Chromatography Type Apparatus Patents (Class 96/101)
  • Patent number: 9921194
    Abstract: A wavy micro gas chromatography column includes a silicon substrate and a bonded glass cover. A micro channel having a rectangular cross section is etched on the silicon substrate and coated with a stationary phase film. A projection figure of the micro channel on the silicon substrate includes multiple regular wavy curves. Each wavy curve is formed through alternately connecting first upper arcs with first lower arcs. Because the groove has a curving structure, the carrier gas velocity is decreased as the increase of the arc angle, resulting in an improvement of the flow uniformity at the zones between two adjacent bends but also an enlarging nonsymmetric distribution at the bends. Thus, an optimal curving structure can make the overall flow more even, and in turn achieve a better separation performance compared to the straight channel columns. Meanwhile, a wavy channel realizes a longer column length on a given area.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: March 20, 2018
    Assignee: University of Electronic Science and Technology of China
    Inventors: Xiaosong Du, Huan Yuan, Xulan Zhao, Penglin Wu, Yadong Jiang
  • Patent number: 9075068
    Abstract: A porous layer open tubular (PLOT) column includes capillary tubing; one or two particle traps disposed inside one or two end sections of the capillary tubing; and a stationary phase comprising a porous or non-porous material coated inside a main section of the capillary tubing. A method for preparing a porous layer open tubular (PLOT) column includes preparing one or two particle traps inside one or two end sections of a capillary tubing; and preparing a stationary phase comprising a layer of a porous material coated inside a main section of the capillary.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: July 7, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Jan Adriaan Peene, Liying Yu
  • Patent number: 9034186
    Abstract: A chromatography column is prepared with a stationary phase comprising a deuterated poly(ethyleneglycol), or other deuterated polymer. Formation of the stationary phase can be performed using exactly the same methodology as used when forming a stationary phase with the equivalent non-deuterated polymer. The deuterated poly(ethyleneglycol), or other deuterated polymer, preferably has increased thermal stability as compared to non-deuterated poly(ethyleneglycol), or equivalent non-deuterated polymer. This reduces bleeding of the stationary phase during gas chromatography and allows the use of greater operating temperatures.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: May 19, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Franciscus Biermans, Jacobus Duvekot
  • Patent number: 8974580
    Abstract: A collimator fixed to the cold jet nozzle of a modulator of a two-dimensional gas chromatograph to aid in the alignment of the cold jet nozzle and loop modulator tube.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: March 10, 2015
    Assignee: ExxonMobil Research and Engineering Company
    Inventor: Frank C. Wang
  • Patent number: 8968560
    Abstract: Methods and related apparatuses and mixtures are described for chromatographic analysis. The described system includes a pressurized source of a mobile phase and a flow path in fluid communication with the pressurized source such that the mobile phase flows through the flow path. The system also includes an injector in fluid communication with the flow path and downstream of the pressurized source, the injector being configured to inject a sample into the flow path. A first column located downstream of the injector, contains a stationary phase, and forms part of the flow path. A first detector is positioned to detect properties of fluid in the flow path at a location downstream of the injector and upstream from the first column. A second detector is positioned to detect properties of fluid in the flow path at a location downstream of the first column.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: March 3, 2015
    Assignee: Schlumberger Technology Corporation
    Inventor: William H. Steinecker
  • Patent number: 8882894
    Abstract: The invention relates to a vaporization injector for a gas chromatograph, said injector comprising a structure (11) mounted in a detachable manner on the gas chromatograph body and including the sample introduction means, the vaporization chamber and pneumatic connections for feeding the carrier gas to the vaporization chamber and to the septum purge means, as well as pneumatic connections for evacuating the splitted sample and carrier gases.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: November 11, 2014
    Assignee: Thermo Fisher Scientific S.p.A.
    Inventors: Stefano Pelagatti, Eric Phillips, Paolo Magni
  • Publication number: 20140290491
    Abstract: A housing of a column unit is tubular-shaped, and includes a first opening and a second opening, and an inner space separated from outside air by an insulating material. An air cooling section including a cooling device is arranged on a side of the first opening of the housing. At the time of cooling the inside of the inner space of the housing, air is caused, by a fan, to flow through the air cooling section and from the side of the first opening to a side of the second opening. A column section including a separation column and a heater is arranged inside the housing. A gap through which air flows from the first opening to the second opening is formed between the column section and an inner wall of the inner space of the housing.
