Patents Examined by William H. Beisner
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Patent number: 11499133Abstract: The present invention provides a cell treatment apparatus capable of treating cells in a cell culture vessel. The cell treatment apparatus 100 according to the present invention includes a first region 1, a second region 3, and a third region 5. The first region 1 and the second region 3 are placed in succession. The first region 1 is a cell treatment chamber for treating cells. The cell treatment chamber can be closed from the outside of the cell treatment chamber and includes a culture vessel placement portion for placing a cell culture vessel. The second region 3 includes: a laser irradiation device capable of irradiating the cell culture vessel placed in the culture vessel placement portion with a laser; and a spot diameter adjustment device that adjusts a spot diameter formed in a portion to be irradiated with the laser in an object to be irradiated.Type: GrantFiled: September 20, 2017Date of Patent: November 15, 2022Assignee: KATAOKA CORPORATIONInventors: Junichi Matsumoto, Shoichi Honda
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Patent number: 11499129Abstract: A cell treatment apparatus capable of treating cells in a cell culture vessel. The cell treatment apparatus (100) according to the present invention includes a first region (1), a second region (3), and a third region (5). The first region (1) and the second region (3) are placed in succession. The first region (1) is a cell treatment chamber for treating cells. The cell treatment chamber can be closed from the outside of the cell treatment chamber and includes a culture vessel placement portion for placing a cell culture vessel. The second region (3) includes a laser irradiation device capable of irradiating the cell culture vessel placed in the culture vessel placement portion with a laser. The third region (5) includes a control device that controls at least one device in the cell treatment apparatus (100) and a power supply device (52) that supplies electric power to at least one device in the cell treatment apparatus (100).Type: GrantFiled: September 20, 2017Date of Patent: November 15, 2022Assignee: KATAOKA CORPORATIONInventors: Junichi Matsumoto, Norihiro Yamagishi
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Patent number: 11491483Abstract: Devices for high throughput cell electroporation include a trapping component that at least partially defines an upper boundary of a microfluidic chamber. A cell trap array is patterned on the underside of the trapping component, and a channeling component is positioned beneath the trapping component. The channeling component includes a vertically oriented nanochannel array. The trapping component and the channeling component are positioned such that a given nanochannels is positioned beneath a cell trap. During use, fluid flow holds trapped cells in secure contact with the nanochannels beneath the cell trap. The device further includes upper and lower electrode layers for generating an electric field to electroporate trapped cells via the nanochannel array. A reservoir positioned beneath the channeling component can be filled transfection reagent solution. During electroporation, the transfection reagent solution travels through the nanochannel array during to transfect the trapped cells.Type: GrantFiled: February 15, 2019Date of Patent: November 8, 2022Assignee: Ohio State Innovation FoundationInventors: L. James Lee, Junfeng Shi
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Patent number: 11485943Abstract: Aspects of the disclosure relate to rotating bioreactors and articles and methods that are useful for adapting a rotating bioreactor for use with tissues or scaffolds of different sizes. In some embodiments, bioreactors comprising a reservoir and an arbor assembly are provided herein, in which the arbor assembly comprises a rotatable support to which a tissue or tissue scaffold can be attached.Type: GrantFiled: October 25, 2019Date of Patent: November 1, 2022Assignee: Biostage, Inc.Inventor: Herbert Hedberg
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Patent number: 11485941Abstract: The invention relates to a bioreactor including: a light source (200); a light sensor (300) facing said light source; a vat (100) that is placed between the light source (200) and the light sensor (300), said vat being intended to receive a culture medium comprising a cellular culture of photosynthetic microorganisms; a controller (400) connected to the light sensor (300) in order to control the vat (100) to obtain a chosen cellular-culture concentration (xi) in the culture medium during a working period, said light source (200) being capable of emitting incident light (L) of an input light intensity (Iin) in the direction of the vat (100), and the light sensor (300) being capable of measuring an output light intensity (Iout) and of transmitting data relating to this intensity (Iout) to the controller for the control of the vat; and a system (500) for controlling the light source (200), this system being arranged to adjust, during a period shorter than or equal to said working period, the input light intensitType: GrantFiled: April 3, 2017Date of Patent: November 1, 2022Inventors: Francis Mairet, Olivier Bernard, Hubert Bonnefond, Antoine Sciandra, Éric Pruvost
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Patent number: 11473049Abstract: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.Type: GrantFiled: September 9, 2019Date of Patent: October 18, 2022Assignee: CLAREMONT BIOSOLUTIONS, LLCInventors: Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine
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Patent number: 11465143Abstract: A reaction processing vessel includes a substrate and a groove-like channel formed on the upper surface of the substrate. The channel includes a high temperature serpiginous channel, a medium temperature serpiginous channel, and a high temperature braking channel and a medium temperature braking channel that are adjacent to the high temperature serpiginous channel and the medium temperature serpiginous channel, respectively. The respective cross-sectional areas of the high temperature braking channel and the medium temperature braking channel are larger than the respective cross-sectional areas of the high temperature serpiginous channel and the medium temperature serpiginous channel, respectively.Type: GrantFiled: April 23, 2020Date of Patent: October 11, 2022Assignee: Nippon Sheet Glass Company, LimitedInventors: Hidemitsu Takeuchi, Osamu Kawaguchi, Takashi Fukuzawa
