Including Sampling, Sample Handling, Or Sample Preparation Patents (Class 73/61.55)
  • Patent number: 10746710
    Abstract: Certain embodiments described herein are directed to systems and methods that can be used to analyze species in a fluid stream. In some configurations, a sorbent tube effective to directly sample aromatics and/or polyaromatics in a fluid stream is described.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 18, 2020
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Lee Marotta
  • Patent number: 10741374
    Abstract: Systems and methods are described for rapid throughput of samples from a plurality of sample sources to a nebulizer for analysis, such as a sample analysis via ICP-MS. A system embodiment can include, but is not limited to, a valve in fluid communication with a fluid transfer line to receive a plurality of samples from a plurality of sample sources from an autosampler unit and direct the sample into a valve channel; a first pump to draw sample into the valve channel, a sensor positioned adjacent a nebulizer to detect respective samples of the plurality of samples and generate one or more signals in response thereto; a second pump to push the sample from the valve channel to the nebulizer; and a controller configured to coordinate operation of the first pump, the second pump, and the valve based at least on the one or more signals.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: August 11, 2020
    Assignee: ELEMENTAL SCIENTIFIC, INC.
    Inventor: Daniel R. Wiederin
  • Patent number: 10690639
    Abstract: A liquid chromatography system includes a separation column, a trap column, and a first switching valve. The first switching valve is adapted to assume a first switching position for bringing a sample into the trap column in a first flow direction. The switching valve is also adapted to assume a second switching position for fluidly connecting the trap column with the separation column and providing a flow from the trap column to the separation column in a second flow direction. The second flow direction is opposite to the first flow direction. The first switching valve is adapted to assume a third switching position for fluidly connecting the trap column, with the separation column and providing a flow from the trap column to the separation column in the first flow direction.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: June 23, 2020
    Assignee: Dionex Softron GMBH
    Inventors: Thomas Wachinger, Christoph Hollnagel
  • Patent number: 10545073
    Abstract: The present disclosure relates to a method and a solid phase microextraction sampling instrument for inserting into or through a solid or semisolid material to extract a component of interest from a sample, comprising a support structure at least partially coated with an extraction phase for extracting the component of interest, a protrusion that shields the coating during insertion, where the distances within a cross-sectional plane of the sampling instrument are greater than or equal to the corresponding distances in all of the cross-sectional planes located between the cross-sectional plane of interest and the insertion end of the sampling instrument. The present disclosure also discusses methods of making the instrument, desorption chambers, and methods for desorbing a component of interest from the instrument.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: January 28, 2020
    Assignee: JP SCIENTIFIC LIMITED
    Inventors: Janusz Boleslaw Pawliszyn, Justen James Poole, Jonathan James Grandy, Barbara Bojko
  • Patent number: 10473632
    Abstract: A sample injector configured to introduce a sample fluid into a mobile phase, wherein the mobile phase is to be driven by a mobile phase drive through a separation unit for separating compounds of the sample fluid in the mobile phase, wherein the sample injector comprises a metering device being operable for displacing fluid and for intaking a metered amount of the sample fluid into the sample injector, an injector valve being switchable for operating the sample injector selectively in a sample intake mode in which the metering device is operable to intake the sample fluid from a sample container, or a separation mode in which intaken sample fluid is driven between the mobile phase drive and the separation unit for separating the compounds, and a flow direction controller configured for defining an enabled flow direction of fluid displaced by the metering device and for defining a disabled flow direction.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: November 12, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Daniel Thielsch, Thomas Ortmann
  • Patent number: 10335793
    Abstract: The invention generally relates to a connector for fluid chromatography, such as gas chromatography and liquid chromatography, having a female assembly including a receiving member being designed and configured to receive, and releasably interlock with, a male assembly. The connector is particularly suited for high performance liquid chromatography (HPLC) applications.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: July 2, 2019
    Inventors: Nicolai Bache, Christoph Gebhardt, Ole Bjeld Hoerning, Ralph Kikillus, Frank Hirmer, Peter Aagaard Nielsen
  • Patent number: 10281058
    Abstract: A fluid processing device (10) for processing fluid, wherein the fluid processing device (10) comprises a first fluid drive unit (20) configured for driving a first fluid along a first flow path (85), a second fluid drive unit (20?) configured for driving a second fluid along a second flow path (86), and a fluidic switch (90) fluidically coupled to the first flow path (85) and to the second flow path (86) and configured for being switchable for transferring first fluid from the first flow path (85) into the second flow path (86) without interruption of fluid flow along at least one of the first flow path (85) and the second flow path (86).