    Type: Application
    Filed: March 26, 2014
    Publication date: October 2, 2014
    Applicant: SHIMADZU CORPORATION
    Inventors: Masaki Kanai, Takahiro Nishimoto, Masanori Nishino, Satoshi Matsuoka
  • Patent number: 8845794
    Abstract: A non-seizing taper used for purged capillary tubing connections in gas chromatography that stops capillary tubing at a predictable position within the taper during installation and maintains space for gas to flow past the capillary tubing. The disclosed taper is an improved component of commonly used purged devices such as inlet liners and purged unions. The arresting aspect of the taper simplifies the process of capillary tubing installation while ensuring that the tubing will reproducibly be positioned in the taper. One or more features of the taper prevent tubing from seizing within the taper so that the devices can be reused and ensure that there is open space for a portion of gas to flow around and past the tubing. The angle of the taper, the dimensions of the taper, and the nature of the features within the taper can be adjusted to meet specific performance, usability and/or manufacturability requirements.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: September 30, 2014
    Inventor: Matthew Spangler Klee
  • Patent number: 8795410
    Abstract: The problem to be solved by the present invention is to provide a monolith adsorbent which can adsorb a target sample easily in a short time or regardless of whether the amount of the sample is small or large and extract the sample with a small amount of solvent, and easily secure the sample necessary for analysis, and a method and an apparatus for adsorption and retention using the same. The present invention is a monolith adsorbent formed by allowing a monolith structure body to contain an adsorbing material such as activated carbon or graphite, exposing the adsorbing material on the surface of the structure body and further surface-treating the surface of the monolith structure body with a hydrophobic or hydrophilic compound or a resin.
    Type: Grant
    Filed: June 18, 2008
    Date of Patent: August 5, 2014
    Assignee: GL Sciences Incorporated
    Inventors: Atsushi Sato, Hiroyuki Terashima, Yoshiyuki Takei
  • Patent number: 8784543
    Abstract: A non-seizing taper used for purged capillary tubing connections in gas chromatography that stops capillary tubing at a predictable position within the taper during installation and maintains space for gas to flow past the capillary tubing. The disclosed taper is an improved component of commonly used purged devices such as inlet liners and purged unions. The arresting aspect of the taper simplifies the process of capillary tubing installation while ensuring that the tubing will reproducibly be positioned in the taper. One or more features of the taper prevent tubing from seizing within the taper so that the devices can be reused and ensure that there is open space for a portion of gas to flow around and past the tubing. The angle of the taper, the dimensions of the taper, and the nature of the features within the taper can be adjusted to meet specific performance, usability and/or manufacturability requirements.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: July 22, 2014
    Inventor: Matthew Spangler Klee
  • Patent number: 8778059
    Abstract: Methods and related systems are described for improving component separations in chromatography through novel techniques. The improvements in separation is due primarily to the provision of differential acceleration of the components being separated. Various systems and methods for providing differential acceleration are described including: increasing the cross section of the column towards the column outlet, changing the thickness or other composition of stationary phase within the column, and providing a temperature and/or mobile phase velocity gradient along the column.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: July 15, 2014
    Assignee: Schlumberger Technology Corporation
    Inventors: William H. Steinecker, Jagdish Shah, Oleg Zhdaneev, Gordon R. Lambertus, Hua Chen
  • Publication number: 20140165841
    Abstract: A plate-type capillary column has extensibility that enables a capillary to be extended as a whole to improve resolution of a chromatograph by stacking respective plate-type capillary columns. The capillary column is provided with a plate having first and second face plate parts that face each other; a capillary that is formed inside the plate; a first bottom-equipped hole connected to one end part of the capillary and formed to open in the first face plate part; and a second bottom-equipped hole connected to the other end part and formed to open in the second face plate part, wherein as viewed from a direction vertical to the first face plate part or the second face plate part, on a capillary column first virtual circle, passing through the second bottom-equipped hole, one or more through-holes penetrating through the first face plate part and the second face plate part are formed.
    Type: Application
    Filed: August 3, 2012
    Publication date: June 19, 2014
    Applicant: HORIBA STEC, CO., LTD.
