Oxygen Containing Patents (Class 436/127)
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Patent number: 7229836Abstract: The invention relates to a method for the detection and/or measurement of a phenol comprising: (a) contacting the sample to be tested with a polymer imprinted with the phenol or an analogue thereof; and (b) measuring binding of the phenol to the polymer. The polymer may be prepared by polymerizing a polymerizable monomer, to which a phenol is covalently bound by a hydrolysable linker, and subsequently removing the phenol by hydrolysis. Propofol is a preferred phenol for use in the invention.Type: GrantFiled: June 29, 2001Date of Patent: June 12, 2007Assignee: The Horticulture and Food Research Institute of New Zealand LimitedInventors: Miruna Petcu, Janine Cooney, Christian Cook, Denis Lauren
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Patent number: 7220553Abstract: The invention relates to a method of monitoring the effect of a direct of indirect Factor Xa inhibitors comprising the steps of collecting a plasma sample from a patient, adding a solution of Russell's viper venom to the plasma sample and measuring the clotting time or the residual FXa activity chromogenically.Type: GrantFiled: April 18, 2002Date of Patent: May 22, 2007Assignee: Sanofi-Aventis Deutschland GmbHInventor: Valeria Fung-Hwei Chu
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Patent number: 7211222Abstract: A powder filler is stuffed in a filler space defined between a housing and a gas sensing element so as to airtightly seal a clearance between the housing and the gas sensing element. The powder filler contains grains whose diameter is in a range from 80 ?m to 5,000 ?m when measured before being stuffed into the filler space. A weight percentage of the grains having the diameter of 80 ?m to 5,000 ?m is equal to or larger than 80% with respect to an overall weight of the powder filler.Type: GrantFiled: July 24, 2002Date of Patent: May 1, 2007Assignee: Denso CorporationInventors: Motoaki Satou, Kiyomi Kobayashi, Masanobu Yamauchi, Namitsugu Fujii
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Patent number: 7189571Abstract: An analytical technique for the accurate and precise measurement of trace water in chemical reagents, comprising the steps of combining a chemical reagent comprising ?5 ppm water, with hexafluoroacetone (HFA), to form a sample mixture comprising at least the chemical reagent and a water derivative of hexafluoroacetone; and measuring the concentration of the water derivative of hexafluoroacetone by gas chromatography.Type: GrantFiled: March 27, 2002Date of Patent: March 13, 2007Assignee: Advanced Technology Materials, Inc.Inventors: Alexander S. Borovik, Ziyun Wang, Chongying Xu, Thomas H. Baum
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Patent number: 7166470Abstract: A combinatorial method for discovering or optimizing materials is disclosed. The method uses solution-based components that are mixed and dispensed into regions on a substrate for drying and/or heat-treating. The drying and/or heat-treating produces materials that can be tested for a desired property.Type: GrantFiled: January 3, 2003Date of Patent: January 23, 2007Assignee: Symyx Technologies, Inc.Inventors: Daniel M. Giaquinta, Martin Devenney, Keith A. Hall, Isy Goldwasser
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Patent number: 7150997Abstract: A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method, a value corresponding to a voltage is stored in a local memory associated with each electrode. The addressed electrodes are then driven at the voltages corresponding to the stored values. In another aspect of the method, a driving element associated with each addressed electrode is selectively coupled with a voltage line so as to charge the electrode with the voltage on the voltage line. The device and methods may be used in the synthesis of biopolymers such as oligonucleotides and peptides.Type: GrantFiled: March 15, 2005Date of Patent: December 19, 2006Assignee: Nanogen, Inc.Inventor: Gregory T. A. Kovacs
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Patent number: 7112448Abstract: A new method is proposed where a limited amount of MBTH is used to detect a point of interest (POI) of an aldehyde in a test sample. Preferably, it reacts with aldehyde first to form an azine. Only if there is remaining MBTH, it is oxidized to another species which combines with the azine to form formazan. However, if there is enough aldehyde, all the MBTH is converted to azine and there is no formation of blue color. Thus, by using the limiting agent MBTH to test the amount of aldehyde around the point of interest, then less aldehyde would produce more blue color and more aldehyde would produce less blue color. This method is especially useful in the quality control of aldehyde products. The end color may be different depending upon the order of addition of the reactants. For example, if an oxidizing agent and MBTH are mixed before adding the aldehyde, a light green to green/blue color results. This method could be used for solution test or for tests on a solid phase such as on nylon membrane.Type: GrantFiled: March 16, 2001Date of Patent: September 26, 2006Assignee: Ethicon, Inc.Inventors: Peter Zhu, Szu-Min Lin
