Abstract: Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilising a plurality of ligands comprising carbohydrate groups. These “nanoparticles” can then be used to study carbohydrate mediated interactions, e.g. with other carbohydrates or proteins, and as therapeutics and diagnostic reagents.

Abstract: Provided is a signal amplifying method in a lateral flow analysis with high sensitivity, in which gold ions and a reductant are added and react to a seed of gold nano particles to amplify a signal, and a lateral flow analysis device using the same.

Abstract: The present invention provides methods and compositions for treating non-small-cell lung cancer (NSCLC) by administering a) a composition comprising nanoparticles that comprise paclitaxel and an albumin and b) a platinum-based agent (e.g., carboplatin). The present application also provides methods of treating prostate cancer by administering to the individual a) an effective amount of a composition comprising nanoparticles comprising docetaxel and an albumin; and b) an effective amount of a steroid.

Abstract: Disclosed are biomedical implants comprising surface-modified metal particles and biodegradable polymers; its use for suppressing inflammation; and a method for preparing a biomedical material, comprising: (a) modifying surface of basic metal particles with a polymer to obtain surface-modified metal particles; and (b) mixing the surface-modified metal particles with a biodegradable polymer, followed by manufacturing a biodegradable biomedical implant, or coating the resulting mixture on a conventional biomedical implant.

Abstract: Fluid sample purification systems and methods are provided for isolating molecules of interest in a fluid sample. The fluid sample purification system has a housing with a distal end and distal opening adapted for the passage of a fluid and a proximal end and proximal opening adapted for passage of a fluid. A distal retainer is located inside the housing and above the distal opening. A proximal retainer is located inside the housing between the distal retainer and the proximal opening, or is located adjacent to, in contact with, or over the proximal opening. The system also comprises adsorption material, e.g., functionalized particles, inside the housing and confined between the distal retainer and the proximal retainer. The adsorption material adsorbs undesirable material while simultaneously rejecting desirable materials. Methods are also provided for isolating molecules of interest using the fluid sample purification system.

Abstract: Disclosed are compositions comprising collagen covalently bound to particles, wherein covalent bonds are formed between reactive groups of the collagen and reactive groups of the particles, and wherein the particles have an average particle diameter ranging from 20 to 1000 nanometers. Also disclosed are various methods that utilize the compositions.

Abstract: The present invention relates to a nanocrystalline photocatalyst active upon visible light irradiation, with a high degree of dispersion, stable in the form of a transparent colloidal solution in an aqueous environment, containing nanocrystals of titanium dioxide (TiO2) surface-modified via direct chemisorption of organic compounds. The present invention in turn relates to a method of producing the material as well as its use as a photosteriliser, photobacteriocide, photomycocide, and/or photocatalyst, in particular for the sterilisation of glass surfaces, transparent plastics and transparent materials, in particular contact lenses, medical catheters, glass and plastic conduits as well as other surfaces, whose sterilisation is desirable and/or required.

Abstract: A chemical mechanical polishing slurry composition, comprising, as initial components: water; an abrasive; a halogenated quaternary ammonium compound according to formula (I), wherein R8 is selected from a C1-10 alkyl group and a C1-10 hydroxyalkyl group; wherein X1 is a halide selected from chloride, bromide, iodide and fluoride; wherein R9, R10 and R11 are each independently selected from a saturated or unsaturated C1-10 alkyl group, a C1-10 haloalkyl group, a C6-15 aryl group, a C6-15 haloaryl group, a C6-15 arylalkyl group and a C6-15 haloarylalkyl; and, wherein the anion in formula (I) can be any anion that balances the + charge on the cation in formula (I); and, optionally, a diquaternary substance according to formula (II), wherein each A is independently selected from N and P; wherein R1 is selected from a saturated or unsaturated C1-C15 alkyl group, a C6-C15 aryl group and a C6-C15 aralkyl group; wherein R2, R3, R4, R5, R6 and R7 are each independently selected from selected from a hydrogen, a satura

Abstract: The present disclosure relates to a magnetic toner composition. The toner composition includes one or more resins, and spherical ferromagnetic nanoparticles. Also provided is a process for preparing these toners including ferromagnetic nanoparticles. In embodiments, the aggregation of the toner is conducted at a pH greater than about 7, without the use of a coagulant. Additionally, in embodiments, freezing (stopping particle growth) and coalescence of the toner particles may be conducted at a pH greater than about 9. In yet other embodiments, the process may be conducted under an inert gas such as argon to avoid oxidation of the ferromagnetic nanoparticles during toner preparation.

