Oxygen Containing Patents (Class 436/127)
-
Publication number: 20030092189Abstract: A test method and device are described for quantitatively determining the presence and concentration of chlorine dioxide in aqueous solution, which may contain chlorine. Contacting the aqueous solution containing chlorine dioxide with a test strip in accordance with the invention produces a color change in proportion to the concentration of the chlorine dioxide. The invention has particular utility in determining the presence of chlorine dioxide in water containing chlorine such as municipal water.Type: ApplicationFiled: October 16, 2001Publication date: May 15, 2003Inventors: Lydia K. Johnson, Vinay D. Ghanekar
-
Patent number: 6564155Abstract: A method and an apparatus tests liquids. When the method is implemented, following a reaction of constituents in the liquid with the maximum quantity at least of one free oxidizing agent and/or reagent contained in the liquid, the quantity of oxidizing agent and/or reagent remaining in the liquid is displayed visually as a measure of the quantity of constituents in the liquid reacting with the oxidizing agent and/or reagent. For implementing the method, use is made of a sensor that is configured as a sheet-like structural element and is provided with at least one inlet opening, a sample-accommodating channel, a mechanical pump, a transporting capillary, a detection zone, an emptying channel, and an outlet opening.Type: GrantFiled: July 23, 2001Date of Patent: May 13, 2003Assignee: ABB Patent GmbHInventors: Albrecht Vogel, Dieter Binz, Peter Krippner, Sean Keeping
-
Publication number: 20030082816Abstract: A single pass analyzer includes multiple infrared sensors, a catalytic converter, a scrubber and a thermal conductivity cell all coupled in series to provide a single pass (i.e., one sample) analyzer which allows for fast analysis, allows for the speciation of hydrogen samples, requires no purging between different sample types, utilizes a single carrier gas, and eliminates molecular sieves and Shutze converters. The resultant analyzer provides improved quicker results with less plumbing (i.e., gas conduits and valving) in a single instrument.Type: ApplicationFiled: October 26, 2001Publication date: May 1, 2003Inventor: Carlos Guerra
-
Publication number: 20030082822Abstract: A method and system for determining a concentration level of NOx in an exhaust stream from a combustion source. The method comprises capturing sample gas from the exhaust stream using a sampling device. NO2 in the sample gas is converted to NO by passing the sample gas through a catalytic NO2 converter. The method also comprises removing water from the sample gas by passing the sample gas through a dryer and determining a sample gas NO concentration level. The step of converting NO2 is performed at a temperature above the dew point temperature of the sample gas.Type: ApplicationFiled: March 6, 2002Publication date: May 1, 2003Inventors: William Steven Lanier, Glenn England
-
Patent number: 6511850Abstract: A self-adjusting, free-flowing pneumatic nebulizer interface is described for coupling fluid phase separation apparatus such as capillary electrophoresis apparatus or fluid-phase analyte delivery apparatus such as flow-injection analysis apparatus to gas phase, post-separation detection apparatus such as mass spectrometers, chemiluminescence detectors, or other similar gas phase detection apparatus. The interface combines the analytes with only the needed amount of sheath fluid to produce a combined flow whose magnitude automatically matches the self-aspiration rate of the pneumatic nebulizer interface, and which is combined with a gas flow to produce an aerosol. The resulting aerosol can then be either deposited directly on a surface, forwarded directly to a detection system or forwarded first to a conversion apparatus such as an oxidizer and the oxidized sample components are then forwarded to a detector.Type: GrantFiled: July 12, 2000Date of Patent: January 28, 2003Assignee: The Texas A&M University SystemInventors: Gyula Vigh, Alex D. Sokolowski
-
Publication number: 20030017603Abstract: An upstream side catalyst and a downstream side catalyst are disposed in an exhaust passage. A first oxygen sensor is disposed between these two catalysts and a second oxygen sensor is disposed downstream of the downstream side catalyst. The air-fuel ratio is forcibly oscillated and the oxygen storage capacity of the upstream side catalyst is detected. Deterioration of the upstream side catalyst is then detected based on whether this oxygen storage capacity is larger than a predetermined value. The forced oscillation of the air-fuel ratio is performed only when the oxygen storage state of the downstream side catalyst is appropriate.Type: ApplicationFiled: July 15, 2002Publication date: January 23, 2003Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Takahiro Uchida, Hiroshi Sawada, Toshinari Nagai, Akihiro Katayama, Yasuhiro Kuze, Naoto Kato
-
Patent number: 6495370Abstract: This invention relates to novel haloenol lactone compounds. These compounds have the following general structure: in which Ar is an aryl group and Y is a haloenol lactone moiety. The compounds of the invention are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. Measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The compounds of the invention are also useful for treatment of drug resistance in cancer and for preventing herbicide resistance in plants.Type: GrantFiled: August 15, 2000Date of Patent: December 17, 2002Assignee: The Regents of the University of CaliforniaInventors: A. Daniel Jones, Alyson E. Mitchell, Bruce D. Hammock, Jiang Zheng