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Patent number: 7112443Abstract: A library of material samples is screened for properties such as permeability. A library of material samples is provided. A stimulus such as an exposure to a permeate fluid is provided to each member of the library. A response of each of the material samples due to the stimulus is measured and the response, the stimulus or both are recorded and related to provide data. Thereafter, the data is analyzed to reach conclusions regarding the properties of the material samples.Type: GrantFiled: October 18, 2002Date of Patent: September 26, 2006Assignee: Symyx Technologies, Inc.Inventors: Damian A. Hajduk, Oleg Kolosov
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Patent number: 7101717Abstract: An addressable biologic electrode array includes an array of electrodes disposed on a support, the array of electrodes being selectively addressed and driven using a memory associated with each electrode of the array, the driven electrodes being driven at one of a plurality of stimulus levels by a source of electrical current or voltage external to the array.Type: GrantFiled: January 23, 2004Date of Patent: September 5, 2006Assignee: Nanogen, Inc.Inventor: Gregory T. A. Kovacs
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Patent number: 7090806Abstract: A portable, inexpensive, and easy to operate vehicle oxygen sensor analyzer shows, in real time, on an ultra-bright LED display, the dynamic operation of the oxygen sensor, simulates sensor signals into the computer, while monitoring the oxygen sensor to confirm correct computer operation, and performs a quick, simple and accurate test on the oxygen sensor to prove that it will pass emissions tests for oxygen sensors of the type typically required under emissions control regulations.Type: GrantFiled: April 30, 2001Date of Patent: August 15, 2006Inventor: Peter Lenehan
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Patent number: 7067323Abstract: A system and method for nondestructive automated headspace analysis. The system includes a container conveyor that conveys a plurality of generally optically transparent sealed test containers through a pre-inspection region, an inspection region and a post-inspection region of the container conveyor, and that conveys at least one sealed reference container, through the inspection region. Also included is a zone including a laser emitter and a sensor located in the inspection region and arranged such that the laser source emits a laser beam such that it intersects with a container movement path. The conveyor alternatingly conveys test containers and reference containers through the zone.Type: GrantFiled: October 15, 2003Date of Patent: June 27, 2006Assignee: Lighthouse Instruments, LLCInventors: James R. Veale, William R. Anderson, Warren M. Griffith, Glenn E. Edwards, George R. Howard
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Patent number: 7045097Abstract: A biologic electrode array is formed on a semiconductor substrate. A matrix of electrode sites is disposed on the semiconductor substrate. A matrix of optical detectors is disposed beneath the electrode sites in the semiconductor substrate, wherein each electrode site is associated with a corresponding optical detector. The optical detectors are coupled to detection circuitry formed on the semiconductor substrate. The electrode sites may include slitted electrodes, punctuated electrodes, or optically transparent electrodes.Type: GrantFiled: May 7, 2002Date of Patent: May 16, 2006Assignee: Nanogen, Inc.Inventor: Gregory T. A. Kovacs
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Patent number: 7026165Abstract: An apparatus and method for taking absorbance-based chemical measurements are described. In a specific embodiment, an indicator-based pCO2 (partial pressure of CO2) sensor displays sensor-to-sensor reproducibility and measurement stability. These qualities are achieved by: 1) renewing the sensing solution, 2) allowing the sensing solution to reach equilibrium with the analyte, and 3) calculating the response from a ratio of the indicator solution absorbances which are determined relative to a blank solution. Careful solution preparation, wavelength calibration, and stray light rejection also contribute to this calibration-free system. Three pCO2 sensors were calibrated and each had response curves which were essentially identical within the uncertainty of the calibration. Long-term laboratory and field studies showed the response had no drift over extended periods (months).Type: GrantFiled: January 31, 2001Date of Patent: April 11, 2006Assignee: The University of MontanaInventor: Michael D. DeGrandpre
