Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.

Abstract: We report a method of a method for detecting an epileptic seizure, comprising providing a first body signal reference value; determining a current body signal value from a time series of body signals; comparing the current body signal value and the first reference value; determining a work level of the patient; determining whether the current body signal value comprises an ictal component, based on the work level and the comparing; issuing a detection of an epileptic seizure in response to the determination that the current body signal value comprises the ictal component; and taking at least one further action (e.g. warning, delivering a therapy, etc.), based on the detection. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

Abstract: The present invention relates to methods for measuring molecular interactions in a viscoelastic material, as well as related products and kits. The methods involve, for instance, taking multiple pressure measurements in the viscoelastic material and calculating the complex modulus from the pressure measurements to produce the measurement of viscoelastic properties in the viscoelastic material. Also included in the invention are methods and systems for detecting molecular interactions in vivo.

Abstract: A probe for detecting reflux in the oesophagus by detecting the level of turbidity at different points in the oesophagus. The probe consists of multiple pairs (32) of optical fibres with each pair being made up of a source optical fibre (2) and a detection optical fibre (3), a light source being attached to the source optical fibres and a light detector being attached to the detection optical fibres.

Abstract: A sample collection device for a fluid includes: a substantially disk-shaped body having a periphery; a capillary channel extending through the body and bounded by the periphery, having a first end and a second end, wherein the first end is adapted to draw the fluid into the channel by capillary action; a sample collection well located in the vicinity of the second end and in fluid communication with the capillary channel; and an axis of rotation extending through the center of the disk and which is substantially perpendicular to the major surface of the disk-shaped body. In a preferred embodiment, the sample collection device is adapted to rotate about the axis of rotation within a cartridge having a housing comprising an air vent in fluid communication with the capillary channel when the disk is rotated in a first position.

Abstract: One or more embodiments of techniques or systems for heath monitoring or monitoring one or more health parameters of a user are provided herein. Systems or components of a vehicle may monitor one or more vital or health parameters of an occupant of a vehicle, driver, passenger, etc. For example, a seat may have sensors embedded within that may measure characteristics or attributes associated with the occupant. In one example, a scale may be integrated with the seat to monitor a weight of an occupant on a day to day basis. As another example, a seatbelt or one or more portions of the seat may have heart rate monitors that check a heart rate of an occupant. Additionally, warnings or alerts may be provided when a signature is detected, such as an abnormal heart beat, etc. In this manner, health monitoring may be provided.

Abstract: Described are methods and systems to allow the use of a very simple physiological meter without a user input interface (i.e., buttonless) while maintaining the ability to store time linked measurement records for retrospective or prospective analysis of the measured physiological measurements with a bistable display to allow for a display of plural prior physiological measurements without necessitating the activation (e.g., turning on or manipulation of the user input interfaces) of the physiological meter.

Abstract: Methods and systems are provided for recharging a power module of a sensor (e.g., a wireless sensor). The system may include a charging station, which may receive and recharging the power module of the sensor. The charging station may be configured to recharge the power module directly or inductively. Furthermore, the charging station may be configured to recharge the power module while the power module is removed from the sensor or while the power module is operatively coupled to the sensor. Additionally, the charging station may be a component of a monitoring device, which may operate in combination with the sensor.

Abstract: The device and method of the invention generally relate to a system and method for percutaneous delivery, implantation and securement of an anchor at a target site. The system comprises an anchor having a bridge, a first stabilizer having a crimped state and a deployed state, a second stabilizer having a crimped state and a deployed state, and a positioning arm. The system may further comprise a cannula, pushrod, and sheath. The system permits the deposit of an anchor at a target location in the body by utilizing a controlled amount of force. The anchors and methods are particularly well-suited to implantation within the body of a living animal or human to monitor various physiological conditions.