-
Patent number: 6468657Abstract: Multilayered porous materials are formed by coating a porous substrate with a metal and adsorbing an organic layer comprising a recognition moiety onto the metal film. The recognition moiety interacts with an analyte of interest allowing for its detection, purification, etc. Suitable recognition moieties can be selected from a range of species including, small molecules, polymers and biomolecules and the like. The novel porous materials of the invention can be utilized in an array of methods including, ion-exchange, ion-selective ion-exchange, assays, affinity dialysis, size exclusion dialysis and the like.Type: GrantFiled: December 4, 1998Date of Patent: October 22, 2002Assignee: The Regents of the University of CaliforniaInventors: Zhizhong Hou, Pieter Stroeve, Nicholas Abbott
-
Publication number: 20020150507Abstract: The measuring sensor, particularly a lambda probe, has a ceramic sensor member retained at a high temperature during measuring operation. It is shielded from water droplets, carried along in the gas to be analyzed, by a heated protective housing, permeable for the gas to be analyzed, by which water droplets carried along in the direction of the sensor member are evaporated before reaching the sensor member. In this way, the water droplets are unable to cause any shock-like temperature drops at spots on the surface of the sensor member or material flaking.Type: ApplicationFiled: October 19, 2001Publication date: October 17, 2002Inventors: Helmut Weyl, Hans-Martin Wiedenmann
-
Publication number: 20020152036Abstract: This invention is directed to a method and apparatus for controlling and optimizing the feed of two or more oxidizers to an aqueous stream, thereby providing a synergistic effect. The system combines the use of amperometric or ORP based sensor technology with amperometric sensor technology employing a gas permeable membrane, thereby providing definitive control of each oxidizer feed stream.Type: ApplicationFiled: February 9, 2001Publication date: October 17, 2002Inventor: Roy Martin
-
Publication number: 20020137221Abstract: There is provided a method for preserving an oxygen infusion comprising a suspension containing hemoglobin or a heme derivative contained in molecular assemblies suspended in a aqueous medium, comprising modifying the molecular assemblies with polyoxyethylene, and making the hemoglobin or the heme derivative to a deoxy-type by removing oxygen from the suspension.Type: ApplicationFiled: March 7, 2002Publication date: September 26, 2002Applicant: Japan Science and Technology CorporationInventors: Eishun Tsuchida, Hiromi Sakai, Kenichi Tomiyama, Shinji Takeoka, Keitaro Sou
-
Publication number: 20020132359Abstract: A means for dispensing a single unit dose of an oxygen-sensitive drug without exposing the remaining unit dosages to oxygen is described herein. Each unit dose is individually encapsulated in the pharmaceutical packaging construction such that when one unit dose is dispensed the other unit doses remain encapsulated. An oxygen-absorber is also incorporated into the construction such that the oxygen absorber has sufficient contact with the air surrounding the oxygen-sensitive drug to remove at least a portion of the oxygen in the air to reduce or eliminate undesirable oxidative degradation of the drug in its encapsulated environment.Type: ApplicationFiled: March 15, 2002Publication date: September 19, 2002Inventor: Kenneth C. Waterman
-
Publication number: 20020132352Abstract: In order to prevent a catalyst for an internal combustion engine from decreasing efficiency by deterioration after long time use of the catalyst, the decreased efficiency of the catalyst is determined, and the internal engine is controlled based on results of the determination so as to maintain high efficiency of the catalyst. The catalyst is installed in an exhaust pipe of the engine. Sensors for detecting conditions of exhaust gas both at upstream side and downstream side of the catalyst are provided, respectively. As for the sensor, for example, an oxygen sensor of which output varies stepwise at &lgr;=1, or a sensor of which output varies in proportion to air-fuel ratio can be used. Detected values of the sensors are taken into a control unit, eliminating efficiency and deteriorating degree of the catalyst are estimated by comparison of the detected values, and the engine is controlled so that the eliminating efficiency becomes maximum.Type: ApplicationFiled: May 23, 2002Publication date: September 19, 2002Applicant: Hitachi, Ltd.Inventors: Minoru Ohsuga, Mamoru Fujieda, Nobuo Kurihara
-