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Patent number: 6967104Abstract: The present invention relates to a rapid method for estimation of Chemical Oxygen Demand (COD) of water, COD is an important parameter for determining the extent of pollution in water bodies, the basic principle of COD estimation is not much different from prior art but the time taken is reduced considerably and the results are equally sensitive and reproducible as other methods and the method used to generate data on the performance of effluent treatment plants in remote areas or rural areas, it also provide regular and sequential information on the quality of effluent generated by food processing industries.Type: GrantFiled: March 29, 2001Date of Patent: November 22, 2005Assignee: Council of Scientific and Industrial ResearchInventors: Vipin Chandra Kalia, Vikas Sonakya, Neena Raizada, Arvind Purshottam Joshi
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Patent number: 6958243Abstract: The present invention is drawn to a method of performing a one-pot organic reactions including carbon monoxide as reactant, without the use of an external CO gas source, wherein a reaction mixture containing a solid or liquid CO releasing compound, a non-metal substrate and a metal catalyst is exposed to an energy source to release carbon monoxide from the CO releasing compound and wherein carbon atoms of the released carbon monoxide form a bond with the non-metal substrate compound. The present invention is further drawn to a method of preparing chemical libraries and a kit for organic reactions.Type: GrantFiled: December 14, 2001Date of Patent: October 25, 2005Assignee: Biotage ABInventors: Mats Larhed, Mathias Alterman, Yiqian Wan, Hallberg Anders, Nils-Fredrik Kaiser
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Patent number: 6933151Abstract: A diagnostic system for monitoring catalyst performance in an exhaust system comprises a plurality of treatment devices catalytically treating an exhaust gas stream, and a plurality of gas sensors for monitoring the catalyst performance of the treatment devices to determine when sulfur poisoning occurs. An on-board diagnostic system receives signals from the gas sensors, and, based upon response time differentials between sensors, determines whether the treatment devices are experiencing sulfur poisoning.Type: GrantFiled: October 7, 2004Date of Patent: August 23, 2005Assignee: Delphi Technologies, Inc.Inventors: Owen H. Bailey, Jean J. Balland, Sergio Quelhas, Bart Schreurs
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Patent number: 6927066Abstract: A process is described, and also the system for its embodiment, for the determination of pollution by MTBE in the soil and in the overlying atmosphere. An example is described relating to the monitoring of underground fuel tanks for autotraction containing an oxygenated additive.Type: GrantFiled: February 18, 1999Date of Patent: August 9, 2005Assignee: Enitecnologie S.p.A.Inventor: Lucio De Angelis
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Patent number: 6913731Abstract: Intended for application on ducts through which flow a fluid at a high temperature, and particularly at a high pressure, comprising two bodies (4) and (8) which axially screw onto each other, one body (4) provided with a threaded neck (5) for attachment to the orifice of duct wall (3), which body (4) houses within it sensor element (2) of the probe which is thus placed inside the duct, with second body (8) screwed onto first body (4) and exerting on sensor element (2) the pressure required to secure it in its housing, with second body (8) further provided with an axial orifice through which passes a metallic tube (9) open to the exterior and which is provided with a metallic washer (10), soldered to said tube (9), which is separated from second body (8) by an electrically insulating washer (12).Type: GrantFiled: February 8, 2002Date of Patent: July 5, 2005Assignee: Union Fenosa Generacion, S.A.Inventors: José Manuel Bueno Harto, Francisco Javier Perosanz Lopez
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Patent number: 6881582Abstract: Disclosed is a method of making a bismuth molybdate precursor solution using a metallorganic decomposition (MOD) process consisting of the formation of a precursor sol of hexanoates of Bismuth (Bi) and Molybdenum (Mo). The precursor solution is used to make thin film of Bismuth molybdate by spin coating and spray pyrolysis. The bismuth molybdate films have the useful alpha and gamma phases having high sensitivity to ethanol gas, the detection of the ethanol gas is based upon the change of electrical conductivity of a thick film of the semiconductor oxide sensing element resulting from the ethanol gas in an oxygen-containing atmosphere. When the drying is effected by spray pyrolysis, quite thick films with high adhesion have been produced over different substrates, including quartz. The thin film of the present invention made by spray pyrolysis has a very fast response to ethanol detection eg typically 5 seconds.Type: GrantFiled: November 8, 2001Date of Patent: April 19, 2005Assignee: Council of Scientific and Industrial ResearchInventors: Alok Chandra Ratogi, Kiran Jain, Heremba Prasad Gupta, Vipin Kumar