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Patent number: 11459537Abstract: A sensor device according to the present technology includes a stack sensor. The stack sensor includes a first sensor layer and a second sensor layer. The first sensor layer has, as a detection target, a first substrate in a culture solution, the first substrate being changed in accordance with a change in a state of a cell. The second sensor layer has, as a detection target, a second substrate in the culture solution and is provided on the first sensor layer, the second substrate being changed in accordance with the change in the state.Type: GrantFiled: April 19, 2018Date of Patent: October 4, 2022Assignee: Sony CorporationInventors: Ichiro Takemura, Daisuke Yamaguchi, Yoshio Goto, Kyohei Yoshimitsu
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Patent number: 11447730Abstract: A bioreactor system includes a vessel having a bottom floor, a flexible bioprocessing bag disposed within the vessel, and a flexible bladder positioned intermediate the bottom floor of the vessel and the bioprocessing bag. The flexible bladder is selectively inflatable to vary at least one of a geometry or configuration of the bioprocessing bag to provide for improved drainability or an increased turndown ratio for the bioreactor system.Type: GrantFiled: May 30, 2018Date of Patent: September 20, 2022Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventor: Alexander Mark Kilar
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Patent number: 11441121Abstract: A spheroid cell culture article including: a frame having a chamber including: an opaque side wall surface; a top aperture; a gas-permeable, transparent bottom; and optionally a chamber annex surface and second bottom, and at least a portion of the transparent bottom includes at least one concave arcuate surface, is disclosed. Methods of making and using the article are also disclosed.Type: GrantFiled: September 19, 2017Date of Patent: September 13, 2022Assignee: CORNING INCORPORATEDInventors: Scott Matthew Bennett, Brian Robb Douglass, Paul Ernest Gagnon, Jr., Gregory Roger Martin, Paul Michael Szlosek, Allison Jean Tanner
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Patent number: 11441114Abstract: A liquid feed device that feeds a liquid medium and a cell suspension to target containers by respectively suited liquid feed methods is provided. A pump 6 is connected between a first liquid bottle 12 containing a liquid medium and a second liquid bottle 2 containing a cell suspension, and a receptacle 8 to be used as a culture container is connected downstream of a second liquid bottle 12. The liquid medium in the first liquid bottle is sent to the receptacle through the pump 6 and a branch point 20 by opening a first supply valve 17, and the cell suspension in the second liquid bottle is sent to the receptacle by opening a first gas introducing valve 10, a second gas introducing valve 15, and a second supply valve 19 and transferring, by pressure, a gas supplied from the first gas introducing valve 10 to the second liquid bottle through the pump 6 and a branch point 16.Type: GrantFiled: February 24, 2017Date of Patent: September 13, 2022Assignee: Hitachi, Ltd.Inventors: Masaharu Kiyama, Guangbin Zhou, Daisuke Suzuki, Midori Kato, Hikaru Saito
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Patent number: 11434456Abstract: The present invention relates to a large-scale photosynthetic bioreactor in which transparent photobioreactors including a baffle are connected in parallel or in series by an adhesive element so that the reactor volume can be easily scaled up for scale-up culture of photosynthetic organisms, and to a fabrication method thereof. The large-scale photosynthetic bioreactor according to the present invention makes it possible to culture a larger amount of microalgae than a conventional photobioreactor in the same area. In addition, it has high light transmittance, produces a large amount of biomass per unit area due to smooth mixing, and has a significant effect of reducing carbon dioxide. Furthermore, the present invention has an advantage in that the number of photosynthetic bioreactors required to culture the same scale of photosynthetic organisms is significantly smaller than that in a conventional process for culture of photosynthetic organisms, and thus the operating costs can be reduced.Type: GrantFiled: September 28, 2018Date of Patent: September 6, 2022Assignee: Korea University Research and Business FoundationInventors: Sang Jun Sim, Hoang Minh Pham, Byung-Sun Yu, Jeongseop Lee, Young Joon Sung
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Patent number: 11432543Abstract: An organ preservation system includes a housing, an organ perfusion circuit disposed within the housing, and a dual direction bubble trap disposed within the organ perfusion circuit. The dual direction bubble trap can include an upper interior chamber, a lower interior chamber, an air vent valve, and a hydrophobic membrane disposed between the upper interior chamber and the air vent valve. During operation, when fluid is pumped by a fluid pump into the dual direction bubble trap from either a retrograde or antegrade direction, air passes through the hydrophic membrane and is vented through the air vent valve until such time that the interior chamber is full of fluid which causes the air vent valve to close. Related apparatus, systems, techniques and articles are also described.Type: GrantFiled: October 6, 2021Date of Patent: September 6, 2022Assignee: BRIDGE TO LIFE LTD.Inventors: Lawrence R. Jones, Kenneth E. Marte, David W. Wright