Patent number: 6436347Abstract: A fast-response colorimetric carbon dioxide indicator device which is substantially insensitive to humidity and comprises a chemically inert substrate and an indicator composition supported by the substrate and responsive to exposure to carbon dioxide in expired respiratory air to undergo a color changing reaction. The indicator composition includes a pH sensitive dye and a basic substance having the general formula in which X is a nitrogen or phosphorus atom, each of R1, R2, R3 and R4 is an alkyl, Y− is an anion selected from the group consisting of hydroxide, fluoride, chloride, bromide, iodide, carbonate, and tetrafluoroborate, at least one of the alkyls R1, R2, R3 and R4 having at least 13 carbon atoms and at least one of the other alkyls having from 6 to 8 carbon atoms, the remaining alkyls, if any, having from 1 to 12 carbon atoms.Type: GrantFiled: May 30, 2000Date of Patent: August 20, 2002Assignee: Mincor ABInventor: Andras Cedeon
-
Patent number: 6432718Abstract: In order to quickly and economically evaluate cleanliness of a metal with high representativity when quantities, compositions, etc., of non-metallic inclusion particles existing in a metal and resulting in product defects are evaluated by a sample collected during the production process of the metal, the present invention provides an evaluation method involving the steps of levitation-melting a metal piece for a predetermined time by cold crucible levitation-melting means, discharging non-metallic inclusion particles contained in the metal piece to the surface of a molten metal, and directly analyzing a curved and non-smooth sample surface after solidification by dissolving the surface and extracting and filtering the inclusions to measure or analyze the quantities of elements constituting the non-metallic inclusion particles and to determine quantity of the non-metallic inclusions.Type: GrantFiled: September 22, 1999Date of Patent: August 13, 2002Assignee: Nippon Steel CorporationInventors: Kazushige Umezawa, Tokio Suzuki, Koichi Chiba, Ryuji Uemori, Takehiko Toh, Hiroyuki Kondo, Katsuhiro Fuchigami, Eiichi Takeuchi, Masamitsu Wakoh, Akihiro Ono
-
Patent number: 6429021Abstract: The present invention provides an assay for detecting the presence of an array or a profile of antioxidant activity in any sources or products. In particular, the invention provides a method in which a sample is extracted with a polar, a non-polar and a semi-polar solvent to obtain three extracts; the extracts are chromatographed to get a chemical profile; and the profile is analyzed to determine the presence of antioxidants by directly reacting to a free-radical.Type: GrantFiled: March 19, 1998Date of Patent: August 6, 2002Assignee: Amway CorporationInventors: Yong Qian, Richard E. A. Leitz, David W. Krempin
-
Patent number: 6416737Abstract: The present invention is a method and composition to increase bone strength in a manner that decreases fracture incidence, which may or may not include increasing bone mineral density (“BMD”). The invention includes administering an effective amount of a bisphosphonate to a host in need thereof to increase bone strength, which inhibits the apoptosis of osteoblasts and osteocytes, without a significant effect on osteoclasts. In one embodiment, the bisphosphonate is not 1-amino-3-(N,N-dimethylamino)-propyliden-1,1-bisphosphonic acid or its pharmaceutically acceptable salt. An increase in osteoblast life span can lead to an increase in bone mass, i.e., an anabolic effect. Preservation of osteocyte life span can increase bone strength, which may be disproportional to the increase in bone mass.Type: GrantFiled: November 19, 1999Date of Patent: July 9, 2002Assignee: Board of Trustees of the University of ArkansasInventors: Stavros C. Manolagas, Teresita Bellido
-
Patent number: 6399387Abstract: The present invention relates to new color compositions which are especially suitable to be used in oxygen indicators. The compositions comprise iron(II), an agent containing pyrogallol entities and an organic acid.Type: GrantFiled: January 22, 1999Date of Patent: June 4, 2002Assignee: Pharmacia ABInventors: Åke Stenholm, Lars Karlsson, Anders Löfgren, Bo Nyström, Otto Skolling
-
Patent number: 6391646Abstract: An electron paramagnetic resonance spectroscopic method for quantifying molecular oxygen and its isotopes in a sample and an electron paramagnetic resonance spectrometric cell for use in this method are provided.Type: GrantFiled: January 29, 1999Date of Patent: May 21, 2002Inventor: Sergi V. Khangulov
-
Patent number: 6387706Abstract: A method and apparatus for measuring vehicle exhaust emission includes sampling vehicle exhaust and a dilute mixture of vehicle exhaust and ambient air. A first analyzer measures concentrations of gas components of undiluted vehicle exhaust. A second analyzer measures concentration or temperature of at least one exhaust gas component present in the dilute mixture gas component. Flow rate of the dilute mixture, the concentration and/or temperature of the at least one dilute mixture gas component and undiluted gas concentration are analyzed by a microprocessor to produce mass emissions of the vehicle exhaust gas components.Type: GrantFiled: April 13, 2000Date of Patent: May 14, 2002Assignee: Sensors, Inc.Inventor: Gideon Eden
-
Patent number: 6368867Abstract: The present invention provides an ozone processing monitor and a method of using the same in ozone processing to determine whether sufficient ozone treatment has occurred on a production part needing ozone treatment. The ozone processing monitor of the present invention comprises an ozone sensitive material which is capable of thinning, bleaching, forming an oxide layer or undergoing any other physical or chemical change upon exposure to ozone, wherein said physical or chemical change produces a visible color change of said ozone sensitive material which can be monitored during or following ozone processing. The color change of the ozone sensitive material can be compared to standards to determine if too little, too much or appropriate ozone treatment has occurred.Type: GrantFiled: January 29, 1998Date of Patent: April 9, 2002Assignee: International Business Machines CorporationInventors: Margaret Lecko Gibson, John James Lajza, Jr., Harold George Linde