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Patent number: 6867048Abstract: A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method, a value corresponding to a voltage is stored in a local memory associated with each electrode. The addressed electrodes are then driven at the voltages corresponding to the stored values. In another aspect of the method, a driving element associated with each addressed electrode is selectively coupled with a voltage line so as to charge the electrode with the voltage on the voltage line. The device and methods may be used in the synthesis of biopolymers such as oligonucleotides and peptides.Type: GrantFiled: May 7, 2002Date of Patent: March 15, 2005Assignee: Nanogen, Inc.Inventor: Gregory T. A. Kovacs
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Patent number: 6864094Abstract: The present invention provides a method for preserving an oxygen infusion containing an aqueous suspension of molecular assemblies which contain hemoglobin or a heme compound, by: a) modifying the molecular assemblies with polyoxyethylene; and b) converting the hemoglobin or the heme compound into a deoxy-form by removing oxygen from the suspension.Type: GrantFiled: March 7, 2002Date of Patent: March 8, 2005Assignee: Japan Science and Technology CorporationInventors: Eishun Tsuchida, Hiromi Sakai, Kenichi Tomiyama, Shinji Takeoka, Keitaro Sou
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Patent number: 6841387Abstract: The invention comprises novel apparatuses and testing methods for evaluating a fluid diffusion component. The apparatus includes a fluid capable of undergoing oxidation or reduction, a half-cell electrode assembly able to receive the fluid, and a change in acidity indicator in communication with the assembly. An inventive method of the invention includes the steps of passing a fluid capable of undergoing oxidation or reduction through a half-cell electrode assembly to form a sample, contacting the sample with an indicator, and detecting a change in acidity in the indicator.Type: GrantFiled: August 21, 2002Date of Patent: January 11, 2005Assignee: Advanced Energy Technology Inc.Inventor: David M. Kaschak
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Patent number: 6827903Abstract: A single pass analyzer includes multiple infrared sensors, a catalytic converter, a scrubber and a thermal conductivity cell all coupled in series to provide a single pass (i.e., one sample) analyzer which allows for fast analysis, allows for the speciation of hydrogen samples, requires no purging between different sample types, utilizes a single carrier gas, and eliminates molecular sieves and Shutze converters. The resultant analyzer provides improved quicker results with less plumbing (i.e., gas conduits and valving) in a single instrument.Type: GrantFiled: October 26, 2001Date of Patent: December 7, 2004Assignee: Leco CorporationInventor: Carlos Guerra
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Publication number: 20040235193Abstract: Methods, systems and kits for the simultaneous or sequential analysis of one or more hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal preparation time. The methods comprise ionizing the hormones and analyzing the hormones by mass spectrometry. In addition, methods, systems and kits for the simultaneous or sequential analysis of steroid hormones are disclosed comprising ionization of the steroid hormones by photoionization.Type: ApplicationFiled: April 14, 2004Publication date: November 25, 2004Inventor: Steven J. Soldin
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Patent number: 6812029Abstract: In order to prevent a catalyst for an internal combustion engine from decreasing efficiency by deterioration after long time use of the catalyst, the decreased efficiency of the catalyst is determined, and the internal engine is controlled based on results of the determination so as to maintain high efficiency of the catalyst. The catalyst is installed in an exhaust pipe of the engine. Sensors for detecting conditions of exhaust gas both at upstream side and downstream side of the catalyst are provided, respectively. As for the sensor, for example, an oxygen sensor of which output varies stepwise at &lgr;=1, or a sensor of which output varies in proportion to air-fuel ratio can be used. Detected values of the sensors are taken into a control unit, eliminating efficiency and deteriorating degree of the catalyst are estimated by comparison of the detected values, and the engine is controlled so that the eliminating efficiency becomes maximum.Type: GrantFiled: March 23, 2001Date of Patent: November 2, 2004Assignee: Hitachi, Ltd.Inventors: Minoru Ohsuga, Mamoru Fujieda, Nobuo Kurihara
