priorities, thereby more realistically reproducing the eyeball.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: September 13, 2016
    Assignees: Samsung Electronics Co., Ltd., University of Southern California
    Inventors: Tae Hyun Rhee, Seon Min Rhee, Hyun Jung Shim, Do Kyoon Kim, Abhijeet Ghosh, Jay Busch, Jen-Yuan Chiang, Paul Debevec
  • Patent number: 9424337
    Abstract: A method of determining a number of clusters for a dataset is provided. Centroid locations for a defined number of clusters are determined using a clustering algorithm. Boundaries for each of the defined clusters are defined. A reference distribution that includes a plurality of data points is created. The plurality of data points are within the defined boundary of at least one cluster of the defined clusters. Second centroid locations for the defined number of clusters are determined using the clustering algorithm and the reference distribution. A gap statistic for the defined number of clusters based on a comparison between a first residual sum of squares and a second residual sum of squares is computed. The processing is repeated for a next number of clusters to create. An estimated best number of clusters for the received data is determined by comparing the gap statistic computed for each iteration of the number of clusters.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: August 23, 2016
    Assignee: SAS Institute Inc.
    Inventors: Patrick Hall, Ilknur Kaynar Kabul, Warren Sarle, Jorge Silva
  • Patent number: 9424761
    Abstract: Simulation systems and methods may enable medical training. A manufacturing unit may receive data from a configuration unit indicating identification and manufacturing parameters for an anatomy model. A data processing unit may receive data from the configuration unit identifying the anatomy model, and data from a calibration unit indicating a position and/or orientation of a position and orientation sensor relative to the anatomy model. The data processing unit may also receive data from the position and orientation sensor indicating a position and/or orientation of the anatomy model. The data processing unit may generate a virtual image using the data from the position and orientation sensor, the data from the calibration unit, and the data from the configuration unit. The data processing unit may render the virtual image to a display.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: August 23, 2016
    Assignee: VIRTAMED AG
    Inventors: Stefan Tuchschmid, Carolyn O'Brien, Daniel Bachofen, Matthias Harders, Jonas Spillmann
  • Patent number: 9390232
    Abstract: Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: July 12, 2016
    Assignee: HeartFlow, Inc.
    Inventors: Charles A. Taylor, Hyun Jin Kim, Sethuraman Sankaran, Michiel Schaap, David Eberle, Gilwoo Choi, Leo Grady
  • Patent number: 9373486
    Abstract: Systems and methods are provided for species detection using mass spectrometry. In various embodiments, a multiple reaction monitoring (MRM) experiment is performed on a sample targeting one or more peptide transitions that are unique to one or more species using a tandem mass spectrometer. One or more measured product ion spectra are received from the tandem mass spectrometer using the processor. The one or more measured product ion spectra are compared to product ions of the one or more peptide transitions that are unique to one or more species using the processor. One or more species of the sample are detected by reporting product ions of the one or more peptide transitions that are unique to one or more species that match the one or more measured product ion spectra using the processor.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: June 21, 2016
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Stephen Lock
  • Patent number: 9349178
    Abstract: In hemodynamic determination in medical imaging, the classifier is trained from synthetic data rather than relying on training data from other patients. A computer model (in silico) may be perturbed in many different ways to generate many different examples. The flow is calculated for each resulting example. A bench model (in vitro) may similarly be altered in many different ways. The flow is measured for each resulting example. The machine-learnt classifier uses features from medical scan data for a particular patient to estimate the blood flow based on mapping of features to flow learned from the synthetic data. Perturbations or alterations may account for therapy so that the machine-trained classifier may estimate the results of therapeutically altering a patient-specific input feature. Uncertainty may be handled by training the classifier to predict a distribution of possibilities given uncertain input distribution.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: May 24, 2016
    Assignee: Siemens Aktiengesellschaft
    Inventors: Lucian Mihai Itu, Tiziano Passerini, Saikiran Rapaka, Puneet Sharma, Chris Schwemmer, Max Schoebinger, Thomas Redel, Dorin Comaniciu
  • Patent number: 9299145
