Abstract: An embodiment provides a permanent sealing assembly for a container, such as a reagent bottle. The permanent sealing assembly allows for drip-less reagent container exchange for liquid analysis instruments. The permanent sealing assembly may be integrated into a container, such as a reagent bottle, and provides an outflow tube that extends into the container. The permanent sealing assembly and the outflow tube thereof remain in the container such that, on an exchange of regent containers, a removable cap assembly of the liquid analysis instrument may be affixed to a new container of reagent without the risk of reagent from the old container contacting the surroundings. Other aspects are described and claimed.

Abstract: A sterile dispense system provides for transfer of a fluid from a disposable fluid-path to a vial without needles piercing the vial stopper, for disconnecting the vial from the disposable fluid-path while keeping integrity of the solution filled into the vial and to enable withdrawing of the solution from the vial. The pressure valve and luer valve are provided in serial connection to a fluid vial to enable clean filling and dispensing from the vial.

Abstract: A method identifies atypical antibodies in blood or blood product manufacturing processes that may produce false positives in quality control testing on intermediate or final products.

Abstract: A three dimensional printing device has a sterilizable printer assembly including at least one printing head, a printing platform, and a driving mechanism adapted to perform a movement of the at least one printing head relative to the printing platform along three degrees of freedom; a printer housing enclosing the printer assembly in a sterile manner, at least one aseptic connector fluidly connected to a corresponding one of the at least one printing head.

Abstract: A dispenser apparatus is disclosed herein. A dispenser is disclosed herein. In various aspects, the dispenser includes a piston slidably sealingly engagable with a container containing a unit dose of liquid therein. The dispenser includes a cutting edge disposed about a piston face of the piston, the cutting edge configured to open a covering of rigid construction sealingly engaged with the container, in various aspects. A passage is formed between a piston face of the piston and a nozzle outlet of a nozzle to communicate fluid from the container through the nozzle outlet by sliding of the piston within the container, in various aspects. Methods of use of the dispenser are disclosed herein. This Abstract is presented to meet requirements of 37 C.F.R. §1.72(b) only. This Abstract is not intended to identify key elements of the apparatus and methods disclosed herein or to delineate the scope thereof.

Abstract: A hemodialysis patient data acquisition and management system resides on a host computer which receives information from one or more non-invasive, optical blood monitors associated with a hemodialysis system. When a patient is undergoing hemodialysis treatment, a sensor assembly monitors the patient's blood flowing through the hemodialysis system and a controller for the blood monitor generates data which includes at least an identification code for the patient undergoing the treatment on the respective system, and non-invasively determined blood data taken at the onset of the scheduled treatment, such as initial Hgb, HCT, and SAT values. A host computer communicates with the one or more optical blood monitors, preferably via a wireless network, and the patient's session commencement data is downloaded to the host computer.

Abstract: A closed fluid transfer system for fluidly interconnecting a syringe to any one of a patient I.V. set, a vial and an I.V. bag, is provided and includes a housing defining an open distal end and an open proximal end, a base supported in the open proximal end of the housing and including a syringe adapter luer connector, a collar slidably and rotatably supported in the housing, the collar defining a longitudinal opening therethrough, a shuttle slidably extending through longitudinal opening of the collar, the shuttle defining a shuttle lumen extending longitudinally therethrough, a barrel supported on and extending over a distal end of the shuttle, a biasing member interposed between the collar and the shuttle for urging the collar away from the shuttle, and a seal interposed between the shuttle and the barrel, wherein the seal extends across the shuttle lumen and the central opening of the barrel.

Abstract: A reconstitution assembly includes a housing including a lower sleeve and an upper sleeve, including a first container and a second container disposed vertically opposite the first container. A transfer set assembly is disposed within the housing between the first container and the second container. The transfer set assembly includes an upper spike housing and a lower spike housing, with a flow path defined through the upper spike housing and the lower spike housing. The transfer set assembly is configured to access contents of the first container and then upon the activation of a triggering mechanism, create a fluid pathway between the first container and the second container. The triggering mechanism ensures the transfer set assembly sequentially accesses the contents of the first container before accessing the contents of the second container. The disposition of the first container activates the triggering mechanism.

