Chromatography Patents (Class 73/61.52)
  • Patent number: 11573211
    Abstract: A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.
    Type: Grant
    Filed: March 23, 2021
    Date of Patent: February 7, 2023
    Inventors: Sylvain Gilles Cormier, Joseph D. Antocci, Francis Patrick Tracey, Charles H. Phoebe, Jr.
  • Patent number: 11567046
    Abstract: The present invention is a data-processing device used for a chromatograph which continuously performs a series of analyses for components in each sample while sequentially introducing a plurality of samples into a column. The device includes: an input section configured to allow for input of information into a schedule table for a plurality of analyses, the schedule table describing an analysis condition including a combination of the values of a plurality of control parameters, the order of execution of the plurality of analyses, and information for identifying a sample to be subjected to each analysis; a chromatogram creating means configured to receive data sequentially collected during two or more analyses and create a joint chromatogram from the data if the two or more analyses have been continuously performed for the same sample according to the schedule table; and a display means configured to display the joint chromatogram.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: January 31, 2023
    Inventors: Futoshi Kurotobi, Toshikazu Minohata
  • Patent number: 11513057
    Abstract: High-throughput methods and systems for using morphological and/or autofluorescence signatures of cells to characterize unknown cell/tissue types within a forensic sample are provided. Machine learning algorithms are used to correlate morphological and/or autofluorescence signatures to characteristics such as cell type.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: November 29, 2022
    Assignee: Virginia Commonwealth University
    Inventor: Christopher Ehrhardt
  • Patent number: 11460455
    Abstract: Method for determining the influence of least a first and a second experimental parameter on a liquid chromatography protocol for purifying one or more target molecules from a sample, comprising the steps: —performing chromatography purifications of the sample at a plurality of different experimental conditions where at least the first and the second experimental parameter each are varied over a predetermined range, each purification being registered as a chromatogram by monitoring an output parameter indicative of the purification result during the purification; and—displaying in a graphical user interface at least a subset of the registered chromatograms as chromatogram-miniatures in an evaluation diagram wherein the position of each displayed chromatogram-miniature is determined by the experimental parameters for the corresponding purification, thereby allowing a user to visually determine trends and the influence of the experimental parameters on the liquid chromatography protocol.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: October 4, 2022
    Assignee: Cytiva Sweden AB
    Inventors: Lena Nyholm, Johan Arthursson, Eva Olsson, Ulrika Ohman
  • Patent number: 11402360
    Abstract: A non-transitory computer readable medium (CRM) storing computer readable program code for monitoring a state of a chromatography apparatus embodied therein that: receives one or more monitoring conditions that each include a determination condition for parameters related to measurements taken using the chromatography apparatus; and displays, in parallel and using a combination operational expression: a first conditional expression based on at least one of the monitoring conditions that make up a first combined conditional expression, wherein the first combined conditional expression is based on a first combined monitoring condition that combines all of the received monitoring conditions, and a second conditional expression based on at least one of the monitoring conditions associated with the first conditional expression.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: August 2, 2022
    Inventors: Riko Tsukamoto, Takashi Inoue
  • Patent number: 11351477
    Abstract: Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column. A method of performing liquid chromatography comprises setting an inlet of a chromatography column to a first temperature using a first temperature control unit in thermal contact with said inlet, setting an outlet of the chromatography column to a second temperature using a second temperature control unit in thermal contact with the outlet, wherein the first temperature is less than the second temperature; and injecting a sample into a liquid stream that flows through the chromatography column after the inlet is set at the first temperature and the outlet is at the second temperature.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: June 7, 2022
    Inventors: Edouard S. P. Bouvier, Joseph Kareh