    Abstract: Systems and articles of manufacture for image segmentation are provided herein, and include creating an anatomical model from training data comprising one or more imaging modalities, generating one or more simulated images in a target modality based on the anatomical model and one or more principles of physics pertaining to image contrast generation, and comparing the one or more simulated images to an unlabeled input image of a given imaging modality to determine a simulated image of the one or more simulated images to represent the unlabeled input image.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: March 29, 2016
    Assignee: International Business Machines Corporation
    Inventors: Noel C. Codella, John R. Smith
  • Patent number: 9240062
    Abstract: A node arranging apparatus includes: a node arranging unit that arranges, in a virtual three-dimensional space, nodes indicated by inter-node information stored in an inter-node information storage unit; a node moving unit that moves each node using a movement amount and a movement direction of that node determined by arrangement relationship of that node with a first plane, arrangement relationship with another node arranged in the virtual three-dimensional space, and arrangement relationship with at least one other node associated therewith by the inter-node information and arranged in the virtual three-dimensional space; a display information generating unit that generates display information of a node connection image where nodes are projected and connected; and an output unit that outputs the display information. The node moving unit repeatedly performs at least once the node moving process until a predesignated condition is satisfied.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: January 19, 2016
    Assignee: SOFTWARE CRADLE CO., LTD.
    Inventor: Hiroshi Morikawa
  • Patent number: 9220572
    Abstract: A method of implanting a hip joint prosthesis into a patient can include obtaining image data of hip joint anatomy of the patient. Physical activities that the patient desires to participate in subsequent to implanting the hip prosthesis can be determined. A size and an initial placement of the hip joint prosthesis based on the image data can be determined. A desired range of motion of the hip joint prosthesis based on the determined physical activities can be determined. A plan can be created comprising a desired implanted location of the hip joint prosthesis and based on the desired range of motion. The plan can be incorporated onto a guide. The plan can be executed with the guide thereby implanting the hip joint prosthesis into the patient at the desired implanted position.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: December 29, 2015
    Assignee: Biomet Manufacturing, LLC
    Inventors: Jason Meridew, William Jason Slone, Mark Scrafton, John White, Seth Nash
  • Patent number: 9215988
    Abstract: A cardiac signal generator includes a portable housing, a memory, a processing device, a digital to analog converter, and at least one analog output. The memory stores programming instructions including instructions defining a plurality of mathematical relationships. The processing device is configured to execute the programming instructions to generate a sequence of output values using the plurality of mathematic relationships as a function of time, wherein the sequence of output values defines a sampled waveform output simulating an ECG signal and having linear portions and at least one curved portion. The processing device furthermore provides the sequence of output values at an output. The digital to analog converter is operably coupled to receive the sequence of output values from the output, and generates an electrical signal having a waveform corresponding to the sampled waveform output. The analog output is operably coupled to the digital to analog converter.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: December 22, 2015
    Assignee: Medxcel, LLC
    Inventors: Robert Cadick, Dax Hafer
  • Patent number: 9218745
    Abstract: A system for neuromuscular training via a communication network, including a computer processor connectable to the communication network, the processor capable of performing operations including: retrieving data representative of a training scenario from a database in response to a user selection on an input device, generating test elements, parameters and controls based on the retrieved data, monitoring use of the input device by the user, performing calculations of a simulated environment in response to the use of the input device by the user and the test elements, parameters and controls, generating real time images replicating the simulated environment of management of the test elements by the user and recording results of the simulation in the database.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 22, 2015
    Assignee: 123 CERTIFICATION INC.
    Inventor: Claude Choquet
  • Patent number: 9202010
    Abstract: Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: December 1, 2015
    Assignee: HeartFlow, Inc.