-
Patent number: 6329208Abstract: Simple equations that relate glucose, glutamate, glucuronate, and phenylacetylglutamine 13C NMR multiplet areas to gluconeogenesis and pyruvate recycling during metabolism of [1,2,3-13C3]propionate are presented. This indicates that a direct measure of gluconeogenesis, pyruvate recycling, and anaplerosis may be obtained from a single 13C NMR spectrum of suitably prepared blood or urine samples collected after oral administration of enriched propionate, acetaminophen, and phenylacetate.Type: GrantFiled: July 16, 1998Date of Patent: December 11, 2001Assignee: Board of Regents, The University of Texas SystemInventors: John G. Jones, A. Dean Sherry, F. M. H. Jeffrey, G. Larry Cottam, Craig. R. Malloy
-
Patent number: 6323038Abstract: In view of the situation of the prior art, the present invention specifies the structure of a late-stage product of Mailard reaction in vivo having a close relation with various tissue disorders, and provides a diagnostic reagent for complications associated with diabetes or renal failure, containing the above compound as a main component.Type: GrantFiled: January 14, 2000Date of Patent: November 27, 2001Assignee: Asai Germanium Research Institute Co., Ltd.Inventors: Tomoko Oya, Hiroyuki Kobayashi, Mitsuo Akiba, Norihiro Kakimoto, Yasujiro Morimitsu, Toshihiko Osawa
-
Patent number: 6316269Abstract: The present invention provides screening methods for identifying compounds which induce tardive dyskinesia (TD) when administered to an animal. In particular, the methods involve assaying for intermediates and end products of reactions associated with candidate compound mediated reduction of reducible substrates. Also provided are high-throughput screening methods for determining whether compounds induce TD when administered to an animal. Further, provided are methods for treating psychoses comprising testing antipsychotic drugs to identify those which will not induce TD when administered to an animal and administering one or more such drugs to a patient in need thereof.Type: GrantFiled: October 6, 1998Date of Patent: November 13, 2001Assignee: The General Hospital CorporationInventors: Guochuan Tsai, Xudong Huang, Ashley I. Bush
-
Patent number: 6306661Abstract: The oxygen concentration of a sample is determined utilizing a water-soluble metal ligand complex which is brought into interactive proximity with the sample to form a mixture. The mixture is irradiated with electromagnetic light energy so as to cause emission of light indicative of oxygen. The emitted light is measured, and the measurement utilized so as to determine oxygen concentration of the sample.Type: GrantFiled: February 5, 1998Date of Patent: October 23, 2001Inventors: Joseph R. Lakowicz, Felix Castellano
-
Patent number: 6284545Abstract: A filter for reducing the cross-sensitivity of a chlorine dioxide detector to hydrogen sulfide. The filter includes a high surface area substrate impregnated with a silver (I) salt or copper (II) salt which is effective to remove hydrogen sulfide from a gas stream without producing undesirable compounds which might be detected by the sensor. The preferred compounds are copper chloride (CuCl2), copper bromide (CuBr2), silver acetate (AgO2CCH3), silver bromate (AgBrO3), silver bromide (AgBr), silver carbonate (Ag2CO3), silver chloride (AgCl), silver chromate (Ag2CrO4), silver cyanide (AgCN), silver iodate (AgIO3), silver oxide (Ag2O), silver perchlorate (AgClO4), silver permanganate (AgMnO4), silver sulfate (Ag2SO4), silver hexafluorophosphate (AgPF6), silver fluoride (AgF), silver tetrafluoroborate (AgBF4), silver iodide (AgI) and silver trifluoromethane sulfonate (AgO3SCF3).Type: GrantFiled: March 24, 1999Date of Patent: September 4, 2001Assignee: Industrial Scientific CorporationInventors: P. Richard Warburton, Ronald Scott Sawtelle
-
Patent number: 6258606Abstract: An improved biologic electrode array and methods for manufacturing and using the same. In one aspect, a matrix of electrodes each coupled to a respective sample-and-hold circuit is provided. The electrodes and sample-and-hold circuits are integral and form an array within a single semiconductor chip, such that each sample-and-hold circuit may be loaded with a predefined voltage provided by a single, time-shared digital-to-analog converter (DAC). Further, all of the sample-and-hold circuits may be accessed through a multiplexer which may be scanned through some or all of the electrode locations. Each sample-and-hold circuit may comprise a capacitor and one or more transistor switches, the switch(es), when closed, providing electrical communication between the capacitor and a source line formed in the matrix.Type: GrantFiled: July 30, 1999Date of Patent: July 10, 2001Assignee: Nanogen, Inc.Inventor: Gregory T. A. Kovacs
-