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: May 7, 2019
    Assignee: AGILENT TECHNOLOGIES
    Inventors: Konstantin Shoykhet, Klaus Witt, Stephan Buckenmaier, Dwight Stoll
  • Patent number: 10101306
    Abstract: Provided are two-dimensional chromatography systems and methods for separating and/or analyzing complex mixtures of organic compounds. In particularly, a two-dimensional reversed-phase liquid chromatography (RPLC)-supercritical fluid chromatography (SFC) system is described including a trapping column at the interface which collects the analytes eluted from the first dimension chromatography while letting the RPLC mobile phase pass through. The peaks of interest from the RPLC dimension column are effectively focused as sharp concentration pulses on the trapping column, which is subsequently injected onto the second dimension SFC column. The system can be used for simultaneous achiral and chiral analysis of pharmaceutical compounds. The first dimension RPLC separation provides the achiral purity result, and the second dimension SFC separation provides the chiral purity result (enantiomeric excess).
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: October 16, 2018
    Assignee: GENENTECH, INC.
    Inventors: Cadapakam Venkatramani, Mohammad Al-Sayah
  • Patent number: 9920387
    Abstract: A strain of marine oil degrading bacteria, compounds obtained by fermentation and their uses are published. The name is Alcanivorax dieselolei T6-6, with preservation Number: CGMCC NO: 9033. It belongs to ?-proteobacteria, oceanospirillales, alkane degrading bacteria branch, alcanivorax category and diesel alcanivorax species. The said bacteria can be used to degrade and remove petroleum hydrocarbon, control environmental pollution, produce surfactants, reduce surface tension of water, and for other purposes; a compound can be isolated from secondary metabolites after fermentation, one of which is dieselolei T6-6, 2-amino-6-(N-2-carbonyl-4-tridecyl-cyclobutane) hexanoic acid, and it is a kind of lysine ester. The compound has emulsifying activity on different organics, antibacterial effects against Gram-positive bacteria and fungus, and a better cytotoxic activity.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: March 20, 2018
    Assignee: THIRD INSTITUTE OF OCEANOGRAPHY, STATE OCEANIC ADMINISTRATION
    Inventors: Zongze Shao, Xiaoman Shi, Wanpeng Wang
  • Patent number: 9097693
    Abstract: The invention provides a method for simple, rapid and inexpensive analysis of drugs such as nicotine and other drugs which are accumulated in biological samples of addictive drugger of tobacco, stimulant drug and the like. The method comprises the steps of introducing the biological sample into an injection needle, inserting the needle into an injector of a chromatograph and injecting a carrier into the needle to conduct chromatography treatment.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: August 4, 2015
    Assignees: SHINWA CHEMICAL INDUSTRIES, LTD., NATIONAL UNIVERSITY CORPORATION TOYOHASHI UNIVERSITY OF TECHNOLOGY, NIPPON MEDICAL SCHOOL FOUNDATION
    Inventors: Hiroo Wada, Kiyokatsu Jinno, Yoshihiro Saito, Youkichi Ohno, Makiko Hayashida
  • Publication number: 20150132375
    Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 14, 2015
    Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
  • Publication number: 20150128685
    Abstract: The invention relates to a sampler for providing a sample for high-performance liquid chromatography, in which a volume of liquid to be taken up into a cylinder can be aspirated by means of a first drive and can be compressed to a high pressure level by means of a second drive independent of the first drive or can be decompressed from this level in a controlled manner.