Abstract: The present invention generally relates to yeast cell wall microparticles loaded with nanoparticles for receptor-targeted nanoparticle delivery. In particular, the present invention relates to trapping nanoparticles either on the surface or inside a yeast glucan particles, for example, yeast glucal particles. The present invention further relates to methods of making the yeast cell wall particles loaded with nanoparticles. The present invention also relates to methods of using the yeast cell wall particles loaded with nanoparticles for receptor-targeted delivery of the nanoparticles, e.g., drug containing nanoparticles.

Abstract: Preparation of Free-Flowing Organosilica Nanoparticles by Forming a solution of an organosilica nanoparticle precursor in a mixed solvent system comprising a first solvent and a second solvent, wherein the first solvent is different from the second solvent, wherein the second solvent has a boiling point which is greater than a boiling point of the first solvent, and wherein the nanoparticle precursor has a greater solubility in the first solvent than in the second solvent; removing at least 50% of the first solvent to form nanoparticles having a mean particle size less than about 25 nanometers dispersed in the solution; adding a coupling agent to the solution to facilitate reacting of the coupling agent with the nanoparticles; and recovering the nanoparticles from the solution, wherein the recovered nanoparticles have the mean particle size of less than about 25 nanometers

Abstract: The present invention is directed to a method of detecting presence or absence of a target nucleic acid using negatively charged metallic nanoparticles dissolved in a solution. A nucleic acid probe with a substantially neutral net charge is used for detecting the target nucleic acid. The present invention is also directed to a kit including at least one nucleic acid probe with a substantially neutral net charge and at least one type of negatively charged metallic nanoparticles for carrying out the method.

Abstract: The present invention is directed to nanoparticle-based targeted drug delivery system for treatment of bone-loss. An enantiomeric phenothiazine is formulated into an in-vivo nanoparticle delivery system which may contain bone-targeting functionality. The nanoparticle formulations and their associated influence on whole bone porosity may now also be evaluated utilizing nuclear magnetic resonance (NMR) and relaxation time profiles, and in particular, median T2 relaxation times.

Abstract: The present invention relates to a pigmented coating composition for an automobile clear coat, to the use of a coating composition of this type, to an automobile clear coat, and to a process for the coating of an automobile with a clear coat.

Abstract: The present invention relates to an assay for transferases. The assay comprises a first moiety comprising a transferase substrate and a second moiety capable of binding to the transferase substrate after it has been acted on by the transferase. One of the first and second moieties comprises a fluorophore and the other of the first and second moieties causes a change in fluorescence of the fluorophore. Thus, when the second moiety binds the transferase substrate after it has been acted on by the transferase, a change in fluorescence can be detected. The assay allows for agents that modulate the activity of the transferase to be screened.

Abstract: Disclosed is a composition immunologically targeted to Alzheimer's disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an amyloid-beta antigen associated with AD. The invention also includes a medication manufactured with the targeted nanoceria particles and methods of treatment by administering the targeted nanoceria particles to patients in need thereof.

Abstract: A graphene light-emitting device and a method of manufacturing the same are provided. The graphene light-emitting device includes a p-type graphene doped with a p-type dopant; an n-type graphene doped with an n-type dopant; and an active graphene that is disposed between the type graphene and the n-type graphene and emits light, wherein the p-type graphene, the n-type graphene, and the active graphene are horizontally disposed.

Abstract: Compositions that include a clay such as kaolin dispersed in a liquid such as water may be useful for promoting the clotting of blood. The compositions may be in a liquid, gel, paste, foam, or another form. Uses may include treating a traumatic injury such as in injury caused by a bullet, an explosive, a blade etc., or an injury caused during a medical procedure such as surgery.

Abstract: The present invention relates to articles and gloves having a polymer coating on at least a portion of the article or gloves's surface, wherein the polymer coating comprises a polyurethane dispersion made from the reaction product of an isocyanate functional prepolymer, a chain extender, and a chain terminator; and methods for making the same. The articles and gloves of the present invention have improved flexibility, breathability, dexterity and feel, and provide self-sanitizing and self-deodorizing capabilities and improved non-slip grip performance in dry, wet, humid and lubricated conditions.

