Abstract: The present invention provides a one-piece pipette/dropper assembly that includes a pipette portion, a threaded cap portion, and bulb portion. The cap potion has a top wall including a top and bottom surface and the bulb portion has a first end integrally formed with the top wall of the cap on the top surface. The pipette portion has a first end integrally formed with the top wall of the cap on the bottom surface thereof. The bulb potion communicates with the pipette potion through the first end of the pipette portion and the pipette portion has an opening in a second end for receiving and discharging a fluid.

Abstract: A fluid dispensing system and method includes a pump to aspirate and expel sample fluid, a fluid dispensing tip, and a metering station. The fluid dispensing tip includes a working fluid and an air gap where the air gap separates the working fluid from the sample fluid. The metering station receives a drop of sample fluid that is at least twice as large as the predetermined volume to ultimately be dispensed. The fluid dispensing tip then withdraws the predetermined volume of fluid from the sample fluid. Precise volumes are ascertained by prior knowledge of the geometry of the fluid dispensing tip and by using an imaging device to monitor an interface of either the sample fluid or working fluid with the air gap within the fluid dispensing tip. The system and method are capable of accurately dispensing very small volumes of sample fluid on the order of 10 picoliters. In addition, the system and method do not require large volumes of sample fluid to prime a pump mechanism.

Abstract: A fluid dispensing system and method includes a pump to aspirate and expel sample fluid, a fluid dispensing tip, and a metering station. The fluid dispensing tip includes a working fluid and an air gap where the air gap separates the working fluid from the sample fluid. The metering station receives a drop of sample fluid that is at least twice as large as the predetermined volume to ultimately be dispensed. The fluid dispensing tip then withdraws the predetermined volume of fluid from the sample fluid. Precise volumes are ascertained by prior knowledge of the geometry of the fluid dispensing tip and by using an imaging device to monitor an interface of either the sample fluid or working fluid with the air gap within the fluid dispensing tip. The system and method are capable of accurately dispensing very small volumes of sample fluid on the order of 10 picoliters. In addition, the system and method do not require large volumes of sample fluid to prime a pump mechanism.

Abstract: After attaching a disposable pipette tip to an end of pipetting probe, which is held by a movable holder, humidity in the pipette tip is increased before a pipetting operation of a sample or a reagent. The pipette tip is transferred to a high humid chamber provided with a warmer, and high humid air is introduced into the pipette tip. Subsequently, the pipetting operation of the sample or the reagent is performed. Accordingly, an exact amount of the sample or the reagent can be supplied to a reaction vessel.

Abstract: A hand-held pipettor comprising a piston received in one end of a cylinder, a pipettor tip removably secured to an opposite end of said cylinder, means for reciprocating said piston through a selected stroke to aspirate fluid into and to expel the thus aspirated fluid from said pipettor tip, mutually spaced stop members operatively associated with said manually driven means for defining the range of said stroke and motor driven means for varying the spacing between said stop members to thereby vary the volume of fluid being aspirated into and expelled from said pipettor tip.

Abstract: A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.

Abstract: A microarrayer for spotting solution onto slides in an automated microarray dispensing device. Elements of the present invention include: at least one dispense head for spotting the slides, at least one light source capable of illuminating the slides, at least one camera operating in conjunction with the at least one light source. The at least one camera is capable of acquiring and transmitting slide image data to a computer. The computer is programmed to receive the slide image data and analyze it. The computer will then generate post analysis data based on the analysis of the slide image data. The post analysis data is available for improving the spotting of the solution onto the slides. In a preferred embodiment, the slide image data includes information relating to slide alignment, information relating to spot quality, and slide identification information.

Abstract: The invention concerns a liquid transfer device for an analysis apparatus with a liquid transfer cannula (5) and a capacitive liquid level detector to detect the immersion of the liquid transfer cannula (5) in an analysis liquid contained in a vessel. To reliably check if the liquid transfer cannula (5) is submerged in the analysis liquid or immersed for example in foam it is proposed additionally that resistance is measured by a measurement section (16) in the liquid transfer cannula (5).