    Type: Application
    Filed: November 5, 2014
    Publication date: May 14, 2015
    Inventors: Adolf SATZINGER, Hermann HOCHGRAEBER, Thomas Armin Alexander EICHHORN
  • Publication number: 20150121996
    Abstract: Automated sample injection apparatus, multiport valves, and chromatography systems containing an automated sample injection apparatus and/or a multiport valve are disclosed. Methods of making and using automated sample injection apparatus and multiport valves within chromatography systems are also disclosed.
    Type: Application
    Filed: January 9, 2015
    Publication date: May 7, 2015
    Applicant: Alltech Associates, Inc.
    Inventors: Raaidah Saari-Nordhaus, Washington Mendoza, Josef Bystron, Neil Picha, Bruce Black
  • Publication number: 20150107334
    Abstract: A method and system for continuous measurement chromatograph involves stochastically modulating a system variable. The sample can be introduced into a chromatography column. The sample introduction can be modulated stochastically. The sample output from the column can be detected and processed with the stochastic input to provide a sample analysis.
    Type: Application
    Filed: October 23, 2014
    Publication date: April 23, 2015
    Inventors: Ian W. Hunter, Eli T. Paster
  • Patent number: 9003868
    Abstract: Disclosed herein is a sample introducing apparatus which is designed such that the analytical flow path runs from the needle to the separation column without the flow path switching means placed at the downstream side of the needle. This design reduces dead volume, which in turn reduces the diffusion of the sample injected into the analytical flow path. Moreover, the absence of the flow path switching means at the downstream side of the needle to inject a sample into the analytical flow path eliminates connection of the pipe with the flow path switching means. This prevents the sample from remaining in the connecting part, thereby reducing sample carry-over and improving the accuracy of analysis.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: April 14, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yumiko Ono, Kimihiko Ishii, Eri Yamashita
  • Publication number: 20150089997
    Abstract: The subject technology is directed to a CO2-based system and method for rapid determination of the levels and/or the presence or absence of polycyclic aromatic hydrocarbons (PAHs).
    Type: Application
    Filed: October 1, 2014
    Publication date: April 2, 2015
    Inventors: Tarang NEMA, Melvin GAY, Mark RITCHIE
  • Publication number: 20150059441
    Abstract: The present invention relates to the use of a microporous organogel for the capture of fluids by adsorption and/or for the controlled release of fluids after solubilization. The fluids are, in particular, air or water pollutants or volatile substances. The invention also relates to the use of a microporous organogel in a process for analyzing the captured fluids. The invention also relates to any fluid sensor by moulding of a microporous organa gel.
    Type: Application
    Filed: April 2, 2013
    Publication date: March 5, 2015
    Inventors: Emile Perez, Sophie Franceschi-Messant, Isabelle Rico-Lattes, Jean-Christophe Garrigues
  • Publication number: 20150059451
    Abstract: A fluid supply system (150) configured for supplying fluids, the fluid supply system (150) comprising a fluid packet supply unit (180) configured for controlling supply of a sequence (250) of fluid packets (222 to 230), the fluid packets (222 to 230) comprising a packet of first fluid (223) and a packet of second fluid (225), wherein the first fluid and the second fluid are media being prone to a phase separation upon direct interaction between the packet of first fluid (223) and the packet of second fluid (225), and a phase separation inhibiting unit (190) configured for inhibiting phase separation by inserting an intermediate fluid packet (224) between the packet of first fluid (223) and the packet of second fluid (225) to 230 to 230
    Type: Application
    Filed: April 25, 2012
    Publication date: March 5, 2015
    Inventors: Klaus Witt, Konstantin Choikhet
  • Patent number: 8969093
    Abstract: Constant calibration methods and apparatuses for analytical devices that are located in remote positions in order to allow for reliable and automated measurements of various contaminants within water or other liquid samples. The proposed calibration systems allow for certain methods to measure total amounts of certain trihalomethane and haloacetic acid contaminants, at least, in drinking water samples from such remote locations, through the utilization of a standard addition introduction of known concentrations of such contaminant compounds within target samples, followed by separation through a capillary membrane sampling device and measurement of such different contaminants via flow injection analysis (FIA). In such a manner, the on-line, remote system provides the necessary reliability for a water utility or like entity on which to base any further needed water treatment activities without having to perform such measurements in a distinct lab setting.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 3, 2015
    Assignee: University of Memphis Research Foundation
    Inventors: Gary Lynn Emmert, Paul S. Simone, Jr.
