Abstract: Oral compositions including zinc and a coolant provide extended breath freshening without the poor taste and astringency associated with zinc containing compositions.
Abstract: The present invention relates to methods of using and compositions containing acrivastine which provide antihistaminic therapeutic benefits while minimizing undesirable central nervous system side effects. According to the present invention, the plasma concentration-response curve for acrivastine's sedative side effects is steeper than that of the plasma concentration-response curve for its antihistamine activity. Accordingly, when the peak blood plasma level of acrivastine is maintained within the levels provided by the present invention composition, the central nervous side effects are minimized while the antihistaminic effects are optimized.
Type:
Grant
Filed:
May 21, 1998
Date of Patent:
June 20, 2000
Assignee:
Warner-Lambert Company
Inventors:
Anthony Booth, Harvey Dickstein, Jeffrey R. Koup
Abstract: The present invention relates to novel liquid oral suspensions incorporated within a soft gelatin capsule comprised of a bitter or bad-tasting pharmaceutical active (such as antihistamines, decongestants and the like) which is dispersed within an adsorbate comprised of magnesium trisilicate, silicon dioxide or mixture thereof. The adsorbate is dispersed within an aqueous or non-aqueous carrier base and combined with other flavors, sweeteners, emulsifiers and the like. The adsorbate not only taste-masks the active but also insures that is evenly dispersed through the liquid suspension so that a uniform dosage rate is readily achievable. The encapsulation of the adsorbate within a gelatin capsule makes administration easier for children andmore convenient. The capsule also affords the adsorbate suspension greater shelf life.
Abstract: The present invention relates generally to a mixture of coated and non-coated sulfonic acid cation exchange resins (Amberlite IR69) cross-linked with about 8% divinyl benzene onto which dextromethorphan has been loaded. About 30% of the drug/resin complexes are coated with a mixture of ethyl cellulose or ethyl cellulose latexes with plasticizers and water dispersible polymers such as SURELEASE. The coating level is about 50% w/w drug. Coated and uncoated drug/resin complexes are loaded with drug to about 45% by weight drug/resin complex. The ratio of coated and uncoated drug/resin complexes is about 55/45. The particle sizes of the coated and uncoated drug/resin complexes is about 20 to about 300 and about 20 to about 250 microns, respectively.
Type:
Grant
Filed:
December 19, 1997
Date of Patent:
December 14, 1999
Assignee:
Warner-Lambert Company
Inventors:
Betty Wen, Michael P. Ramsay, Heinrich Scheurer, Val Dokuzovic, Vincent Lam
Abstract: An improved stable acidic antiseptic dentifrice composition with therapeutically effective amounts of essential oils formulated at a pH of between 3.0 and 5.5 is disclosed. Also disclosed is an improved stable acidic antiseptic and anticaries dentifrice composition with essential oils and one or more fluorine-releasing compounds, formulated at a pH of between 3.0 and 5.5.
Type:
Grant
Filed:
December 27, 1996
Date of Patent:
August 24, 1999
Assignee:
Warner-Lambert Company
Inventors:
D. Scott Harper, Rita M. Parikh, Dhananjaya Alli, Anil Talwar
Abstract: A process for making a fast melt tablet and a powdered material is disclosed. The process includes providing a powdered material with a density of from 0.2 to about 0.55 grams and precompacting the material to increase the density prior to compacting the powdered material into a fast melt tablet.
Abstract: An antimicrobial composition containing an alcohol having 3 to 6 carbon atoms which effectively increases antimicrobial activity and particularly a mouthwash composition that is useful in the prevention and reduction of bad breath, plaque and related gum diseases having an antimicrobially effective amount of one or more active essential oils; from about 0.01% to about 30.0% v/v of an alcohol having 3 to 6 carbon atoms; optionally, ethanol; at least one surfactant; and water. The actives not only provide enhanced efficacy but are completely solubilized, thus providing an aesthetically appealing product.
