Biological Or Biochemical Patents (Class 703/11)
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Patent number: 9443343Abstract: Provided is a method and apparatus for realistically reproducing an eyeball that may verify and analyze a material property and a deformation property with respect to each of constituent portions of an eyeball and may render each of the constituent portions based on the analyzed priorities, thereby more realistically reproducing the eyeball.Type: GrantFiled: November 23, 2011Date of Patent: September 13, 2016Assignees: Samsung Electronics Co., Ltd., University of Southern CaliforniaInventors: Tae Hyun Rhee, Seon Min Rhee, Hyun Jung Shim, Do Kyoon Kim, Abhijeet Ghosh, Jay Busch, Jen-Yuan Chiang, Paul Debevec
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Patent number: 9424337Abstract: A method of determining a number of clusters for a dataset is provided. Centroid locations for a defined number of clusters are determined using a clustering algorithm. Boundaries for each of the defined clusters are defined. A reference distribution that includes a plurality of data points is created. The plurality of data points are within the defined boundary of at least one cluster of the defined clusters. Second centroid locations for the defined number of clusters are determined using the clustering algorithm and the reference distribution. A gap statistic for the defined number of clusters based on a comparison between a first residual sum of squares and a second residual sum of squares is computed. The processing is repeated for a next number of clusters to create. An estimated best number of clusters for the received data is determined by comparing the gap statistic computed for each iteration of the number of clusters.Type: GrantFiled: March 4, 2014Date of Patent: August 23, 2016Assignee: SAS Institute Inc.Inventors: Patrick Hall, Ilknur Kaynar Kabul, Warren Sarle, Jorge Silva
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Patent number: 9424761Abstract: Simulation systems and methods may enable medical training. A manufacturing unit may receive data from a configuration unit indicating identification and manufacturing parameters for an anatomy model. A data processing unit may receive data from the configuration unit identifying the anatomy model, and data from a calibration unit indicating a position and/or orientation of a position and orientation sensor relative to the anatomy model. The data processing unit may also receive data from the position and orientation sensor indicating a position and/or orientation of the anatomy model. The data processing unit may generate a virtual image using the data from the position and orientation sensor, the data from the calibration unit, and the data from the configuration unit. The data processing unit may render the virtual image to a display.Type: GrantFiled: July 16, 2015Date of Patent: August 23, 2016Assignee: VIRTAMED AGInventors: Stefan Tuchschmid, Carolyn O'Brien, Daniel Bachofen, Matthias Harders, Jonas Spillmann
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Patent number: 9390232Abstract: Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.Type: GrantFiled: June 27, 2014Date of Patent: July 12, 2016Assignee: HeartFlow, Inc.Inventors: Charles A. Taylor, Hyun Jin Kim, Sethuraman Sankaran, Michiel Schaap, David Eberle, Gilwoo Choi, Leo Grady
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Patent number: 9373486Abstract: Systems and methods are provided for species detection using mass spectrometry. In various embodiments, a multiple reaction monitoring (MRM) experiment is performed on a sample targeting one or more peptide transitions that are unique to one or more species using a tandem mass spectrometer. One or more measured product ion spectra are received from the tandem mass spectrometer using the processor. The one or more measured product ion spectra are compared to product ions of the one or more peptide transitions that are unique to one or more species using the processor. One or more species of the sample are detected by reporting product ions of the one or more peptide transitions that are unique to one or more species that match the one or more measured product ion spectra using the processor.Type: GrantFiled: May 19, 2014Date of Patent: June 21, 2016Assignee: DH Technologies Development Pte. Ltd.Inventor: Stephen Lock
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Patent number: 9349178Abstract: In hemodynamic determination in medical imaging, the classifier is trained from synthetic data rather than relying on training data from other patients. A computer model (in silico) may be perturbed in many different ways to generate many different examples. The flow is calculated for each resulting example. A bench model (in vitro) may similarly be altered in many different ways. The flow is measured for each resulting example. The machine-learnt classifier uses features from medical scan data for a particular patient to estimate the blood flow based on mapping of features to flow learned from the synthetic data. Perturbations or alterations may account for therapy so that the machine-trained classifier may estimate the results of therapeutically altering a patient-specific input feature. Uncertainty may be handled by training the classifier to predict a distribution of possibilities given uncertain input distribution.Type: GrantFiled: July 21, 2015Date of Patent: May 24, 2016Assignee: Siemens AktiengesellschaftInventors: Lucian Mihai Itu, Tiziano Passerini, Saikiran Rapaka, Puneet Sharma, Chris Schwemmer, Max Schoebinger, Thomas Redel, Dorin Comaniciu