    Inventor: Takahiro Otsuka
  • Publication number: 20140165840
    Abstract: There is provided a capillary column comprising a flat cross section and a desired theoretical plate number and having both high resolution and high sample load capacity. The capillary column 1 comprising a stationary phase on an inactivated inner surface, which is used in gas chromatography, comprises a narrow part 3 formed in a central part of a cross section of internal space and a bulge part 4 formed on each of both sides of the narrow part 3.
    Type: Application
    Filed: December 17, 2013
    Publication date: June 19, 2014
    Applicant: Frontier Laboratories, Ltd.
    Inventors: Chuichi Watanabe, Koichi Ito, Atsushi Watanabe
  • Publication number: 20140138351
    Abstract: A method for the production of a separation microcolumn made in silicon wafer (11), for a chromatographic or gas-chromatographic system, is described. According to the method, a micro-trench (14) is first made in the silicon wafer. The micro-trench extends in depth in the silicon wafer (11) and along the entire path of the microcolumn. Then, a perfectly circular micro-channel (20), tangent to the upper surface of the silicon wafer (11), is obtained by an in-depth isotropic etching with reactive ions in the micro-trench (14). The microcolumn is functionalized by applying a stationary phase (SP) to the inner wall and finally, another wafer or a layer (17) of silicon or silicon oxide or polymeric material, that acts as a cap or cover, is applied onto the silicon wafer, thus closing the micro-channel. According to a variation, the functionalization is carried out after the micro-channel closure.
    Type: Application
    Filed: July 11, 2012
    Publication date: May 22, 2014
    Applicant: Pollution S.r.l.
    Inventors: Fulvio Mancarella, Ivan Elmi, Stefano Zampolli, Antonella Poggi, Giancarlo Cardinalli, Maddalena Belluce, Stefano Galli, Mario Galli, Filippo Baravelli
  • Patent number: 8721768
    Abstract: Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: May 13, 2014
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Andrew Tipler
  • Patent number: 8701464
    Abstract: A gas chromatography system comprising a sample introduction device, an oven coupled to the sample introduction device and a detector coupled to the oven is disclosed. In certain examples, the oven may be configured to receive a chromatography column in a space in the oven. In some examples, the oven may be constructed and arranged to provide a substantially constant temperature to the space during an analysis stage of the gas chromatography system.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: April 22, 2014
    Assignee: Perkinelmer Health Sciences, Inc.
    Inventors: Andrew Tipler, James Botelho, Avinash Dalmia, Michael J. Rafa, John Vanderhoef, Paul Schallis, Neal Green, David J. Scott, John McCaffrey, Paul St. Cyr, E. Joel McCorkle, Giuseppe Coppola
  • Patent number: 8695401
    Abstract: The disclosure describes a substrate with a fluid-handling assembly coupled to the substrate, the fluid-handling assembly including a plurality of fluid-handling components removably coupled to the substrate and removably coupled to each other. The plurality of fluid handling components includes a gas chromatograph having a fluid inlet and a fluid outlet, and a detector array having a fluid inlet and a fluid outlet, wherein the fluid inlet of the detector array is fluidly coupled to the fluid outlet of the gas chromatograph. A control circuit is communicatively coupled to at least one of the plurality of fluid-handling components, and a readout circuit communicatively coupled to the detector array and to the control circuit. Other embodiments are disclosed and claimed.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: April 15, 2014
    Assignee: TricornTech Corporation
    Inventors: Li-Peng Wang, Chien-Lin Huang, Tsung-Kuan A. Chou
  • Patent number: 8685240
    Abstract: A capillary column (10) includes a tube structure having inner walls (14) and a sol-gel substrate (16) coated on a portion of inner walls (14) to form a stationary phase coating (18) on inner walls (14). The sol solution used to prepare the sol-gel substrate (16) has at least one baseline stabilizing reagent and at least one surface deactivation reagent resulting in the sol-gel substrate (16) having at least one baseline stabilizing reagent residual and at least one surface deactivating reagent residual. A method of making the sol-gel solution is by mixing suitable sol-gel precursors to form the solution, stabilizing the solution by adding at least one baseline stabilization reagent, deactivating the solution by adding at least one surface deactivation reagent to the solution, and reacting the solution in the presence of at least one catalyst.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: April 1, 2014
    Assignee: University of South Florida
    Inventors: Abdul Malik, Abuzar Kabir, Chetan Shende
  • Publication number: 20140060331
    Abstract: A porous layer open tubular (PLOT) column includes capillary tubing; one or two particle traps disposed inside one or two end sections of the capillary tubing; and a stationary phase comprising a porous or non-porous material coated inside a main section of the capillary tubing. A method for preparing a porous layer open tubular (PLOT) column includes preparing one or two particle traps inside one or two end sections of a capillary tubing; and preparing a stationary phase comprising a layer of a porous material coated inside a main section of the capillary.
