Abstract: Described is a method for screening an encoded chemical library, which library comprises a plurality of different chemical structures each releasably linked to an encoding tag, the method comprising the steps of: (a) providing said library of tagged chemical structures; (b) releasing each chemical structure from its tag to produce a plurality of free, tagless chemical structures (TCSs); (c) screening the TCSs by contacting them with a assay system under conditions whereby a spatial association between each TCS and its tag is maintained, to produce a plurality of different screened TCSs each spatially associated with its tag; and (d) identifying a screened TCS by decoding a tag that is spatially associated therewith.

Abstract: Process to associate a set of physical ports on a physical device with a set of software virtual interfaces. Process includes placing the set of software virtual interfaces to be associated with a set of N physical ports in an enabled state which has a first link state when no activation device is connected to a particular software virtual interface and a second link state when an activation device is connected to the particular software virtual interface. Connecting an activation device such as a loopback connector to a physical port to shift the software virtual interface to the second link state to map that particular physical port to that particular software virtual interface.

Abstract: A system for detecting a disease agent in a sample derived from a patient biofluid may comprise a receiver coupled to a communication network and a controller coupled to the receiver. The controller may comprise a processor and a memory. The controller may be configured to generate an infrared spectrum of the sample. The sample spectrum may comprise one or more sample spectral components, the sample spectral components comprising a sample wavenumber and a sample absorbance value. A set of reference spectral models may comprise one or more reference spectral components. The reference spectral components may comprise a reference wavenumber and a reference absorbance value. The reference spectral components may comprise one or more pathogen characteristics associated with sepsis. The one or more sample spectral components may be classified as pathogenic using the reference spectral models. Pathogen data may be generated using the classified sample spectral components.

Abstract: Filter assemblies are described and shown. Components, features and methods of assembly and use are described. Many of the principles relate to preferred cartridge configurations for engagement with selected housings. Selected optional features described can be used to provide indication to a service provider that a proper cartridge is not positioned appropriately in the housing for use.

Abstract: A system for monitoring and detecting the gait and other health related parameters of a user. One such parameter is monitoring of medication compliance and treatment session attendance done by a medication and liquid dispensing apparatus, which combines mechanical dispensing of medication. These parameters are provided in standard of care summaries to care providers, and are continually reported by the Optimum Recognition Blueprint as Standard of Care Summaries to care providers, as well as communicated to the end-user by the Virtual Caregiver Interface.

Abstract: The invention described herein relates to a method of detecting malaria comprising the steps of: (i) delivering an evanescent IR beam through said ATR substrate in contact with a patient blood sample; (ii) detecting IR radiation transmitted from the ATR substrate to produce a signal characteristic for one or more lipids in the sample, and (iii) processing said signal and a set of reference library spectra of lipids associated with malaria parasites in order to detect matches and quantify said one or more lipids in the sample. In contrast to the prior art, the present invention relies on detecting lipids instead of hemozoin.

Abstract: Apparatuses, systems, methods, and computer program products are disclosed for on die buffered non-volatile memory management. A method includes storing data in a first set of non-volatile memory cells. A method includes determining one or more attributes associated with data. A method includes determining whether to store data in a second set of non-volatile memory cells based on one or more attributes. A second set of non-volatile memory cells may be configured to store more bits per cell than a first set of non-volatile memory cells.

Abstract: A storage layer may over-provision physical storage resources of a storage medium by reserving a portion of the full physical storage capacity of the storage medium for use as reserve capacity. The reserve capacity may be used to prevent write stall conditions and/or for grooming operations, such as storage recovery, refresh, and the like. A reserve module may be configured to adapt the reserve capacity in accordance with, inter alia, operating conditions on the storage layer. The reserve module may be configured to dynamically modify the storage capacity available through the storage layer. A cache layer configured to cache data of a backing store on the storage layer, may be configured to add and/or remove cache entries in response to changes in the reserve capacity.