Abstract: The present invention relates to a ceramic tip and a random access print head for the transfer of microfluidic quantities of fluid. The print head can randomly collect and deposit fluid samples to transfer the samples from a source plate to a target. The print head can also be programmed to create a direct map of the fluid samples from the source plate on the target or to create any desired pattern or print on the target. The tip and print head can be used for a wide variety of applications such as DNA microarraying and compound reformatting. In one preferred embodiment, the tip is used as a capillary or “gravity” pin to draw or collect source fluid and “spot” or deposit the fluid onto the target via physical contact (touch-off). In another preferred embodiment, the tip is used in conjunction with an aspirate-dispense system to actively aspirate source fluid and deposit the fluid via a contact or non-contact approach.

Abstract: A device and related method for dispensing liquid. The device includes a housing configured to contain a plurality of liquid dispensing members containing a liquid and configured to contain a receiving member in a receiving position to receive the liquid from the plurality of liquid dispensing members. The housing defines a first pressure chamber and a second pressure chamber. The first pressure chamber is capable of being sealed relative to the second pressure chamber. The device also includes a differential pressure generator operably connected to one of the first and second pressure chambers. The generator is capable of generating a pressure differential between the first and second pressure chambers to cause the plurality of liquid dispensing members to dispense liquid onto the receiving member.

Abstract: A pipette for the handling of a syringe. The pipette has jaw chucks which are adjustably arranged with respect to the plunger receptacle, being pivotably mounted on a plunger-gripping device. The syringe is insertable with opened jaw chucks with the plunger head only partially contacting the jaw chucks. The jaw chucks are laterally engageable on the plunger head upon insertion of the syringe. The engaging movement of the jaw chucks on the plunger head is regulated according to the invention so that the engaging movement has a substantially tangential component with respect to the surface of the plunger head. As a result, a desired and form-locking connection to the plunger head of the syringe results that requires a small amount of force.

Abstract: Apparatus and methods for aspirating and dispensing reagents are provided. Aspirating of reagents is accomplished by a probe, a vial insert and reagent vial according to the present invention wherein a seal is formed between the probe and the vial insert when the probe engages the vial insert. Dispensing of reagents is accomplished by a probe and a probe dispense and wash station according to the present invention wherein a seal is formed between the probe and the vial insert when the probe engages the probe dispense and wash station.

Abstract: The present invention relates to a disposable, preselected-volume, capillary pipette device for picking up and transferring a selected volume of a liquid sample such as blood.

Abstract: The device serves for the transfer of microobjects, in particular of biological objects, from a current substrate (9) to a target substrate. In this case, use is made of a displaceable pipette system which is connected to a pressure generating device for aspirating in and flushing out the biological objects. The pipette system is disposed in a micromanipulator (3) and consists mainly of a substantially vertically disposed microcapillary (1) having a clear width of 1 &mgr;m to 50 &mgr;m.

Abstract: A liquid proportioning method using a chamber for a gas and a reception volume connectable thereto for a liquid with an aperture to the environment, wherein a desired volume is predetermined for the liquid to be taken up by the reception volume, a chamber negative pressure is determined which has to exist in the chamber to cause the desired liquid volume to be taken up in the reception volume after the aperture is dipped into the liquid and the chamber is connected to the reception volume, the chamber negative pressure is produced in the chamber, the reception volume dips its aperture into the liquid, and the chamber is connected to the reception volume and the desired volume of the liquid is taken up in the reception volume.

Abstract: An electronic metering device with a drive comprising an electric drive motor, at least one displacement device comprising a piston fixed to an axle drivable by the drive, for metering the fluid, and an electronic control for the drive motor, with a transducer which converts a feed voltage delivered by an electrical voltage source into a supply voltage for the drive, the supply voltage being matched in size to the respective load of the drive.

Abstract: In one embodiment, a particle-retrieval device in accordance with the present teachings includes a receiver tube, vacuum-flow providing means and particle-disengaging means. The receiver tube is in fluid communication with the vacuum-flow providing means such that when flow is introduced into the vacuum-flow providing means, a suction or vacuum flow is developed at an end of the receiver tube. The suction causes a particle to adhere to the end of the receiver. A particle is disengaged by discontinuing the suction and, advantageously, by wetting the engaged particle.