  • Patent number: 8960231
    Abstract: A multi-mode injection valve includes a stator having an outer stator face and an inner stator face; a plurality of fluid ports in the outer stator face; a plurality of fluid orifices in the inner stator face, the fluid orifices disposed in fluid communication with the fluid ports, respectively; a rotor having a rotor surface engaging the inner stator face of the stator; a plurality of rotor grooves in the rotor surface of the rotor, each of the rotor grooves adapted for fluid communication with a pair of the fluid orifices depending upon a rotational or angular position of the rotor with respect to the stator; and an actuator unit engaging the rotor, the actuator unit adapted to rotate the rotor relative to the stator.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: February 24, 2015
    Inventors: Neil Robert Picha, Bruce D. Black
  • Patent number: 8955375
    Abstract: A device for sampling fluid from an earth formation is disclosed. The device includes: an inlet port disposable in fluid communication with the fluid in a borehole; an injector including an injection chamber in fluid communication with the inlet port, the injector configured to receive a portion of the fluid and direct the fluid toward an analysis unit for analyzing constituent materials in the fluid; and a high pressure valve configured to admit the portion of the fluid at a borehole pressure and release the portion of the fluid into the injector, the portion having a volume that is less than or equal to about one microliter. A system and method for analyzing constituents of fluid in a borehole in an earth formation is also disclosed.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: February 17, 2015
    Assignee: Baker Hughes Incorporated
    Inventors: Rocco DiFoggio, Paul Allan Bergren
  • Publication number: 20150027207
    Abstract: Methods and systems for analyzing ratios of analytes within a flowing sample are provided. The flowing sample can be processed in real-time to determine a time interval over which a predetermined amount of a group of analytes passes by a fixed point in a flow cell. The predetermined amount can be routed to a sample container for future processing. The sample can comprise diluted blood and the analytes can comprise a component of hemoglobin, such as A1c, and the total amount of hemoglobin, of which the predetermined amount is metered.
    Type: Application
    Filed: June 9, 2014
    Publication date: January 29, 2015
    Inventors: Robert K. Likuski, Anthony F. Prestigiacomo, Tong Le, Kurt D. Kramer, Donald J. Bartling
  • Publication number: 20150027206
    Abstract: An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC with refractive index (RI) detection; the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol.
    Type: Application
    Filed: February 26, 2013
    Publication date: January 29, 2015
    Inventor: Xiaoyun Lu
  • Publication number: 20150027203
    Abstract: Methods and apparatus for controlling interdetector band broadening during the analysis of a sample injected into a chromatography system. A column flow is diluted with a dilution flow after the sample exits the chromatography system, and the diluted sample is analyzed by one or a combination of analysis instruments such as a light scattering detector, refractive index detector, an ultraviolet absorption detector.
