Abstract: The present invention relates to a deaerator 2 including: a liquid flow space; reduced-pressure spaces 25A, 25B, and 25C; gas permeable films 21A, 21B, and 21C that separate these spaces; and a pump for discharging gas from within the reduced-pressure spaces 25A, 25B, and 25C to the outside, and to a liquid chromatograph equipped with the deaerator 2. The deaerator 2 further includes gas partial pressure variation suppression means 23A, 23B, 23C, 25Ab, 25Bb, 25Cb, 29A, 29B, and 29C for suppressing variations in partial pressures of a specific gas in the reduced-pressure spaces 25A, 25B, and 25C.
Type:
Application
Filed:
February 8, 2007
Publication date:
November 18, 2010
Applicant:
ARKRAY, INC.
Inventors:
Koji Sugiyama, Akira Sezaki, Takanori Kamada, Yoshikiyo Hongo
Abstract: The present invention provides methods and compositions for detecting mutations in a DNAH11 gene of a subject to diagnose primary ciliary dyskinesia (PCD) in the subject and/or to identify a subject as having an increased risk of having PCD and/or to identify a carrier of a PCD mutation.
Type:
Application
Filed:
May 14, 2010
Publication date:
November 18, 2010
Inventors:
Maimoona Banoo Abdul Hamid Zariwala, Michael R. Knowles
Abstract: A method of determining degree of aging of an incompletely cured polymer resin material collecting IR spectra on a series of standards with carefully controlled aging time and data collected at appropriate time intervals with the standard LC method for determining cure condition of the material, using said spectra and LC data to make a multivariate calibration model and using said model to predict the cure condition of uncured samples of interest.
Type:
Application
Filed:
September 22, 2008
Publication date:
November 4, 2010
Inventors:
Paul H. Shelley, Gregory J. Werner, Joe Baratto
Abstract: The flow rate of a solvent is reduced as a separation column and the separation performance is improved even under high-pressure conditions. There is provided a separation column including a monolith rod into which a sample and a mobile phase flow, the separation column comprising: a coating material coated on the outer circumference of a monolith rod; a support member into which the monolith rod coated with the coating material is inserted, and a rod fixing material fitted into or filled a gap between the coating material and the support member; wherein the upper end face of the rod fixing material is sealed, the upper end face being the inflow-side end when the separation column is assembled.
Abstract: The present invention relates to a solid phase extraction body, methods for its manufacture, uses of such extraction body and analytical methods involving such extraction body.
Type:
Application
Filed:
March 24, 2010
Publication date:
September 30, 2010
Applicant:
SYMRISE GmbH & Co., KG
Inventors:
Stefan Brennecke, Andreas Degenhardt, Berthold Weber, Birgit Kohlenberg, Gerhard Krammer
Abstract: The present invention relates to a method for diagnosing a predisposition for diabetes comprising determining at least one metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing said at least one metabolite to a reference, whereby a predisposition for diabetes is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing a predisposition for diabetes.
Type:
Application
Filed:
March 21, 2007
Publication date:
September 23, 2010
Applicant:
Metanomics GmbH
Inventors:
Bianca Bethan, Kristina Busch, Jan Wiemer, Martijn Gipmans, Edgar Leibold, Jochen Spranger, Thomas Bobbert, Andreas Friedrich Hermann Pfeiffer
Abstract: The present invention relates to a novel process for the preparation of pharmaceutically pure olanzapine. The invention is also related to impurities obtained during the preparation of pharmaceutically pure olanzapine and methods for the detection of the impurities.
Abstract: The present invention provides quantitation of seven classes of compounds (saturates, 1-4+ ring aromatics, sulfides, and polars) present in petroleum streams boiling from 550-1050° F. Operating the present invention in the preparative mode will allow us to load and collect multi-milligram amounts of material. In the present invention, all seven fractions are produced in a single run, whereas the most commonly used preparative liquid chromatographic separations requires two or more large scale separations to generate similar fractions. The present invention uses 100 times less solvent. The present invention protocol provides a quicker and cheaper alternative to most commonly used preparative liquid chromatographic separations and is flexible enough to target many refining and chemicals problems.