    Inventors: Charles A. Taylor, Hyun Jin Kim, Sethuraman Sankaran, Michiel Schaap, David Eberle, Gilwoo Choi, Leo Grady
  • Patent number: 9189747
    Abstract: Methods, systems, and apparatus, including computer programs encoded on one or more computer storage devices, for training a predictive model. In one aspect, a method includes receiving over a network predictive modeling training data from a client computing system. The training data and multiple training functions obtained from a repository of training functions are used to train multiple predictive models. A score is generated for each of the trained predictive models, where each score represents an estimation of the effectiveness of the respective trained predictive model. A first trained predictive model is selected from among the trained predictive models based on the generated scores. Access to the first trained predictive model is provided over the network.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: November 17, 2015
    Assignee: Google Inc.
    Inventors: Gideon S. Mann, Jordan M. Breckenridge, Wei-Hao Lin
  • Patent number: 9173574
    Abstract: A probabilistic data signal processor used to determine health of a system is described. Initial probability distribution functions are input to a dynamic state-space model, which iteratively operates on probability distribution functions, such as state and model probability distribution functions, to generate a prior probability distribution function, which is input to a probabilistic updater. The probabilistic updater integrates sensor data with the prior to generate a posterior probability distribution function passed to a probabilistic sampler, which estimates one or more parameters using the posterior, which is output or re-sampled and used as an input to the dynamic state-space model in the iterative algorithm. In various embodiments, the probabilistic data signal processor is used to filter output from any mechanical device using appropriate physical models, which optionally include chemical, electrical, optical, mechanical, or fluid based models.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: November 3, 2015
    Inventors: Rodrigo E. Teixeira, Alton Reich
  • Patent number: 9136939
    Abstract: A handheld diabetes manager is presented with an improved graphical user interface for a bolus calculator. The bolus calculator is configured to receive blood glucose measurements from a blood glucose measurement module and operates, in response to an input, to compute an insulin recommendation for a patient based in part on the blood glucose measurements. The graphical user interface for the bolus calculator includes a health adjustment screen that enables a user to input a value for health events associated with the insulin recommendation, where the input value represents a cumulative effect of the health events on insulin of the patient and the health adjustment screen presents a different icon for each of the health events associated with the insulin recommendation.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: September 15, 2015
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Paul J. Galley, Mark G. Mears, Phillip E. Pash, Vincent R. Rizzo, Bettina Steiner, Kristin M. Westerfield, Richard W. Wilson
  • Patent number: 9135381
    Abstract: A computer-implemented method for simulating blood flow through a heart valve may first involve receiving patient-specific data, including imaging data related to the heart valve, an inflow tract of the heart valve and an outflow tract of the heart valve, and at least one clinically measured flow parameter. Next, the method may involve generating a digital model of the heart valve and the inflow and outflow tracts, based at least partially on the imaging data, discretizing the model, applying boundary conditions to a portion of the digital model that contains the heart valve and the inflow and outflow tracts, and initializing and solving mathematical equations of blood flow through the model to generate computerized flow parameters. Finally, the method may involve comparing the computerized flow parameters with the at least one clinically measured flow parameter.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: September 15, 2015
    Assignee: STENOMICS, INC.
    Inventor: Michael A. Singer
  • Patent number: 9121847
    Abstract: Provided are methods and devices for formation and study of three-dimensional biological systems, including prokaryotic and eukaryotic cell migration, proliferation, and differentiation.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: September 1, 2015
    Assignee: Massachussetts Institute of Technology
    Inventors: Roger D. Kamm, Seok Chung, Vernella V. Vickerman-Kelley
  • Patent number: 9047025
    Abstract: A system for print service provider (PSP) operations management includes a provenance analytics engine. The provenance analytics engine accesses fresh meta-data associated with fresh events in a PSP operation performed using a printing system operated by a PSP. The provenance analytics engine further accesses stored meta-data associated with past events related to past PSP operations. Still further, the provenance analytics engine accesses a component behavioral model (CBM) to produce results associated with events in a PSP operation. The provenance analytics engine analyzes the event-related meta-data.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: June 2, 2015
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Jun Zeng, Eric Hoarau, I-Jong Lin
  • Patent number: 9043190
    Abstract: Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising acquiring an anatomical model of at least part of the patient's vascular system; performing, using a processor, one or more of geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical model; and identifying, using the processor, a personalized cardiovascular device for the patient, based on results of one or more of the geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of anatomical model.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: May 26, 2015
    Assignee: HeartFlow, Inc.