Abstract: The present invention relates to a pharmaceutical composition comprising a pharmaceutical agent and a pharmaceutically acceptable carrier, which carrier comprises a protein, for example, human serum albumin and/or deferoxamine. He human serum albumin is present in an amount effective to reduce one or more side effects associated with administration of the pharmaceutical composition. The inventor also provides methods for reducing on or more side effects of administration of the pharmaceutical composition, and methods for enhancing transport and binding of a pharmaceutical agent to a cell.

Abstract: A method for making a polymer composite comprises mixing, a thermosetting polymer precursor, and 0.01 to 30 wt % of a derivatized nanoparticle based on the total weight of the polymer composite, the derivatized nanoparticle including functional groups comprising carboxy, epoxy, ether, ketone, amine, hydroxy, alkoxy, alkyl, aryl, aralkyl, alkaryl, lactone, functionalized polymeric or oligomeric groups, or a combination comprising at least one of the forgoing functional groups.

Abstract: The present invention relates to methods for functionally modifying a polymeric surface for subsequent deposition of metallic particles and/or films, wherein the polymeric surface is modified by increasing hydroxyl and/or amine functional groups thereby providing an activated polymeric surface for deposition of metallic particles to form a fluorescence sensing device. The device can be used for metal-enhanced fluorescence of fluorophores positioned above the metallic particles that can be readily applied to diagnostic or sensing applications of metal-enhanced fluorescence.

Abstract: A new technique to stabilize transition metal phosphors in a wide variety of stimuli-sensitive polymers and gels is disclosed herein. Other than stabilization in stimuli sensitive/biocompatible matrix some of these transition metal based phosphors are also shown to act as phosphorescent crosslinkers that physically or chemically crosslink polymeric chains to form micro/nanoparticles. The microspheres/nanospheres of the present invention show decreased size and photoluminescence enhancement with particularly high sensitization at physiological pH and temperature. The so formed phosphorescent micro/nanospheres are useful for biological or environmental applications including biological labeling, imaging, and optical sensing. The techniques in the present invention enable usage of imaging agents and sensors at very low concentrations and also minimize or eliminate the usage of toxic chemical crosslinkers typically used to synthesize polymeric micro/nanoparticles.

Abstract: An ultraviolet-curable pressure-sensitive adhesive composition, comprising one or more monomer components comprising an acrylic monomer; an aromatic low-molecular-weight polymer having a weight-average molecular weight of 500 to 4000 inclusive, the molecular weight being according to gel permeation chromatography; and a photopolymerization initiator; wherein when the composition is turned into a pressure-sensitive adhesive layer, the haze value of the composition is 10% or less.

Abstract: Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof. The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.

Abstract: The present invention discloses an inorganic/organic mixed component (I/O) dispersant and applications thereof, which is primarily applied to dispersing nanoparticles of metal oxides. The I/O dispersant of the present invention can be a composite of inorganic clay and an organic surfactant, a composite of inorganic clay and polyoxyalkylene-amine, or a composite of inorganic clay, polyisobutylene succinic anhydride (PIB-SA) and hydrochloric acid salt or tetraalkyl quaternary salt of polyoxyalkylene-amine, or fatty amines. By mixing with the I/O dispersant of the present invention, nanoparticles of a metal oxide can be uniformly dispersed without aggregation particularly at high solid content. The dispersion has a lower viscosity and is relatively stable in storage even at high temperature.

Abstract: This disclosure relates to structures for the conversion of light into energy. More specifically, the disclosure describes devices for conversion of light to electricity using photovoltaic cells layered with a nanostructure that resonates and undergoes Whispering Gallery Mode.

Abstract: The present invention relates to a process for the production of nanoparticles or nanostructured particles with the help of a 2-emulsion method, particles being produced through targeted coalescence of miniemulsions in a high-pressure homogenized.

Abstract: A solar cell structure includes silicon nano-particle diffusion regions. The diffusion regions may be formed by printing silicon nano-particles over a thin dielectric, such as silicon dioxide. A wetting agent may be formed on the thin dielectric prior to printing of the nano-particles. The nano-particles may be printed by inkjet printing. The nano-particles may be thermally processed in a first phase by heating the nano-particles to thermally drive out organic materials from the nano-particles, and in a second phase by heating the nano-particles to form a continuous nano-particle film over the thin dielectric.