Abstract: A vial adapter for a needle-free injection syringe and methods of filling a needle-free syringe from a vial of injectable fluid. One vial adapter embodiment includes a housing and a compliant valve. The housing includes a central divider located between a vial opening and a needle-free syringe opening. The housing also includes a hollow center post extending from the central divider toward the needle-free syringe opening and a hollow filling needle extending from the central divider toward the vial opening. Together, the filling needle and center post provide for fluid communication between the vial opening and the needle-free syringe opening. The compliant valve includes a surface forming a fluid tight seal with the central divider and an inner passageway. In addition, a syringe sealing surface provides for a fluid tight seal with a needle-free syringe placed into contact with the compliant valve.

Abstract: A port assembly for enabling contents of a first container to be mixed with contents of a second container. The port assembly has a port housing that is configured to receive a first container. The port assembly further includes an actuator axially fixed within a cavity of the port housing. The actuator is configured to open a first container by forcing a stopper sealing an opening of a first container into a cavity of a first container during activation.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial includes a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial includes a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a housing and a bag. In some embodiments, an initial volume of a regulating fluid can be contained within the bag. In some embodiments, the regulating fluid flows into the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands, and in other embodiments, the bag contracts.

Abstract: A process for lyophilizing a solution of an active agent in a container is provided. Solution of active agent is deposited into a container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization can be conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device (e.g., a syringe), containing an active agent in the form of lyophilized cake, and an array of such administration devices.

Abstract: A withdrawal spike unit (200) comprises a withdrawal spike component (30?) and an integrally formed adapter component (60?) that is adapted to couple with a vial (10) in a safe and secure manner. The integral formation of the component parts (30?, 60?) makes fully automated manufacture and assembly of assemblies comprising such a withdrawal spike unit (200) coupled to a vial (10) possible. As such, human errors associated with the assembly at the point of use are mitigated.

Abstract: Containers and components thereof for use in the medical industry and methods to manufacture the same are described. An example tab for use with a medical container includes opposing sheets sealed to define an open ended chamber into which a port is to be at least partially positioned. The port is to enable access to the medical container. The tab includes a tear seal defined by each of the opposing sheets and a first guide positioned on a first side of each of the tear seals. The tab includes a second guide positioned on a second side of each of the tear seals, wherein the first and second guides are to enable a tear to propagate substantially between the guides and adjacent the tear seals.

Abstract: A coupling component is disclosed for transmitting medical substances, comprising two channels for conveyance of medical substances in two substantially opposite directions and a means for releasable connection to a second coupling component having a further channel for creating a coupling. The connecting means is a thread. A method for conveying medical substances to and from a container is also disclosed.

Abstract: A blood or blood component collection and processing system, apparatus and method are disclosed. One embodiment includes a vascular access device and a blood collection container having a blood inlet and first and second blood component outlets. The outlets are located at opposite ends of the container, and a blood flow conduit extends between the vascular access device and collection container. The collection container is free of attachment to other blood collection containers when in an initial collection configuration at the time of collection.

Abstract: A method for providing a saccharide based lubricating or protective coating or layer on a substrate surface is provided. In particular, a lubricity and/or protective coating or layer made by said method is provided. Pharmaceutical packages or other vessels coated by said method and the use of such pharmaceutical packages or other vessels protecting a compound or composition contained or received in said vessel with a protective coating against mechanical and/or chemical effects of the surface of the vessel without a protective coating material are also provided.

Abstract: A needle-less vial assembly that includes an assembly body arranged at least partially within a neck of a vial, the body having a first portion within the vial for receiving a substance, a second portion that includes a means for matingly engaging with a syringe, and a channel defined therein, thereby enabling fluid communication of the substance between the vial and the syringe. The assembly further including a first inlet arranged longitudinally along a length of the first portion and proximate to the second portion, wherein the first inlet enables fluid communication between an interior of the vial and the channel, thereby enabling withdrawal of substantially all of the substance within the vial, and an outlet arranged at an end of the second portion of the body, thereby enabling a needle-less transfer of substances between the channel and the syringe.

Abstract: The present invention is directed to a container suitable for use in the disinfection of blood glucose meters and other medical devices. In one embodiment, the container comprises a tray with a formed cavity in it, such that a blood glucose meter or medical device may be placed and retained in it. In certain related embodiments, the meter has been wrapped in a disinfection wipe prior to placement into the container.