Abstract: Some embodiments provide a system for synchronizing and configuring monitoring devices. In some embodiments, a patient monitoring device settings module is configured to automatically provide configuration settings to a plurality of patient monitoring devices. A monitoring device data module is configured to receive measurement data from at least one of the patient monitoring devices. An electronic medical records system interface is configured to provide patient data at least partially derived from the received measurement data to an electronic medical records system. A patient records interface is configured to provide patient data to at least one of the patient monitoring devices.

Abstract: A device and method for analyzing characteristics of a fluid. The device is a bolus arranged to remain within the fluid for the analysis. The bolus includes a sensor module, a fluid analysis module, a fluid pumping module and a control and data transmission module. The sensor module includes a transducer element to generate acoustic signals and convert acoustic signals. The information derived from generating and receiving acoustic signals is used to obtain information about constituents and conditions of the fluid. That information may be transferred to a near or remote location for analysis. The device and analysis method are suitable for evaluating the health of animals. The device may be used in a telemedicine environment at an animal health facility. It may also be uploaded to a database for use in the analysis of a group of sources of fluid, such as a herd of cows.

Abstract: The present invention is directed toward a wound dressing comprising a foam body made of polyurethane material treated with a plurality of colored biocidal dyes with at least one of the dyes being gram positive and at least one of the dyes being gram negative to dye the body a distinct color. The body has at least one planar surface and ranges from about 1 mm to about 10 mm in thickness and has an outer film cover and border with a hydrogel adhesive secured to the body. The foam body changes color when placed in contact with an infected wound site.

Abstract: Systems, devices, and methods are provided that enable the sensing of an analyte level within, e.g., the dermal layer of the skin of a subject. These systems, devices, and methods can utilize modalities that increase perfusion in an area local to a dermal sensor.

Abstract: The objective of the invention is to enhance measurement accuracy in a device for measuring a biological sample. To attain this objective, the invention is provided with a main case (2) having a sensor insertion section (1), a measurement section (7) connected to the sensor insertion section (1), a controller (8) connected to the measurement section (7), and a display (3) connected to the controller (8). An acceleration sensor (5) is furnished for detecting a shock applied to the sensor insertion section (1).

Abstract: Method and apparatus for optimizing analyte sensor calibration including receiving a current blood glucose measurement, retrieving a time information for an upcoming scheduled calibration event for calibrating an analyte sensor, determining temporal proximity between the current blood glucose measurement and the retrieved time information for the upcoming calibration event, initiating a calibration routine to calibrate the analyte sensor when the determined temporal proximity is within a predetermined time period, and overriding the upcoming scheduled calibration event using the current blood glucose measurement are provided.

Abstract: This invention relates to improvements to medical devices such as biosensors containing proteins such as oxidoreductases, for example oxidase and/or peroxidase enzymes. More generally it relates to novel compositions containing proteins which are stabilised to ionising radiation.

Abstract: The present disclosure provides a sensor port configured to receive a plurality of analyte sensors having different sizes, shapes and/or electrode configurations. Also provided are analyte meters, analyte monitoring devices and/or systems and drug delivery devices and/or systems utilizing the disclosed sensor ports.

Abstract: Several embodiments described herein are drawn to methods of identifying an analyte on a subject's skin, methods of generating a fingerprint, methods of determining a physiological change in a subject, methods of diagnosing health status of a subject, and assay systems for detecting an analyte and generating a fingerprint, by nanostructure-initiator mass spectrometry (NIMS).

Abstract: A health monitoring and diagnostic device (LIFESTREAM cholesterol meter) configured as a self-contained testing and diagnostic unit in a clam-shell type case. One side of the case includes a spring-loaded finger stick and a compartment for carrying one or more packages of disposable items including a test strip, a needle for the finger stick, and an alcohol swipe. The other half of the case includes a test strip reader, a key pad, and a liquid crystal display. The meter reads a test strip carrying a droplet of blood and receives additional diagnostic information from the patient, such as age, gender, weight, and family history of heart disease. Within minutes, the meter displays test results, including total cholesterol levels. The meter also displays additional diagnostic results, such as the patient's “cardiac age,” recommended weight loss, and a cardiac risk assessment. The meter also works in connection with a network-based comprehensive health analysis and reporting system.

