Patents by Inventor Horng Lin

Horng Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SEMICONDUCTOR MANUFACTURING SYSTEM AND CONTROL METHOD
    Publication number: 20190067042
    Abstract: A system includes a chamber, an inlet valve, and a control device. The chamber is configured to perform a semiconductor process. The inlet valve is coupled to the chamber and a facility water source. The control device is coupled to the inlet valve, and configured to at least partially close the inlet valve when the chamber is idle.
    Type: Application
    Filed: August 30, 2017
    Publication date: February 28, 2019
    Applicant: TAIWAN SEMICONDUCTOR MANUFACTURING CO., LTD.
    Inventor: Su-Horng LIN
  • Plasmid, method and kit thereof for producing heat labile enterotoxin B-subunit
    Patent number: 10208093
    Abstract: The present invention provides a plasmid, method and kit for producing heat labile enterotoxin B-subunit based on a Bacillus subtilis expression system. By comparing with the conventional method in the art, the present invention has the advantages of high safety, good yield, and simplified process and is therefore favorable for the commercialization object of heat labile enterotoxin B-subunit in the application of vaccine adjuvant.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: February 19, 2019
    Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jiunn-Horng Lin, Jyh-Perng Wang, Chien-Yu Fang, Zeng-Weng Chen, Ming-Wei Hsieh, Hao-Zhen Zeng, Jian-Fong Lai, Weng-Zeng Huang, Tzu-Ting Peng
  • Bottom-up PEALD proces
    Patent number: 10121653
    Abstract: The present disclosure relates to a method and apparatus for performing a plasma enhanced ALD (PEALD) process that provides for improved step coverage. The process introduces a precursor gas into a processing chamber comprising a semiconductor workpiece. The first gas is ionized to form a plurality of ionized precursor molecules. A bias voltage is subsequently applied to the workpiece. The bias voltage attracts the ionized precursor molecules to the workpiece, so as to provide anisotropic coverage of the workpiece with the precursor gas. A reactant gas is introduced into the processing chamber. A plasma is subsequently ignited from the reactant gas, causing the reactant gas to react with the ionized precursor molecules that have been deposited onto the substrate to form a deposited layer on the workpiece.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: November 6, 2018
    Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.
    Inventors: Lin-Jung Wu, Su-Horng Lin, Chi-Ming Yang
  • ENDOGLYCOSIDASE MUTANTS FOR GLYCOPROTEIN REMODELING AND METHODS OF USING IT
    Publication number: 20180298361
    Abstract: A mutant of Endos2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO:1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of EndoS2 has a low hydrolyzing activity and a high tranglycosylation activity, as compared to those of the wild-type EndoS2. A method for preparing an engineered glycoprotein using the mutant of EndoS2 includes coupling an activated oligosaccharide to a glycoprotein acceptor. The activated oligosaccharide is a glycan oxazoline.
    Type: Application
    Filed: June 18, 2018
    Publication date: October 18, 2018
    Applicants: Academia Sinica
    Inventors: Nan-Horng Lin, Lin-Ya Huang, Sachin S. Shivatare, Li-Tzu Chen, Chi-Huey Wong, Chung-Yi Wu, Ting Cheng
  • ANTIBODIES, BINDING FRAGMENTS, AND METHODS OF USE
    Publication number: 20180291109
    Abstract: The present disclosure relates to anti-SSEA4 antibodies and bindings fragments thereof comprising specific complementarity determining regions capable of high affinity binding to SSEA4 molecules and SSEA4-associated expressing tumor cells, such as breast cancer, pancreatic cancer, and renal cancer cells. The anti-SSEA4 antibodies and binding fragments induce ADCC or CDC effects in the targeted tumor cells and inhibit and/or reduce the cancer/tumor proliferation. The present disclosure also provides anti-SSEA4 antibodies and binding fragments thereof as a pharmaceutical composition for treating cancer. In addition, the anti-SSEA4 antibodies and binding fragments are useful in the diagnosis of cancers.