Abstract: A liquid collection bag is used as a part of an extracorporeal circuit and is connected via a tube to a storage container containing a priming solution. The collection container collects the priming solution from the storage container by a pressure differential between the pressure inside the collection container and the pressure inside the storage container. The liquid collection container is a flexible bag body having a partition part dividing the inside of the bag body into a first space and a second space. In addition, a communication part communicates the first space with the second space.

Abstract: Delivering a blood processing solution to blood in a blood bag includes coupling a first tube to a vented spike at one end and to a Y-shaped tube connector at a second end. An in-line microbiotic barrier filter is coupled to the first tube between its ends. A second tube is coupled to a transfer bag at one end and to the Y-shaped tube connector at its other end. A third tube is coupled to the output of the Y-shaped tube connector and sealed at its distal end. The blood bag includes a fourth tube that is sealed at a distal end. The third tube is welded to the fourth tube using a sterile tubing welder, wherein a functionally-closed, sterile flow path through which the blood processing solution can flow into the blood bag is maintained.

Abstract: A dispensing cartridge, particularly for dental impression materials, formed from a plastic material having at least one inlet and at least one outlet, and including a metal reinforcement tube.

Abstract: A cylindrical stopper for closing a medical system and a method for closing a medical system, and to the medical system itself, closed with the stopper of the invention.

Abstract: The present invention concerns fixed dosing of HER antibodies, such as Pertuzumab.

Abstract: A jacket retains a cylindrical drug vial and includes a substantially planar base having a length and a width, the length being greater than the width. A throughhole is sized to receive at least the lid of the vial therethrough. Two ramped devices project from a bottom surface of the base and are substantially aligned along the length of the base. The ramped devices are disposed on opposite sides of the throughhole.

Abstract: An apparatus (10) includes a body (2), a plunger (5), and an occlusion (4). The body is able to hold one or more medical substances therein. The body defines a longitudinal axis extending therethrough. The plunger is positioned within a portion of the body and is able to axially advance along the longitudinal axis. The plunger also defines an opening extending therethrough. The occlusion is able to extend through at least a portion of the opening of the plunger so that the plunger and the occlusion fluidly divide the body. The plunger is able to exert a first outward force against the body. The plunger is able to exert a second outward force against the body when the occlusion has been removed where the second outward force is less than the first outward force.

Abstract: A connector is configured to be connected to a syringe assembly provided with at least one syringe having an outer cylinder with a protruding tube-shaped port, and a holder which holds the syringe. The connector includes a connector main body mountable on a container containing a medical solution; a tube-shaped fitting section protruding from the upper section of the connector main body for receiving the syringe to connect the inside of the syringe and the inside of the container when the syringe port is fitted in the fitting section; and fixing means having a lock mechanism that fixes the syringe assembly to the connector main body when the syringe port is fitted in the fitting section, an operating section to release the fixed state provided by the lock mechanism, and a push-out section that pushes out the syringe assembly when the fixing releasing operation is performed.

Abstract: The method described herein reduces the amount of aggregating metal released into solutions of Interferon-beta.

Abstract: 5-cholesten, 3?, 25-diol, disulfate (25HCDS) has been found to be an authentic PPAR? agonist and LXR antagonist, and is used for the therapy of lipid disorders and inflammatory diseases, including without limitation fatty liver, inflammatory bowel, and atherosclerotic diseases.

Abstract: Products, processes, compositions, kits, and methods are provided for cartilage-derived implants. The implants can exhibit resistance to enzyme (e.g., collagenase, protease, etc.) digestion compared to the source tissue from which they were derived while still having one or more mechanical properties comparable to the source tissue from which they were derived. The implants can also have a plurality of molecular bridges between molecules of the cartilaginous material. The molecular bridges can connect one or more collagen fibrils and/or/with one or more glycosaminoglycans. The implants can also be treated with cationic detergent, packaged and sterilized with or without additional components, and surgically implanted into subjects.

Abstract: A drip chamber having an upper reservoir that is separated from a lower reservoir via a filter assembly, wherein a distance between the filter assembly and a bottom surface of the drip chamber is selected to prevent dislodged air bubbles of the filter assembly from being drawn into an intravenous fluid line that is coupled to the bottom surface of the drip chamber, during an infusion procedure.