  • Patent number: 11273390
    Abstract: An apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column wherein the insulating member is formed from a vacuum chamber surrounding the chromatography column. Another apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column, wherein the insulating member includes aerogel. Also described is a method of insulating a chromatography column comprising forming a jacket surrounding the chromatography column, and creating a vacuum chamber in an area between the jacket and the chromatography column.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: March 15, 2022
    Assignee: Waters Technologies Corporation
    Inventors: Edouard S. P. Bouvier, Pamela C. Iraneta, Joseph A. Luongo, Joseph A. Jarrell
  • Patent number: 11073465
    Abstract: A system and method include a resonator device including walls forming a channel, where the walls are shaped to simultaneously confine light in an optical mode and to confine vibration in a mechanical mode, and where the mechanical mode is selected so that vibration in the mechanical mode can couple to the optical mode. A waveguide is coupled with the resonator device for guiding a probe light through the resonator device. An electro-mechanical actuation mechanism provides a mechanical drive force to the resonator device. A photodetector measure light outputted by the waveguide after passing through the resonator device, the outputted light including a modulated version of the probe light based on passing through the resonator device and interacting with a fluid, or a fluid containing a particle, contained by the channel of the resonator device.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: July 27, 2021
    Inventors: Gaurav Bahl, Jeewon Suh
  • Patent number: 10744484
    Abstract: The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group. In some examples, the present disclosure can include a chromatographic system having a chromatographic column having a stationary phase with a chromatographic substrate containing silica, metal oxide, an inorganic-organic hybrid material, a group of block copolymers, or a combination thereof.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: August 18, 2020
    Assignee: Waters Technologies Corporation
    Inventors: Darryl W. Brousmiche, Jacob N. Fairchild, Jason F. Hill, Giorgis Isaac, Michael F. Morris, Kevin D. Wyndham
  • Patent number: 10234461
    Abstract: The present invention relates to simple size exclusion chromatography (SEC) analytical methods useful for the assessment of accurate molecular weight distributions (MWDs) of certain polypeptide mixtures known as glatiramoids. The use of a SEC method based on one or more broad MWD standards furnishes the absolute (not relative) molecular weight distribution profile of complex polypeptide mixtures like, for instance, the glatiramer acetate (GA) polymer.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: March 19, 2019
    Assignee: CHEMI S.P.A.
    Inventors: Andrea Stevenazzi, Andrea Distaso, Aureliano Gaiassi, Eleonora Spuria, Silvana Cappelletti
  • Patent number: 10173148
    Abstract: A pre-heater assembly (90) for pre-heating a fluid, in particular in a fluid separation apparatus (10), wherein the pre-heater assembly (90) comprises a capillary (200) having a lumen and being configured for conducting the fluid, and a thermal coupling body (202) contacting at least part of the capillary (200), having a value of the thermal conductivity in a range between 8 W/(m K) and 100 W/(m K) and being arrangable so that heat generated by a heat source (80) is supplied to the capillary (200) via at least part of the thermal coupling body (202).
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: January 8, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Ansgar Waldbaur, Armin Steinke
  • Patent number: 9643104
    Abstract: A liquid chromatography device includes an adsorption portion that adsorbs one or more analysis components in a specimen, an analysis device that analyzes an analysis component eluted by an eluent, a main feeding device that feeds a first eluent to the adsorption portion, the first eluent eluting an analysis component, a feeding channel in fluid communication with the main feeding device and the adsorption portion, a first retention channel that retains a second eluent, the second eluent differing from the first eluent, an auxiliary feeding device that feeds the second eluent to the first retention channel, and a first switching device that switches the feeding channel to either a first channel or a second channel, the first channel allowing the first eluent to flow from the main feeding device to the adsorption portion, and the second channel allowing the second eluent to flow from the first retention channel to the adsorption portion.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: May 9, 2017
    Assignee: ARKRAY, Inc.