Abstract: A hydration sensor or sensing element is configured to measure the hydration level of a user. The sensing element can include a water-permeable material positioned in between two water-impermeable material. The sensing element can be coupled to a bottle of fluid, or a carrier with a timer. The sensing element can be incorporated into a handheld device. The sensing element can be a disposable element, an element applicable for more than one-time use, or a re-usable element. The sensing element or sensor can be calibrated for a specific user or a group of users. One or more additional sensors that do not measure hydration level of the user can be coupled to a hydration sensing element to determine the amount of fluid consumption for the user in different conditions.

Abstract: Devices and methods for maintaining a medical device on-body are provided. Embodiments include medical device securement systems having first and second on-body securement elements. Also provided are systems and kits for use maintaining a medical device on-body.

Abstract: Embodiments of the present invention provide a device and method for treating animal skin to produce tautness in the skin during the insertion of an analyte sensor. A device in accordance with embodiments of the present invention includes a housing that partially encloses a cavity and is adapted for mounting onto animal skin and a sensor insertion module adapted to insert an analyte sensor through animal skin.

Abstract: A tape cassette for a medical handheld device is disclosed as comprising a carrier tape, which carries test fields for assaying a sample of a human or animal bodily fluid and/or lancets as functional elements, a supply chamber, in which a supply section of the carrier tape comprising unused functional elements is positioned, a winding unit, in order to wind up the carrier tape and draw it through a tape exit opening of the chamber, so that the functional elements may be brought sequentially into a usage position. The carrier tape in the tape exit opening is oriented transversely to the supply section positioned in the supply chamber.

Abstract: A patient monitoring/defibrillation instrument displays patient vital signs in numeric form or as graphical waveform traces. Under normal room lighting conditions the numeric and waveform information is displayed in color against a black or gray background. When the patient monitor is operated outside or in bright light, the user has the option to select a color map for display of the patient vital signs information in a highly contrasting manner such as black numeric or waveform information against a bright background such as yellow. The high contrast display, while being objectionable in most indoor settings, has been found to comfortably and effectively display the monitored information in sunlight without the need to increase power to the display.

Abstract: An implantable medical device system and associated method receive a signal from an implantable sensor operatively positioned relative to a vein, the signal being responsive to changes in a diameter of the vein. A diameter of the vein is determined in response to the sensor signal and used in estimating central venous pressure (CVP).

Abstract: This assembly includes: a transportable support; a strip attached to the support and including an application area for applying the sample and at least one reagent required for the analysis; a piercing member for piercing the skin and a blood vessel; and a container for collecting, storing and returning the sample of human or animal blood. The piercing member is inserted into the container. The tip is connected to the support. The container is connected to the support in a removable manner between a storage configuration and a use configuration, in which the container is placed close to the application area.

Abstract: A system and method are disclosed for detecting a vasoactive agent in patient's bloodstream. In one embodiment, an input signal is received that is associated with arterial blood pressure. A change of an arterial blood pressure parameter over time is determined. A vasoactive agent is then automatically detected using the determined change. In another embodiment, a waveform associated with an arterial blood pressure signal can be received. A parameter associated with the received waveform is calculate. Then the calculated parameter can be used to determine the presence of a vasoactive agent. In yet another embodiment, detection of a vasoactive agent in any of the other embodiments can be used in a calculation of a hemodynamic parameter, such as cardiac output, stroke volume, systemic vascular resistance, stroke volume variation, cardiac index, stroke volume index, systemic vascular resistance index, vascular compliance, and vascular tone.