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Patent number: 9299145Abstract: Systems and articles of manufacture for image segmentation are provided herein, and include creating an anatomical model from training data comprising one or more imaging modalities, generating one or more simulated images in a target modality based on the anatomical model and one or more principles of physics pertaining to image contrast generation, and comparing the one or more simulated images to an unlabeled input image of a given imaging modality to determine a simulated image of the one or more simulated images to represent the unlabeled input image.Type: GrantFiled: August 28, 2013Date of Patent: March 29, 2016Assignee: International Business Machines CorporationInventors: Noel C. Codella, John R. Smith
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Patent number: 9240062Abstract: A node arranging apparatus includes: a node arranging unit that arranges, in a virtual three-dimensional space, nodes indicated by inter-node information stored in an inter-node information storage unit; a node moving unit that moves each node using a movement amount and a movement direction of that node determined by arrangement relationship of that node with a first plane, arrangement relationship with another node arranged in the virtual three-dimensional space, and arrangement relationship with at least one other node associated therewith by the inter-node information and arranged in the virtual three-dimensional space; a display information generating unit that generates display information of a node connection image where nodes are projected and connected; and an output unit that outputs the display information. The node moving unit repeatedly performs at least once the node moving process until a predesignated condition is satisfied.Type: GrantFiled: October 10, 2014Date of Patent: January 19, 2016Assignee: SOFTWARE CRADLE CO., LTD.Inventor: Hiroshi Morikawa
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Patent number: 9220572Abstract: A method of implanting a hip joint prosthesis into a patient can include obtaining image data of hip joint anatomy of the patient. Physical activities that the patient desires to participate in subsequent to implanting the hip prosthesis can be determined. A size and an initial placement of the hip joint prosthesis based on the image data can be determined. A desired range of motion of the hip joint prosthesis based on the determined physical activities can be determined. A plan can be created comprising a desired implanted location of the hip joint prosthesis and based on the desired range of motion. The plan can be incorporated onto a guide. The plan can be executed with the guide thereby implanting the hip joint prosthesis into the patient at the desired implanted position.Type: GrantFiled: November 1, 2013Date of Patent: December 29, 2015Assignee: Biomet Manufacturing, LLCInventors: Jason Meridew, William Jason Slone, Mark Scrafton, John White, Seth Nash
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Patent number: 9215988Abstract: A cardiac signal generator includes a portable housing, a memory, a processing device, a digital to analog converter, and at least one analog output. The memory stores programming instructions including instructions defining a plurality of mathematical relationships. The processing device is configured to execute the programming instructions to generate a sequence of output values using the plurality of mathematic relationships as a function of time, wherein the sequence of output values defines a sampled waveform output simulating an ECG signal and having linear portions and at least one curved portion. The processing device furthermore provides the sequence of output values at an output. The digital to analog converter is operably coupled to receive the sequence of output values from the output, and generates an electrical signal having a waveform corresponding to the sampled waveform output. The analog output is operably coupled to the digital to analog converter.Type: GrantFiled: March 27, 2013Date of Patent: December 22, 2015Assignee: Medxcel, LLCInventors: Robert Cadick, Dax Hafer
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Patent number: 9218745Abstract: A system for neuromuscular training via a communication network, including a computer processor connectable to the communication network, the processor capable of performing operations including: retrieving data representative of a training scenario from a database in response to a user selection on an input device, generating test elements, parameters and controls based on the retrieved data, monitoring use of the input device by the user, performing calculations of a simulated environment in response to the use of the input device by the user and the test elements, parameters and controls, generating real time images replicating the simulated environment of management of the test elements by the user and recording results of the simulation in the database.Type: GrantFiled: March 14, 2013Date of Patent: December 22, 2015Assignee: 123 CERTIFICATION INC.Inventor: Claude Choquet