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Patent number: 6811751Abstract: Method and apparatus for determining in a person's exhalation air the concentration of a specific substance in the blood by measuring the concentration of said substance and the concentration of water vapor in the exhalation air and utilizing a known relationship between these concentrations. When the method is applied the exhalation air is exhaled freely in a defined air volume having a predetermined composition, and said concentrations are measured in this air volume. The apparatus for working the method comprises a device (16) which defines a space for receiving the exhalation air, which has two mutually opposite openings through which the space communicates with the surrounding air, and means (18, 22, 23) for selective quantitative detection of said substance in the air in the defined space.Type: GrantFiled: April 11, 2002Date of Patent: November 2, 2004Assignee: Servotek ABInventors: Sven Gunnar Olsson, Stefan Brauer, Anders Linge, Tarmo Niininen, Krista Nilsson, Goran Rydgren
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Patent number: 6806091Abstract: The present invention relates to a method and apparatus for determining blood oxygen transport, and to measure lipid levels by correlating these levels with the rate at which oxygen diffuses through the red blood cell membrane.Type: GrantFiled: August 22, 2000Date of Patent: October 19, 2004Inventors: Henry Buchwald, Hector J. Menchaca, Van Michalek, Thomas J. O'Dea, Thomas D. Rohde
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Patent number: 6803236Abstract: A diagnostic system for monitoring catalyst performance in an exhaust system comprises a plurality of treatment devices catalytically treating an exhaust gas stream, and a plurality of gas sensors for monitoring the catalyst performance of the treatment devices to determine when sulfur poisoning occurs. An on-board diagnostic system receives signals from the gas sensors, and, based upon response time differentials between sensors, determines whether the treatment devices are experiencing sulfur poisoning.Type: GrantFiled: August 10, 2001Date of Patent: October 12, 2004Assignee: Delphi Technologies, Inc.Inventors: Owen H. Bailey, Jean J. Balland, Sergio Quelhas, Bart Schreurs
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Publication number: 20040170894Abstract: A positive electrode active material for use in a non-aqueous electrolyte secondary cell comprises a powdery metal oxide (LiCoO2, LiNiO2, LiMn2O4 or the like). When the positive electrode active material is classified with a classification precision index &kgr; of 0.7 or greater so as to obtain a coarse powder having a classification ratio in a range of 0.1% to 5%, a ratio (B/A) of the content (B) of an impurity metal element in the coarse powder obtained by the classification to the content (A) of the impurity metal element in the powder before the classification is 1.5 or less. The contents of the impurity metal elements are compared with respect to Ca, Mn, Fe, Cr, Cu, Zn and the like (exclusive of the metal element constituting the powdery metal oxide). The positive electrode active material for a secondary cell serves to improve cell performance capabilities and production yields.Type: ApplicationFiled: December 12, 2003Publication date: September 2, 2004Inventors: Ryo Sakai, Yasuhiro Shirakawa, Hajime Takeuchi, Yasumasa Ooya, Koshin Tanaka, Kazuki Amemiya, Shouta Endou
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Patent number: 6767715Abstract: A compound of the formula wherein X is Cl or CH3, or a salt thereof, is useful as a spin trap in various assays.Type: GrantFiled: December 11, 2001Date of Patent: July 27, 2004Assignee: Randox Laboratories Ltd.Inventors: Lynne Hamilton, Paul Graham Winyard
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Publication number: 20040142489Abstract: The invention relates to a method and apparatus for determining a concentration of a component in an unknown mixture. The method includes the steps of preparing a reactant having a specified pH level and a specified temperature and combining the unknown mixture with the reactant. The method further includes varying the pH level and temperature of the combination of the reactant and the unknown mixture to facilitate converting at least one selected component. Upon varying the pH level and temperature, the method will release volatiles from the selected component(s). Based on these released volatiles, which indicate the concentration of the selected component(s), the method detects the indication. The apparatus for determining a concentration of a component in an unknown mixture includes a container having a specified volume, a reactant chamber, and a sample chamber. The receptacle contains a reactant, placed within the reactant chamber, having a predetermined pH level and a predetermined volume.Type: ApplicationFiled: January 16, 2003Publication date: July 22, 2004Inventors: Otto J. Prohaska, Avinash Dalmia