    Inventor: Takeshi Matsubara
  • Patent number: 9539812
    Abstract: In one example, parts to be assembled into a fluid flow structure include: a first part having flat sealing surfaces each surrounding one of multiple first conduit openings; a second part having sealing ridges each surrounding one of multiple second conduit openings; and a single gasket having multiple holes each surrounded on both sides by a flat sealing surface. Each hole in the gasket is positioned to align with one of the first and second conduit openings so that, when the parts are assembled together, each gasket sealing surface contacts a corresponding one of the flat sealing surfaces on the first part or the sealing ridges on the second part and fluid may flow through the holes in the gasket from the conduit openings on one of the parts to the conduit openings on the other part.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: January 10, 2017
    Inventors: Rhonda Lynn Wilson, Daniel D. Dowell
  • Patent number: 9162226
    Abstract: A method and system for a folding microfluidic device comprises creating at least one folding line in a material, forming a plurality of layers of a microfluidic device in said material, and folding the material at the fold lines to create a self-aligned multilayered microfluidic device. The material can comprise a carrier material with an adhesive layer on the top and bottom surfaces.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: October 20, 2015
    Assignees: The United States of America, as represented by the Secretary of Commerce, The National Institute of Standards and Technology
    Inventors: Gregory A. Cooksey, Francisco Javier Atencia-Fernandez
  • Patent number: 9132424
    Abstract: A microchip is provided. The microchip (A) includes a substrate structure including a fluid channel (2) configured to contain a sample solution, wherein the fluid channel is maintained at a pressure lower than atmospheric pressure prior to injection of the sample solution into the fluid channel.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: September 15, 2015
    Inventors: Hidetoshi Watanabe, Yuji Segawa
  • Patent number: 9012660
    Abstract: The present disclosure relates to 5,6,7,8-tetrahydro-6-[N,N-bis[(2-thienyl)ethyl]]amino-1-naphthol, a method for preparing the same, and use of 5,6,7,8-tetrahydro-6-[N,N-bis[(2-thienyl)ethyl]]amino-1-naphthol as a reference compound for determining an impurity in rotigotine or a preparation thereof.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: April 21, 2015
    Assignee: Shandong Luye Pharmaceutical Co., Ltd.
    Inventors: Mina Yang, Yanyan Zhao, Fengmei Zhou, Quingguo Meng, Tao Wang
  • Publication number: 20150099312
    Abstract: Process for normalizing the concentration of at least one analyte in a urine sample, comprising the following steps: a) determining the concentration of at least one analyte; b) determining the concentration of at least one collagen or collagen fragment; c) normalizing the concentration of said at least one analyte relative to the concentration of said at least one collagen or collagen fragment.
    Type: Application
    Filed: October 16, 2014
    Publication date: April 9, 2015
    Inventor: Harald Mischak
  • Publication number: 20150090595
    Abstract: A fitting (200) for providing a fluid connection between a capillary (202) and a fluidic conduit (204) of a fluidic component (30), the fitting (200) comprising a male piece (240) and a female piece (250) for connection with the male piece (240), wherein the male piece (240) comprises a housing (252) with a capillary reception (212) configured for receiving the capillary (202), wherein a part of the capillary (202) being received in the capillary reception (212) is circumferentially covered by a sleeve (214), an elastic biasing mechanism (206) being arranged at least partially within the housing (252), being configured for biasing the capillary (202) against the female piece (250) and being supported by the sleeve (214), and a locking mechanism (208) being arranged at least partially within the housing (252) and being configured for locking the capillary (202) to the fitting (200).
    Type: Application
    Filed: November 15, 2012
    Publication date: April 2, 2015
    Inventors: Claus Lueth, Darijo Zeko
  • Patent number: 8993226
    Abstract: A method of testing for a trisaccharide in milk includes the step of providing a predetermined amount of milk. The method also includes the step of isolating a trisachharide of the milk with a hydride insertion reaction to identify the molecule as phosphorylated. Also included in the method is the step of obtaining a mass spectrum of the isolated milk trisaccharide sample. The method further includes the step of identifying a molecular structure of the isolated milk trisaccharide sample.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: March 31, 2015
    Assignee: BioLogistics. LLC
    Inventor: Michael Madson
  • Publication number: 20150080292
    Abstract: This invention provides new cyclic lipopeptide antibiotic Locillomycin (Locillomycin-A, Locillomycin-B, Locillomycin-C) that display very strong antifungal, antibacterial, antivirus activities in a variety of contexts in vitro; methods of making and using the compounds, wherein Locillomycin-A, Locillomycin-B and Locillomycin-C are derived and purified from the culture of Bacillus subtilis Bs916.
    Type: Application
    Filed: February 26, 2014
    Publication date: March 19, 2015
    Inventor: Chuping Luo
  • Publication number: 20150079624
    Abstract: Methods and protocols of harvesting and processing of Porifera species, specifically sponges, and more specifically fresh water species of Genus Spongilla; testing and storing of the processed Spongilla powder; and manufacturing and packaging of Spongilla-based therapeutic compositions for treating and preventing skin diseases are disclosed. Treatable skin conditions and diseases include without limitation acne vulgaris, rosacea, seborrheic dermatitis, psoriasis, photo-aging and actinic keratosis, acne vulgaris, psoriasis, photo-aging, wounds, scars, and eczema (atopic dermatitis).