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Patent number: 9202010Abstract: Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.Type: GrantFiled: July 3, 2014Date of Patent: December 1, 2015Assignee: HeartFlow, Inc.Inventors: Charles A. Taylor, Hyun Jin Kim, Sethuraman Sankaran, Michiel Schaap, David Eberle, Gilwoo Choi, Leo Grady
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Patent number: 9189747Abstract: Methods, systems, and apparatus, including computer programs encoded on one or more computer storage devices, for training a predictive model. In one aspect, a method includes receiving over a network predictive modeling training data from a client computing system. The training data and multiple training functions obtained from a repository of training functions are used to train multiple predictive models. A score is generated for each of the trained predictive models, where each score represents an estimation of the effectiveness of the respective trained predictive model. A first trained predictive model is selected from among the trained predictive models based on the generated scores. Access to the first trained predictive model is provided over the network.Type: GrantFiled: July 20, 2012Date of Patent: November 17, 2015Assignee: Google Inc.Inventors: Gideon S. Mann, Jordan M. Breckenridge, Wei-Hao Lin
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Patent number: 9173574Abstract: A probabilistic data signal processor used to determine health of a system is described. Initial probability distribution functions are input to a dynamic state-space model, which iteratively operates on probability distribution functions, such as state and model probability distribution functions, to generate a prior probability distribution function, which is input to a probabilistic updater. The probabilistic updater integrates sensor data with the prior to generate a posterior probability distribution function passed to a probabilistic sampler, which estimates one or more parameters using the posterior, which is output or re-sampled and used as an input to the dynamic state-space model in the iterative algorithm. In various embodiments, the probabilistic data signal processor is used to filter output from any mechanical device using appropriate physical models, which optionally include chemical, electrical, optical, mechanical, or fluid based models.Type: GrantFiled: April 28, 2011Date of Patent: November 3, 2015Inventors: Rodrigo E. Teixeira, Alton Reich
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Patent number: 9136939Abstract: A handheld diabetes manager is presented with an improved graphical user interface for a bolus calculator. The bolus calculator is configured to receive blood glucose measurements from a blood glucose measurement module and operates, in response to an input, to compute an insulin recommendation for a patient based in part on the blood glucose measurements. The graphical user interface for the bolus calculator includes a health adjustment screen that enables a user to input a value for health events associated with the insulin recommendation, where the input value represents a cumulative effect of the health events on insulin of the patient and the health adjustment screen presents a different icon for each of the health events associated with the insulin recommendation.Type: GrantFiled: August 27, 2012Date of Patent: September 15, 2015Assignee: Roche Diabetes Care, Inc.Inventors: Paul J. Galley, Mark G. Mears, Phillip E. Pash, Vincent R. Rizzo, Bettina Steiner, Kristin M. Westerfield, Richard W. Wilson
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Patent number: 9135381Abstract: A computer-implemented method for simulating blood flow through a heart valve may first involve receiving patient-specific data, including imaging data related to the heart valve, an inflow tract of the heart valve and an outflow tract of the heart valve, and at least one clinically measured flow parameter. Next, the method may involve generating a digital model of the heart valve and the inflow and outflow tracts, based at least partially on the imaging data, discretizing the model, applying boundary conditions to a portion of the digital model that contains the heart valve and the inflow and outflow tracts, and initializing and solving mathematical equations of blood flow through the model to generate computerized flow parameters. Finally, the method may involve comparing the computerized flow parameters with the at least one clinically measured flow parameter.Type: GrantFiled: April 29, 2014Date of Patent: September 15, 2015Assignee: STENOMICS, INC.Inventor: Michael A. Singer
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Patent number: 9121847Abstract: Provided are methods and devices for formation and study of three-dimensional biological systems, including prokaryotic and eukaryotic cell migration, proliferation, and differentiation.Type: GrantFiled: April 3, 2009Date of Patent: September 1, 2015Assignee: Massachussetts Institute of TechnologyInventors: Roger D. Kamm, Seok Chung, Vernella V. Vickerman-Kelley
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Patent number: 9047025Abstract: A system for print service provider (PSP) operations management includes a provenance analytics engine. The provenance analytics engine accesses fresh meta-data associated with fresh events in a PSP operation performed using a printing system operated by a PSP. The provenance analytics engine further accesses stored meta-data associated with past events related to past PSP operations. Still further, the provenance analytics engine accesses a component behavioral model (CBM) to produce results associated with events in a PSP operation. The provenance analytics engine analyzes the event-related meta-data.Type: GrantFiled: April 20, 2012Date of Patent: June 2, 2015Assignee: Hewlett-Packard Development Company, L.P.Inventors: Jun Zeng, Eric Hoarau, I-Jong Lin