Abstract: Described is a method for identifying a gene which mediates antibiotic sensitivity or resistance in a target bacterium, the method comprising the steps of: (a) generating a pool of mutant target bacteria by transposon mutagenesis with an activating transposon (TnA), wherein the TnA comprises an outward-facing promoter (TnAP) capable of increasing transcription of a gene at or near its insertion site in the DNA of said target cells; (b) generating a control microdroplet library by encapsulating individual members of the pool of step (a) in microdroplets, the microdroplets comprising a volume of aqueous growth media suspended in an immiscible carrier liquid, each microdroplet comprising a single mutant target cell; (c)generating a test microdroplet library by encapsulating individual members of the pool of step (a) in microdroplets, the microdroplets comprising a volume of aqueous growth media containing the antibiotic and suspended in an immiscible carrier liquid, each microdroplet comprising a single mutant t

Abstract: A system for monitoring and detecting the gait and other health related parameters of a user. One such parameter is monitoring of medication compliance and treatment session attendance done by a medication and liquid dispensing apparatus, which combines mechanical dispensing of medication. These parameters are provided in standard of care summaries to care providers, and are continually reported by the Optimum Recognition Blueprint as Standard of Care Summaries to care providers, as well as communicated to the end-user by the Virtual Caregiver Interface.

Abstract: The invention described herein relates to a method of detecting malaria comprising the steps of: (i) delivering an evanescent IR beam through said ATR substrate in contact with a patient blood sample; (ii) detecting IR radiation transmitted from the ATR substrate to produce a signal characteristic for one or more lipids in the sample, and (iii) processing said signal and a set of reference library spectra of lipids associated with malaria parasites in order to detect matches and quantify said one or more lipids in the sample. In contrast to the prior art, the present invention relies on detecting lipids instead of hemozoin.

Abstract: Describe is a method for screening mutant prokaryotic cells to identify producers of a cytotoxic agent active against a target cell, the method comprising the steps of: (a) providing cells of a producer prokaryotic species; (b) generating a pool of mutant producer cells by transposon mutagenesis of the cells of step (a) with an activating transposon (TnA), wherein the TnA comprises an outward-facing promoter (TnAP) capable of increasing transcription of a gene at or near its insertion site in the DNA of said producer cells; (c) co-encapsulating individual members of the pool of step (b) with one or more target cells in microdroplets, the microdroplets comprising a volume of aqueous growth media suspended in an immiscible carrier liquid, thereby generating a library of microdroplets each comprising a single mutant producer cell and one or more target cell(s); (d) incubating the microdroplet library of step (c) under conditions suitable for co-culture of the single mutant producer cell and target cell(s) to pro

Abstract: Described is a method for identifying a gene which mediates antibiotic sensitivity or resistance in a target bacterium, the method comprising the steps of: (a) generating a pool of mutant target bacteria by transposon mutagenesis with an activating transposon (TnA), wherein the TnA comprises an outward-facing promoter (TnAP) capable of increasing transcription of a gene at or near its insertion site in the DNA of said target cells; (b) generating a control microdroplet library by encapsulating individual members of the pool of step (a) in microdroplets, the microdroplets comprising a volume of aqueous growth media suspended in an immiscible carrier liquid, each microdroplet comprising a single mutant target cell; (c)generating a test microdroplet library by encapsulating individual members of the pool of step (a) in microdroplets, the microdroplets comprising a volume of aqueous growth media containing the antibiotic and suspended in an immiscible carrier liquid, each microdroplet comprising a single mutant t

Abstract: A flexible die head for continuously extruding pipe may have a flexible ring mandrel (112). A second, open end (120) of the ring mandrel (112) near the die exit may be continuously and resiliently formed to a non-circular shape whilst extruding the pipe so as to provide an extrudate profile to counter slump in plastic pipe forming. Symmetric and asymmetric shapes may be formed by the ring mandrel (112). The second end (120) may be flexed or otherwise distorted by use of a flexing means (122). The ring mandrel (112) may also be necked in a circumferential portion to order to further improve the forming of non-circular shapes.

