Abstract: Certain embodiments described herein are directed to systems and methods that can be used to analyze species in a fluid stream. In some configurations, a sorbent tube effective to directly sample aromatics and/or polyaromatics in a fluid stream is described.

Abstract: Systems and methods are described for rapid throughput of samples from a plurality of sample sources to a nebulizer for analysis, such as a sample analysis via ICP-MS. A system embodiment can include, but is not limited to, a valve in fluid communication with a fluid transfer line to receive a plurality of samples from a plurality of sample sources from an autosampler unit and direct the sample into a valve channel; a first pump to draw sample into the valve channel, a sensor positioned adjacent a nebulizer to detect respective samples of the plurality of samples and generate one or more signals in response thereto; a second pump to push the sample from the valve channel to the nebulizer; and a controller configured to coordinate operation of the first pump, the second pump, and the valve based at least on the one or more signals.

Abstract: A liquid chromatography system includes a separation column, a trap column, and a first switching valve. The first switching valve is adapted to assume a first switching position for bringing a sample into the trap column in a first flow direction. The switching valve is also adapted to assume a second switching position for fluidly connecting the trap column with the separation column and providing a flow from the trap column to the separation column in a second flow direction. The second flow direction is opposite to the first flow direction. The first switching valve is adapted to assume a third switching position for fluidly connecting the trap column, with the separation column and providing a flow from the trap column to the separation column in the first flow direction.

Abstract: The present disclosure relates to a method and a solid phase microextraction sampling instrument for inserting into or through a solid or semisolid material to extract a component of interest from a sample, comprising a support structure at least partially coated with an extraction phase for extracting the component of interest, a protrusion that shields the coating during insertion, where the distances within a cross-sectional plane of the sampling instrument are greater than or equal to the corresponding distances in all of the cross-sectional planes located between the cross-sectional plane of interest and the insertion end of the sampling instrument. The present disclosure also discusses methods of making the instrument, desorption chambers, and methods for desorbing a component of interest from the instrument.

Abstract: A sample injector configured to introduce a sample fluid into a mobile phase, wherein the mobile phase is to be driven by a mobile phase drive through a separation unit for separating compounds of the sample fluid in the mobile phase, wherein the sample injector comprises a metering device being operable for displacing fluid and for intaking a metered amount of the sample fluid into the sample injector, an injector valve being switchable for operating the sample injector selectively in a sample intake mode in which the metering device is operable to intake the sample fluid from a sample container, or a separation mode in which intaken sample fluid is driven between the mobile phase drive and the separation unit for separating the compounds, and a flow direction controller configured for defining an enabled flow direction of fluid displaced by the metering device and for defining a disabled flow direction.

Abstract: The invention generally relates to a connector for fluid chromatography, such as gas chromatography and liquid chromatography, having a female assembly including a receiving member being designed and configured to receive, and releasably interlock with, a male assembly. The connector is particularly suited for high performance liquid chromatography (HPLC) applications.

Abstract: A fluid processing device (10) for processing fluid, wherein the fluid processing device (10) comprises a first fluid drive unit (20) configured for driving a first fluid along a first flow path (85), a second fluid drive unit (20?) configured for driving a second fluid along a second flow path (86), and a fluidic switch (90) fluidically coupled to the first flow path (85) and to the second flow path (86) and configured for being switchable for transferring first fluid from the first flow path (85) into the second flow path (86) without interruption of fluid flow along at least one of the first flow path (85) and the second flow path (86).

Abstract: Provided are two-dimensional chromatography systems and methods for separating and/or analyzing complex mixtures of organic compounds. In particularly, a two-dimensional reversed-phase liquid chromatography (RPLC)-supercritical fluid chromatography (SFC) system is described including a trapping column at the interface which collects the analytes eluted from the first dimension chromatography while letting the RPLC mobile phase pass through. The peaks of interest from the RPLC dimension column are effectively focused as sharp concentration pulses on the trapping column, which is subsequently injected onto the second dimension SFC column. The system can be used for simultaneous achiral and chiral analysis of pharmaceutical compounds. The first dimension RPLC separation provides the achiral purity result, and the second dimension SFC separation provides the chiral purity result (enantiomeric excess).