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Patent number: 9043190Abstract: Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising acquiring an anatomical model of at least part of the patient's vascular system; performing, using a processor, one or more of geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical model; and identifying, using the processor, a personalized cardiovascular device for the patient, based on results of one or more of the geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of anatomical model.Type: GrantFiled: April 16, 2014Date of Patent: May 26, 2015Assignee: HeartFlow, Inc.Inventors: Leo Grady, Charles A. Taylor, Gilwoo Choi, Campbell Rogers
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Patent number: 9039612Abstract: A coiling parameterization tool includes a processor and a display for displaying values of lumen volume, packing and coiling parameters for filling a lumen in relation to a desired packing. The processor is configured to detect a change in one of the displayed values and, in response to the change, to automatically evaluate, change and display remaining values displayed on the display.Type: GrantFiled: October 14, 2010Date of Patent: May 26, 2015Assignee: Koninklijke Philips N.V.Inventors: Pieter Maria Mielekamp, Drazenko Babic
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Patent number: 9043157Abstract: A device for the collection and processing of information relating to the exposure of one or more persons to one or more products of chemical or biological origin has: at least one coded sensor for automatic or semi-automatic identification of a person likely to be exposed to at least one product, at least one coded sensor for the collection of information relating to the handling of at least one product by the person likely to be exposed to the product, at least one sensor for validating the information collected by the identification and collection sensors, at least one module for reading at least one coded sensor, and a module for processing information collected by the sensors.Type: GrantFiled: February 3, 2010Date of Patent: May 26, 2015Assignee: BIOGEMMAInventors: Didier Hatsch, Pascual Perez
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Patent number: 9043191Abstract: Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising: generating a patient specific model of at least a portion of a patient's vasculature from image data of the patient's vasculature and one or more measured or estimated physiological or phenotypic parameters of the patient; determining pathology characteristics from cardiovascular geometry of the patient specific model; defining an objective function for a device based on design considerations and one or more estimates of hemodynamic and mechanical characteristics; optimizing the objective function, by simulating at least one change in devices and evaluating the objective function using fluid dynamic or structural mechanic analysis; and using the optimized objective function to either (i) select a device from a set of available devices or (ii) manufacture a desired device.Type: GrantFiled: April 16, 2014Date of Patent: May 26, 2015Assignee: HeartFlow, Inc.Inventors: Leo Grady, Charles A. Taylor, Gilwoo Choi, Campbell Rogers
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Publication number: 20150142408Abstract: Some embodiments include a computer-assisted method of biomedical treatment design. For example, a computer system can select a compound model associated with a candidate compound that is structured to bind to a biological target to modulate the biological target into achieving a therapeutic effect. The computer system can then identify a structural feature in the compound model as a hinge region that connects domains in the candidate compound. The computer system then determines a mutation process to introduce a mutation at the hinge region such that the mutation activates the candidate compound. The computer system then generates an updated compound model based on the mutation added to the candidate compound to present in a treatment design interface.Type: ApplicationFiled: November 17, 2014Publication date: May 21, 2015Inventor: Akiko Futamura
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Patent number: 9037445Abstract: Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium; calculating metabolic flux reorganization in various environments and at various growth rates; and calculating the maximum metabolic rate and optimal metabolite concentrations and enzyme activities by applying a computational optimization method to a kinetic model of a metabolic pathway. The optimization methods use intracellular molecular crowding parameters and/or well as kinetic rates to assist in modeling metabolic activity.Type: GrantFiled: July 10, 2008Date of Patent: May 19, 2015Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Zoltan N. Oltvai, Alexei Vazquez