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Patent number: 11427851Abstract: A fluidic device has a culture chamber configured to house a 3D culture matrix comprising a culture of microorganisms. A concentration gradient of a test substance is established over the 3D culture matrix by providing respective fluid flows at different end portions of the culture chamber and comprising different concentrations of the test substance. The response of the microorganisms to the test substance is determined based on the position of a border zone in the 3D culture matrix.Type: GrantFiled: October 22, 2019Date of Patent: August 30, 2022Assignee: GRADIENTECH ABInventors: Johan Kreuger, Sara Thorslund, Zhigang Wu
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Patent number: 11414642Abstract: Embodiments of the invention relate to a Disposable Bioprocess System including a Single-Use-Bioreactor, a Single-Use-Pump and a single-use micro-organism retention filter. Combined most suitable for cultivation of suspended micro-organisms in a liquid media at high micro-organism concentration in a perfusion mode continuous process for expression of biological material. The inlet port of the liquid Single-Use-Pump connects via a valve to the broth reservoir of the Single-Use-Bioreactor through a liquid conveying port. The outlet port of the liquid pumping Single-Use-Pump connects via a valve to a micro-organism retention filter. And a method for operating said sterile Disposable Bioprocess System in perfusion mode for continuously processing.Type: GrantFiled: May 17, 2016Date of Patent: August 16, 2022Assignee: STOBBE GMBHInventor: Per Stobbe
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Patent number: 11406102Abstract: The present invention relates generally to tissue container systems that find use in the transport of tissues and methods of using the tissue container systems. In particular the present invention relates to systems that support the transport, thawing and use of cryopreserved human skin equivalents, and methods of their use by a health care provider.Type: GrantFiled: January 26, 2018Date of Patent: August 9, 2022Assignee: Stratatech CorporationInventors: Justin Koepsel, Ken Gratz
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Patent number: 11407967Abstract: A device (1) for accommodating a disposable container (44) has a receptacle (10) with at least one receptacle wall (16) that defines an interior of the receptacle (10) for accommodating the disposable container (44). The device includes a temperature control unit for controlling the temperature of the receptacle wall (16). A lighting device (50) is located on an inner face of the receptacle wall (16) that faces the interior of the receptacle (10) and that has the temperature controlled by the temperature control unit. The lighting device (50) is designed to emit light into the interior of the receptacle (10).Type: GrantFiled: October 21, 2016Date of Patent: August 9, 2022Assignee: Sartorius Stedim Biotech GmbHInventors: Jan Schaefer, Hannes Schmid
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Patent number: 11390838Abstract: The present invention provides a shake-type culture apparatus which can perform large scale culture without using stirring blades and a culture method using the same. More particularly, there are provided a shake-type culture apparatus comprising: a culture bag made from a soft packaging material; an outer shell container being arranged to house the entirety of the culture bag to be able to perform adjustment of a temperature thereof; and a power source for shaking the outer shell container housing the culture bag, wherein the contents in the culture bag can be stirred and mixed by shaking the outer shell container housing the culture bag; and a culture method using the same.Type: GrantFiled: January 27, 2016Date of Patent: July 19, 2022Assignee: FUJIMORI KOGYO CO., LTD.Inventor: Hiroyuki Matsuda
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Patent number: 11390841Abstract: A cell stretching device including a cell chamber having upper and lower portions is disclosed. The lower portion has fixing means for fixing a deformable cell substrate (S) to the cell chamber and defining a stretching region inside the chamber at the lower portion. The upper portion has stretching means movable relative to the chamber and acting on the cell substrate (S) and a support element for holding the stretching means and a driving unit coupled to the upper portion of the cell chamber and engageable to the stretching means for mechanically controlling and regulating the movement of the stretching means relative to the cell chamber. The stretching means include clip members operating inside the stretching region which are configured to clamp the cell substrate (S) at a clamping contact point and to stretch the cell substrate (S) in response to the movement.Type: GrantFiled: February 13, 2018Date of Patent: July 19, 2022Assignee: IFOM—FONDAZIONE ISTITUTO FIRC DI ON ONCOLOGIA MOLECOLAREInventor: Qingsen Li
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Polymerase chain reaction using a microfluidic chip fabricated with printed circuit board techniques
Patent number: 11383236Abstract: Techniques are provided for a microfluidic chip for performing a microfluidic reaction. The microfluidic chip includes a rigid layer, a first polymer layer that forms a first surface of a microfluidic chamber within the microfluidic chip, a first adhesive layer disposed between the rigid layer and the first polymer layer, and a second polymer layer that forms a second surface of the microfluidic chamber, and a first port connecting an exterior of the microfluidic chip to the microfluidic chamber through at least the rigid layer, the first polymer layer, and the first adhesive layer. A first self-sealing valve is formed in the first polymer layer and disposed within the first port, the first self-sealing valve configured to seal directly against the rigid layer through a first gap in the first adhesive layer in response to pressure from thermal expansion of a fluid within the microfluidic chamber.Type: GrantFiled: November 12, 2018Date of Patent: July 12, 2022Inventor: Christopher Walker