    Type: Application
    Filed: August 31, 2012
    Publication date: March 6, 2014
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Jan Adriaan Peene, Liying Yu
  • Publication number: 20140026757
    Abstract: A vial feed device is equipped with a feed arm, which is positioned between a vial tray and an oven and below either of them and having a feeding housing unit and a cooling housing unit, and a vial up-and-down moving mechanism for placing and removing vials in and from vial tray and oven. Feed arm is rotationally driven by a drive motor to move a feeding housing unit, a cooling housing unit and up-and-down moving mechanism toward vial tray or oven. High-temperature vials in oven are housed in cooling housing unit until cooling time T elapses. After cooling time T elapses, cooling housing unit is moved to a lower part of vial tray by feed arm, to be returned to vial tray by up-and-down moving mechanism.
    Type: Application
    Filed: July 26, 2012
    Publication date: January 30, 2014
    Applicant: SHIMADZU CORPORATION
    Inventors: Takashi INOUE, Takeshi MAJI, Hirotaka NAGANUMA, Shinichi MITSUHASHI, Yoshitaka NODA
  • Patent number: 8636957
    Abstract: The present disclosure relates to a spirally wrapped chromatographic structure, a system incorporating such structure and a method of providing such structure. The structure may include an absorber layer having a first surface and a second surface, wherein one or a plurality of channels are defined in the first surface. The structure may also include a support layer having a first surface and a second surface, the first surface of the support layer disposed on the second surface of the absorber layer, wherein the absorber layer and the support layer comprise a spiral configuration such that at least a portion of the first surface of the absorber layer contacts at least a portion of the second surface of the support layer.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: January 28, 2014
    Assignee: Southwest Research Institute
    Inventors: Stephen Thomas Wellinghoff, Kent Edward Coulter
  • Patent number: 8603833
    Abstract: The present invention provides germania-silica-based sol-gel monoliths that form the solid-phase material for extraction, isolation, preconcentration, and separation of analytes. In one embodiment, the germania-silica-based sol-gel monolith can be used to coat surfaces of the inner walls of extraction and chromatographic columns. In a preferred embodiment, the sol-gel germania-silica monolith of the present invention is formed from hydrolysis and polycondensation of precursors comprising tetraethoxygermane, tetramethoxysilane, and polyethylene glycol. Also provided are methods of preparing the germania-silica-based sol-gel monolith of the present invention.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: December 10, 2013
    Assignee: University of South Florida
    Inventors: Abdul Malik, Erica B. Turner, Scott S. Segro
  • Patent number: 8591630
    Abstract: In a fast gas chromatograph (GC) method and device for obtaining fast gas chromatography analysis, a capillary gas chromatography column is inserted into a resistively heated metal tube located mostly outside a standard gas chromatograph oven, which may serve as a heated transfer line to a flexible column that enters the resistively heated metal tube from its injector and exits into its detector. The fast GC device enables less than one minute full range temperature programming and cooling back analysis cycle time. The fast GC according to one embodiment is combined with mass spectrometry with supersonic molecular beams for the provision of fast analysis cycle time together with highly informative mass spectral information for improved sample analysis and identification.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: November 26, 2013
    Inventors: Aviv Amirav, Alexander B. Fialkov
  • Patent number: 8591734
    Abstract: A method comprising liquefying a gas to thereby obtain a liquefied gas; injecting a sample into a mobile phase containing a solvent and a supercritical fluid formed from the liquefied gas; passing this mobile phase through a column so that the mobile phase containing desired substance is divided into the solvent and the gas; and separating the desired substance from the solvent, wherein when the pressure of the gas divided from the mobile phase is higher than the pressure of the gas fed for formation of the liquefied gas from gas supply device, the gas divided from the mobile phase is liquefied. Further, there is provided a vapor liquid separator for use in the method.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: November 26, 2013
    Assignee: Daicel Chemical Industries, Ltd.