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Publication number: 20150134316Abstract: Treatment validation techniques include generating a modified treatment target from an original treatment target using a modification process, and comparing induced aberrations provided by the original and modified treatment targets, so as to verify the modified treatment target or the modification process. In some cases, a modification process may include a deconvolution process, a low pass filter process, a scaling process, or an adjustment process. The induced aberrations may include high order aberrations, such as spherical aberration.Type: ApplicationFiled: November 7, 2014Publication date: May 14, 2015Inventors: Guang-ming Dai, Anatoly Fabrikant, Dimitri Chernyak, Jayesh Shah
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Publication number: 20150131866Abstract: The invention is a method using a computer to construct a grid representative of the distribution of a physical property of an underground formation having application to petroleum reservoir development. A set of initial grid cells MI containing at least one conditioning point PC is defined. Each cell MI is then visited and assigned a value representative of the property using a filling method. At least one unvisited cell (MNV1, MNV2) adjacent to at least one already visited cell MV is then identified, and the number N of adjacent cells MV is determined for each cell (MNV1, MNV2). Each cell (MNV1, MNV2) is then visited and filled according to the decreasing values of N. The stages of identification and filling of cells (MNV1, MNV2) are repeated until each cell of the grid has been visited.Type: ApplicationFiled: November 12, 2014Publication date: May 14, 2015Inventor: Mickaele LE RAVALEC
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Publication number: 20150134315Abstract: Disclosed are methods for building a sequence activity model with reference to structural data, which model can be used to guide directed evolution of proteins having beneficial properties. Some embodiments use genetic algorithms and structural data to filter out uninformative data. Some embodiments use a support vector machine to train the sequence activity model. The filtering and training methods can generate a sequence activity model having higher predictive power than conventional modeling methods. Systems and computer program products implementing the methods are also provided.Type: ApplicationFiled: September 26, 2014Publication date: May 14, 2015Inventors: Russell Javiniar Sarmiento, Donald Scott Baskerville, Xiyun Zhang
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Publication number: 20150127317Abstract: The present invention provides an integrated model of metabolic and macromolecular expression (ME-Model), and a method for reconstructing an ME-Model from biological data. Specifically, the present invention provides a ME-Model which uses a biochemical knowledgebase of an organism to accurately determine the metabolic and macromolecular phenotype of the organism under different conditions. Further, the present invention provides a method to determine the most efficient conditions for producing a product from an organism.Type: ApplicationFiled: May 9, 2013Publication date: May 7, 2015Inventors: Daniel R. Hyduke, Joshua A. Lerman, Bernhard O. Palsson, Edward O'Brien
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Publication number: 20150127316Abstract: A system and method for converting static/still medical images of a particular patient into dynamic and interactive images interacting with medical tools including medical devices by coupling a model of tissue dynamics and tool characteristics to the patient specific imagery for simulating a medical procedure in an accurate and dynamic manner by coupling a model of tissue dynamics to patient specific imagery for simulating cerebral aneurysm clipping surgery.Type: ApplicationFiled: March 30, 2012Publication date: May 7, 2015Inventor: Mordechai Avisar
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Publication number: 20150120265Abstract: The present invention disclose a computerized system for designing nucleic acid sequences for gene expression comprising; (a) a server [103] for hosting a database [106] (b) a network connection [102] and (c) a computer readable medium [101] comprising functional modules including (i) a design module for enabling designing of nucleic acid constructs; (ii) interactive user interface module for visualizing biological information relating to design operations; (iii) transaction module for purchasing a user-designed or pre-stocked nucleic acid constructs (iv) a detecting module for detecting designed nucleic acid sequences comprises harmful sequences; the system is operating in a method of: (a) visualizing biological information; (b) designing nucleic acid sequences; (c) detecting and notifying when harmful sequences are designed; (d) providing means for transactions regarding ordering and purchasing said synthesized nucleic acids.Type: ApplicationFiled: August 30, 2012Publication date: April 30, 2015Applicant: GENOME COMPILER CORPORATIONInventors: Omri Amirav-Drory, Nir Ben Moshe
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Publication number: 20150112659Abstract: In a first aspect, the present invention relates to a method for patient-specific virtual percutaneous implantation, comprising estimating a patient-specific anatomical model of a patient-specific aorta based on cardiovascular 2D or 3D medical image data and virtually deploying an implant model representing an implant into said patient-specific anatomical model. In a second aspect, the present invention provides a method for patient-specific virtual percutaneous implantation. In a third aspect, the present invention provides an implant for virtual percutaneous implantation. In a fourth aspect, the present invention provides a system for virtual percutaneous implantation.Type: ApplicationFiled: April 23, 2013Publication date: April 23, 2015Inventor: Peter Mortier