    Type: Application
    Filed: November 25, 2014
    Publication date: March 19, 2015
    Inventor: Maria Villani
  • Publication number: 20150068291
    Abstract: The micro-solid phase extraction of haloacetic acids is a procedure that extracts haloacetic acids from aqueous solution using iron-modified rice husk silica as the stationary phase or sorbent. Rice husks provide an excellent source of silica. The sorbent is prepared by incinerating the husks to produce a powder that is treated with 1.0 M nitric acid for 24 hours to produce rice husk silica. The silica is washed with base, cetyltrimethylammonium bromide is added, and then titrated with a 10% Fe3+ solution to pH 5, which forms a gel. The gel is aged, filtered, dried, and calcined to produce a nitrate-free iron-modified rice husk sorbent. The sorbent is then packaged in porous, heat-sealed polypropylene membrane envelopes and used for extraction of HAAs from water. The HAA analytes are desorbed by ultrasonication in methanol for analysis and quantification.
    Type: Application
    Filed: September 11, 2013
    Publication date: March 12, 2015
  • Patent number: 8973427
    Abstract: Embodiments of the present invention are directed to resonating detection devices in which the sample flows through a conduit having a section in which the conduit is grouped or concentrated with the point of maximum movement. An exemplary device includes a primary conduit, at least one first flex section, at least one second flex section and at least one analysis section. The primary conduit cooperates with an energizer for inducing vibration and a programmed calculator for determining a resonant frequency to calculate a mass related parameter of the solution carried therein.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: March 10, 2015
    Assignee: Waters Technologies Corporation
    Inventor: Joseph A. Jarrell
  • Publication number: 20150065437
    Abstract: The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. For example, the peptides may be administered to subjects in need of a mitochondrial-targeted antioxidant.
    Type: Application
    Filed: March 20, 2014
    Publication date: March 5, 2015
    Applicant: Stealth Peptides International, Inc.
    Inventors: Liping Liu, Lawrence Gu
  • Patent number: 8959984
    Abstract: This invention relates to methods for the evaluation and/or quantification of the binding affinity of small molecules or other compounds to target components contained within an analyte, such as target proteins contained within the proteome of a cell or tissue.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: February 24, 2015
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften E.V.
    Inventors: Henrik Daub, Michaela Bairlein, Kirti Sharma, Klaus Godl, Andreas Tebbe, Christoph Weber
  • Publication number: 20150013438
    Abstract: The present invention describes an analytical method for detecting and quantitating poly-sulfated oligosaccharides, including Fondaparinux sodium, using hydrophilic interaction ultra-performance liquid chromatography (HILIC-UPLC) coupled with a charged aerosol detector (CAD) or a mass spectrometer (MS). This analytical method provides in-process control in a total synthesis of highly sulfated oligosaccharides by separation, quantification and mass identification. Systems and conditions utilizing such methods are also provided.
    Type: Application
    Filed: July 11, 2013
    Publication date: January 15, 2015
    Applicant: Scinopharm Taiwan, LTD.