Abstract: Embodiments of the present invention provide a blood analyte sensing system (10) that includes an integral calibrant concentration measurement system. The blood analyte sensing system includes a blood sensor (22), a calibration system and the calibrant concentration measurement system. The calibrant concentration measurement system is connected in communication with both the calibration system and the blood sensor. The calibration concentration measurement system includes a calibrant sensor (20) configured to measure a calibrant concentration in response to exposure to the calibrant. The calibration concentration measurement system is also configured to determine the analyte concentration of the patient's blood using the calibrant concentration, calibration signal and the blood signal.

Abstract: An implantable, miniaturized platform and a method for fabricating the platform is provided, where the e platform includes a top cover plate and a bottom substrate, top cover plate including an epitaxial, Si-encased substrate and is configured to include monolithically grown devices and device contact pads, the Si-encased substrate cover plate including a gold perimeter fence deposited on its Si covered outer rim and wherein the bottom substrate is constructed of Si and includes a plurality of partial-Si-vias (PSVs), electronic integrated circuits, device pads, pad interconnects and a gold perimeter fence, wherein the device pads are aligned with a respective device contact pad on the top cover plate and includes gold bumps having a predetermined height, the top cover plate and the bottom substrate being flip-chip bonded to provide a perimeter seal and to ensure electrical connectivity between the plurality of internal devices and at least one external component.

Abstract: A hydration monitoring apparatus is disclosed. The hydration monitoring apparatus comprises at least one sensor and an analysis unit. The hydration monitoring apparatus may take at least one biometric, biological, and/or physiological measurement of an individual and measures the hydration level, dehydration level or status, or bodily fluid level of an individual. The hydration monitoring apparatus indicates the hydration level, dehydration level or status, or bodily fluid level of an individual based on one or more biometric, biological, and/or physiological measurements. In one embodiment of the invention, the hydration monitoring apparatus determines whether to inform the user of their hydration level, dehydration level or status, or bodily fluid level. In one embodiment the hydration monitoring apparatus further comprises an informing device that informs the individual that the individual is approaching dehydration.

Abstract: Provided is a container for testing blood (1A) including: a main container body (2) having an internal space (3) that stores an initial blood flow; a blood inflow port (5) that allows the initial blood flow to inflow; a blood outflow port (6) that allows the stored initial blood flow to outflow; a blood drawing part (21) that is connected to the blood outflow port (6) and allows the initial blood flow to be drawn; and a first discharge part (7) that has a hydrophilic bacteria-impermeable first filter (12) and discharges air in the internal space, wherein the first discharge part (7) and the blood outflow port (6) are disposed at an end part of the main container body (2) on the same side, and the blood drawing part (21) connected to the blood outflow port (6) includes: a holder (22) whose one end is provided with the needle assembly (23) and whose other end has an opening (22c) in which a testing instrument storing the initial blood flow is inserted.

Abstract: Cerebral blood volume changes are measured to evaluate, from properties of low-frequency components of such changes and heart rate changes calculated by analysis, a distribution of cerebral blood vessel hardness and its change over time to thereby estimate and display diseased and dangerous portions based on the evaluation. This is attainable by a biological measurement system having a cerebral blood volume measurement unit which measures a regional cerebral blood volume of a body under test, an analyzer unit that analyzes a signal measured by the cerebral blood volume measurement unit, an extraction unit for extracting, based on an output of the analysis unit, information concerning a regional cerebral blood vessel state of the test body, and a display unit which displays a measurement result of the cerebral blood volume measurement unit, an analysis result of the analyzer unit or an extraction result of the extraction unit.

Abstract: The present application relates to a molecular exchange device (1) for use with an analysis and control apparatus and a method of manufacturing a molecular exchange device.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: A wearable medical device (10) comprising: spectacles or eyeglasses (12) including at least one temple piece (14) and nose-engagers (16); at least one bio-sensor (18) for measuring at least one physical parameter of a person wearing said spectacles (12), said bio-sensor (18) being associated with one of said temple piece (14) or said nose-engagers (16); information storage (20) incorporated with said spectacles (12) for storing information received from said bio-sensor (18); a transmitter (22) for transmitting said stored information; and a power supply (24) for driving said bio-sensor, said storage and said transmitter.