Patent number: 6254829Abstract: There is disclosed an optical sensor including a matrix containing a luminescence indicator whose luminescence may be quenched by oxygen. The optical sensor contains at least one agent capable of deactivating singlet oxygen and has an enhanced stability relative to oxygen.Type: GrantFiled: September 28, 1998Date of Patent: July 3, 2001Assignee: AVL Medical InstrumentsInventors: Paul Hartmann, Marco Jean Pierre Leiner
-
Patent number: 6207461Abstract: Compounds of formula (I) wherein Me is Pd(II) or Pt(II); R is H or C1-C18 alkyl, or is C3-C8 cycloalkyl, phenyl, pyridyl or phenyl-C1-C4 alkylene, each of which is unsubstituted or substituted by C1-C18 alkyl, C1-C18 alkoxy, R3—O—C(O)—, halogen, —CN or by —NO2; R1 and R2 are each independently of the other H, C1-C12 alkyl or C1-C12 alkoxy or R1 and R2 together are —OCH2O—, —OCH2CH2O—, or —CH═CH—CH═CH—, and R3 is C1-C18 alkyl, C3-C18 cycloalkyl, phenyl, benzyl, C1-C12 alkylphenyl or C1-C12 alkylbenzyl. Compounds of formula (I) are valuable luminophores and/or intermediates for the preparation of palladium (II) or platinum (II) benzoporphyrins, which are likewise luminophores.Type: GrantFiled: January 21, 1999Date of Patent: March 27, 2001Assignee: Novartis AGInventors: Marcus Baumann, Adrian Waldner
-
Patent number: 6180412Abstract: An improved test is described for chlorine in pool and spa water where potassium monopersulfate is used as an oxidizing agent and DPD is used as an indicator. N,N-bis(hydroxyethyl)-2-aminoethane sulfonic acid or bicine is used to mask or eliminate the potassium monopersulfate so that it does not interfere with the DPD indicator. The test is very reliable and accurate.Type: GrantFiled: March 26, 1999Date of Patent: January 30, 2001Assignee: Hach CompanyInventor: Dan J. Kroll
-
Patent number: 6171867Abstract: The invention relates to a sensor comprising a piezoelectric crystal with a polyarylene thioether-containing coating, the coating containing at least one polyarylene system having repeating units of the formula I, —[(Ar1)n—X]m—[(Ar2)i—Y]j—[(Ar3)k—Z]l—[(Ar4)o—W]p— (I) which contain at least one thioether group, in which Ar1, Ar2, Ar3 and Ar4 are identical or different aryl systems having from 6 to 18 carbon atoms, W, X, Y and Z are identical or different linking groups, selected from the group comprising —SO2—, —S—, —SO—, —O—, —CO—, —CO2—, alkylene or alkylidene having from 1 to 6 carbon atoms and —NR1—, where R1 is an alkyl or alkylide group having from 1 to 6 carbon atoms and at least one linking group must be —S—, n, m, i, j, k, l, o, p are, equal or different, integers zero, 1, 2, 3 or 4, their sum havinType: GrantFiled: January 26, 1995Date of Patent: January 9, 2001Assignee: Ticona GmbHInventors: Gernot Feucht, Andreas Schleicher, Georg Frank
-
Patent number: 6146896Abstract: A method and apparatus for determining nitrification effectiveness of activated sludge in an aqueous solution, includes supplying equivalent quantities of an activated sludge, an aqueous solution, and a gas containing oxygen to each of first and second reaction vessels; simultaneously delivering a nitrification inhibitor to only the second reaction vessel; performing a bacterial respiration reaction in the vessels for either a preselected period of time or continuously in which case the materials are supplied per unit of time so that the bacterial respiration reaction in the first reaction vessel, where oxygen consumption as a result of total bacterial respiration occurs and includes oxygen consumption as a result of endogenous respiration, oxygen consumption as a result of nitrification, and oxygen consumption as a result of degradation of carbon compounds, may be compared with the respiration reaction in the second reaction vessel where oxygen consumption includes oxygen consumption as a result of endogenouType: GrantFiled: September 19, 1997Date of Patent: November 14, 2000Assignee: LAR Analytik und Umweltmesstechnik GmbHInventor: Ulrich Pilz
-
Patent number: 6143571Abstract: The method for analyzing a metal for oxygen, using inert gas carrying fusion/infrared absorption analysis, having the steps of: placing a metal analyte in a graphite crucible; heat-melting the metal analyte; extracting a gas from the melt bath; and analyzing the gas to determine the total oxygen content of the metal in the form of a plurality of separated waves, wherein the metal analyte is heated at a temperature rise rate of not more than 20.degree. C./sec in a period from a starting point A of a first wave to a peak point B of the first wave, held at a constant temperature in a period from the peak point B of the first wave to an end point C of the first wave, and, after the completion of the appearance of the first wave, is heated to melt the metal analyte for further analysis.Type: GrantFiled: July 10, 1998Date of Patent: November 7, 2000Assignee: Sanyo Special Steel Co., Ltd.Inventors: Yoshio Nuri, Tomoko Ise, Yoshiyuki Kato
-