    Inventor: Akihiro Matabe
  • Patent number: 8585970
    Abstract: A flow through cartridge for solid phase extraction of an analyte from a liquid has a cartridge body bounding a passage for retaining a sorbent. The passage extends from a first end face to a second end face, opposite the first end face of the cartridge body. The cartridge body is composed of a core of a first material extending around the passage and sealing rings of a second material, extending around an axis of the passage at the first and second end faces. Surface portions of the sealing rings constituting surface portions of the first and second end faces. The first material is stronger and stiffer than the second material.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: November 19, 2013
    Assignee: Spark Holland B.V.
    Inventor: Hermannus Geert Gijlers
  • Patent number: 8529672
    Abstract: Methods and systems for cooling gas chromatography ovens that comprise a housing having a fluid entry and a sleeve positioned within the housing to provide a fluid gap between the inner surface of the housing and the outer surface of the sleeve, where the sleeve is coupled to the fluid entry, and where a cooling fluid from the fluid entry traverses the inner layer of the sleeve and thereafter the outer layer of the sleeve via the fluid gap. In one embodiment, the housing includes at least one adjustable fluid exit, and the fluid gap is in fluid communications with the fluid exit(s). The fluid entry and the sleeve can be concentric, and the sleeve can include a heating element. A fan can be positioned to drive the cooling fluid from the fluid entry.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: September 10, 2013
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Jim Botelho, Stephen Pignataro, Jr., John Mezzoni, John H. Vanderhoef
  • Patent number: 8512457
    Abstract: Methods and related systems are described for improving component separations in chromatography through novel techniques. The improvements in separation is due primarily to the provision of differential acceleration of the components being separated. Various systems and methods for providing differential acceleration are described including: increasing the cross section of the column towards the column outlet, changing the thickness or other composition of stationary phase within the column, and providing a temperature and/or mobile phase velocity gradient along the column.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: August 20, 2013
    Assignee: Schlumberger Technology Corporation
    Inventors: William H. Steinecker, Jagdish Shah, Oleg Zhdaneev, Gordon R. Lambertus, Hua Chen
  • Patent number: 8512456
    Abstract: The invention is directed to an oven for use in gas chromatography. In one embodiment, the oven is comprised of a housing that defines an interior chamber within which a substantial portion of a heating element and a radial fan blade are located. The interior chamber also defines a space within which a separation column is located when the oven is in use. The substantial portion of the heating element is located so as to receive air, when the oven is in operation, that is being moved by the radial fan blade in a direction that is substantially perpendicular to the axis of rotation of the blade. The space within which a separation column is located is also defined so as to receive air, when the oven is in operation, that is being moved by the radial fan blade in a direction that is substantially perpendicular to the axis of rotation of the blade.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: August 20, 2013
    Assignee: Wasson-ECE Instrumentation, Inc.
    Inventors: John G. Wasson, Robert J. Wasson
  • Patent number: 8506801
    Abstract: A device for capillary chromatography comprising at least one first receiving space arranged in a circuit board and of a form such that the first receiving space is suitable for at least partially receiving a coiled part of a capillary separation column. Also a method for manufacturing such a device. Using such a device and method the greatest possible advantage can be gained from both miniaturized and integrated gas chromatographs (minimal dead volumes; integration options; small thermal masses and rapid temperature regulation; low cost price; small dimensions, weight and energy consumption; portable and flexible in use) and from the use of a usual capillary separation column (very good separation; high precision and reproducibility). The capillary separation column can herein be heated uniformly, rapidly and accurately.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: August 13, 2013
    Assignee: Concept to Volume B.V.