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Publication number: 20040126891Abstract: A method of assaying the reactive oxidants present in a smoke sample, the method comprising: preparing solution including a reductant; passing smoke through the solution; detecting the concentration changes of the probe in the presence of the smoke sample over time; and calculating the concentration of reactive oxidants of the smoke sample from the concentration changes of the reductant in the presence of the smoke sample. A method of assaying the reactive oxidants present in a smoke sample, the method comprising: preparing a solid material containing a reductant; passing smoke through the solid material; detecting the concentration changes of the reductant in the presence of the smoke sample over time; and calculating the concentration of reactive oxidants of the smoke sample from the concentration changes of the reductant in the presence of the smoke sample.Type: ApplicationFiled: December 26, 2002Publication date: July 1, 2004Applicant: Brunswick LaboratoriesInventors: Dejian Huang, Boxin Ou
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Publication number: 20040106209Abstract: The present invention is directed to methods used to detect metabolic activity of biological samples based on their ability to consume oxygen.Type: ApplicationFiled: September 28, 2001Publication date: June 3, 2004Inventor: Steven C. Keith
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Patent number: 6719950Abstract: An exhaust gas sensor includes a housing and a sensor element supported by the housing. The sensor element includes a support member having an exhaust side, a reference side, and an aperture extending through the support member between the exhaust side and the reference side. The sensor element further includes an exhaust-side electrode on the exhaust side of the support member. The exhaust-side electrode is electrically connected to a contact on the reference side of the support member via a lead extending through the aperture. The aperture is sealed around the lead such that gas cannot pass through the aperture. The support member is oriented substantially parallel to the flow of exhaust gases when the exhaust gas sensor is installed on a vehicle. The sensor further includes a contact pin in the housing that engages the contact and biases the sensor element against a portion of the housing.Type: GrantFiled: November 14, 2001Date of Patent: April 13, 2004Assignee: Robert Bosch CorporationInventors: John Day, Jens Stefan Schneider, Harald Neumann, Heinrich Hipp
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Patent number: 6720171Abstract: A process for preparing arrays of two or more heterogeneous catalysts, heterogeneous catalyst precursors, or combinations thereof in a body having preferably parallel through-channels. In this process, a solution, emulsion or dispersion of elements present in the catalyst, catalyst precursor, or combination thereof, is first prepared, and is used to simultaneously or successively coat the channels of the body to produce freshly impregnated moist channels. These channels are then treated and reacted with one or more reactive gases, and the coated body is optionally heated in the presence or absence of inert or reactive gases.Type: GrantFiled: December 12, 2000Date of Patent: April 13, 2004Assignee: BASF AktiengesellschaftInventors: Stephan Andreas Schunk, Dirk Demuth, Hartmut Hibst
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Patent number: 6703245Abstract: The oxygen detecting composition of the present invention includes a layered silicate, a cationic surfactant, an organic colorant, a reducing agent, and optionally a basic substance. The oxygen detecting composition is suitable for indicating the presence or absence of oxygen or the degree of oxygen concentration by its reversible color change because of its high light resistance, high heat resistance, transparency and translucency.Type: GrantFiled: October 23, 2002Date of Patent: March 9, 2004Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Makoto Sumitani, Haruo Inoue, Ken Sugito
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Publication number: 20040043498Abstract: Compounds useful as agents for measurement of singlet oxygen, which are represented by the following general formula (I): 1Type: ApplicationFiled: August 27, 2003Publication date: March 4, 2004Inventors: Tetsuo Nagano, Yasuteru Urano, Kumi Tanaka