Abstract: A container for storing donated blood plasma has a neck and an attachable locking cap. The cap may be rotatably attached to the neck. The cap and the neck are configured to lock the cap in at least one, and preferably two, rotational positions. In one position, tubes connected to the container are accessible. After the plasma has been collected and the tubes have been cut off and sealed, in the other position, the tube stubs are protected by the cap. The bottle and the cap may define structures that facilitate storing and protecting tubing wrapped longitudinally around the container, until the container is used to collect and store plasma.

Abstract: A surgical sponge and fluid monitoring system and method are provided. The system (100) includes a support ring (104) for securely supporting a container (101) with at least one port opening (206) for placing sponges (204) into the container through the at least one port opening. The support ring includes RFID communication circuitries (305, 307) that interrogate an RFID device (205) in the sponge (204) and an RFID device in the container. The support ring is mechanically linked to a load cell (706, 1329) in the system. The processor (1302) reliably detects when a sponge is placed into the container through the at least one port opening, identifies the type of sponge placed into the container, counts the number of sponges in the container, sorts the types of sponges, and calculates fluid loss for a patient in a surgical procedure. A user interface (1308, 114) keeps the medical professionals informed.

Abstract: A filling aid. The filling aid includes a needle housing portion including at least one tab having a starting position and a filling position, and a filling needle cradle including a filling needle, the filling needle cradle slidable connected to the needle housing portion and having a starting position and a filling position, wherein when the at least one tab on the needle housing moves from a starting position to a filling position, the filling needle cradle slides from a starting position to a filling position, and wherein when the at least one tab on the needle housing moves from a filling position to a starting position, the filling needle cradle slides from a filling position to a starting position.

Abstract: A flow control clamp having a first member and a second member movable from a first open position to a second irreversibly closed position wherein flow through a tube associated with the clamp is irreversibly prevented and cannot be restored. Systems and methods using such clamps are also disclosed.

Abstract: An access port for the introduction of a needle cannula tip into an IV tube set includes a rigid tubular housing and a resilient member disposed adjacent an inlet of the housing. The resilient member includes an axial perforation extending through the resilient member, and is normally closed by a resilient character of the resilient member. A depression is defined in a proximal face of the resilient member, and includes sidewalls extending between the proximal face and the axial perforation to guide the needle cannula tip toward the axial perforation as a needle cannula associated with the needle cannula tip is introduced into the access port.

Abstract: The disclosure relates to tube with a tube head (4) and a container (5) made of resilient material, wherein the tube head (4) is connected to the container (5), wherein the tube head (4) comprises a female Luer lock fitting (7) with a flow passage (17), the female Luer lock fitting (7) being designed for sealingly receiving a male Luer lock fitting (9) of a syringe (2), wherein a tamper-evident closure (11, 12, 13, 14) is arranged at the inner surface of the female Luer lock fitting (7) such that it closes the flow passage (17) in a closed state of the tube (1).

Abstract: A fluid transfer assembly comprise a first open end for connection to a syringe and a second open end for receiving a vial having a closure element. The second open end is adapted to engage and open the closure element and permit fluid in the vial to be transferred to the syringe from the vial, for example by gravity acting on the fluid in the vial.

Abstract: The present invention concerns a male connection part for connection with a female piercing member protection device having a longitudinal cylinder-like body having a longitudinal axis C, a first side and a second side, an outer and an inner surface, a barrier member arranged at the center of the first side of the male connection member, intersecting the longitudinal axis C, and a fluid communication channel extending from the barrier member of the male connection part to the second side of the male connection part, wherein the male connection part further comprises at least one turning grip protrusion to provide for an increased turning friction between the female piercing member protection device after assembly.

Abstract: Apparatus and methods are disclosed for use during surgical procedures for collecting autologous bone. A preferred bone collection assembly collects bone by compressing blood products away from trapped bone using a press. Such bone collecting assembly is easy and uncomplicated to use, and can be easily integrated into an operation where the need for collection and utilization of autologous bone exists.