Abstract: A measurement system may comprise a sensor wire and a transceiver unit. The sensor wire may comprise an insertable portion configured to be inserted in a blood vessel of a patient's body and a sensor disposed within the insertable portion at a distal end of the senior wire. The sensor is configured to measure a parameter when inserted inside the patient. The transceiver unit may comprise: a housing adapted to be connected to a proximal end of the sensor wire; and a first communication module within the housing adapted to wirelessly communicate by a communication signal with an external second communication module in order to transfer information to the external second communication module.

Abstract: Patient mobile computing system (1) and method for predicting exacerbations in a patient illness related status, the method includes collecting patient sensor data using sensors (8), and executing a local prediction model. The local prediction model includes a Bayesian network (6) to obtain a probability of an exacerbation of a patient status. The Bayesian network (6) receives patient input data, patient sensor data, and providing probability data, and the local prediction model provides guidance data based on the probability data. The local prediction model (6) is implemented both in a portable device (1), such as a smart phone, and in a centralized patient data processing system (20).

Abstract: Methods and systems for providing data communication in medical systems are disclosed.

Abstract: A degradation data generator is used with a scaffold for delivery within a patient. The degradation data generator includes a driving circuit electrically coupled to drive an impedance of the scaffold. A detection circuit generates degradation data based on the impedance of the scaffold or other properties such as RF or lightwave transmission, conductance or absorption. The degradation data indicates an amount of biodegradation of the scaffold. A wireless transmitter is coupled to transmit the degradation data to a wireless degradation data receiver, while the scaffold is within the patient.

Abstract: The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of the invention, active attraction of biological markers are provided. A partial or complete analytic/detection assembly may also be integrated with the probe.

Abstract: The current invention discloses a treatment device having a heat source, a power source, a heat applicator and a lighting mechanism. The power source includes at least one battery having superior properties such as prolonged electricity production and prompt recharging. The heat applicator includes a heat conductive layer made from nanofibers, providing highly efficient heat distribution to the targeted regions. The lighting mechanism employs light emitting nano fibers to treat targeted regions. The power source provides energy to the light source, which generates light so that the applicator may distribute to an injury site or wound bed of a user. The heat source may be an exothermic chemical reaction designed to last for several hours supplying heat to the treatment device or an electronically produced heat. The treatment device further comprises a plurality of electrodes for electrical stimulation treatment.

Abstract: An analyte monitoring system, which can be used to monitor blood sugar, is provided with a sensor which detects a plurality of blood sugar levels in blood on the basis of a sampling interval, a meal data setting unit which sets information based on meal contents, and a sampling interval setting unit which sets the sampling interval of the sensor using the information based on meal contents set by the meal data setting unit. By predicting a fluctuation curve of the blood sugar level after a meal by information based on meal contents to thereby change the sampling interval, a fluctuation state of the blood sugar level can be efficiently monitored.

Abstract: A seamless, substantially continuous, independent and wearable health monitoring and self-alert system, configured for use by a living being on a daily basis, including by a healthy living being. The wearable health monitoring and self-alert system includes a garment worn by the living being adjacently to preconfigured portions of the body of the living being. The system further includes a garment-control device that includes a garment-processor and a battery. The system further includes a multi-lead ECG measuring device including multiple electrodes or probe-devices embedded into the garment, and an alerting unit. Preferably, the system further includes multiple sensing devices selected from the group consisting of sensors and electrodes. At least one of the sensing devices is embedded into the garment, wherein each of the sensing devices is configured to detect a predetermined physiological or chemical parameter of the living being.