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Patent number: 6692970Abstract: A method and apparatus are provided for measuring the gas efflux from a substrate. In particular, one or more measuring chambers receive a gas enriched air from the substrate. A respiration system sends reference air having a known gas concentration to the measuring chamber. The reference air mixes with the gas enriched air to form a mixed air, which is returned to the respiration system. The respiration system then measures the gas efflux of the substrate over the given amount of time.Type: GrantFiled: January 5, 2001Date of Patent: February 17, 2004Assignee: The United States of America as represented by the Secretary of AgricultureInventors: John R. Butnor, Christopher A. Maier, Kurt H. Johnsen
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Publication number: 20040029294Abstract: A method for determining the origin of substances with biological, biochemical and nutritional physiological relevance and distinguishing them from synthetic analogs using their relative positional oxygen or hydrogen isotope ratios (&dgr;18O value and &dgr;2H value), in which—based on the fact that for organic compounds there are at least two different primary or secondary sources for these elements, each with different isotope values, and the incorporation of these elements is accompanied by different, but characteristic effects—the positional &dgr;18O values or &dgr;2H values are individually determined in the substances to be tested and they are compared with the values expected from biosynthesis, where a correspondence or deviation allows the authenticity or origin or adulteration of the substance to be detected.Type: ApplicationFiled: June 10, 2003Publication date: February 12, 2004Inventors: Hanns-Ludwig Schmidt, Claudio Fuganti
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Patent number: 6682936Abstract: A biologic electrode array assembly is formed on an integrated circuit chip that includes an array of electrodes. At least one metal oxide semiconductor (MOS) switch is coupled to at least one of the electrodes within the array. A voltage line is provided that is selectively connected to the at least one electrode via the MOS switch. A voltage source is coupled to the voltage line. In one preferred aspect of the invention, the MOS switch is a CMOS switch. In another aspect of the invention, an addressable memory is associated with the at least one electrode located within the array.Type: GrantFiled: July 10, 2001Date of Patent: January 27, 2004Assignee: Nanogen, Inc.Inventor: Gregory T. A. Kovacs
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Publication number: 20030236591Abstract: A process and system for purifying an impure gas to produce a purified gas in a gas purification system and protecting the system from damage by a) passing a portion of a first gas stream into a reactor vessel, which exits as a second purified gas stream; b) combining a portion of the second purified gas stream with another portion of the first gas stream to form a combined gas stream; and c) passing the combined gas stream into a sensing device to regulate the flow of the first and second gas streams into the reactor vessel.Type: ApplicationFiled: June 20, 2002Publication date: December 25, 2003Inventors: John Fredric Billingham, Jerry Michael Mahl
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Patent number: 6660231Abstract: The mixed oxide WxMo1-xO3, where preferably x can be in the range 0.01 to 0.9, is very useful for the detection of oxidizing gases and in particular is superior for the detection of ozone. The preferred composition is in the range of 1% to 21% Mo (i.e. 99% to 79% W). The present example in which the composition of the sensing material is in the range WxMo1-xO3 with x varying from 0.01 to 0.9, is clearly distinct from the device claimed in applicant's earlier patent. Precipitation of the material as a mixed oxide from an aqueous solution of the ammonium metallates in concentrations of the appropriate stoichiometric proportions yields a powder that can be screen-printed to give an ideal microstructure. Resistivity of the material may be tailored to a desired value by adjusting the Mo/W ratio within the single phase field. Varying this ratio adjusts catalytic properties of the material.Type: GrantFiled: April 13, 2001Date of Patent: December 9, 2003Assignee: Atmospheric Sensors, LLCInventor: Patrick T. Moseley
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Publication number: 20030219907Abstract: An apparatus for notifying a user which gas tank(s) to connect to an enclosed chamber such as an incubator. The user inputs the desired setpoints for gasses such as O2 and CO2, and the corresponding gas level is determined. The determined gas level is compared with the setpoint of the gas and can display, which gas tank(s) should be hooked up to chamber.Type: ApplicationFiled: May 22, 2002Publication date: November 27, 2003Applicant: Kendro Laboratory Products, Inc.Inventors: Richard H. Bair, Bryan M. Elwood