    Inventors: Leo Grady, Charles A. Taylor, Gilwoo Choi, Campbell Rogers
  • Patent number: 9039612
    Abstract: A coiling parameterization tool includes a processor and a display for displaying values of lumen volume, packing and coiling parameters for filling a lumen in relation to a desired packing. The processor is configured to detect a change in one of the displayed values and, in response to the change, to automatically evaluate, change and display remaining values displayed on the display.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: May 26, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Pieter Maria Mielekamp, Drazenko Babic
  • Patent number: 9043157
    Abstract: A device for the collection and processing of information relating to the exposure of one or more persons to one or more products of chemical or biological origin has: at least one coded sensor for automatic or semi-automatic identification of a person likely to be exposed to at least one product, at least one coded sensor for the collection of information relating to the handling of at least one product by the person likely to be exposed to the product, at least one sensor for validating the information collected by the identification and collection sensors, at least one module for reading at least one coded sensor, and a module for processing information collected by the sensors.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: May 26, 2015
    Assignee: BIOGEMMA
    Inventors: Didier Hatsch, Pascual Perez
  • Patent number: 9043191
    Abstract: Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising: generating a patient specific model of at least a portion of a patient's vasculature from image data of the patient's vasculature and one or more measured or estimated physiological or phenotypic parameters of the patient; determining pathology characteristics from cardiovascular geometry of the patient specific model; defining an objective function for a device based on design considerations and one or more estimates of hemodynamic and mechanical characteristics; optimizing the objective function, by simulating at least one change in devices and evaluating the objective function using fluid dynamic or structural mechanic analysis; and using the optimized objective function to either (i) select a device from a set of available devices or (ii) manufacture a desired device.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: May 26, 2015
    Assignee: HeartFlow, Inc.
    Inventors: Leo Grady, Charles A. Taylor, Gilwoo Choi, Campbell Rogers
  • Publication number: 20150142408
    Abstract: Some embodiments include a computer-assisted method of biomedical treatment design. For example, a computer system can select a compound model associated with a candidate compound that is structured to bind to a biological target to modulate the biological target into achieving a therapeutic effect. The computer system can then identify a structural feature in the compound model as a hinge region that connects domains in the candidate compound. The computer system then determines a mutation process to introduce a mutation at the hinge region such that the mutation activates the candidate compound. The computer system then generates an updated compound model based on the mutation added to the candidate compound to present in a treatment design interface.
    Type: Application
    Filed: November 17, 2014
    Publication date: May 21, 2015
    Inventor: Akiko Futamura
  • Patent number: 9037445
    Abstract: Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium; calculating metabolic flux reorganization in various environments and at various growth rates; and calculating the maximum metabolic rate and optimal metabolite concentrations and enzyme activities by applying a computational optimization method to a kinetic model of a metabolic pathway. The optimization methods use intracellular molecular crowding parameters and/or well as kinetic rates to assist in modeling metabolic activity.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: May 19, 2015
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Zoltan N. Oltvai, Alexei Vazquez
  • Publication number: 20150134316
    Abstract: Treatment validation techniques include generating a modified treatment target from an original treatment target using a modification process, and comparing induced aberrations provided by the original and modified treatment targets, so as to verify the modified treatment target or the modification process. In some cases, a modification process may include a deconvolution process, a low pass filter process, a scaling process, or an adjustment process. The induced aberrations may include high order aberrations, such as spherical aberration.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 14, 2015
    Inventors: Guang-ming Dai, Anatoly Fabrikant, Dimitri Chernyak, Jayesh Shah
  • Publication number: 20150131866
    Abstract: The invention is a method using a computer to construct a grid representative of the distribution of a physical property of an underground formation having application to petroleum reservoir development. A set of initial grid cells MI containing at least one conditioning point PC is defined. Each cell MI is then visited and assigned a value representative of the property using a filling method. At least one unvisited cell (MNV1, MNV2) adjacent to at least one already visited cell MV is then identified, and the number N of adjacent cells MV is determined for each cell (MNV1, MNV2). Each cell (MNV1, MNV2) is then visited and filled according to the decreasing values of N. The stages of identification and filling of cells (MNV1, MNV2) are repeated until each cell of the grid has been visited.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 14, 2015
    Inventor: Mickaele LE RAVALEC
  • Publication number: 20150134315
    Abstract: Disclosed are methods for building a sequence activity model with reference to structural data, which model can be used to guide directed evolution of proteins having beneficial properties. Some embodiments use genetic algorithms and structural data to filter out uninformative data. Some embodiments use a support vector machine to train the sequence activity model. The filtering and training methods can generate a sequence activity model having higher predictive power than conventional modeling methods. Systems and computer program products implementing the methods are also provided.