Abstract: Disclosed is a system or matrix approach for determining compatibility of a pharmaceutically active substance, such as small molecule drug candidate, therapeutic proteins, peptides, vaccines or RNAi, with materials used in the research and development of pharmaceuticals, including plastics, polymers, resins, rubbers, elastomers, glass and steel.
Type:
Application
Filed:
December 17, 2009
Publication date:
August 26, 2010
Inventors:
Brian K. Meyer, Leonardo R. Allain, David Geer, Rajiv Mahajan, David R. Walker, Marc J. Kirchmeier
Abstract: A method for recognizing rejection after a kidney transplantation (NTx), comprising the step of determining the presence or absence of at least one polypeptide marker in a sample, wherein said polypeptide marker is selected from markers 1 to 242 (frequency markers), or determining the amplitude of at least one polypeptide marker selected from markers 243 to 767 (amplitude markers), which are characterized by the values for the molecular masses and migration times (CE time).
Abstract: The present invention relates to a Rehmannia glutinasa Libosch. extract for reducing blood glucose and lipid levels and treating hematologic diseases such as leukemia, and methods for preparing the same. The extract is prepared by subjecting fresh Rehmannia glutinasa Libosch. to flux extraction, concentrating the resultant extract, dissolving the concentrated extract with water, loading the obtained solution on a column packed with macroporous adsorption resins, eluting the column with ethanol, concentrating and drying the eluate. The extract can be made into clinically acceptable forms of dosage by pharmaceutically conventional measures, including capsule, tablet, pill, granule, dropping pill and so on. The extract is stable and has catalpol content up to 90-98%. The preparing method is simple to operate and applicable to industrial-scale production.
Abstract: A method and system of screening or selecting a mobile phase eluent for a chromatography column is provided. A sample for chromatographic analysis or purification is combined with a solvent and passed through a membrane. A pressure measurement is taken of the sample/solvent combination in the system prior to the membrane. The pressure measurement may be compared to a second pressure and an appropriate solvent may be selected based on the relationship between the first measured pressure and the second pressure.
Type:
Grant
Filed:
June 15, 2007
Date of Patent:
August 3, 2010
Assignee:
Cohesive Technologies, Inc.
Inventors:
Hubert M Quinn, Joseph J. Takarewski, Jr., Elizabeth Williams
Abstract: A composition comprising Chinese herbal medicines Ramulus cinnamoni and Poria cocos is provided, wherein the composition is defined by a fingerprint profile obtained from an improved chromatographic method. Various uses of such compositions are also provided.
Type:
Application
Filed:
October 17, 2007
Publication date:
July 22, 2010
Inventors:
Wei Xiao, Xiang Ling Dai, Ya Ling, Zhen Zhong Wang, Yu An Bi, Zheng Kuan Wang
Abstract: A specimen pretreating device which includes a micro scale or nano scale high-performance liquid chromatograph having a capillary column (2), a probe (1) integrally formed at the tip of the capillary column (2), and an additive feeding flow passage (16). The probe (1) is formed in a multi-tube structure in which a plurality of tubes are disposed on the same axis. The innermost tube is located at the tip of the capillary column (2), and one of the outer tubes is used as an additive supply tube converging an additive solution to an eluent solvent eluted from the capillary column (2) to form liquid drops including the eluent solvent and an additive, and the liquid drops are released from the tip of the probe (1). The specimen is not diffused since a detector is not present in the flow passage.
Abstract: Embodiments of the invention provide to apparatuses and media used in drug elution studies and methods for making and using them. One embodiment of the invention is a drug elution method that can be used for in-vitro studies of a matrix impregnated with a compound such as a drug blended polymer matrix. Such methods and materials can be used for example to assess and control the manufacturing process variability of drug eluting implantable devices such as cardiac leads.
Type:
Application
Filed:
December 30, 2008
Publication date:
July 1, 2010
Applicant:
Medtronic MiniMed, Inc.