    Inventors: Gert-Jan Burger, Anne Freerk De Jager, Harm Jan Van Weerden
  • Patent number: 8506688
    Abstract: A gas chromatographic device comprises an inlet system and a chromatography column. The inlet system includes a liner having pressure reducing means contained therein for reducing pressure between an inlet of the pressure reducing means and an outlet of the pressure reducing means. When the devise is in use, the chromatography column is positioned in the liner of the inlet system downstream from the pressure reducing means, and the chromatography column is under vacuum at its outlet.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: August 13, 2013
    Assignee: Restek Corporation
    Inventors: Jaap De Zeeuw, Jack Cochran, Scott L. Grossman
  • Patent number: 8499615
    Abstract: A gas chromatograph comprising two separating devices disposed one behind the other, and through which a material sample is conducted by a carrier gas. A pressure regulator regulates the pressure of the carrier gas introduced into the first separating device. A controllable switching device is arranged between the two separating devices. The switching device contains a main gas path lying between the two separating devices and two auxiliary gas paths, which are connected to the main gas path through connecting gas paths and are both fed with the carrier gas and contain flow resistors and a controllable valve for setting different pressure conditions. The auxiliary gas paths are supplied with the carrier gas through the same pressure regulator to reduce the design and adjustment effort in setting the pressure conditions, where fixed resistors are used for the flow resistors.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: August 6, 2013
    Assignee: Siemens Aktiegesellschaft
    Inventor: Piotr Strauch
  • Publication number: 20130192463
    Abstract: Embodiments of the present disclosure provide for collection devices, methods of making collection devices, methods of collecting gases and aerosol particles, and the like.
    Type: Application
    Filed: October 17, 2011
    Publication date: August 1, 2013
    Inventors: Chang-Yu Wu, Yu-Mei Hsu, Alex Theodore, Lin Shou, Danielle Lyon Hall
  • Publication number: 20130180405
    Abstract: A multicapillary bundle for use in a gas chromatograph. Each of the capillaries in the bundle is formed using a coating solution containing a stationary phase and a solvent. The capillaries are coated with stationary phase by reducing pressure at a vacuum end of the capillary and creating a moving interface between the coating solution and a film of stationary phase deposited on each of the capillaries. The reducing pressure at the vacuum end of the capillary and the temperature of the capillary are controlled to maintain motion of the moving interface away from the vacuum end of the capillary. Maintained movement of the interface prevents recoating of the stationary phase. A heating wire and capillaries are embedded in a thermally conductive polymer to create a highly responsive method of heating the multicapillary column. An electronic control device controls the feedback temperature of the multicapillary column using the heating wire.
    Type: Application
    Filed: January 13, 2012
    Publication date: July 18, 2013
    Inventors: Ron W. Currie, David Christiansen
  • Patent number: 8414684
    Abstract: A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: April 9, 2013
    Assignee: Dionex Corporation
    Inventors: Yan Liu, Christopher A. Pohl, Michael McAdams, Hamish Small, Zhongqing Lu, Milton Liu, Khosro Moshfegh
  • Patent number: 8409510
    Abstract: In the invention, a collection device includes a flow through micro scale plate arranged to collect analyte. The plate includes holes, and sorbent coating on contact surfaces of the plate. The holes pass analyte fluid flow, for example analyte vapor so that fluid flow for collection may be generally perpendicular to the sorbent plate. Preferred embodiment plates include an integrated heater trace. In preferred embodiments, a high substantially perpendicular flow is used for collection and concentration, and during desorption and delivery a low substantially parallel flow is used. The low flow is selected to meet constraints of a detector system.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: April 2, 2013
    Assignees: The United States of America as represented by the Secretary of the Navy, University of Louisville Research Foundation, Inc.
    Inventors: Robert Andrew McGill, Michael Martin, Mark Crain, Kevin Walsh, Eric Houser, Stanley Vincent Stepnowski, Viet Nguyen
  • Patent number: 8398851
    Abstract: The invention relates to a device and to a method for determining the proportion of fuel in a combustion engine lubricating oil. The device according to the invention comprises a column (12) with at least 22000 theoretical plates and a steady state phase capable of separating the fuel, the oil, the internal standard contained in the oil and the solvent, in which the oil and the internal standard are diluted, and a heating module (120) capable of causing an increase in the temperature of the column (12) at a rate of at least 350° C./min. In the method according to the invention, the column (12) is subjected to determined cycles during which the pressure of the carrier gas and the temperature are varied.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: March 19, 2013
    Assignee: Renault S.A.S.