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Publication number: 20150112658Abstract: The invention generally provides systems and methods for analysis of RNA-Seq reads in which an annotated reference is represented as a directed acyclic graph (DAG) or similar data structure. Features such as exons and introns from the reference provide nodes in the DAG and those features are linked as pairs in their canonical genomic order by edges. The DAG can scale to any size and can in fact be populated in the first instance by import from an extrinsic annotated reference.Type: ApplicationFiled: January 17, 2014Publication date: April 23, 2015Applicant: SEVEN BRIDGES GENOMICS INC.Inventors: Deniz Kural, Nathan Meyvis
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Publication number: 20150105315Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.Type: ApplicationFiled: October 21, 2014Publication date: April 16, 2015Applicants: EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL), UNIVERSITY JOSEPH FOURIER FILIALE, Centre National de la Recherche Scientifique - Direction de la Politique IndustrielleInventors: Denis Bouvier, Thibaut Crepin, Rob Ruigrok, Alexander Dias, Stephen Cusack
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Patent number: 9009015Abstract: In a free energy difference estimation method, the partial free energy difference indicates a bound state between a target compound and a first candidate compound bindable to the target compound, and is stored in a storage part for each value of a binding constant. A change region, in which a partial free energy difference is equal to or greater than a predetermined change value, is specified in a region of the binding constant. The partial free energy difference of a second candidate compound in the change region is interpolated based on the partial free energy difference acquired in each of a previous region and a following region by using an approximation function.Type: GrantFiled: February 6, 2012Date of Patent: April 14, 2015Assignee: Fujitsu LimitedInventor: Yoshiaki Tanida
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Patent number: 9009016Abstract: A method for measuring the cerebral perfusion of a living organism (1) by means of magnetic resonance (=“MR”) imaging proposes acquisition of further MR signals in a slice (5) that is pervaded by an artery that supplies the blood to the brain in order to determine the temporal progression of the concentration of the contrast medium during the bolus passage in the artery. During acquisition of the further MR signals, a magnetic field gradient is applied in such a way that projection images of the slice are generated. In each time interval between the excitations of the further MR signals, at least one radio-frequency (=“RF”) pulse is irradiated that causes saturation of the nuclear spin magnetization in the slice. This enables simultaneous measurement of the contrast medium flow in the vessels supplying the brain and the brain tissue within the same sequence with an adapted dynamic range.Type: GrantFiled: October 15, 2012Date of Patent: April 14, 2015Assignee: Universitaetsklinikum FreiburgInventors: Valerij Kiselev, Elias Kellner
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Publication number: 20150100294Abstract: A method includes receiving characteristics of a patient to be administered a sedative for a medical procedure. The method also includes selecting one of multiple models based on at least one of the characteristics and a sedation technique to be used. The method further includes calculating an index to the selected model using one or more of the characteristics. In addition, the method includes identifying a specified dosage of the sedative using the selected model and calculated index. The characteristics of the patient could include a height, weight, age, and race of the patient. Selecting one of the models could include selecting one of the models based on the patient's race and the sedation technique. The models could include different models associated with different sedation techniques. Calculating the index could include multiplying the patient's height by the patient's weight and dividing a resulting product by the patient's age.Type: ApplicationFiled: October 9, 2013Publication date: April 9, 2015Inventors: Louis J. Wilson, Dale B. McDonald, James N. Johnston
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Patent number: 9002654Abstract: The present invention relates to methods of measuring biomarkers to determine the probability of a periodontal and/or peri-implant disease. More specifically, the invention provides a panel of biomarkers that, when used in combination, can allow determination of the probability of a periodontal and/or peri-implant disease state with extremely high accuracy.Type: GrantFiled: July 30, 2008Date of Patent: April 7, 2015Assignees: The Regents of the University of Michigan, Sandia National LaboratoriesInventors: Thomas Braun, William V. Giannobile, Amy E. Herr, Anup K. Singh, Charlie Shelburne