Inventors:
Sarnath Chattaraj, Elango Minnoor, Eugene Levin, Poonam S. Gulati
Abstract: The present invention relates to a method, a computer tool and a system for detecting peptide peaks in measurement signals (11) generated by HPLC-MS instruments. The method comprises the steps of: providing an intensity column vector (SIC) representative of the elution values at a specific mass value (m/z) of the measurement signal (11); cam.
Type:
Application
Filed:
May 30, 2008
Publication date:
June 24, 2010
Applicant:
Politecnico di Milano
Inventors:
Salvatore Cappadona, Linda Pattini, Sergio Cerutti, Peter James, Fredrik Levander
Abstract: A process for diagnosing vascular diseases (VD), comprising the step of determining the presence or absence of at least one polypeptide marker in a sample, wherein said polypeptide marker is selected from markers 1 to 526, which are characterized by values for the molecular masses and migration times (CE times).
Abstract: A composition having clevidipine as an active ingredient is described. The composition includes clevidipine as an active ingredient and an amount of the impurity H168/79 that is no greater than about 1.5%, or where the ratio between clevidipine and H168/79 is equal or above 60 to 1.
Type:
Application
Filed:
July 29, 2009
Publication date:
May 6, 2010
Inventors:
Rajeshwar Motheram, Gopal Krishna, Min Ding, Keith Flood, Kornepati Ramakrishna
Abstract: Methods of quantifying a N2-carboxyethyl-2?-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of disorders, including diabetes and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels occurs using liquid chromatography electrospray ionization tandem mass spectrometry.
Type:
Application
Filed:
August 10, 2009
Publication date:
April 29, 2010
Inventors:
Samuel Rahbar, Timothy W. Synold, John Termini
Abstract: A method and apparatus for chromatography of a polyolefin polymer by flowing a solution of the polyolefin polymer through liquid flowing through a graphitic carbon liquid chromatography stationary phase. The method can be used to determine the monomer to comonomer ratio of a polyolefin copolymer such as a copolymer of ethylene and 1-octene or a copolymer of propylene and ethylene.
Type:
Application
Filed:
October 2, 2009
Publication date:
April 15, 2010
Inventors:
Freddy A. Van Damme, John W. Lyons, William L. Winniford, Alexander Willem deGroot, Matthew D. Miller
Abstract: The invention provides methods for analyzing heparins, low-molecular-weight heparins, ultralow-molecular-weight heparins, and oligosaccharides by high performance liquid chromatography a stationary phase dynamically coated with a quaternary ammonium salt. The methods of the invention may be used to analyze samples without pre-treatment or to analyze samples that have been partially or exhaustively depolymerised and, optionally, reduced. Specific saccharides can be detected.
Abstract: A High Performance Liquid Chromatography (HPLC) system including a pressure reducer assembly for reducing pressurized streams to ambient pressure. The pressure reducer assembly includes first and second flow restrictors, each coupled to a common chamber that acts as a surge suppressor that mitigates pressure spikes in the discharge lines. The flow restrictors may comprise tubes having a high length-to-diameter ratio. The pressure losses through the flow restrictors, in combination with transition losses as the flow stream enters and exits the chamber, are sufficient to reduce a discharge stream from a specified inlet pressure to substantially ambient pressure, thus eliminating the need for pressurized waste containers.
Abstract: The present invention relates to a method and accompanying device for separating a known or unknown sample into one or more subsamples. By comparing the subsample's measurement profile data to the sample measurement profile data, the performance of the separation can be determined. The separation could be chromatography [such as high-performance liquid chromatography (HPLC), gas chromatography (GC), or the like], electrophoresis [such as capillary electrophoresis (CE) or the like], or another separation technique. The measurement profile data could be ultraviolet/visible (UV/Vis) spectra, mass spectra (MS), or another measurement technique.