    Inventors: ChungYao Wang, Imin Huang, ChiaYen Wu, YungTe Chiang, Helen Chao
  • Patent number: 8931356
    Abstract: An apparatus for chemical separations includes a first substantially rigid microfluidic substrate defining a first fluidic port; a second substantially rigid microfluidic substrate defining a second fluidic port; and a coupler disposed between the first and second substrates, the coupler defining a fluidic path in fluidic alignment with the ports of the first and second substrates. The coupler includes a material that is deformable relative to a material of the first substrate and a material of the second substrate. The substrates are clamped together to compress the coupler between the substrates and form a fluid-tight seal.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: January 13, 2015
    Assignee: Waters Technologies Corporation
    Inventors: Joseph D. Michienzi, James P. Murphy, Dennis DellaRovere
  • Patent number: 8925374
    Abstract: A detection cell for a chromatography system includes a cell body having an inlet, an outlet, and a counter electrode, a working electrode, a sample flow passageway extending between the inlet and the outlet and in fluid contact with the counter and working electrodes, and a palladium/noble metal reference electrode system. A method of using the detection cell is also described.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: January 6, 2015
    Assignee: Dionex Corporation
    Inventors: Jun Cheng, Petr Jandik, Christopher A. Pohl
  • Publication number: 20140363380
    Abstract: MEX3C deficiency impairs the development of white and brown adipose tissue. Hence the present invention provides, among other things, a method of screening a candidate compound for activity in inhibiting fat deposition in a subject in need thereof and/or treating a condition in a subject in need thereof, comprising: (a) contacting a candidate compound to a cell that expresses MEX3C protein; and then (b) detecting a quantity of expression of the MEX3C protein in the cell; a depression in the expression of MEX3C protein when the candidate compound is contacted thereto as compared to that expressed when the candidate compound is not contacted thereto indicating the compound is active in inhibiting fat deposition and/or treating a condition in a subject in need thereof. Methods of treatment and screening subjects are also described.
    Type: Application
    Filed: March 14, 2014
    Publication date: December 11, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: Baisong Lu, Colin E. Bishop
  • Patent number: 8906692
    Abstract: Disclosed are an apparatus and method for separation analysis of mannose-6-phosphate (M6P) by post-column fluorescence detection method. The apparatus is based on chromatography, and includes a column with a solid phase having affinity for phosphate, a flow path for the eluate, a heater installed on the flow path for M6P and a basic amino acid to react by heating the eluate in the flow path, and a fluorescence detector installed downstream of the heater for continuously irradiating the eluate with excitation light and measuring the intensity of the emission, and may include in the flow path a supply channel for addition of a basic amino acid between the column and the heater. The method is characterized in that it uses the apparatus and a second mobile phase consisting of a second buffer containing phosphate of predetermined concentration and adjusted to a predetermined pH.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: December 9, 2014
    Inventor: Tetsuo Yokoyama
  • Patent number: 8901484
    Abstract: The present invention relates to a method for the quantitative determination of an impurity present in a peptide product, wherein the impurity cannot be separated from other impurities or the main product. The method particularly involves the use of high resolution mass spectrometry (MS) detection with or without high performance liquid chromatography (HPLC). The method can be used for the investigation of the quality of peptides and proteins, particularly of pharmaceutical peptides and proteins.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: December 2, 2014
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Martin Vogel, Werner Mueller
  • Publication number: 20140338429
    Abstract: The present invention provides methods of separating, profiling and analyzing molecular species contained within a biological sample using a high purity chromatographic material (HPCM) comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifiers with the proviso that when the ionizable modifier does not contain a Zwitterion, the ionizable modifier does not contain a quaternary ammonium ion moiety.
    Type: Application
    Filed: May 31, 2012
    Publication date: November 20, 2014
    Applicant: Waters Technologies Corporation
    Inventors: Giorgis Isaac, Stephen McDonald, Alan Millar, Kenneth Fountain, John Shockcor
  • Patent number: 8889423
    Abstract: A method for analyzing a binding ability of protein to a compound, comprising the steps of (a) fractionating a first group of isotope-labeled proteins into plural fractions using a carrier having the compound immobilized thereon; (b) fractionating a second group of proteins into one or plural fractions using a carrier having the compound immobilized thereon; (c) adding an amount of at least one fraction obtained in step (b) to each of the fractions obtained in step (a); (d) analyzing the fractions obtained in step (c) with mass spectrometry; and (e) based on the mass spectrometry information, obtaining, regarding each fraction, an intensity ratio between a peak derived from a protein in the fraction obtained in step (a) and a peak derived from a protein in the fraction obtained in step (b), and comparing degrees of the binding ability of the plural kinds of proteins to the compound.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: November 18, 2014
    Assignee: Eisai R & D Management Co., Ltd.