Patent number: 6117686Abstract: The present invention provides a method by which harmful trace gases in a gaseous mixture containing as such harmful halogen gases, halogenated hydrogen gases, acid gases, oxidizing gases, basic gases, organic acid gases, especially halogen gases or halogenated hydrogen gases, are detected by using tetraphenylporphyrin (TPP) and quantitated from a calibration curve constructed therefrom, where the range of detectable concentration is made adjustable so that harmful gas can be detected and quantitated over a broad range of concentration. Furthermore, this invention also provides a method for extending the accessible range of gas concentration by adjusting the sensitivity of the detector material via control of tetraphenylporphyrin concentration in matrix polymer of the detector material, by controlling the gas concentration range via measurement at a specific wavelength(s), and by the use of a plurality of detector materials with pre-set assay sensitivity.Type: GrantFiled: August 3, 1999Date of Patent: September 12, 2000Assignee: Ebara CorporationInventors: Kazunari Tanaka, Chiaki Igarashi, Yoshihiko Sadaoka
-
Patent number: 6087181Abstract: The present invention discloses a method for improving the speed and sensitivity of optical spectroscopic techniques for remote detection of trace chemical species in a carrier gas. The disclosed method can be applied to any optical spectroscopic detection technique whose sensitivity decreases as the total pressure of the sample decreases. The method employs an inert and non-absorbing buffer gas to supplement the pressure exerted by the carrier gas. This ensures that the total pressure of the sample, and hence sensitivity of the detection technique, remains high. The method is especially useful when measuring concentration of chemical species produced at small rates, and therefore should prove useful for rapid serial screening of combinatorial libraries of compounds.Type: GrantFiled: March 16, 1998Date of Patent: July 11, 2000Assignee: Symyx TechnologiesInventor: Pejun Cong
-
Patent number: 6063637Abstract: Sensors (20, 50, 70) for use in detecting the presence of sugars and other analytes (target molecules). The sensor is composed of a metal complex that binds to the target molecule and releases a proton or includes an exchangable ligand which is exchanged for the target molecule during the binding interaction between the metal complex and the target molecule. The result of the binding interaction is the release of a proton, hydroxide ion or ligand species generated during the ligand exchange. Measurement of the release of proton, hydroxide ion or other ligand species from the sensor (20, 50, 70) provides an indirect indication of target molecule concentration. The metal complexes may be attached to support structures (10, 12) to provide both anchoring and positioning of the metal ions to increase selectivity of sugar/metal complex interactions. Detection systems in which pH is used as an indication of proton or hydroxide release are disclosed, as are detection systems in which Cl.sup.- release is used.Type: GrantFiled: July 7, 1997Date of Patent: May 16, 2000Assignee: California Institute of TechnologyInventors: Frances H. Arnold, Zhibin Guan, Chao-Tsen Chen, Guohua Chen
-
Patent number: 6046054Abstract: The selectivity of response of resistive gas sensors to specific gases or vapors is improved by the selection of specified gas-sensitive materials which are not previously known for the applications described, which include detection of hydrocarbons in the presence of CO, H.sub.2 S, SO.sub.2, chlorine, NO.sub.2, CO.sub.2 (especially in low concentrations), CFC's, ammonia, free oxygen by determination of partial pressures, and numerous organic gases and vapors.Type: GrantFiled: December 9, 1997Date of Patent: April 4, 2000Assignee: Capteur Sensors & Analysers, Ltd.Inventors: Peter McGeehin, Patrick Timothy Moseley, David Edward Williams, Geoffrey Stephen Henshaw, Darryl Hirst Dawson, Laura Jane Gellman
-
Patent number: 5993742Abstract: A device for the investigation of liquids, in particular of waste water, includes at least one reaction chamber for receiving the liquid to be investigated as well as liquids for analysis from storage containers. The reaction chamber is disposed in a housing while the storage containers are accommodated within the housing or are set up outside. The housing may be positioned in a freely floating manner within the liquid to be investigated or may be set up outside.Type: GrantFiled: July 24, 1997Date of Patent: November 30, 1999Assignee: ABB Patent GmbHInventors: Dieter Binz, Albrecht Vogel, Brith Claesson, Hubert Braendle, Sean Keeping
-
Patent number: 5985674Abstract: In order to quickly and economically evaluate cleanliness of a metal with high representativity when quantities, compositions, etc., of non-metallic inclusion particles existing in a metal and resulting in product defects are evaluated by a sample collected during the production process of the metal, the present invention provides an evaluation method involving the steps of levitation-melting a metal piece for a predetermined time by cold crucible levitation-melting means, discharging non-metallic inclusion particles contained in the metal piece to the surface of a molten metal, and directly analyzing a curved and non-smooth sample surface after solidification by a fluorescent X-ray analysis method using an energy dispersion type spectroscope, or by other chemical or physical measurements, to measure or analyze the quantities of elements constituting the non-metallic inclusion particles and to determine quantity of the non-metallic inclusions.Type: GrantFiled: December 13, 1996Date of Patent: November 16, 1999Assignee: Nippon Steel CorporationInventors: Kazushige Umezawa, Tokio Suzuki, Koichi Chiba, Ryuji Uemori, Takehiko Toh, Hiroyuki Kondo, Katsuhiro Fuchigami, Eiichi Takeuchi, Masamitsu Wakoh, Akihiro Ono