    Type: Application
    Filed: September 26, 2014
    Publication date: May 14, 2015
    Inventors: Russell Javiniar Sarmiento, Donald Scott Baskerville, Xiyun Zhang
  • Publication number: 20150127317
    Abstract: The present invention provides an integrated model of metabolic and macromolecular expression (ME-Model), and a method for reconstructing an ME-Model from biological data. Specifically, the present invention provides a ME-Model which uses a biochemical knowledgebase of an organism to accurately determine the metabolic and macromolecular phenotype of the organism under different conditions. Further, the present invention provides a method to determine the most efficient conditions for producing a product from an organism.
    Type: Application
    Filed: May 9, 2013
    Publication date: May 7, 2015
    Inventors: Daniel R. Hyduke, Joshua A. Lerman, Bernhard O. Palsson, Edward O'Brien
  • Publication number: 20150127316
    Abstract: A system and method for converting static/still medical images of a particular patient into dynamic and interactive images interacting with medical tools including medical devices by coupling a model of tissue dynamics and tool characteristics to the patient specific imagery for simulating a medical procedure in an accurate and dynamic manner by coupling a model of tissue dynamics to patient specific imagery for simulating cerebral aneurysm clipping surgery.
    Type: Application
    Filed: March 30, 2012
    Publication date: May 7, 2015
    Inventor: Mordechai Avisar
  • Publication number: 20150120265
    Abstract: The present invention disclose a computerized system for designing nucleic acid sequences for gene expression comprising; (a) a server [103] for hosting a database [106] (b) a network connection [102] and (c) a computer readable medium [101] comprising functional modules including (i) a design module for enabling designing of nucleic acid constructs; (ii) interactive user interface module for visualizing biological information relating to design operations; (iii) transaction module for purchasing a user-designed or pre-stocked nucleic acid constructs (iv) a detecting module for detecting designed nucleic acid sequences comprises harmful sequences; the system is operating in a method of: (a) visualizing biological information; (b) designing nucleic acid sequences; (c) detecting and notifying when harmful sequences are designed; (d) providing means for transactions regarding ordering and purchasing said synthesized nucleic acids.
    Type: Application
    Filed: August 30, 2012
    Publication date: April 30, 2015
    Applicant: GENOME COMPILER CORPORATION
    Inventors: Omri Amirav-Drory, Nir Ben Moshe
  • Publication number: 20150112659
    Abstract: In a first aspect, the present invention relates to a method for patient-specific virtual percutaneous implantation, comprising estimating a patient-specific anatomical model of a patient-specific aorta based on cardiovascular 2D or 3D medical image data and virtually deploying an implant model representing an implant into said patient-specific anatomical model. In a second aspect, the present invention provides a method for patient-specific virtual percutaneous implantation. In a third aspect, the present invention provides an implant for virtual percutaneous implantation. In a fourth aspect, the present invention provides a system for virtual percutaneous implantation.