    Type: Application
    Filed: February 7, 2013
    Publication date: January 29, 2015
    Applicant: Wyatt Technology Corporation
    Inventor: Steven P. Trainoff
  • Patent number: 8933396
    Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: January 13, 2015
    Assignee: Thermo Fisher Scientific GmbH
    Inventors: Joel Louette, John Charles Rogers, Scott M. Peterman, Bruno Domon, Elodie Duriez
  • Patent number: 8932234
    Abstract: Devices, systems, and methods for the collection of biological samples. In at least one exemplary embodiment, a device comprises a collection medium having top and bottom surfaces and a predetermined size and shape, the top surface comprising a position marker and at least one binding site operable to bind a biological sample, a protective facing substantially impermeable to the biological sample, the protective facing coupled to the top surface of the collection medium and having a size and shape substantially similar to the predetermined size and shape of the collection medium. The protective facing being sized and shaped to define a first void positioned to allow for the transfer of the biological sample through the protective facing and onto the at least one binding site of the collection medium, and a second void positioned to expose the position marker for alignment of the collection medium.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: January 13, 2015
    Assignee: Bioanalytical Systems, Inc.
    Inventors: Scott R. Peters, James M. Hampsch
  • Patent number: 8931356
    Abstract: An apparatus for chemical separations includes a first substantially rigid microfluidic substrate defining a first fluidic port; a second substantially rigid microfluidic substrate defining a second fluidic port; and a coupler disposed between the first and second substrates, the coupler defining a fluidic path in fluidic alignment with the ports of the first and second substrates. The coupler includes a material that is deformable relative to a material of the first substrate and a material of the second substrate. The substrates are clamped together to compress the coupler between the substrates and form a fluid-tight seal.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: January 13, 2015
    Assignee: Waters Technologies Corporation
    Inventors: Joseph D. Michienzi, James P. Murphy, Dennis DellaRovere
  • Patent number: 8925375
    Abstract: A multiple loop sample introduction system comprises a valve assembly including a sample collection valve and a sample introduction valve. First and second sample loops are in fluid communication with the sample collection valve and the sample introduction valve to receive aliquots of liquid samples to be introduced into a nebulizer. The valve assembly is operable to port a first aliquot into the first sample loop, while porting a second aliquot received in the second sample loop for introduction into the nebulizer.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: January 6, 2015
    Assignee: Elemental Scientific, Inc.
    Inventor: Daniel R. Wiederin
  • Patent number: 8920658
    Abstract: Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis. The liquid eluent is pumped through a heated nebulizer to create a high-speed jet of solute containing liquid and solvent vapor. This jet is directed circumferentially inside a hot cylindrical cavity. Centrifugal force causes the larger liquid droplets to travel along the outer diameter of the cavity. The cavity surface is heated to cause the droplets to film boil. Film boiling reduces droplet contact with the cavity surface thereby retaining the solute in the droplets. The solute temperature is limited by controlling the pressure into which the solvent evaporates from the droplets.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: December 30, 2014
    Assignee: Spectra Analysis Instruments, Inc.
    Inventors: William W. Carson, Sidney Bourne
  • Publication number: 20140373606
    Abstract: A micromachined flow cell (100), comprising a substrate (102), and a freestanding tube (104) delimiting a fluidic conduit (800) therein and being integrally formed from material of the substrate (102).
    Type: Application
    Filed: February 3, 2012
    Publication date: December 25, 2014
    Inventors: Karsten Kraiczek, John Mannion, Kevin P. Killeen
  • Publication number: 20140377878
    Abstract: The present invention provides a rack for holding sample vials comprising: (i) a solid base; (ii) an upwardly extending wall around the perimeter of said base; (iii) a plurality of means for supporting a plurality of vials, each means for supporting one vial; and (iv) a means for draining liquid from said rack.
    Type: Application
    Filed: December 14, 2012
    Publication date: December 25, 2014
    Inventors: Ross Oliver Beecroft, Victoria Louise Goff, Sarah Jane Karim, Nicholas Brian Milne
  • Publication number: 20140373605
    Abstract: A liquid sampling system includes a liquid sampling valve for transferring a liquid sample from a primary stream to a secondary stream. The liquid sampling valve includes a rotor having a movable shuttle that is in selective fluid communication with the primary stream or the secondary stream. The rotor shuttle passes through a discharge station prior to completion of the valve cycle to discharge contaminants prior to re-exposure to the primary stream.