-
Patent number: 5972296Abstract: Oxygen sensor for measuring resistance as a function of oxygen partial pressure, made of alkaline-earth-doped perovskitic lanthanum ferrites with the general formulaLa.sub.1-x Me.sub.x FeO.sub.3-.delta.where Me is one of alkaline earth metals, Mg, Ca, Sr, and Ba, x is a degree of doping of the lanthanum ferrites. The oxygen sensor oxygen deficit of anion is 6=0 to 0.25, and the degree of doping of the lanthanum ferrites is x=0.1 to 0.3 and is selected to provide a temperature independent resistance property to the oxygen sensor in a lean range.Type: GrantFiled: March 27, 1998Date of Patent: October 26, 1999Assignee: Heraeus Electro-Nite International, N.V.Inventors: Karl-Heinz Hardtl, Ulrich Schonauer, Andreas Krug
-
Patent number: 5965452Abstract: An improved biologic electrode array and methods for manufacturing and using the same. In one aspect, a matrix of electrodes each coupled to a respective sample-and-hold circuit is provided. The electrodes and sample-and-hold circuits are integral and form an array within a single semiconductor chip, such that each sample-and-hold circuit may be loaded with a predefined voltage provided by a single, timeshared digital-to-analog converter (DAC). Further, all of the sample-and-hold circuits may be accessed through a multiplexer which may be scanned through some or all of the electrode locations. Each sample-and-hold circuit may comprise a capacitor and one or more transistor switches, the switch(es), when closed, providing electrical communication between the capacitor and a source line formed in the matrix.Type: GrantFiled: July 9, 1996Date of Patent: October 12, 1999Assignee: Nanogen, Inc.Inventor: Gregory T. A. Kovacs
-
Patent number: 5958785Abstract: Chronic or long-term alcohol consumption is detected and diagnosed by determining the levels of an alcohol-specific ethanol glycoconjugate biomarker, identified as ethyl .beta.-glucuronide, in body fluids (e.g. urine) of subjects by calorimetric reaction using qualitative and quantitative assay methods. Ethyl glucuronide has been newly observed and detected as a direct indicator of chronic alcohol consumption, and can be isolated and purified. Economical and reproducible assay methods, such as a chromatographic spot assay, ascending or thin layer chromatography assay, and high pressure liquid chromatography assay provide reliable, objective, and sensitive methods for detecting and monitoring a chronic alcoholic condition. Both the presence of the alcohol-specific ethyl glucuronide and a substantial increase in its levels are diagnostic of chronic alcoholism.Type: GrantFiled: August 22, 1997Date of Patent: September 28, 1999Assignee: Research Foundation for Mental HygieneInventors: Raju K. Pullarkat, Premilia S. Pullarkat, Simhachalam Raguthu
-
Patent number: 5952237Abstract: The present invention provides a method by which harmful trace gases in a gaseous mixture containing as such harmful halogen gases, halogenated hydrogen gases, acid gases, oxidizing gases, basic gases, organic acid gases, especially halogen gases or halogenated hydrogen gases, are detected by using tetraphenylporphyrin (TPP) and quantitated from a calibration curve constructed therefrom, where the range of detectable concentration is made adjustable so that harmful gas can be detected and quantitated over a broad range of concentration. Furthermore, this invention also provides a method for extending the accessible range of gas concentration by adjusting the sensitivity of the detector material via control of tetraphenylporphyrin concentration in matrix polymer of the detector material, by controlling the gas concentration range via measurement at a specific wavelength(s), and by the use of a plurality of detector materials with pre-set assay sensitivity.Type: GrantFiled: October 9, 1996Date of Patent: September 14, 1999Assignee: Ebara CorporationInventors: Kazunari Tanaka, Chiaki Igarashi, Yoshihiko Sadaoka
-
Patent number: 5952235Abstract: The present invention relates to methods for detecting teratogen exposure in neonates. In particular, the present invention is directed to the detection of prenatal (i.e., in utero) exposure to ethanol. In accordance with the present invention, fatty acid ethyl esters, produced as the by-products of non-oxidative ethanol metabolism are detected in samples such as meconium and cord blood.Type: GrantFiled: April 14, 1997Date of Patent: September 14, 1999Assignee: Case Western Reserve UniversityInventor: Cynthia Bearer
-
Patent number: 5919710Abstract: A method for the quantitative determination of dissolved oxygen in a liquid fuel includes the steps of doping a sample of the fuel with a preselected concentration of a probe material including a luminophor which exhibits luminescence of wavelength which is quenched by oxygen dissolved in the fuel, illuminating the fuel with light from a coherent light source, such as a laser, of a wavelength which induces the luminescence in the luminophor, and thereafter measuring the change with time of the luminescence from the luminophor in the fuel and determing from the change with time of the luminescence the concentration of oxygen in the fuel.Type: GrantFiled: July 16, 1997Date of Patent: July 6, 1999Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: James R. Gord, Steven W. Buckner, William L. Weaver, Keith D. Grinstead, Jr.