Abstract: A transfer system suitable for medicaments comprising a vial socket, a housing having first and second open ends with the first open end being releasably connected to the vial socket, a needle hub mounted within the housing, a needle having first and second piercing ends mounted in the needle hub, a vial having a neck and a body, the vial being inserted in the vial socket and being non removably retained therein, a cartridge having a plunger sealing an open end thereof and a septum located at an opposite end of the cartridge, and an activation cap for causing the needle to penetrate a septum of the vial and the septum of the cartridge to permit transfer of components therebetween.

Abstract: A system for mixing the contents of a first container and a second container. The system includes the first container that has container body with an opening fluidly connected to a cavity defined by the container body, a first substance contained in the cavity, and a stopper sealing the opening. The second container includes a port assembly including a port housing connected to the second container and a retainer constructed to connect to the first container. The retainer is configured to rotate and move axially relative to the port housing, wherein relative rotation between the port housing and the retainer causes the retainer to move axially relative to the port housing. The port assembly further includes an axially fixed actuator constructed to force the stopper into the first container when the retainer is rotated relative to the port housing.

Abstract: A device (1) for the containment of platelet concentrates includes at least a bag (2) defining at least a containment chamber (3) having at least a mouth (4) for the entry of a platelet concentrate and at least a connection element for connection to an infusion line associated with the bag in correspondence to the mouth; the connection element includes a first and a second portion (5a, 5b) integrally associated together and includes at least a constantly open duct (6), passing through the first and the second portion and communicating with the chamber, where the first portion is associable with the infusion line and the second portion is associated with the bag in correspondence to the mouth, the first portion being separable from the second portion in such a way to interrupt the duct and define an opening (8) accessible from outside and including closing element (9) of the opening.

Abstract: A portable microbubble and drug mixing device is provided. The portable microbubble and drug mixing device comprises a flexible outer container comprising an interior chamber for accommodating a drug, and a rigid inner container within the flexible outer container and comprising an interior chamber for accommodating microbubbles. The outer container has a tensile strength at break less than or equal to approximately 15 MPa, and the inner container has a tensile strength at break greater than or equal to approximately 20 MPa and is capable of storing microbubbles at a concentration higher than or equal to approximately 5×106 microbubbles/ml. The inner container is configured to separate the microbubbles in the interior chamber of the inner container from the drug in the interior chamber of the outer container until a point of mixing when the microbubbles are released into the interior chamber of the outer container.

Abstract: A collecting device for fluids for medical use may include a rigid container internally defining a first chamber having a fixed volume, an auxiliary container having a deformable portion defining internally thereof a second chamber having a variable volume as a function of a deformable portion thereof, a passage able to set the first and the second chamber in fluid communication, an inlet port connected to at least one of the containers, and an outlet port connected to at least one of the containers, as well as a bypass line for bypassing the device.

Abstract: A connection device includes a main holder including a syringe holder to be attached to a syringe and a cannula holder which includes a double-head cannula. The cannula holder is located at a retracted position retracted with respect to the syringe holder in the pre-use state, and is advanced to an advanced position abutting on the syringe holder in the use state. The connection device further includes a separation preventing mechanism which engages the syringe to prevent separation of the syringe from the syringe holder in the state where the cannula holder is located at the retracted position. When the cannula holder is located at the advanced position, the separation preventing mechanism releases an engagement state with the syringe to permit the separation of the syringe from the syringe holder.

Abstract: This patent application teaches methods and apparatus of an efficient disposal chain system which includes a process of receiving fluid enclosing containers, transforming said containers into collection containers by integrating said containers into vacuum canister collection systems. Such a collection system includes a remote vacuum source configured to draw a vacuum force away from said container and towards said container. Such a vacuum source is configured to draw room air. Such a force is configured to draw waste materials along a path towards said collection container. A transformation of said containers includes deriving said containers from supply chains and transforming said containers into said collection systems at least in part by supporting said containers inside said canisters from below utilizing various configurations of measurement stands, said stands configured to support and accommodate various sizes, types and shapes of said containers.

Abstract: The present invention is directed towards a method and apparatus for packaging or containing, handling and managing of a variety of materials or other contents from a variety of sources which encounter use under various dynamic applications, conditions and for a plurality of purposes. The invention more specifically is directed towards one or more containers or packages, suitably fitted or used for the handling or managing of materials or other contents along one or more cycles or chains of use.