Abstract: Techniques are disclosed relating to writing data across multiple storage blocks in a storage device. In one embodiment, physical erase blocks in a bank of a storage device are erasable. Ones of the physical erase blocks may be associated with different respective communication channels. In such an embodiment, a data stripe may be written across a set of physical erase blocks such that the set of physical erase blocks includes physical erase blocks of different banks and includes physical erase blocks associated with different communication channels. In some embodiments, a request to read a portion of the data stripe may be received. In response to the request, a determination may be made that one of the set of physical erase blocks is unavailable to service the request. The request may then be serviced by reassembling data of the unavailable physical erase block.

Abstract: Systems, methods, and non-transitory computer-readable media can create a loop-enabled patch in a node-based computing environment graphical user interface, the loop-enabled patch comprising a first input field and a second input field. A plurality of first input values are received at the first input field, and a plurality of second input values are received at the second input field. A computing system iterates through the plurality of first input values and the plurality of second input values to automatically create a plurality of object instances based on the plurality of first input values and the plurality of second input values.

Abstract: Devices and methods are generally provided for indicating the location of a most recent strike on a face of a golf club. One exemplary embodiment of an impact indication device can include a patch that can be attached to the face of a golf club and can display the impact location of a most recent strike without displaying impact locations of previous strikes. The impact locations of previous strikes can be removed from the patch without the user having to do anything more than take another swing. In some embodiments, the device includes a yield-stress material that assist in displaying impact a most recent impact location without displaying previous impact locations. Other features that can allow patches to work in this fashion, as well as methods related to the same, are also provided. Further, disclosures pertaining to a mobile impact recorder are also provided.

Abstract: A cache and/or storage module may be configured to reduce write amplification in a cache storage. Cache layer write amplification (CLWA) may occur due to an over-permissive admission policy. The cache module may be configured to reduce CLWA by configuring admission policies to avoid unnecessary writes. Admission policies may be predicated on access and/or sequentiality metrics. Flash layer write amplification (FLWA) may arise due to the write-once properties of the storage medium. FLWA may be reduced by delegating cache eviction functionality to the underlying storage layer. The cache and storage layers may be configured to communicate coordination information, which may be leveraged to improve the performance of cache and/or storage operations.

Abstract: Disclosed is a method for characterizing the effect of an antibiotic on a bacterium, the method comprising the steps of: (a) generating a pool of mutant bacteria by transposon mutagenesis of a culture of said bacterium with an activating transposon (TnA) which comprises an outward-facing promoter (TnAP) capable of increasing transcription of a gene at or near its insertion site in the DNA of said bacterium; (b) growing bacteria from the mutant pool in the presence of different amounts of said antibiotic to produce two or more test cultures; (c) sequencing mRNA transcripts produced by TnAP in each of said test cultures to produce an mRNA transcript profile for each of the test cultures; and (d) comparing the mRNA transcript profiles of the test cultures.

Abstract: Disclosed is a process for producing a mutant bacterium which exhibits improved survival and/or growth under a selected growth condition, the process comprising the steps of: (a) generating a pool of mutant bacteria by transposon mutagenesis with an activating transposon (TnA), wherein the TnA comprises an outward-facing promoter (TnAP) capable of increasing transcription of a gene at or near its insertion site in the DNA of said bacterium; (b) growing bacteria from the mutant pool under the selected growth condition and under one or more reference conditions to produce two or more test cultures; and (c) sequencing mRNA transcripts produced by TnAP in each of said test cultures to produce an mRNA transcript profile for each of the test cultures; and (d) comparing the mRNA transcript profiles of the test cultures to identify a first class of genes which are disadvantageous for growth and/or survival under the selected growth condition and a second class of genes which are advantageous for growth and/or surviva