Abstract: The invention relates to a device in which at least two liquid or semi-liquid reagents can be stored separately. When used, the inventive device enables precise, chronologically defined, sequential reagent discharge in a reaction chamber by means of a linear movement without any prior mixing of said reagents.

Abstract: The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.

Abstract: In a pipette device comprising at least one pipette channel and at least one pump means, which cooperates with the pipette channel for suction and dispensed delivery of liquid, the pump means consists of two electrically driven micropumps each having one suction-side and one pressure-side connection, one of which is connected to the pipette channel via its suction side and the other via its pressure side. The pipette device thereby acts as an air cushion pipette and is preferably provided with current via solar cells.

Abstract: A method and apparatus therefor for depositing a flattened droplet on a partially absorbent surface comprising the steps of providing a narrow bore transfer tube having a proximal end and a distal end and containing a microvolume of liquid, the proximal end connected to a pneumatic system adapted for issuing an outgoing flow of displacement gas into the tube and drawing an incoming flow of displacement gas therefrom; and issuing an outgoing flow of displacement gas for slowly discharging substantially the entire microvolume of liquid as a droplet on the surface and controllably blowing one or more bubbles into the droplet towards the end of its discharge for flattening the droplet on the surface.

Abstract: The present invention provides a method, and an apparatus, for forming a prescribed concentration of a substance in a mixture with a fluid, from a comparatively dilute mixture. The mixture is most preferably a solution of a solute in a solvent. The following summary and description generally discuss the invention in terms of a particularly preferred solution and a preferred use for that solution; however, in its broadest embodiments, the invention encompasses both the use for other solutions, and the use for a suspension of a solid substance in a fluid to form a mixture (which can also be referred to as a slurry). The invention provides for significant economic, safety and quality benefits over conventional evaporative systems.

Abstract: In a pipette device comprising at least one pipette channel and at least one pump means, which cooperates with the pipette channel for suction and dispensed delivery of liquid, the pump means consists of two electrically driven micropumps each having one suction-side and one pressure-side connection, one of which is connected to the pipette channel via its suction side and the other via its pressure side. The pipette device thereby acts as an air cushion pipette and is preferably provided with current via solar cells.

Abstract: It has been hard to suck the high viscosity sample by using the syringe and to stop the suction of the sample. A sample sucking-discharging device in the invention comprises an injector provided with a cylinder and a piston installed in the cylinder so as to move up and down; a main body for holding the cylinder of the injector; a gear or a pair of gears held in the main body so as to rotate on an axis right-angled to the moving direction of the piston; a first rack, of which one end is connected with the piston, for moving with meshing to the gear or the pair of gears; and, a second rack held in the main body so as to move in the direction opposite to or crossing with the moving direction of the first rack.

Abstract: An exchangeable oscillating pipette needle for an automatic analyzer for examining biological body fluids is provided, in which the analyzer has a holder provided with a tension spring, and with which the oscillating arm, carrying the pipette needle and resting on a knife-edge bearing, is fixed in a stationary position and is releasably connected.

Abstract: A delivery apparatus has, in a housing (13), a cannula (8) whose rear end is connected to a diluter (17) via a connecting tube (16). A piezoelectric actuator (10) increases in length under the action of a control signal and acts on a membrane (6) pierced by the cannula tip (9) and belonging to an interchangeable polypropylene pipette tip mounted on the delivery apparatus and adhering to the housing (13) by means of a collar (7) resting against said housing, and causing said membrane to sag, with the result that a drop of a sample liquid which was previously sucked in by means of the diluter (17) and whose accurately adjustable volume is between 1 nl and 1 &mgr;l is ejected from an outlet orifice (4). After a pipetting process the pipette tip is ejected by means of a slide (15). If the level of the sample liquid in the pipette tip always remains below the cannula tip (9), virtually no carry-over occurs.

Abstract: A volume adjustable manual pipette having a hand-holdable housing supporting (i) an electronic digital display and associated position sensing and control circuitry, (ii) a plunger unit and (iii) a quick set volume adjustment mechanism for simultaneously controlling the volume setting of the pipette and the electronic display, the quick set volume adjustment mechanism comprising a pipette volume setting member for limiting upward movement of the plunger unit within the housing to define the volume setting for the pipette and the volume setting member being supported for axial movement on the plunger unit and releasably secured relative to the housing by a pipette user operable locking mechanism. When released from the housing, the volume setting member is axially moveable on and with the plunger unit to quickly set the volume for the pipette.