Abstract: A strain of marine oil degrading bacteria, compounds obtained by fermentation and their uses are published. The name is Alcanivorax dieselolei T6-6, with preservation Number: CGMCC NO: 9033. It belongs to ?-proteobacteria, oceanospirillales, alkane degrading bacteria branch, alcanivorax category and diesel alcanivorax species. The said bacteria can be used to degrade and remove petroleum hydrocarbon, control environmental pollution, produce surfactants, reduce surface tension of water, and for other purposes; a compound can be isolated from secondary metabolites after fermentation, one of which is dieselolei T6-6, 2-amino-6-(N-2-carbonyl-4-tridecyl-cyclobutane) hexanoic acid, and it is a kind of lysine ester. The compound has emulsifying activity on different organics, antibacterial effects against Gram-positive bacteria and fungus, and a better cytotoxic activity.

Abstract: The invention provides a method for simple, rapid and inexpensive analysis of drugs such as nicotine and other drugs which are accumulated in biological samples of addictive drugger of tobacco, stimulant drug and the like. The method comprises the steps of introducing the biological sample into an injection needle, inserting the needle into an injector of a chromatograph and injecting a carrier into the needle to conduct chromatography treatment.

Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

Abstract: The invention relates to a sampler for providing a sample for high-performance liquid chromatography, in which a volume of liquid to be taken up into a cylinder can be aspirated by means of a first drive and can be compressed to a high pressure level by means of a second drive independent of the first drive or can be decompressed from this level in a controlled manner.

Abstract: Automated sample injection apparatus, multiport valves, and chromatography systems containing an automated sample injection apparatus and/or a multiport valve are disclosed. Methods of making and using automated sample injection apparatus and multiport valves within chromatography systems are also disclosed.

Abstract: A method and system for continuous measurement chromatograph involves stochastically modulating a system variable. The sample can be introduced into a chromatography column. The sample introduction can be modulated stochastically. The sample output from the column can be detected and processed with the stochastic input to provide a sample analysis.

Abstract: Disclosed herein is a sample introducing apparatus which is designed such that the analytical flow path runs from the needle to the separation column without the flow path switching means placed at the downstream side of the needle. This design reduces dead volume, which in turn reduces the diffusion of the sample injected into the analytical flow path. Moreover, the absence of the flow path switching means at the downstream side of the needle to inject a sample into the analytical flow path eliminates connection of the pipe with the flow path switching means. This prevents the sample from remaining in the connecting part, thereby reducing sample carry-over and improving the accuracy of analysis.

Abstract: The subject technology is directed to a CO2-based system and method for rapid determination of the levels and/or the presence or absence of polycyclic aromatic hydrocarbons (PAHs).

Abstract: The present invention relates to the use of a microporous organogel for the capture of fluids by adsorption and/or for the controlled release of fluids after solubilization. The fluids are, in particular, air or water pollutants or volatile substances. The invention also relates to the use of a microporous organogel in a process for analyzing the captured fluids. The invention also relates to any fluid sensor by moulding of a microporous organa gel.

Abstract: A fluid supply system (150) configured for supplying fluids, the fluid supply system (150) comprising a fluid packet supply unit (180) configured for controlling supply of a sequence (250) of fluid packets (222 to 230), the fluid packets (222 to 230) comprising a packet of first fluid (223) and a packet of second fluid (225), wherein the first fluid and the second fluid are media being prone to a phase separation upon direct interaction between the packet of first fluid (223) and the packet of second fluid (225), and a phase separation inhibiting unit (190) configured for inhibiting phase separation by inserting an intermediate fluid packet (224) between the packet of first fluid (223) and the packet of second fluid (225) to 230 to 230

Abstract: Constant calibration methods and apparatuses for analytical devices that are located in remote positions in order to allow for reliable and automated measurements of various contaminants within water or other liquid samples. The proposed calibration systems allow for certain methods to measure total amounts of certain trihalomethane and haloacetic acid contaminants, at least, in drinking water samples from such remote locations, through the utilization of a standard addition introduction of known concentrations of such contaminant compounds within target samples, followed by separation through a capillary membrane sampling device and measurement of such different contaminants via flow injection analysis (FIA). In such a manner, the on-line, remote system provides the necessary reliability for a water utility or like entity on which to base any further needed water treatment activities without having to perform such measurements in a distinct lab setting.