    Type: Application
    Filed: April 23, 2013
    Publication date: April 23, 2015
    Inventor: Peter Mortier
  • Publication number: 20150112658
    Abstract: The invention generally provides systems and methods for analysis of RNA-Seq reads in which an annotated reference is represented as a directed acyclic graph (DAG) or similar data structure. Features such as exons and introns from the reference provide nodes in the DAG and those features are linked as pairs in their canonical genomic order by edges. The DAG can scale to any size and can in fact be populated in the first instance by import from an extrinsic annotated reference.
    Type: Application
    Filed: January 17, 2014
    Publication date: April 23, 2015
    Applicant: SEVEN BRIDGES GENOMICS INC.
    Inventors: Deniz Kural, Nathan Meyvis
  • Publication number: 20150105315
    Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.
    Type: Application
    Filed: October 21, 2014
    Publication date: April 16, 2015
    Applicants: EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL), UNIVERSITY JOSEPH FOURIER FILIALE, Centre National de la Recherche Scientifique - Direction de la Politique Industrielle
    Inventors: Denis Bouvier, Thibaut Crepin, Rob Ruigrok, Alexander Dias, Stephen Cusack
  • Patent number: 9009015
    Abstract: In a free energy difference estimation method, the partial free energy difference indicates a bound state between a target compound and a first candidate compound bindable to the target compound, and is stored in a storage part for each value of a binding constant. A change region, in which a partial free energy difference is equal to or greater than a predetermined change value, is specified in a region of the binding constant. The partial free energy difference of a second candidate compound in the change region is interpolated based on the partial free energy difference acquired in each of a previous region and a following region by using an approximation function.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: April 14, 2015
    Assignee: Fujitsu Limited
    Inventor: Yoshiaki Tanida
  • Patent number: 9009016
    Abstract: A method for measuring the cerebral perfusion of a living organism (1) by means of magnetic resonance (=“MR”) imaging proposes acquisition of further MR signals in a slice (5) that is pervaded by an artery that supplies the blood to the brain in order to determine the temporal progression of the concentration of the contrast medium during the bolus passage in the artery. During acquisition of the further MR signals, a magnetic field gradient is applied in such a way that projection images of the slice are generated. In each time interval between the excitations of the further MR signals, at least one radio-frequency (=“RF”) pulse is irradiated that causes saturation of the nuclear spin magnetization in the slice. This enables simultaneous measurement of the contrast medium flow in the vessels supplying the brain and the brain tissue within the same sequence with an adapted dynamic range.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: April 14, 2015
    Assignee: Universitaetsklinikum Freiburg
    Inventors: Valerij Kiselev, Elias Kellner
  • Publication number: 20150100294
    Abstract: A method includes receiving characteristics of a patient to be administered a sedative for a medical procedure. The method also includes selecting one of multiple models based on at least one of the characteristics and a sedation technique to be used. The method further includes calculating an index to the selected model using one or more of the characteristics. In addition, the method includes identifying a specified dosage of the sedative using the selected model and calculated index. The characteristics of the patient could include a height, weight, age, and race of the patient. Selecting one of the models could include selecting one of the models based on the patient's race and the sedation technique. The models could include different models associated with different sedation techniques. Calculating the index could include multiplying the patient's height by the patient's weight and dividing a resulting product by the patient's age.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 9, 2015
    Inventors: Louis J. Wilson, Dale B. McDonald, James N. Johnston
  • Patent number: 9002654
    Abstract: The present invention relates to methods of measuring biomarkers to determine the probability of a periodontal and/or peri-implant disease. More specifically, the invention provides a panel of biomarkers that, when used in combination, can allow determination of the probability of a periodontal and/or peri-implant disease state with extremely high accuracy.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: April 7, 2015
    Assignees: The Regents of the University of Michigan, Sandia National Laboratories