    Type: Application
    Filed: July 17, 2013
    Publication date: December 25, 2014
    Applicant: IDEX Health & Science LLC
    Inventors: Jon Nichols, Michael Keller, Audrey Schrock, Carl Sims, Carl Servin
  • Patent number: 8906692
    Abstract: Disclosed are an apparatus and method for separation analysis of mannose-6-phosphate (M6P) by post-column fluorescence detection method. The apparatus is based on chromatography, and includes a column with a solid phase having affinity for phosphate, a flow path for the eluate, a heater installed on the flow path for M6P and a basic amino acid to react by heating the eluate in the flow path, and a fluorescence detector installed downstream of the heater for continuously irradiating the eluate with excitation light and measuring the intensity of the emission, and may include in the flow path a supply channel for addition of a basic amino acid between the column and the heater. The method is characterized in that it uses the apparatus and a second mobile phase consisting of a second buffer containing phosphate of predetermined concentration and adjusted to a predetermined pH.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: December 9, 2014
    Inventor: Tetsuo Yokoyama
  • Patent number: 8900877
    Abstract: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: December 2, 2014
    Assignee: Luminex Corporation
    Inventors: Steve Jia Chang Yu, Jesus Ching, Phillip You Fai Lee, David Hsiang Hu
  • Patent number: 8899101
    Abstract: A sampler (10), in particular for use in testing the dissolution behavior of pharmaceutical products, wherein the sampler (10) comprises: a vial holder (20) for accommodating a plurality of vials (22a, 22b); a sampling needle assembly (30) with a plurality of sampling needles, wherein the sampling needle assembly (30) and the vial holder (20) may be moved relative to one another in such a way that the sampling needles of the sampling needle assembly (30) may be inserted into the vials of the vial holder (20); and a pump unit (40) with a plurality of diaphragm pumps (42a, 42b) which are designed to convey a fluid via the sampling needle assembly to the vials in the vial holder (20) and to withdraw a fluid therefrom.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: December 2, 2014
    Assignee: Riggtek GmbH
    Inventor: Hansjürgen Riggenmann
  • Publication number: 20140345371
    Abstract: A sample injector for liquid chromatography includes an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.
    Type: Application
    Filed: August 7, 2014
    Publication date: November 27, 2014
    Inventor: Hermann Hochgraeber
  • Publication number: 20140345370
    Abstract: Certain embodiments described herein are directed to systems and methods that can be used to analyze species in a fluid stream. In some configurations, a sorbent tube effective to directly sample aromatics and/or polyaromatics in a fluid stream is described.
    Type: Application
    Filed: March 13, 2014
    Publication date: November 27, 2014
    Applicant: PERKINELMER HEALTH SCIENCES, INC.
    Inventor: Lee Marotta
  • Publication number: 20140338431
    Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.
    Type: Application
    Filed: August 7, 2014
    Publication date: November 20, 2014
    Inventor: Hermann Hochgraeber
  • Publication number: 20140326055
    Abstract: A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes. The high performance liquid chromatography method of the present invention is suitable for the separation of diastereomers of the same metal complexes. Also provided is a chiral high performance liquid chromatography method to separate enantiomers of metal complexes. Superoxide dismutase mimetic compounds are also provided.
    Type: Application
    Filed: July 14, 2014
    Publication date: November 6, 2014
    Inventors: Urszula J. SLOMCZYNSKA, Bobby N. TRAWICK, Dennis P. RILEY, Arati NAIK
  • Publication number: 20140311228
    Abstract: An analysis method is achieved in which pressure variation resulting from sample injection or passage switching by an autosampler does not exert an influence on the control of a liquid transfer pump. The liquid chromatograph analysis method comprises the steps of: transferring two or more types of eluents while changing a mixing ratio between the eluents; adjusting an amount of the transferred liquid within a predetermined time in a passage for the eluent transferred; injecting a sample in the passage; supplying to a separation column the eluent into which the sample is injected; separating a target component in the sample; and detecting the target component thus separated. In this method, control is exercised so as to synchronize a liquid transfer cycle of the eluent with the sample injecting operation and to implement the sample injecting operation at a timing rather than the pressure obtaining time.