Abstract: A platinum-containing catalyst that is able to optimize state density of platinum 5d vacant orbital and is able to improve catalyst activity and a fuel cell using the same are provided. In the platinum-containing catalyst, when ratio of a peak intensity of a PtLIII absorption edge of a normalized X-ray absorption spectrum of the platinum-containing catalyst with respect to a peak intensity of a PtLIII absorption edge of a normalized X-ray absorption spectrum of a platinum simple substance metal foil having a thickness of 10 ?m is Y, the number of holes of a platinum 5d vacant orbital in the platinum simple substance metal foil is 0.3, the number of holes of a platinum 5d vacant orbital in the platinum-containing catalyst is N, and molar ratio of total of metal elements other than platinum to the platinum in the platinum-containing catalyst is X, Y=0.144X+1.060 is established in the range of 0.1?X?1, and N=0.030X+0.333 is established in the range of 0.1?X?1.

Abstract: The present invention relates to supported Ni-catalysts optionally comprising Zn as a promoter, methods for the production of said catalysts and uses of said catalysts for the hydrogenation of a hydrocarbon feed.

Abstract: Disclosed are a composite electrode active material and a supercapacitor using the same, and more particularly, an electrode active material having M1-xRuxO3 (M=Sr, Ba, Mg) and a supercapacitor using the same, wherein the electrode active material is characterized by comprising M1-xRuxO3, where M is at least one selected from a group consisting of strontium, barium and magnesium, and a method for fabricating a composite electrode active material comprises (a) preparing a spinning solution containing a precursor of M oxide, a precursor of Ru oxide, a polymer and a solvent, (b) spinning the spinning solution on a collector to fabricate a nanofiber web having M1-xRuxO3 precursor, and (c) performing heat treatment for the nanofiber web to remove the polymer so as to make an electrode active material in the structure of porous nanofiber web having M1-xRuxO3, wherein the M comprises at least one selected from a group consisting of strontium, barium and magnesium.

Abstract: A non-sintered structure. The non-sintered structure includes a first non-sintered nanocrystal layer, and a second non-sintered nanocrystal layer wherein the first layer and the second layer are configured to interact electronically.

Abstract: This invention relates to compositions and methods that can be used immunize a subject against influenza. Generally, the compositions and methods include peptides obtained or derived from human influenza A virus hemagglutinin.

Abstract: Composite nanogranules from polymer/inorganic nanoparticle, especially first composite nanogranules which are formed from first polymer and inorganic nanoparticles, second composite nanogranules which are obtained by forming second polymer on the first composite nanogranules, third composite nanogranules which is obtained by forming third polymer on the second composite nanogranules, and Nth composite nanogranules which is obtained by forming Nth polymer on the (N?1)th composite nanogranules with the similar method, are disclosed. A composition comprising anyone of the composite nanogranules described above is disclosed. The preparation method thereof and use of the same are also disclosed.

Abstract: The present invention concerns antiglare films having a microstructured surface.

Abstract: This invention relates to a polymeric pharmaceutical dosage form for the delivery, in use, of at least one pharmaceutical composition in a rate-modulated and site-specific manner. The dosage form comprises a biodegradable, polymeric, scaffold incorporating loaded with at least one active pharmaceutical ingredient (API). The polymer or polymers making up the scaffold degrade in a human or animal body in response to or in the absence of specific biological stimuli and, on degradation, release the API or APIs in an area where said stimuli are encountered. Preferably the polymeric scaffold is formed from poly (D1L-lactide) (PLA) and polymethacrylate (Eudragit S100/ES100) polymers.

Abstract: A method is disclosed of producing stable nanosized colloidal suspensions of particles with limited crystallinity loss, products thereof, use of the products and an apparatus for the method. In particular the present invention relates to a wet milling method with small beads wherein the size of the final particles in suspension are stabilized in the nanorange (D50<75 nm) and at the same time the particles substantially maintain the crystallinity.

Abstract: An ink composition includes an aqueous dispersion of particles of a first material and separate particles of a second material. The first material contains an oxide, sulfide, or selenide of a magnetic metal. The ink is formulated to exhibit, after application to a solid substrate, a degree of metallic luster enhanced by the presence of the second material.

Abstract: A polymer nanocomposite comprises a polymer; and a nanoparticle derivatized to include functional groups including carboxy, epoxy, ether, ketone, amine, hydroxy, alkoxy, alkyl, aryl, aralkyl, alkaryl, lactone, functionalized polymeric or oligomeric groups, or a combination comprising at least one of the forgoing functional groups. The variability in tensile strength and percent elongation for the polymer nanocomposite is less than the variability of these properties obtained where an underivatized nanoparticle is included in place of the derivatized nanoparticle.