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Patent number: 6645772Abstract: A method for detecting the presence and amount of carbon monoxide, comprising the use of infrared spectroscopy to compare the spectra of the test gas containing carbon monoxide and the reference gas. The reference gas is the test gas from which carbon monoxide had been removed by conversion using catalysts. The presence and quantity of carbon monoxide is determined by deducting the spectrum of the reference gas from the spectrum of the test gas. The catalysts comprise nanoparticles of gold precipitated on a metal oxide or hydroxide carrier. An apparatus implementing this method.Type: GrantFiled: October 18, 2000Date of Patent: November 11, 2003Assignee: HRL Laboratories, LLCInventors: Kevin W. Kirby, Amanda C. Phelps, Robert N. Schwartz
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Patent number: 6638711Abstract: The invention relates to methods for identifying candidate pharmacological agents to be used in the treatment and/or prevention of Alzheimer's disease and/or related pathological conditions.Type: GrantFiled: April 28, 2000Date of Patent: October 28, 2003Assignee: The General Hospital CorporationInventors: Ashley I. Bush, Xudong Huang, Craig S. Atwood, Rudolph E. Tanzi
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Publication number: 20030194351Abstract: A galvanic measuring device for detecting oxygen content in a gas flow, having a sealed gas flow chamber and a layer of sodium chloride saturated sponge material lining the interior of the gas flow chamber, for providing a constant source of humidity to the chamber.Type: ApplicationFiled: April 15, 2002Publication date: October 16, 2003Inventor: Stephen D. Tuomela
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Patent number: 6627443Abstract: The present invention relates to new color compositions which are especially suitable to be used in oxygen indicators. The compositions comprise iron(II), an agent containing pyrogallol entities and an organic acid.Type: GrantFiled: April 27, 2000Date of Patent: September 30, 2003Assignee: Fresenius Kabi ABInventors: Åke Stenholm, Lars Karlsson, Anders Löfgren, Bo Nystrom, Otto Skolling
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Patent number: 6623975Abstract: A method and system for vehicle emission testing measures pollutant concentration, but then provides for conversion of the measured pollutant concentration into its corresponding pollutant mass, thereby allowing for the calculation of a vehicle's emission test scores for one or more common pollutants in units of mass per distance. Through the use of the method and system of the present invention, significantly more accurate results can be obtained as compared to prior art test methods, and without the implementation, operating, and maintenance costs of comparable test methods.Type: GrantFiled: May 8, 2001Date of Patent: September 23, 2003Assignee: Gordon-Darby Systems, Inc.Inventors: Robert J. Tefft, S. Jay Gordon, Clifton Mahaffey
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Patent number: 6623699Abstract: An analyzer compensates for gas flow perturbations by providing a makeup flow of carrier gas to maintain the pressure and/or flow rate of analyte and inert gas through a detector constant such that a accurate determination of a low concentration of an analyte in the presence of a high concentration of a second analyte can be accurately determined. In one embodiment, a carrier gas is introduced through a valve responsive to the detected pressure in the gas flow stream between a scrubber and a subsequent detector for maintaining the pressure constant during an analysis. In another embodiment of the invention, a flow transducer is positioned in the gas flow path between the scrubber and detector and coupled to a flow control valve coupled to introduce carrier gas as a function of detected gas flow such that the flow rate of gas into the detector is maintained constant.Type: GrantFiled: November 15, 2000Date of Patent: September 23, 2003Assignee: Leco CorporationInventors: Brian W. Pack, Carlos Guerra, Peter M. Willis, Joel C. Mitchell
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Publication number: 20030148533Abstract: The present invention provides a combination of carbon-13 and deuterium metabolic tracers and methods that when used in conjuction with nuclear manegtic resonance spectroscopy, provide a measurement of metabolic fluxes in the target organisms. The tracers of the present invention may be taken orally during the same clinical exam. The metabolic information can be derived from blood, urine or other fluids to provide a comprehensive profile of glucogenic metabolism. The subject matter of the present invention may be applied to the study of metabolic dysfunction related to obesity, diabetes, HIV infection and a variety of other disease conditions.Type: ApplicationFiled: May 1, 2001Publication date: August 7, 2003Inventors: Craig R. Malloy, A. Dean Sherry, John G. Jones