Abstract: The sample dilution module includes an oil filled aspiration probe and mixing chamber that communicate with each other while the mixing chamber is maintained at an angle of approximately 5 to 45 degrees below a horizontal axis. The aspiration probe is maintained in a vertical orientation. A micro-bubble is aspirated between separate aspirations of test sample and diluent to prevent contact between the sample and diluent in the aspiration probe. The test sample and diluent are then drawn from the vertically oriented aspiration probe into the mixing chamber. After the sample and diluent are in the mixing chamber the micro-bubble of air can migrate away from the test sample and diluent to enable the test sample and diluent to contact each other. Mixing of the test sample and diluent is accomplished by moving the test sample and diluent back and forth in the mixing chamber without physical agitation of the mixing chamber and without any mixing element in the mixing chamber.

Abstract: A sperm analysis system has a sperm sample carrier (20) and “reader” module. The sperm sample carrier includes: 1) a shank (24) defining a chamber (26) with an opening for ingress and egress of a sperm sample; a manually operated pump (28) for aspirating a sample of sperm into the chamber (26), and a plurality of distinct photon paths (34) intersecting and passing through the chamber (26). The module includes: a processor responsive to an actuation signal from an operator, a photon source, e.g.

Abstract: The invention concerns a device for cleaning pipette needles or stirrers, the device comprising a trough which holds cleaning fluid and whose lower region has a fluid duct for filling and/or emptying purposes and whose upper region has at least one feed pipe which leads into at least one nozzle directed into the trough interior. Advantageously, the device has a cylindrical trough and an insert with nozzles which is screwed into the trough. The invention further concerns a method of cleaning pipette needles or stirrers, the material to be washed being introduced into the trough interior and sprayed with a washing fluid. The device can also be used to flush the interior of a pipette needle.

Abstract: A method and apparatus is provided for depositing a flattened droplet on a surface. The method includes the steps of providing a tube with a distal end that contains a microvolume of liquid, issuing an outgoing flow of displacement gas for slowly discharging substantially the entire microvolume of liquid as a droplet on the surface, and controllably blowing one or more bubbles into the droplet for flattening the droplet on the surface.

Abstract: An automatic analysis apparatus with a liquid level detection function includes a pipetting device for pipetting a liquid sample from a sample cup to a reaction container by using a pipetting probe that serves as a first capacitor electrode. A sample cup holding means serves as a second capacitor electrode having a ground potential. The conductor material is arranged along a direction in which the pipetting probe moves down for pipetting and is separate from the pipetting device. The conductor material has the same ground potential as that of the sample cup holding means and also serves as a second electrode whereby at any one time either of the sample cup holding means and the conductive material serves as a second capacitor electrode in combination with the first capacitor electrode.

Abstract: Apparatus and a method for mixing a liquid within a disposable aspirating probe tip so that most of the liquid is forced to move past a transition zone between two different inside diameters to cause rotational mixing. The apparatus and method can be used to provide agglutination of blood, which in turn can be used for blood typing. The probe tip can comprise a single integral piece, or two separate portions.

Abstract: Apparatus and a method for mixing a liquid within a disposable aspirating probe tip so that most of the liquid is forced to move past a transition zone between two different inside diameters to cause rotational mixing. The apparatus and method can be used to provide agglutination of blood, which in turn can be used for blood typing. The probe tip can comprise a single integral piece, or two separate portions.

Abstract: A method and device for storing and dispensing specified subsets from a collection of tens, hundreds or thousands of different reagents to specified locations within microtitre trays or microarray substrates or the like. The reagents of interest are stored in racks of syringe-like dispensers. These dispensers and/or substrates and/or actuators are controllably moved by automated means to a dispensing position where a single action, vibration and weighing system transfers a controlled quantity to a specified location in a microtitre tray or the like. Deficits of the prior art, such as evaporation, cross-contamination, oxidation, waste of reagents and lab-ware, and human operator non-reliability are overcome.