Type:
Grant
Filed:
October 10, 1996
Date of Patent:
April 6, 1999
Assignee:
Warner-Lambert Company
Inventors:
Pauline Pan, Edward Carlin, R. Michael Buch, Frank Volpe, Alain Martin
Abstract: An antiplaque and antigingivitis effective oral composition containing a stabilized N.sup..alpha. -acyl acidic amino acid ester salt is disclosed. Also disclosed is a method for inhibiting plaque buildup in the oral cavity with an oral composition containing the stabilized N.sup..alpha. -acyl acidic amino acid ester salt.
Type:
Grant
Filed:
December 8, 1997
Date of Patent:
February 23, 1999
Assignee:
Warner-Lambert Company
Inventors:
E. Eric Engelman, Lynn Schick, Mona Nair, R. Michael Buch
Abstract: A pleasant-tasting, substantially alcohol-free oral mouthwash composition is effective in eliminating the bacteria and other oral microflora responsible for the production of plaque, periodontitis, gingivitis, gum disease and bad breath. The composition consists of a unique blend of the essential oils thymol or eucalyptol, methyl salicylate, menthol and tripartite blend of peppermint flavor oils that are dissolved in solution using a non-ionic surfactant blend.
Type:
Grant
Filed:
January 28, 1997
Date of Patent:
October 6, 1998
Assignee:
Warner-Lambert Company
Inventors:
Atma Chaudhari, Heinrich Scheurer, Pauline Pan, Frank Volpe
Abstract: An anticalculus dentifrice composition containing an antimicrobially effective amount of an antimicrobial agent selected from the group consisting of thymol, eucalyptol, methyl salicylate and mixtures thereof, and a pyrophosphate ion in an amount from about 0.1% to less than about 1.5% by weight of the composition, the pyrophosphate ion being derived from a highly soluble alkali metal pyrophosphate salt. The composition exhibits both antimicrobial and anticalculus efficacy at low levels of pyrophosphate ion even in the substantial absence of anticalculus enhancing agents.
Type:
Grant
Filed:
February 5, 1997
Date of Patent:
September 22, 1998
Assignee:
Warner-Lambert Company
Inventors:
Dahsehn Yu, Anil K. Talwar, D. Scott Harper, Dhananjaya Alli
Abstract: Reduced alcohol antiseptic mouthwash compositions are achieved which have the same oral antimicrobial efficacy, clarity and taste as higher alcohol level compositions. Availability of the active ingredients is best maintained by increasing the levels of surfactant employed in the composition together with the addition of two co-solvents, propylene glycol and glycerin. Propylene glycol with artificial sweetener(s), or propylene glycol alone with corresponding increases in the levels of surfactant are only marginally acceptable.
Type:
Grant
Filed:
January 21, 1997
Date of Patent:
March 3, 1998
Assignee:
Warner-Lambert Company
Inventors:
R. Michael Buch, Thomas A. Biemer, Frank A. Volpe
Abstract: A chewable cold/sinus preparation comprising a bitter tasting mixture of a decongestant such as pseudoephedrine and an antihistamine such as diphenhydramine and/or chlorpheniramine maleate is made with no bitter, metallic taste or unpleasant mouthfeel by adsorbing the active drug mixture using a wet granulation process onto a silicon dioxide carrier which comprises from about 50 to about 85% of total weight of the adsorbate composition. A truly multi-symptom relief formula is prepared through the optional addition of an antitussive such as dextromethorphan hydrobromide and/or an analgesic such as meclofenamic acid, aspirin or ibuprofen. Additional excipients such as flavors, sweeteners, lubricants and bulk fillers are added for better taste, improved mouthfeel and as an aid to the tabletting process.
Type:
Grant
Filed:
September 19, 1995
Date of Patent:
October 28, 1997
Assignee:
Warner-Lambert Company
Inventors:
Stanley Lech, Alexander M. Schobel, John Denick, Jr.