    Type: Application
    Filed: August 22, 2017
    Publication date: October 11, 2018
    Inventors: Nan-Horng LIN, Chiu-Chen HUANG, Chien-Yu CHEN, Kuo-Ching CHU, Chi-Huey WONG, Han-Chung WU
  • Panorama photographing method, panorama displaying method, and image capturing method
    Patent number: 10070048
    Abstract: A panorama photographing method, a panorama displaying method and an image capturing method are used in an electronic device. The photographing method includes the following steps. Firstly, a plurality of predefined target positions required to produce a panoramic image are determined. Then, a navigator comprising a plurality of indications representing the plurality of predefined target positions is shown. A plurality of target photographs corresponding to the plurality of predefined target positions are captured and appearance of the plurality of indications according to a capturing status of the plurality of target photographs is changed. Afterwards, the panoramic image is generated according to the plurality of target photographs.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: September 4, 2018
    Assignee: HTC CORPORATION
    Inventors: Ruey-Jer Chang, Scott Chien-Hung Liao, Chih-Wei Cheng, Horng-Lin Chen, Tsai-Hsin Liu, Tung-Peng Wu
  • Composition for preventing spp. infection
    Patent number: 10059749
    Abstract: The present invention provides proteins that are suitable to be used as the active ingredient in subunit vaccine against Mycoplasma spp. The present invention also provides a subunit vaccine made therefrom. Said proteins have been experimentally proved to have the capability of inducing sufficient immune response to avoid pigs from Mycoplasma spp. infection. Said vaccine may have one of said proteins as active ingredient; or may have two or more of said proteins and is formulated as a cocktail vaccine. The present vaccine not only is safer than the conventional vaccines but also has equal or even better immune efficiency than the conventional ones. Furthermore, fusion partners suitable for producing said proteins of high solubility are also proved, which can significantly reduce production cost.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: August 28, 2018
    Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jiunn-Horng Lin, Jyh-Perng Wang, Zeng-Weng Chen, Chien-Yu Fang, Ming-Wei Hsieh, Ping-Cheng Yang
  • EXPRESSION ELEMENT, EXPRESSION CASSETTE, AND VECTOR CONTAINING THE SAME
    Publication number: 20180216119
    Abstract: The present invention provides an expression element and an expression cassette to establish a novel vector therefrom. The expression element of the present invention has an effect of enhancing the expression level of the target gene so that is highly industrial valuable. Accordingly, the present vector is taken as a novel tool for genetic engineering.
    Type: Application
    Filed: December 29, 2014
    Publication date: August 2, 2018
    Applicant: Agricultural Technology Research Institute
    Inventors: Jiunn-Horng LIN, Jyh-Perng WANG, Zeng-Weng CHEN, Chien-Yu FANG, Hao-Zhen ZENG, Jian-Fong LAI, Weng-Zeng HUANG, Shih-Ling HSUAN
  • COMPOSITION FOR PREVENTING MYCOPLASMA SPP. INFECTION
    Publication number: 20180208629
    Abstract: The present invention provides proteins that are suitable to be used as the active ingredient in subunit vaccine against Mycoplasma spp. The present invention also provides a subunit vaccine made therefrom. Said proteins have been experimentally proved to have the capability of inducing sufficient immune response to avoid pigs from Mycoplasma spp. infection. Said vaccine may have one of said proteins as active ingredient; or may have two or more of said proteins and is formulated as a cocktail vaccine. The present vaccine not only is safer than the conventional vaccines but also has equal or even better immune efficiency than the conventional ones. Furthermore, fusion partners suitable for producing said proteins of high solubility are also proved, which can significantly reduce production cost.
    Type: Application
    Filed: March 14, 2018
    Publication date: July 26, 2018
    Applicant: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: JIUNN-HORNG LIN, JYH-PERNG WANG, ZENG-WENG CHEN, CHIEN-YU FANG, MING-WEI HSIEH, PING-CHENG YANG
  • QUINOXALINE COMPOUNDS, METHOD FOR PREPARING THE SAME AND USE THEREOF
    Publication number: 20180208561
    Abstract: A compound for treating a protein kinase-related disease or disorder having a structure of formula (I) wherein L is NR8 or O; R1, R2, R3, R4, R5, R6 and R7 are defined herein. Compounds of formula (I) are useful for inhibition of protein kinases.