Abstract: A multi-mode injection valve includes a stator having an outer stator face and an inner stator face; a plurality of fluid ports in the outer stator face; a plurality of fluid orifices in the inner stator face, the fluid orifices disposed in fluid communication with the fluid ports, respectively; a rotor having a rotor surface engaging the inner stator face of the stator; a plurality of rotor grooves in the rotor surface of the rotor, each of the rotor grooves adapted for fluid communication with a pair of the fluid orifices depending upon a rotational or angular position of the rotor with respect to the stator; and an actuator unit engaging the rotor, the actuator unit adapted to rotate the rotor relative to the stator.

Abstract: A device for sampling fluid from an earth formation is disclosed. The device includes: an inlet port disposable in fluid communication with the fluid in a borehole; an injector including an injection chamber in fluid communication with the inlet port, the injector configured to receive a portion of the fluid and direct the fluid toward an analysis unit for analyzing constituent materials in the fluid; and a high pressure valve configured to admit the portion of the fluid at a borehole pressure and release the portion of the fluid into the injector, the portion having a volume that is less than or equal to about one microliter. A system and method for analyzing constituents of fluid in a borehole in an earth formation is also disclosed.

Abstract: Methods and systems for analyzing ratios of analytes within a flowing sample are provided. The flowing sample can be processed in real-time to determine a time interval over which a predetermined amount of a group of analytes passes by a fixed point in a flow cell. The predetermined amount can be routed to a sample container for future processing. The sample can comprise diluted blood and the analytes can comprise a component of hemoglobin, such as A1c, and the total amount of hemoglobin, of which the predetermined amount is metered.

Abstract: An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC with refractive index (RI) detection; the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol.

Abstract: Methods and apparatus for controlling interdetector band broadening during the analysis of a sample injected into a chromatography system. A column flow is diluted with a dilution flow after the sample exits the chromatography system, and the diluted sample is analyzed by one or a combination of analysis instruments such as a light scattering detector, refractive index detector, an ultraviolet absorption detector.

Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.

Abstract: Devices, systems, and methods for the collection of biological samples. In at least one exemplary embodiment, a device comprises a collection medium having top and bottom surfaces and a predetermined size and shape, the top surface comprising a position marker and at least one binding site operable to bind a biological sample, a protective facing substantially impermeable to the biological sample, the protective facing coupled to the top surface of the collection medium and having a size and shape substantially similar to the predetermined size and shape of the collection medium. The protective facing being sized and shaped to define a first void positioned to allow for the transfer of the biological sample through the protective facing and onto the at least one binding site of the collection medium, and a second void positioned to expose the position marker for alignment of the collection medium.

Abstract: An apparatus for chemical separations includes a first substantially rigid microfluidic substrate defining a first fluidic port; a second substantially rigid microfluidic substrate defining a second fluidic port; and a coupler disposed between the first and second substrates, the coupler defining a fluidic path in fluidic alignment with the ports of the first and second substrates. The coupler includes a material that is deformable relative to a material of the first substrate and a material of the second substrate. The substrates are clamped together to compress the coupler between the substrates and form a fluid-tight seal.

Abstract: A multiple loop sample introduction system comprises a valve assembly including a sample collection valve and a sample introduction valve. First and second sample loops are in fluid communication with the sample collection valve and the sample introduction valve to receive aliquots of liquid samples to be introduced into a nebulizer. The valve assembly is operable to port a first aliquot into the first sample loop, while porting a second aliquot received in the second sample loop for introduction into the nebulizer.

Abstract: Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis. The liquid eluent is pumped through a heated nebulizer to create a high-speed jet of solute containing liquid and solvent vapor. This jet is directed circumferentially inside a hot cylindrical cavity. Centrifugal force causes the larger liquid droplets to travel along the outer diameter of the cavity. The cavity surface is heated to cause the droplets to film boil. Film boiling reduces droplet contact with the cavity surface thereby retaining the solute in the droplets. The solute temperature is limited by controlling the pressure into which the solvent evaporates from the droplets.

Abstract: A micromachined flow cell (100), comprising a substrate (102), and a freestanding tube (104) delimiting a fluidic conduit (800) therein and being integrally formed from material of the substrate (102).