Abstract: This invention provides a semiconductor nanoparticle aggregate comprising three or more types of semiconductor nanoparticles, which are different from each other in diameter, have a narrow particle size distribution, and are different from each other in maximum luminous wavelength of an emission spectrum in a wavelength region of 380 nm to 650 nm, a process for producing the semiconductor nanoparticle aggregate, and a biological substance labeling agent utilizing the semiconductor nanoparticle aggregate. The semiconductor nanoparticle aggregate comprises three or more types of semiconductor nanoparticles which have an identical chemical composition, are different from each other in particle diameter and fall within a particle diameter range of 1.8 to 4 nm and are different from each other in maximum luminous wavelength of an emission spectrum in a wavelength range of 380 to 650 nm.
Abstract: A method of providing a conduit (5, 7, 49, 51 93, 129, 131, 151, 231, 233, 259) adapted for conducting a medium, with a functional element. The functional element is adapted for at least one of: coupling, connecting, sealing, fixing, adjusting, aligning, receiving, protecting, and positioning the conduit. A part, comprising a plastic material, is plastified and molded within a forming tool for shaping the form of the functional element and for attaching the functional element to the conduit.
Abstract: The present invention relates to dispersions of nanostructured carbon in organic solvents containing alkyl amide compounds and/or diamide compounds. The invention also relates to methods of dispersing nanostructured carbon in organic solvents and methods of mobilizing nanostructured carbon. Also disclosed are methods of determining the purity of nanostructured carbon.
Type:
Application
Filed:
May 7, 2009
Publication date:
December 31, 2009
Applicant:
ROCHESTER INSTITUTE OF TECHNOLOGY
Inventors:
Brian J. LANDI, Ryne P. RAFFAELLE, Herbert J. RUF, Christopher M. EVANS
Abstract: Nonlinear retention time variations in chromatography-mass spectrometry data sets are adjusted by time-alignment methods, enabling automated comparison of spectra for differential phenotyping and other applications.
Abstract: The present invention provides apparatus and methods for detection of an analyte in liquid chromatography with increased detection sensitivity and signal resolution.
Abstract: A composition of matter wherein the composition comprises a siliceous substrate having silanols on the surface and a polymer selected from the group consisting essentially of a water soluble polymer, a water soluble copolymer, an alcohol soluble polymer, an alcohol soluble copolymer, and combinations of such polymers, wherein the polymer is chemically bonded to the siliceous substrate by a silane linking material having the general formula O3/2SiQY that is derived from an alkoxy-functional silane having the general formula (RO)3SiQX and processes for preparing the crosslinked polymer that is chemically bonded to the surface of the siliceous substrate.
Type:
Application
Filed:
May 5, 2008
Publication date:
November 5, 2009
Inventors:
Warde T. Collins, David E. Graham, Douglas H. Adamson, Robert M. Mininni
Abstract: A device (100) for detecting a condition in a fluid system (14) and initiating a response based on the condition. The device consists of a sensor (12) that responds to a first and second condition of the fluid (13) in the system and a control means (10) that receives the responses and generates command signals in based on the received response. In a liquid chromatography system, the device is used to determine the volume of components of the fluid system. In addition, the device allow leaks to be detected and permits the fluid in the system to be transported at a optimum speed. The device is well implemented utilizing to a light emitter and light receptor that are sensitive to the fluid in either a gaseous or liquid state.
Type:
Grant
Filed:
March 2, 2005
Date of Patent:
October 6, 2009
Assignee:
Waters Technologies Corporation
Inventors:
James E. Usowicz, Peyton C. Beals, Russell Keene, Richard Kent, Miguel Soares, John Heden
Abstract: The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.
Abstract: Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment.
Type:
Application
Filed:
March 12, 2009
Publication date:
September 24, 2009
Applicants:
MDS Analytical Technologies, a business unit of MDS Inc., doing buiness through its Sciex division, Applera Corporation
Abstract: Chiral selectors having ?-unsubstituted ?-amino acid derivatives of the structure: a stationary phase for separating substance mixtures containing the chiral selector, and processes for separating mixtures of chiral substances, including enantiomers, and especially enantiomers of substances selected from ?-amino acids and derivatives thereof, ?-amino acids and ?-hydroxy acids are provided.