    Type: Application
    Filed: June 15, 2015
    Publication date: July 26, 2018
    Applicants: Development Center for Biotechnology, DCB-USA LLC
    Inventors: Nan-Horng Lin, Chu-Bin Liao, Shao-Zheng Peng, Shih-Chieh Yen, Mann-Yan Kuo
  • Endoglycosidase mutants for glycoprotein remodeling and methods of using it
    Patent number: 10000747
    Abstract: A mutant of EndoS2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO: 1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of EndoS2 has a low hydrolyzing activity and a high tranglycosylation activity, as compared to those of the wild-type EndoS2. A method for preparing an engineered glycoprotein using the mutant of EndoS2 includes coupling an activated oligosaccharide to a glycoprotein acceptor. The activated oligosaccharide is a glycan oxazoline.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: June 19, 2018
    Assignees: Academia Sinica, CHO Pharma Inc.
    Inventors: Nan-Horng Lin, Lin-Ya Huang, Sachin S Shivatare, Li-Tzu Chen, Chi-Huey Wong, Chung-Yi Wu, Ting Cheng
  • Method of manufacturing a semiconductor structure
    Patent number: 10002780
    Abstract: A method of manufacturing a semiconductor structure includes providing a substrate, disposing a first semiconductive material over the substrate at a first temperature, disposing a second semiconductive material over the first semiconductive material at a second temperature, and disposing a third semiconductive material over the second semiconductive material at a third temperature, wherein a first interval between the first temperature and the second temperature is substantially same as a second interval between the second temperature and the third temperature.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: June 19, 2018
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY LTD.
    Inventors: Su-Horng Lin, Victor Y. Lu, Tsung-Hsi Yang
  • ANTIBODY-DRUG CONJUGATES
    Publication number: 20180133340
    Abstract: An antibody-drug conjugate (ADC) has a structure represented by Formula (I): [D2-L2-Cn2?yG2-Ab-Sg1?G1-L1-D1]x?? Formula (I) or a pharmaceutically acceptable salt thereof, wherein Ab is an antibody without glycans (i.e., the protein portion of an antibody); G1 and G2 are glycan moieties, which may be the same or different; Cn1 and Cn2 are conjugation moieties, which may be the same or different; L1 and L2 are linker moieties, which may be the same or different; D1 and D2 are drug units which may be the same or different; and x and y are independently an integer from 0 to 8, provided that x+y?0.
    Type: Application
    Filed: November 14, 2017
    Publication date: May 17, 2018
    Applicant: CHO Pharma Inc.
    Inventors: Nan-Horng Lin, Charng-Sheng Tsai, Ting-Chun Hung, Hong-Yang Chuang
  • Composition for preventing spp. infection
    Patent number: 9951109
    Abstract: The present invention provides proteins that are suitable to be used as the active ingredient in subunit vaccine against Mycoplasma spp. The present invention also provides a subunit vaccine made therefrom. Said proteins have been experimentally proved to have the capability of inducing sufficient immune response to avoid pigs from Mycoplasma spp. infection. Said vaccine may have one of said proteins as active ingredient; or may have two or more of said proteins and is formulated as a cocktail vaccine. The present vaccine not only is safer than the conventional vaccines but also has equal or even better immune efficiency than the conventional ones. Furthermore, fusion partners suitable for producing said proteins of high solubility are also proved, which can significantly reduce production cost.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: April 24, 2018
    Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jiunn-Horng Lin, Jyh-Perng Wang, Zeng-Weng Chen, Chien-Yu Fang, Ming-Wei Hsieh, Ping-Cheng Yang
  • ENDOGLYCOSIDASE MUTANTS FOR GLYCOPROTEIN REMODELING AND METHODS OF USING IT
    Publication number: 20180057804
    Abstract: A mutant of EndoS2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO: 1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of EndoS2 has a low hydrolyzing activity and a high tranglycosylation activity, as compared to those of the wild-type EndoS2. A method for preparing an engineered glycoprotein using the mutant of EndoS2 includes coupling an activated oligosaccharide to a glycoprotein acceptor. The activated oligosaccharide is a glycan oxazoline.