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Patent number: 8998808Abstract: A generic model structure captures basic characteristics in BIS-based patients' responses to anesthesia and surgical stimulation, the model being used in combination with the insight of an anesthesiologist. The model structure represents the patient response with a time delay, a time constant for response speed, and a nonlinear function for drug sensitivity. Clinical data confirms the model structure and is used to establish parameters and function forms for individual patients. A feedback and predictive control strategy for anesthesia drug infusion is then introduced on the basis of the patient model. Feedback control alone cannot avoid large fluctuations in BIS values when significant surgical stimulation is imposed, as a result of time delays in a patient's response to drug infusion. Predictive control attenuates fluctuations of BIS levels from surgical stimulation.Type: GrantFiled: June 21, 2004Date of Patent: April 7, 2015Assignee: Wayne State UniversityInventors: Le Yi Wang, Hong Wang, Gang George Yin
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Patent number: 9002655Abstract: A medical apparatus for extracorporeal blood treatment and a method for determining blood parameter value have been provided. The medical apparatus has a control unit (9) configured for taking from a storage memory (10) a plurality of blood parameter value measures each made through the sensors (8) provided on the bloodline set of each of a machines plurality at different patient treatment sessions; all the blood parameter values relate to the same patient; receiving at least a corresponding laboratory measured value of the same blood parameter relating to the same patient and a laboratory measurement time; determining a correction factor function of a difference between a measured value made though the sensor and a laboratory measured value; obtaining an actual value of said blood parameter by varying at least the last measure made through the sensor by means of the correcting factor.Type: GrantFiled: May 3, 2010Date of Patent: April 7, 2015Assignee: Gambro Lundia ABInventor: Bernard Bene
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Publication number: 20150094226Abstract: The present invention provides detailed three-dimensional structural information for the complex formed by the Nef protein and the sdAb19 antibody fragment. In addition, the present invention also provides residues which mediate the interaction between the Nef protein and the sdAb19 antibody fragment. The present invention also provides methods for identifying compounds modulating the interaction of the Nef protein and the sdAb19 antibody.Type: ApplicationFiled: October 1, 2014Publication date: April 2, 2015Inventors: Serge BENICHOU, Matthias GEYER, Sebastian LULF
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Publication number: 20150095007Abstract: A method and system is disclosed for estimating the difference between binding free energies of molecules.Type: ApplicationFiled: March 20, 2013Publication date: April 2, 2015Inventors: Alexander D. Mackerell, Prabhu E. Raman
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Patent number: 8990059Abstract: The invention relates to a method and apparatus for obtaining information from an amplification curve of a target nucleic acid sequence or sequences by defining at least one model function that describes the amplification curve and that contains at least one parameter that is related to a physical quantity that influences the signals recorded, fitting said model function to the amplification curve, and obtaining information with respect to said physical quantity by identifying the value of said parameter that results in the best fit of the model function.Type: GrantFiled: October 14, 2010Date of Patent: March 24, 2015Assignee: Koninklijke Philips N.V.Inventors: Josephus Arnoldus Henricus Maria Kahlman, Tamara Mathea Elisabeth Nijsen, Bin Yin
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Publication number: 20150079544Abstract: Embodiments are provided for digital dental modeling. One method embodiment includes receiving a three-dimensional data set including a first jaw and a second jaw of a three-dimensional digital dental model and receiving a two-dimensional data set corresponding to at least a portion of the first jaw and the second jaw. The method includes mapping two-dimensional data of the two-dimensional data set to the three-dimensional digital dental model by transforming a coordinate system of the two-dimensional data to a coordinate system of the three-dimensional data set. The method includes positioning the first jaw with respect to the second jaw based on the two-dimensional data mapped to the three-dimensional data set. The method includes using at least a portion of the two-dimensional data mapped to the three-dimensional data set as a target of movement of the first jaw with respect to the second jaw in the three-dimensional digital dental model.Type: ApplicationFiled: November 25, 2014Publication date: March 19, 2015Inventors: Anatoliy Boltunov, Yury Brailov, Fedor Chelnokov, Roman A. Roschin, David Mason