Abstract: The present invention provides a rack for holding sample vials comprising: (i) a solid base; (ii) an upwardly extending wall around the perimeter of said base; (iii) a plurality of means for supporting a plurality of vials, each means for supporting one vial; and (iv) a means for draining liquid from said rack.

Abstract: A liquid sampling system includes a liquid sampling valve for transferring a liquid sample from a primary stream to a secondary stream. The liquid sampling valve includes a rotor having a movable shuttle that is in selective fluid communication with the primary stream or the secondary stream. The rotor shuttle passes through a discharge station prior to completion of the valve cycle to discharge contaminants prior to re-exposure to the primary stream.

Abstract: Disclosed are an apparatus and method for separation analysis of mannose-6-phosphate (M6P) by post-column fluorescence detection method. The apparatus is based on chromatography, and includes a column with a solid phase having affinity for phosphate, a flow path for the eluate, a heater installed on the flow path for M6P and a basic amino acid to react by heating the eluate in the flow path, and a fluorescence detector installed downstream of the heater for continuously irradiating the eluate with excitation light and measuring the intensity of the emission, and may include in the flow path a supply channel for addition of a basic amino acid between the column and the heater. The method is characterized in that it uses the apparatus and a second mobile phase consisting of a second buffer containing phosphate of predetermined concentration and adjusted to a predetermined pH.

Abstract: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.

Abstract: A sampler (10), in particular for use in testing the dissolution behavior of pharmaceutical products, wherein the sampler (10) comprises: a vial holder (20) for accommodating a plurality of vials (22a, 22b); a sampling needle assembly (30) with a plurality of sampling needles, wherein the sampling needle assembly (30) and the vial holder (20) may be moved relative to one another in such a way that the sampling needles of the sampling needle assembly (30) may be inserted into the vials of the vial holder (20); and a pump unit (40) with a plurality of diaphragm pumps (42a, 42b) which are designed to convey a fluid via the sampling needle assembly to the vials in the vial holder (20) and to withdraw a fluid therefrom.

Abstract: A sample injector for liquid chromatography includes an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

Abstract: Certain embodiments described herein are directed to systems and methods that can be used to analyze species in a fluid stream. In some configurations, a sorbent tube effective to directly sample aromatics and/or polyaromatics in a fluid stream is described.

Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

Abstract: A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes. The high performance liquid chromatography method of the present invention is suitable for the separation of diastereomers of the same metal complexes. Also provided is a chiral high performance liquid chromatography method to separate enantiomers of metal complexes. Superoxide dismutase mimetic compounds are also provided.

Abstract: An analysis method is achieved in which pressure variation resulting from sample injection or passage switching by an autosampler does not exert an influence on the control of a liquid transfer pump. The liquid chromatograph analysis method comprises the steps of: transferring two or more types of eluents while changing a mixing ratio between the eluents; adjusting an amount of the transferred liquid within a predetermined time in a passage for the eluent transferred; injecting a sample in the passage; supplying to a separation column the eluent into which the sample is injected; separating a target component in the sample; and detecting the target component thus separated. In this method, control is exercised so as to synchronize a liquid transfer cycle of the eluent with the sample injecting operation and to implement the sample injecting operation at a timing rather than the pressure obtaining time.

Abstract: The dispersibility of soot in a lubricant formulation containing a dispersant is evaluated by (a) preparing a dispersion of carbon black in the lubricant formulation; (b) depositing a sample of the dispersed carbon black from step (a) onto a planar chromatography medium; (c) subjecting the sample of (b) to chromatographic conditions and (d) evaluating the extent of migration of the carbon black by comparing the density of darkening due to carbon black at pre-defined locations along the chromatography medium. The liquid mobile chromatography phase comprises a mixture of a liquid non-aromatic hydrocarbon portion having viscosity and boiling point less than that of an oil of lubricating viscosity; and an oil component comprising an oil of lubricating viscosity and the dispersant or dispersants that are also contained within the lubricant formulation.