    Type: Application
    Filed: August 23, 2017
    Publication date: March 1, 2018
    Applicants: CHO Pharma Inc., Academia Sinica
    Inventors: Nan-Horng Lin, Lin-Ya Huang, Sachin S Shivatare, Li-Tzu Chen, Chi-Huey Wong, Chung-Yi Wu, Ting Cheng
  • Agarase, Composition Containing the Same, and Application thereof
    Publication number: 20180044654
    Abstract: The present invention provides a ?-agarase, a composition containing the same and applications thereof. The present ?-agarase provides the field a novel alternative and is favorable for the industrial utilities of the hydrolysis products of agarose. Furthermore, the present agarase is particularly modified for heterologous production by prokaryotic expression systems, and thereby is favorable for commercial use.
    Type: Application
    Filed: March 20, 2017
    Publication date: February 15, 2018
    Applicant: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: JIUNN-HORNG LIN, JYH-PERNG WANG, ZENG-WENG CHEN, HUI-JIE LIN, SHU-WEI CHANG, WENG-ZENG HUANG, JIAN-FONG LAI, SHIH-LING HSUAN
  • METHOD OF MANUFACTURING A SEMICONDUCTOR STRUCTURE
    Publication number: 20170338138
    Abstract: A method of manufacturing a semiconductor structure includes providing a substrate, disposing a first semiconductive material over the substrate at a first temperature, disposing a second semiconductive material over the first semiconductive material at a second temperature, and disposing a third semiconductive material over the second semiconductive material at a third temperature, wherein a first interval between the first temperature and the second temperature is substantially same as a second interval between the second temperature and the third temperature.
    Type: Application
    Filed: May 17, 2016
    Publication date: November 23, 2017
    Inventors: SU-HORNG LIN, VICTOR Y. LU, TSUNG-HSI YANG
  • SEMICONDUCTOR DEVICE AND FABRICATING METHOD THEREOF
    Publication number: 20170338149
    Abstract: A method of fabricating a semiconductor device includes: forming a trench on an insulating layer to expose a first conductive feature disposed under the insulating layer; forming a barrier layer over the insulating layer, a sidewall of the trench, and the first conductive feature; etching a bottom of the barrier layer to expose the first conductive feature; and forming a second conductive feature over an exposed portion of the first conductive feature.
    Type: Application
    Filed: May 17, 2016
    Publication date: November 23, 2017
    Inventor: SU-HORNG LIN
  • Anti-spp. subunit vaccine
    Patent number: 9775893
    Abstract: Provided in the present invention are anti-Mycoplasma spp. subunit vaccines, especially proteins suitable for being used as the active ingredient of the Mycoplasma spp. subunit vaccines, and a vaccine prepared therefrom. Upon experimenting, it is confirmed that the proteins can elicit an immune response having sufficient strength to avoid the infection of Mycoplasma spp. in pigs. The vaccine can comprise one of the aforementioned proteins as an active ingredient, or can comprise two or more of the proteins to form a form of cocktail vaccine. The vaccine of the present invention is not only more safe than conventional vaccines, but also has equivalent or even better immune effects.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: October 3, 2017
    Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jiunn-Horng Lin, Jyh-Perng Wang, Ming-Wei Hsieh, Zeng-Weng Chen, Chien-Yu Fang, Hsueh-Tao Liu, Ping-Cheng Yang
  • Anti-spp. subunit vaccine
    Patent number: 9757441
    Abstract: Provided in the present invention are anti-Mycoplasma spp. subunit vaccines, especially proteins suitable for being used as the active ingredient of the Mycoplasma spp. subunit vaccines, and a vaccine prepared therefrom. Upon experimenting, it is confirmed that the proteins can elicit an immune response having sufficient strength to avoid the infection of Mycoplasma spp. in pigs. The vaccine can comprise one of the aforementioned proteins as an active ingredient, or can comprise two or more of the proteins to form a form of cocktail vaccine. The vaccine of the present invention is not only more safe than conventional vaccines, but also has equivalent or even better immune effects.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: September 12, 2017
    Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jiunn-Horng Lin, Jyh-Perng Wang, Ming-Wei Hsieh, Zeng-Weng Chen, Chien-Yu Fang, Hsueh-Tao Liu, Ping-Cheng Yang