    Inventors: Yoshiya Oda, Hiroyuki Katayama
  • Publication number: 20140287442
    Abstract: The invention comprises a method for determining degree of modified potency of a bipathic medicament. A bipathic medicine is a medicament comprising a therapeutic component and a homeopathic component, wherein the homeopathic component has some physical, chemical or biological affect on the therapeutic component and/or the pharmacological efficacy thereof. An analytical measurement of at least one characteristic parameter of the therapeutic form is made prior to its interaction with the activated-potentiated form. The same analytical measurement(s) are made and after interaction between the therapeutic and activated-potentiated forms. This data is used to confirm the presence of any modified potency is caused by the presence of molecular form in the activated-potentiated form.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 25, 2014
    Inventor: Oleg Iliich Epshtein
  • Publication number: 20140287034
    Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
    Type: Application
    Filed: May 23, 2014
    Publication date: September 25, 2014
    Applicants: Ironwood Pharmaceuticals, Inc., Forest Laboratories Holdings Limited
    Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
  • Publication number: 20140260534
    Abstract: An improved biocompatible filter for use in liquid chromatography systems such as HPLC or UHPLC The present disclosure addresses the problem of particles bypassing a filter in a liquid chromatography application by design features in the interface between the frit filter and ring that form an improved seal between the ring and frit and prevent leakage around the filter in high measure chromatography. Design features also include frit filters with an internal particle size gradient for pre-column separation activity during filtration.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 18, 2014
    Applicant: IDEX Health & Science LLC
    Inventors: Mark Hahn, Eric Beemer
  • Publication number: 20140260563
    Abstract: This invention provides aqueous-compatible, polar-embedded reversed-phase stationary phase compositions, devices and systems comprising the stationary phases as well as methods of producing these compositions using epoxide ring-opening reactions. Also provided are methods of using the stationary phases of the invention in separations.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Inventors: Xiaodong LIU, Liang CAO, Christopher A. POHL
  • Publication number: 20140274931
    Abstract: The present description discloses a novel biologically active ingredient of manuka honey. Specially, the present description discloses a compound represented by the following formula. In this formula, each of R1, R2 and R3 independently represents a hydrogen atom or optionally substituted C1-4 alkyl group, m represents an integer from 1 to 3, each of R4-m, R5-m and R6-m independently represents a hydrogen atom or optionally substituted C1-4 alkyl group, and each of R7, R8, R9 and R10 independently represents a hydrogen atom or optionally substituted C1-4 alkyl group.
    Type: Application
    Filed: October 15, 2012
    Publication date: September 18, 2014
    Inventor: Yoji Kato
  • Publication number: 20140274660
    Abstract: A fabric phase sorptive extractor (FPSE) is a sampling device where a flexible fabric is coated with at least one sol-gel derived film that includes at least two of a metal oxide portion, a siloxy portion, and an organic portion, where the gel has at least some amorphous portions. The FPSE is flexible such that it can be used in an extended form or draped over a solid surface to contact a gaseous, liquid, or solid environment and can be manipulated for placement in a container where the absorbed analyte can be removed from the FPSE for instrumental analysis. The FPSE can have specific functionalities that bind to specific analytes or can provide a general sorbent medium for extraction of a wide range of analytes, such that the sampling device can be employed for sampling analytes with biological, environmental, food, pharmaceutical, bio-analytical, clinical, forensic, toxicological, national security, public health, and/or safety implications.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 18, 2014
    Inventors: Abuzar Kabir, Kenneth G. Furton
  • Publication number: 20140260562
    Abstract: A method of measuring digestibility of food proteins is disclosed, the method comprising using protease enzymes in combination with an ultra filtration step.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Inventor: Safa MOTLAGH
  • Publication number: 20140196523
    Abstract: The present disclosure relates to 5,6,7,8-tetrahydro-6-[N,N-bis[(2-thienypethyl]]amino-1-naphthol, a method for preparing the same, and use of 5,6,7,8-tetrahydro-6-[N,N-bis[(2-thienypethyl]]amino-1-naphthol as a reference compound for determining an impurity in rotigotine or a preparation thereof.
    Type: Application
    Filed: August 6, 2012
    Publication date: July 17, 2014
    Inventors: Mina Yang, Yanyan Zhao, Fengmei Zhou, Quingguo Meng, Tao Wang
  • Publication number: 20140194304
    Abstract: Antibody-free processes are disclosed that provide accurate quantification of a wide variety of low-abundance target analytes in complex samples. The processes can employ high-pressure, high-resolution chromatographic separations for analyte enrichment. Intelligent selection of target fractions may be performed via on-line Selected Reaction Monitoring (SRM) or off-line rapid screening of internal standards. Quantification may be performed on individual or multiplexed fractions. Applications include analyses of, e.g., very low abundance proteins or candidate biomarkers in plasma, cell, or tissue samples without the need for affinity-specific reagents.