Abstract: This analysis method includes: subjecting a sample solution of a dye-containing sample in an organic solvent to normal-phase liquid chromatography to separate the sample solution and detect separated components. The normal-phase liquid chromatography involves (B1) using a separation column filled with a column packing material which is prepared by modifying a base material with a polar modifying group, and (B2) using as an eluent a polar organic solvent containing an acid.

Abstract: A mixing device for use in a chromatography system, the device includes an exterior housing having a first end and a second end and a hydraulic flow connector at the first end of the exterior housing. A cartridge including a chamber is enclosed within the exterior housing. The chamber has at least one wall defining an interior volume having a shape, wherein the shape of the interior volume creates a turbulent flow condition to mix at least two fluids and provide flow through the cartridge during operation of the chromatography system. The chamber also retains the sample, thereby ensuring that the sample is focused in the chamber such that a more narrow bolus of sample enters the chromatography column.

Abstract: A sample injector for liquid chromatography includes an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

Abstract: Method for verification of age-depth relationships of rocks in sedimentary basins by reconstructing the subsistence rate of samples, in which, by determining the precipitation depth and precipitation temperature of a carbonate precipitation, wherein by determining the precipitation depth and the precipitation temperature of the carbonate precipitation in the geological-history-determining sedimentary rocks, from which a sample is taken, a set point is fixed.

Abstract: An method for optimizing operation of an autosampler coupled to a liquid chromatography (LC) system comprises: reading, from electronic memory storage, a pre-injection time corresponding to the time required for the autosampler to perform operations preparatory to injecting a sample; calculating an autosampler delay time from the pre-injection time and from a sample analysis time; performing the autosampler operations preparatory to injecting the sample after delaying said autosampler operations for the autosampler delay time; measuring a time value for the preceding performing of autosampler operations; replacing the pre-injection time value stored on the electronic memory storage with the measured time value for the preceding performing of autosampler operations if the measured value is greater than the pre-injection time value stored on the electronic memory storage; and injecting the sample from the autosampler into the LC system after receipt of a signal from the LC system by the autosampler.

Abstract: In injecting a sample sucked into a sample loop in an autosampler from an injection needle into an analytical flow path via an injection port by a mobile phase, a sending flow rate of the mobile phase is reduced from a certain flow rate determined in an analysis condition to reduce pressure applied on a joint section between the needle and the injection port to thereby reduce the sample remaining in the injection port.

Abstract: An apparatus for use in a chromatography system includes a microfluidic substrate having a fluidic channel configured as an analytical chromatographic column and a fluidic port on one side of the microfluidic substrate. The fluidic port opens at a head end of the analytical chromatographic column. A dried blood spot (DBS) collection device holds one or more dried biological samples. The DBS collection device is directly coupled to the microfluidic substrate whereby one of the biological samples is placed into fluidic communication with the fluidic channel of the microfluidic substrate and an extraction of that biological sample flows toward the head end of the analytical chromatographic column. A diluent source fluidically coupled to the fluidic port supplies a solvent to the head end of the analytical column to dilute the extracted biological sample before the biological sample flows into the analytical chromatographic column.

Abstract: A blood collection module includes a blood collection container that is coupled with a blood alcohol concentration detection device including an alcohol detection sensor having a detection probe that inhales an alcohol gas, and on one surface of which an inserting portion that is inserted by a detection probe of a blood alcohol concentration detection device is formed and on an outer surface of which blood inlet holes through which blood flows in are formed; and an absorption member that is provided in the blood collection container, to thus absorb examinee's blood that is introduced through the blood inlet holes, in which an alcohol gas generated from the blood absorbed by the absorption member is introduced into the alcohol detection sensor through the detection probe.

Abstract: A fluorescence spectrophotometer according to the present invention includes: a light source 1; a sample cell 3; an excitation-side light-dispersing system 2 for dispersing a light from the light source 1 and for casting a desired wavelength of light into the sample cell 3; an emission-side light-dispersing system 4 for dispersing a light emitted from the sample cell 3, the emission-side light-dispersing system 4 being located off an optical path of a transmitted light exiting from the sample cell 3 after being cast from the excitation-side light-dispersing system 2 into the sample cell 3; and a photodetector 5 capable of detecting, among the light from the emission-side light-dispersing system 4, an emission light having the same wavelength as the light cast from the excitation-side light-dispersing system 2 into the sample cell 3.