    Inventors: Thomas Braun, William V. Giannobile, Amy E. Herr, Anup K. Singh, Charlie Shelburne
  • Patent number: 8998808
    Abstract: A generic model structure captures basic characteristics in BIS-based patients' responses to anesthesia and surgical stimulation, the model being used in combination with the insight of an anesthesiologist. The model structure represents the patient response with a time delay, a time constant for response speed, and a nonlinear function for drug sensitivity. Clinical data confirms the model structure and is used to establish parameters and function forms for individual patients. A feedback and predictive control strategy for anesthesia drug infusion is then introduced on the basis of the patient model. Feedback control alone cannot avoid large fluctuations in BIS values when significant surgical stimulation is imposed, as a result of time delays in a patient's response to drug infusion. Predictive control attenuates fluctuations of BIS levels from surgical stimulation.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: April 7, 2015
    Assignee: Wayne State University
    Inventors: Le Yi Wang, Hong Wang, Gang George Yin
  • Patent number: 9002655
    Abstract: A medical apparatus for extracorporeal blood treatment and a method for determining blood parameter value have been provided. The medical apparatus has a control unit (9) configured for taking from a storage memory (10) a plurality of blood parameter value measures each made through the sensors (8) provided on the bloodline set of each of a machines plurality at different patient treatment sessions; all the blood parameter values relate to the same patient; receiving at least a corresponding laboratory measured value of the same blood parameter relating to the same patient and a laboratory measurement time; determining a correction factor function of a difference between a measured value made though the sensor and a laboratory measured value; obtaining an actual value of said blood parameter by varying at least the last measure made through the sensor by means of the correcting factor.
    Type: Grant
    Filed: May 3, 2010
    Date of Patent: April 7, 2015
    Assignee: Gambro Lundia AB
    Inventor: Bernard Bene
  • Publication number: 20150094226
    Abstract: The present invention provides detailed three-dimensional structural information for the complex formed by the Nef protein and the sdAb19 antibody fragment. In addition, the present invention also provides residues which mediate the interaction between the Nef protein and the sdAb19 antibody fragment. The present invention also provides methods for identifying compounds modulating the interaction of the Nef protein and the sdAb19 antibody.
    Type: Application
    Filed: October 1, 2014
    Publication date: April 2, 2015
    Inventors: Serge BENICHOU, Matthias GEYER, Sebastian LULF
  • Publication number: 20150095007
    Abstract: A method and system is disclosed for estimating the difference between binding free energies of molecules.
    Type: Application
    Filed: March 20, 2013
    Publication date: April 2, 2015
    Inventors: Alexander D. Mackerell, Prabhu E. Raman
  • Patent number: 8990059
    Abstract: The invention relates to a method and apparatus for obtaining information from an amplification curve of a target nucleic acid sequence or sequences by defining at least one model function that describes the amplification curve and that contains at least one parameter that is related to a physical quantity that influences the signals recorded, fitting said model function to the amplification curve, and obtaining information with respect to said physical quantity by identifying the value of said parameter that results in the best fit of the model function.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: March 24, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Josephus Arnoldus Henricus Maria Kahlman, Tamara Mathea Elisabeth Nijsen, Bin Yin
  • Publication number: 20150079544
    Abstract: Embodiments are provided for digital dental modeling. One method embodiment includes receiving a three-dimensional data set including a first jaw and a second jaw of a three-dimensional digital dental model and receiving a two-dimensional data set corresponding to at least a portion of the first jaw and the second jaw. The method includes mapping two-dimensional data of the two-dimensional data set to the three-dimensional digital dental model by transforming a coordinate system of the two-dimensional data to a coordinate system of the three-dimensional data set. The method includes positioning the first jaw with respect to the second jaw based on the two-dimensional data mapped to the three-dimensional data set. The method includes using at least a portion of the two-dimensional data mapped to the three-dimensional data set as a target of movement of the first jaw with respect to the second jaw in the three-dimensional digital dental model.