Abstract: The present invention provides nanoparticulate nimesulide compositions. The compositions preferably comprise nimesulide and at least one surface stabilizer adsorbed on or associated with the surface of the nimesulide particles. The nanoparticulate nimesulide particles preferably have an effective average particle size of less than about 2000 nm. The invention also provides methods of making and using nanoparticulate nimesulide compositions.

Abstract: Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds.

Abstract: Glycoconjugate vaccines and methods of preparing and using the same are described.

Abstract: Fine particles of crystalline polyol are provided having a cationic polymer fixed on the crystal surfaces. These fine particles can stably carry an anionically charged compound on their surfaces.

Abstract: The present invention provides means and methods for producing surface-activated semiconductor nanoparticles suitable for in vitro and in vivo applications that can fluoresce in response to light excitation. Semiconductor nanostructures can be produced by generating a porous layer in semiconductor substrate comprising a network of nanostructures. Prior or subsequent to cleavage from the substrate, the nanostructures can be activated by an activation means such as exposing their surfaces to a plasma, oxidation or ion implantation. In some embodiments, the surface activation renders the nanostructures more hydrophilic, thereby facilitating functionalization of the nanoparticles for either in vitro or in vivo use.

Abstract: A reaction is carried in a gaseous phase between ammonia (NH3) and boron trifluoride (BF3) in a cooled reactor under atmospheric pressure. A boron trifluoride-ammonia complex (NH3.BF3) obtained in this reaction is thermally decomposed at a temperature in the range of 125 to 300° C. into boron nitride and ammonium tetrafluoroborate in accordance with the following scheme: 125-300° C. 4NH3.BF3?BN+3NH4.BF4 BN is then separated from the mixture of BN with 3NH4.BF4 by combining the mixture with deionized water, forming a suspension, and separating the suspended BN nanoparticles by centrifugation.

Abstract: A modified compound that has at least one further functional group, in particular a bio- or macromolecule, comprising at least one x-fold (x?1) chemoselectively incorporated phosphoramidate group of general formula (I), NPO(OR1) (OR1?), and/or at least one x-fold (x?1) chemoselectively incorporated phosphonamide group of general formula (Ia), NPO(R1)(OR1?). R1 and R1? is selected from the group containing glycerol, polyglycerol, PEG polymers of the general empirical formula C2nH4n+2On+1 with n?1, Cn-alkyl chains with n?1; functionalized Cn-alkyl chains with n?1, aryls, heteroaryl, silyl, lipids, fluorophores, saccharides, peptides, crown ethers, or a linker, which links the aforementioned groups. R1 and R1? can be identical to or different from one another.

Abstract: The present invention provides a composition including a polymer nanoparticle and at least one agricultural active compound incorporated with the nanoparticle, wherein the nanoparticle are less than 100 nm in diameter, and the polymer includes a polyelectrolyte.

Abstract: A toner which contains: toner base particles having Dv of 4.0-6.0 ?m; and two or more additives on surfaces of the toner base particles, where the additives contains Additives A and B, wherein the toner base particles are obtained by the method containing: dispersing, in an aqueous medium, an oil phase in which at least one of a crystalline polyester resin and a non-crystalline polyester resin is contained in an organic solvent, to prepare a dispersion liquid; and removing the organic solvent from the dispersion liquid, and wherein the Additive A has the largest average primary particle diameter in the additives and has CA of 5-10% where the CA is determined by the formula A, and the Additive B has the smallest average primary particle diameter in the additives and has CB of 45-100% where the CB is determined by the formula B.

Abstract: A light emitting composition including first color emitters and second color emitters. The first color emitters are configured to emit, upon exposure to an energy source, visible light at a target color in response to absorption of energy across a first band of wavelengths. The second color emitters are configured to emit, upon exposure to the energy source, visible light at the target color in response to absorption of energy across a second band of wavelengths. The light intensity observable at the target color is enhanced relative to reflected white light without emission from the first and second color emitters. The light emitting composition can be a part of a paint, an ink, a fabric, a thread, a road sign, a highway marking, an automobile, a boat, a plane, a reflector, a building product, a concrete product, an epoxy product, a jewelry product, colored contact lens, a candle product, a rubber product, a plastic product, or other colored surface.