-
Patent number: 5908789Abstract: The invention relates to a method and apparatus for determining the concentration of at least carbon dioxide in a gas mixture on the basis of the absorption of infrared radiation (2), said apparatus comprising: a radiation source (1), the radiation emitted thereby being aligned to travel through a measuring cell (4) containing a gas mixture (6) to be analyzed; an optical band-pass filter (10), which is transmissive to a first wavelength band and positioned on the path of radiation emerging from the measuring cell or entering into the measuring cell through which the radiation passes; and a first detector (14), positioned in the radiating direction downstream of said first band-pass filter and used for detecting the radiation intensity falling thereon. Said optical band-pass filter (10) has a band-pass which lies within the wavelength range of 4.38 .mu.m-4.47 .mu.m for measuring the total concentration of carbon dioxide by means of the absorption spectrum of a molecule .sup.13 CO.sub.Type: GrantFiled: March 12, 1997Date of Patent: June 1, 1999Assignee: Instrumentarium OyInventor: Kurt Peter Weckstrom
-
Patent number: 5877027Abstract: An analytical method for the quantitative determination of the impurities in silicon dioxide by which trace amounts of hardly soluble impurities contained in silicon dioxide can be reliably decomposed and converted into a solution so that the contents of all of the impurities contained in silicon dioxide or, in particular, zirconium in a natural quartz powder can be accurately determined. Silicon dioxide is decomposed with hydrofluoric acid or an acid mixture of hydrofluoric acid and another inorganic acid to give a decomposition solution which is, as such or after admixture with another inorganic acid, subjected to evaporation to dryness and the residue is heated to cause fusion with addition of a salt or hydroxide of an alkali metal followed by dissolution of the salt or hydroxide of an alkali metal with pure water or with an aqueous solution of an inorganic acid to give an aqueous solution which is subjected to quantitative analysis of the impurities therein.Type: GrantFiled: August 27, 1997Date of Patent: March 2, 1999Assignee: Shin-Etsu Quartz Products Co., Ltd.Inventors: Katsuhiko Kemmochi, Kiyotaka Maekawa, Chuzaemon Tsuji, Manabu Saitou, Hiroyuki Miyazawa, Hiroyuki Watanabe
-
Patent number: 5869344Abstract: The invention comprises a novel sample introduction system which incorporates a venturi pump to convey a sample gas to an analytical instrument at atmospheric pressure. An APCI, ICP or MIP mass spectrometer is preferred as the analytical instrument. Using such an inlet with an APCI mass spectrometer, the real-time analysis of trace materials present in breath is facilitated, enabling, for example, the release of compounds responsible for aroma and taste to be analysed during eating and drinking. The invention can also be used for headspace analysis and for monitoring the release of fragrances from skin or clothing.Type: GrantFiled: July 18, 1997Date of Patent: February 9, 1999Assignee: Micromass UK LimitedInventors: Robert Steven Timothy Linforth, Andrew John Taylor
-
Patent number: 5843784Abstract: To permit detection of trace unstable reaction products to clarify the reaction process of oxygenation, this invenion provides a method of introducing positron nuclide .sup.15 O as an oxygen additive into the reaction system.Type: GrantFiled: September 13, 1996Date of Patent: December 1, 1998Assignee: Research Development Corporation of JapanInventors: Yasuyoshi Watanabe, Bengt Langstrom
-
Patent number: 5834313Abstract: A sterilization system using a sterilization process monitoring device which is capable of indicating the efficacy of the sterilization process in an enclosed sterilization container while still maintaining the sealed state of the sterilization container. The process monitoring device comprises at least one biological indicator and/or at least one chemical indicator. Upon completion of the sterilization cycle, the process monitoring device can be advantageously removed from the system to determine chemical and/or biological efficacy of the sterilization process. The removal of the biological and/or chemical indicators does not disturb the sterilized state of the articles inside the sterilization container.Type: GrantFiled: September 19, 1997Date of Patent: November 10, 1998Assignee: Johnson & Johnson Medical, Inc.Inventor: Szu-Min Lin