    Type: Application
    Filed: November 25, 2014
    Publication date: March 19, 2015
    Inventors: Anatoliy Boltunov, Yury Brailov, Fedor Chelnokov, Roman A. Roschin, David Mason
  • Publication number: 20150081258
    Abstract: A method of tracking a plurality of tagged molecules in a cell in two or three dimensions may include receiving a plurality of unambiguous track segments, where each of the plurality of unambiguous track segments may include a plurality of time-valued observations of individual tagged molecules. The method may also include separating the plurality of unambiguous track segments into a plurality of time windows. The method may additionally include, for each of the plurality of unambiguous track segments, deriving one or more data sets representing features of the unambiguous track segment. The method may further include associating a first unambiguous track segment from a first time window with a second unambiguous track segment from a second time window using the one or more data sets.
    Type: Application
    Filed: September 18, 2013
    Publication date: March 19, 2015
    Applicant: NUMERICA CORP.
    Inventors: CHRISTOPHER P. CALDERON, RANDY C. PAFFENROTH
  • Publication number: 20150073767
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Application
    Filed: November 13, 2014
    Publication date: March 12, 2015
    Inventors: Gregory R. HART, John H. STEVENS
  • Publication number: 20150073765
    Abstract: A method and system for prediction of respiratory motion from 3D thoracic images is disclosed. A patient-specific anatomical model of the respiratory system is generated from 3D thoracic images of a patient. The patient-specific anatomical model of the respiratory system is deformed using a biomechanical model. The biomechanical model is personalized for the patient by estimating a patient-specific thoracic pressure force field to drive the biomechanical model. Respiratory motion of the patient is predicted using the personalized biomechanical model driven by the patient-specific thoracic pressure force field.
    Type: Application
    Filed: August 25, 2014
    Publication date: March 12, 2015
    Inventors: Thomas Boettger, Francois Carnis, Dorin Comaniciu, Jerome Declerck, Bernhard Fuerst, Ali Kamen, Tommaso Mansi, Jingdan Zhang
  • Publication number: 20150073766
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Application
    Filed: November 13, 2014
    Publication date: March 12, 2015
    Inventors: Gregory R. HART, John H. STEVENS
  • Patent number: 8977504
    Abstract: Apparatus for monitoring a substance in human or animal in real time, the apparatus comprising a sensor providing a time series of measurements of substance level, said measurements being indicative of an inferred level of said substance in a part of said human or animal and a processor which applies an interacting multiple model strategy to a system model to provide a combined estimate of the inferred substance level from the substance level measurements. The substance may be glucose. The apparatus may also be adapted to control said substance using said interacting multiple model strategy to a system model to provide a combined estimate of a dose to be applied.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: March 10, 2015
    Assignee: Cambridge Enterprise Limited
    Inventor: Roman Hovorka
  • Patent number: 8977506
    Abstract: A computer having a memory stores instructions for receiving data. The data comprises one or more characteristics for each cellular constituent in a plurality of cellular constituents that have been measured in a test organism of a species or a test biological specimen from an organism of the species. The memory further stores instructions for computing a model in a plurality of models, wherein the model is characterized by a model score that represents the likelihood of a biological feature in the test organism or the test biological specimen. Computation of the model comprises determining the model score using one or more characteristics for one or more cellular constituents in the plurality of cellular constituents. The memory also stores instructions for repeating the instructions for computing one or more times, thereby computing the plurality of models. The memory also stores instructions for communicating computed model scores.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: March 10, 2015
    Assignee: Response Genetics, Inc.
    Inventor: Glenda G. Anderson
  • Patent number: 8977530
    Abstract: Provided is a method for improving useful substance-producing organisms using metabolic flux analysis, and more particularly a method for improving a host organism producing a useful substance, the method including: calculating a maximum flux value corresponding to the theoretical maximum yield of the useful substance in the metabolic network model of the host organism for producing useful substance, and calculating the optimum value of metabolic flux associated with useful substance production in the metabolic network when the value of cell growth-associated metabolic flux is the maximum under the condition where fermentation data are applied or not applied; selecting metabolic fluxes whose absolute values increase from the range between the maximum value and the optimum value; screening genes associated with the selected metabolic fluxes; and introducing and/or amplifying the selected genes in the host organism. Production of the useful substance can be effectively improved by using the method.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: March 10, 2015
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Sang Yup Lee, Han Min Woo, Hyung Seok Choi