    Type: Application
    Filed: April 14, 2014
    Publication date: October 23, 2014
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Toyoaki TANOUE, Masato FUKUDA, Daisuke AKIEDA
  • Patent number: 8850875
    Abstract: The dispersibility of soot in a lubricant formulation containing a dispersant is evaluated by (a) preparing a dispersion of carbon black in the lubricant formulation; (b) depositing a sample of the dispersed carbon black from step (a) onto a planar chromatography medium; (c) subjecting the sample of (b) to chromatographic conditions and (d) evaluating the extent of migration of the carbon black by comparing the density of darkening due to carbon black at pre-defined locations along the chromatography medium. The liquid mobile chromatography phase comprises a mixture of a liquid non-aromatic hydrocarbon portion having viscosity and boiling point less than that of an oil of lubricating viscosity; and an oil component comprising an oil of lubricating viscosity and the dispersant or dispersants that are also contained within the lubricant formulation.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: October 7, 2014
    Assignee: The Lubrizol Corporation
    Inventors: Mitchell Gentile, Matthew D. Gieselman, Matthew Henley
  • Publication number: 20140245818
    Abstract: This analysis method includes: subjecting a sample solution of a dye-containing sample in an organic solvent to normal-phase liquid chromatography to separate the sample solution and detect separated components. The normal-phase liquid chromatography involves (B1) using a separation column filled with a column packing material which is prepared by modifying a base material with a polar modifying group, and (B2) using as an eluent a polar organic solvent containing an acid.
    Type: Application
    Filed: December 28, 2012
    Publication date: September 4, 2014
    Applicant: SHIMADZU CORPORATION
    Inventor: Daisuke Nakayama
  • Publication number: 20140230528
    Abstract: A mixing device for use in a chromatography system, the device includes an exterior housing having a first end and a second end and a hydraulic flow connector at the first end of the exterior housing. A cartridge including a chamber is enclosed within the exterior housing. The chamber has at least one wall defining an interior volume having a shape, wherein the shape of the interior volume creates a turbulent flow condition to mix at least two fluids and provide flow through the cartridge during operation of the chromatography system. The chamber also retains the sample, thereby ensuring that the sample is focused in the chamber such that a more narrow bolus of sample enters the chromatography column.
    Type: Application
    Filed: June 15, 2012
    Publication date: August 21, 2014
    Applicant: WATERS TECHNOLOGIES CORPORATION
    Inventors: Ziqiang Wang, Chuping Luo, Harbaksh Sidhu
  • Patent number: 8806922
    Abstract: A sample injector for liquid chromatography includes an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: August 19, 2014
    Assignee: Dionex Softron GmbH
    Inventor: Hermann Hochgraeber
  • Publication number: 20140224001
    Abstract: Method for verification of age-depth relationships of rocks in sedimentary basins by reconstructing the subsistence rate of samples, in which, by determining the precipitation depth and precipitation temperature of a carbonate precipitation, wherein by determining the precipitation depth and the precipitation temperature of the carbonate precipitation in the geological-history-determining sedimentary rocks, from which a sample is taken, a set point is fixed.