Type:
Application
Filed:
March 10, 2009
Publication date:
September 17, 2009
Applicant:
EVONIK DEGUSSA GmbH
Inventors:
Franz-Rudolf Kunz, Peter Richter, Stefan Merget, Roland Singer, Thomas Mueller
Abstract: A HPLC based analytical method for identification and quantification of related substances of imipenem, cilastatin and their combination is disclosed.
Abstract: An HPLC column holding apparatus used to mount an HPLC column in one of a plurality of positions is disclosed herein. The apparatus comprises a clip-device interface that secures the apparatus to a platform and a clip-column interface that secures the HPLC column to the apparatus.
Type:
Grant
Filed:
October 12, 2004
Date of Patent:
August 18, 2009
Assignee:
Waters Technologies Corporation
Inventors:
David P. Prentice, Roger Gilman, Brett G. Cook
Abstract: A method of recovering and recycling solvents, comprising, during printing or coating of solvent-recoverable and recyclable printing ink composition comprising solvents, a step of recovering the solvents vaporized in a solvent recovery apparatus, a step of separating the solvents obtained into one or more single solvents and/or one or more azeotropic compositions of two or more solvents by multi-stage distillation, and a step of recycling them as a printing ink raw material and/or dilution solvent raw material.
Abstract: Provided are rosuvastatin degradation products and their use as a reference standard (including reference marker) for analysis of rosuvastatin.
Abstract: Systems, methods, and computer-readable media for determining composition of chemical constituents in a complex mixture are disclosed. According to one aspect, a method for determining composition of chemical constituents in a complex mixture includes generating, using a separation tool and a mass spectrometer, separation and mass spectrometry data of a sample, wherein the separation data includes peak information and wherein the mass spectrometry data includes primary and secondary mass spectrometry data. The analysis results, including the generated separation and mass spectrometry data, are collected and stored. A chemical constituent of the sample is determined by comparing the analysis results to a library of information indicating characteristics of chemical entities, where the comparison is based on the separation and mass spectrometry information.
Type:
Application
Filed:
December 3, 2008
Publication date:
July 16, 2009
Inventors:
K. Eric Milgram, Thomas Barrett, Anne M. Evans
Abstract: A temperature programmed low thermal mass fast liquid chromatography system capable of high throughput and low power consumption includes a straight or curved short reloadable low-mass tubular heater with a capillary column extending inside. If the capillary column is long enough, it is coiled to form a coiled capillary LC column (the length of which does not exceed 0.2 m-1.0 m) packed in a singular module package with a heating wire and a temperature sensing wire extending along and in proximity to the LC capillary column. A tubular heater, e.g. a steel tubing, incorporates the LC capillary column, along with the heating wire and the temperatures sensor and is coiled to form a miniature power saving LC module which may be attached outside a chromatography oven. Capillary lengths extend inside the oven between the inlet and outlet of the LC column module and mobile phase source and detector, respectively.
Type:
Application
Filed:
January 7, 2008
Publication date:
July 9, 2009
Inventors:
Matthias Pursch, Patric Eckerle, Jim Luong, Hernan Cortes, Ronda Gras, Kevin Hool, Robert Mustacich
Abstract: A stationary medium is employed both to separate chemicals from a sample solution and also to generate surface-enhanced Raman scattering, so that spectral analysis of the separated analyte chemical can be performed. Applied driving force causes the sample to flow into the stationary medium and to distribute therethrough, thereby causing rapid separation of the analyte chemical, and surface-enhanced Raman scattered radiation is quickly detected, at a plurality of locations along a flow path defined by the stationary medium, for ultimate analysis.
Type:
Application
Filed:
January 29, 2009
Publication date:
July 2, 2009
Inventors:
Stuart Farquharson, Paul Maksymiuk, Chetan S. Shende
Abstract: Embodiments of the invention provide to apparatuses and media used in drug elution studies and methods for making and using them. One embodiment of the invention is a drug elution method that can be used for in-vitro studies of a matrix impregnated with a compound such as a drug blended polymer matrix. Such methods and materials can be used for example to assess and control the manufacturing process variability of drug eluting implantable devices such as cardiac leads.