Abstract: A system for measuring and converting to an observer intelligible form an internal physiological parameter of a patient. The invention allows transcutaneous telemetry of intracranial pressure via a system which includes a patient implanted sensor module and an external processing module, optically coupled to the sensor module via an external coupling module. A sensor within the sensor module transduces the measured pressure and a near infrared emitter transmits the telemetry when interrogated by the external coupling module. A set of tuned inductor-crystal circuits comprised in part of a cylindrical crystal oscillator whose resonant frequency is sensed by a dipper circuit arrangement is provided. Power for the sensor module is derived inductively through rectification of a transcutaneously-applied high-frequency alternating electromagnetic field generated within the external coupling module.

Abstract: A protective container for holding a reusable control part of a transcutaneous sensor system for detecting at least one analyte in a bodily fluid is disclosed. The control part includes at least one coupling, which has at least one sensor coupling for connection to at least one transcutaneous sensor. The protective container has at least one container housing. The control part can be held in the container housing. The container housing is adapted to shield the control part from environmental influences. The container housing also has at least one connector which can be connected to the coupling and seals the latter in a media-tight fashion.

Abstract: The invention provides, inter alia, automated medical methods and apparatus that test PD effluent in a flow path (e.g., with an APD system or CAPD setup) to detect, for example, the onset of peritonitis, based on optical characteristics of the effluent resolved at cellular scales of distance. For example, according to one aspect of the invention, an APD machine includes, in an effluent flow path, apparatus for early stage peritonitis detection comprising an illumination source and a detector. The source is arranged to illuminate peritoneal effluent in a chamber that forms part of the flow path, and the detector is arranged to detect illuminant scattered by the effluent. The detector detects that reflected or scattered illuminant at a cellular scale of resolution, e.g., on a scale such that separate cellular-sized biological (or other) components in the effluent can be distinguished from one another based on scattering events detected by the detector.

Abstract: An implantable sensing system that includes a sensor for sensing a biological parameter, a processor connected to the sensor for processing the parameter and a drug delivery unit connected to the processor for responding to the processor based on the parameter. The processor is programmed to adjust an output of the sensor by compiling an array of data relating to the sensor, adjusting a sensor parameter a first time based on data in the array, adjusting a curve representing the sensor output based on data in the array and adjusting the sensor parameter a second time based on data in the array.

Abstract: Apparatus, systems and methods employing contact lenses having one or more sensor that sense an analyte in tear fluid and one or more recesses that collect the tear fluid. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a recess formed within the substrate configured to collect tear fluid when the contact lens is worn. The contact lens further includes at least one sensor disposed within the substrate configured to sense presence of an analyte in the collected tear fluid.

Abstract: In one embodiment, a miniaturized wearable nuclear magnetic resonance (NMR) apparatus is described. The example NMR apparatus accesses data (e.g., table, mathematical expression) that describes a relation between a nuclear magnetic resonance (NMR) signal decay rate and a known concentration of glucose in a fluid. The NMR apparatus acquires, non-invasively and in-vivo, an observed NMR signal decay rate from a fluid in a patient, and estimates a concentration of glucose in the fluid in the patient by comparing the observed NMR signal decay rate with the data that describes the relation between the NMR signal decay rate and the known concentration of glucose. The data may be generic to a population and a class of devices or may be customized to an individual patient and an individual device.

Abstract: An orthopedic system to monitor a parameter related to the muscular-skeletal system is disclosed. The orthopedic system includes electronic circuitry, a sensor, and a remote system to monitor and measure. The sensor is configured to measure color or turbidity. The electronic circuitry is coupled to and interfaces with the sensor. The electronic circuit includes a transmitter to transmit measurement data from the sensor to the remote system. The orthopedic system is configured to monitor color or turbidity of a fluid in proximity to the muscular-skeletal system. The orthopedic system can transmit a signal when a predetermined color is detected or when the turbidity of the fluid exceeds a predetermined value. Alternatively, the remote system includes a processor and software configured to analyze the measurement data from the sensor and transmit a signal when a predetermined color is detected or when the turbidity of the fluid exceeds a predetermined value.