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Publication number: 20150081258Abstract: A method of tracking a plurality of tagged molecules in a cell in two or three dimensions may include receiving a plurality of unambiguous track segments, where each of the plurality of unambiguous track segments may include a plurality of time-valued observations of individual tagged molecules. The method may also include separating the plurality of unambiguous track segments into a plurality of time windows. The method may additionally include, for each of the plurality of unambiguous track segments, deriving one or more data sets representing features of the unambiguous track segment. The method may further include associating a first unambiguous track segment from a first time window with a second unambiguous track segment from a second time window using the one or more data sets.Type: ApplicationFiled: September 18, 2013Publication date: March 19, 2015Applicant: NUMERICA CORP.Inventors: CHRISTOPHER P. CALDERON, RANDY C. PAFFENROTH
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Publication number: 20150073767Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.Type: ApplicationFiled: November 13, 2014Publication date: March 12, 2015Inventors: Gregory R. HART, John H. STEVENS
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Publication number: 20150073765Abstract: A method and system for prediction of respiratory motion from 3D thoracic images is disclosed. A patient-specific anatomical model of the respiratory system is generated from 3D thoracic images of a patient. The patient-specific anatomical model of the respiratory system is deformed using a biomechanical model. The biomechanical model is personalized for the patient by estimating a patient-specific thoracic pressure force field to drive the biomechanical model. Respiratory motion of the patient is predicted using the personalized biomechanical model driven by the patient-specific thoracic pressure force field.Type: ApplicationFiled: August 25, 2014Publication date: March 12, 2015Inventors: Thomas Boettger, Francois Carnis, Dorin Comaniciu, Jerome Declerck, Bernhard Fuerst, Ali Kamen, Tommaso Mansi, Jingdan Zhang
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Publication number: 20150073766Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.Type: ApplicationFiled: November 13, 2014Publication date: March 12, 2015Inventors: Gregory R. HART, John H. STEVENS
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Patent number: 8977504Abstract: Apparatus for monitoring a substance in human or animal in real time, the apparatus comprising a sensor providing a time series of measurements of substance level, said measurements being indicative of an inferred level of said substance in a part of said human or animal and a processor which applies an interacting multiple model strategy to a system model to provide a combined estimate of the inferred substance level from the substance level measurements. The substance may be glucose. The apparatus may also be adapted to control said substance using said interacting multiple model strategy to a system model to provide a combined estimate of a dose to be applied.Type: GrantFiled: October 10, 2008Date of Patent: March 10, 2015Assignee: Cambridge Enterprise LimitedInventor: Roman Hovorka
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Patent number: 8977506Abstract: A computer having a memory stores instructions for receiving data. The data comprises one or more characteristics for each cellular constituent in a plurality of cellular constituents that have been measured in a test organism of a species or a test biological specimen from an organism of the species. The memory further stores instructions for computing a model in a plurality of models, wherein the model is characterized by a model score that represents the likelihood of a biological feature in the test organism or the test biological specimen. Computation of the model comprises determining the model score using one or more characteristics for one or more cellular constituents in the plurality of cellular constituents. The memory also stores instructions for repeating the instructions for computing one or more times, thereby computing the plurality of models. The memory also stores instructions for communicating computed model scores.Type: GrantFiled: March 13, 2012Date of Patent: March 10, 2015Assignee: Response Genetics, Inc.Inventor: Glenda G. Anderson
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Patent number: 8977530Abstract: Provided is a method for improving useful substance-producing organisms using metabolic flux analysis, and more particularly a method for improving a host organism producing a useful substance, the method including: calculating a maximum flux value corresponding to the theoretical maximum yield of the useful substance in the metabolic network model of the host organism for producing useful substance, and calculating the optimum value of metabolic flux associated with useful substance production in the metabolic network when the value of cell growth-associated metabolic flux is the maximum under the condition where fermentation data are applied or not applied; selecting metabolic fluxes whose absolute values increase from the range between the maximum value and the optimum value; screening genes associated with the selected metabolic fluxes; and introducing and/or amplifying the selected genes in the host organism. Production of the useful substance can be effectively improved by using the method.Type: GrantFiled: September 15, 2005Date of Patent: March 10, 2015Assignee: Korea Advanced Institute of Science and TechnologyInventors: Sang Yup Lee, Han Min Woo, Hyung Seok Choi