Type:
Application
Filed:
December 28, 2007
Publication date:
July 2, 2009
Inventors:
Sarnath Chattaraj, Poonam S. Gulati, Eugene Levin, Elango S. Minnoor
Abstract: Advanced remote self-contained chromatographic systems and techniques for analyzing a mixture comprising components having a wide range of boiling points. The chromatographic systems and techniques can utilize components and techniques that allow staged, simultaneous, and/or sequential vaporization of an analyte to facilitate rapid analysis. The chromatographic systems and techniques can also utilize components and techniques that focus eluents from a first separation stage prior to reduce characterization time in subsequent stages.
Type:
Application
Filed:
October 9, 2008
Publication date:
June 25, 2009
Applicant:
SCHLUMBERGER TECHNOLOGY CORPORATION
Inventors:
Neil William Bostrom, Robert Leonard Kleinberg, Kristofer Gunnar Paso, Bhavani Raghuraman, Gordon R. Lambertus
Abstract: Provided is a differential refractive index detector having a light receiving element, a zero glass, a zero glass driving unit and a storing portion, and is capable of performing purging operation thoroughly based on a unified standard. The light receiving element receives a measuring light passing through cells (S, R) to generate a slit image. The zero glass makes the slit image parallelly move on the light receiving element. The zero glass driving unit makes the zero glass rotate. The storing portion stores a rotating angle of the zero glass when the same solution fills up the two cells (S, R). When a purging operation for replacing a reference solution in the flow cell is performed, the stored rotating angle is taken as a standard value for being compared with a current rotating angle of the zero glass. If the two angles are the same, the purging operation is finished.
Abstract: There is provided a user interface which enables all users to input a purpose of use of a chromatography data system, recognize a series of operation flow of the analysis of chromatograph data according to the input purpose, improve an operability and prevent an operation error regardless of the user's knowledge on analyzing the chromatograph data or the user's proficiency in the chromatography data system. In a chromatograph data processing, the present invention relates to recognizing chromatograph data analyzing means on a picture and displaying the chromatograph data analyzing means on the picture in accordance with purpose of use. According to the present invention, the chromatography data system can be easily operated regardless of the knowledge on the analysis of chromatograph data or proficiency in the chromatography data system.
Abstract: It is an object of the present invention to provide a method capable of easily identifying a coloring material composition. The method performs a chromatography step of loading a subject sample containing the coloring material composition to a chromatography apparatus that holds a separating base material containing a cellulosic material and a metallic oxide material, and of performing a chromatography using a mobile phase of a liquid in the analysis of the coloring material composition. According to such a chromatography apparatus, coloring materials contained in the coloring material composition can be favorably and easily separated.
Abstract: An apparatus for liquid chromatography comprises a liquid chromatography separation column on a substrate, wherein the separation column is coupled to a heater on the substrate. A chip-based temperature controlled liquid chromatography device comprises a substrate, a thermal isolation zone, and a separation column thermally isolated from the substrate by the thermal isolation zone. An apparatus for chip-based liquid chromatography comprising a cooling device is provided. A temperature gradient liquid chromatography system comprises a chip-based temperature controlled liquid chromatography device, a fluidic coupling, and an electrical interface. Methods of making and methods of using of chip-based temperature gradient liquid chromatography devices are also provided.
Type:
Grant
Filed:
February 17, 2005
Date of Patent:
May 12, 2009
Assignee:
California Institute of Technology
Inventors:
Yu-Chong Tai, Jun Xie, Chi-yuan Shih, Qing He
Abstract: An apparatus and method for electrochemically modifying the retention of a species on a chromatography material is disclosed. The apparatus comprises a housing having an effluent flow channel adapted to permit fluid flow therethrough. The effluent flow channel comprises chromatography material. The apparatus further comprises first and second electrodes positioned such that at least a portion of the chromatography material is disposed between the first and second electrodes, and fluid flow through the apparatus is between, and in contact with, the first and second electrodes.
Type:
Grant
Filed:
May 18, 2005
Date of Patent:
May 12, 2009
Assignee:
Dionex Corporation
Inventors:
James M. Anderson, Jr., Raaidah Saari-Nordhaus, Carl W. Sims, Yuri E. Gerner