    Inventors: Laurent Tiquet, Pierrick Rouille
  • Patent number: 8389289
    Abstract: A gas chromatograph (GC) apparatus capable of detecting abnormality, in which a reference retention index is obtained from a result obtained by analyzing a given substance and a retention-index reference substance under adequate analysis conditions using a normal column, and stored in a storage section. Further, under a condition that the apparatus can perform normal analysis, the given substance is subjected to GC analysis to obtain a reference retention time, and the obtained reference retention time is stored in the storage section. A diagnosis processing section is operable to compare each of an actual retention time and an actual retention index with a respective one of the reference retention time and the reference retention index. If a deviation therebetween or abnormality is detected, the diagnosis processing section is operable to estimate a causal factor of the abnormality.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: March 5, 2013
    Assignee: Shimadzu Corporation
    Inventor: Shuichi Kawana
  • Patent number: 8377309
    Abstract: Methods for depositing a stationary phase in a tube for chromatography, in particular, as a variable gradient column are disclosed. The methods include providing a tube having a first end and a second end, the tube containing a fluid composition comprising a stationary phase precursor and a solvent, connecting the first end of the tube to a flow device, removing the solvent from a meniscus of the fluid composition, the solvent exiting the tube at the second end, and operating the flow device while removing the solvent such that the amount of the stationary phase precursor deposited within the tube changes as the meniscus retreats within the tube to deposit a stationary phase having a thickness gradient along the length of the interior of the tube.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: February 19, 2013
    Assignee: Nobull Innovation LLC
    Inventor: William H. Steinecker
  • Patent number: 8357234
    Abstract: An apparatus and method for rapid fractionation of hydrocarbon phases in a sample fluid stream are disclosed. Examples of the disclosed apparatus and method include an assembly of elements in fluid communication with one another including one or more valves and at least one sorbent chamber for removing certain classifications of hydrocarbons and detecting the remaining fractions using a detector. The respective ratios of hydrocarbons are determined by comparison with a non separated fluid stream.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: January 22, 2013
    Assignee: UT-Battelle, LLC
    Inventors: Charles S. Sluder, John M. Storey, Samuel A. Lewis, Sr.
  • Publication number: 20130000485
    Abstract: A flow control system, method and device for performing thermal desorption is provided. In one embodiment, the system includes a first flow path in which gas flows from a first carrier gas inlet, through a first vessel in a first direction at a first flow rate to adsorb analytes on an adsorbent of said first vessel; a second flow path in which gas flows from a second carrier gas inlet, through said first vessel in the first direction at a second flow rate to further adsorb the analytes on the adsorbent of said first vessel; a third flow path in which a carrier gas flows through said first vessel in a second direction to carry desorbed analytes out of said first vessel; and wherein the second flow rate of carrier gas through said first vessel is greater than the first flow rate of carrier gas through said first vessel.
    Type: Application
    Filed: June 29, 2011
    Publication date: January 3, 2013
    Inventors: Andrew Tipler, Greg Johnson, David J. Scott
  • Patent number: 8329038
    Abstract: Methods for depositing a stationary phase in a tube for chromatography. The resulting column may be a variable gradient column or a standard open tubular column with a uniform thickness stationary phase. The methods include providing a tube comprising an electrically conductive interior surface and having a composition within the tube, the composition comprising a stationary phase precursor and at least one of an electrolyte and a reactant precursor, and electrochemically reacting the reactant precursor or the stationary phase precursor to form a stationary phase in the tube.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: December 11, 2012
    Assignee: Nobull Innovation LLC
    Inventor: William H. Steinecker
  • Patent number: 8322189
    Abstract: The present invention is an improvement to two-dimensional comprehensive gas chromatography. The improvement is a one valve switching modulator connecting the two separation columns. The valve includes either a two position eight-port valve or a two position twelve-port valve, and two transfer lines.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: December 4, 2012
    Assignee: ExxonMobil Research and Engineering Company
    Inventor: Frank C. Wang
  • Patent number: 8318010
    Abstract: A chromatography column and method for use in a liquid chromatography process includes a telescoping chromatography and piston tubes, with the piston tube having a porous layer partially obstructing flow therethrough. A chromatography clamp is selectively movable between open and closed positions, and configured to extend substantially 360 degrees about the periphery of the chromatography tube when closed. The chromatography clamp is configured to releasably maintain the chromatography tube and piston tube in fluid communication with one another. In particular embodiments, the chromatography clamp includes a ledge extending at an oblique angle relative to the transverse direction, which is configured to cam the clamp towards the closed position upon application of greater than atmospheric pressure within the chromatography column.