    Type: Application
    Filed: January 8, 2013
    Publication date: July 10, 2014
    Inventors: Tujin Shi, Weijun Qian, Thomas L. Fillmore, Xuefei Sun, Richard D. Smith
  • Patent number: 8741151
    Abstract: The scale inhibitors in a variety of aqueous systems, or a part or sample thereof, also including one or more dissolved interfering ions, are separated therefrom and analyzed, such scale inhibitors comprising a polymer containing at least one anionic functional group, e.g., a strong acid functional group or a phosphonate or phosphate ester, and such analysis including treating these aqueous systems with a cationic substrate or a free cation.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: June 3, 2014
    Assignee: Rhodia UK Limited
    Inventors: Mike Hails, Chris Jones
  • Patent number: 8742331
    Abstract: Imidazolium-based dicationic liquid salts and methods of using such imidazolium-based dicationic liquid salts in techniques such as ESI-MS are provided.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: June 3, 2014
    Assignee: Sigma-Aldrich, Co.
    Inventor: Daniel W. Armstrong
  • Patent number: 8734628
    Abstract: Technologies are generally described for microfluidic channel devices. Some example devices may include a substrate having a substrate surface, with an array of drive electrode assemblies disposed upon the substrate surface. The drive electrode assemblies may be arranged along a path. Each drive electrode assembly may include one or more of a drive electrode layer, a dielectric layer and/or a stationary phase layer. The device may further include a plate including a plate surface. The device may further include a reference electrode configured on the plate surface to face the stationary phase layer of the drive electrode assemblies and separated from the substrate surface by a distance. The device may further include a voltage source effective to output a voltage potential, the voltage source configured in communication with the drive electrode assembly and the reference electrode. The device may further include an electrode selector effective to control the voltage source.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: May 27, 2014
    Assignee: Empire Technology Development, LLC
    Inventor: Vincenzo Casasanta, III
  • Patent number: 8728828
    Abstract: The present invention relates to a separation matrix comprised of porous particles to which antibody-binding protein ligands have been immobilized, wherein the ligand density is in the range of 5.0-10 mg/ml; the gel phase distribution coefficient of the particles expressed as Kav for a dextran of size 110 kDa is above 0.65 and the median particle diameter is between 65-84 ?m. The carbohydrate material is preferably highly cross-linked agarose.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: May 20, 2014
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Hans Berg, Hans Johansson, Gunnar Malmquist, Per-Mikael Aberg
  • Publication number: 20140130580
    Abstract: A fluidic connection system may comprise a port which includes a capillary tube receptacle with an end seal face and a threaded wall. The fluidic connection system may also comprise a capillary tube that includes a front end face for sealingly abutting against the end seal face of the port. On the capillary tube, a flange may be affixed at a distance from the front end face of the capillary tube. The fluidic connection system may further comprise a fitting nut that includes an axial hole to allow the capillary tube to pass therethrough and a matching threaded wall corresponding to the threaded wall of the port. The fitting nut may be slidably coupled with the capillary tube behind the flange. The distance at which the flange is affixed may be predetermined such that when the flange is pushed forward by the fitting nut, the front end face of the capillary tube abuts directly against the end seal face of the port.
    Type: Application
    Filed: November 12, 2012
    Publication date: May 15, 2014
    Inventors: Michael John MCADAMS, Milton LIU, George N. PROPER
  • Patent number: 8721892
    Abstract: Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: May 13, 2014
    Assignee: California Institute of Technology
    Inventors: Chi-Yuan Shih, Yu-Chong Tai, Jun Xie, Darron K. Young, Po-Jui Chen
  • Publication number: 20140116118
    Abstract: Indole-3-propionic acid as a marker and for treatment for Huntington Disease.
    Type: Application
    Filed: November 27, 2013
    Publication date: May 1, 2014
    Inventor: Wayne R. Matson
  • Patent number: 8702983
    Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: April 22, 2014
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Klaus Gebauer