Abstract: The present invention is directed to the use of deposited thin films for chemical or biological analysis. The invention further relates to the use of these thin films in separation adherence and detection of chemical of biological samples. Applications of these thin films include desorption-ionization mass spectroscopy, electrical contacts for organic thin films and molecules, optical coupling of light energy for analysis, biological materials manipulation, chromatographic separation, head space adsorbance media, media for atomic molecular adsorbance or attachment, and substrates for cell attachment.

Abstract: An embodiment of the apparatus comprises a hollow tubular body (a) of a cross-section size larger than the diameter of any single particle but smaller than twice the diameter to accommodate passage of a single particle at a time through the hollow tubular body and (b) of a length to accommodate a predetermined number of particles. The apparatus includes an obstruction within the body that permits passage of fluid but prevents passage of a particle. The apparatus also includes a force applicator at one end of the tubular body to apply a force to draw a flow of fluid and particles into an end of the element to fill the hollow tubular body with particles along a length of the body up to the obstruction and to maintain the force so as to retain the particles within the body while transporting the retained particles to a location.

Abstract: An automatic measuring apparatus comprising an annular conveyor for conveying specimen receptacles each having a top opening and reaction receptacles each having a top opening in an intermixed manner, conveyance means for imparting a drive to the conveyor, dispensing means for acquiring a certain amount of specimen from the specimen receptacles and for discharging it into the reaction receptacles, and transfer means for transferring the dispensing means in both the horizontal and vertical directions, wherein a horizontally extending track of the dispensing means defined by the transfer means coincides with part of a receptacle conveyance track provided by the conveyance means.

Abstract: In order to surely and correctly detect the liquid level of the sample even if the sample cup (5) is not directly set on the sample disk (105), the cup (5) is mounted on the test tube (6) set on the sample disk (105) and moved to a sample pipetting position. A conductive material served as a liquid level detecting electrode is provided between the sample pipetting probe and said sample disk (105). The sample pipetting probe start to move down, and when tip of the sample pipetting probe contact with the liquid level, and change of an electrostatic capacitance between the conductive material and the sample pipetting probe is detected, the moving down motion of the sample pipetting probe is stopped.

Abstract: Mechanisms are provided for automatically removing tips from a pipette nozzle and/or for detecting the type of tip mounted to the nozzle. For detipping, mechanical energy is stored when the tip is mounted to the nozzle and is released when the tip is to be removed to facilitate removal thereof. A mechanism is preferably provided which limits the force with which the tip is mounted to the nozzle and an overforce mechanism may be provided to facilitate removal of a stuck tip. For detecting tip type, each tip type has a different base configuration which results in a different relative displacement between the nozzle and a surrounding component as a result of the tip contacting both during tip mounting, the difference in relative displacement being detected to identify tip type.

Abstract: A magnetic material attracting/releasing control method makes use of a pipette device sucking a liquid from or discharging a liquid into a container. A magnet body or bodies are provided in a liquid suction line of the pipette device, and any magnetic material contained in liquid sucked into the liquid suction line by magnetic force are deposited on the internal surface of the line. The magnetic material is released and discharged together with liquid from the liquid suction line to a state where the effect of the magnetic force generated by the magnet body is cut off.

Abstract: A one-piece pipette/dropper assembly comprising a pipette portion, a threaded cap portion, and a bulb portion, said cap portion having a top wall including a top surface and a bottom surface, said bulb portion having a first end integrally formed with the top wall of the cap on the upper surface thereof, said pipette portion having a first end integrally formed with the top wall of the cap on the lower surface thereof, said bulb portion communicating with said pipette portion through said first end and an opening in a second end on said pipette for receiving and discharging fluid.

Abstract: A pipette station is described for use in the field of sample analysis. The pipette station increases the rate and ease with which a liquid may be manipulated into and out of sample carriers such as microwell plates. The pipette station includes shafts in the X, Y, and Z direction which possess ball screws which are integrated with motor shafts thus improving accuracy and eliminating the need for a coupling apparatus thereby reducing the space required for the pipette station. The pipette station may be interfaced with an automated laboratory system.