    Type: Grant
    Filed: May 3, 2010
    Date of Patent: November 27, 2012
    Inventor: E. Daniel Yukon
  • Publication number: 20120285325
    Abstract: A gas chromatography system comprising a sample introduction device, an oven coupled to the sample introduction device and a detector coupled to the oven is disclosed. In certain examples, the oven may be configured to receive a chromatography column in a space in the oven. In some examples, the oven may be constructed and arranged to provide a substantially constant temperature to the space during an analysis stage of the gas chromatography system.
    Type: Application
    Filed: December 22, 2011
    Publication date: November 15, 2012
    Applicant: PerkinElmer LAS, Inc.
    Inventors: Andrew Tipler, James Botelho, Avinash Dalmia, Michael J. Rafa, John Vanderhoef, Paul Schallis, Neal Green, David J. Scott, John McCaffrey, Paul St. Cyr, E. Joel McCorkle, Giuseppe Coppola
  • Patent number: 8308854
    Abstract: A system for recycling helium carrier gas comprises: a bladder, the bladder interior fluidically configured so as to receive helium-bearing gas output from at least one of a split vent and a septum purge vent of a gas chromatograph; a compartment containing the bladder; a source of pressurized air or gas operable so as to supply pressurized air or gas into the compartment interior so as to compress the bladder containing the helium-bearing gas; a gas reservoir fluidically coupled to the bladder interior so as to receive the helium bearing gas from the compressed bladder interior; and at least one gas purification module configured so as to receive the helium-bearing gas from the gas reservoir and operable to remove contaminants from the helium-bearing gas, an output of the at least one gas purification module being fluidically coupled to a carrier gas inlet of the gas chromatograph.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: November 13, 2012
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Matt A. Lasater
  • Patent number: 8303694
    Abstract: Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: November 6, 2012
    Assignee: Perkinelmer Health Sciences, Inc.
    Inventor: Andrew Tipler
  • Patent number: 8293111
    Abstract: Methods and apparatuses for chromatography are provided, using, for example, water as a stationary phase and carbon dioxide as the mobile phase.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: October 23, 2012
    Assignee: UTI Limited Partnership
    Inventor: Kevin B. Thurbide
  • Patent number: 8277544
    Abstract: A thermal modulation device for a gas chromatography (GC) system a cold zone, a first hot zone and a second hot zone, which are located outside of a GC oven of the GC system, and a flexible capillary column. The cold zone includes a thermoelectric cooler assembly. The first hot zone is adjacent a first side of the cold zone, and has a corresponding first heat source. The second hot zone is adjacent a second side of the cold zone, and has a corresponding second heat source. The flexible capillary column includes a first segment, configured to move between the first hot zone and the cold zone in accordance with a modulation frequency, and a second segment, configured to move between the cold zone and the second hot zone in accordance with the modulation frequency.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: October 2, 2012
    Assignee: Agilent Technologies, Inc.
    Inventors: Xiaosheng Guan, Qiang Xu
  • Patent number: 8230719
    Abstract: The present invention is directed to a method for multidimensional gas chromatography for separating the analytes of a complex sample. The method comprises the steps of introducing the sample onto a first column whereby the sample is separated into at least two segments, introducing at least one segment into a heartcut device whereby the segments are selectively separated into at least two heartcut fractions, introducing at least one of the fractions onto a second column whereby at least one fraction is further separated into at least two analytes, introducing at least one analyte from the second column to a gas chromatography connector, introducing the analyte from the connector to a third column, and introducing the analyte from the third column into a detector whereby the analyte is analyzed and identified.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: July 31, 2012
    Assignee: MRIGlobal
    Inventor: Chad Fisher
  • Publication number: 20120118156
    Abstract: Methods for depositing a stationary phase in a tube for chromatography, in particular, as a variable gradient column are disclosed. The methods include providing a tube having a first end and a second end, the tube containing a fluid composition comprising a stationary phase precursor and a solvent, connecting the first end of the tube to a flow device, removing the solvent from a meniscus of the fluid composition, the solvent exiting the tube at the second end, and operating the flow device while removing the solvent such that the amount of the stationary phase precursor deposited within the tube changes as the meniscus retreats within the tube to deposit a stationary phase having a thickness gradient along the length of the interior of the tube.
    Type: Application
    Filed: November 16, 2010
    Publication date: May 17, 2012
    Applicant: NOBULL INNOVATION LLC
    Inventor: William H. Steinecker