    Type: Application
    Filed: August 30, 2012
    Publication date: August 14, 2014
    Applicant: GEOMAR HELMHOLTZ-ZENTRUM FUER OZEANFORSCHUNG KIEL
    Inventors: Anton Eisenhauer, Dietrich Horn
  • Patent number: 8800352
    Abstract: An method for optimizing operation of an autosampler coupled to a liquid chromatography (LC) system comprises: reading, from electronic memory storage, a pre-injection time corresponding to the time required for the autosampler to perform operations preparatory to injecting a sample; calculating an autosampler delay time from the pre-injection time and from a sample analysis time; performing the autosampler operations preparatory to injecting the sample after delaying said autosampler operations for the autosampler delay time; measuring a time value for the preceding performing of autosampler operations; replacing the pre-injection time value stored on the electronic memory storage with the measured time value for the preceding performing of autosampler operations if the measured value is greater than the pre-injection time value stored on the electronic memory storage; and injecting the sample from the autosampler into the LC system after receipt of a signal from the LC system by the autosampler.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: August 12, 2014
    Assignee: Thermo Finnigan LLC
    Inventor: Aaron N. Marks
  • Patent number: 8794052
    Abstract: In injecting a sample sucked into a sample loop in an autosampler from an injection needle into an analytical flow path via an injection port by a mobile phase, a sending flow rate of the mobile phase is reduced from a certain flow rate determined in an analysis condition to reduce pressure applied on a joint section between the needle and the injection port to thereby reduce the sample remaining in the injection port.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: August 5, 2014
    Assignee: Shimadzu Corporation
    Inventor: Yoshiaki Maeda
  • Publication number: 20140208836
    Abstract: An apparatus for use in a chromatography system includes a microfluidic substrate having a fluidic channel configured as an analytical chromatographic column and a fluidic port on one side of the microfluidic substrate. The fluidic port opens at a head end of the analytical chromatographic column. A dried blood spot (DBS) collection device holds one or more dried biological samples. The DBS collection device is directly coupled to the microfluidic substrate whereby one of the biological samples is placed into fluidic communication with the fluidic channel of the microfluidic substrate and an extraction of that biological sample flows toward the head end of the analytical chromatographic column. A diluent source fluidically coupled to the fluidic port supplies a solvent to the head end of the analytical column to dilute the extracted biological sample before the biological sample flows into the analytical chromatographic column.
    Type: Application
    Filed: August 22, 2012
    Publication date: July 31, 2014
    Applicant: WATERS TECHNOLOGIES CORPORATION
    Inventors: James P. Murphy, Michael J. Tomany, Joseph D. Michienzi, Paul Rainville, Robert S. Plumb, Geoff C. Gerhardt, Moon Chul Jung
  • Patent number: 8776581
    Abstract: A blood collection module includes a blood collection container that is coupled with a blood alcohol concentration detection device including an alcohol detection sensor having a detection probe that inhales an alcohol gas, and on one surface of which an inserting portion that is inserted by a detection probe of a blood alcohol concentration detection device is formed and on an outer surface of which blood inlet holes through which blood flows in are formed; and an absorption member that is provided in the blood collection container, to thus absorb examinee's blood that is introduced through the blood inlet holes, in which an alcohol gas generated from the blood absorbed by the absorption member is introduced into the alcohol detection sensor through the detection probe.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: July 15, 2014
    Assignee: Elechem Co., Ltd.
    Inventors: Kwang Hee Park, Ik Hyun Park
  • Publication number: 20140190243
    Abstract: A fluorescence spectrophotometer according to the present invention includes: a light source 1; a sample cell 3; an excitation-side light-dispersing system 2 for dispersing a light from the light source 1 and for casting a desired wavelength of light into the sample cell 3; an emission-side light-dispersing system 4 for dispersing a light emitted from the sample cell 3, the emission-side light-dispersing system 4 being located off an optical path of a transmitted light exiting from the sample cell 3 after being cast from the excitation-side light-dispersing system 2 into the sample cell 3; and a photodetector 5 capable of detecting, among the light from the emission-side light-dispersing system 4, an emission light having the same wavelength as the light cast from the excitation-side light-dispersing system 2 into the sample cell 3.
    Type: Application
    Filed: September 30, 2011
    Publication date: July 10, 2014
    Inventor: Masahide Gunji