Abstract: A membrane actuated fluid dispensing head apparatus and method for dispensing fluids. The dispenser housing has a top plate, a bottom plate, and a fluid distribution plate disposed between the top and bottom plates. The top plate has fluid inlet means therethrough for admitting pressurized fluid over the distribution plate, the bottom plate having a plurality of elongated hollow pipettes thereon extending away from the top plate and in fluid communication with the fluid distribution plate. A first resilient membrane is disposed between the fluid distribution plate and the bottom plate, the bottom plate having a plurality of spaced cavities thereon having outer peripheries and in fluid communication with the pipettes. A second resilient membrane is disposed between the top plate and the distribution plate having an opening therethrough.

Abstract: A bilaterally symmetrical lightweight hand holdable battery powered microprocessor controlled electronic pipette including an axially elongated hollow housing having a vertically extending longitudinal axis. An upper portion of the housing includes a forward compartment containing a forwardly facing alpha-numeric display, a plurality of columns of forwardly facing control keys and plurality of forwardly facing trigger switches arranged in a vertically spaced pattern such that a user in gripping a lower handle portion of the housing in either his or her right or left hand can easily reach with his thumb the control keys, trigger switches as well as a push button of a pipette tip ejector.

Abstract: The sample dilution module includes an oil filled aspiration probe and mixing chamber that communicate with each other while the mixing chamber is maintained at an angle of approximately 5 to 45 degrees below a horizontal axis. The aspiration probe is maintained in a vertical orientation. A micro-bubble is aspirated between separate aspirations of test sample and diluent to prevent contact between the sample and diluent in the aspiration probe. The test sample and diluent are then drawn from the vertically oriented aspiration probe into the mixing chamber. After the sample and diluent are in the mixing chamber the micro-bubble of air can migrate away from the test sample and diluent to enable the test sample and diluent to contact each other. Mixing of the test sample and diluent is accomplished by moving the test sample and diluent back and forth in the mixing chamber without physical agitation of the mixing chamber and without any mixing element in the mixing chamber.

Abstract: A magnetic material attracting/releasing control method makes use of a pipette device sucking a liquid from or discharging a liquid into a container. A magnet body or bodies are provided in a liquid suction line of the pipette device, and any magnetic material contained in liquid sucked into the liquid suction line by magnetic force are deposited on the internal surface of the line. The magnetic material is released and discharged together with liquid from the liquid suction line to a state where the effect of the magnetic force generated by the magnet body is cut off.

Abstract: A work station for simultaneously performing multiple assays includes a base structure, a receptacle rack assembly received within a receptacle rack well formed in the base structure, a pipette tip rack assembly received within a pipette tip rack well formed in the base structure, a multiple conduit substance transfer device, and substance transfer device positioning structure. The receptacle rack assembly holds a plurality of receptacles in which a plurality of individual assays are performed, and the pipette tip rack assembly holds a plurality of contamination limiting pipette tips. The substance transfer device is capable of simultaneously dispensing substances into two or more receptacles or simultaneously removing substances from two or more receptacles. Alternatively, the substance transfer device is capable of simultaneously dispensing substances into two or more receptacles, and, at about the same time, simultaneously removing substances from two or more receptacles.

Abstract: A pipette for the handling of a syringe. The pipette has jaw chucks which are adjustably arranged with respect to the plunger receptacle, being pivotably mounted on a plunger-gripping device. The syringe is insertable with opened jaw chucks with the plunger head only partially contacting the jaw chucks. The jaw chucks are laterally engageable on the plunger head upon insertion of the syringe. The engaging movement of the jaw chucks on the plunger head is regulated according to the invention so that the engaging movement has a substantially tangential component with respect to the surface of the plunger head. As a result, a desired and form-locking connection to the plunger head of the syringe results that requires a small amount of force.

Abstract: A dispensing bulb having a squeezable body portion and integral squeezable neck portion having a pair of diametrically disposed vent holes. An adaptor is mounted in the neck portion and is provided with a cylindrical portion extending into the bulb neck portion beyond the vent holes and spaced radially inwardly therefrom. A dispensing tube is connected to the adaptor and communicates with the interior of the bulb. The neck portion of the bulb is squeezed to draw liquid into the tube, and the cylindrical portion of the adaptor limits the squeezing of the neck portion to prevent liquid from being drawn through the tube into the body portion of the bulb.